Research activity information

• 初診時から舌リンパ節に転移を認めた口底癌の1例
  武田 叡司; 格口 渉; 高橋 賢多; 栗林 和代; 松田 彩; 間石 奈湖; 樋田 京子; 足利 雄一; 大廣 洋一
  日本口腔科学会雑誌, 73, 1, 34, 34, (NPO)日本口腔科学会, Mar. 2024
  Japanese
• Pre-operative virtual planning followed by fabrication of patient-specific guiding instruments for mandibular deformity after fibula free flap reconstruction
  Ashikaga, Yuichi; Shinohara, Saki; Nakano, Shintaro; Ogawa, Naohiro; Matsuyama, Daigo; Murakami, Hirotake; Kuribayashi, Kazuyo; Ohiro, Yoichi
  Hokkaido journal of dental science, 44, 69, 72, 15 Sep. 2023
  English, Scientific journal, Corrective osteotomy for secondary mandibular reconstruction is complex, and it is extremely difficult to achieve desirable three-dimensional positioning. The authors present a case for repositioning the mandibular segments of mandibular deformity after fibula free flap reconstruction using computer-assisted surgical simulation and patient-specific guiding instruments. A 69-year-old man developed severe mandibular deviation after segmental mandibulectomy and reconstruction with fibula free flap for basal cell carcinoma of the mental region. A virtual osteotomy was performed between the mandible and fibula on a 3D virtual model using simulation software. The proximal mandibular segments were placed in the ideal position using a 3D virtual model. The original contour of the mandible before the primary resection was used as a reference for repositioning. Patient-specific guiding instruments were fabricated for the pre-osteotomy and intraoperative positioning of the osteotomized mandible, enabling bone fragments to be repositioned and fixed using the pre-operative plan. Post-operative CT showed that the mandibular segments were precisely repositioned. In this case, virtual planning and patient-specific guiding instruments were useful in corrective surgery for mandibular deformity after fibula free flap reconstruction.
• 頭頸部アルミノックス治療におけるニードルカテーテル穿刺のためのガイドプレートの製作について
  足利 雄一; 鈴木 崇祥; 若林 侑輝; 格口 渉; 関口 珠希; 栗林 和代; 本間 明宏; 大廣 洋一
  頭頸部癌, 49, 2, 127, 127, (一社)日本頭頸部癌学会, May 2023
  Japanese
• 頭頸部アルミノックス治療におけるニードルカテーテル穿刺のためのガイドプレートの製作について
  足利 雄一; 鈴木 崇祥; 若林 侑輝; 格口 渉; 関口 珠希; 栗林 和代; 本間 明宏; 大廣 洋一
  頭頸部癌, 49, 2, 127, 127, (一社)日本頭頸部癌学会, May 2023
  Japanese
• Significant association of Yamamoto-Kohama classification and pathological depth of invasion with cervical lymph node metastasis in early-stage tongue squamous cell carcinoma (Stage I/II)
  Wataru Kakuguchi; Yuichi Ashikaga; Aya Yanagawa-Matsuda; Kazuyo Kuribayashi; Saki Shinohara; Naohiro Ogawa; Nako Maishi; Kyoko Hida; Chih-Yuan Fang; Yoichi Ohiro
  Journal of Dental Sciences, 18, 4, 1663, 1668, Elsevier BV, Feb. 2023
  Scientific journal
• 舌扁平上皮癌T1-2N0(UICC第8版)におけるリンパ節後発転移の有無に関する臨床病理学的検討
  格口 渉; 足利 雄一; 松田 彩; 栗林 和代; 間石 奈湖; 樋田 京子; 大廣 洋一
  頭頸部癌, 48, 2, 215, 215, (一社)日本頭頸部癌学会, May 2022
  Japanese
• By primary closure with rotative palatal flap, immediate implant placement without good primary stability in a socket with labial cortical plate defects can achieve stable results.
  Monica Wang; Kazuyo Kuribayashi Sato; Yu-Chao Chang; Chih-Yuan Fang
  Journal of dental sciences, 17, 1, 598, 600, Jan. 2022, ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• The volume of proximal bone projection can determine the osseous contour after immediate implant placement and guided bone regeneration in severe labial bony deficiency.
  Monica Wang; Kazuyo Kuribayashi Sato; Lo-Lin Tsai; Wei Jen Chang; Yu-Chao Chang; Chih-Yuan Fang
  Journal of dental sciences, 17, 1, 633, 637, Jan. 2022, ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Anterior immediate implant placement (IIP) has many biological and esthetic challenges, including inevitable soft and hard tissue loss after extraction. Previous literatures have discussed the facial bone architecture and defective socket classification. However, none of them discussed the depression of the cervical root area which can be seen frequently after IIP in type IIB and U-shaped defective sockets. In our limited experiences, we found that the labial interproximal bone edges of type IIB and U-shaped defect dominated the esthetic result after IIP. With more labial projection of the interproximal bone present, better esthetic result could be expected in the facial aspect. With adequate evaluation of this osseous scalloping before IIP, both patient and clinician could have a comprehensive understanding of the final esthetic result. This article also detailed the process of patient selection, diagnosis, surgical options, and executions required to achieve functional and esthetic success with IIP and provisionalization.
• 頸部リンパ節転移を伴った巨大な下顎エナメル上皮癌の1例
  関口 珠希[山田]; 大廣 洋一; 足利 雄一; 佐藤 和代[栗林]; 北村 哲也; 鄭 漢忠
  日本口腔外科学会雑誌, 67, 5, 275, 280, (公社)日本口腔外科学会, May 2021
  Japanese, 症例は54歳男性で、左側下顎部皮膚に小豆大の腫瘤を自覚し、増大傾向にあったため近在皮膚科を受診した。症状に改善がないため某大学病院皮膚科を紹介受診し、腫瘤は下顎骨に関連した病変であると診断され、精査加療目的に当科を紹介受診した。画像所見より下顎骨悪性腫瘍と診断し、両側頸部郭清術、下顎亜全摘術、皮膚部腫瘍合併切除術、遊離腓骨皮弁とチタン製プレートならびに有茎大胸筋皮弁による即時再建術を行った。創部の治癒は問題なく経過したが、術後約1ヵ月のCTで左側頬部皮下に結節が出現した。切除した結果、エナメル上皮癌であった。放射線治療と化学療法を行うも治療効果判定のCTで左側胸膜播種と右側副腎転移を認め、緩和ケアに移行した。腫瘍による気道閉塞が進行し、術後から7ヵ月で死亡した。
• Overexpressed tumor protein p53 and the impaired function in aggressively growing calcifying odontogenic cyst: a case report
  OHIRO Yoichi; KAKUGUCHI Wataru; KAKUGUCHI Wataru; KURIBAYASHI Kazuyo; KITAMURA Tetsuya; TEI Kanchu
  北海道歯学雑誌, 41, 2, 2021
• 上顎歯肉癌に対する術後放射線治療により短期間で発症した放射線誘発と考えられた肉腫の1例
  関口 珠希[山田]; 鄭 漢忠; 大廣 洋一; 栗林 和代; 工藤 章裕; 足利 雄一
  日本口腔腫瘍学会誌, 32, 4, 229, 236, (一社)日本口腔腫瘍学会, Dec. 2020
  Japanese
• New video fluoroscopic chewing examination for patients who use dentures after mandibular reconstruction.
  T Hayashi; K Kuribayashi; T Maeda; Y Yamamoto
  The British journal of oral & maxillofacial surgery, 57, 7, 697, 698, Sep. 2019, [International Magazine]
  English, Scientific journal
• 当院救急科に搬送され医科と連携して対応した広範囲顔面多発骨骨折の治療経験
  松田 光平; 松沢 祐介; 山田 珠希; 格口 渉; 栗林 和代; 大廣 洋一; 鄭 漢忠
  口腔顎顔面外傷, 16, 2, 83, 84, 日本口腔顎顔面外傷学会, Oct. 2017
  Japanese
• Application of vacuum-assisted closure therapy and hyperbaric oxygen therapy for an exposed titanium plate after mandible reconstruction: a case report
  Toshihiko Hayashi; Yuichi Ashikaga; Y. Ohiro; Kanchu Tei; S. Tanaka; Taku Maeda; R. Yoshitatsu; Kazuyo Kuribayashi
  International Journal of Oral and Maxillofacial Surgery, 46, 336, Elsevier BV, 01 Mar. 2017
• Therapeutic strategies for etiologies in the oral and maxillofacial regions
  Kanchu Tei; Yoichi Ohiro; Kazuhiro Matsusita; Yusuke Matsuzawa; Kazuyo Satoh; Tamaki Yamada
  Hokkaido Journal of Dental Science, 38, 151, 156, 北海道歯学会, 2017, [Peer-reviewed]
  English, Scientific journal, In this paper we describe our strategies for treatment of oral cancer, jaw deformity, and odontogenic tumors. Details of the strategy for cleft palate is introduced in a separate report, by Professor Mikoya. Newly applied strategies for patients with post-surgical swallowing dysfunction and dentoalveolar surgery are also introduced. Oral cancer, jaw deformity, cleft, and odontogenic tumors are the main etiologies in the oral and maxillofacial region. Early stages of oral cancer (StageI and StageII) are mainly treated with surgery or radiotherapy alone, and the 5-year survival rate is 80 to 90%. With advanced oral cancer (StageIII and StageIV) a combination of chemotherapy and radiotherapy with or without surgery is the norm, but the 5-year survival rate is below 50% overall. Therefore, there is a need for an effective combination of therapies for advanced oral squamous cell carcinomas. The treatment goal for jaw deformities is to achieve a functional and desirable occlusion. To achieve desirable occlusion, treatment by the team approach is introduced, it includes oral and maxillofacial surgeons, orthodontists, and prosthodontists. A unique method, termed the "Dredging Method" is used in the treatment strategies of odontogenic tumors. The method was introduced to remove all of the tumor and restore the form and function of the jaw through bone generation. The Dredging Method involves four steps: Deflation, Enucleation, Dredging, and Follow up. Tooth autotransplantation in our department stands out in comparison with other facilities in the field of dentoalveolar surgery. The annual number of cases exceeds 150, and up to December of 2015 the total number of cases reached 1,100. The 5-year survival rate for cases with transplanted third molars to the molar region is 86%. Post-surgical swallowing dysfunction is strongly dependent on the extent of the surgery and type of reconstruction. Here, post-surgical swallowing dysfunction can be accurately predicted prior to the surgery, and to develop plans for individual rehabilitation programs to overcome post-surgical swallowing dysfunction is crucial.
• The improvement on swallowing function by wearing denture in the patients received mandibular reconstruction
  Toshihiko Hayashi; Y. Yamzaki; Yuichi Ashikaga; Kazuyo Kuribayashi; H. Hamada; Mitsunobu Ono; Kanchu Tei; Y. Ohiro
  International Journal of Oral and Maxillofacial Surgery, 44, e272, Elsevier BV, 01 Oct. 2015
• 下顎再建後のプレート露出に対するVAC治療システムおよび高気圧酸素療法を用いた集学的治療
  前田 拓; 林 利彦; 古川 洋志; 七戸 龍司; 栗林 和代; 小野 貢伸; 村尾 尚規; 小山 明彦; 舟山 恵美; 山本 有平
  日本マイクロサージャリー学会学術集会プログラム・抄録集, 41回, 166, 166, (一社)日本マイクロサージャリー学会, Dec. 2014
  Japanese
• 下顎骨放射線性骨髄炎に対し下顎骨区域切除を行い自家腸骨移植により下顎骨再建を行った2例
  足利 雄一; 萬 顕; 佐藤 和代; 大廣 洋一; 小野 貢伸; 鄭 漢忠; 戸塚 靖則
  日本口腔科学会雑誌, 58, 4, 281, 281, (NPO)日本口腔科学会, Sep. 2009
  Japanese
• 下顎歯肉扁平上皮癌手術症例の治療成績の検討
  栗林 和代; 小野 貢伸; 足利 雄一; 大廣 洋一; 鄭 漢忠; 佐藤 明; 野谷 健一; 北川 善政; 戸塚 靖則
  頭頸部癌, 35, 2, 127, 127, (一社)日本頭頸部癌学会, May 2009
  Japanese

• Treatment of secondary deformity following free fibula flap mandibule reconstruction using a computer simulation system
  中野晋太郎; 足利雄一; 格口渉; 関口珠希; 栗林和代; 大廣洋一, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 41st, 2023
• 口腔癌に対する治療戦略 進行口腔扁平上皮癌に対する治療法の再考
  上田 倫弘; 林 信; 新山 宗; 栗林 和代; 篠原 早紀; 秦 浩信; 今待 賢治, 日本癌治療学会学術集会抄録集, 59回, SY15, 4, Oct. 2021
  (一社)日本癌治療学会, English
• 当科における舌扁平上皮癌Stage I,II症例の腫瘍の深度と治療成績についての検討
  栗林和代; 山田珠希; 足利雄一; 大廣洋一; 北村哲也; 鄭漢忠, 頭けい部癌, 43, 2, 192, 192, 10 May 2017
  日本頭頸部癌学会, Japanese
• 当科における過去17年間の腺様嚢胞癌症例の臨床的検討
  山田珠希; 足利雄一; 小野貢伸; 栗林和代; 大廣洋一; 鄭漢忠, 頭けい部癌, 43, 2, 252, 252, 10 May 2017
  日本頭頸部癌学会, Japanese
• 当科における口腔扁平上皮癌再発症例の臨床的検討
  足利 雄一; 栗林 和代; 田中 宗一; 大廣 洋一; 小野 貢伸; 鄭 漢忠, 頭頸部癌, 42, 2, 206, 206, May 2016
  (一社)日本頭頸部癌学会, Japanese
• Management of the N0 Neck in Early Stage Oral Squamous Cell Carcinoma
  Mitsunobu Ono; Kazuyo Kuribayashi; Yuichi Ashikaga; Yoichi Ohiro; Kanchu Tei, 北海道歯学雑誌, 36, 2, 128, 133, Mar. 2016
  Management of clinically node negative neck patients with oral squamous cell carcinoma (OSCC) remains controversial. Elective neck dissection (END) is used on an assumption of difficulty in diagnosing subclinical nodal metastases in the neck. This is also the case when early dissection allows better prognosis if nodal metastases actually exist. However, the disadvantage of prophylactic END is that truly N0 neck patients undergo unnecessary neck dissection and have to bear shoulder complaints and dysfunction. Our strategy has been a" wait and see" policy for the management of the neck among patients with T1-2 oral cancer without clinical nodal metastases unless the neck was being opened for reconstruction requirements. The purpose of this study is to assess the outcome of patients who underwent trans-oral tumor excision and" wait-and-see" policy for the N0 neck. A total of 94 previously untreated patients with T1-2N0 classification were investigated. Elective neck dissection (END) was carried out on 10 patients (10.6%) at the time of treatment of the primary resection with reconstruction (END group), and 84 patients were observed without neck dissection (Observation group). The 5-year disease specific survival rates were 90.0% for the END group and 95.9% for the observation group. The 5-year over all survival rates were 90.0% in the END group and 88.8% in the observation group. In the observation group of 84 patients, 16 patients (19.0%) had delayed metastasis in the neck subsequently. 15 patients underwent salvage neck dissection. The salvage rate was 86.6% (13/15 patients). The treatment strategy "wait and see" policy for T1-2N0 OSCC resulted in a good outcome at our institution. Unnecessary neck dissection can be avoided for the truly N0 patients., 北海道歯学会, English
• 当科における口腔扁平上皮癌stage III,IVAの治療成績について
  足利雄一; 栗林和代; 大廣洋一; 小野貢伸; 鄭漢忠, 頭頸部癌, 39, 2, 2013
• 初回治療後20年以上経過して再発した上顎癌の3例
  足利雄一; 栗林和代; 大廣洋一; 小野貢伸; 鄭漢忠; 大森桂一; 中村太保; 進藤正信; 戸塚靖則, 頭頸部癌, 35, 2, 2009
• 片側唇顎口蓋裂患者におけるHotz床装着中止の要因について
  伊藤 裕美; 高師 則行; 三古谷 忠; 松沢 祐介; 熊澤 龍一郎; 三嶋 博之; 栗林 和代; 井上 農夫男; 戸塚 靖則, 日本口腔外科学会雑誌, 47, 13, 1049, 1049, Dec. 2001
  (公社)日本口腔外科学会, Japanese
• Hotz床による哺乳障害改善までの期間に影響する因子について
  高師 則行; 伊藤 裕美; 三古谷 忠; 松沢 祐介; 熊澤 龍一郎; 三嶋 博之; 栗林 和代; 井上 農夫男; 戸塚 靖則, 日本口腔外科学会雑誌, 47, 13, 1048, 1048, Dec. 2001
  (公社)日本口腔外科学会, Japanese
• 顎裂部骨移植部への自家歯牙移植により咬合再建を行った2症例
  松沢 祐介; 三嶋 博之; 三古谷 忠; 栗林 和代; 高師 則行; 伊藤 裕美; 出山 文子; 井上 農夫男; 熊沢 龍一郎; 戸塚 靖則, 日本口蓋裂学会雑誌, 26, 2, 242, 242, Apr. 2001
  (一社)日本口蓋裂学会, Japanese
• 外側舌リンパ節転移が疑われた舌癌の1例
  栗林和代, 日口外誌, 46, 11, 736, 736, 2000

• Our strategy for oral cancer and post-operative swallowing dysfunction
  Kazuyo Kuribayashi
  TIMNAS8 Faculty of Dental Medicine Airlangga University, 28 Feb. 2020, English, Invited oral presentation
  27 Feb. 2020 - 29 Feb. 2020, [Invited]
• 下顎歯肉扁平上皮癌手術症例の治療成績の検討
  栗林 和代; 小野 貢伸; 足利 雄一; 大廣 洋一; 鄭 漢忠; 佐藤 明; 野谷 健一; 北川 善政; 戸塚 靖則
  頭頸部癌, May 2009, (一社)日本頭頸部癌学会, Japanese
  May 2009 - May 2009

• 口腔顎顔面外科学, 2024年, 博士後期課程, 歯学院
• 口腔病態学実習Ⅴ, 2024年, 博士後期課程, 歯学院
• 口腔病態学実習Ⅰ, 2024年, 博士後期課程, 歯学院
• 口腔顎顔面外科学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔病態学実習Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔病態学実習Ⅲ, 2024年, 博士後期課程, 歯学院
• 口腔病態学実習Ⅳ, 2024年, 博士後期課程, 歯学院
• 口腔生物学と医学, 2024年, 博士後期課程, 歯学院
• 口腔生物学と医学, 2024年, 博士後期課程, 歯学院
• 歯科学概論Ⅱ, 2024年, 学士課程, 歯学部
• 外科学, 2024年, 学士課程, 歯学部
• 口腔顎顔面外科学臨床実習Ⅱ, 2024年, 学士課程, 歯学部
• 口腔顎顔面外科学臨床実習Ⅰ, 2024年, 学士課程, 歯学部
• 口腔顎顔面外科学, 2024年, 学士課程, 歯学部

• 2021 - Present
  日本癌治療学会

• Identification of tumor vascular miRNA and application to cancer diagnosis and therapy
  Grants-in-Aid for Scientific Research
  01 Apr. 2015 - 31 Mar. 2017
  Sato (Kuribayashi) Kazuyo
  In this study, we have tried to identify miRNAs which are involved in tumor vessel abnormality and to evaluate their roles in tumor invasion and metastasis, in order to develop novel cancer diagnostics and therapy. Endothelial cells were treated by cancer-derived exosome. Several miRNAs were upregulated and their function were analyzed. Using miRNA database, the target gene of these miRNAs were picked up and the involvement of these target molecule in tumor vessel abnormality were addressed.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 15K15726