博士（歯学）, 岡山大学

feeding behavior

area postrema

nausea, emesis

limbic system

機能系基礎歯科学

Oral physiology

Life Science, Oral biological science, Physiology, Oral physiology

Bachelor's degree program, School of Dental Medicine

Doctoral (PhD) degree program, Graduate school of Dental Medicine

Sep. 2001, Japanese Association for Oral Biology, Award from Japanese Association for Oral Biology
Propagation of synchronous burst discharges from entorhinal cortex to morphologically and electrophysiologically identified neurons of rat lateral amygdala
Funahashi Makoto

Neural responses prior to licking onset in the striatal matrix compartment in mice
Yuta Ishimaru; Tomohiko Yoshizawa; Taishi Kimoto; Tadashi Inui; Yasutaka Yawaka; Makoto Funahashi
Neuroscience, Elsevier BV, Oct. 2025
Scientific journal

Basolateral amygdala inhibition reduces avoidance in conditioned taste aversion—Transient chemogenetic silencing shifts behavior toward sustained licking
Tadashi Inui; Emi Kikuchi; Yuto Suzuki; Momoko Hasegawa; Zimo Wei; Helai Huang; Tomohiko Yoshizawa; Makoto Funahashi
Behavioural Brain Research, 495, 115784, 115784, Elsevier BV, 08 Apr. 2025, [Peer-reviewed], [Last author]
English, Scientific journal

Taste preference and conditioned taste aversion of the metallothionein-1/2 null mice
Nanae Yasuura; Tadashi Inui; Tomohiko Yoshizawa; Norio Sogawa; Yoshiaki Sato; Makoto Funahashi
Physiology & Behavior, 114757, Elsevier BV, Jan. 2025, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal

Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice
Tomohiko Yoshizawa; Makoto Funahashi
Neuroscience Research, Elsevier BV, Nov. 2024, [Peer-reviewed], [Last author]
Scientific journal

Conditioned nausea induced by cisplatin and emetine identified by a taste reactivity test in rats.
Shaoyi Su; Zimo Wei; Helai Huang; Tomohiko Yoshizawa; Tadashi Inui; Makoto Funahashi
Physiology & Behavior, 114278, 114278, Elsevier BV, Jun. 2023, [Peer-reviewed], [Last author, Corresponding author]
Scientific journal

Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia
Tomohiko Yoshizawa; Yuuto Miyamura; Yuta Ochi; Riichiro Hira; Makoto Funahashi; Yutaka Sakai; Yilong Cui; Yoshikazu Isomura
bioRxiv (preprint), Mar. 2023, [Peer-reviewed]
English, Scientific journal

Chemogenetic inhibition of the bed nucleus of the stria terminalis suppresses the intake of a preferable and learned aversive sweet taste solution in male mice.
Emi Kikuchi; Tadashi Inui; Shaoyi Su; Yoshiaki Sato; Makoto Funahashi
Behavioural brain research, 439, 114253, 114253, 15 Feb. 2023, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal, Conditioned taste aversion (CTA) is established by pairing a taste solution as a conditioned stimulus (CS) with visceral malaise as an unconditioned stimulus (US). CTA decreases the taste palatability of a CS. The bed nucleus of the stria terminalis (BNST) receives taste inputs from the brainstem. However, the involvement of the BNST in CTA remains unclear. Thus, this study examined the effects of chemogenetic inhibition of the BNST neurons on CS intake after CTA acquisition. An adeno-associated virus was microinjected into the BNST of male C57/BL6 mice to induce the inhibitory designer receptor hM4Di. The mice received a pairing of 0.2% saccharin solution (CS) with 0.3 M lithium chloride (2% BW, intraperitoneal). After conditioning, the administration of clozapine-N-oxide (CNO, 1 mg/kg) significantly enhanced the suppression of CS intake on the retrieval of CTA compared with its intake following saline administration (p < 0.01). We further assessed the effect of BNST neuron inhibition on the intake of water and taste solutions (saccharin, sucralose, sodium chloride, monosodium glutamate, quinine hydrochloride, and citric acid) using naïve (not learned CTA) mice. CNO administration significantly decreased the intake of saccharin and sucralose (p < 0.05). Our results indicate that BNST neurons mediate sweet taste and regulate sweet intake, regardless of whether sweets should be ingested or rejected. BNST neurons may be inhibited in the retrieval of CTA, thereby suppressing CS intake.

Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats.
Shaoyi Su; Mayu Fujita; Zimo Wei; Helai Huang; Tomohiko Yoshizawa; Tadashi Inui; Makoto Funahashi
Physiology & Behavior, 241, 113565, 113565, Elsevier BV, Nov. 2021, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
English, Scientific journal, We investigated the effect of area postrema lesions and selective vagotomy of afferent fibers on emetine-induced nausea in rats. We evaluated the acquisition of the conditioned taste avoidance (CTA) to 0.1% saccharin solution after conditioning with emetine dihydrochloride (5.54 mg/kg, i.p., 1% BW). The CTA was measured in three groups of rats: a bilateral subdiaphragmatic afferent vagotomy group, an area postrema lesion group, and a sham lesion group. The bilateral vagotomy and sham groups of rats showed acquisition of CTA within 2 days of the test date. Taste avoidance was never conditioned in the area postrema lesion group. These results indicate that the area postrema plays a crucial role in the induction of emetine-induced nausea., 11072316

Involvement of the area postrema and the nucleus tractus solitarius in the emetogenic action of emetine in rats
Takanori Sato; Yoshiyuki Hirai; Shaoyi Su; Wei Zimo; Nanae Yasuura; Tadashi Inui; Makoto Funahashi
Journal of Oral Biosciences, 62, 4, 310, 314, Elsevier BV, Dec. 2020, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal

Effects of methyl methacrylate on the excitability of the area postrema neurons in rats
Tomohiko Yoshizawa; Makoto Funahashi
Journal of Oral Biosciences, 62, 4, 306, 309, Elsevier BV, Dec. 2020, [Peer-reviewed], [Last author], [International Magazine]
English, Scientific journal, OBJECTIVES: The aim of the present study is to demonstrate the effects of inhaled methyl methacrylate (MMA) on the excitability of neurons in the area postrema (AP). We also investigated the relation between vagal afferent inputs and responding cells in the AP. METHODS: We set up two groups of experimental animals, such as rats inhaling MMA and rats inhaling room air. To visualize the changes of AP neuron excitability after inhalation of MMA for 90 min, c-Fos protein expression was identified and quantified by immunohistochemical analysis. Some rats receiving ventral gastric branch vagotomy were also subjected to the abovementioned experiment. RESULTS: The number of c-Fos-immunoreactive (Fos-ir) cells in the MMA group was more than six times greater than that of the control group (statistically significant, p < 0.01). In vagotomized rats inhaling MMA, markedly smaller number of Fos-ir cells was identified in the AP compared to that of rats inhaling MMA without vagotomy. CONCLUSIONS: These results indicate that inhalation of MMA increases neuronal excitability in the AP, suggesting that vagal afferent inputs are involved in the induction mechanism of Fos-ir cells by MMA.

経管栄養時の血糖調節に関する基礎的研究—味覚，嗅覚，視覚が血糖動態に与える影響―
北海道歯学雑誌, 40, 2, 114, 121, Mar. 2020, [Peer-reviewed], [Last author]
Japanese, Scientific journal

Entrainment of chewing rhythm by gait speed during treadmill walking in humans.
Hitoshi Maezawa; Satoko Koganemaru; Masao Matsuhashi; Masayuki Hirata; Makoto Funahashi; Tatsuya Mima
Neuroscience research, 156, 88, 94, 22 Feb. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, It remains unclear whether the rhythmic processes of chewing and gait synchronize during concurrent execution in humans. To evaluate the entrainment of chewing rhythm by gait speed, we measured electromyography from the masseter and tibialis anterior muscles during chewing at a habitual rhythm while walking on a linear treadmill in 12 healthy volunteers. Vertical movement of the head was also measured using an accelerometer. Each 5-min session included gait tasks using a treadmill at three speeds: Auto: the participant's self-selected gait speed, High: Auto × 1.3, and Low: Auto ÷ 1.3. Electromyography from the masseter muscles were also measured during chewing while stationary (Chew-Only). Chewing rhythm during walking was the same as that for head movement, occurring at twice the speed of the walking rhythm, in nine participants (Low), eight participants (Auto), and eight participants (High). For these participants, chewing rhythm in the Auto and High conditions differed significantly from that in the Chew-Only condition. Significant differences in chewing rhythm were also observed among gait speeds (Low vs. Auto vs. High). Our findings demonstrate that entrainment of habitual chewing rhythm to gait speed is a significant phenomenon, and that the dominant ratio of chewing-walking-head movement rhythms is 2:1:2.

エメチン誘発の悪心に対する迷走神経切除と最後野損傷の影響
舩橋 誠; 平井 喜幸; 藤田 麻由; 久留 和成; 前澤 仁志
Journal of Oral Biosciences Supplement, 2018, 391, 391, (一社)歯科基礎医学会, Sep. 2018
Japanese

孤束核および最後野のニューロン活動に対する血糖値上昇の影響
播磨 美樹; 久留 和成; 平井 喜幸; 前澤 仁志; 北川 善政; 舩橋 誠
北海道歯学雑誌, 38, 2, 152, 157, 北海道歯学会, Mar. 2018
Japanese

Effects of intraperitoneally administered L-histidine on food intake, taste, and visceral sensation in rats
Yuka Okusha; Yoshiyuki Hirai; Hitoshi Maezawa; Kazunari Hisadome; Nobuo Inoue; Yutaka Yamazaki; Makoto Funahashi
JOURNAL OF PHYSIOLOGICAL SCIENCES, 67, 4, 467, 474, Jul. 2017, [Peer-reviewed]
English, Scientific journal

Premotoneuronal inputs to early developing trigeminal motoneurons
Keishi Matsuda; Shiro Nakamura; Mutsumi Nonaka; Ayako Mochizuki; Kiyomi Nakayama; Takehiko Iijima; Atsuro Yokoyama; Makoto Funahashi; Tomio Inoue
Journal of Oral Biosciences, 59, 2, 96, 103, Japanese Association for Oral Biology, 01 May 2017, [Peer-reviewed]
English, Scientific journal

Movement-related cortical magnetic fields associated with self-paced tongue protrusion in humans
Hitoshi Maezawa; Hidetoshi Oguma; Yoshiyuki Hirai; Kazunari Hisadome; Hideaki Shiraishi; Makoto Funahashi
NEUROSCIENCE RESEARCH, 117, 22, 27, Apr. 2017, [Peer-reviewed]
English, Scientific journal

Movement-related cortical magnetic fields associated with self-paced tongue protrusion in humans
Hitoshi Maezawa; Hidetoshi Oguma; Yoshiyuki Hirai; Kazunari Hisadome; Hideaki Shiraishi; Makoto Funahashi
NEUROSCIENCE RESEARCH, 117, 22, 27, Apr. 2017, [Peer-reviewed]
English, Scientific journal

Electrophysiological analysis of neurons in the area postrema.
Funahashi Makoto
Hokkaido J. Dent. Sci., 38, supple, 63, 67, 北海道歯学会, 2017, [Invited]
English, Research institution, This mini-review highlights electrophysiological studies of neurons in the area postrema, including studies using anesthetized animals, neurons in the brain slices, and cultured cells. Electrophysiological studies have demonstrated chemosensitivities, intrinsic membrane properties, synaptic responses and the receptive mechanism of several peptides. For seven decades, electrophysiological research has produced much of what we know about the behavior of postrema neurons. This and other issues are presented and discussed in this paper.

マウス脳幹部におけるGLP-1分泌細胞の電気生理学的特性
久留 和成; 平井 喜幸; 前澤 仁志; 船橋 誠
日本生理学雑誌, 78, 4, 64, 64, (一社)日本生理学会, Jul. 2016
Japanese

Cortico-muscular synchronization by proprioceptive afferents from the tongue muscles during isometric tongue protrusion
Hitoshi Maezawa; Tatsuya Mima; Shogo Yazawa; Masao Matsuhashi; Hideaki Shiraishi; Makoto Funahashi
NEUROIMAGE, 128, 284, 292, Mar. 2016, [Peer-reviewed]
English, Scientific journal

Modulation of stimulus-induced 20-Hz activity for the tongue and hard palate during tongue movement in humans
Hitoshi Maezawa; Kaori Onishi; Kazuyori Yagyu; Hideaki Shiraishi; Yoshiyuki Hirai; Makoto Funahashi
CLINICAL NEUROPHYSIOLOGY, 127, 1, 698, 705, Jan. 2016, [Peer-reviewed]
English, Scientific journal

シスプラチン投与による遅延性悪心誘発に対する脳幹部ドーパミン作動性ニューロンの関与
平井 喜幸; 久留 和成; 前澤 仁志; 舩橋 誠
Journal of Oral Biosciences Supplement, 2015, 439, 439, (一社)歯科基礎医学会, Sep. 2015
Japanese

食欲調節因子に対するマウス脳幹部GLP-1分泌神経細胞の応答特性
久留 和成; 平井 喜幸; 前澤 仁志; 舩橋 誠
Journal of Oral Biosciences Supplement, 2015, 519, 519, (一社)歯科基礎医学会, Sep. 2015
Japanese

Presynaptically mediated effects of cholecystokinin-8 on the excitability of area postrema neurons in rat brain slices.
Shingo Sugeta; Yoshiyuki Hirai; Hitoshi Maezawa; Nobuo Inoue; Yutaka Yamazaki; Makoto Funahashi
Brain research, 1618, 83, 90, 27 Aug. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, Cholecystokinin (CCK) is a well-known gut hormone that shows anorexigenic effects via action at peripheral and central receptors. CCK is also widely distributed throughout the mammalian brain and appears to function as a neurotransmitter and neuromodulator. The area postrema is one of the circumventricular organs, located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. Blood vessels in the area postrema lack a blood brain barrier, offering specific central neural elements unique access to circulating substances. Immunohistochemical studies show CCK-A receptors in the area postrema, and we reported CCK-sensitive area postrema neurons. However, the receptive mechanism of CCK in area postrema neurons still remains unexplained. We investigated the responses of area postrema neurons to agonists and antagonists of CCK receptors using whole cell and perforated patch-clamp recordings in rat brain slices. The application of CCK-8 elicited excitatory responses, such as increases in the frequency of mEPSCs (miniature excitatory postsynaptic currents), a shift toward larger amplitude mEPSCs, and increases in the frequency of action potentials. These changes were found mostly in cells not displaying the hyperpolarization-activated cation current (Ih), except for small excitatory changes in a minority of Ih-positive neurons. Tonic inward currents or an inhibitory response to CCK-8 were never seen. Analysis of the amplitude of mEPSCs before and after the administration of CCK-8 indicated the responses mediated via the presynaptic receptors. The effect of CCK-8 was abolished in the presence of CNQX (AMPA type glutamate receptor antagonist). In the presence of lorglumide (a selective CCK-A receptor antagonist), CCK-8-induced excitatory responses were inhibited. No cells responded to the administration of non-sulfated CCK-8 (CCK-8NS, a selective CCK-B receptor agonist). We conclude that CCK-8 exerts its action via presynaptic CCK-A receptors to facilitate glutamate release onto Ih-negative area postrema cells.

Investigation of neuronal functions in the area postrema : functional differentiation between neurons related to the feeding regulation and neurons triggering nausea and/or emesis
舩橋 誠
北海道歯学雑誌, 36, 1, 24, 26, 北海道歯学会, 2015, [Invited]
Japanese, Scientific journal

Effects of treadmill exercise on the LiCl-induced conditioned taste aversion in rats.
Hisanori Tsuboi; Yoshiyuki Hirai; Hitoshi Maezawa; Kenji Notani; Nobuo Inoue; Makoto Funahashi
Physiology & behavior, 138, 1, 5, Jan. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, Studies have shown that exercise can enhance learning and memory. Conditioned taste aversion (CTA) is an avoidance behavior induced by associative memory of the taste sensation for something pleasant or neutral with a negative visceral reaction caused by the coincident action of a toxic substance that is tasteless or administered systemically. We sought to measure the effects of treadmill exercise on CTA in rats by investigating the effects of exercise on acquisition, extinction and spontaneous recovery of CTA. We made two groups of rats: an exercise group that ran on a treadmill, and a control group that did not have structured exercise periods. To condition rats to disfavor a sweet taste, consumption of a 0.1% saccharin solution in place of drinking water was paired with 0.15M LiCl (2% body weight, i.p.) to induce visceral discomfort. We measured changes of saccharin consumption during acquisition and extinction of CTA. The exercise and no-exercise groups both acquired CTA to similar levels and showed maximum extinction of CTA around 6 days after acquisition. This result indicates that exercise affects neither acquisition nor extinction of CTA. However, in testing for preservation of CTA after much longer extinction periods that included exercise or not during the intervening period, exercising animals showed a significantly lower saccharin intake, irrespective of having exercised or not during the conditioning phase of the trial. This result suggests that exercise may help to preserve aversive memory (taste aversion in this example) as evidence by the significant spontaneous recovery of aversion in exercising animals.

Somatosensory evoked magnetic fields following tongue and hard palate stimulation on the preferred chewing side
Hitoshi Maezawa; Yoshiyuki Hirai; Hideaki Shiraishi; Makoto Funahashi
JOURNAL OF THE NEUROLOGICAL SCIENCES, 347, 1-2, 288, 294, Dec. 2014, [Peer-reviewed]
English, Scientific journal

Contralateral dominance of corticomuscular coherence for both sides of the tongue during human tongue protrusion: An MEG study
Hitoshi Maezawa; Tatsuya Mima; Shogo Yazawa; Masao Matsuhashi; Hideaki Shiraishi; Yoshiyuki Hirai; Makoto Funahashi
NEUROIMAGE, 101, 101C, 245, 255, Nov. 2014, [Peer-reviewed]
English, Scientific journal

L-ヒスチジン誘発の摂食抑制及び悪心誘発に対するノルアドレナリン作動性神経の関与
奥舎 有加; 平井 喜幸; 前澤 仁志; 山崎 裕; 舩橋 誠
Journal of Oral Biosciences Supplement, 2014, 150, 150, (一社)歯科基礎医学会, Sep. 2014
Japanese

最後野および孤束核のノルアドレナリン作動性ニューロンの悪心・嘔吐誘発への関与
平井 喜幸; 前澤 仁志; 舩橋 誠
Journal of Oral Biosciences Supplement, 2014, 206, 206, (一社)歯科基礎医学会, Sep. 2014
Japanese

脳磁図によるヒトの等尺性舌突出時の脳-筋コヒーレンス解析(Corticomuscular syschronization duting isometric tongue protrusion in humans: A magnetoencephalographic study)
前澤 仁志; 美馬 達哉; 白石 秀明; 平井 喜幸; 舩橋 誠
Journal of Oral Biosciences Supplement, 2014, 208, 208, (一社)歯科基礎医学会, Sep. 2014
English

L-ヒスチジン誘発の摂食抑制に伴う脳幹部神経活動の変化
奥舎 有加; 平井 喜幸; 前澤 仁志; 舩橋 誠
日本生理学雑誌, 76, 2, 81, 81, (一社)日本生理学会, Mar. 2014
Japanese

ラット最後野ニューロンのコレシストキニン受容機構
菅田 真吾; 平井 喜幸; 前澤 仁志; 舩橋 誠
日本生理学雑誌, 76, 2, 82, 83, (一社)日本生理学会, Mar. 2014
Japanese

ラット最後野ニューロンのシナプス前CCK受容体を介した興奮性調節
菅田 真吾; 平井 喜幸; 前澤 仁志; 舩橋 誠
Journal of Oral Biosciences Supplement, 2013, 149, 149, (一社)歯科基礎医学会, Sep. 2013
Japanese

Electrophysiologically identified presynaptic mechanisms underlying amylinergic modulation of area postrema neuronal excitability in rat brain slices.
Takeshi Fukuda; Yoshiyuki Hirai; Hitoshi Maezawa; Yoshimasa Kitagawa; Makoto Funahashi
Brain research, 1494, 9, 16, 04 Feb. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal, Amylin, which is co-secreted together with insulin by pancreatic beta cells, is considered to be an important peptide hormone involved in the control of feeding behavior and energy homeostasis. Although the area postrema has been implicated to be a primary target of amylin, there are no studies of the mechanisms by which amylin may alter the excitability of area postrema neurons. To investigate the mechanism for amylinergic modulation of neuronal excitability, we performed perforated patch-clamp recordings from area postrema neurons in rat brainstem slices. Amylin-induced changes in excitatory responses, such as increases in the frequency of mEPSCs (miniature excitatory postsynaptic currents) and changes in the amplitude distribution of mEPSCs, were found in cells not displaying the hyperpolarization-activated cation current (I(h)). Area postrema cells displaying I(h) did not respond to amylin application. Inhibitory responses to amylin were never encountered. Bath application of CNQX (AMPA type glutamate receptor antagonist) abolished the effects of amylin. Depolarization of cells during amylin application was sufficient at 1 μM to cause action potential discharge by responding cells. We conclude that amylin receptors are located mostly on presynaptic glutamatergic terminals connecting to the area postrema neurons not displaying I(h) and amylin concentrations can increase glutamate release enough to cause cell firing. Modulation of amylinergic activity may offer a novel target to influence food intake and obesity.

Hチャネル活性を示す最後野ニューロンの化学受容性と摂食行動調節機序
平井 喜幸; 前澤 仁志; 舩橋 誠
Journal of Oral Biosciences Supplement, 2012, 129, 129, (一社)歯科基礎医学会, Sep. 2012
Japanese

舌と硬口蓋の習慣性咀嚼側刺激により誘発される体性感覚野由来の神経活動 脳磁図を用いた検討
前澤 仁志; 平井 喜幸; 白石 秀明; 舩橋 誠
Journal of Oral Biosciences Supplement, 2012, 133, 133, (一社)歯科基礎医学会, Sep. 2012
Japanese

The role of area postrema neurons expressing H-channels in the induction mechanism of nausea and vomiting
Keisuke Shinpo; Yoshiyuki Hirai; Hitoshi Maezawa; Yasunori Totsuka; Makoto Funahashi
PHYSIOLOGY & BEHAVIOR, 107, 1, 98, 103, Aug. 2012, [Peer-reviewed]
English, Scientific journal

Dental pulp can be a good candidate for nerve grafting in a xeno-graft model
Kazuhiro Matsushita; Wei Wang; Soichiro Itoh; Takanori Domon; Makoto Funahashi; Yasunori Totsuka
JOURNAL OF NEUROSCIENCE METHODS, 205, 2, 246, 251, Apr. 2012, [Peer-reviewed]
English, Scientific journal

強制運動が恐怖条件付けと記憶に及ぼす影響
野島靖子; 八若保孝; 舩橋 誠
北海道歯学雑誌, 33, 1, 10, 16, 2012, [Peer-reviewed]

脳幹スライス標本における中枢ニューロンの生命力に対するポリエチレングリコールの作用
石尾知亮; 平井喜幸; 井上農夫男; 舩橋 誠
北海道歯学雑誌, 31, 1, 25, 34, 2011, [Peer-reviewed]
Japanese

北海道大学全学教育科目「唾液のサイエンス」におけるクリッカー使用とその効果の検討
髙橋 茂; 井上貴一朗; 舩橋 誠; 土門卓文
北海道歯学雑誌, 31, 75, 81, 2011, [Peer-reviewed]
Japanese, Scientific journal

ポリエチレングリコールによる舌下神経核ニューロンの細胞死抑制効果
石尾 知亮; 平井 喜幸; 前澤 仁志; 新保 圭亮; 福田 武志; 井上 農夫男; 舩橋 誠
Journal of Oral Biosciences, 52, Suppl, 132, 132, (一社)歯科基礎医学会, Sep. 2010
Japanese

ZD7288の味覚嫌悪行動への影響
新保 圭亮; 平井 喜幸; 前澤 仁志; 石尾 知亮; 福田 武志; 戸塚 靖則; 舩橋 誠
Journal of Oral Biosciences, 52, Suppl, 146, 146, (一社)歯科基礎医学会, Sep. 2010
Japanese

脳磁図による歯科へのアプローチ
前澤仁志; 舩橋 誠
北海道歯学雑誌, 31, 1, 2, 5, 北海道歯学会, 2010, [Invited]
Japanese, Research institution

唾液中ストレスマーカーの動態分析
児玉高有; 阿部貴恵; 兼平 孝; 森田 学; 舩橋 誠
北海道歯学雑誌, 31, 2, 32, 2010, [Peer-reviewed]

Postnatal development of inhibitory synaptic transmission to superior salivatory neurons in rats
Yoshihiro Mitoh; Makoto Funahashi; Masako Fujita; Motoi Kobashi; Ryuji Matsuo
Journal of Medical Investigation, 56, 1, 270, 272, 2009, [Peer-reviewed]
English, International conference proceedings

Development of inhibitory synaptic transmission to the superior salivatory nucleus in rats
Yoshihiro Mitoh; Makoto Funahashi; Akihito Fujii; Masako Fujita; Motoi Kobashi; Ryuji Matsuo
BRAIN RESEARCH, 1191, 47, 54, Jan. 2008, [Peer-reviewed]
English, Scientific journal

Purinergic modulation of area postrema neuronal excitability in rat brain slices
Naoki Kodama; Makoto Funahashi; Yoshihiro Mitoh; Shogo Minagi; Ryuji Matsuo
BRAIN RESEARCH, 1165, 50, 59, Aug. 2007, [Peer-reviewed]
English, Scientific journal

ラット脳スライス標本における延髄最後野ニューロンのセビメリンによる興奮性応答
兒玉 直紀; 舩橋 誠; 美藤 純弘; 松尾 龍二
Journal of Oral Biosciences, 49, Suppl., 119, 119, (一社)歯科基礎医学会, Aug. 2007
Japanese

ラット孤束膠様核ニューロンのニコチン感受性
舩橋 誠; 兒玉 直紀; 美藤 純弘; 松尾 龍二; 赤池 忠
日本生理学雑誌, 69, 6, 241, 241, (一社)日本生理学会, Jun. 2007
Japanese

プリン作動性受容体を介するラット最後野ニューロン活動の修飾
兒玉 直紀; 舩橋 誠; 美藤 純弘; 松尾 龍二
Journal of Oral Biosciences, 48, Suppl., 132, 132, (一社)歯科基礎医学会, Sep. 2006
Japanese

最後野内ニコチン局所投与により誘発される孤束膠様核ニューロンの興奮性応答
舩橋 誠; 兒玉 直紀; 美藤 純弘; 松尾 龍二; 赤池 忠
Journal of Oral Biosciences, 48, Suppl., 188, 188, (一社)歯科基礎医学会, Sep. 2006
Japanese

ラット上唾液核に対する上位脳からの興奮性入力に関する電気生理学的検討
美藤 純弘; 藤井 昭仁; 舩橋 誠; 小橋 基; 松尾 龍二
Journal of Oral Biosciences, 48, Suppl., 176, 176, (一社)歯科基礎医学会, Sep. 2006
Japanese

Variety of morphological and electrophysiological properties of area postrema neurons in adult rat brain slices
M Funahashi; Y Mitoh; T Akaike; R Matsuo
NEUROSCIENCE RESEARCH, 54, 1, 43, 48, Jan. 2006, [Peer-reviewed]
English, Scientific journal

Peripheral N-methyl-D-aspartate receptors modulate nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits
A Kohjitani; M Funahashi; T Miyawaki; M Hanazaki; R Matsuo; M Shimada
ANESTHESIA AND ANALGESIA, 101, 6, 1681, 1688, Dec. 2005, [Peer-reviewed]
English, Scientific journal

ラット最後野ニューロンの機能と形態
舩橋 誠; 美藤 純弘; 兒玉 直紀; 松尾 龍二; 赤池 忠
日本生理学雑誌, 67, 12, 400, 400, (一社)日本生理学会, Dec. 2005
Japanese

The origin of sensory nerve fibers that innervate the submandibular salivary gland in the rat
M Kobashi; H Ichikawa; M Kobashi; M Funahashi; Y Mitoh; R Matsuo
BRAIN RESEARCH, 1060, 1-2, 184, 187, Oct. 2005, [Peer-reviewed]
English, Scientific journal

最後野におけるプリン受容体(P2X)による神経活動の修飾
兒玉 直紀; 舩橋 誠; 美藤 純弘; 松尾 龍二
Journal of Oral Biosciences, 47, Suppl., 113, 113, (一社)歯科基礎医学会, Sep. 2005
Japanese

孤束膠様核単一ニューロンの形態的特徴,膜特性および化学感受性
舩橋 誠; 美藤 純弘; 兒玉 直紀; 松尾 龍二; 赤池 忠
Journal of Oral Biosciences, 47, Suppl., 175, 175, (一社)歯科基礎医学会, Sep. 2005
Japanese

舌および顎下腺・舌下腺を支配するラット上唾液核細胞における抑制性シナプス伝達の生後発達
美藤 純弘; 舩橋 誠; 藤井 昭仁; 小橋 基; 松尾 龍二
Journal of Oral Biosciences, 47, Suppl., 179, 179, (一社)歯科基礎医学会, Sep. 2005
Japanese

ラット顎下腺に分布する感覚神経の入力経路に関する組織化学的研究
小橋 美由紀; 小橋 基; 舩橋 誠; 美藤 純弘; 松尾 龍二
岡山歯学会雑誌, 24, 1, 16, 17, 岡山歯学会, Jun. 2005
Japanese

Activation of presynaptic 5-HT3 receptors facilities glutamatergic synaptic inputs to area postrema neurons in rat brain slices
M Funahashi; Y Mitoh; R Matsuo
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 26, 8, 615, 622, Oct. 2004, [Peer-reviewed]
English, Scientific journal

ラット顎下腺に分布する感覚神経の経路に関する組織化学的研究
小橋 美由紀; 舩橋 誠; 美藤 純弘; 小橋 基; 松尾 龍二
Journal of Oral Biosciences, 46, 5, 410, 410, (一社)歯科基礎医学会, Sep. 2004
Japanese

ラット上唾液核細胞のシナプス入力の経路に関する電気生理学的解析
藤井 昭仁; 美藤 純弘; 船橋 誠; 小橋 基; 山本 照子; 松尾 龍二
Journal of Oral Biosciences, 46, 5, 410, 410, (一社)歯科基礎医学会, Sep. 2004
Japanese

ラット顎下腺からの求心性情報の電気生理学的解析
古谷 裕資; 舩橋 誠; 美藤 純弘; 小橋 基; 松尾 龍二
Journal of Oral Biosciences, 46, 5, 433, 433, (一社)歯科基礎医学会, Sep. 2004
Japanese

ラット上唾液核細胞における興奮性の反復シナプス入力に対する発火特性
美藤 純弘; 舩橋 誠; 藤井 昭仁; 小橋 基; 松尾 龍二
Journal of Oral Biosciences, 46, 5, 433, 433, (一社)歯科基礎医学会, Sep. 2004
Japanese

Nicotinic modulation of area postrema neuronal excitability in rat brain slices
M Funahashi; Y Mitoh; R Matsuo
BRAIN RESEARCH, 1017, 1-2, 227, 233, Aug. 2004, [Peer-reviewed]
English, Scientific journal

The sensitivity of hyperpolarization-activated cation current (I-h) to propofol in rat area postrerna neurons
M Funahashi; Y Mitoh; R Matsuo
BRAIN RESEARCH, 1015, 1-2, 198, 201, Jul. 2004, [Peer-reviewed]
English, Scientific journal

Excitatory and inhibitory postsynaptic currents of the superior salivatory nucleus innervating the salivary glands and tongue in the rat
Y Mitoh; M Funahashi; M Kobashi; R Matsuo
BRAIN RESEARCH, 999, 1, 62, 72, Feb. 2004, [Peer-reviewed]
English, Scientific journal

Role of the hyperpolarization-activated cation current (I-h) in pacemaker activity in area postrema neurons of rat brain slices
M Funahashi; Y Mitoh; A Kohjitani; R Matsuo
JOURNAL OF PHYSIOLOGY-LONDON, 552, 1, 135, 148, Oct. 2003, [Peer-reviewed]
English, Scientific journal

Suppression of the hyperpolarization-activated inward current contributes to the inhibitory actions of propofol on rat CA1 and CA3 pyramidal neurons
H Higuchi; M Funahashi; T Miyawaki; Y Mitoh; A Kohjitani; M Shimada; R Matsuo
NEUROSCIENCE RESEARCH, 45, 4, 459, 472, Apr. 2003, [Peer-reviewed]
English, Scientific journal

Mexiletine inhibits nonadrenergic noncholinergic lower oesophageal sphincter relaxation in rabbits
A Kohjitani; T Miyawaki; M Funahashi; Y Mitoh; R Matsuo; M Shimada
EUROPEAN JOURNAL OF PHARMACOLOGY, 465, 1-2, 145, 151, Mar. 2003, [Peer-reviewed]
English, Scientific journal

Ketamine and midazolam differentially inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits - Role of superoxide anion and nitric oxide synthase
A Kohjitani; T Miyawaki; M Funahashi; H Higuchi; R Matsuo; M Shimada
ANESTHESIOLOGY, 98, 2, 449, 458, Feb. 2003, [Peer-reviewed]
English, Scientific journal

Morphological study on the superior salivatory nucleus innervating the submandibular and sublingual salivatory glands and tongue in rats.
Matsuo R; Mitoh Y; Funahashi M; Kobashi M
Dentistry in Japan, 39, 34, 36, 2003

プロポフォールの中枢神経抑制作用に関する電気生理学的研究
樋口仁; 舩橋 誠; 宮脇卓也; 美藤純弘; 糀谷 淳; 嶋田昌彦; 松尾龍二
岡山歯学会雑誌, 22, 1, 165, 176, 岡山歯学会, 2003, [Peer-reviewed]
Japanese, ラットの新鮮脳海馬スライスにGABA A受容体拮抗薬ピクロトキシンを投与しててんかん様の自然発火を惹起させ,これにプロポフォールを投与したところ,濃度依存的に自然発火の頻度,持続時間が減少した.又,Schaffer側枝の電気刺激で惹起したてんかん様バースト発火に対しても,プロポフォールは濃度依存的に持続時間を減少させた.更にピクロトキシン及びAMPA型グルタミン酸受容体拮抗薬CNQX存在下でSchaffer側枝の電気刺激により誘発した興奮性シナプス後電位に対し,プロポフォール投与で振幅,持続時間は減少した.ピクロトキシン及びNMDA型グルタミン酸受容体拮抗薬CPP存在下での誘発電位に対してもプロポフォール投与は電位の持続時間を減少させた.次に細胞内パルス通電により生ずる海馬CA1ニューロンの膜電位変化に対し,プロポフォールを投与したところ,これらの膜電位変化は著明に減少した.プロポフォールが過分極作動性内向き電流(H電流)を抑制し,膜電位の過分極,膜抵抗の増加を引き起こすことが示された

ラット上唾液核細胞における抑制性シナプス伝達はGABAB受容体を介するシナプス前抑制を受けている
美藤 純弘; 船橋 誠; 小橋 基; 松尾 龍二
歯科基礎医学会雑誌, 44, 5, 488, 488, (一社)歯科基礎医学会, Sep. 2002
Japanese

Electrophysiological properties of the rat area postrema neurons displaying both the transient outward current and the hyperpolarization-activated inward current
M Funahashi; Y Mitoh; R Matsuo
BRAIN RESEARCH BULLETIN, 58, 3, 337, 343, Jul. 2002, [Peer-reviewed]
English, Scientific journal

Two distinct types of transient outward currents in area postrema neurons in rat brain slices
M Funahashi; Y Mitoh; R Matsuo
BRAIN RESEARCH, 942, 1-2, 31, 45, Jun. 2002, [Peer-reviewed]
English, Scientific journal

Modulation of Neural Activity in the Lateral Nucleus of the Amygdala by the Propagation of Synchronous Burst Discharges from Parahippocampal Neurons
Funahashi Makoto
Japanese journal of oral biology, 44, 3, 195, 202, Japanese Association for Oral Biology, 2002, [Peer-reviewed]
Japanese

Long-term enhancement of excitatory synaptic inputs to layer V parahippocampal neurons by low frequency stimulation in rat brain slices
M Funahashi; R Matsuo; M Stewart
NEUROSCIENCE RESEARCH, 42, 1, 65, 77, Jan. 2002, [Peer-reviewed]
English, Scientific journal

Propofol suppresses a hyperpolarization-activated inward current in rat hippocampal CA1 neurons
M Funahashi; H Higuchi; T Miyawaki; M Shimada; R Matsuo
NEUROSCIENCE LETTERS, 311, 3, 177, 180, Oct. 2001, [Peer-reviewed]
English, Scientific journal

Intravenous anesthetics inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation via nitric oxide-cyclic guanosine monophosphate pathway modulation in rabbits
A Kohjitani; T Miyawaki; M Funahashi; Y Mitoh; R Matsuo; M Shimada
ANESTHESIOLOGY, 95, 1, 176, 183, Jul. 2001
English, Scientific journal

Role of parabrachial nucleus in submandibular salivary secretion induced by bitter taste stimulation in rats
R Matsuo; Y Yamauchi; M Kobashi; M Funahashi; Y Mitoh; A Adachi
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 88, 1-2, 61, 73, Apr. 2001, [Peer-reviewed]
English, Scientific journal

Propagation of synchronous burst discharges from entorhinal cortex to morphologically and electrophysiologically identified neurons of rat lateral amygdala
M Funahashi; R Matsuo; M Stewart
BRAIN RESEARCH, 884, 1-2, 104, 115, Nov. 2000, [Peer-reviewed]
English, Scientific journal

舌,顎下腺・舌下腺を支配するラット上唾液核細胞のシナプス入力の解析
美藤 純弘; 船橋 誠; 小橋 基; 松尾 龍二
歯科基礎医学会雑誌, 42, 5抄録集, 472, 472, (一社)歯科基礎医学会, Aug. 2000
Japanese

Activity of neurons in the nucleus of the solitary tract of rats: effect of osmotic and mechanical stimuli
S Izawa; K Inoue; A Adachi; M Funahashi
NEUROSCIENCE LETTERS, 288, 1, 33, 36, Jul. 2000, [Peer-reviewed]
English, Scientific journal

舌,顎下腺・舌下腺を支配する上唾液核細胞の形態学的特徴と膜特性
美藤 純弘; 船橋 誠; 小橋 基; 松尾 龍二
岡山歯学会雑誌, 19, 1, 204, 204, 岡山歯学会, Jun. 2000
Japanese

Re-entrant activity in a presubiculum-subiculum circuit generates epileptiform activity in vitro
M Funahashi; E Harris; M Stewart
BRAIN RESEARCH, 849, 1-2, 139, 146, Dec. 1999, [Peer-reviewed]
English, Scientific journal

Noxious tooth pulp stimulation suppresses c-fos expression in the rat hippocampal formation
M Funahashi; YF He; T Sugimoto; R Matsuo
BRAIN RESEARCH, 827, 1-2, 215, 220, May 1999, [Peer-reviewed]
English, Scientific journal

Properties of gamma-frequency oscillations initiated by propagating population bursts in retrohippocampal regions of rat brain slices
M Funahashi; M Stewart
JOURNAL OF PHYSIOLOGY-LONDON, 510, 1, 191, 208, Jul. 1998, [Peer-reviewed]
English, Scientific journal

Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation
T Sugimoto; YF He; M Funahashi; H Ichikawa
BRAIN RESEARCH, 794, 2, 353, 358, Jun. 1998, [Peer-reviewed]
English, Scientific journal

GABA receptor-mediated post-synaptic potentials in the retrohippocampal cortices: regional, laminar and cellular comparisons
M Funahashi; M Stewart
BRAIN RESEARCH, 787, 1, 19, 33, Mar. 1998, [Peer-reviewed]
English, Scientific journal

Presubicular and parasubicular cortical neurons of the rat: Functional separation of deep and superficial neurons in vitro
M Funahashi; M Stewart
JOURNAL OF PHYSIOLOGY-LONDON, 501, 2, 387, 403, Jun. 1997, [Peer-reviewed]
English, Scientific journal

Exaggerated C-fiber activation prevents peripheral nerve injury-induced hyperinducibility of c-Fos in partially deafferented spinal dorsal horn
T Sugimoto; M Funahashi; C Xiao; A Adachi; H Ichikawa
NEUROSCIENCE RESEARCH, 27, 2, 161, 167, Feb. 1997, [Peer-reviewed]
English, Scientific journal

Glucose sensors in the medulla oblongata
A. Adachi; M. Kobashi; M. Funahashi
Japanese Journal of Physiology, 47, 1, S37, S38, 1997, [Peer-reviewed]
English, International conference proceedings

Presubicular and parasubicular cortical neurons of the rat: Electrophysiological and morphological properties
M Funahashi; M Stewart
HIPPOCAMPUS, 7, 2, 117, 129, 1997, [Peer-reviewed]
English, Scientific journal

Glucose-responsive neurons in the brainstem
A Adachi; M Kobashi; M Funahashi
OBESITY RESEARCH, 3, S735, S740, Dec. 1995
English, Scientific journal

ラット最後野中のグルコース応答性ニューロンに関する電気生理学的研究
船橋誠; 足立明
第13回日本肥満学会記録, 127, 129, 1993
Japanese, Research society

GLUCOSE-RESPONSIVE NEURONS EXIST WITHIN THE AREA POSTREMA OF THE RAT - IN-VITRO STUDY ON THE ISOLATED SLICE PREPARATION
M FUNAHASHI; A ADACHI
BRAIN RESEARCH BULLETIN, 32, 5, 531, 535, 1993, [Peer-reviewed]
English, Scientific journal

HEPATIC THERMOGENESIS RELATION TO FOOD-INTAKE IN THE CONSCIOUS RAT
A ADACHI; M FUNAHASHI; J OHGA
BRAIN RESEARCH BULLETIN, 27, 3-4, 529, 533, Sep. 1991, [Peer-reviewed]
English, Scientific journal

POSSIBLE ROLE OF THE AREA POSTREMA IN THE CONTROL OF INGESTION
A ADACHI; M FUNAHASHI; M KOBASHI; M AOYAMA
PROGRESS IN OBESITY RESEARCH 1990, 37, 39, 1991
English, International conference proceedings

摂食に伴う肝温変化に対する腹部迷走神経切断の影響
足立明; 研山知子; 船橋誠
第10回日本肥満学会記録, 109, 110, 1990
Japanese, Research society

エメチン誘発の悪心に対する迷走神経切除と最後野損傷の影響
舩橋誠; 平井喜幸; 藤田麻由; 久留和成; 前澤仁志, Journal of Oral Biosciences Supplement (Web), 2018, 2018

トレッドミル歩行時の歩行リズムに対する咀嚼リズムの引き込み現象
前澤 仁志; 小金丸 聡子; 松橋 眞生; 舩橋 誠; 美馬 達哉, 臨床神経生理学, 45, 5, 434, 434, Oct. 2017
(一社)日本臨床神経生理学会, Japanese

ヒトの舌突出時の舌に関する舌筋電図コヒーレンスの対側優位性 MEG study(Contralateral dominance of corticomuscular coherence for the tongue during human tongue protrusion: An MEG study)
前澤 仁志; 美馬 達哉; 矢澤 省吾; 松橋 眞生; 白石 秀明; 舩橋 誠, 臨床神経生理学, 42, 5, 298, 298, Oct. 2014
(一社)日本臨床神経生理学会, Japanese

L-ヒスチジン誘発の摂食抑制及び悪心誘発に対するノルアドレナリン作動性神経の関与
奥舎有加; 奥舎有加; 平井喜幸; 前澤仁志; 山崎裕; 舩橋誠, Journal of Oral Biosciences Supplement (Web), 2014, 2014

最後野および孤束核のノルアドレナリン作動性ニューロンの悪心・嘔吐誘発への関与
平井喜幸; 前澤仁志; 舩橋誠, Journal of Oral Biosciences Supplement (Web), 2014, 2014

体性感覚誘発脳磁場による口唇感覚異常の客観的評価
前澤 仁志; 吉田 和也; 美馬 達哉; 平井 喜幸; 舩橋 誠; 長峯 隆; 福山 秀直, Journal of Oral Biosciences Supplement, 2013, 181, 181, Sep. 2013
(一社)歯科基礎医学会, Japanese

前シナプス部アミリン受容体を介した最後野ニューロンの活動制御
福田武志; 舩橋誠; 北川善政, 日本口腔科学会雑誌, 62, 1, 78, 79, 10 Jan. 2013
(NPO)日本口腔科学会, Japanese

Possible roles of area postrema neurons expressing H-channels in the induction of nausea and vomiting
Yoshiyuki Hirai; Hitoshi Maezawa; Makoto Funahashi, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S259, S259, 2013
English, Summary international conference

Neural activity in the somatosensory cortex following oral stimulation applied to preferred chewing side : An MEG study
Hitoshi Maezawa; Yoshiyuki Hirai; Makoto Funahashi, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S208, S208, 2013
English, Summary international conference

ラット延髄最後野におけるアミリンによるシナプス伝達の修飾
福田武志; 北川善政; 舩橋誠, 日本口腔科学会雑誌, 61, 1, 176, 176, 10 Jan. 2012
(NPO)日本口腔科学会, Japanese

Hチャネル活性を示す最後野ニューロンの化学受容性と摂食行動調節機序
平井喜幸; 前澤仁志; 舩橋誠, Journal of Oral Biosciences Supplement (Web), 2012, 2012

ラット延髄最後野におけるアミリン応答性ニューロンに関する電気生理学的解析
福田武志; 平井喜幸; 前澤仁志; 新保圭亮; 石尾知亮; 北川善政; 舩橋誠, J Oral Biosci, 52, Supplement, 131, 131, 10 Sep. 2010
(一社)歯科基礎医学会, Japanese

Analysis of the fluctuation of stress markers in saliva
Hokkaido Journal of dental science, 31, 2, 32, 2010

Postnatal development of inhibitory synaptic transmission to superior salivatory neurons in rats
Yoshihiro Mitoh; Makoto Funahashi; Masako Fujita; Motoi Kobashi; Ryuji Matsuo, Journal of Medical Investigation, 56, 1, 270, 272, 2009
English

前シナプスセロトニン受容体を介するグルタミン酸作動性シナプスの変調
舩橋 誠; 松尾龍二, 生体の科学, 59, 1, 59, 65, 2008

Purinergic modulation of area postrema neuronal excitability in rat brain slices
Naoki Kodama; Makoto Funahashi; Yoshihiro Mitoh; Shogo Minagi; Ryuji Matsuo, BRAIN RESEARCH, 1165, 50, 59, Aug. 2007
English

文献と臨床の橋わたし 文献からみる歯科治療時の嘔吐に対するアプローチ
兒玉 直紀; 舩橋 誠; 皆木 省吾, 日本歯科評論, 67, 1, 182, 184, Jan. 2007
(株)ヒョーロン・パブリッシャーズ, Japanese

最後野ニューロンにおける過分極作動性カチオン電流(Ih)のプロポフォールに対する感受性
舩橋 誠; 美藤 純弘; 松尾 龍二, Journal of oral biosciences, 46, 5, 394, 394, 01 Sep. 2004
歯科基礎医学会, Japanese

最高野ニューロンのぺースメーカー活性/過分極作動性内向きカチオン電流による調節.
舩橋 誠; 松尾龍二, 生体の科学, 55, 6, 627, 633, 2004
金原一郎記念医学医療振興財団, Japanese

過分極作動性内向き電流(Ih)によるラット最後野神経活動の制御機構
舩橋 誠; 美藤 純弘; 樋口 仁; 松尾 龍二, 歯科基礎医学会雑誌, 44, 5, 412, 412, 20 Sep. 2002
歯科基礎医学会, Japanese

Modulation of neural activity in the lateral nucleus of the amygdala by the propagation of synchronous burst discharges from parahippocampal neurons.
44, 195, 202, 2002

海馬CA1ニューロンのH電流に対するプロポフォールの抑制作用
樋口 仁; 舩橋 誠; 美藤 純弘; 嶋田 昌彦; 松尾 龍二, 歯科基礎医学会雑誌, 43, 5, 600, 600, 20 Aug. 2001
歯科基礎医学会, Japanese

スライスパッチクランプ法によるラット最後野ニューロンの膜特性解析
舩橋 誠; 美藤 純弘; 松尾 龍二, 歯科基礎医学会雑誌, 43, 5, 599, 599, 20 Aug. 2001
歯科基礎医学会, Japanese

内嗅野から扁桃体外側核ニューロンへの同期性バースト発火の伝播
舩橋 誠, 歯科基礎医学会雑誌, 43, 5, 528, 528, 20 Aug. 2001
歯科基礎医学会, Japanese

海馬体ニューロンのバースト発火に誘発されるシナプス伝達の長期増強
舩橋 誠; 美藤 純弘; 松尾 龍二, 歯科基礎医学会雑誌, 42, 5, 433, 433, 30 Aug. 2000
歯科基礎医学会, Japanese

てんかん様バースト発火に対するプロポフォールの抑制機序の検討
樋口 仁; 舩橋 誠; 美藤 純弘; 嶋田 昌彦; 松尾 龍二, 歯科基礎医学会雑誌, 42, 5, 471, 471, 30 Aug. 2000
歯科基礎医学会, Japanese

海馬体および扁桃体ニューロンの膜特性および神経連絡網
舩橋 誠; 美藤 純弘; 松尾 龍二, 歯科基礎医学会雑誌, 41, 5, 409, 409, 20 Aug. 1999
歯科基礎医学会, Japanese

舌と顎下腺・舌下腺を支配するラット上唾液核細胞の形態学的特徴
美藤 純弘; 小橋 基; 船橋 誠; 松尾 龍二, 歯科基礎医学会雑誌, 41, 5, 498, 498, 20 Aug. 1999
歯科基礎医学会, Japanese

歯科生理学実習
岩田, 幸一; 井上, 富雄(口腔科学); 舩橋, 誠; 加藤, 隆史(歯学); 重村, 憲徳; 篠田, 雅路; 小野, 堅太郎; 上阪, 直史; 奥村, 敏; 澁川, 義幸; 北川, 純一; 石井, 久淑; 吉垣, 純子; 合田, 征司; 増田, 裕次; 村本, 和世; 佐藤, 義英; 山村, 健介; 齋藤充
医歯薬出版, Mar. 2022, 9784263458693, viii, 129p, Japanese

基礎歯科生理学第7版
舩橋, 誠, 第3章「体液」，第23章「嘔吐」
医歯薬出版, Mar. 2020, 9784263458464, xxiv, 475p, Japanese, [Contributor]

基礎歯科生理学第7版
岩田, 幸一; 井上, 富雄(口腔科学); 舩橋, 誠; 加藤, 隆史(歯学)
医歯薬出版, Mar. 2020, 9784263458464, xxiv, 475p, Japanese, [Editor]

歯・口腔の構造と機能 口腔解剖学・口腔組織発生学，口腔生理学
医歯薬出版, 2011

人体の構造と機能
医歯薬出版, 2010

基礎歯科生理学 第5版
医歯薬出版, 2008

過分極作動性チャネルの中枢神経系における活性と生体制御機能の解析
舩橋, 誠
[北海道大学大学院歯学研究科], May 2007, 1冊

口腔生物学と医学, 2024年, 博士後期課程, 歯学院

咬合咀嚼生理学研究, 2024年, 博士後期課程, 歯学院

摂食行動制御学研究, 2024年, 博士後期課程, 歯学院

発表・論文執筆法演習Ⅰ, 2024年, 博士後期課程, 歯学院

発表・論文執筆法演習Ⅱ, 2024年, 博士後期課程, 歯学院

発表・論文執筆法演習Ⅲ, 2024年, 博士後期課程, 歯学院

頭顎口定位制御学, 2024年, 博士後期課程, 歯学院

頭顎口定位制御学, 2024年, 博士後期課程, 歯学院

頭顎口定位制御学研究, 2024年, 博士後期課程, 歯学院

生理学的解析技法, 2024年, 博士後期課程, 歯学院

歯学研究概論, 2024年, 博士後期課程, 歯学院

基本技法, 2024年, 博士後期課程, 歯学院

関連臨床医学, 2024年, 学士課程, 歯学部

アクティブラーニング科目Ⅰ, 2024年, 学士課程, 歯学部

生理学・口腔生理学Ⅰ, 2024年, 学士課程, 歯学部

生理学・口腔生理学Ⅱ, 2024年, 学士課程, 歯学部

生理学・口腔生理学実習, 2024年, 学士課程, 歯学部

健康と社会, 2024年, 学士課程, 全学教育

健康と社会, 2024年, 学士課程, 全学教育

2005 - Present
日本生理学会北海道地方会

Elucidation of the mechanism of updating the conditioned memory acquired by nausea and vomiting and development of a novel nausea suppression method.
Grants-in-Aid for Scientific Research
01 Apr. 2025 - 31 Mar. 2028
舩橋 誠; 乾 賢; 吉澤 知彦
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 25K12947

Neurophysiological study for the elucidation of the difference of the central mechanism of nausea and vomiting and the development of the nausea suppression therapy.
Grants-in-Aid for Scientific Research
01 Apr. 2022 - 31 Mar. 2025
舩橋 誠
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 22K09900

Study of the mechanism of action of lipid rafts on general anesthetics by bioimaging and electrophysiological techniques.
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Apr. 2022 - Mar. 2025
長谷 由理; 舩橋 誠; 長谷部 晃
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 22K09062

Neurophysiological study of central mechanisms for nausea and vomiting to create a new antiemetic therapy.
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Apr. 2019 - Mar. 2022
舩橋 誠; 久留 和成; 平井 喜幸
2019年度の研究実績の概要について，実施した研究計画，結果，考察，新たな問題点について下記に述べる．
ラットを用いた実験において甘味摂取直後に催吐物質を腹腔内注射すると，甘味（条件刺激）と悪心（無条件刺激）との連合学習が成立して甘味摂取を忌避するようになる．これを条件付け味覚嫌悪（CTA：conditioned taste aversion）と呼び，本研究ではこれを薬物投与による悪心誘発の指標として用いた．催吐性のある薬物としてシスプラチン（抗がん剤），エメチン（吐根の成分），トラネキサム酸を比較した．こららの薬物をコントロール群のラットに投与すると，著明なCTAの獲得を認めた．実験群として最後野切除群，迷走神経求心路切除群，最後野と迷走神経求心路の両方切除群を作成し，シスプラチン，エメチン，トラネキサム酸の腹腔投与を無条件刺激にした場合のCAT獲得を調べたところ，迷走神経求心路切除群はエメチン投与によってCTAを獲得したが，最後野切除群においてはエメチン投与によるCTA獲得は抑制された．この結果はエメチン誘発の悪心が最後野を介して惹起されることを示唆するものであった．シスプラチンについては，最後野切除群，迷走神経求心路切除群，最後野と迷走神経求心路の両方切除群のいずれにおいてもCTAの獲得を認めたため，エメチンとは異なり迷走神経や最後野を介さない経路が悪心誘発に関与していることが示唆された．また，トラネキサム酸の腹腔投与による悪心誘発は迷走神経求心路切除群で条件付けテスト日2日目におけるCTA獲得が抑制され，最後野切除群においては条件付けテスト日1日目からCTA獲得が強く抑制されたことから，迷走神経求心路と最後野の両方を介して悪心が誘発されていることが示唆された．橋と延髄より上位脳における悪心誘発機序を考慮することが全貌解明に必要であると考えられた．
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, 19K10039

Study of neuronal activity, a molecular basis and a behavioral change related to chemoreceptor-mediated nausea and emesis.
Grants-in-Aid for Scientific Research
01 Apr. 2016 - 31 Mar. 2019
FUNAHASHI MAKOTO
As an intracellular mechanism for glucose responsiveness of the area postrema neurons, it was found that the ATP-dependent potassium channel (KATP channel) was closed by an increase in the extracellular glucose concentration, leading to the generation of depolarization and action-potentials. The glucose-responsive neurons were suggested to be H-channel non-expressing cells. The neuronal activity of the area postrema is crucial for the inducing mechanism of emetine-induced nausea, and it was also found that depolarization occurs in the central neurons including the nucleus tractus solitarius, the central nucleus of amygdala, the bed nucleus. It became clear that the memory recall of the taste aversion did not involve the activity of the nervous system related to a nausea induction.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 16K11471

Analysis of hunger and satiety signalling pathway from peripheral to central nervous system using visualizing technology of a marker of neuronal activation
Grants-in-Aid for Scientific Research
01 Apr. 2016 - 31 Mar. 2019
Hisadome Kazunari
Glucagon-like peptide-1 (GLP-1) is released postprandially from the gut and known as a satiety peptide. However, it’s unclear whether peripheral GLP-1 can directly reach receptors in the brain. To examine how peripheral GLP-1 reaches into the brain, we analyzed the c-Fos, a marker of neuronal activation, expression in the brainstem neurons after intraportal injection of GLP-1. Physiological concentration of GLP-1 induced c-Fos expression of nucleus tract solitarius neurons, but not of area postrema neurons. These results suggest the GLP-1 secreted from the gut might reach the brain as a signal via vagal nerve rather than as a hormone via the bloodstream. These experiments were used transgenic rat expressing green fluorescent protein (GFP) under control of a c-fos promoter. Therefore, c-Fos-expressing neurons were identifiable by GFP. This experimental design might be applicable to the identification of secondary neurons for satiety- or hunger-signal of peripheral peptides.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 16K08516

嘔吐誘発と摂食調節に関わる延髄最後野ニューロンの機能分化とその分子基盤の解明
学術研究助成基金助成金（基盤研究（C））
Apr. 2015 - Mar. 2018
舩橋 誠
文部科学省, Principal investigator, Competitive research funding

Identification of emesis-inducing medullary neurons and anslysis of their functions.
Grants-in-Aid for Scientific Research
2010 - 2012
FUNAHASHI Makoto; HIRAI Yoshiyuki; MAEZAWA Hitoshi
We investigated how neurons in the area postrema known as a chemoreceptor trigger zone are related to the induction of nausea and/or emesis and to the control of food intake. We found that the neurons expressing H channels are closely related to the induction of nausea but they do not respond to amylin that is known as a satiety peptide. Responses to amylin were found only in the neurons not expressing H channels. We concluded that these date suggested the presence of functional differentiation between the neurons expressing H channels and the neurons not expressing H channels.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, Competitive research funding, 22592057

Mechanisms of salivary gland atrophy induced by soft food
Grants-in-Aid for Scientific Research
2009 - 2012
TAKAHASHI Shigeru; WAKITA Minoru; YAMAMOTO Tsuneyuki; FUNAHASHI Makoto; IIZUKA Tadashi; YOSHIMURA Yoshitaka
Salivary glands of rats fed a liquid diet for 3 weeks were investigated microscopically to clarify the effects of soft food on salivary glands. Parotid glands of experimental rats became atrophic after liquid diet feeding, and cell shrinkage, cell death, and reduction of speed of cell-cycle were identified in the atrophic parotid glands. However, such atrophic alterations were not observed in submandibular and sublingual glands following liquid diet feeding. These observations suggest that it depends on the kind of salivary glands whether liquid diet feeding induces atrophy to the salivary glands.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, Coinvestigator not use grants, Competitive research funding, 21390499

The effect of intraoperative hypotension on postoperative nausea and vomiting
Grants-in-Aid for Scientific Research
2009 - 2011
KUROZUMI Akihiro; FUNAHASHI Makoto; KAMEKURA Nobuhito; FUKUSHIMA Kazuaki
Postoperative nausea and vomiting is one of the most common complications, but its mechanism is unknown. In the present study, we studied the c-Fos expression in the area postrema for the purpose of investigating whether intraoperative hypotension causes postoperative nausea and vomiting. Hypotension significantly increased c-Fos expression in the area postrema of the rats received isoflurane or propofol anesthesia. Although we could not confirm the evidence by behavioral experiments, it is possible that nervous excitement in the area postrema by intraoperative hypotension causes nausea and vomiting.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Coinvestigator not use grants, Competitive research funding, 21592567

Analysis of the functional and biological roles of the hyperpolarization-activated cation current in the central nervous system,
Grants-in-Aid for Scientific Research(基盤研究(C))
2005 - 2006
Makoto FUNAHASHI; 十川 千春; 美藤 純弘; 十川 紀夫; 松尾 龍二
We performed whole-cell patch-clamp recordings from area postrema neurons to investigate the functional and biological roles of the hyperpolarization-activated cation current (Ih).1) Morphological propertiesUsing electrophysiological criteria, AP neurons were subdivided into three groups : 1) cells displaying both the hyperpolarization-activated cation current (I_h) and the fast transient outward current (fast I_) ; 2) cells displaying only the fast I_ ; and 3) cells displaying only the slow Ito. All AP neurons had a single axon that was distinctly thinner than the cells' dendrites....
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(C), 岡山大学->北海道大学, Principal investigator, Competitive research funding, 17591937

Electrophysiological study on development of inhibitory synaptic transmission in central neurons involved in oral function.
Grants-in-Aid for Scientific Research(基盤研究(C))
2005 - 2006
Yoshihiro MITOH; 松尾 龍二; 舩橋 誠
We showed the excitatory (glutamate) and inhibitory (GABA and glycine) synaptic inputs to superior salivatory (SS) neurons in neonatal rat brainstem slices. There is a possibility that the synaptic transmission to SS neurons develop postnatally with the development of oral function. In the present study, we studied the development of the inhibitory synaptic transmission to SS neurons electrophysiologically. We used Wistar rats at postnatal day 2 (P2) to P14. The SS neurons innervating the submandibular salivary glands and tongue were labeled by retrograde axonal transport of a fluorescent d...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(C), 岡山大学, Coinvestigator not use grants, Competitive research funding, 17591935

Analysis of the functional role of the hyperpolarization-activated cation cunert within the centaral nervous system.
Grants-in-Aid for Scientific Research(基盤研究(C))
2003 - 2004
Makoto FUNAHASHI; 松雄 龍二; 美藤 純弘; 十川 千春
This study elucidated the membrane properties, morphology and chemosensitivities of area postrema neurons using a patch-clamp technique in rat brain slices. Results are summarized as below.1)The activation of the hyperpolarization-activated cation current (I_h) was identified in approximately 62% of area postrema neurons tested. Extracellular Cs^+ ions (2 mM) and ZD7288 (100 mM), a potent selective I_h channel antagonist, blocked I_h and induced a membrane potential hyperpolarization, suggesting the sustained activation of I_h near the resting potential and a contribution from I_h to membra...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(C), 岡山大学, Principal investigator, Competitive research funding, 15591965

静脈内鎮静法が嚥下に関連する中枢神経活動に及ぼす影響-機能的磁気共鳴画像(機能的MRI)による分析
科学研究費補助金(萌芽研究)
2002 - 2004
宮脇 卓也; 若狭 亨; 船橋 誠; 前田 茂; 浅海 淳一
本研究は,健康成人ボランティアを対象に,静脈内鎮静法によって引き起こされると考えられる,嚥下に関連した中枢神経活動への影響を,機能的磁気共鳴画像(機能的MRI)を用いることによって評価することが,目的であった。平成14年度の研究結果として,大脳皮質運動野において嚥下によって賦活する部位の神経活動が,静脈内鎮静法によって抑制される傾向がみられた。さらに前年度(平成15年度)の研究結果から,静脈内鎮静法による高位の中枢神経における嚥下動作の抑制は,静脈麻酔薬の用量依存性であることが示唆された。これらの結果をもとに,本年度は静脈麻酔薬の血中濃度と神経活動との関連を調べること,さらに,大脳皮質運動野だけでなく,脳内の各賦活領域に対して,静脈麻酔薬がどのような影響を及ぼすかを検討した。方法はこれまでと同様に,嚥下動作課題として,遠隔操作によってシリンジから1回1.5mlの蒸留水を20秒間隔で10回投与し,MR画像撮影は前交連〜後交連平面を基準に頭頂部から脳底部までとし,嚥下動作中に2秒間隔で100回撮像した。神経活動の評価として,嚥下動作課題を与え,嚥下時の機能的MRI画像から非実行時のMRI画像を差し引き,MR信号強度を算出し,T1強調画像と重ね合わせることによって,解剖学的脳賦活部位を同定した。静脈麻酔薬であるプロポフォールを最初の5分間に6mg/kg/hまたは4mg/kg/hの速...
文部科学省, 萌芽研究, 岡山大学, Competitive research funding, 14657523

Electrophysiological analysis of impulse formation in the salivary secretory neurons
Grants-in-Aid for Scientific Research(基盤研究(B))
2002 - 2003
Ryuji MATSUO; 美藤 純弘; 舩橋 誠; 小橋 基
The superior salivatory (SS) nucleus contains parasympathetic preganglionic neurons innervating the submandibular and sublingual salivary glands and those innervating the anterior part of the tongue. To evaluate mechanisms of impulse formation, we analyzed postsynaptic currents of the SS neurons. The SS neurons were labeled by injection of fluorescent tracers into the peripheral course of the neurons in neonatal Wistar rats. Two days after the injection, the brainstem was sliced and whole-cell patch-clamp recordings were obtained from the labeled neurons. The whole-cell postsynaptic current...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 岡山大学, Coinvestigator not use grants, Competitive research funding, 14370594

扁桃体単一ニューロンの膜特性および海馬体との神経回路網に関する電気生理学的研究
科学研究費補助金(奨励研究(A))
1999 - 2000
舩橋 誠
海馬体の内嗅野深層の電気刺激に誘発されるバースト発火の扁桃体外側核への伝播について,両部位を含む水平断ラット脳スライスを用いて,ガラス微小電極による細胞内記録法と金属電極によるフィールド電位記録により解析を行った。扁桃体の単一ニューロンのうち内嗅野深層ニューロンのバースト発火と同期して活動するものは主に錘体細胞に検出された。扁桃体の単一ニューロンが示した誘発電位は次の4タイプに分類された。1)内嗅野のバースト発火にほぼ相似形なバースト発火でガンマ波を含むもの,2)刺激後50msの間のみ持続する200ヘルツ程度の発火頻度を示すバースト発火,3)1発の活動電位のみ発火するもの,4)活動電位の発火は見られず興奮性シナプス後電位のみが観察されるものであった。こららの誘発電位は全て近傍のフィールド電位と同期して観察された。このことは2つの細胞から同時細胞内記録を行った実験データを用いた相関解析によっても,扁桃体外側核内の2ニューロンの顕著な活動同期性が明らかとなった。また,活動電位の発火を伴わない誘発電位を示した扁桃体外側核ニューロンはGABA-A受容体のアンタゴニストであるピクロトキシンの潅流液内への投与によってもその応答様式には変化が見られず,内嗅野からのシナプス入力自体に依存していることが示唆された。さらに,これらの誘発電位がAMPA型およびNMDA型の両方のグルタミン酸受容体を...
文部科学省, 奨励研究(A), 岡山大学, Principal investigator, Competitive research funding, 11771136

Electrophysiological analysis of brainstem neurons subserving autonomic and motor oral functions
Grants-in-Aid for Scientific Research(基盤研究(B))
1999 - 2000
Ryuji MATSUO; 美藤 純弘; 舩橋 誠; 小橋 基
Neural network in the brainstem subserving autonomic and motor oral functions was investigated by electrophysiological and behavioral studies. In the electrophysiological study, biophysical properties of the superior salivatory (SS) neurons were analyzed by the whole-cell patch clamp technique in sliced brainstem preparations. Neural activity of the trigeminal motor neurons were also analyzed by the intra-cellular recording technique in sliced preparations. The SS neurons innervating the tongue displayed a prominent transient outward current (A-current), and fired up to 70 Hz. Those innerva...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 岡山大学, Coinvestigator not use grants, Competitive research funding, 11470391

扁桃体の単一ニューロン特性及び海馬体との神経連絡に関する電気生理学的研究
科学研究費補助金(奨励研究(A))
1997 - 1998
船橋 誠
扁桃体の単一ニューロンの電気生理学的および形態学的特性を調べるとともに,海馬体のうち特に内嗅野の深層の電気刺激に誘発される鋭波(200Hz)およびガンマ波(40-100Hz)(Funahashi and Stewart,J.Physiol.510(1)191-208,1998)と扁桃体ニューロン活動の相互関係について検討を行った。扁桃体の諸核うち外側核,基底外側核および中心核の単一ニューロンについて細胞内記録を用いて脱分極性の細胞内通電(〜1mA,200ms)に対する発火パターンを調べた結果,殆どの外側核ニューロンが一般的に見られる連続発火を示し最初の数発のスパイク間隔が短いのが特徴的であった。また,基底外側核のニューロンでは強い後電位を伴うバースト発火が多く見られ,中等度の活動電位の順応が見られた。一方,中心核ニューロンでは大部分に著しい活動電位の順応を伴うバースト発火が観察された。内嗅野の電気刺激に対する応答は外側核および基底外側核のみに見られ,これらは内嗅野の鋭波およびガンマ波を含むバースト発火に同期するもので,誘発電位にIPSPが強く見られないニューロンに多く観察された。記録終了後にニューロバイオチントレーサーを注入しておいたニューロンについては記録部位の確認を行い,また細胞体および樹上突起の形態,シナプス突起の有無による形態学的分類を行った。外側核および基底外側核ニ...
文部科学省, 奨励研究(A), 岡山大学, Competitive research funding, 09771536

Electrophysiological analysis of the lateral reticular formation controlling orofacial autonomic and motor functions
Grants-in-Aid for Scientific Research(基盤研究(B))
1997 - 1998
Ryuji MATSUO; 増田 裕次; 井上 富雄; 美藤 純弘; 船橋 誠
Neural network in the brainstem subserving autonomic and motor oral functions was investigated by anatomical, electrophysiological and behavioral studies. In the anatomical study, FTTC and Rhodamine were injected into the anterior part of the tongue or the secretory nerve of the subamndibular gland, respectively, and the superior salivatory (SS) neurons innervating the tongue and those innervating the submandibular salivary glands were identified in rats. The two groups of SS neurons were similar in shape and intermingled in the lateral reticular formation. In the electrophysiological study...
Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 大阪大学->岡山大学, Competitive research funding, 09470402

ラット最後野のグルコース応答性ニューロンに関する電気生理学的研究
科学研究費補助金(奨励研究(A))
1994 - 1994
船橋 誠
脳幹レベルでの摂食飲水行動の調節について調べるために、当初、最後野のグルコース応答性ニューロンについてスライスパッチクランプ法を用いて調べる予定であったが、細胞の大きさや数などの点で有利な近接の孤束核ニューロンからの記録を行った。孤束核と最後野は密な線維連絡を持ち、共に内臓感覚の一次求心路が投射している部位としてよく知られている。本実験では孤束核ニューロンの浸透圧応答性について、最後野からの入力がある場合とない場合とで比較検討した。これによると、孤束核ニューロンは直接電気刺激によってタイプ1、2、3の三種類の発火パターンに分類できた。記録した42ニューロン中、10ニューロンがNaClによる浸透圧増加とsucroseによる浸透圧増加の両方に対して放電頻度の増加を示した。また1ニューロンが両方の浸透圧増加にたいして放電頻度の減少を示した。残りの31ニューロンは浸透圧刺激に対して何の応答も示さなかった。浸透圧応答性を示した11ニューロン中4ニューロンは[Ca^<2+>]free,high[Mg^<2+>]の条件下にて同様の実験を行った。いわゆるシナプスを遮断した状態で、3ニューロンは浸透圧応答性を保ち、1ニューロンは浸透圧応答性を失った。つまり、孤束核にはそれ自身が浸透圧受容性を持つものが存在することが明らかとなった。浸透圧応答性を失った1ニューロンはおそらく最後野からの入力を受け...
文部科学省, 奨励研究(A), 岡山大学, Competitive research funding, 06771630

Electrophysiological and microdialytic analysis on responses of dopaminergic and noradrenergic neurons in the medulla ablongata (A2aea)
Grants-in-Aid for Scientific Research(一般研究(B))
1993 - 1994
Akira ADACHI; 美藤 純弘; 船橋 誠; 小橋 基
Responses of neurons within the nucleus taractus solitarius NTS) to gastric distension were analyzed. Though no primary afferents decrease their discharge rates in response to gastric distension, some NTS neurons decreased their discharage rate resoponding to this stimulus. Convergenece to this neuron of glucose responsive visceral afferent indicates the participation of NTS on control of ingestion.Further analysis of the glucose responsive neurons within the area postrema (AP) was made on the brain tissue slice preparations so that confirmed the existence of enteroceptor neuron within this...
Ministry of Education, Culture, Sports, Science and Technology, 一般研究(B), 岡山大学, Competitive research funding, 05454502

ラット最後野中の内受容性ニューロンの受容機構に関する研究
科学研究費助成事業
1990 - 1990
船橋 誠
日本学術振興会, 奨励研究(A), 岡山大学, 02771288

摂食と延髄最後野の機能
科学研究費補助金(一般研究(C))
1990 - 1990
足立 明; 船橋 誠; 小橋 基
ラットの第IV脳室底を備品で購入したハ-バ-ド940シリンジポンプを用いてリンゲル液で表面灌流した。微小電極を用いて最後野中のニュ-ロンの電気活動を記録し、灌流液をグルコ-スを含む試験液に切り換えて、神経応答を記録した。その結果、グルコ-スに応答して放電頻度の増加するもの(グルコ-ス受容性ニュ-ロン)と、減少するもの(グルコ-ス感受性ニュ-ロン)と、2種類の異なったニュ-ロンが最後野中に存在した。両者はほぼ同数存在し、最後野中での部位的局在は認められず混在した。これらのニュ-ロンは同じ単糖類であるマンノ-スに対しては応答しないから、グルコ-スに特異的に応答することがわかった。つぎに受容機構を解明するため、2DG、ウアバイン、およびフロリジンを、それぞれ含む試験液を調製し、グルコ-ス受容性ニュ-ロン、およびグルコ-ス感受性ニュ-ロンがこれら試験液に対してどのように応答するかを検討した。グルコ-ス受容性ニュ-ロンは神経細胞膜を通過しないフロリジンに対して応答するから、ニュ-ロン膜にグルコ-スを受容する部位が存在するものと思われる。一方、グルコ-ス感受性ニュ-ロンは、グルコ-スに対しては放電頻度の減少を生じるが、2DGに対しては放電頻度が逆に増加することから考えて、従来、外側視床下野で明らかにされているグルコ-ス感受性ニュ-ロンと同様、グルコ-スが細胞内にとりこまれ、グルコ-ス代謝...
文部科学省, 一般研究(C), 岡山大学, Competitive research funding, 02670831