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koichi nakamura

Faculty of Dental Medicine　Division of Dental Medicine　Department of Functional ScienceProfessor
Hokkaido University HospitalProfessor

Researcher basic information

■ Degree
  • 博士（歯学）, 北海道大学
■ URL
researchmap URLホームページURL■ Various IDs
J-Global ID■ Research Keywords and Fields
Research Field
  • Life Science, Developmental dentistry
  • Life Science, Regenerative dentistry and dental engineering
■ Educational Organization

Career

■ Career
Career
  • Apr. 2026 - Present
    Hokkaido University, Graduate School of Dental Medicine, 教授
  • Apr. 2025 - Mar. 2026
    Hokkaido University, Hokkaido University Hospital, 講師
  • Jun. 2012 - Mar. 2025
    北海道大学 歯学研究科(研究院), 助教
Committee Memberships
  • Apr. 2026 - Present
    日本小児歯科学会, 理事
  • Aug. 2025 - Present
    日本歯科医学教育学会, 代議員

Research activity information

■ Papers
  • Promoting Dentin Bridge Formation Through N-Acetyl-L-Cysteine Application in Rat Molar Pulpotomy: An Experimental Study
    Kota Takagi; Koichi Nakamura; Yoshitaka Yoshimura; Yasutaka Yawaka
    Journal of Functional Biomaterials, 16, 4, 117, 117, MDPI AG, 27 Mar. 2025
    Scientific journal, Pulpotomy is performed when tooth decay reaches the dental pulp or when the crown is fractured due to trauma. Mineral trioxide aggregate (MTA) is commonly used in pulpotomy, but its prognosis can be variable. N-acetyl-L-cysteine (NAC), an antioxidant amino acid, has garnered attention due to its potential benefits. This study aimed to investigate the effects of MTA and NAC on pulpotomy outcomes. We used Sprague Dawley rat maxillary molars to perform pulpotomy and employed Superbond C&B, MTA, and MTA mixed with NAC (MTA–NAC) for pulp capping. We obtained tissue sections 3 and 7 days postpulpotomy, conducting histological analysis by examining the morphology of pulp tissue and assessing dentin sialophosphoprotein (DSPP) and osteopontin expression levels. At 3 days postpulpotomy, MTA and MTA–NAC reduced the inflammatory response. At 7 days postpulpotomy, dentin bridge formation was observed following MTA–NAC application, and although MTA resulted in DSPP- and osteopontin-positive areas, these areas were more extensive following MTA–NAC application. Given that adding NAC to MTA enhanced dentin bridge formation, MTA–NAC appears to be a superior option for pulp capping.
  • 症候性全般てんかんの女児にみられた原因不明の歯肉増殖により乳歯の萠出に障害をきたした症例(第1報)
    中村 光一; 趙 継美; 八若 保孝
    障害者歯科, 45, 3, 159, 164, (公社)日本障害者歯科学会, Oct. 2024, [Peer-reviewed], [Lead author]
    Japanese
  • 当大学病院小児・障害者歯科外来における2016年から5年間の新規来院患者の実態調査
    趙 継美; 高木 康多; 高橋 静香; 竹渕 塁; 中村 光一; 八若 保孝
    小児歯科学雑誌, 61, 3, 110, 116, (公社)日本小児歯科学会, Nov. 2023, [Peer-reviewed]
    Japanese
  • スペシャルオリンピックス日本・北海道EKSDAY2022ヘルシー・アスリート・プログラム スペシャルスマイルズの活動概要と健診結果
    中村 光一; 鈴木 翔斗; 高木 康多; 那須 結菜; 三浦 真理; 村井 裕子; 日原 加代; 小森 さやか; 石川 佳恵; 島田 裟彩; 江草 正彦; 小笠原 正; 八若 保孝
    日本障害者歯科学会総会および学術大会プログラム・抄録集, 40回, 180, 180, (公社)日本障害者歯科学会, Oct. 2023
    Japanese
  • N-acetylcysteine attenuates PGE2 and ROS production stimulated by 4-META/MMA-based resin in murine osteoblastic cells.
    Koichi Nakamura; Hajime Minamikawa; Shizuka Takahashi; Yoshitaka Yoshimura; Yasutaka Yawaka
    Dental materials journal, 40, 3, 808, 812, 29 May 2021, [Peer-reviewed], [Lead author], [Domestic magazines]
    English, Scientific journal, This study examined the effects of N-acetylcysteine (NAC) on the inflammatory reactions of murine osteoblastic cells cultured on the 4-methacryloxyethyl trimellitate anhydride/methyl methacrylate (4-META/MMA)-based resin. Superbond C&B (SB) was used as the 4-META/MMA-based resin and placed in a 48-well cell culture plate. The cells were cultured in αMEM (control) as well as on SB and SB in αMEM with NAC (SB+NAC). They were examined using the WST-1 proliferation assay, real-time PCR, enzyme-linked immunosorbent assay (ELISA), intracellular reactive oxygen species (ROS) measurements, and cellular glutathione (GSH) detection. COX-2 and IL-6 gene expressions were upregulated in SB; however, they were suppressed by NAC. Furthermore, PGE2 production in the culture medium was increased in SB, whereas NAC decreased the PGE2 production. NAC lowered the ROS level in the culture medium and significantly increased the intracellular GSH level. The present in vitro study demonstrated that NAC might be effective for dental material detoxification.
  • 当大学病院における小児・障害者歯科外来の新規来院患者についての実態調査
    前田 彩子; 久田 明奈; 星野 恵; 岩寺 信喜; 種市 梨紗; 中村 光一; 高崎 千尋; 八若 保孝
    小児歯科学雑誌, 58, 3, 149, 156, (公社)日本小児歯科学会, Nov. 2020, [Peer-reviewed]
    Japanese
  • Effects of N-acetylcysteine on root resorption after tooth replantation
    Nishimi Mitsuhiko; Nakamura Koichi; Hisada Akina; Endo Kazuki; Ushimura Shuya; Yoshimura Yoshitaka; Yawaka Yasutaka
    Pediatric Dental Journal, 30, 2, 72, 79, Elsevier, Aug. 2020, [Peer-reviewed], [Corresponding author]
    English
  • 自動pHサイクル装置を用いた歯冠修復材料の脱灰抑制の影響
    遠藤 一樹; 中村 光一; 八若 保孝
    北海道歯学雑誌, 39, 2, 87, 93, 北海道歯学会, Mar. 2019, [Peer-reviewed]
    Japanese
  • Calcium Charge and Release of Conventional Glass-Ionomer Cement Containing Nanoporous Silica.
    Nakamura K; Abe S; Minamikawa H; Yawaka Y
    Materials (Basel, Switzerland), 11, 8, Jul. 2018, [Peer-reviewed], [Lead author]
  • 重症心身障害児の保護者による在宅での口腔ケアにおける清拭の有効性
    高井理人; 高井理人; 大島昇平; 中村光一; 八若保孝
    障害者歯科, 39, 1, 1‐7, 7, The Japanese Society for Disability and Oral Health, 28 Feb. 2018, [Peer-reviewed]
    Japanese,

    Purpose：To clarify the effectiveness of wiping during oral care by guardians at home, and factors associated with salivary bacterial count.

    Method：The participants were 20 children with severe motor and intellectual disabilities （SMID） （mean age 5.5±3.8 years old） requiring both mechanical ventilator and tube-feeding. The survey was conducted during home-visit dental treatment. Guardians were instructed to do oral care （brushing their children's teeth for 2 minutes and wiping the inside of the oral cavity with gauze）. They were taught how to wipe before oral care. Suction during brushing was carried out in case guardians performed brushing on a daily basis. The saliva was taken from the floor of the mouth, and the number of bacteria in saliva was measured by a bacteria detection apparatus （Panasonic Healthcare Co., Ltd.）. Collection and measurement were conducted before brushing, after brushing, and after wiping. The correlations between the number of bacteria taken before brushing and information regarding patient characteristics such as method of feeding, use of mechanical ventilator, existence of tracheostomy, existence of continuous suction, and existence of swallowing were examined statistically.

    Results：The number of bacteria in saliva decreased significantly from before and after brushing to after wiping. There was no significant correlation between the existence of suction during brushing and variation of salivary bacterial count before and after brushing. The independent variables shown by univariate analysis to have a significant relationship with salivary bacterial count before brushing were use of mechanical ventilator, existence of tracheostomy, and existence of swallowing. Multiple regression analysis identified existence of swallowing as an independent associated factor for salivary bacterial count.

    Conclusion：Wiping was an effective method to decrease bacteria after brushing. Children who do not swallow had larger numbers of bacteria in saliva before brushing. These findings indicated that it is important for children who do not swallow to have their oral cavity wiped after tooth-brushing.

  • Estimation of controlled drug-release behavior of nano-porous silica micro particles and their biocompatibility
    Eri Seitoku; Yuko Era; Ko Nakanishi; Yosuke Bando; Shinichi Kakuda; Koichi Nakamura; Teruo Kusaka; Shigeaki Abe; Mariko Nakamura; Yasutaka Yawaka; Junichiro Iida; Yasuhiro Yoshida; Hidehiko Sano
    Nano Biomedicine, 9, 2, 112, 116, National Institute of Informatics, 2018, [Peer-reviewed]
    English, Scientific journal
  • Charge and controlled release of epigallocatechin gallate by glass ionomer cement containing nanoporous silica particles
    Koichi Nakamura; Ko Nakanishi; Yosuke Bando; Akira Hasebe; Atsushi Hyono; Shigeaki Abe; Ken-Ichiro Shibata; Yasuhiro Yoshida; Junichiro Iida; Yasutaka Yawaka
    Nano Biomedicine, 9, 1, 29, 34, National Institute of Informatics, 2018, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Home-visit Dental Treatments for Children with Severe Motor and Intellectual Disabilities Requiring Home Mechanical Ventilator
    高井理人; 高井理人; 大島昇平; 中村光一; 八若保孝
    小児歯科学雑誌, 55, 3, 382‐389, 389, Japanese Society of Pediatric Dentistry, 25 Jun. 2017, [Peer-reviewed]
    Japanese,

    In recent years, the number of children with severe motor and intellectual disabilities who live at home has been increasing. Although most require medical care such as tube feeding or a mechanical ventilator, the present level of medical support for disabled children living at home is not adequate. We investigated this situation, and evaluated the effectiveness of home-visit dental treatments for children with severe motor and intellectual disabilities who require a mechanical ventilator.

    The subjects were 27 patients (≤15 years old, mean age 4.7±4.0 years) with severe motor and intellectual disabilities, and who required a home mechanical ventilator and received home-visit dental treatments provided by Toseikai Healthcare Corporation Life-Long Care Clinic for Disabled people from April 2015 to December 2016. We compiled information regarding basic patient characteristics, oral condition and function, and contents of the home-visit treatments. All were receiving multiple types of medical support. Nineteen patients were using a tracheostomy ventilator and 8 a nasal mask ventilator, while 22 received nutrition via a gastrostomy, 4 from naso-enteric feeding, and 1 from oral intake. Several had gingivitis or calculus deposition, and their oral functions were severely disordered. As for dental treatments, we mainly conducted oral care instruction and dysphagia rehabilitation. In cases that were difficult to treat at home, we cooperated with the related hospital. Most of the patients had no experience with visiting a dentist or had quit regular dental visits, though they were able to receive regular oral management through our home-visit dental treatment program. Our findings indicated that home-visit dental treatments are effective for children with severe motor and intellectual disabilities living at home and using a mechanical ventilator.

  • Effect of fluoride-releasing fissure sealants on enamel demineralization
    Koichi Nakamura; Shigeaki Abe; Hajime Minamikawa; Yasutaka Yawaka
    Pediatric Dental Journal, 27, 1, 56, 64, Elsevier Ltd, 01 Apr. 2017, [Peer-reviewed], [Lead author]
    English, Scientific journal
  • Assessment of the inhibitory effects of fissure sealants on the demineralization of primary teeth using an automatic pH-cycling system.
    Shuya Ushimura; Koichi Nakamura; Yasuhiro Matsuda; Hajime Minamikawa; Shigeaki Abe; Yasutaka Yawaka
    Dental materials journal, 35, 2, 316, 24, 2016, [Peer-reviewed], [Corresponding author], [Domestic magazines]
    English, Scientific journal
  • Simple and Rapid Conductive Preparation of Wet Biological Samples for SEM Observation: Use of an Asymmetrical Choline-like Room Temperature Ionic Liquid as a Visualizing Agent
    ABE SHIGEAKI; HYONO ATSUSHI; KAWAI KOJI; NAKAMURA KOICHI; YAWAKA YASUTAKA; YOSHIDA YASUHIRO; YONEZAWA TETSU
    Nano Biomed, 6, 1, 41, 46, 30 Jun. 2014, [Peer-reviewed]
    English
  • フッ素徐放性ブラケット接着材のヒトエナメル質接着とフッ素のリリースならびにリチャージについて
    中村 光一; 野村 奈央子; 豊田 有希; 南川 元; 加我 正行; 八若 保孝
    小児歯科学雑誌, 48, 1, 73, 80, (公社)日本小児歯科学会, Mar. 2010, [Peer-reviewed], [Lead author]
    Japanese, フッ素徐放性矯正用ブラケット接着材を用いて、ヒトエナメル質とブラケットの接着力、接着材からのフッ素のリリースならびにリチャージ性能を検討した。対象はビューティオーソボンド、ビューティオーソボンドサリバテクト併用(サリバテクト併用)、クラスパーF、スーパーボンドオルソマイト、フジオルソLCの5種類であり、せん断接着強さ試験の結果、いずれの接着材も必要十分な7.4〜16.7MPaの接着力を有しており、中でもフジオルソLC、ビューティオーソボンド、サリバテクト併用はフッ素のリリースならびにリチャージ性能を有することが確認された。フッ素徐放性ブラケット接着材は適度な接着力、持続的なフッ素のリリース、歯面処理による歯質表面の損傷が少ないことなどから、齲蝕誘発環境が避けられない咬合誘導治療における齲蝕予防に有効であることが示唆された。
  • Tooth Adhesion and Fluoride Release of Paste/paste Mixed Type Glass Ionomer Cement
    KAGA MASAYUKI; IWABUCHI HIDEAKI; NAKAMURA KOICHI; HASHIMOTO MASANORI; YAWAKA YASUTAKA
    小児歯科学雑誌, 45, 1, 81, 87, 25 Mar. 2007, [Peer-reviewed]
    Japanese
■ Other Activities and Achievements
■ Syllabus
  • 口腔機能学実習Ⅰ, 2024年, 博士後期課程, 歯学院
  • 口腔機能学実習Ⅱ, 2024年, 博士後期課程, 歯学院
  • 口腔機能学実習Ⅲ, 2024年, 博士後期課程, 歯学院
  • 口腔機能学実習Ⅳ, 2024年, 博士後期課程, 歯学院
  • 口腔機能学実習Ⅴ, 2024年, 博士後期課程, 歯学院
  • 小児歯科学, 2024年, 博士後期課程, 歯学院
  • 咬合発達学, 2024年, 博士後期課程, 歯学院
  • 咬合発達学, 2024年, 博士後期課程, 歯学院
  • 小児口腔機能回復学研究Ⅰ, 2024年, 博士後期課程, 歯学院
  • 小児口腔機能回復学研究Ⅱ, 2024年, 博士後期課程, 歯学院
  • 小児口腔発育学研究Ⅰ, 2024年, 博士後期課程, 歯学院
  • 小児口腔発育学研究Ⅱ, 2024年, 博士後期課程, 歯学院
  • 小児口腔細胞分子生物学研究Ⅰ, 2024年, 博士後期課程, 歯学院
  • 基本技法, 2024年, 博士後期課程, 歯学院
  • 小児歯科学臨床実習Ⅰ, 2024年, 学士課程, 歯学部
  • 小児歯科学臨床実習Ⅱ, 2024年, 学士課程, 歯学部
  • 障害者歯科学, 2024年, 学士課程, 歯学部
  • 小児歯科学基礎実習, 2024年, 学士課程, 歯学部
■ Affiliated academic society
  • 日本口蓋裂学会
  • 日本歯科医学教育学会
  • 日本障害者歯科学会
  • 日本小児歯科学会
■ Research Themes
  • 温度応答性ポリマーを用いた生体吸収性乳歯根管充填材の創製
    科学研究費助成事業
    01 Apr. 2025 - 31 Mar. 2028
    中村 光一; 阿部 薫明; 八若 保孝
    日本学術振興会, 基盤研究(C), 北海道大学, 25K13261
  • Control of complicated root canal system of primary teeth: Reproduction of resorbed part of outer root surface
    Grants-in-Aid for Scientific Research
    01 Apr. 2024 - 31 Mar. 2027
    八若 保孝; 中村 光一
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 24K13167
  • 生活歯髄切断材料に対する抗酸化アミノ酸の応用~強アルカリによる歯髄刺激からの脱却
    科学研究費助成事業 基盤研究(C)
    01 Apr. 2022 - 31 Mar. 2025
    中村 光一; 阿部 薫明; 八若 保孝
    本研究はMTAセメントをベースとして、NAC（N-アセチルシステイン）を利用し、細胞刺激性が弱く、石灰化誘導作用を有するセメントの開発を目標とした。
    ラットの生活歯髄切断（生切）後に、HE染色、免疫組織染色を行なった。MTAセメント（MTA)ならびにMTAセメントにNACを配合したもの（MTA-NAC)で覆髄した。上部はスーパーボンドで封鎖した。コントロールはスーパーボンドで直接封鎖した。生切3日後、7日後にラット臼歯を摘出し、組織を脱灰、固定し、薄切切片を作製し、各染色を行なった。生切3日後のHE染色の結果、コントロールでは根管上部に炎症性細胞の浸潤が認められた。MTAでは歯髄切断面直下に炎症性細胞浸潤が認められ、MTA-NACでは同部位に軽度の炎症性細胞浸潤が認められた。DSPP染色の結果、コントロールとMTAではDSPP陽性部位は認められなかった。一方でMTA-NACでは歯髄切断面直下にDSPP陽性部位が認められた。Osteopontin染色の結果、コントロールではOsteopontin陽性部位は認められなかった。MTAでは歯髄切断面直下にOsteopontin陽性部位が認められ、MTA-NACでは根管上部にOsteopontin陽性部位が認められた。7日後のHE染色の結果、コントロールでは根管上部に炎症性細胞浸潤が認められた。MTAとMTA-NACでは歯髄切断面直下に軽度の炎症性細胞浸潤が認められた。DSPP染色の結果、コントロールではDSPP陽性部位は全く認められなかった。MTAでは歯髄切断面直下にDSPP陽性部位を認めた。MTA-NACは広範囲でDSPP陽性部位を認めた。Osteopontin染色の結果、コントロールでは歯髄切断面直下にOsteopontin陽性部位が認められた。MTAとMTA-NACでは根管上部にOsteopontin陽性部位が認められた。
    日本学術振興会, 基盤研究(C), 北海道大学, 22K10259
  • Do Hg, Pb, and Al exposures effect development of non-cognitive and prefrontal function?
    Grants-in-Aid for Scientific Research
    01 Apr. 2020 - 31 Mar. 2024
    KUSANAGI Emiko
    This longitudinal study measured participants' exposure to toxic and essential metals during adolescence, as well as their home environment and nutritional intake, to examine the effects on their temperament, executive function, behavioral difficulties, and motor functions. The development of effortful control (EC) during adolescence was observed to be negatively related to mercury exposure in early childhood. Emotional problems were positively related to mercury exposure during the fetal period and infancy. Adolescent selenium exposure was positively related to executive function. In boys, aluminum exposure during adolescence was negatively related to EC, and lead exposure in early childhood was negatively related to fine motor development, indicating a higher susceptibility of boys to toxic metals. Children's difficulties were more strongly related to their EC than to parenting behaviors. The intake of essential metals and nutrients was considered important for the development of EC.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Kokugakuin University Hokkaido Junior College, 20H01664
  • Control of complicated root canal system of primary teeth: Induction of repair mechanisms on resorbed part of outer root surface and acquisition of tooth root stability.
    Grants-in-Aid for Scientific Research
    01 Apr. 2020 - 31 Mar. 2023
    Yawaka Yasutaka
    Regarding the root canal treatments, it was showed that the important factors of the control of complicated root canal system of primary teeth were the root canal irrigation with ultrasonic and the root canal medication by calcium hydroxide (Ca(OH)2). In rat root resorption model in animal experiment, we can show the effects of Ca(OH)2 showed inhibition of root outer resorption and occurrence of cementum deposition. We think cementum deposition is one of repair mechanisms on resorbed part.
    We could construct a root resorption model in cell culture. But we cannot reach the step as to investigate effects of Ca(OH)2 due to bad reproducibility of alkalinity diffusion.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 20K10197
  • Making pulp capping materials using epigallocatechin-3-gallate
    Grants-in-Aid for Scientific Research
    01 Apr. 2019 - 31 Mar. 2022
    Nakamura Koichi
    After adding LPS and HEMA stimulation to RAW264.7 cell, and performing WST-8 assay, EGCG did not affect it for cell proliferation. EGCG reduced PGE2 production induced by LPS and HEMA. As the result of pulpotomy, EGCG attenuated recalcification.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 19K10374
  • Control of complicated root canal system of primary teeth: Clarification of reliable method for root resorption control and repair mechanism on resorbed part
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    01 Apr. 2017 - 31 Mar. 2020
    YAWAKA YASUTAKA
    Regarding the root canal treatments, it was showed that the important factors of the control of complicated root canal system of primary teeth were the root canal irrigation with ultrasonic and the root canal medication by calcium hydroxide (Ca(OH)2).
    We constructed a root resorption model in rat molar in animal experiment, and observed histologically the effects of Ca(OH)2 on root resorption. The effects of Ca(OH)2 showed inhibition of root resorption and occurrence of cementum deposition. We think cementum deposition is one of repair mechanisms on resorbed part.
    We could construct a root resorption model in cell culture. But we do not reach the step as to investigate effects of Ca(OH)2 due to bad reproducibility.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 17K11951
  • Development of the dental pulpotomy materials applying polyphenol
    Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    01 Apr. 2015 - 31 Mar. 2018
    Nakamura Koichi
    This study was intended to develop vital pulpotomy materials using catechin. I performed pulpotomy for the maxillary molar of the SD rat. I added epigallocatechin gallate of each density in zinc oxide eugenol cement after cutting in tooth coronal pulp under general anesthesia and covered the section. The change of the cell permeation more inflammatory than control (0% of catechin density) was slight with 0.1% of catechin density. The inflammatory cell permeation decreased in 1.0% of catechin density and 5.0%. I examined antibacterial action for Streptococcus mutans successively. In the case of 0.01%, it was restrained about half of degree quantity of bacteria culture 24 and 48 hours later the density of catechin.
    Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 15K20575
  • Control of complicated root canal system of primary teeth: Examination on ion diffusion of calcium hydroxide and effectiveness of outer root resorption control
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    01 Apr. 2013 - 31 Mar. 2016
    YAWAKA YASUTAKA; NAKAMURA Koichi
    Removal of smear layer and opening of dentinal tubules on root canal surface with root canal irrigation is important factor on good convalescence of root canal treatment. Regarding the root canal irrigation, it was showed that combination of EDTA and NaOCl with ultrasonic was effective in removing the smear layer on permanent teeth, and NaOCl with ultrasonic was effective on primary teeth.
    This study investigated ion diffusion from calcium hydroxide (Ca(OH)2) through the root dentin of extracted human teeth. It was suggested that the smear layer removal and opened dentinal tubules by root canal irrigation with ultrasonic was valid for the alkaline diffusion from Ca(OH)2 to outer root surface. Moreover, it was showed that calcium ion diffused to the outer root surface from root canal. Therefore, it was suggested that the good condition with smear layer removal and opened dentinal tubules by root canal irrigation facilitated the effectiveness of Ca(OH)2 as the root canal medication.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 25463164
  • Fundamental research on the material development of high biocompatibility applying tannic acid
    Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    01 Apr. 2012 - 31 Mar. 2014
    NAKAMURA Koichi
    Glass ionomer cement have a fluoride-releasing.It is said that pulp affinity is high. At first, We examined for the presence of cytotoxic.It was found that COX-2 mRNA expression was induced by cement elution.Tannic acid suppressed the phenomenon. The increased expression of COX-2 mRNA and protein and the production of PGE2 by cement elution. Furthermore, activation of intracellular signal transduction systems present in the upstream was observed. Tannic acid was found to suppress them.
    Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 24792128