PhD, Tokyo Dental College

摂食・嚥下障害

口腔外科

老年歯科

Dysphagia

Oral and Maxillofacal Surgery

Oral Medicine

Gerodontology

Life Science, Social dentistry

Life Science, Surgical dentistry

Life Science, Oral biological science

Bachelor's degree program, School of Dental Medicine

Doctoral (PhD) degree program, Graduate school of Dental Medicine

Jun. 2019, Geriatrics & Gerontology International, Geriatrics & Gerontology International the 2018 Best Article Award
WATANABE Yutaka

Jun. 2017, 日本老年歯科医学会, 日本老年歯科医学賞
渡邊 裕

Jun. 2014, 第28回日本老年学会, 合同選抜ポスターセッション優秀賞
渡邊 裕

Jun. 2014, 1. 20th International Association of Gerontology and Geriatrics, Best Poster Award
Relationship between Functional Deficit of Olfactory and Feeding of Elderly People with Dementia –Especially with Concerns to Alzheimer’s Disease-
WATANABE Yutaka

2011, 日本老年歯科医学会第22回学術大会 優秀口演賞
Japan

2004, 第１回日本摂食・嚥下リハビリテーション学会奨励賞
Japan

2003, 第２１回日本口腔腫瘍学会 優秀ポスター賞
Japan

Effects of exercise and nutritional interventions on muscle-specific strength in older adults: A systematic review and meta-analysis.
Takahisa Ohta; Sho Hatanaka; Jiaqi Li; Kanae Furuya; Kaori Kinoshita; Rei Otsuka; Michiyo Kawamura; Yutaka Watanabe; Ko Matsudaira; Hiroyuki Oka; Yosuke Osuka
Ageing research reviews, 103271, 103271, 08 Aug. 2026, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: Deficient muscle-specific strength has been recognized as a key component of sarcopenia. However, the impact of various interventions on muscle-specific strength has not been systematically reviewed. This study aims to provide a systematic summary of research examining the effects of exercise, nutrition, and other interventions on muscle-specific strength in older adults. METHODS: Randomized controlled trials (RCTs) were identified through comprehensive searches of major databases. Eligible studies included adults aged 60 years or older, with interventions lasting at least 8 weeks. Studies were required to assess muscle strength normalized by muscle mass. Standardized mean differences (SMDs) were calculated using random-effects meta-analyses, and heterogeneity was evaluated using I² statistics. RESULTS: A total of 41 RCTs with 3,141 participants were included in the analysis. Interventions included resistance exercise, nutritional supplementation, aerobic exercise, concurrent training, combined exercise and nutrition, caloric restriction, and other therapies. Resistance exercise significantly improved muscle-specific strength (SMD = 0.61, 95% confidence interval: 0.27 to 0.94), although heterogeneity was observed (I² = 81%). In contrast, interventions such as aerobic exercise, concurrent training, combined exercise and nutrition, and nutritional supplementation did not lead to significant improvements in muscle-specific strength. High heterogeneity was observed across all included studies. CONCLUSIONS: Resistance exercise is the most effective intervention for improving muscle-specific strength in older adults. The effects of other interventions, such as nutritional supplementation and aerobic exercise, remain inconclusive. Further well-designed RCTs exploring diverse exercise regimens and nutritional interventions are needed to confirm these findings and identify the most effective strategies for enhancing muscle-specific strength in older populations.

Association Between Oral Frailty and Body Mass Index in Late-Stage Older Adults Stratified by Sarcopenia Status
Masaki Hayase; Kazuhito Miura; Kimiya Ozaki; Yasushi Tamada; Maki Shirobe; Keiko Motokawa; Misato Hayakawa; Hirohiko Hirano; Takahiro Ono; Eri Arai; Masanori Iwasaki; Akira Adachi; Takao Watanabe; Shigekazu Komoto; Yutaka Watanabe
Nutrients, Aug. 2026
Scientific journal

The Dietary Inflammatory Index and Periodontal Inflammation in Community-Dwelling Older Adults in Japan: The Otassha Study.
Akihiro Yuguchi; Masanori Iwasaki; Maki Shirobe; Yurie Mikami; Misato Hayakawa; Keiko Motokawa; Yoshiko Motohashi; Yuki Ohara; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Yutaka Watanabe; Hiroyuki Sasai; Shuichi Obuchi; Hirohiko Hirano
Journal of clinical periodontology, 53, 8, 1312, 1322, Aug. 2026, [Peer-reviewed], [International Magazine]
English, Scientific journal, AIM: To investigate the association between the dietary inflammatory index (DII) and periodontal inflammation (periodontal inflamed surface area [PISA]) in community-dwelling older adults in Japan. MATERIALS AND METHODS: DII scores, derived from a validated questionnaire-based dietary assessment, were categorised into quartiles. Linear regression models were used to assess the associations between DII (exposure) and log-transformed PISA (outcome) calculated from full-mouth periodontal examinations. Restricted cubic spline (RCS) models were applied to examine potential nonlinearity. RESULTS: Among the 466 participants (mean age = 73.1 years), the median PISA was 37.8 mm2, and the median values for whole-mouth average probing pocket depth, clinical attachment loss and bleeding on probing were 1.8 mm, 2.0 mm and 3.3%, respectively. After adjustment for covariates, participants in the third [regression coefficient (95% confidence interval) = 0.49 (0.03-0.95)] and fourth [0.83 (0.34-1.32)] DII quartiles had significantly higher PISA values. Although the test for nonlinearity was not significant, the RCS analysis revealed a largely flat association below DII ≈ -1.5, followed by a near-linear increase with increasing DII. CONCLUSIONS: Diets with greater inflammatory potential were associated with higher periodontal inflammatory burdens among older adults in Japan. DII may serve as a modifiable dietary indicator to support periodontal health in ageing populations.

Evaluating the Clinical Validity of the Meal Rounds Observation Form for Assessing Safe Food Intake in Patients with Dysphagia: A Multicenter Prospective Study.
Mitsuko Shimizu; Junko Fujitani; Ichiro Fujishima; Takehiro Karaho; Takeshi Kikutani; Yutaka Watanabe; Seiko Shibata; Yasushi Fujimoto; Mitsuyoshi Yoshida
Nutrients, 18, 8, 14 Apr. 2026, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background/Objectives: Providing an appropriate diet to older adults with dysphagia can prevent aspiration, choking, and nutritional deficiencies and help preserve their quality of life. Therefore, assessments for determining the appropriateness of food types are required. This multicenter study aimed to determine the reliability and validity of the Meal Rounds Observation Form (MROF), which was developed to identify food forms that can be safely consumed by older adults with dysphagia. Methods: We analyzed 532 food-texture observations obtained from 155 participants (114 men and 41 women). The reliability and validity of the MROF were compared with those of videofluoroscopic (VF) or videoendoscopic (VE) examinations of swallowing. Results: The food-form categories were water (108 pairs), 0j (54 pairs), 0t (118 pairs), 1j (20 pairs), 2-1 (28 pairs), 2-2 (37 pairs), 3 (68 pairs), 4 (67 pairs), and normal food (32 pairs) based on JDD 2021 codes. The AUC was lowest for the water (0.568) category and highest for food forms requiring chewing, such as those of the 4 and normal food (0.678) categories. The sensitivity and specificity of the Gugging Swallowing Screen were 60.1% and 69.1%, respectively (p < 0.001). The agreement between the Gugging Swallowing Screen and the MROF evaluation for food types requiring mastication was 73.2%. Logistic regression analysis revealed asymmetric movement of the corners of the mouth and coughing as important indicators when evaluating food types requiring mastication. Conclusions: The MROF is useful for determining food intake safety when VF or VE tests cannot be performed in medical and nursing care settings and can guide clinical decision-making. However, caution is required in applying it clinically because of its relatively low specificity.

Key oral hypofunction components for geriatric syndromes: Machine learning approach.
Masanori Iwasaki; Maki Shirobe; Keiko Motokawa; Yutaka Watanabe; Kentaro Igarashi; Ayako Edahiro; Naoya Arisaka; Hisashi Kawai; Hiroyuki Sasai; Shuichi Obuchi; Hiroshi Murayama; Yoshinori Fujiwara; Hirohiko Hirano
Journal of prosthodontic research, 07 Apr. 2026, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: Oral hypofunction (OHF) is defined as a multidimensional impairment of oral function that may contribute to the development of geriatric syndromes. This cross-sectional study aimed to assess the relative importance of seven OHF components in relation to physical frailty, sarcopenia, and nutritional impairment, using machine learning methods that are robust to multicollinearity. METHODS: Data were pooled from two observational studies involving community-dwelling adults aged ≥65 years. Light Gradient Boosting Machine (LightGBM) algorithm was used to calculate the SHapley Additive exPlanation (SHAP) values, reflecting the relative contribution of each OHF component in the identification of three outcomes: physical frailty, sarcopenia, and nutritional impairment. Incremental contributions were further evaluated using integrated discrimination improvement (IDI) and C-statistics, weighted by the SHAP magnitudes. RESULTS: A total of 1,133 participants (mean age 74.4 years) were included. Low tongue pressure had the highest composite SHAP value among the three outcomes (5.20), followed by low masticatory performance, occlusal force, and articulatory oral motor skills. The IDI analysis confirmed that these four components provided incremental value in identifying frailty and sarcopenia. A simplified "OHF-4" model consisting of these four components alone demonstrated comparable discriminatory performance to the full seven-component model across all outcomes based on the C-statistics comparisons. CONCLUSIONS: Four OHF components-low tongue pressure, masticatory performance, occlusal force, and articulatory oral motor skills -were the most informative indicators of geriatric syndromes. Targeting these specific functions may aid the development of effective oral function management strategies to mitigate the risk of geriatric syndromes.

Interprofessional nutrition and dysphagia management for care-dependent older adults in day-care services: a non-randomized controlled trial.
Hiroyasu Furuya; Takeshi Kikutani; Yukie Ishiguro; Yuko Kuboyama; Keiko Motokawa; Yutaka Watanabe; Fumiyo Tamura
European geriatric medicine, 17, 2, 1049, 1058, Apr. 2026, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: Malnutrition and dysphagia in older adults complicate the maintenance of independent living. This study aimed to evaluate a dietary observation and assessment model by non-specialized staff and a consultation and support model by specialized staff in adult day services (ADS). METHODS: This non-randomized controlled trial was conducted across 31 ADS facilities in Japan. Participants were care-dependent older adults (n = 590; median age, 85 years; 69% female) for whom a 6-month follow-up assessment was completed, including body weight measurement, diet texture documentation, and Functional Oral Intake Scale (FOIS) scoring. The intervention group (n = 317) received 3 months of monthly mealtime observation by non-specialized staff, with targeted consultation from specialists (dental hygienists, dietitians) for individuals at risk, whereas the control group (n = 273) received usual care. The primary outcome was weight loss of ≥ 5% at 6 months, analyzed using a mixed-effects model. Sensitivity analyses were performed to assess the impact of attrition. RESULTS: The incidence of ≥ 5% weight loss was significantly lower in the intervention group than in the control group (10.1% vs 17.3%; adjusted odds ratio 0.52, 95% confidence interval 0.31-0.89). This finding was upheld in a realistic sensitivity scenario. The intervention group showed a significantly greater increase in the use of texture-modified diets (p = 0.039) without a change in oral intake ability. CONCLUSION: An interprofessional model combining observation by non-specialized staff with targeted specialist support offers a promising, efficient, and scalable strategy to mitigate the risk of weight loss in older adults who attend day-care settings. TRIAL REGISTRATION: UMIN000056668, 2025/01/08, retrospectively registered.

Association between Poor Appetite and Nutrient Intake in Community-Dwelling Older Adults: The Otassha Study.
Yurie Mikami; Keiko Motokawa; Maki Shirobe; Masanori Iwasaki; Tatsunosuke Gomi; Misato Hayakawa; Lena Käläntär; Yasuyuki Sakata; Yutaka Watanabe; Hisashi Kawai; Shuichi Obuchi; Yoshinori Fujiwara; Kazushige Ihara; Hirohiko Hirano
JMA journal, 9, 2, 511, 516, 16 Mar. 2026, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, INTRODUCTION: Poor appetite is a prevalent and serious problem among older adults. However, real-world data regarding appetite and nutrient intake among community-dwelling older adults are scarce. The aim of this study was to clarify the association between appetite and nutrient intake status among community-dwelling older adults. METHODS: This cross-sectional study involved participants (N = 583) from the cohort of the "Otassha study," conducted among community-dwelling older adults. Appetite was assessed using the Japanese version of the Simplified Nutritional Appetite Questionnaire. Nutrient intake was calculated using the Brief-Type Self-Administered Diet History Questionnaire. In addition, compliance status was assessed using the recommended dietary allowance (RDA) of various nutrients based on the "Dietary Reference Intakes for Japanese (2020)." The association between compliance status and appetite was analyzed using logistic regression, with the RDA of multiple nutrients as the dependent variable and poor appetite as the independent variable. RESULTS: In the study population, 32.1% of participants had poor appetite. Multivariable logistic regression revealed that poor appetite was significantly associated with insufficient vitamin C intake relative to the RDA (odds ratio 1.67; 95% confidence interval 1.08-2.57). CONCLUSIONS: This study demonstrated an association between poor appetite and vitamin C intake among community-dwelling older adults.

Relationship between end of life of older adults in long-term care facilities and full-time dental hygienist service: A 2-year multicenter study.
Nami Machi; Yutaka Watanabe; Kazuhito Miura; Kimiya Ozaki; Misuzu Sato; Masanori Iwasaki; Maki Shirobe; Hirohiko Hirano; Yuki Ohara; Yoshihiro Kugimiya; Masataka Itoda; Takeshi Kikutani; Midori Tsuneishi; Yuko Kuboyama; Shinsuke Mizutani; Shigekazu Komoto; Yutaka Yamazaki
Geriatrics & gerontology international, 25, 10, 1404, 1411, Oct. 2025, [Peer-reviewed], [Corresponding author], [Domestic magazines]
English, Scientific journal, AIM: This study aimed to examine the relationship between dental hygienist work arrangements in long-term care insurance facilities and the likelihood of residents dying in the facility (in-facility death) rather than in a hospital (hospital death). METHODS: In this 2-year, multicenter, longitudinal study, a baseline survey of 958 residents from 30 long-term care insurance facilities was conducted in 2019, followed by a 2-year outcome survey. The survey items comprised end-of-survey outcomes (death, inpatient discharge), length of stay, and resident preferences for end-of-life care in the facility. A modified Poisson analysis was conducted, with the dependent variable end of life in the facility coded as 1 (possible) or 0 (not possible) and whether the facility had a full-time hygienist representing the primary explanatory variable. RESULTS: Of the 958 residents (202 men and 742 women; mean age: 86.3 ± 8.1 years) included in the study, 464 were in the facility discharge group, and of these 142 (37.3%) died in the hospital and 239 (62.7%) died in the facility. Having access to a full-time dental hygienist (risk ratio [RR]: 1.23, 95% confidence interval [CI]: 1.03-1.46) and a preference for end of life in the facility (RR: 1.48, 95% CI: 1.23-1.79) were significantly associated with the end of life in the facility. CONCLUSIONS: The presence of a full-time dental hygienist in long-term care insurance facilities was associated with end of life in the facility for older adult residents requiring long-term care. Geriatr Gerontol Int 2025; ••: ••-••., 50564722;30259965;27709218

口腔カンジダ症に対するミコナゾールゲルとアムホテリシンBシロップの菌種別治療効果の比較検討
尾崎 公哉; 稲本 香織; 大平 匡徹; 坂田 健一郎; 浅香 卓哉; 三浦 和仁; 渡邊 裕; 山崎 裕
北海道歯学雑誌, 46, 29, 35, 北海道歯学会, Sep. 2025, [Peer-reviewed]
Japanese

Oral Health Management by Dental Hygienists and Older Adults' Food Forms in Long-Term Care Facilities: A 1-Year Longitudinal Study.
Kaoru Inamoto; Kimiya Ozaki; Yutaka Watanabe; Yutaka Yamazaki; Yuki Ohara; Masanori Iwasaki; Hirohiko Hirano; Midori Tsuneishi; Tsuyoshi Kodama; Mitsuyoshi Yoshida; Shunsuke Minakuchi
Gerodontology, 42, 3, 416, 428, Sep. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, OBJECTIVE: To date, no studies have directly investigated the association between oral health management (OHM) and food forms. Therefore, this study aimed to investigate the association between OHM by dental hygienists and food forms in older adults admitted to long-term care facilities (LTCFs). BACKGROUND: OHM involves oral health maintenance by dental hygienists and may prevent weight loss and pneumonia in older adults admitted to LTCFs. MATERIALS AND METHODS: Older adults in LTCFs in Japan (n = 273) who participated in baseline (2018) and follow-up (2019) surveys were evaluated. Basic characteristics, medical history, OHM status, oral maintenance management status, food forms, and oral conditions were investigated at baseline. After 1 year, a follow-up survey was conducted only on food items. Furthermore, factors associated with the maintenance or improvement in food forms after 1 year were examined using binomial logistic regression analysis. RESULTS: Overall, 273 (69.2%) older adults in LTCFs required OHM by dental hygienists during the follow-up year, of whom 142 (52.0%) received OHM and 88 maintained or improved their regular diet. The analyses revealed that the maintenance or improvement in food forms after 1 year was significantly associated with OHM implementation (odds ratio: 2.01, 95% confidence interval: 1.03-3.90). CONCLUSION: OHM in older adults in Japanese LTCFs was associated with the maintenance or improvement in food forms, emphasising the importance of OHM for these individuals. OHM may also maintain or improve eating and swallowing functions, improving nutritional status., 30259965;27709218

Periodontal Inflammation and Serum Inflammatory Markers in Community-Dwelling Older Adults in Japan: The Otassha Study.
Masanori Iwasaki; Maki Shirobe; Yuki Ohara; Keiko Motokawa; Takashi Shida; Yoshiko Motohashi; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Yutaka Watanabe; Hiroyuki Sasai; Shuichi Obuchi; Hirohiko Hirano
Journal of clinical periodontology, 52, 8, 1099, 1107, Aug. 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, AIM: To investigate the associations between periodontal inflammation-as determined by the periodontal inflamed surface area (PISA)-and serum inflammatory markers in community-dwelling older adults in Japan. MATERIALS AND METHODS: This cross-sectional study included 470 adults (mean age: 73.1 years). The composite inflammatory marker z-score (CIMZ) was calculated as the sum of the participants' individual z-scores for C-reactive protein (CRP), interleukin-1beta (IL-1β), IL-6 and tumour necrosis factor-α (TNF-α). The associations of PISA (quartiles) with individual biomarkers (continuous, log-transformed) and CIMZ (dichotomized, highest quartile or not) were assessed using linear or Poisson regression models. RESULTS: Compared with participants in the lowest PISA quartile (Q1), those in Q3 and Q4 had significantly (p < 0.05) higher CRP and IL-6 levels. Statistically significant linear trends (ptrend < 0.05) across the PISA quartiles were observed for CRP and IL-6. The multivariable adjusted prevalence ratios (95% confidence intervals) of high CIMZ (reference: Q1) were 1.20 (0.68-2.14), 1.66 (0.96-2.88) and 1.90 (1.08-3.34) (ptrend = 0.01) in individuals in PISA Q2-Q4. CONCLUSIONS: Older adults with high periodontal inflammation had high serum CRP and IL-6 concentrations and composite summary inflammatory indicator values. Periodontal inflammation is a potential modifiable factor of elevated inflammatory status among older adults in Japan.

Intervention Response of Muscle Architecture and Composition Markers Assessed via Ultrasound Imaging: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Yosuke Osuka; Takahisa Ohta; Jiaqi Li; Kanae Furuya; Kaori Kinoshita; Rei Otsuka; Michiyo Kawamura; Yutaka Watanabe; Ko Matsudaira; Hiroyuki Oka; Sho Hatanaka
Journal of the American Medical Directors Association, 26, 5, 105526, 105526, May 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: To evaluate the response of skeletal muscle architecture (fascicle length and pennation angle) and composition (echo intensity) markers assessed by ultrasonography to intervention in older adults. DESIGN: This is a subsection of a more comprehensive systematic review of clinical trials focusing on changes in muscle quality, registered in PROSPERO (registration number: CRD42022357116). SETTING AND PARTICIPANTS: Randomized controlled trials evaluating the effectiveness of interventions lasting ≥8 weeks in adults aged ≥60 years on fascicle length, pennation angle, and echo intensity. METHODS: After the literature search, 6 peer reviewers and 1 decider conducted a 2-stage screening process, including studies that met the eligibility criteria. Random-effects modeling for Hedges' g was applied to a meta-analysis of studies with sufficient data. The risk of bias in the included studies was assessed using version 2 of the Cochrane Risk-of-Bias tool for randomized trials. RESULTS: In total, 4832 studies were initially searched, and 28 trials involving 1101 participants were included. Six trials were analyzed for fascicle length, 8 for pennation angle, and 8 for echo intensity. The standardized mean differences with 95% CIs, where a positive direction indicates improvement due to treatment, were fascicle length, -0.04 (-0.27 to 0.19); pennation angle, 0.08 (-0.02 to 0.18); and echo intensity, 0.00 (-0.02 to 0.02). No heterogeneity was observed for the outcomes (I2 = 0%). The Cochrane Risk-of-Bias tool showed that 78.6% of the trials had a high risk of bias. CONCLUSIONS AND IMPLICATIONS: Muscle architecture and composition markers assessed via ultrasound did not respond to the intervention. Further well-designed clinical trials are necessary to confirm the clinical validity of these markers.

Effectiveness of salivary-gland and oral-mucosa massage in alleviating xerostomia in patients with schizophrenia
Yuki Iwashima; Yutaka Watanabe; Kimiya Ozaki; Eri Arai; Kazuhito Miura; Ayako Yokoyama; Miyako Kondo; Seitaro Nakazawa; Matsuhiko Oka; Kazutaka Okada; Takae Matsushita; Yutaka Yamazaki
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, May 2025, [Peer-reviewed], [Corresponding author]
Scientific journal

Predictive Factors for Swallowing Function Decline in Older Adults With Alzheimer's Disease: A 1-Year Longitudinal Study.
Maki Shirobe; Ayako Edahiro; Keiko Motokawa; Shiho Morishita; Yuki Ohara; Yutaka Watanabe; Masanori Iwasaki; Hirohiko Hirano
Journal of oral rehabilitation, 52, 3, 375, 383, Mar. 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: By 2060, the global burden of dementia, particularly Alzheimer's disease (AD), is expected to increase significantly, necessitating effective palliative care strategies. Dysphagia, a common condition among people with dementia, leads to malnutrition, aspiration pneumonia, and a reduced quality of life. OBJECTIVE: This study aimed to identify oral health management factors that could predict a decline in swallowing function in older adults with AD. METHODS: Data from the Akita-Omorimachi study, which included 63 adults diagnosed with AD, were analysed. Swallowing function was assessed using the modified water-swallowing test (MWST) at baseline and after 1 year. RESULTS: The results indicated that 25.4% of participants exhibited a decline in swallowing function, as indicated by a decrease from the highest MWST score of 5 at baseline to a lower score at follow-up. Poisson regression analysis revealed that refusal of oral care (incidence rate ratio (IRR): 7.28), tongue coating (IRR: 4.21), and unclear articulation of /ka/ (IRR: 5.79) were significant predictors of swallowing function decline. The participants with these indicators had a higher risk of developing dysphagia. CONCLUSIONS: These findings suggest that factors related to specific oral health problems may predict poor swallowing function in older adults with AD. Moreover, implementing targeted oral care interventions, including person-centered care and regular tongue cleaning, may improve the outcomes in this vulnerable population. Despite the limitations of this study, including a small sample size, the results underscore the importance of comprehensive oral health management in preventing dysphagia-related complications.

Association of oral frailty with medical expenditure in older Japanese adults: The study of late-stage older adults in Tottori (START Tottori).
Eri Arai; Yutaka Watanabe; Sayuri Nakagawa; Yuki Ohara; Masanori Iwasaki; Hirohiko Hirano; Kazunori Ikebe; Takahiro Ono; Katsuya Iijima; Akira Adachi; Takao Watanabe; Yutaka Yamazaki
Gerodontology, 42, 1, 61, 70, Mar. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, OBJECTS: This study aimed to determine the association between annual medical expenses and oral frailty in later-stage older adults (aged ≥ 75 years). No studies have investigated the association between medical costs and oral frailty, which would elucidate the association between oral frailty and the deterioration of mental and overall physical function. MATERIALS AND METHODS: In this cross-sectional study, 2190 adults (860 men and 1330 women aged 75-94 years) covered by the Medical System for the Elderly and residing in Tottori Prefecture, Japan, between April 2016 and March 2019, were included. Participants were classified into three groups: healthy, pre-orally frail or orally frail, based on dental health screening findings. The medical and dental expenses over the years, number of days of consultations and comorbidities were obtained from the Japanese Health Insurance Claims Database. RESULTS: The number of days of medical and dental consultations and annual medical expenses for outpatient care differed among the three study groups. A significant association was observed between oral frailty and high annual expenses for outpatient medical and dental care. Oral frailty was associated with higher medical expenses in participants with poor masticatory function. Higher and lower dental expenses were associated with subjective poor masticatory function and subjective impairment of swallowing function respectively. CONCLUSION: Medical and dental expenses for orally frail older adults are high, indicating that oral frailty may be related to the occurrence and severity of diseases other than oral health issues. Future studies should examine the mechanism by which oral weakness affects physical and mental functions.

Association Between Undernutrition and the Number of Molar Occlusions in Older Persons Requiring Care in Long-Term Care Insurance Facilities.
Koji Takahashi; Yutaka Watanabe; Takuma Okumura; Yasushi Tamada; Misuzu Sato; Masanori Iwasaki; Maki Shirobe; Hirohiko Hirano; Yoshihiro Kugimiya; Masako Kishima; Kayoko Ito; Yasuyuki Iwasa; Yoshihiko Watanabe; Shinsuke Mizutani; Kazuharu Nakagawa; Shigekazu Komoto; Yutaka Yamazaki
Nutrients, 17, 4, 10 Feb. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, Background/Objectives: Undernutrition increases the mortality risk in older persons requiring long-term care; further, it is associated with oral functions such as swallowing and chewing. Moreover, occlusion affects oral function and is crucially involved in nutritional intake. The present study aimed to examine the association between the number of molar occlusions and undernutrition according to body mass index (BMI) in older persons requiring long-term care. Methods: Japanese older persons requiring long-term care were categorized based on BMI (<20 kg/m2 vs. 20 kg/m2). We examined the association between undernutrition and the number of molar occlusions (one in each of the left and right premolars and molars, for a total of four). Results: Among 893 included participants, 440 (49.3%) had BMI < 20 kg/m2 and 453 (50.7%) had BMI > 20 kg/m2. Binomial logistic regression analysis revealed that BMI < 20 kg/m2 was significantly associated with increased number of molar occlusions (odds ratio: 0.52-0.70, 95% CI: 0.28-1.00). This indicated that a decrease in the number of molar occlusions was associated with malnutrition as determined through BMI in older persons requiring long-term care and residing in long-term care insurance facilities in Japan. Conclusions: Our findings suggest that maintaining occlusal support may help maintain nutritional status in older persons requiring long-term care.

A clinical study of burning mouth syndrome concomitant with oral candidiasis
Ohira Masayuki; Miura Kazuhito; Ozaki Kimiya; Yokoyama Ayako; Watanabe Yutaka; Yamazaki Yutaka
Journal of Psychosomatic Oral Medicine, 39, 1-2, 10, 17, Japanese Society of Psychosomatic Dentistry, 2025, [Peer-reviewed]
Japanese, Burning mouth syndrome （BMS） and oral candidiasis are common conditions among patients reporting tongue pain. While these diseases can occur independently, they sometimes present concomitantly. However, the clinical characteristics of such concomitant cases have not been well documented. In this study, we analyzed 211 patients diagnosed with BMS and treated at our department over the past nine years. The patients were divided into two groups: 71 patients with concomitant oral candidiasis, confirmed by a positive Candida cultivation test at their first visit, and 140 patients with isolated BMS, confirmed by a negative Candida cultivation test.

Comparing background factors, the concomitant group was significantly older and more likely to report pain when ingesting stimulants, subjective dry mouth, and higher visual analog scale score for tongue pain at their first visit compared to the isolated BMS group （p＜0.05）. However, multivariate analysis, using oral candidiasis as the dependent variable and these factors as explanatory variables, identified age as the only significant factor. The concomitant group demonstrated a significantly worse prognosis than the isolated BMS group. However, the prognosis was not influenced by treatment approaches for candidiasis or the presence or absence of Candida eradication. Furthermore, no difference in prognosis was observed between the two groups depending on the BMS treatment.
These findings indicate that when BMS occurs concomitantly with oral candidiasis, the prog­no­sis is poorer. However, associated factors, such as the nature of tongue pain, tend to be similar to those of BMS. This similarity makes diagnosis challenging based only on medical history or physical examination, emphasizing the importance of Candida cultivation testing.

Oral frailty and its association with systemic health: A narrative review
Yutaka Watanabe; Nami Matsuda; Kazuhito Miura; Yuki Ohara; Masanori Iwasaki; Hirohiko Hirano; Kazunori Ikebe; Katsuya Iijima; Yukari Kono; Yutaka Yamazaki
Oral Science International, Jan. 2025, [Peer-reviewed], [Lead author, Corresponding author]
Scientific journal

長期経過のなかで含嗽療法と支持的精神療法が奏効した口腔異常感症の1例
阿部 美也子; 新井 絵理; 横山 亜矢子; 三浦 和仁; 尾崎 公哉; 渡邊 裕; 山崎 裕
北海道歯学雑誌, 45, 50, 55, 北海道歯学会, Sep. 2024, [Peer-reviewed]
Japanese

補中益気湯が高齢者の味覚異常や舌痛とともに全身状態にも奏功した3例
横山 亜矢子; 三浦 和仁; 新井 絵理; 尾崎 公哉; 渡邊 裕; 山崎 裕
北海道歯学雑誌, 45, 63, 68, 北海道歯学会, Sep. 2024, [Peer-reviewed]
Japanese

Association between oral frailty and Prevotella percentage in the oral microbiota of community-dwelling older adults who participated in the CHEER Iwamizawa project, Japan.
Chizuru Kimura; Kazuhito Miura; Yutaka Watanabe; Haruhisa Baba; Kimiya Ozaki; Akira Hasebe; Tokiyoshi Ayabe; Kiminori Nakamura; Shinji Nakaoka; Katsuhiko Ogasawara; Teppei Suzuki; Hiroshi Saito; Takashi Kimura; Akiko Tamakoshi; Yutaka Yamazaki
Journal of oral rehabilitation, 51, 9, 1721, 1729, Sep. 2024, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, BACKGROUND: Prevotella bacteria are associated with inherent diseases of the oral cavity, such as periodontal disease, and systemic diseases. Oral frailty (OF) has been associated with nursing necessity and death. However, the relationship between OF and oral microbiota has not been fully clarified. OBJECTIVE: This cross-sectional study investigated the association between OF and Prevotella percentage in the oral microbiota of community-dwelling older adults. METHODS: Oral bacteria species from saliva were identified in 208 community-dwelling older individuals aged ≥60 years in Japan. The proportion of Prevotella in the oral microbiota was classified into three tertile groups, and its relationship with each test item for OF (number of remaining teeth, masticatory performance, oral diadochokinesis, tongue pressure, difficulties eating tough foods, difficulties swallowing tea or soup, number of applicable OF judgement items, and existence of OF) was examined using ordinal logistic regression analysis. RESULTS: The Prevotella proportions were classified into lower, middle and upper groups, comprising 70, 69 and 69 participants, respectively. The three groups showed a significant relationship between the number of remaining teeth (odds ratio [OR]: 0.946, 95% confidence interval [CI]: 0.915-0.977), masticatory performance (OR: 0.897, 95% CI: 0.844-0.953), number of applicable OF judgement items (OR: 1.477, 95% CI: 1.14-1.915), and existence of OF (OR: 4.194, 95% CI: 1.519-11.576). CONCLUSION: The proportion of Prevotella in oral microbiota was high in individuals with OF. Among the older adults, the type of oral microbiota and systemic diseases may be related to the examination and management of oral function decline.

Oral frailty, appetite and dietary variety in late-stage older adults: A cross-sectional study (the STudy of lAte-stage oldeR adulTs in Tottori; START Tottori).
Sayuri Nakagawa; Kazuhito Miura; Eri Arai; Kenshu Taira; Yutaka Watanabe; Maki Shirobe; Keiko Motokawa; Yuki Ohara; Masanori Iwasaki; Hirohiko Hirano; Takahiro Ono; Akira Adachi; Takao Watanabe; Yutaka Yamazaki
Geriatrics & gerontology international, 24, 6, 626, 633, Jun. 2024, [Peer-reviewed], [Corresponding author], [Domestic magazines]
English, Scientific journal, AIM: Efforts to combat frailty and preserve good health in older adults have highlighted oral frailty as an early indicator of overall frailty. Individuals showing oral frailty are at an elevated risk of insufficient nutritional intake compared with those without oral frailty; however, underlying mechanisms remain poorly explored. In this cross-sectional study, we aimed to examine the link between oral frailty and undernutrition, especially regarding poor appetite and low dietary diversity. METHODS: The analysis included 2727 late-stage older adults (mean age 79.9 ± 4.3 years) who underwent dental checkups in a prefecture in Japan from 2016 to 2020. The examination involved a questionnaire survey (covering basic information, frailty screening index, appetite index: Simplified Nutritional Appetite Questionnaire; and dietary variety: Dietary Variety Score) and a measurement survey (including intraoral confirmation, oral diadochokinesis and masticatory efficiency test). Individuals with three or more indications of poor oral function, identified through oral function assessment, were defined as showing oral frailty. Binomial logistic regression and path analyses examined associations among oral frailty, Simplified Nutritional Appetite Questionnaire and Dietary Variety Score. RESULTS: Among those analyzed, 1208 (44.3%) participants were categorized into the oral frailty group. Binomial logistic regression analysis showed that Simplified Nutritional Appetite Questionnaire (odds ratio for oral frailty per 1-point increase 0.88, 95% confidence interval 0.84-0.93) and Dietary Variety Score (odds ratio 0.95, 95% confidence interval 0.92-0.98) were significantly associated with oral frailty. The path analysis showed individual associations between each examined factor. CONCLUSIONS: Oral frailty was associated with decreased appetite and dietary variety in late-stage older adults. Geriatr Gerontol Int 2024; ••: ••-••.

Feasibility of Oral Function Evaluation According to Dementia Severity in Older Adults with Alzheimer's Disease.
Maki Shirobe; Ayako Edahiro; Keiko Motokawa; Shiho Morishita; Yoshiko Motohashi; Chiaki Matsubara; Masanori Iwasaki; Yutaka Watanabe; Hirohiko Hirano
Nutrients, 16, 7, 28 Mar. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, Oral function evaluation in older adults with dementia is important for determining appropriate and practical dietary support plans; however, it can be challenging due to their difficulties in comprehending instructions and cooperating during assessments. The feasibility of oral function evaluation has not been well studied. This cross-sectional study aimed to determine the feasibility of oral function evaluation in older adults with Alzheimer's disease (AD) according to Functional Assessment Staging of Alzheimer's Disease (FAST) stages. In total, 428 older adults with AD (45 men and 383 women; mean age: 87.2 ± 6.2 years) were included. Multilevel logistic regression models were used to examine the prevalence of participants who were unable to perform oral function evaluations, including oral diadochokinesis (ODK), repeated saliva swallow test (RSST), and modified water swallow test (MWST). In comparison to the reference category (combined FAST stage 1-3), FAST stage 7 was associated with the infeasibility of ODK (adjusted odds ratio, 95% confidence interval = 26.7, 4.2-168.6), RSST (5.9, 2.2-16.1), and MWST (8.7, 1.6-48.5, respectively). Oral function evaluation is difficult in older adults with severe AD. Simpler and more practical swallowing function assessments and indicators that can be routinely observed are required.

Present state and perceived future use of teledentistry in long-term care facilities in Japan: A cross-sectional study.
Takuma Okumura; Kazuharu Nakagawa; Kanako Yoshimi; Mitsuko Saito; Kayoko Ito; Masataka Itoda; Kenji Takeuchi; Shinsuke Mizutani; Mitsuyoshi Yoshida; Yutaka Watanabe; Haruka Tohara
Digital health, 10, 20552076241282394, 20552076241282394, 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Teledentistry could be effective in managing oral health through the provision of oral hygiene instruction and diagnostic services. This study aimed to assess the perception and usefulness of teledentistry in Japanese long-term care facilities. METHODS: We conducted a questionnaire survey to compare related factors of the usefulness of teledentistry and identify issues in its implementation. We chose 1000 facilities using a stratified random sampling method. The questionnaires were sent to the facilities in August 2021 and collected in December of the same year. Responses to the questionnaire items regarding the usefulness of teledentistry for oral management were divided into three groups according to the answer: perceiving teledentistry as "useful," "not useful," or "neither," including facilities that do not currently use teledentistry. RESULTS: In total, 26.1% (261) responded to the questionnaire, and among these, 184 facilities answered the question regarding the usefulness of teledentistry. Only two of these facilities implemented teledentistry. Facilities with dental hygienists (p = 0.040) and those that receive insured medical treatment: reimbursement for oral feeding maintenance II (p = 0.040) tended to perceive teledentistry as useful in the management of patients with coronavirus disease. The higher the number of services that responded to the question "what kind of services do you think can be provided via teledentistry?" the higher the percentage of "useful" responses. CONCLUSIONS: Although only a few facilities use teledentistry, many long-term care facilities perceive it as useful even without using it. The presence of dental hygienists and interprofessional work done with reimbursement for oral feeding maintenance II contributed to the perception of the usefulness of teledentistry in long-term care facilities.

Association Between Ego-Resilience and Social Isolation Among Urban Older People.
Kazuaki Hashimoto; Takeaki Takeuchi; Kazushige Ihara; Shuichi Obuchi; Hisashi Kawai; Hirohiko Hirano; Yoshinori Fujiwara; Kim Hunkyung; Yutaka Watanabe; Masahiro Hashizume
Gerontology & geriatric medicine, 10, 23337214241238069, 23337214241238069, SAGE Publications, Jan. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal, Social isolation among older adults affects their physical and mental health. Ego-resilience is associated with flexible adaptation to various environments and acceptable behaviors. However, its association with social isolation among older people is unclear. Therefore, a health survey was conducted with 510 adults aged 65 years or older to assess social isolation, its associated factors, and ego resilience. The results showed that the social isolation group had a lower median ego-resiliency scale score (42.0) compared to the non-social isolation group (38.0). The social isolation group were mostly males without spouses, took time to move, had more depressive moods, and poorer subjective health status. The non-social isolated group had faster maximum walking speed. Low ego-resilience was newly identified as a factor associated with social isolation among older people, as were being male, having no spouse, and depressive symptoms. Mediation analysis revealed that ego-resilience affected social isolation and was partially mediated by depressive symptoms.

非定型歯痛に対する漢方薬の有効性に関する研究
新井 絵理; 横山 亜矢子; 尾崎 公哉; 渡邊 裕; 山崎 裕
日本歯科心身医学会雑誌, 38, 1-2, 8, 14, (一社)日本歯科心身医学会, Dec. 2023, [Peer-reviewed]
Japanese

COVID-19の影響で発症したと思われる舌痛再燃症例に対し,エスシタロプラムと行動療法が奏功した1例
稲本 香織; 平良 賢周; 新井 絵理; 尾崎 公哉; 渡邊 裕; 山崎 裕
日本歯科心身医学会雑誌, 38, 1-2, 39, 42, (一社)日本歯科心身医学会, Dec. 2023, [Peer-reviewed]
Japanese

「口腔セネストパチー」の概念的整理 診断,病態生理,治療に関するナラティブブレビュー
梅崎 陽二朗; 豊福 明; 松岡 紘史; 古賀 千尋; 北川 善政; 山崎 裕; 高田 訓; 金光 芳郎; 森谷 満; 岡田 智雄; 篠崎 貴弘; 福田 謙一; 伊藤 幹子; 楠川 仁悟; 小佐野 仁志; 松本 尚之; 宗像 源博; 今 一裕; 岩瀬 陽子; 吉岡 泉; 渡邊 裕; 村上 聡; 吉川 達也; 宇津宮 雅史; 美久月 瑠宇; 内藤 徹; 安彦 善裕
日本歯科心身医学会雑誌, 38, 1-2, 48, 60, (一社)日本歯科心身医学会, Dec. 2023, [Peer-reviewed]
Japanese

歯科訪問診療における感染予防策の指針 2023年版
水口 俊介; 古屋 純一; 小玉 剛; 猪原 光; 金久 弥生; 菊谷 武; 玉田 泰嗣; 花形 哲夫; 日高 玲奈; 若杉 葉子; 渡邊 裕; 渡部 芳彦; 畑中 幸子; 吉田 光由; 猪原 健; 河野 雅臣; 佐藤 繭美; 宮本 雄気; 高木 理史; 一般社団法人日本老年歯科医学会, 在宅歯科医療委員会, 一般社団法人日本在宅医療連合学会
老年歯科医学, 38, 3, E29, E62, (一社)日本老年歯科医学会, Dec. 2023, [Peer-reviewed]
Japanese

Towards an operational definition of oral frailty: A e-Delphi study.
Karl G H Parisius; Merel C Verhoeff; Frank Lobbezoo; Limor Avivi-Arber; Joke Duyck; Hirohiko Hirano; Katsuya Iijima; Barbara Janssens; Anastassia Kossioni; Chia-Shu Lin; Gerald McKenna; Frauke Müller; Martin Schimmel; Anita Visser; Yutaka Watanabe; Robbert J J Gobbens
Archives of gerontology and geriatrics, 117, 105181, 105181, 06 Sep. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Building upon our recently developed conceptual definition of oral frailty (the age-related functional decline of orofacial structures), this e-Delphi study aims to develop an operational definition of oral frailty by identifying its components. METHODS: We used a modified e-Delphi study to reach a consensus among international experts on the components of oral frailty. Twelve out of fifteen invited experts in the field of gerodontology participated. Experts responded to three rounds of an online 5-point scale questionnaire of components to be included or excluded from the operational definition of oral frailty. After each round, scores and rationales were shared with all experts, after which they could revise their position. A consensus was reached when at least 70% of the experts agreed on whether or not a component should be included in the operational definition of oral frailty. RESULTS: The experts achieved a high level of agreement (80 - 100%) on including eight components of oral frailty and excluding nineteen. The operational definition of oral frailty should include the following components: 1) difficulty eating hard or tough foods, 2) inability to chew all types of foods, 3) decreased ability to swallow solid foods, 4) decreased ability to swallow liquids, 5) overall poor swallowing function, 6) impaired tongue movement, 7) speech or phonatory disorders, and 8) hyposalivation or xerostomia. CONCLUSION: This e-Delphi study provided eight components that make up the operational definition of oral frailty. These components are the foundation for the next stage, which involves developing an oral frailty assessment tool.

Validation of self-reported articulatory oral motor skill against objectively measured repetitive articulatory rate in community-dwelling older Japanese adults: The Otassha Study.
Masanori Iwasaki; Maki Shirobe; Keiko Motokawa; Misato Hayakawa; Kazuhito Miura; Lena Kalantar; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Yutaka Watanabe; Shuichi Obuchi; Hirohiko Hirano
Geriatrics & gerontology international, 23, 10, 729, 735, 06 Sep. 2023, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: To assess the validity of self-reported articulatory oral motor skill against objectively measured repetitive articulatory rate (oral diadochokinesis [oral-DDK]) as a gold standard index for articulatory oral motor skill in community-dwelling older Japanese adults. METHODS: This cross-sectional study included 607 Japanese adults (mean age = 73.9 years). A single-item self-report questionnaire for articulatory oral motor skill was developed. Study participants completed a 1-month-interval test-retest protocol to assess reliability of the questionnaire, and the protocol was tested by the kappa statistic. Oral-DDK with /ta/ (i.e., the number of repetitions of the monosyllable /ta/ per second) was measured during the on-site examination. Low oral-DDK performance was defined as <5.2 times/s in men and <5.4 times/s in women. Oral-DDK performance, oral functions other than articulatory oral motor skill, and physical frailty were compared in the groups with and without self-reported low articulatory oral motor skill as determined by the response to the questionnaire. RESULTS: Self-reported low articulatory oral motor skill was identified in 18.5% of the study population. The self-report questionnaire had good test-retest reliability, with a kappa statistic of 0.71. Self-reported low articulatory oral motor skill was significantly associated with a lower value of oral-DDK with /ta/ and a higher proportion of low oral-DDK performance, difficulties in chewing and swallowing, dry mouth, and physical frailty. Self-report had high specificity (83.1%) but low sensitivity (42.1%) for detecting low oral-DDK performance. CONCLUSIONS: A single-item self-report questionnaire for articulatory oral motor skill had acceptable test-retest reliability and was associated with objectively measured articulatory oral motor skill. Geriatr Gerontol Int 2023; ••: ••-••.

当初は舌痛症が疑われたが,長期経過の後にガンマナイフが奏功した高齢女性の典型的三叉神経痛の1例
松田 捺美; 平良 賢周; 新井 絵理; 尾崎 公哉; 山野 茂; 渡邊 裕; 山崎 裕
北海道歯学雑誌, 44, 107, 112, 北海道歯学会, Sep. 2023, [Peer-reviewed]
Japanese

Association between Death or Hospitalization and Observable Variables of Eating and Swallowing Function among Elderly Residents in Long-Term Care Facilities: A Multicenter Prospective Cohort Study.
Maaya Takeda; Yutaka Watanabe; Kenshu Taira; Kazuhito Miura; Yuki Ohara; Masanori Iwasaki; Kayoko Ito; Junko Nakajima; Yasuyuki Iwasa; Masataka Itoda; Yasuhiro Nishi; Yoshihiko Watanabe; Masako Kishima; Hirohiko Hirano; Maki Shirobe; Shunsuke Minakuchi; Mitsuyoshi Yoshida; Yutaka Yamazaki
Healthcare (Basel, Switzerland), 11, 13, 22 Jun. 2023, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, This 1-year multicenter prospective cohort study aimed to determine the association between observable eating and swallowing function factors and outcomes (death/hospitalization or survival) among elderly persons in long-term care insurance facilities in Japan. Baseline assessments of factors, such as language, drooling, halitosis, hypersalivation, tongue movement, perioral muscle function, coughing, respiration after swallowing, rinsing, and oral residue, among others, were conducted. A score of 0 was considered positive, and a score of 1 or 2 was considered negative. Patient age, sex, body mass index, Barthel index, and Clinical Dementia Rating were recorded. The death/hospitalization or survival rates over 1 year were recorded, and patients were allocated into groups depending on the respective outcome (death/hospitalization group or survival group) and baseline characteristics. A total of 986 residents from 32 facilities were included, with 216 in the death/hospitalization group and 770 in the survival group. Language, salivation, halitosis, perioral muscle, coughing, respiration after swallowing, rinsing, and oral residue were significantly associated with the outcomes (p < 0.05). Therefore, routine performance of these simple assessments by caregivers may allow early detection and treatment to prevent death, pneumonia, aspiration, and malnutrition in elderly persons.

Serum levels of vitamin D and periodontal inflammation in community-dwelling older Japanese adults: The Otassha Study.
Masanori Iwasaki; Keiko Motokawa; Maki Shirobe; Misato Hayakawa; Yuki Ohara; Yoshiko Motohashi; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Yasuyuki Sakata; Kazushige Ihara; Yutaka Watanabe; Shuichi Obuchi; Hirohiko Hirano
Journal of clinical periodontology, 50, 9, 1167, 1175, 15 Jun. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, AIM: To evaluate the association between vitamin D status and periodontal inflammation as determined by the periodontal inflamed surface area (PISA) in community-dwelling older adults. MATERIALS AND METHODS: This cross-sectional study included 467 Japanese adults (mean age = 73.1 years) who underwent full-mouth periodontal examinations and measurements of serum levels of 25-hydroxyvitamin D (25(OH)D). We used linear regression and restricted cubic spline models to analyse the association between exposure (serum 25(OH)D) and outcome (PISA). RESULTS: The linear regression model showed that, after adjusting for potential confounders, participants in the lowest quartile of serum 25(OH)D had 41.0 mm2 more PISA (95% confidence interval [CI]: 4.6-77.5) than the reference group (the highest quartile of serum 25(OH)D). The spline model showed that the association between serum 25(OH)D and PISA was non-linear and restricted to the low 25(OH)D range. PISA initially sharply decreased as serum 25(OH)D increased, and then the decreasing trend slowed and plateaued. The inflection point with the minimum PISA value was a serum 25(OH)D level of 27.1 ng/mL, above which there was no decreasing trend in PISA with increasing serum 25(OH)D levels. CONCLUSIONS: Low vitamin D status had an L-shaped association with periodontal inflammation in this cohort of Japanese adults.

漢方薬が舌痛症と非定型歯痛のみならず種々の全身症状にも奏効した1例
平良 賢周; 新井 絵理; 三浦 和仁; 渡邊 裕; 山崎 裕
痛みと漢方, 32, 92, 98, 日本疼痛漢方研究会, Jun. 2023, [Peer-reviewed]
Japanese

Association between Dementia Severity and Oral Hygiene Management Issues in Older Adults with Alzheimer's Disease: A Cross-Sectional Study.
Maki Shirobe; Ayako Edahiro; Keiko Motokawa; Shiho Morishita; Yuki Ohara; Yoshiko Motohashi; Masanori Iwasaki; Yutaka Watanabe; Hirohiko Hirano
International journal of environmental research and public health, 20, 5, 21 Feb. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, Oral hygiene management issues vary across types and clinical stages of dementia. We aimed to clarify the issues related to oral hygiene management in older adults with Alzheimer's disease (AD) according to stages defined by the Functional Assessment Staging of Alzheimer's Disease (FAST). In all, 397 records (45 men and 352 women; average age, 86.8 years; age range, 65-106) from older adults with AD were used for the cross-sectional study. We used data from a cohort of older adults (≥65 years old) who required long-term care and lived in the Omorimachi area of Yokote City, Akita Prefecture, Japan. Multilevel logistic regression analysis was conducted to examine the associations of the FAST stage, set as the exposure variable, with oral hygiene management parameters set as outcome variables. Compared to the reference category (combined FAST stage 1-3), FAST stages 6 and 7 had significantly higher odds ratios for refusal of oral health care, dependence in performing oral health care, and rinsing and gargling disability. FAST stages 4 and 7 were associated with dental plaque accumulation. Oral health care for older adults with AD should be planned appropriately according to dementia severity.

Severe Periodontitis Increases the Risk of Oral Frailty: A Six-Year Follow-Up Study from Kashiwa Cohort Study.
Misa Nishimoto; Tomoki Tanaka; Hirohiko Hirano; Yutaka Watanabe; Yuki Ohara; Maki Shirobe; Katsuya Iijima
Geriatrics (Basel, Switzerland), 8, 1, 13 Feb. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, Oral frailty, overlapping a decline in multi-faceted oral functions and often seen in older adults, increases risks of adverse health outcomes, thereby necessitating earlier measures. Tooth loss, a major element of oral frailty, is mainly caused by periodontal disease and is an irreversible event. Therefore, this study aimed to clarify whether advanced periodontal disease increases the risks of "new-onset" oral frailty through a longitudinal analysis based on the 2012 baseline survey of the Kashiwa cohort and the follow-up assessments conducted in 2013, 2014, 2016, and 2018. The participants were disability-free, non-orally frail older adults living in Kashiwa City. Of the 1234 participants (72.2 ± 5.1 years old; 50.8% men) analyzed in this study, oral frailty occurred in 23.1% within the six-year period. The group with Community Periodontal Index (CPI) ≥ 3 at baseline had no significant difference in the risk of oral frailty compared with CPI ≤ 2; however, CPI4 at baseline was related to the increased risk of oral frailty compared with CPI ≤ 3 (an adjusted hazard ratio (95% confidence interval): 1.42 (1.12-1.81). Conclusively, severe periodontitis (CPI4) might be associated with new-onset oral frailty, suggesting that prevention of periodontal disease could contribute to oral frailty prevention.

Association between sarcopenia and oral functions in community-dwelling older adults: A cross-sectional study.
Yoshihiro Kugimiya; Masanori Iwasaki; Yuki Ohara; Keiko Motokawa; Ayako Edahiro; Maki Shirobe; Yutaka Watanabe; Yu Taniguchi; Satoshi Seino; Takumi Abe; Shuichi Obuchi; Hisashi Kawai; Takeshi Kera; Yoshinori Fujiwara; Akihiko Kitamura; Kazushige Ihara; Hunkyung Kim; Shoji Shinkai; Hirohiko Hirano
Journal of cachexia, sarcopenia and muscle, 14, 1, 429, 438, Feb. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Few studies have examined the state of oral function in older adults with sarcopenia. We assessed the oral functions of community-dwelling older adults with sarcopenia from multiple perspectives to clarify their potentially low oral function. METHODS: A total of 1517 (86.2%; 990 women, 527 men; mean age 76.1 ± 7.6 years) participants were included in this study. Grip strength, gait speed and skeletal muscle mass index were assessed, and sarcopenia was evaluated according to the criteria of the Asian Working Group for Sarcopenia 2019. The degree of tongue coating, oral moisture, occlusal force, tongue-lip motor function, tongue pressure, masticatory function and swallowing function were assessed. The criteria for oral hypofunction (a disease that is a combination of multiple low oral functions) were used to assess oral function. Statistical analyses were performed using Kolmogorov-Smirnov test, unpaired t-test, Mann-Whitney U test, χ2 test, and univariate and multivariable logistic regression analyses, with each oral function as the dependent variable and sarcopenia as one of the independent variables. The significance level was set at P < 0.05. RESULTS: The prevalence rates of sarcopenia and severe sarcopenia were 14.2% and 3.8%, respectively. The prevalence of oral hypofunction was 39.9%. Compared with the robust group, the sarcopenia and severe sarcopenia groups tended to have a higher frequency of the following components (all P < 0.01): low occlusal force, low tongue-lip motor function, low tongue pressure, low masticatory function, low swallowing function and oral hypofunction. Univariate logistic regression analysis showed that sarcopenia was associated with low occlusal force, low tongue-lip motor function, low tongue pressure, low masticatory function, low swallowing function and oral hypofunction. The odds ratios and 95% confidence intervals of sarcopenia for each oral function were 2.62 [2.00, 3.43], 2.21 [1.69, 2.89], 3.66 [2.79, 4.81], 3.23 [2.46, 4.25], 1.66 [1.26, 2.20] and 3.59 [2.72, 4.72], respectively. Multivariable logistic regression analysis showed that sarcopenia was associated with low occlusal force (1.63 [1.10, 2.40]), low tongue pressure (2.28 [1.65, 3.15]), low masticatory function, (1.94 [1.27, 2.97]), low swallowing function (1.64 [1.17, 2.28]) and oral hypofunction (2.17 [1.52, 3.09]). CONCLUSIONS: This study demonstrated that multiple aspects of oral function were low among community-dwelling older adults with sarcopenia. The potential decline in oral functions in older adults with sarcopenia may have been overlooked until now. This study indicates the need for dental perspectives in intervening with older adults with sarcopenia and the need to encourage them to see dental professionals.

COVID-19-related stress, exercise, and oral health-related quality of life among community-dwelling older adults who participated in the CHEER Iwamizawa project, Japan.
Kazuhito Miura; Yutaka Watanabe; Haruhisa Baba; Kimiya Ozaki; Takae Matsushita; Miyako Kondoh; Kazutaka Okada; Shinji Nakaoka; Katsuhiko Ogasawara; Teppei Suzuki; Hiroshi Saito; Takashi Kimura; Akiko Tamakoshi; Yutaka Yamazaki
Scientific reports, 12, 1, 20347, 20347, 27 Nov. 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, This study examined the association between coronavirus disease 2019 (COVID-19)-related stress, exercise habits, and oral health-related quality of life (OHRQoL) in a sample of 215 community-dwelling older adults in Japan (57 men, 158 women; Mage = 74.2 years, SD = 6.0). Data were collected during wellness checkups in October 2020 and included participants' demographic characteristics, measures of instrumental activities of daily living and depressive tendencies, number of teeth, oral hypofunction, OHRQoL, COVID-19-related stress, and exercise habits. Four mutually exclusive groups were created, using the presence or absence of COVID-19-related stress and lack of exercise habits as risk factors for poor OHRQoL (no COVID-19-related stress and no lack of exercise, COVID-19-related stress only, lack of exercise habits only, and both COVID-19-related stress and lack of exercise habits). Poisson regression with robust standard errors provided the prevalence ratio for poor OHRQoL. The presence of both COVID-19-related stress and lack of exercise habits (adjusted prevalence ratio: 2.20, 95% CI: 1.31- 3.69) was associated with poor OHRQoL. The results indicate that COVID-19-related stress and exercise habits should be considered when designing oral health and public health initiatives.

Impact of number of functional teeth on independence of Japanese older adults.
Kenji Maekawa; Tomoko Ikeuchi; Shoji Shinkai; Hirohiko Hirano; Masahiro Ryu; Katsushi Tamaki; Hirofumi Yatani; Takuo Kuboki; Aya Kimura-Ono; Takeshi Kikutani; Takashi Suganuma; Yasunori Ayukawa; Tomoya Gonda; Toru Ogawa; Masanori Fujisawa; Shoichi Ishigaki; Yutaka Watanabe; Akihiko Kitamura; Yu Taniguchi; Yoshinori Fujiwara; Ayako Edahiro; Yuki Ohara; Junichi Furuya; Junko Nakajima; Kento Umeki; Kentaro Igarashi; Yasuhiro Horibe; Yoshihiro Kugimiya; Yasuhiko Kawai; Hideo Matsumura; Tetsuo Ichikawa; Shuji Ohkawa; Kazuyoshi Baba
Geriatrics & gerontology international, 22, 12, 1032, 1039, 21 Nov. 2022, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: To examine the relationship between the number of present and functional teeth at baseline and future incidence of loss of independence. METHODS: Participants were community-dwelling older individuals who participated in a comprehensive geriatric health examination conducted in Kusatsu town, Japan, between 2009 and 2015. The primary endpoint was the incidence of loss of independence among participants, defined as the first certification of long-term care insurance in Japan. The numbers of present and functional teeth at baseline were determined via an oral examination. Demographics, clinical variables (e.g., history of chronic diseases and psychosocial factors), blood nutritional markers, physical functions, and perceived masticatory function were assessed. RESULTS: This study included 1121 individuals, and 205 individuals suffered from loss of independence during the follow-up period. Kaplan-Meier estimates of loss of independence for participants with smaller numbers of present and functional teeth were significantly greater than for those with larger numbers of teeth. Cox proportional hazard analyses indicated that a smaller number of present teeth was not a significant risk factor after adjusting for demographic characteristics. However, the number of functional teeth was a significant risk factor after the adjustment (hazard ratio: 1.975 [1.168-3.340]). Additionally, higher hazard ratios were observed in other adjusted models, but they were not statistically significant. CONCLUSIONS: The number of functional teeth may be more closely related to the future incidence of loss of independence than the number of present teeth. This novel finding suggests that prosthodontic rehabilitation for tooth loss possibly prevents the future incidence of this life-event. Geriatr Gerontol Int 2022; ••: ••-••.

A novel set of volatile urinary biomarkers for late-life major depressive and anxiety disorders upon the progression of frailty: a pilot study
Akiko Fujita; Kazushige Ihara; Hisashi Kawai; Shuichi Obuchi; Yutaka Watanabe; Hirohiko Hirano; Yoshinori Fujiwara; Yoichi Takeda; Masashi Tanaka; Keiko Kato
Discover Mental Health, 2, 1, 20, 20, Springer Science and Business Media LLC, 27 Oct. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Abstract

Mood and anxiety disorders are frequent in the elderly and increase the risk of frailty. This study aimed to identify novel biomarkers of major depressive disorder (MDD) and anxiety in the elderly. We examined 639 participants in the community-dwelling Otassha Study (518 individuals considered healthy control, 77 with depression, anxiety, etc.), mean age 75 years, 58.4% of female. After exclusion criteria, we analyzed VOCs from 18 individuals (9 healthy control, 9 of MDD/agoraphobia case). Urinary volatile and semi-volatile organic compounds (VOCs) were profiled using solid-phase microextraction and gas chromatography-mass spectrometry. Six urinary VOCs differed in the absolute area of the base peak between participants with MDD and/or agoraphobia and controls. High area under the receiver-operating characteristic curve (AUC) values were found for phenethyl isothiocyanate (AUC: 0.86, p = 0.009), hexanoic acid (AUC: 0.85, p = 0.012), texanol (AUC: 0.99, p = 0.0005), and texanol isomer (AUC: 0.89, p = 0.005). The combined indices of dimethyl sulfone, phenethyl isothiocyanate, and hexanoic acid, and texanol and texanol isomer showed AUCs of 0.91 (p = 0.003) and 0.99 (p = 0.0005) and correlated with the GRID-HAMD and the Kihon Checklist (CL score), respectively. These VOCs may be valuable biomarkers for evaluating MDD and/or agoraphobia in the elderly.

Case of multiple oral complaints related to dentures treated in collaboration with a family dentist
Miura, Kazuhito; Arai, Eri; Ozaki, Kimiya; Kondoh, Miyako; Matsushita, Takae; Okada, Kazutaka; Watanabe, Yutaka; Yamazaki, Yutaka
Hokkaido journal of dental science, 43, 70, 75, 北海道歯学会, 15 Sep. 2022
Japanese, Scientific journal, We report a case of a patient complaining of pain in the oral mucosa, including the tongue. A denturetreatment that caused the pain was treated in cooperation with a family dentist. The patient, a woman in her seventies, had visited a nearby dentist four years before her first visit to our department. After extracting her remaining teeth and the denture adjustment , she became aware of a burning sensation in her palate. Even after the new denture was set, the burning sensation expanded to the maxillary gingiva, tongue, and lips. The metal allergy test was negative, and the patient had to have her dentures repeatedly remade four times by several dentists. During the case, she visited an oral medicine clinic and was diagnosed with oral dysesthesia. She was treated with rikkosan, ethyl loflazepate, and shosaikoto, but only temporary effects were obtained. The burning sensation in the mucosa under the denture base was mild after the denture was remade by a new dentist a year before her first visit to our department. However, the burning pain in her tongue remained. She also complained of xerostomia. Therefore, she was referred by the same dental clinic to our department. At the time of the initial examination, there were no specific findings in her oral cavity. The Cornell Medical Index showed I II regions (suspicion of neurosis), and the Visual Analog Scale for tongue pain was 83. We diagnosed her with burning mouth syndrome. Extensive denture adjustment would have significantly altered the sensation in the mouth, which could have triggered a worsening of the symptoms and interfered with the treatment i n our department. Therefore, we asked the referring dentist to keep the denture adjustments to a minimum and decide d to proceed with the treatment in cooperation with him. In our department’s treatment, cognitive modification by brief psychotherapy and administration of hangekobokuto were concurrently performed. Consequently, the symptoms almost disappeared for a while. However, the symptoms later flared up, and escitalopram treatment was started. Since the symptoms disappeared, the escitalopram dosage was reduced, and the symptoms had not flared up since the end of the medication.

うつ病患者の非定型歯痛に対して半夏厚朴湯が奏効した1例
平良 賢周; 新井 絵理; 三浦 和仁; 渡邊 裕; 山崎 裕
北海道歯学雑誌, 43, 83, 87, 北海道歯学会, Sep. 2022, [Peer-reviewed]
Japanese

Clinical study of risk factors for adherence of Candida to dentures
Kimiya Ozaki; Kazutaka Okada; Takae Matsushita; Miyoko Kondoh; Eri Arai; Kazuhito Miura; Haruhisa Baba; Yutaka Watanabe; Yutaka Yamazaki
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 34, 5, 653, 660, Elsevier BV, Sep. 2022, [Peer-reviewed]
Scientific journal

Association between denture use and food form in older adults requiring long-term care: A multicenter cross-sectional study.
Kenshu Taira; Yutaka Watanabe; Kazutaka Okada; Miyako Kondo; Maaya Takeda; Kayoko Ito; Junko Nakajima; Masanori Iwasaki; Masataka Itoda; Ken Inohara; Rikimaru Sasaki; Yasuhiro Nishi; Junichi Furuya; Yoshihiko Watanabe; George Umemoto; Masako Kishima; Takashi Tohara; Yuji Sato; Mitsuyohi Yoshida; Yutaka Yamazaki
Journal of prosthodontic research, 67, 3, 366, 375, 19 Aug. 2022, [Peer-reviewed], [Corresponding author], [Domestic magazines]
English, Scientific journal, PURPOSE: This study aimed to determine whether denture use contributes to maintaining and improving food forms in long-term care facility (LTCFs) residents. METHODS: In 888 residents of 37 LTCFs in Japan, the following were investigated: nutritional intake status, food forms, age, sex, Barthel index (BI), clinical dementia rating (CDR), number of teeth present, number of occlusal supports, swallowing function, and use of dentures. Among all residents, those who were well-nourished and had ≤9 occlusal supports were analyzed. Based on standardized criteria, the food forms consumed by the subjects were divided into two groups: dysphagia and normal diet, which were further classified into four levels. Analysis was performed using a generalized estimation equation with the four levels of food forms as dependent variables and age, sex, BI, CDR, presence of dysphagia, number of teeth present, and use of dentures as independent variables. RESULTS: The final analysis included 622 (70.0%) residents. Of these, 380 (61.1%) used dentures. The analyses revealed that food form was significantly associated with age (adjusted odds ratio [OR], 0.98), BI (OR, 1.04), number of teeth present (OR, 1.03), presence of dysphagia (OR, 0.44), and use of dentures (OR, 2.82). CONCLUSION: Denture use was associated with food forms among Japanese LTCF residents. This indicates that the use of dentures is related to the maintenance of food forms, even in the elderly who participate in few activities of daily living, have reduced cognitive function, and require long-term care.

A rare case of multiple brain abscesses caused by apical periodontitis of deciduous teeth in congenital heart disease: a case report.
Shizuka Takahashi; Hisato Segoe; Takashi Kikuiri; Yuji Maruo; Tomonobu Sato; Yutaka Watanabe; Zhao Jimei; Yoshitaka Yoshimura; Misa Ishiyama; Atsuhito Takeda; Yasutaka Yawaka; Tetsuo Shirakawa
BMC oral health, 22, 1, 261, 261, 28 Jun. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: A brain abscess is a focal infection in which abscesses form in the brain. A brain abscess is a rare but fatal disease when rupture occurs into the ventricles. We report a case of multiple brain abscesses caused by a hematogenous infection from the apical periodontitis of deciduous teeth. CASE PRESENTATION: The patient was a 7-years and 8-months-old male with congenital heart disease. The patient sought medical attention due to fever and headache, for which he was started on three antibiotics with a diagnosis of multiple brain abscesses. Given that apical periodontitis of deciduous teeth was strongly suspected as the source of the brain abscess, the deciduous teeth were extracted. Immediately after deciduous teeth extraction, the patient's headache and neurological symptoms disappeared. CONCLUSIONS: After teeth extraction, a clear shrinkage of the brain abscess was observed, and the patient was discharged from the hospital.

Factors Predicting Tongue Pressure Decline among Community-Dwelling Older Adults: The Takashimadaira Study.
Chika Takahashi; Masanori Iwasaki; Keiko Motokawa; Yutaka Watanabe; Misato Hayakawa; Yurie Mikami; Maki Shirobe; Hiroki Inagaki; Ayako Edahiro; Yuki Ohara; Hirohiko Hirano; Shoji Shinkai; Shuichi Awata
International journal of environmental research and public health, 19, 13, 26 Jun. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, A limited number of longitudinal studies have explored factors contributing to decreases in tongue pressure (TP). This longitudinal study aimed to clarify the factors affecting TP decline among community-dwelling older adults. We followed the Takashimadaira Study participants with a baseline TP ≥ 30 kPa for 2 years. A TP of <30 kPa at follow-up was defined as TP decline. We used Poisson regression with robust standard errors to explore the factors related to TP decline. The studied baseline variables were dental status, sociodemographic characteristics, health behaviors, appetite, medical conditions, physical function, cognitive status, and anthropometric and body composition characteristics. Inverse probability weighting (IPW) was used to adjust for selection bias. Overall, 357 individuals (159 men and 198 women) with a mean (standard deviation) age of 75.9 (4.1) years were included in the analyses. Of these, 59 study participants (16.5%) exhibited TP decline. After adjusting for baseline TP and applying IPW, poor appetite (incident rate ratio [95% confidence interval] = 1.58 [1.01-2.48]), low skeletal muscle mass index (1.66 [1.02-2.70]), and cognitive impairment (1.93 [1.12-3.33]) were associated with TP decline. In conclusion, we demonstrated that baseline appetite, body composition, and cognitive status could predict future TP decline among community-dwelling older adults.

冷えのぼせを伴う舌痛症患者に漢方薬が奏効した1例
平良 賢周; 新井 絵理; 三浦 和仁; 渡邊 裕; 山崎 裕
痛みと漢方, 31, 40, 45, 日本疼痛漢方研究会, Jun. 2022, [Peer-reviewed]
Japanese

Observational Variables for Considering a Switch from a Normal to a Dysphagia Diet among Older Adults Requiring Long-Term Care: A One-Year Multicenter Longitudinal Study.
Maaya Takeda; Yutaka Watanabe; Takae Matsushita; Kenshu Taira; Kazuhito Miura; Yuki Ohara; Masanori Iwasaki; Kayoko Ito; Junko Nakajima; Yasuyuki Iwasa; Masataka Itoda; Yasuhiro Nishi; Junichi Furuya; Yoshihiko Watanabe; George Umemoto; Masako Kishima; Hirohiko Hirano; Yuji Sato; Mitsuyoshi Yoshida; Yutaka Yamazaki
International journal of environmental research and public health, 19, 11, 28 May 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, This one-year multicenter longitudinal study aimed to assess whether older adult residents of long-term care facilities should switch from a normal to a dysphagia diet. Using the results of our previous cross-sectional study as baseline, older adults were subdivided into those who maintained a normal diet and those who switched to a dysphagia diet. The explanatory variables were age, sex, body mass index (BMI), Barthel Index, clinical dementia rating (CDR), and 13 simple and 5 objective oral assessments (remaining teeth, functional teeth, oral diadochokinesis, modified water swallowing test, and repetitive saliva swallowing test), which were used in binomial logistic regression analysis. Between-group comparison showed a significantly different BMI, Barthel Index, and CDR. Significant differences were also observed in simple assessments for language, drooling, tongue movement, perioral muscle function, and rinsing and in objective assessments. In multi-level analysis, switching from a normal to a dysphagia diet was significantly associated with simple assessments of tongue movement, perioral muscle function, and rinsing and with the objective assessment of the number of functional teeth. The results suggest that simple assessments can be performed regularly to screen for early signs of discrepancies between food form and eating/swallowing functions, which could lead to the provision of more appropriate food forms.

Standard Values and Concurrent Validity of a Newly Developed Occlusal Force-Measuring Device among Community-Dwelling Older Adults: The Otassha Study.
Masanori Iwasaki; Ichinosuke Maeda; Yota Kokubo; Yoshitomo Tanaka; Tetsuji Ueno; Yuki Ohara; Keiko Motokawa; Misato Hayakawa; Maki Shirobe; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Yutaka Watanabe; Shuichi Obuchi; Hirohiko Hirano
International journal of environmental research and public health, 19, 9, 04 May 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Recently, an occlusal force-measuring device with a capacitive-type pressure-mapping sensor (OFMD-CPS) was developed. We aimed to establish age- and sex-specific standard values for OFMD-CPS-measured occlusal force (OF) and to assess the concurrent validity of the OFMD against another OF measuring system with a pressure-sensitive sheet (Dental Prescale II). Using data from a population-based study, we calculated the OFMD-CPS-measured OF means and deciles in 5-year age groups for each sex. The OFMD-CPS-measured OF was validated against the Dental Prescale II-measured OF with Spearman correlation coefficients. Furthermore, we calculated the area under the receiver operating characteristic curve (AUC) against the preexisting Dental Prescale II-measured OF cutoff value of 350 N. In total, 596 individuals (236 men and 360 women) with a mean (standard deviation (SD)) age of 73.7 (6.7) years were included in the analyses. The mean (SD) OFMD-CPS-measured OFs were 581.6 (284.6) N in men and 446.9 (209.9) N in women. There was a strong positive correlation (Spearman's Rho = 0.73) between OFMD-CPS-measured and Dental Prescale II-measured OF. The diagnostic accuracy of the OFMD-CPS-measured OF for the Dental Prescale II-measured OF cutoff value was high (AUC = 0.88). In conclusion, we demonstrated standard values and concurrent validity of OFMD-CPS-measured OF in community-dwelling older adults.

A Cross-Sectional Study on the Relationship between Oral Function and Sarcopenia in Japanese Patients with Regular Dental Maintenance.
Ryuichi Shirahase; Yutaka Watanabe; Tohru Saito; Yusuke Sunakawa; Yuya Matsushita; Hideki Tsugayasu; Yutaka Yamazaki
International journal of environmental research and public health, 19, 9, 24 Apr. 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, We aimed to clarify the relationship between oral function assessments regarding oral hypofunction and sarcopenia in patients who had completed treatment for organic dental problems, including oral pain, removable denture fit, and tooth loss. This cross-sectional study included 269 patients aged ≥65 years (mean age 74.9 ± 6.50 years, 133 men, 136 women) who visited a dental clinic between June 2019 and March 2021. We evaluated oral function and sarcopenia and analyzed their relationship using the Jonckheere-Terpstra test, Mantel-Haenszel trend test, and Poisson regression analysis. We diagnosed 132 (49.07%) patients with oral hypofunction, 30 (11.2%) with sarcopenia, and 24 (8.9%) with severe sarcopenia. The number of oral hypofunction items (prevalence rate ratio [PRR] = 1.39, 95%Wald = 0.11 to 0.56) was significantly associated with sarcopenia. For each of the items, tongue-lip motor function [ta] (PRR = 0.80, 95%Wald = -0.44 to -0.02)] [ka] (PRR = 0.76, 95%Wald = -0.53 to -0.03) and tongue pressure (PRR = 0.95, 95%Wald = -0.09 to -0.02) showed a significant association with sarcopenia. However, no significant association was found for other variables. Dentists should not only treat organic dental problems but also consider the relationship between oral function and sarcopenia.

Factors Associated with Food Form in Long-Term Care Insurance Facilities.
Maaya Takeda; Kazutaka Okada; Miyako Kondo; Kenshu Taira; Yutaka Watanabe; Kayoko Ito; Junko Nakajima; Yoshie Ozaki; Rikimaru Sasaki; Yasuhiro Nishi; Junichi Furuya; Kenichi Akino; Hiromi Ohta; Tomohisa Ohno; Tsuyoshi Kodama; Hideo Sakaguchi; Tetsuo Hanagata; Yuji Sato; Mitsuyoshi Yoshida; Yutaka Yamazaki
Dysphagia, 37, 6, 1757, 1768, 12 Apr. 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, We examined factors related to dietary intake status (food form) of long-term care facility (LTCF) residents to identify factors related to proper food form choice for older individuals requiring nursing care. We surveyed 888 residents from 37 LTCFs in Japan. We evaluated basic information (age, sex, body mass index [BMI]), food form (swallowing-adjusted diet class), Barthel Index (BI), Clinical Dementia Rating (CDR), simply evaluated eating and swallowing functions, the number of present/functional teeth, oral diadochokinesis, repetitive saliva swallowing test (RSST), and modified water swallowing test. To clarify factors associated with food form, participants who had good nutrition by oral intake were categorized into the dysphagic diet (DD) and normal diet (ND) groups. Multi-level analyses were used to detect oral functions associated with food form status. Among objective assessments, BMI (odds ratio [OR] 0.979, 95% confidence interval [CI] - 0.022- to 0.006, p = 0.001), BI (OR 0.993, 95% CI - 0.007 to - 0.004, p < 0.001), CDR 3.0 (OR 1.002, 95% CI 0.002‒0.236, p = 0.046), present teeth (OR 0.993, 95% CI - 0.007 to - 0.001, p = 0.011), functional teeth (OR 0.989, 95% CI - 0.011 to - 0.005, p < 0.001), and RSST (OR 0.960, 95% CI - 0.041 to - 0.007, p = 0.006) were significantly associated with DD vs ND discrimination. Simple evaluations of coughing (OR 1.056, 0.054‒0.198, p = 0.001) and rinsing (OR 1.010, 0.010‒0.174, p = 0.029) could also discriminate food form status. These simple evaluations provide insight into the discrepancies between food form status and eating abilities of LTCF residents. Periodic evaluations by the nursing caregiver may help to prevent aspiration by older individuals with dysphagia.

The relationship of falling in non-diabetic, prediabetic, and diabetic community-dwelling older people, and changes in their physical functioning
KERA Takeshi; KAWAI Hisashi; EJIRI Manami; HIRANO Hirohiko; WATANABE Yutaka; FUJIWARA Yoshinori; KIM Hunkyung; IHARA Kazushige; OBUCHI Shuichi
Journal of Physical Therapy for Prevention, 1, 3, 9, Japanese Society of physical therapy for prevention, 31 Mar. 2022, [Peer-reviewed]
Japanese, Objective: This longitudinal study aimed to evaluate the risk of falls in non-diabetic, prediabetic, and diabetic community-dwelling older people, together with the characteristics of physical functioning in these groups.

Methods: This study enrolled 541 community-dwelling older adults who participated in our cohort study and whose HbA1c (Hemoglobin A1c) levels, body composition, cognitive function, and physical function had been assessed. Previous fall histories were recorded at baseline and subsequently at a 3-year follow-up. Participants were divided into non-diabetic, prediabetic, and diabetic groups, based on both baseline HbA1c levels and selfreport. Falls experienced during the study period were evaluated using the adjusted Cox proportional hazard analysis. In addition, the physical functioning of the study participants with and without diabetes were compared, both with those who experienced falls during the study period, and with those who had not.

Results: The incidence rate of falls was 18.8 %, 17.1 %, and 31.6 % in the non-diabetes, prediabetes, and diabetes groups, respectively. The Cox proportional hazard analysis showed that falls were associated with diagnosed diabetes (hazard ratio: 2.99, 95 % confidence interval: 1.52-5.88) but not with prediabetes. The one-leg standing time in fallers was worse in the diabetic group and decreased fastest among these individuals per year.

Conclusions: Implementing countermeasures for decreasing balance function are important to prevent falls in community-dwelling older people with diabetes.

フレイルおよび認知症と口腔健康の関係に焦点化した人生100年時代を見据えた歯科治療指針作成に関する研究
平野 浩彦; 佐藤 裕二; 飯島 勝矢; 小玉 剛; 古屋 純一; 上田 貴之; 恒石 美登里; 渡邊 裕; 岩崎 正則; 小原 由紀; 枝広 あや子
日本歯科医学会誌, 41, 27, 31, 日本歯科医学会, Mar. 2022
Japanese

フレイルおよび認知症と口腔健康の関係に焦点化した人生100年時代を見据えた歯科治療指針作成に関する研究
平野 浩彦; 佐藤 裕二; 飯島 勝矢; 小玉 剛; 古屋 純一; 上田 貴之; 恒石 美登里; 渡邊 裕; 岩崎 正則; 小原 由紀; 枝広 あや子
日本歯科医学会誌, 41, 27, 31, 日本歯科医学会, Mar. 2022, [Peer-reviewed], [Invited]
Japanese

歯科訪問診療における感染予防策の指針 2022年版
水口 俊介; 佐藤 裕二; 小玉 剛; 猪原 光; 小原 由紀; 金久 弥生; 菊谷 武; 菅 武雄; 花形 哲夫; 米山 武義; 渡邊 裕; 渡部 芳彦; 古屋 純一; 吉田 光由; 猪原 健; 河野 雅臣; 佐藤 繭美; 宮本 雄気; 高木 理史; 一般社団法人日本老年歯科医学会, 一般社団法人日本老年歯科医学会在宅歯科医療委員会, 一般社団法人日本在宅医療連合学会
老年歯科医学, 36, 4, E76, E108, (一社)日本老年歯科医学会, Mar. 2022, [Peer-reviewed], [Invited]
Japanese

Oral frailty and carriage of oral Candida in community-dwelling older adults (Check-up to discover Health with Energy for senior Residents in Iwamizawa; CHEER Iwamizawa).
Haruhisa Baba; Yutaka Watanabe; Kazuhito Miura; Kimiya Ozaki; Takae Matsushita; Miyako Kondoh; Kazutaka Okada; Akira Hasebe; Tokiyoshi Ayabe; Kiminori Nakamura; Shinji Nakaoka; Katsuhiko Ogasawara; Teppei Suzuki; Hiroshi Saito; Takashi Kimura; Akiko Tamakoshi; Yutaka Yamazaki
Gerodontology, 39, 1, 49, 58, Mar. 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, OBJECTIVE: To examine the association between oral frailty and oral Candida carriage as a general indicator of deteriorating oral function in older adults. BACKGROUND: Older adults exhibit an elevated risk of oral candidiasis caused by Candida. Although many studies have identified factors associated with oral Candida carriage, none have evaluated its relationship with oral function. MATERIALS AND METHODS: This study included 210 community-dwelling older adults aged ≥60 years who participated in wellness checks. Fungal flora expression in saliva samples was evaluated to identify oral C. albicans and C. glabrata. Participants were categorised by detection of neither strain (group 1), either one of the strains (group 2), or both strains (group 3). The relationship between oral Candida carriage and oral frailty was evaluated by multinomial logistic regression analysis. RESULTS: The participants included 58 men and 152 women with a mean age of 74.2 ± 6.1 years. A total of 88 (41.9%), 94 (44.8%) and 28 (13.3%) participants were assigned to groups 1, 2 and 3 respectively. In the multinomial logistic regression analysis, significant associations were observed between group 1 and group 2 for "Have you choked on your tea or soup recently?" and the number of applicable oral frailty items. Between group 1 and group 3, significant associations were observed for the number of remaining teeth, masticatory performance and the number of applicable oral frailty items. CONCLUSION: We obtained basic data useful for intervention studies aimed at verifying whether oral function management prevents deterioration of the oral bacterial flora.

Development of a screening formula for sarcopenia using ground reaction force during sit-to-stand motion.
Takeshi Kera; Hisashi Kawai; Junta Takahashi; Hirohiko Hirano; Yutaka Watanabe; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Shuichi Obuchi
Gait & posture, 93, 177, 182, 03 Feb. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Ground reaction force during sit-to-stand motion is related to lower extremity strength, and such measurements indicating weak muscle strength, may be linked to sarcopenia. We aimed to examine and describe the relationship between sarcopenia and ground reaction force during sit-to-stand motion to develop a diagnostic tool. RESEARCH QUESTION: Can ground reaction force during sit-to-stand motion help detect sarcopenia? METHODS: This study included 627 community-dwelling older adults who were divided into non-sarcopenia and sarcopenia groups to compare ground reaction force parameters. A sit-to-stand force analyzer was used to measure the ground reaction force, power, and time between the minimum and maximum ground reaction force. We assessed the association between sarcopenia and each ground reaction force parameter. Receiver operating characteristic curve analysis was performed with sarcopenia as the dependent variable and ground reaction force-related measurements as independent variables. The probability of predicting sarcopenia was calculated using multiple logistic regression analysis, with sex and age as independent variables, and another receiver operating characteristic analysis was performed using the probability value. RESULTS: Ground reaction force parameters related to strength and power were lower in the sarcopenia group than in the non-sarcopenia group. Furthermore, we were able to develop a formula to detect sarcopenia using the maximum ground reaction force (area under the curve; 0.906 [95% CI 0.858-0.954] for men and 0.858 [0.808-0.908] for women). The sensitivity and specificity of sarcopenia detection using this formula were 89.7% and 80.5%, respectively, for men and 95.0% and 60.9%, respectively, for women. SIGNIFICANCE: Ground reaction force during sit-to-stand motion may reflect low skeletal muscle strength associated with sarcopenia. We were able to develop a method for sarcopenia detection by analyzing the sit-to-stand force required in only one or two sit-to-stand motions, even though it does not measure the skeletal muscle mass directly.

Population-based reference values for tongue pressure in Japanese older adults: A pooled analysis of over 5,000 participants.
Masanori Iwasaki; Yuki Ohara; Keiko Motokawa; Misato Hayakawa; Maki Shirobe; Ayako Edahiro; Yutaka Watanabe; Shuichi Awata; Tsuyoshi Okamura; Hiroki Inagaki; Naoko Sakuma; Shuichi Obuchi; Hisashi Kawai; Manami Ejiri; Kumiko Ito; Yoshinori Fujiwara; Akihiko Kitamura; Yu Nofuji; Takumi Abe; Katsuya Iijima; Tomoki Tanaka; Bo-Kyung Son; Shoji Shinkai; Hirohiko Hirano
Journal of prosthodontic research, 67, 1, 62, 69, 27 Jan. 2022, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: To establish age- and sex-specific population reference values for tongue pressure (TP) in community-dwelling Japanese older adults. METHODS: For this analysis, we pooled four population-based studies on community-dwelling adults aged ≥65 years that measured TP using a JMS tongue pressure measuring device. We calculated the means and deciles of TP per 5-year age group for each sex. We also estimated age trends in TP for men and women. RESULTS: In total, 5,083 individuals (2,150 men and 2,933 women, with a mean [standard deviation] age of 75.2 [6.5] years) were included in the present analysis. In male participants, the mean (standard deviation) TPs for ages 65-69, 70-74, 75-79, 80-84, and ≥85 years were 34.0 (8.4), 32.2 (8.1), 30.8 (8.3), 28.4 (8.9), and 24.4 (8.2) kPa, respectively. In female participants, the corresponding values were 31.5 (7.1), 30.5 (7.5), 29.6 (7.3), 28.4 (8.0), and 26.4 (7.6) kPa, respectively. For both sexes, there were significant declining trends in TP with advanced age. In addition, the interaction between age and sex had a significant effect on TP (regression coefficient [95% confidence interval] = -0.18 [-0.25 to -0.11] when age was modeled as a continuous variable and sex was modeled as a categorical variable [coded as 0=women, 1=men]). CONCLUSION: This study determined age- and sex-specific reference values for TP, presented as means and deciles, in community-dwelling Japanese older adults aged ≥65 years. This study also demonstrated sex differences in age-related declines in TP.

Capacitive-Type Pressure-Mapping Sensor for Measuring Bite Force.
Masanori Iwasaki; Ichinosuke Maeda; Yota Kokubo; Yoshitomo Tanaka; Tetsuji Ueno; Wataru Takahashi; Yutaka Watanabe; Hirohiko Hirano
International journal of environmental research and public health, 19, 3, 24 Jan. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Bite force is an important indicator of masticatory performance. However, existing methods for measuring bite force are either ineffective or expensive. Hence, we developed a novel capacitive-type pressure-mapping sensor that converts mechanical forces into changes in capacitance and calculates bite force. A portable device was fabricated based on this sensor sheet, and the accuracy of the bite-force measurements provided by the device was evaluated. The sensor has a thickness of 1.6 mm and has 63 measurement points. It was inserted into a dental model, where the output value was measured and compared with that of a universal testing machine (AG-IS 100 kN). A regression equation to estimate the bite force was obtained based on the relationship between the output of the capacitive-type pressure-mapping sensor and that of the load cell of the universal testing machine. The estimated bite force from the sensor and the quadratic regression equation closely resembled the known load applied by the compression tester (R2 = 0.992). We therefore conclude that the developed sensor can measure bite force accurately and effectively. A device with a built-in capacitive-type pressure-mapping sensor can potentially be a user-friendly tool for bite-force measurements in both clinical and epidemiological settings.

Association of prediabetes with retinal microvasculature on swept-source optical coherence tomography angiography in the elderly: OTASSHA study.
You Wang; Taku Toyama; Yohei Hashimoto; Hisashi Kawai; Kunihiro Azuma; Tomoyasu Shiraya; Satoshi Kato; Yutaka Watanabe; Hirohiko Hirano; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Jiro Numaga; Shuichi Obuchi; Takashi Ueta
Retina (Philadelphia, Pa.), 42, 6, 1130, 1136, 20 Jan. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, AIMS: To investigate the retinal microvasculature in the elderly persons with prediabetes mellitus (preDM) and type 2 DM. METHODS: This cross-sectional study included a total of 452 eyes without retinal pathologies of 301 elderly volunteers aged ≥65 years, and they were categorized into nonDM (225 eyes), preDM (177 eyes), and DM (50 eyes) groups based on their HbA1c. Fundus photography, swept-source optical coherence tomography and angiography, and comprehensive systemic examinations were conducted. Vessel density (VD) and foveal avascular zone (FAZ) in superficial and deep retinal microvasculature were investigated for their association with DM stages using linear mixed model. RESULTS: Superficial VD (sVD) mean values in nonDM, preDM, and DM groups were 35.2, 34.9, and 34.8%, respectively. sVD in preDM was equivalent to sVD in DM, while significantly lower compared with sVD in nonDM (difference[95%CI] -0.19[-0.33 - -0.049], P=0.009). Deep VD (dVD) mean values in nonDM, preDM, and DM groups were 35.0, 35.0, 34.4%, respectively. dVD in preDM was equivalent to dVD in nonDM, while significantly higher compared with dVD in DM (difference[95%CI] 0.31[0.046-0.57], P=0.02). There was no significant association between FAZ area and DM stages. CONCLUSIONS: Retinal microvasculature might be affected at the prediabetic stage in the elderly.

Relationship between Eating Alone and Poor Appetite Using the Simplified Nutritional Appetite Questionnaire.
Yurie Mikami; Keiko Motokawa; Maki Shirobe; Ayako Edahiro; Yuki Ohara; Masanori Iwasaki; Misato Hayakawa; Yutaka Watanabe; Hiroki Inagaki; Hunkyung Kim; Shoji Shinkai; Shuichi Awata; Hirohiko Hirano
Nutrients, 14, 2, 14 Jan. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, One prominent factor associated with malnutrition is poor appetite. In Japan, the number of older adults living alone has increased annually. Those living alone tended to eat alone, which may lead to poor appetite. This study aimed to investigate the association between eating alone and poor appetite using an index called the Simplified Nutritional Appetite Questionnaire (SNAQ). We surveyed 818 people aged 70 and over in Takashimadaira, Itabashi-ku, Tokyo, Japan, in 2016. Comparisons were made between two groups, a poor appetite group (n = 295) and a good appetite group (n = 523), and results indicate that the poor appetite group had a higher rate of eating alone than the good appetite group (38.0% vs. 20. 1%: p < 0.001). Multivariable logistic regression (OR; 95%CI) was performed and poor appetite was significantly associated with the Geriatric Depression Scale (GDS) score (1.707; 1.200-2.427), the number of medications (1.061; 1.007-1.118), JST score (0.894; 0.841-0.950), the indication of "very healthy" on a self-rated health scale (0.343; 0.152-0.774), and reports of eating alone (1.751; 1.130-2.712). Our results suggest that eating alone is associated with a poor appetite.

Determinants of new participation in sports groups among community-dwelling older adults: Analysis of a prospective cohort from The Otassha Study.
Manami Ejiri; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Yutaka Watanabe; Hirohiko Hirano; Hunkyung Kim; Shuichi Obuchi
PloS one, 17, 10, e0275581, 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Participation in sports groups has health benefits for older adults, such as preventing functional limitations and social isolation. Encouraging participation in sports groups may be an important means of health promotion in older adults. However, there is insufficient research on the determinants of new participation in sports groups to consider effective interventions to promote participation in these groups. We investigated this using data from a 1-year prospective study. Data were obtained from "The Otassha Study" that assessed a cohort of community-dwelling older adults living in an urban area of Japan. Of 769 older adults who participated in a baseline health survey in 2018, 557 participated in a follow-up survey in 2019. We excluded 184 individuals who already participated in sports groups at baseline and 36 with missing data. Participation in sports groups was defined as that occurring more than once a week. Logistic regression analysis was used to identify the determinants of new participation in sports groups, with sociodemographic factors, lifestyle habits, physical functions, cognitive functions, psychological factors, and social factors as independent variables. Forty-one (12.2%) individuals participated in sports groups at follow-up. In the multiple adjusted logistic regression model, new participation in sports groups was significantly associated with female sex (odds ratio [OR] = 5.57, 95% confidence interval [CI]: 1.61‒19.26), engagement in regular exercise (OR = 2.23, 95%CI: 1.03‒4.84), and having a large social network (OR = 1.12, 95%CI: 1.04‒1.20). Physical functions were not associated with new participation. Determinants of new participation were lifestyle habits and social factors, rather than physical functions. Intervention through social networks may be effective in encouraging new participation in sports groups, which, in turn, may facilitate healthy aging.

Normative Data of the Trail Making Test Among Urban Community-Dwelling Older Adults in Japan.
Hiroyuki Suzuki; Naoko Sakuma; Momoko Kobayashi; Susumu Ogawa; Hiroki Inagaki; Ayako Edahiro; Chiaki Ura; Mika Sugiyama; Fumiko Miyamae; Yutaka Watanabe; Shoji Shinkai; Shuichi Awata
Frontiers in aging neuroscience, 14, 832158, 832158, 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Introduction: Population aging is likely to increase the number of people with dementia living in urban areas. The Trail Making Test (TMT) is widely used as a cognitive task to measure attention and executive function among older adults. Normative data from a sample of community-dwelling older adults are required to evaluate the executive function of this population. The purpose of this study was to examine the Trail Making Test completion rate and completion time among urban community-dwelling older adults in Japan. Methods: A survey was conducted at a local venue or during a home visit (n = 1,966). Cognitive tests were conducted as a part of the survey, and TMT Parts A (TMT-A) and B (TMT-B) were completed after the completion of the Japanese version of the Mini-Mental State Examination (MMSE-J). Testers recorded TMT completion status, completion time, and the number of errors observed. Results: In the TMT-A, 1,913 (99.5%) participants understood the instructions, and 1,904 (99.1%) participants completed the task within the time limit of 240 s. In the TMT-B, 1,839 (95.9%) participants understood the instructions, and 1,584 (82.6%) participants completed the task within the time limit of 300 s. The completion rate of TMT-B was 90.2 and 41.8% for participants with an MMSE-J score of >23 points and ≦23 points, respectively. Results of multiple regression analyses showed that age, education, and the MMSE-J score were associated with completion time in both TMTs. Conclusion: In both TMTs, completion time was associated with age, education, and general cognitive function. However, not all participants completed the TMT-B, and the completion rate was relatively low among participants with low MMSE-J scores. These findings may help interpret future TMT assessments.

Cognitive function, daily function and physical and mental health in older adults: A comparison of venue and home-visit community surveys in Metropolitan Tokyo.
Naoko Sakuma; Hiroki Inagaki; Madoka Ogawa; Ayako Edahiro; Chiaki Ura; Mika Sugiyama; Fumiko Miyamae; Hiroyuki Suzuki; Yutaka Watanabe; Shoji Shinkai; Tsuyoshi Okamura; Shuichi Awata
Archives of gerontology and geriatrics, 100, 104617, 104617, 28 Dec. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: We conducted surveys in older people at a venue and in home-visits, and compared cognitive and health status between the two groups to assess their cognitive and everyday functioning. METHODS: Among 7,614 persons aged 70 years and older living in an urban area, 5,430 responded to a mail survey for sociodemographic characteristics and self-rated questionnaires including the Geriatric Depression Scale-short form (GDS-15). Of these, 1,360 agreed to attend a venue survey, and 693 agreed to take a home-visit survey. Trained nurses examined participants' blood pressure, medical history, and daily functions using the dementia assessment sheet for community-based integrated care system (DASC-21), and tested their cognitive function using the Mini-Mental State Examination (MMSE). RESULTS: Of 2,053 participants, 2,020 (venue: 1,352; home-visit: 668) completed the MMSE. Median MMSE scores for the venue and home-visit groups were 28 and 26 points, respectively, with 130/1,352 (9.6%) and 205/668 (30.7%) participants below the traditional 23/24 cutoff score. The home-visit group had lower mobility, lower frequency of going out, poorer mental health, and lower independence in instrumental daily activities. Notably, 39.9% and 43.7% of the venue and home-visit groups lived alone, respectively. CONCLUSIONS: In this sample of urban older people, the rate of cognitive decline detected using the MMSE was three times higher in the home-visit group than in the venue group. Home-visit participants were more likely to have difficulty in physical, cognitive, and everyday functioning, suggesting they have a greater need for daily living support to continue living in the community.

Xerostomia as a key predictor of physical frailty among community-dwelling older adults in Japan: a five-year prospective cohort study from The Otassha Study.
Yuki Ohara; Masahori Iwasaki; Maki Shirobe; Hisashi Kawai; Ayako Edahiro; Keiko Motokawa; Yoshinori Fujiwara; Hunkyung Kim; Kazushige Ihara; Shuichi Obuchi; Yutaka Watanabe; Hirohiko Hirano
Archives of gerontology and geriatrics, 99, 104608, 104608, 09 Dec. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To the best of our knowledge, the association between xerostomia and physical frailty has not been studied in Asian countries. This prospective cohort study aimed to investigate the longitudinal association between xerostomia and the incidence of physical frailty in Japan. METHODS: This study included community-dwelling older adults aged ≥65 years at baseline (n=609). Baseline intraoral examination, physical performance and anthropometric measurements, blood examination, a structured self-administered questionnaire survey, and face-to-face interviews were conducted. Xerostomia was defined using a dichotomous questionnaire. Following the baseline survey, data on the incidence of physical frailty were collected over 5 years. Physical frailty, the outcome variable, was defined as weakness, slowness, weight loss, low physical activity level, and exhaustion. Participants with three or more components were considered frail. The hazard ratio (HR) for physical frailty incidence according to xerostomia was calculated using Cox hazards regression analysis. RESULTS: At baseline, 166 participants (27.3 %) complained of xerostomia. During follow-up, 109 participants (17.9 %) developed physical frailty. After adjusting for confounding factors, such as sex, age, educational level, polypharmacy, comorbidities, and smoking habit, xerostomia was significantly associated with the incidence of physical frailty (adjusted HR 1.65; 95 % confidence interval [CI] 1.09-2.52). CONCLUSIONS: Xerostomia is one of the key predictors of physical frailty. Our results suggested that assessing and preventing xerostomia is important for preventing physical frailty.

COVID-19の影響で発症したと思われる心因性味覚障害の1例
平良 賢周; 新井 絵理; 三浦 和仁; 稲本 香織; 中川 紗百合; 渡邊 裕; 山崎 裕
日本歯科心身医学会雑誌, 36, 1-2, 28, 32, (一社)日本歯科心身医学会, Dec. 2021
Japanese, コロナ禍で仕事が激減し自宅待機になった頃から舌痛と味覚異常を自覚した患者に対してロフラゼプ酸エチルを投与したところ著効した症例を経験した。症例は60代男性で、味覚異常がCOVID-19によるものなのか否かの鑑別を要した。COVID-19による味覚異常の場合には突然発症することが多いとされ、また、ある疫学調査によると味覚異常出現後に症状が完全に回復するまでの期間は中央値15日と報告されている。本例では先ず舌痛が出現し、その約3ヵ月後から味覚異常を徐々に自覚し、味覚異常が出現してから当科受診までに2ヵ月が経過しており、その間に全身症状は全くなく、舌痛と味覚異常が改善する傾向もみられなかった。これらより味覚異常はCOVID-19による症状ではなく心因性と判断し、PCR検査は施行しなかった。

Association between dry mouth and physical frailty among community-dwelling older adults in Japan: The Otassha Study.
Yuki Ohara; Hisashi Kawai; Maki Shirobe; Masanori Iwasaki; Keiko Motokawa; Ayako Edahiro; Hunkyung Kim; Yoshinori Fujiwara; Kazuhige Ihara; Yutaka Watanabe; Shuichi Obuchi; Hirohiko Hirano
Gerodontology, 39, 1, 41, 48, 11 Nov. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To elucidate the relationship between physical frailty and dry mouth among community-dwelling older adults in Japan. BACKGROUND: Oral hypofunction is associated with physical frailty in older adults. Dry mouth, subjectively evaluated as xerostomia and objectively measured as hyposalivation, is highly prevalent in older adults. However, few reports have used both measures of dry mouth and investigated their association with physical frailty. MATERIALS AND METHODS: This cross-sectional study included 643 individuals (mean age, 73.9 years) from the Otassha Study in 2019. Xerostomia was assessed using the 5-item Summated Xerostomia Inventory (SXI). Hyposalivation was assessed by measuring the amount of resting saliva using the modified cotton roll method. Frailty phenotypes were defined by weakness, slowness, weight loss, low physical activity level and exhaustion components, and served as the outcome variable. Participants with three or more components were considered physically frail, and those with one or two components were considered pre-frail. Ordinal logistic regression analyses were performed to evaluate the associations between physical frailty and xerostomia and hyposalivation. RESULTS: Among the participants, 4.5% and 49.8% had physical frailty and pre-frailty, respectively. In ordinal logistic regression analysis adjusted for demographic and health characteristics, the SXI score was associated with physical frailty status (adjusted odds ratio for a one-point increase in SXI, 1.12; 95% confidence interval, 1.06-1.19). However, no difference was observed between the amount of resting saliva and severity of physical frailty. CONCLUSION: Xerostomia is associated with physical frailty among community-dwelling older adults in Japan. CLINICAL TRIAL REGISTRATION: Not applicable.

Pneumonia incidence and oral health management by dental hygienists in long-term care facilities: A 1-year prospective multicentre cohort study.
Kaoko Hama; Yasuyuki Iwasa; Yuki Ohara; Masanori Iwasaki; Kayoko Ito; Junko Nakajima; Takae Matsushita; Takashi Tohara; Mayumi Sakamoto; Masataka Itoda; Ken Inohara; Yoshie Ozaki; Rikimaru Sasaki; Yasuhiro Nishi; Midori Tsuneishi; Junichi Furuya; Yutaka Watanabe; Yoshihiko Watanabe; Yuji Sato; Mitsuyoshi Yoshida
Gerodontology, 09 Nov. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To investigate the association between oral health management (OHM) by dental hygienists and the occurrence of pneumonia, and determine the effectiveness of OHM in pneumonia prevention. BACKGROUND: In long-term care facilities in Japan, the need for professional OHM is increasing with an increase in the number of severely debilitated residents. MATERIALS AND METHODS: A 1-year prospective multicentre cohort study was conducted using data from 504 residents (63 men; mean age: 87.4 ± 7.8 years) in Japanese long-term care facilities. Basic information, medical history, willingness to engage in oral hygiene behaviour, need for OHM and oral conditions were investigated at baseline. In addition, information on the occurrence of pneumonia was collected using a follow-up survey after one year. A Poisson regression analysis with robust standard errors was conducted, with pneumonia as the dependent variable, and factors associated with OHM and pneumonia occurrence as explanatory variables. RESULTS: Overall, 349 (69.2%) residents required OHM by dental hygienists during that year of follow-up. Of those, 238 (68.2%) were provided with OHM, and 18 (7.5%) developed pneumonia. Among the 111 patients (31.8%) who were not provided with OHM, 21 (18.9%) developed pneumonia. The OHM group had lower pneumonia rates than the non-OHM group (prevalence rate ratio: 0.388; 95% CI: 0.217-0.694). CONCLUSION: Oral health management by dental hygienists was associated with a lower incidence of pneumonia among residents of long-term care facilities, underlining the importance of professional OHM for such individuals. It is recommended that OHM be practised routinely in long-term care facilities.

Exercise as a coping strategy and its impact on the psychological well-being of Japanese community-dwelling older adults during the COVID-19 pandemic: A longitudinal study.
Manami Ejiri; Hisashi Kawai; Takeshi Kera; Kazushige Ihara; Yoshinori Fujiwara; Yutaka Watanabe; Hirohiko Hirano; Hunkyung Kim; Shuichi Obuchi
Psychology of sport and exercise, 57, 102054, 102054, Nov. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, This study aimed to examine the prevalence of exercise as a coping strategy among Japanese community-dwelling older adults and its impact on their psychological well-being during the COVID-19 pandemic. In October 2019 (baseline [BL]), 720 community-dwelling older adults living in an urban area in Japan participated in a comprehensive health survey. Of these, 618 responded to a mail survey (follow-up [FL]) in June 2020, after the first state of emergency was lifted. Their psychological well-being was assessed using the WHO-5 Well-Being Index (WHO-5). Exercise as a coping strategy during the stay-at-home period was determined at FL by asking respondents whether they had engaged in 1) walking and 2) at-home exercise and strength training to maintain their physical and mental health. Each type of exercise's impact and the effective exercise combinations were examined. Time and group interaction effects on the WHO-5 scores were investigated using a two-way analysis of covariance. Of the final sample, 65.1% engaged in walking. The WHO-5 mean scores at BL and FL were 16.7 and 15.4 for the walking group and 16.7 and 14.5 for the non-walking group, respectively; interaction for time and group was significant. Additionally, 56.4% of the participants engaged home training. The WHO-5 mean score at BL and FL were 17.5 and 15.5 for the home training group and 15.7 and 14.5 for the no home training group, respectively; there was no significant interaction. Older adults who engaged in both walking and home training received higher score on the WHO-5 than those who engaged in only one activity at FL. The decline in psychological well-being was most attenuated in the walking only group compared to the at-home exercise and strength training groups. Exercise as a coping strategy during the stay-at-home period was associated with psychological well-being, with different impacts observed depending on the type of activity.

Change in subjective health status among frail older Japanese people owing to the coronavirus disease pandemic and characteristics of their responses.
Takeshi Kera; Hisashi Kawai; Manami Ejiri; Junta Takahashi; Kazumasa Nishida; Akihiro Harai; Hirohiko Hirano; Yutaka Watanabe; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Shuichi Obuchi
Geriatrics & gerontology international, 21, 11, 1053, 1059, Nov. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: The coronavirus disease 2019 (COVID-19) pandemic remains a major global public health issue, and it has led to restrictions in physical and social activities among community-dwelling people, including frail older adults. This study aimed to determine the impact of the pandemic on the subjective health status and characteristics of community-dwelling frail older adults by assessing their knowledge of infection, behaviors and negative psychological response. METHODS: During October 2019, 720 older adults participated in "The Otassha Study." A year after the COVID-19 outbreak, between June 29 and July 31, 2020, a health status questionnaire, comprising questions concerning knowledge about infection, behaviors and psychological responses during the pandemic, was sent to all participants of the health examination in 2019. Respondents were divided into the robust and frail groups, and their responses were compared. RESULTS: Although the self-reported health status of the older adults in both groups was worse in 2020 than in 2019, differences were not observed in the degree of deterioration between the groups. Those in the frail group had fewer resources of information related to COVID-19 and had fewer coping behaviors for health maintenance compared with the robust group. CONCLUSION: Information gathering and actions aimed at health maintenance tended to be weaker among older adults with frailty, although the influence of COVID-19 on subjective health status did not differ significantly between robust and frail adults. Therefore, robust and frail older adults may need to adopt different countermeasures to prevent worse health during this pandemic. Geriatr Gerontol Int 2021; ••: ••-••.

Relationship between weight loss and regular dental management of older adults residing in long-term care facilities: a 1-year multicenter longitudinal study.
Yusuke Sunakawa; Hideki Tsugayasu; Yutaka Watanabe; Takae Matsushita; Yuki Ohara; Masanori Iwasaki; Maki Shirobe; Kayoko Ito; Junko Nakajima; Yasuyuki Iwasa; Masataka Itoda; Rikimaru Sasaki; Yasuhiro Nishi; Junichi Furuya; Yoshihiko Watanabe; Yukie Ishiguro; Hirohiko Hirano; Yuji Sato; Mitsuyoshi Yoshida; Yutaka Yamazaki
European geriatric medicine, 13, 1, 221, 231, 28 Oct. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, PURPOSE: This study aimed to determine the association between home visits by a dentist and regular oral hygiene management by a dental hygienist (regular dental management: RDM) and weight loss among older adults in long-term care facilities. METHODS: A total of 468 older residents from 26 Japanese long-term care facilities participated in two surveys in 2018 and 2019. Participants were divided into two groups based on their diet during the baseline survey (regular diet, n = 256; dysphagia diet, n = 212). Participants with a regular diet were further divided into those who exhibited a weight loss ≥ 5% over 1 year (weight loss group: n = 77) and those with a weight loss < 5% (consistent weight group: n = 179). The explanatory variables were age, sex, baseline weight, Barthel index, and clinical dementia rating, as well as the patients' medical history of pneumonia, stroke, diabetes, and depression (which is reportedly associated with weight). Additionally, a Poisson regression with robust standard error, was carried out to analyze the explanatory variables, namely the prevalence of RDM noted during the study and functional teeth (which seemed to affect weight loss). RESULTS: A multivariate analysis revealed that older residents' lack of RDM, clinical dementia assessment, and their history of pneumonia (prevalence rate ratio: 0.35, 95% confidence interval 0.24-0.95) were all significantly associated with weight loss when on a regular diet. CONCLUSION: Thus, weight loss and RDM were related to each other. Weight loss may be suppressed by incorporating RDMs during the early nursing care for older residents on regular diets.

Association between Weight Loss and Food Form in Older Individuals Residing in Long-Term Care Facilities: 1-Year Multicenter Longitudinal Study.
Akemi Endo; Yutaka Watanabe; Takae Matsushita; Kazutaka Okada; Yuki Ohara; Masanori Iwasaki; Kayoko Ito; Junko Nakajima; Yasuyuki Iwasa; Masataka Itoda; Rikimaru Sasaki; Yasuhiro Nishi; Junichi Furuya; Yoshihiko Watanabe; George Umemoto; Masako Kishima; Hirohiko Hirano; Yuji Sato; Mitsuyoshi Yoshida; Yutaka Yamazaki
International journal of environmental research and public health, 18, 20, 14 Oct. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, Changing the food form for older adults requiring nursing care from a regular to dysphagia diet is thought to impact their nutritional status. We assessed the association between changes in food form and weight loss over 1 year in older adults. Older adults residing in long-term care facilities in Japan (n = 455) who participated in the baseline (2018) and follow-up (2019) surveys were divided into two groups (regular diet, n = 284; dysphagia diet, n = 171). The regular diet group was further divided into the weight loss (n = 80; weight loss ≥5% over 1 year) and weight maintenance (n = 204; weight loss <5%) groups. After 1 year, the Barthel Index significantly decreased, and the proportion of participants who switched from a regular diet to a dysphagia diet significantly increased in the weight loss group than in the weight maintenance group. Multivariate logistic regression analysis found that Barthel index variation (odds ratio (OR): 0.97, 95% confidence interval (CI): 0.94‒0.99), change from a regular diet to a dysphagia diet (OR: 4.41, 95% CI: 1.87‒10.41), and body weight at baseline (OR = 1.06, 95% CI: 1.01‒1.11) were significantly associated with weight loss. Our results suggest that maintaining the food form inhibits weight loss and improves health outcomes in older adults.

三叉神経痛症状を呈した高齢者に発見された小脳橋角部の類上皮腫の2例
中川 紗百合; 新井 絵理; 松下 貴惠; 山野 茂; 松下 和裕; 渡邊 裕; 山崎 裕
北海道歯学雑誌, 42, 70, 75, 北海道歯学会, Sep. 2021, [Peer-reviewed]
Japanese

The relationship between blood pressure and cognitive function.
Joji Ishikawa; Satoshi Seino; Akihiko Kitamura; Ayumi Toba; Kenji Toyoshima; Yoshiaki Tamura; Yutaka Watanabe; Yoshinori Fujiwara; Hiroki Inagaki; Shuichi Awata; Shoji Shinkai; Atsushi Araki; Kazumasa Harada
International journal of cardiology. Cardiovascular risk and prevention, 10, 200104, 200104, Sep. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: Although an elevated systolic blood pressure (SBP) is associated with cognitive dysfunction, BP may decrease with advanced cognitive dysfunction; therefore, we attempted to identify the turning point in the relationship between cognitive function and SBP in elderly subjects. Methods: In pooled datasets of general populations and outpatient clinics (age>65 years), in which the risk of frailty or cognitive dysfunction was assessed (N = 4076), the relationship between SBP and the Mini Mental State Examination (MMSE) score was examined. Results: Mean age was 72.5 ± 6.2 years (male 45.1%), and SBP was 133.0 ± 19.5 mmHg. In an analysis of locally weighted scatter plot smoothing, the relationship between SBP and MMSE scores changed at an MMSE score of 24 points. In subjects with preserved cognitive function (MMSE ≥24 points), MMSE scores decreased with increases in SBP (B = -0.047 per 10 mmHg increase, P = 0.002) after adjustments for age, sex, body mass index, alcohol habit, smoking status, diabetes, a history of stroke, and the geriatric nutritional index; however, in subjects with reduced cognitive function (MMSE<24 points), decreases in the MMSE score were associated with reductions in SBP (B = 1.178 per 1 point decrease in the MMSE score, P = 0.002). Conclusion: The relationship between SBP and cognitive function changed at a MMSE score of approximately 24 points (mild to moderate cognitive dysfunction). In patients with preserved MMSE, higher BP values were associated with a reduction of cognitive function, but this was not a case for those with impaired MMSE.

Denture wearing is associated with nutritional status among older adults requiring long-term care: A cross-sectional study
Ayami Meguro; Yuki Ohara; Masanori Iwasaki; Ayako Edahiro; Maki Shirobe; Kentaro Igarashi; Keiko Motokawa; Masayasu Ito; Yutaka Watanabe; Yasuhiko Kawai; Hirohiko Hirano
Journal of Dental Sciences, 17, 1, 500, 506, Elsevier BV, Aug. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background/purpose: Dentures are important for the reconstruction of occlusal support and masticatory performance for older adults with poor dentition. We aimed to elucidate the oral health factors associated with malnutrition in older adults requiring long-term care, including denture use. Materials and methods: This cross-sectional study included 322 older adults (63 men, 259 women; mean age, 86.6 ± 6.9 years) who required long-term care in rural Japan. The participant's nutritional status was assessed using the Mini Nutritional Assessment-Short Form (MNA®-SF). Oral health was assessed using participant's dentition and oral function. Barthel Index (BI) and medical history were measured for assessing general health status. Multiple logistic regression analyses were performed to determine the oral health factors associated with malnutrition. Results: The proportion of participants with malnutrition was 17.2%. The BI score (odds ratio [OR], 0.95; 95% confidence interval [CI] 0.93-0.98, p<0.001), having <20 teeth and dentures (OR 0.42; 95%CI 0.18-0.99; p = 0.047), and poor lip-closure ability (OR 2.86; 95%CI 1.32-6.20; p = 0.008) were significantly associated with malnutrition. Conclusion: Denture use, lip-closure ability, and activities of daily living were significantly associated with malnutrition in older adults requiring long-term care, suggesting that wearing dentures for tooth loss and maintaining oral function contributes to nutritional status.

Effect of an Oral Frailty Measures Program on Community-Dwelling Elderly People: A Cluster-Randomized Controlled Trial.
Maki Shirobe; Yutaka Watanabe; Tomoki Tanaka; Hirohiko Hirano; Takeshi Kikutani; Kazuko Nakajo; Tetsuro Sato; Junichi Furuya; Shunsuke Minakuchi; Katsuya Iijima
Gerontology, 1, 10, 09 Jul. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, INTRODUCTION: Oral frailty describes a trivial decline in the oral function and is considered to be related to frailty. Thus, effective management of oral frailty could prevent or ameliorate physical frailty and the need for care. However, there is a lack of consensus regarding specific interventions for oral frailty. In this cluster-randomized controlled trial, we investigated the effects of a newly developed oral frailty measures program mentored by dentists and dental hygienists for elderly people in a clinical setting. METHODS: Of 3,296 participants included in a field survey, 219 who regularly visited dental clinics and met at least 3 of the following 6 criteria for oral frailty were considered eligible: <20 natural teeth, decreased chewing ability, decreased articulatory oral-motor skills, decreased tongue pressure, and substantial subjective difficulties in eating and swallowing. After applying the inclusion and exclusion criteria, we studied 51 patients in the intervention group (14 men and 37 women; mean age, 78.6 years) and 32 patients in the control group (7 men and 25 women; mean age, 78.0 years). We implemented a 12-week oral frailty measures program only for the intervention group. The program included preparatory oral exercises, mouth-opening training, tongue pressure training, prosodic training, and masticatory training. Primary outcome measures were the chewing ability score, articulatory oral motor skill for /ta/, tongue pressure, subjective difficulty in eating tough foods, and subjective difficulty in swallowing. We compared baseline characteristics using the Mann-Whitney U and χ2 tests for continuous and categorical variables, respectively. A repeated-measures two-way ANOVA was used to determine the efficacy of independent intervention variables, following the Wilcoxon signed-rank test. The groups (intervention/control) and time (baseline/week 12) were the independent variables. Oral frailty measures were the dependent variables. RESULTS: Baseline characteristics and assessment results were similar between groups. We observed significant improvements in the intervention group in terms of articulatory oral motor skill for /ta/ and tongue pressure (p < 0.001). No improvements were observed in the control group. DISCUSSION/CONCLUSION: Our results suggest that our oral frailty measures program effectively alleviates oral frailty. Future studies are needed to clarify the impact on preventing physical frailty and improving the nutritional status.

Intra-day variation in daily outdoor walking speed among community-dwelling older adults.
Hisashi Kawai; Shuichi Obuchi; Ryo Hirayama; Yutaka Watanabe; Hirohiko Hirano; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Yoshiyuki Kobayashi; Masaaki Mochimaru; Eiki Tsushima; Kozo Nakamura
BMC geriatrics, 21, 1, 417, 417, 08 Jul. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Walking speed is an important measure associated with health outcomes in older individuals, such as dependency and death. This study aimed to examine whether the walking speed of community-dwelling older adults varies between time periods within a day, as measured outdoors in daily life. We aimed to determine the types of walking speed variations and examine the factors associated with them. METHODS: Daily life outdoor walking speed was measured in 92 participants (average age 71.9 years±5.64) using a GPS smartphone app for 1 month. Average walking speeds for five time periods were analyzed with a linear mixed model. Intra-day walking speed variation patterns were classified by latent class analysis. Factors associated with the class were identified by logistic regression analysis. RESULTS: A statistically significant difference in average walking speed was found between early morning (1.33 m/s), and afternoon (1.27 m/s) and evening (1.26 m/s) (p < 0.01). The intra-day variation in walking speed was attributed to variation in cadence. Two classes were identified: (1) fast walking speed with large variation and (2) slow walking speed with little variation; hypertension and frailty level were associated with the class. CONCLUSION: The results suggest that there is intra-day variation in walking speed in daily life, wherein the speed is the fastest early in the morning and slower in the afternoon and evening. A larger variation in the walking speed was related to the health status without hypertension or frailty. These results suggest that if a person shows less intra-day variation in walking speed, this could be a sign that they are susceptible to hypertension and an increased frailty level.

都市部高齢者の中枢性感作に対する主観的QOLおよび社会的孤立の影響
橋本 和明; 竹内 武昭; 今村 英之; 大渕 修一; 河合 恒; 平野 浩彦; 藤原 佳典; 金 憲経; 井原 一成; 渡邉 裕; 端詰 勝敬
心身医学, 61, 5, 451, 459, (一社)日本心身医学会, Jul. 2021, [Peer-reviewed]
Japanese

Oral hypofunction and malnutrition among community-dwelling older adults: Evidence from the Otassha study.
Masanori Iwasaki; Keiko Motokawa; Yutaka Watanabe; Maki Shirobe; Yuki Ohara; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Hunkyung Kim; Kazushige Ihara; Shuichi Obuchi; Hirohiko Hirano
Gerodontology, 01 Jul. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: This study investigated the association between oral hypofunction and malnutrition among community-dwelling older adults. BACKGROUND: Oral hypofunction, a 7-component phenotype of the clinical features of oral health, has been described in Japan. Data about its association with nutritional status are limited. MATERIALS AND METHODS: This cross-sectional study enrolled 715 adults (mean age, 73.5 years; range, 65-91 years) from the Otassha Study. Oral hypofunction was defined as the presence of ≥3 of the following 7 components: poor oral hygiene; oral dryness; low occlusal force; low articulatory oral motor skill; low tongue pressure; low masticatory performance; and compromised swallowing function. The Mini Nutritional Assessment® -Short Form (MNA® -SF) was used to assess the nutritional status. Malnutrition was defined as having an MNA® -SF score of seven or less. The association between oral hypofunction and nutritional status was evaluated using ordinal logistic regression analyses. RESULTS: The prevalence rates of oral hypofunction and malnutrition were 42.7% and 4.1%, respectively. Multivariable Poisson regression analyses revealed that oral hypofunction was associated with malnutrition. The adjusted relative risk of malnutrition in the study participants with oral hypofunction was 3.00 with a 95% confidence interval of 1.29-6.98. CONCLUSION: Community-dwelling older adults whose oral functions were compromised in multiple aspects had poor nutritional status.

The effectiveness of a desensitization technique for mitigating oral and facial tactile hypersensitivity in institutionalized older persons: A randomized controlled trial.
Maki Shirobe; Rena Hidaka; Hirohiko Hirano; Yuki Ohara; Keiko Endo; Yutaka Watanabe; Chiyoko Hakuta
Journal of dental sciences, 16, 3, 987, 993, Jul. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, Background/purpose: Oral health care provision in long-term care settings is often limited by specific behaviors exhibited by residents, which may be interpreted as a refusal of care. Such behaviors can be attributed to oral tactile hypersensitivity (TH), which is characterized by aberrations in the perception of oral stimuli. TH is also associated with a decline in ingestion and swallowing function. The purpose of this study was to examine the effectiveness of a technique for mitigating TH (TMH) among institutionalized older persons. Materials and methods: In this study, 18 institutionalized older persons (Mean age, 90.6 ± 4.5 years; 92.9% females) with TH were randomized to a control group or an intervention group. Pre- and post-intervention assessments were conducted for seven participants in each group. Routine oral care was provided by the facility's staff in both groups. TMH in the intervention group was performed by a dental hygienist over a 3-month period. Results: In the intervention group, the number of areas with TH was significantly reduced (P = 0.027). No significant change was observed in the control group. Conclusion: The results of this study suggest that TMH can effectively mitigate TH. Our findings provide clinicians with an additional treatment option for hypersensitivity in older patients. Additional long-term studies with larger sample sizes are required to confirm the effectiveness of this technique.

Relationship between Oral Hypofunction and Sarcopenia in Community-Dwelling Older Adults: The Otassha Study.
Yoshihiro Kugimiya; Masanori Iwasaki; Yuki Ohara; Keiko Motokawa; Ayako Edahiro; Maki Shirobe; Yutaka Watanabe; Shuichi Obuchi; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Takayuki Ueda; Hirohiko Hirano
International journal of environmental research and public health, 18, 12, 21 Jun. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Oral hypofunction, resulting from a combined decrease in multiple oral functions, may affect systemic-condition deterioration; however, few studies have examined the association between oral hypofunction and general health among older adults. In this cross-sectional study, we examined the relationship between oral hypofunction and sarcopenia in community-dwelling older adults. We included 878 adults (268 men and 610 women, mean age 76.5 ± 8.3 years). Tongue coating index, oral moisture, occlusal force, oral diadochokinesis (/pa/,/ta/,/ka/), tongue pressure, mas-ticatory function, and swallowing function were evaluated as indicators of oral hypofunction. Grip strength, gait speed, and skeletal muscle mass index were measured as diagnostic sarcopenia parameters. The association between oral hypofunction and sarcopenia was examined via logistic regression using sarcopenia as the dependent variable. Oral hypofunction prevalence was 50.5% overall, 40.3% in men, and 54.9% in women. The prevalence of sarcopenia was 18.6% overall, 9.7% in men, and 22.5% in women. A logistic regression showed oral hypofunction, age, body mass index, higher-level functional capacity, and serum albumin level were significantly associated with sarcopenia. Sarcopenia occurred at an increased frequency in patients diagnosed with oral hypofunction (odds ratio: 1.59, 95% confidence interval: 1.02-2.47); accordingly, oral hypofunction appears to be significantly associated with sarcopenia.

下顎腫瘍術後高齢患者に装着した下顎顎義歯の安定因子に関するパイロット・スタディ
尾崎 公哉; 岡田 和隆; 馬場 陽久; 近藤 美弥子; 松下 貴惠; 渡邊 裕; 山崎 裕
老年歯科医学, 36, 1, 65, 71, (一社)日本老年歯科医学会, Jun. 2021, [Peer-reviewed]
Japanese

歯科訪問診療における感染予防策の指針 2021年版
水口 俊介; 佐藤 裕二; 小玉 剛; 猪原 光; 小原 由紀; 金久 弥生; 菊谷 武; 菅 武雄; 花形 哲夫; 米山 武義; 渡邊 裕; 渡部 芳彦; 古屋 純一; 吉田 光由; 猪原 健; 河野 雅臣; 佐藤 繭美; 宮本 雄気; 一般社団法人日本老年歯科医学会, 在宅歯科医療委員会, 一般社団法人日本在宅医療連合学会
老年歯科医学, 36, 1, E4, E33, (一社)日本老年歯科医学会, Jun. 2021, [Peer-reviewed], [Invited]
Japanese

Gender differences in the relationship between personality, cognitive function and regular dental visits in Japanese community-dwelling older adults.
Chieko Kubota; Shingo Moriya; Yohei Hama; Rie Onda; Yutaka Watanabe; Yoko Uchida
International journal of dental hygiene, 23 Apr. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Studies have examined the association between personality and health behaviour, but research focusing exclusively on regular dental visits has yet to be conducted. This study examined the association between personality traits and regular dental visits among Japanese community-dwelling older adults. METHODS: The participants in this cross-sectional study included 1,057 community-dwelling older adults aged 65-74 years from Ranzan and Yoshimi towns; data were collected from October to November 2015 and October to November 2016, respectively. Interviews were conducted to obtain sociodemographic, income, occupation and medical data. The Tokyo Metropolitan Institute of Gerontology Index of Competence was used to assess higher-level competence; general intelligence was also evaluated. The 'Big Five' personality traits-openness to experience, consciousness, neuroticism, extraversion and agreeableness-were also examined. A multivariable logistic regression analysis was performed to examine the relationship between regular dental visits and personality traits. RESULTS: Among men, the number of natural teeth, current employment status and conscientiousness were associated with dental care utilization. Among women, the number of natural teeth, current annual income, the intellectual activity domain of the Tokyo Metropolitan Institute of Gerontology Index of Competence and openness were significant. CONCLUSIONS: The factors associated with regular dental visits differed by gender. Overall, work was associated with men's visits, whereas intellectual activity and economic factors were relevant to women. Factors such as personality traits should be considered when addressing barriers to oral health. Understanding personality traits will help practitioners more effectively encourage older adults to make dental visits.

地域在住高齢者における口腔機能低下有訴者の口腔機能 後期高齢者の質問票を構成する口腔機能関連項目を用いた検討
釘宮 嘉浩; 岩崎 正則; 小原 由紀; 本川 佳子; 枝広 あや子; 白部 麻樹; 渡邊 裕; 大渕 修一; 河合 恒; 解良 武士; 藤原 佳典; 井原 一成; 金 憲経; 五十嵐 憲太郎; 星野 大地; 平野 浩彦
日本老年医学会雑誌, 58, 2, 245, 254, (一社)日本老年医学会, Apr. 2021, [Peer-reviewed]
Japanese

Factors Associated with Denture Non-use in Older Adults Requiring Long-Term Care.
Ayami Meguro; Yuki Ohara; Ayako Edahiro; Maki Shirobe; Masanori Iwasaki; Kentaro Igarashi; Keiko Motokawa; Masayasu Ito; Yutaka Watanabe; Yasuhiko Kawai; Hirohiko Hirano
Archives of gerontology and geriatrics, 95, 104412, 104412, 31 Mar. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Evidence suggests that denture non-use is significantly associated with activities of daily living, oral function, and cognitive decline. Few studies have focused on the possibility that the indications for denture use may differ depending on the cognitive and physical functions in older adults requiring long-term care. OBJECTIVES: The aim of this study was to elucidate the factors associated with denture non-use in older adults requiring long-term care. METHODS: This cross-sectional study comprised 201 older adults (45 men and 156 women; average age = 86.2 ± 7.1 years) requiring long-term care in Japan. Those who did not require denture treatment were classified by dentists into denture-use and denture non-use groups. The severity of dementia was assessed using the Clinical Dementia Rating scale. Multiple logistic regression analyses were conducted to detect the factors significantly associated with denture non-use. RESULTS: The proportion of participants without dentures was 58.2%. Multiple logistic regression analyses revealed that a moderate dementia (odds ratio [OR], 4.44; 95% confidence interval [CI] 1.18-16.71, p=0.027) and rinsing ability (OR 3.00; 95% CI 1.12-8.06; p=0.030) were significant factors related to the non-use of dentures. CONCLUSION: Severity of dementia and rinsing ability were significantly associated with non-use of dentures. These findings indicate the necessity of evaluating oral and cognitive functions while planning denture treatment in older adults requiring long-term care.

最新の歯学 オーラルフレイル
渡邊 裕; 岡田 和隆; 近藤 美弥子; 中澤 誠多朗; 松下 貴恵; 山崎 裕
北海道歯学雑誌, 41, 2, 110, 115, 北海道歯学会, Mar. 2021, [Peer-reviewed], [Invited]
Japanese

電撃様疼痛の原因探索に難渋した二次性三叉神経痛の1例
稲本 香織; 中川 紗百合; 松下 貴恵; 中澤 誠多朗; 坂田 健一郎; 羽藤 裕之; 渡邊 裕; 山崎 裕
北海道歯学雑誌, 41, 2, 147, 152, 北海道歯学会, Mar. 2021, [Peer-reviewed]
Japanese

Differences in the association between white matter hyperintensities and gait performance among older adults with and without cognitive impairment.
Ryota Sakurai; Hiroki Inagaki; Aya M Tokumaru; Keita Sakurai; Keigo Shimoji; Kimi E Kobayashi-Cuya; Akihiko Kitamura; Yutaka Watanabe; Shoji Shinkai; Shuichi Awata
Geriatrics & gerontology international, 21, 3, 313, 320, Mar. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: Gait impairment implies subtle cognitive impairment (CI) and is associated with severity of white matter hyperintensities (WMHs). However, cognitive differences in such an association are not yet fully understood. This study examined the association between WMHs and gait performance among three cognitively different older groups. METHODS: Gait performance and WMHs were assessed in 150 community-dwelling older adults, comprising 53 with CI (Mini-Mental State Examination [MMSE] score <24), 63 with mild CI (MMSE score ≥24 and Montreal Cognitive Assessment [MoCA] score <25), and 34 who were cognitively normal or preserved (MMSE ≥24 and MoCA score ≥25). Gait velocity and variability were assessed on a 5-m electronic walkway. Furthermore, WMH volume was derived by automated segmentation using 1.5 T magnetic resonance imaging. RESULTS: Adjusted multiple regression analyses showed that greater WMHs were associated with slower gait velocity and greater temporal (stride time) and spatial (stride and step lengths) variabilities among older adults with CI. In contrast, WMH was only associated with spatial variability in older adults with mild CI and in cognitively normal or preserved older adults. CONCLUSIONS: Our findings suggest that gait variability measures are more sensitive to subtle underlying neurological pathologies including WMHs in older adults. The cognitive-dependent differences found in the association between WMHs and gait performance suggests that the level of cognitive function interferes with the association between WMH and gait performance. Geriatr Gerontol Int 2021; ••: ••-••.

Oral frailty and gait performance in community-dwelling older adults: findings from the Takashimadaira study.
Masanori Iwasaki; Yutaka Watanabe; Keiko Motokawa; Maki Shirobe; Hiroki Inagaki; Yoshiko Motohashi; Yurie Mikami; Yu Taniguchi; Yosuke Osuka; Satoshi Seino; Hunkyung Kim; Hisashi Kawai; Ryota Sakurai; Ayako Edahiro; Yuki Ohara; Hirohiko Hirano; Shoji Shinkai; Shuichi Awata
Journal of prosthodontic research, 65, 4, 467, 473, 22 Feb. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, PURPOSE: This cross-sectional study compared gait performance between community-dwelling older adults with and without accumulated deficits in oral health, defined as oral frailty. METHODS: A total of 1,082 individuals (439 men and 643 women; mean age, 77.1 years) from the Takashimadaira study were included in the current analysis. Based on a multifaceted oral health assessment, oral frailty was defined as having three or more of the following six components: (i) fewer teeth, (ii) low masticatory performance, (iii) low articulatory oral motor skills, (iv) low tongue pressure, (v) difficulties in eating, and (vi) swallowing. Eight gait parameters were assessed using an electronic walkway. Gait characteristics comparison between groups with and without oral frailty was performed using multiple linear regression models. Models were adjusted for age, sex, educational status, income, smoking, drinking, physical activity level, height, body mass index, comorbidities, and the presence of chronic pain. RESULTS: Oral frailty was observed in 227 (21.0%) participants. After adjusting for potential confounders, the participants with oral frailty had slower gait speed, shorter stride and step length, wider step width, and longer double support duration as well as higher variability of stride length and step length. CONCLUSIONS: Oral frailty was associated with poor gait performance among community-dwelling older adults.

Low Dietary Variety and Diabetes Mellitus Are Associated with Frailty among Community-Dwelling Older Japanese Adults: A Cross-Sectional Study.
Misato Hayakawa; Keiko Motokawa; Yurie Mikami; Kaori Yamamoto; Maki Shirobe; Ayako Edahiro; Masanori Iwasaki; Yuki Ohara; Yutaka Watanabe; Hisashi Kawai; Motonaga Kojima; Shuichi Obuchi; Yoshinori Fujiwara; Hunkyung Kim; Kazushige Ihara; Hiroki Inagaki; Shoji Shinkai; Shuichi Awata; Atsushi Araki; Hirohiko Hirano
Nutrients, 13, 2, 16 Feb. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, The association between dietary diversity and frailty remains unknown in older people. We evaluated whether a limited dietary variety is associated with frailty in older adults with diabetes mellitus (DM). This cross-sectional investigation included 1357 adults (median age: 77 years, women: 61.3%). DM was determined by self-reporting, the Dietary Variety Score (DVS) was used to evaluate dietary variety, and the revised Japanese version of the Cardiovascular Health Study criteria evaluated frailty. Participants were divided into 4 groups: no DM/high DVS (non-DMHV), no DM/low DVS (non-DMLV), DM/high DVS (DMHV), and DM/low DVS (DMLV). The prevalence of frailty in each group was 3.6%, 6.7%, 6.7%, and 12.2%. After adjusting for covariates, logistic regression analysis revealed the highest odds ratio (OR) of frailty in the DMLV (non-DMLV, OR = 2.18 (95% confidence interval (CI): 1.25-3.83); DMHV, OR = 1.87 (95% CI: 0.63-5.52); DML, OR = 5.03 (95% CI: 2.05-12.35)). Another logistic regression analysis revealed that a low DVS and DM were independently associated with frailty. Both a low dietary variety and DM were independently related to frailty in older people and the combination increased the prevalence of frailty. These findings suggest that high dietary variety could be important for the prevention of frailty in people with DM.

Association between activity diversity and frailty among community-dwelling older Japanese: A cross-sectional study.
Junta Takahashi; Hisashi Kawai; Yoshinori Fujiwara; Yutaka Watanabe; Hirohiko Hirano; Hunkyung Kim; Kazushige Ihara; Manami Ejiri; Kaori Ishii; Koichiro Oka; Shuichi Obuchi
Archives of gerontology and geriatrics, 95, 104377, 104377, 12 Feb. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: Deterioration of daily activities increases frailty risk. Most of the previous research has examined the association between frailty and specific activities; nevertheless, the diversity of daily activities is also important. Although the type, frequency, and evenness of daily activities have been proposed as indicators of activity diversity, the association between these indicators and frailty remains unclear. In this study, we examined the association between activity diversity and frailty in community-dwelling older adults. MATERIALS AND METHODS: This cross-sectional study comprised 658 community-dwelling older adults aged ≥ 65 years who participated in comprehensive health check-ups in 2018. Frailty was defined using the Japanese version of the Cardiovascular Health Study criteria. Three indicators, type, frequency, and evenness of daily activities, were used to assess activity diversity across one week. Multiple logistic regression analyses were performed, with frailty as the dependent variable and the three activity diversity indicators as independent variables. Socio-demographic, physical, and mental functioning factors were adjusted as covariates. RESULTS: Of the 658 participants (median age: 72 years; age range: 65-91 years; 60.5% women), 27 (4.1%) met the criteria for frailty. The frail group had significantly lower scores for type, frequency, and evenness of daily activities, as well as Mini-Mental State Examination scores (all at p < 0.01). We found significant independent associations in all activity diversity indicators with frailty, in multiple logistic models. CONCLUSION: Activity diversity is independently associated with frailty in community-dwelling older adults.

Relationship between Mortality and Oral Function of Older People Requiring Long-Term Care in Rural Areas of Japan: A Four-Year Prospective Cohort Study.
Shiho Morishita; Yuki Ohara; Masanori Iwasaki; Ayako Edahiro; Keiko Motokawa; Maki Shirobe; Junichi Furuya; Yutaka Watanabe; Takeo Suga; Yayoi Kanehisa; Akitugu Ohuchi; Hirohiko Hirano
International journal of environmental research and public health, 18, 4, 10 Feb. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Oral ingestion influences the life sustenance, quality of life, and dignity of older adults. Thus, it is an important issue in medical care and the welfare of older adults. The purpose of this four-year prospective cohort study was to investigate the relationship between mortality and oral function among older adults who required long-term care and were living in different settings in a rural area of Japan. This study included 289 participants aged 65 and older who required long-term care and lived in the former Omorimachi area in Yokote City, Akita Prefecture, located in northern Japan. Following the baseline survey, mortality data were collected over four years; 102 participants (35.3%) died during that time. A significant difference was noted in the overall survival rates between the groups with good and deterioration of oral function such as oral dryness, rinsing ability, swallowing function, and articulation, based on Log-rank test results. After adjusting for various potential confounders using Cox proportional-hazards regression, oral dryness (HR: 1.83, 95% confidence interval: 1.12-3.00) was significantly associated with mortality within four years. This study revealed that oral dryness influences the life prognosis of older adults who receive long-term care in different settings.

Dietary variety is associated with sleep efficiency in urban-dwelling older adults: A longitudinal study.
Kaori Yamamoto; Keiko Motokawa; Takahiro Yoshizaki; Tomohiro Yano; Hirohiko Hirano; Yuki Ohara; Maki Shirobe; Misato Hayakawa; Hiroki Inagaki; Shuichi Awata; Shoji Shinkai; Yutaka Watanabe
Clinical nutrition ESPEN, 41, 391, 397, Feb. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND & AIMS: Improving sleep quality is important for an aging society. However, no study has been conducted on the association between dietary variety and sleep efficiency among older Japanese adults using longitudinal data. The current study is a longitudinal study that aimed to elucidate the association between dietary variety and sleep efficiency in older Japanese adults. METHODS: This study was conducted among older adults (≥70 years old in 2016) in the metropolitan area of Tokyo, Japan, between 2016 and 2018. Dietary variety score (DVS) and sleep efficiency were determined for all participants and were used to assess dietary habits and sleep quality, respectively. A cross-lagged panel analysis was used to consider the prospective associations between DVS and sleep efficiency, and this analysis was performed before and after adjusting for possible covariates in the 2016 data. RESULTS: After adjusting for age, sex, body mass index, current drinking status, current smoking status, exercise habits, living (alone or with others) style, the Japanese version of the Geriatric Depression Scale (Short Form), sleep duration and retiring time the DVS in 2016 predicted the sleep efficiency in 2018 (β = 0.130, p < 0.05). CONCLUSION: The possibility that DVS can predict sleep efficiency 2 years later was demonstrated.

Relationship between Chewing Ability and Nutritional Status in Japanese Older Adults: A Cross-Sectional Study.
Keiko Motokawa; Yurie Mikami; Maki Shirobe; Ayako Edahiro; Yuki Ohara; Masanori Iwasaki; Yutaka Watanabe; Hisashi Kawai; Takeshi Kera; Shuichi Obuchi; Yoshinori Fujiwara; Kazushige Ihara; Hirohiko Hirano
International journal of environmental research and public health, 18, 3, 29 Jan. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: This study aimed to determine the relationship between objective chewing ability and the nutritional status of Japanese community-dwelling elders. DESIGN: A cross-sectional study. PARTICIPANTS: A total of 509 community-dwelling elders living in the Tokyo metropolitan area participated in a comprehensive survey conducted in October 2013. MEASUREMENTS: The basic characteristics were sex, age, and body mass index. Undernutrition was examined through serum albumin levels. Chewing ability was examined through color-changeable xylitol gum by evaluating the color changes in chewing gum. Nutritional intake was examined using the semi-quantitative food frequency questionnaire. RESULTS: In the poor chewing ability group, all nutrient intake levels were significantly low, except for carbohydrates, and intake levels for all food groups were significantly low, except for cereals, confectionery, sugars, seasonings, and spices. Additionally, after adjusting for covariates for sex, age, Tokyo Metropolitan Institute of Gerontology-Index of Competence (TMIG-IC) score, Mini-Mental State Examination (MMSE) score, body mass index (BMI), stroke, number of functional teeth, energy intake, and protein intake, chewing ability was found to be significantly associated with undernutrition. CONCLUSION: We concluded that chewing ability was closely associated with nutrient and different food groups' intake, as well as undernutrition, among Japanese community-dwelling elders. Thus, to ensure comprehensive nutritional management, nutritionists and dentists should collaborate when treating the same patients.

Association of nutrient-derived dietary patterns with sarcopenia and its components in community-dwelling older Japanese: a cross-sectional study.
Yuri Yokoyama; Akihiko Kitamura; Satoshi Seino; Hunkyung Kim; Shuichi Obuchi; Hisashi Kawai; Hirohiko Hirano; Yutaka Watanabe; Keiko Motokawa; Miki Narita; Shoji Shinkai
Nutrition journal, 20, 1, 7, 7, 18 Jan. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Diet is a modifiable factor affecting sarcopenia, and accumulating evidence links dietary factors to muscle mass, strength, and function in older adults. However, few studies have examined the association of dietary patterns with sarcopenia. This study examined the association of dietary patterns derived by reduced-rank regression (RRR) with sarcopenia and its components in community-dwelling older Japanese. METHODS: We conducted a cross-sectional study of 1606 community-dwelling adults aged 65 years or older. Dietary intake was assessed by a validated, self-administered diet history questionnaire. Nutrient-derived dietary patterns were identified by using RRR, with sarcopenia-related nutrients (protein, vitamin D, vitamin C, vitamin E, folate, vitamin K, magnesium, iron, and calcium intakes) as response variables. Sarcopenia was defined by using the algorithm of the Asian Working Group for Sarcopenia 2019. Multivariate regression and logistic regression were used to examine the association of dietary patterns with sarcopenia and its components. RESULTS: The first RRR dietary pattern was characterized by high intakes of fish, soybean products, potatoes, most vegetables, mushrooms, seaweeds, and fruit and a low intake of rice and was associated with decreased prevalence of sarcopenia: the multivariable-adjusted odds ratio of sarcopenia was 0.57 (95% confidence interval, 0.34-0.94; p for trend=0.022) in the highest versus the lowest tertile of dietary pattern. This dietary pattern was also significantly positively associated with usual gait speed (β: 0.02, p=0.024). CONCLUSIONS: A dietary pattern characterized by high intakes of fish, soybean products, potatoes, most vegetables, mushrooms, seaweeds, and fruits and low rice intake was inversely associated with sarcopenia in community-dwelling older Japanese.

MMSE Cutoff Discriminates Hippocampal Atrophy: Neural Evidence for the Cutoff of 24 Points.
Ryota Sakurai; Yuri Kim; Hiroki Inagaki; Aya M Tokumaru; Keita Sakurai; Keigo Shimoji; Akihiko Kitamura; Yutaka Watanabe; Shoji Shinkai; Shuichi Awata
Journal of the American Geriatrics Society, 69, 3, 839, 841, 08 Jan. 2021, [Peer-reviewed], [International Magazine]
English

Nutritional status and body composition in cognitively impaired older persons living alone: The Takashimadaira study.
Masanori Iwasaki; Keiko Motokawa; Yutaka Watanabe; Misato Hayakawa; Yurie Mikami; Maki Shirobe; Hiroki Inagaki; Ayako Edahiro; Yuki Ohara; Hirohiko Hirano; Shoji Shinkai; Shuichi Awata
PloS one, 16, 11, e0260412, 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: To investigate nutritional status and body composition in cognitively impaired older persons living alone. METHODS: This cross-sectional study included 1051 older adults (633 women and 418 men, mean age: 77.1 years) from the Takashimadaira study. The study participants were categorized according to whether they lived alone, which was confirmed via questionnaire, and had cognitive impairment, which was defined as having a Mini Mental State Examination-Japanese score ≤23. Nutritional status was evaluated using the serum albumin level. The fat-free mass index (FFMI) was calculated based on anthropometric and body composition measurements. A logistic regression model with the outcome of a low serum albumin level (serum albumin <4 g/dL) and low FFMI (<16 kg/m2 in men and <14 kg/m2 in women) were used to analyze the data. RESULTS: The percentages of participants in the living alone (-)/cognitive impairment (-) group, the living alone (+)/cognitive impairment (-) group, the living alone (-)/cognitive impairment (+) group, and the living alone (+)/cognitive impairment (+) group were 54.8%, 37.3%, 5.6%, and 2.3%, respectively. Compared to the living alone (-)/cognitive impairment (-) group, the living alone (+)/cognitive impairment (+) group was more likely to have a low serum albumin level (adjusted odds ratio = 3.10, 95% confidence interval = 1.31 to 7.33) and low FFMI (adjusted odds ratio = 2.79, 95% confidence interval = 1.10 to 7.06) after adjusting for potential confounders. CONCLUSION: Cognitively impaired older adults living alone had poorer nutrition than cognitively normal and cohabitating persons in this study. Our results highlight the importance of paying extra attention to nutritional status for this group of community-dwelling older adults.

地域高齢者に潜在する中枢性感作の縦断的検討
橋本 和明; 竹内 武昭; 嶋 美香; 大渕 修一; 河合 恒; 平野 浩彦; 藤原 佳典; 金 憲経; 井原 一成; 渡邊 裕; 端詰 勝敬
Geriatric Medicine, 59, 1, 91, 96, (株)ライフ・サイエンス, Jan. 2021, [Peer-reviewed]
Japanese

地域在住高齢者における口腔機能低下の有訴者率と栄養素等摂取量の関連 後期高齢者の質問票を構成する口腔機能関連項目を用いた検討
釘宮 嘉浩; 本川 佳子; 山本 かおり; 早川 美知; 三上 友里江; 岩崎 正則; 小原 由紀; 白部 麻樹; 枝広 あや子; 渡邊 裕; 大渕 修一; 河合 恒; 解良 武士; 藤原 佳典; 井原 一成; 金 憲経; 平野 浩彦
日本老年医学会雑誌, 58, 1, 91, 100, (一社)日本老年医学会, Jan. 2021, [Peer-reviewed]
Japanese

[The oral function of community-dwelling older adults complaining of an oral function deterioration: An examination using the oral function-related items of the Questionnaire for Latter-stage Elderly People].
Yoshihiro Kugimiya; Masanori Iwasaki; Yuki Ohara; Keiko Motokawa; Ayako Edahiro; Maki Shirobe; Yutaka Watanabe; Shuichi Obuchi; Hisashi Kawai; Takeshi Kera; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Kentaro Igarashi; Daichi Hoshino; Hirohiko Hirano
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 58, 2, 245, 254, 2021, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, AIM: The oral function-related items of the newly developed "Questionnaire for Latter-stage Elderly People" are based on two items of the Kihon checklist assessing the masticatory and swallowing functions. In this study, we estimated the questionnaire's application rate and investigated the oral function of the respondents. METHODS: Included were 699 older adults (274 men/425 women, average age, 73.4±6.6 years old). Those who responded positively to the related items were considered to have decreased swallowing and masticatory functions. The specific oral function was assessed based on the number of present and functional teeth; oral hygiene; oral moisture; occlusal force; oral diadochokinesis /pa/, /ta/, /ka/; tongue pressure; mixing ability; shearing ability; and Eating Assessment Tool (EAT)-10 (reference, score ≥3). RESULTS: The rates of decreased masticatory and swallowing functions were 21.5% and 26.6%, respectively, while 7.4% of participants had both. Those with a decreased masticatory function showed fewer present teeth; a lower occlusal force, oral diadochokinesis /pa/, mixing ability, shearing ability, and higher EAT-10 scores.Those with a decreased swallowing function only had higher EAT-10 scores. In the early- and latter-stage elderly, the decreased masticatory function rates were 15.6% and 29.4%, respectively, the decreased swallowing function rates were 27.8% and 25.0%, respectively, and the rates of both decreased masticatory and swallowing functions were 6.0% and 9.5%, respectively. CONCLUSION: The older adults who responded positively to the related questionnaire items, especially for items related to masticatory function, had a decreased oral function in multiple respects. The items related to the oral function in the Questionnaire for Latter-stage Elderly People are considered useful for identifying older adults with a decreased oral function.

Association between Oral Frailty and Dietary Variety among Community-Dwelling Older Persons: A Cross-Sectional Study.
D Hoshino; H Hirano; A Edahiro; K Motokawa; M Shirobe; Y Watanabe; Y Motohashi; Y Ohara; M Iwasaki; Y Maruoka; Y Yokoyama; M Narita; Y Taniguchi; S Shinkai; A Kitamura
The journal of nutrition, health & aging, 25, 3, 361, 368, 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To examine the association between the severity of oral frailty (OF), which is one of the comprehensive oral functions evaluated, and dietary variety in community-dwelling older persons. DESIGN: Cross-sectional study. SETTING: Community-based. PARTICIPANTS: A total of 769 community-dwelling older persons aged 65 and over. INTERVENTIONS: We examined basic demographic information, functional status, cognitive status, depressive symptoms, medical history, and oral functions of the participants. MEASUREMENTS: OF was defined by 1-2 and 3 or more of 6 items of oral function evaluation in the pre-oral frailty and oral frailty groups, respectively. Dietary variety was assessed using the dietary variety score (DVS). The participants were categorized into 3 groups for evaluation: those with a low score (0-2), medium score (3-5), and high score (≥6). Ordinal logistic regression analysis was performed to examine the association between OF and DVS. RESULTS: The rate of OF in the participants was 21.6%, and its severity was significantly associated with DVS after adjusting for potential confounders (Pre-OF; adjusted odds ratio [OR] = 1.687, 95% confidence interval [CI] = 1.219-2.335, OF; adjusted OR = 2.857, 95% CI = 1.489-5.484). CONCLUSION: The severity of OF was significantly associated with DVS in community-dwelling older persons. This suggests that DVS may be useful in understanding the effects of OF on the nutritional status. Further longitudinal studies are needed to elucidate the association between OF and DVS.

[Relationship between the rate of a decreased oral function and the nutrient intake in community-dwelling older persons: An examination using oral function-related items in a questionnaire for latter-stage elderly people].
Yoshihiro Kugimiya; Keiko Motokawa; Kaori Yamamoto; Misato Hayakawa; Yurie Mikami; Masanori Iwasaki; Yuki Ohara; Maki Shirobe; Ayako Edahiro; Yutaka Watanabe; Shuichi Obuchi; Hisashi Kawai; Takeshi Kera; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Hirohiko Hirano
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 58, 1, 91, 100, 2021, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, AIM: To determine the rate of a decreased oral function using questions from the Kihon checklist corresponding to the Questionnaire for Latter-stage Elderly People and to clarify nutrient intake in older persons. METHODS: This study targeted 511 older people (217 men, 294 women, average age 73.1±5.6 years old). Their oral function was evaluated using questions on the masticatory function and swallowing function from the Kihon checklist, corresponding to questions on the oral function in the Questionnaire for Latter-stage Elderly People. Participants who had at least one symptom measured were defined as the applicable group (AG). In addition, to evaluate the nutrient intake of the participants, interviews were conducted using the Food Frequency Questionnaire Based on Food Groups. RESULTS: The rate of inclusion in the AG was 32.9% for the total sample, 28.2% for early-stage elderly people, and 40.1% for latter-stage elderly people. The AG rates did not differ significantly between men and women. For latter-stage elderly people, the protein-energy ratio and intakes of total energy, protein, pantothenic acid, folic acid, vitamin B6, niacin, vitamin K, copper, zinc, phosphorus, magnesium, potassium, and total dietary fiber were significantly lower in the AG than in the non-AG. CONCLUSION: The evaluation of placement in the AG through questions on the oral function from the Kihon checklist corresponding to the Questionnaire for Latter-stage Elderly People demonstrated that the rate of a decreased oral function was higher in latter-stage elderly people than in early-stage elderly people. In addition, the latter-stage elderly people in the AG had a lower nutrient intake.

A comparison of colorimetric and visual methods for the assessment of masticatory performance with color-changeable chewing gum in older persons.
Yoshihiro Kugimiya; Yutaka Watanabe; Maki Shirobe; Yoshiko Motohashi; Keiko Motokawa; Ayako Edahiro; Yuki Ohara; Masahiro Ryu; Kentaro Igarashi; Daichi Hoshino; Junko Nakajima; Takayuki Ueda; Yu Taniguchi; Toru Ogawa; Kenji Maekawa; Katsushi Tamaki; Takuo Kuboki; Akihiko Kitamura; Shoji Shinkai; Hirohiko Hirano
Journal of dental sciences, 16, 1, 380, 388, Jan. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, Background/purpose: Color-changeable chewing gum is used for the evaluation of masticatory performance. However, it is currently unclear whether colorimetric and visual assessment methods yield consistent results. This study aimed to clarify the consistency between colorimetric and visual methods used for the evaluation of color changes in color-changeable chewing gum. Materials and methods: The sample comprised 644 older persons (mean age, 75.4 ± 6.4 years). The chewing gum was masticated 60 times at the participant's own chewing rate and then expectorated. The color of the chewing gum was evaluated with the ΔE values and a∗ values, measured using a colorimeter, and the 10 Color Shades (10CSh) and 5 Color Scales (5CSc), using visual evaluation. Spearman's correlation analysis was performed to examine the correlation between the results obtained by the four methods. The significance level was set at α = 0.05. Results: The ΔE values, a∗ values, 10CSh scores, and 5CSc scores were all significantly correlated. The highest correlation coefficient (0.979) was between the ΔE values and a∗ values. The lowest correlation coefficient (0.847) was between the a∗ values and 5CSc scores. Decreased masticatory performance was observed with increased age. Conclusion: Significant correlations were found for all four methods used in the assessment of masticatory performance with color-changeable chewing gum. While visually based assessments are valid, colorimetric methods are more sensitive to smaller changes in masticatory performance.

A Two-Year Longitudinal Study of the Association between Oral Frailty and Deteriorating Nutritional Status among Community-Dwelling Older Adults.
Masanori Iwasaki; Keiko Motokawa; Yutaka Watanabe; Maki Shirobe; Hiroki Inagaki; Ayako Edahiro; Yuki Ohara; Hirohiko Hirano; Shoji Shinkai; Shuichi Awata
International journal of environmental research and public health, 18, 1, 30 Dec. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Limited longitudinal studies exist to evaluate whether poor oral health and functions affect the incidence of deteriorating nutritional status. We investigated if there were longitudinal associations between oral frailty, defined as accumulated deficits in oral health, and deteriorating nutritional status among community-dwelling older adults. METHODS: The study population consisted of 191 men and 275 women (mean age, 76.4 years) from the Takashimadaira Study. Multifaced oral health assessment was performed at baseline, and oral frailty was defined as having ≥3 of the following six components: fewer teeth, low masticatory performance, low articulatory oral motor skill, low tongue pressure, and difficulties in chewing and swallowing. Nutritional status assessment was performed at baseline and two-year follow-up using the Mini Nutritional Assessment®-Short Form (MNA®-SF). Deteriorating nutritional status was defined as a decline in the nutritional status categories based on the MNA®-SF score during the study period. The association between oral frailty and deteriorating nutritional status was assessed using logistic regression analyses. RESULTS: Oral frailty was observed in 67 (14.4%) participants at baseline. During the study, 58 (12.4%) participants exhibited deteriorating nutritional status. After adjusting for potential confounders, oral frailty was significantly associated with deteriorating nutritional status (adjusted odds ratio, 2.24; 95% confidence interval, 1.08-4.63). CONCLUSION: Community-dwelling older adults with oral frailty had an increased risk of deteriorating nutritional status.

半夏厚朴湯による歯科心身症の治療効果に関連する因子の研究 Cornell Medical Indexを用いた検討
新井 絵理; 三浦 和仁; 平良 賢周; 尾崎 公哉; 渡邊 裕; 山崎 裕
日本歯科心身医学会雑誌, 35, 1-2, 20, 25, (一社)日本歯科心身医学会, Dec. 2020, [Peer-reviewed]
Japanese, 歯科心身症に対し半夏厚朴湯が投与された症例の治療効果を、身体的自覚症状と精神的自覚症状を213問により詳細に評価するCMI(Cornell Medical Index健康調査表)との関連から明らかにすることを目的に、2013年8月〜2018年9月に当院(大学病院歯科診療センター)高齢者歯科で治療を行った歯科心身症患者で、治療前にCMIが施行され半夏厚朴湯エキス顆粒(5.0g/日)を2週間以上服用し、その治療効果が診療録から判定可能であった女性患者29例(平均年齢61.8±10.7歳)を対象に検討した。半夏厚朴湯の効果判定は、服用開始前に比べ自覚症状のVASが半分以下に低下した者を有効、その他を無効とし、両群のCMIの項目(設問)との関連を統計学的に分析した。その結果、有効群14例(48%)、無効群15例(52%)で、原疾患別では舌痛症は9/15例(60%)と比較的良好であったが、従来から半夏厚朴湯がよく使用されている口腔内異常感症については、有効例はなかった(0/4例)。一方、CMIによる検討では、胃の調子が悪い患者や、家族に精神科病院の入院既往を有する患者で、半夏厚朴湯の効果が有意に高かった。

聴神経腫瘍術後の後遺症に心因性が加重された難治性味覚障害の1例
三浦 和仁; 新井 絵理; 平良 賢周; 尾崎 公哉; 渡邊 裕; 山崎 裕
日本歯科心身医学会雑誌, 35, 1-2, 41, 44, (一社)日本歯科心身医学会, Dec. 2020, [Peer-reviewed]
Japanese, 聴神経腫瘍術後の味覚障害に対し、薬物療法と簡易精神療法を行うことで、一進一退を繰り返す長期経過を経て、最終的に完治が得られた症例(60代男性)について報告した。当初、術後の後遺症による味覚障害と考えたが、術後1年を経ても改善がみられず、患者が今回の手術を機に早期退職し、気持ちが落ち込むと話していたことから、術後の後遺症に心因性が加重したものと考えた。そこで、当科で心因性と特発性の味覚障害に頻用しているロフラゼプ酸エチルなどの投与を開始したが効果はみられず、一時的な改善がみられた小柴胡湯を経て、ミルナシプランへの変更により、徐々に味覚の改善が得られた。これには、ミルナシプランの効果だけでなく、趣味の野球観戦や登山に出かけることを推奨し、患者が積極的に行動できるようになったのも奏功したと考えた。併せて、患者自らが、食事の味がしなくても食事後には美味しかった有難うと感謝の言葉を口にするといった行動療法を自発的に実践することで、味覚異常は徐々に軽快し、初診から5年後、味覚異常のVASは3とほぼ完治が得られ、さらにその後、完全に回復した。

支持的精神療法が口腔異常感症の早期寛解に有効であった1例
平良 賢周; 三浦 和仁; 新井 絵理; 尾崎 公哉; 渡邊 裕; 山崎 裕
日本歯科心身医学会雑誌, 35, 1-2, 45, 48, (一社)日本歯科心身医学会, Dec. 2020, [Peer-reviewed]
Japanese, 口腔異常感(ヌルヌル感)を訴える患者(70代女性、10数年前に夫と死別し、以後独居)に、漢方薬(半夏瀉心湯)を用いた薬物療法と支持的精神療法による加療を行った結果、早期に症状の改善を認めた症例について報告した。1回目の受診で、漢方の処方に加え、「口の中は非常に敏感で、体や心の小さな変化が契機となって口腔に症状として現れやすい」ことを説明し、患者の口腔異常感への理解と不安の解消に努めた。2回目の受診では、口腔内の不快感を示すVASは、初診時の100から50へと半減しており、患者には唾液の分泌が十分に保たれ、口腔や全身の健康に好ましい状態であると説明するとともに、新たに、口腔内の症状に関して感じたことを毎日、日記に記すよう指示した。1ヵ月後の4回目の受診では、日記に「口内のヌルヌル感は多い日と全然気にならない日がある。これは一寸したことが気になりだした時、量が多い」と記されており、口腔内のヌルヌル感は完全に消失していないものの、症状を受容しながら日常生活を支障なく送れるようになっていた。口腔内の不安感を示すVASは初診時の100から0となっており、患者も「今後は通院しなくても、自分自身で口腔の異常感に対応できる」と自信がもてるようになったことから、当科終診とした。

当科における高齢者味覚障害患者の臨床的検討
松下 貴惠; 岩島 佑希; 馬場 陽久; 稲本 香織; 三浦 和仁; 岡田 和隆; 渡邊 裕; 山崎 裕
老年歯科医学, 35, 3, 209, 217, (一社)日本老年歯科医学会, Dec. 2020, [Peer-reviewed]
Japanese

Development of a simple method to measure masseter muscle mass.
Masaharu Murakami; Katsuya Iijima; Yutaka Watanabe; Tomoki Tanaka; Yasuyuki Iwasa; Ayako Edahiro; Yuki Ohara; Keiko Motokawa; Maki Shirobe; Hirohiko Hirano
Gerodontology, 37, 4, 383, 388, Dec. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To develop a simple method to estimate masseter muscle mass. BACKGROUND: The masseter muscle is important for optimal oral function. A decrease in the masseter muscle mass may affect the oral and physical function of the whole body; therefore, it is an important entity to measure. However, to date, no easy measurement method has been developed for the same. Herein, we devised a simple method to estimate masseter muscle mass. In addition, we compared our method with magnetic resonance imaging (MRI) and skeletal muscle mass (SMM) to verify its validity. MATERIALS AND METHODS: We recorded the age, sex, masseter muscle mass (by MRI), number of retained natural teeth, number of functional teeth, length and thickness of masseter muscle, and skeletal muscle mass in 53 community-dwelling elderly people (21 men and 32 women, average age 72.9 ± 4.5 years). The estimated masseter muscle mass was calculated by multiplying the length, width and thickness of the muscle. RESULTS: The correlation coefficient between masseter muscle mass and estimated masseter muscle mass was r = .903; thus, a strong correlation was recognised. The correlation coefficient between the estimated masseter muscle mass and SMM was r = .279, considering age and sex. CONCLUSION: We obtained substantial results using our method for estimating the masseter muscle mass and verified its validity by comparing it with masseter muscle mass measured by MRI and SMM. We believe that our proposed technique is simple and useful for estimating masseter muscle mass.

Association between anorexia and hyposalivation in community-dwelling older adults in Japan: a 6-year longitudinal study.
Yuki Ohara; Hisashi Kawai; Maki Shirobe; Keiko Motokawa; Yoshinori Fujiwara; Hunkyung Kim; Kazushige Ihara; Shuichi Obuchi; Ayako Edahiro; Masanori Iwasaki; Yutaka Watanabe; Hirohiko Hirano
BMC geriatrics, 20, 1, 504, 504, 25 Nov. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Hyposalivation is associated with the nutritional status. Anorexia of ageing, defined as an age-related decrease in appetite and food intake, presents even in healthy adults and is considered an independent predictor of malnutrition, frailty, and mortality. However, the relationship between anorexia and hyposalivation of ageing is unclear. Thus, the present longitudinal study aimed to investigate the incidence of hyposalivation and its relationship with anorexia in community-dwelling older people in Japan. METHODS: The study population comprised 220 individuals (80 men and 140 women) aged 65-86 years at baseline. The participants underwent comprehensive health check-ups, including dental examinations and anthropometry, and face-to-face interviews in 2013 and 2019. Hyposalivation was determined on the basis of the unstimulated salivary flow rate measured using the modified cotton roll method. Anorexia was defined as a score of ≤29 in the Japanese version of the Council on Nutrition Appetite Questionnaire. Logistic regression analyses were used to test whether the presence of anorexia at baseline was an independent predictor of hyposalivation. RESULTS: Hyposalivation developed at a rate of 19.5% during the 6-year observation period. Anorexia was observed in 95 (43.2%) participants at baseline. After adjusting for potential confounding factors, anorexia (adjusted odds ratio [AOR], 2.65; 95% confidence interval [CI], 1.26-5.57) and polypharmacy (AOR, 3.29; CI, 1.06-10.19) were significant predictors of hyposalivation. CONCLUSION: Loss of appetite is independently correlated with and a risk factor for hyposalivation in older adults. Anorexia of ageing may have negative effects on the salivary flow rate in such settings. Salivation should be a standard feature in clinical assessments of the older adults.

Continued smoking and posterior vitreous adhesion in the elderly evaluated on swept-source optical coherence tomography.
Taku Toyama; Yohei Hashimoto; Hisashi Kawai; Kunihiro Azuma; Tomoyasu Shiraya; Fumiyuki Araki; Koichiro Sugimoto; Yutaka Watanabe; Hirohiko Hirano; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Satoshi Kato; Jiro Numaga; Shuichi Obuchi; Takashi Ueta
Scientific reports, 10, 1, 18460, 18460, 28 Oct. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, In this cross-sectional study including 1150 eyes of 681 volunteers ≧ 65 years old without retinal pathology, factors affecting the progression of posterior vitreous detachment (PVD) were investigated. PVD stages were diagnosed based on swept-source optical coherence tomography (SS-OCT). Linear mixed effect model was used to determine whether age, gender, diabetes mellitus (DM), hypertension (HT), dyslipidemia (DL), and smoking status were associated with various stages of PVD. As a result, the multivariable analysis disclosed that the associations between older age and higher PVD stages (estimate [95% CI], 0.031 [0.020 to 0.042]; P < 0.0001), and current smokers and lower PVD stages (estimate [95% CI], - 0.24 [- 0.43 to - 0.056]; P = 0.011) were statistically significant. In contrast, female gender was not an independent factor affecting PVD stages in the elderly. Our analysis indicated that higher PVD stages observed in female eyes may be due to confounding effect, in which current smokers were predominantly males (i.e., 12.6% among males vs. 3.9% among females, P < 0.0001). In conclusion, our findings suggest that continuous smoking is associated with an adherent vitreoretinal interface in the elderly.

Effect of oral health intervention on cognitive decline in community-dwelling older adults: A randomized controlled trial.
Chiaki Matsubara; Maki Shirobe; Junichi Furuya; Yutaka Watanabe; Keiko Motokawa; Ayako Edahiro; Yuki Ohara; Shuichi Awata; Hunkyung Kim; Yoshinori Fujiwara; Shuichi Obuchi; Hirohiko Hirano; Shunsuke Minakuchi
Archives of gerontology and geriatrics, 92, 104267, 104267, 28 Sep. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: The incidence of dementia is rapidly increasing worldwide, especially in developed countries. Little is known regarding the effectiveness of dental intervention to prevent dementia or a decline in cognitive functions among community-dwelling older adults, but a few studies have reported a correlation between the lack of regular dental checkups and dementia. For that reason, this study aimed to investigate the effects of oral health intervention on cognitive functions in community-dwelling subjects with a mild cognitive decline via a randomized controlled trial. PATIENTS AND METHODS: Fifty-five community-dwelling older adults with a Mini-Mental State Examination score of ≥21 to ≤26 who had not visited a dental clinic in the previous year were randomized to an intervention group (n = 28) or a control group (n = 29). The intervention group received monthly oral health intervention by dental hygienists for 8 months while the control group did not. Data on demographics, cognitive function and oral parameters were collected before and after the intervention. RESULTS: Twenty-five subjects in the intervention group (mean age 77.0 years) and 25 in the control group (mean age 72.8 years) completed the study. Significant improvements were observed in the Trail Making Test (TMT)-A, TMT-B, bleeding on probing rate, oral diadochokinesis, tongue pressure and chewing ability in the intervention group (P < 0.05). There were also significant interactions between the TMT-A and TMT-B scores, oral diadochokinesis, tongue pressure and chewing ability (P < 0.05). CONCLUSION: Oral health intervention by dental hygienists may be effective for improving the oral health and executive function of cognitive function assessed via TMT.

Cross-sectional study of age-specific differences in salivary occult blood test results in older adults.
Chiaki Matsubara; Junichi Furuya; Yutaka Watanabe; Michiyo Obana; Maki Shirobe; Yuki Ohara; Ayako Edahiro; Junko Nakajima; Keiko Motokawa; Hiroki Inagaki; Hirohiko Hirano; Shunsuke Minakuchi; Shoji Shinkai; Shuichi Awata
Journal of oral science, 62, 4, 410, 414, 26 Sep. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, This study aimed to identify factors associated with poor oral health status, as indicated by salivary occult blood (SOB) level, in community-dwelling older adults. A total of 592 community-dwelling participants aged 70 to 84 years with 20 to 28 teeth participated in the survey and SOB evaluation. Survey items included behaviors during dental visits, systemic diseases, smoking habit, cognitive function, and findings of intraoral examination. To identify factors associated with high SOB levels, binomial logistic regression analysis was performed after classifying participants as having high and low SOB on the basis of 75th-percentile SOB measurements. Presence of dental plaque (odds ratio [OR]: 2.26), poor subjective oral health (OR: 2.99) (for the age group 70 to 74 years), fewer remaining teeth (OR: 0.80), no dental visits during the previous year (OR: 2.80) (for the age group 75 to 79 years), and no dental visits during the previous year (OR: 3.93) (for the age group 80 to 84 years) were significantly associated with high SOB levels. The factors associated with high SOB, which indicates poor oral health status, differed by age group in community-dwelling older adults. Therefore, oral health management may improve oral health by providing different age groups with care that accounts for their physical and social functional abilities.

A combined stepping and visual tracking task predicts cognitive decline in older adults better than gait or visual tracking tasks alone: a prospective study.
Yosuke Osuka; Hunkyung Kim; Yutaka Watanabe; Yu Taniguchi; Narumi Kojima; Satoshi Seino; Hisashi Kawai; Ryota Sakurai; Hiroki Inagaki; Shuichi Awata; Shoji Shinkai
Aging clinical and experimental research, 33, 7, 1865, 1873, 23 Sep. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: It is unclear whether motor-cognitive dual tasks predict cognitive decline better than either motor or cognitive tasks alone. AIMS: To examine the utility of the novel motor-cognitive dual-task test [Stepping Trail Making Test (S-TMT)], as a predictor of cognitive decline, and compare its predictive performance with single motor or cognitive tests. METHODS: This 2-year population-based prospective study included 626 adults aged ≥ 70 years from Takashimadaira, Itabashi, Tokyo. The S-TMT measured the time taken to step on 16 numbers in order. Gait speed and TMT-A were assessed with standardized methods as single motor and cognitive tasks, respectively. A decline in the Mini-Mental State Examination score by ≥ 3 points over 2 years was defined as a significant cognitive decline. RESULTS: Over 2 years, 97 (15.5%) experienced cognitive decline. After adjusting for confounders, binary logistic regression models showed no significant associations between gait speed, TMT-A time tertiles, and risk of cognitive decline, but participants in the longest tertile of S-TMT time were more likely to develop cognitive decline than those of the shortest tertile (odds ratio 2.14; 95% confidence interval 1.17-3.90). Only the addition of the S-TMT time to the covariates model significantly improved the reclassification indices for predicting cognitive decline (net reclassification improvement: 0.31, P < 0.01; integrated discrimination improvement: 0.01, P = 0.02). DISCUSSION AND CONCLUSION: Only the S-TMT was significantly associated with cognitive decline and improved reclassification indices, indicating that it is more useful for predicting cognitive decline than individual gait speed or visual tracking tests alone.

A Stepping Trail Making Test as an Indicator of Cognitive Impairment in Older Adults.
Yosuke Osuka; Hunkyung Kim; Yutaka Watanabe; Yu Taniguchi; Narumi Kojima; Satoshi Seino; Hisashi Kawai; Ryota Sakurai; Hiroki Inagaki; Shuichi Awata; Shoji Shinkai
Journal of clinical medicine, 9, 9, 02 Sep. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, This study aimed to examine the concurrent validity of a novel motor-cognitive dual-task test, the Stepping Trail Making Test (S-TMT), as an indicator of cognitive impairment (CI), and compare its screening performance to that of motor or cognitive tests alone. This was a population-based cross-sectional study including 965 Japanese adults aged ≥ 70 years. To measure the time taken to perform the S-TMT, the participants were instructed to step on 16 numbers in sequence as quickly and accurately as possible. Motor and cognitive functions were assessed by gait speed and TMT part A (TMT-A), respectively. Participants were classified into CI (< 24 points), mild CI (MCI, 24-27 points), and intact cognition (> 27 points) categories based on their Mini-Mental State Examination score. Binary logistic regression models showed that the addition of the S-TMT to the covariates model gave the highest discrimination index (c-statistics), and significantly improved reclassification indices (net reclassification improvement and integrated discrimination improvement) for screening both CI and MCI compared to those of gait speed or TMT-A alone. These results show that S-TMT has a concurrent validity as a dual-task test for screening CI and MCI and better discrimination and reclassification performance than motor or cognitive tests alone in older adults.

様々な対応により改善した特発性味覚障害の1例
三浦 和仁; 大西 香織; 新井 絵理; 松下 貴惠; 岡田 和隆; 渡邊 裕; 山崎 裕
北海道歯学雑誌, 41, 1, 46, 51, 北海道歯学会, Sep. 2020, [Peer-reviewed]
Japanese

Association between ground reaction force in sit-to-stand motion and falls in community-dwelling older Japanese individuals.
Takeshi Kera; Hisashi Kawai; Junta Takahashi; Hirohiko Hirano; Yutaka Watanabe; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Shuichi Obuchi
Archives of gerontology and geriatrics, 91, 104221, 104221, 06 Aug. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Ground reaction force (GRF) during sit-to-stand motion is associated with lower extremity strength and balance function. The relationship between GRF and experience of falls has been reported; however, there are no reports on whether GRF can predict the incidence of future falls. We aimed to evaluate the ability of GRF to predict falls and compare GRF with existing predictors. METHODS: This prospective observational cohort study enrolled 456 community-dwelling older adults living in Itabashi ward who participated in health check-ups in 2016 and 2017. Participants' physical and cognitive functions were assessed, and the maximum GRF (F), F/weight (F/W), rate of force development (RFD), RFD/W (RFD/weight), and time taken to stand up were evaluated. The following year, participants were asked to report the number of falls during the year. Cox proportional hazards regression was conducted to analyze the relationship between the lowest quintile of each GRF parameter as a predictive factor for falling and assess the annual incidence of falls. RESULTS: Twenty-three participants reported having two or more falls in the previous year. Of all GRF parameters evaluated, only F/W was lower in the fallers than in the non-fallers. After adjusting for sex, age, lifestyle, and comorbidities, F/W was associated with falls in 1 year, and the lowest F/W group had higher risks of falls than the highest F/W group (hazard ratio 2.72, 95 % confidence interval 1.11-6.68). Other measures were not associated with falls. CONCLUSIONS: GRF during the sit-to-stand motion might predict the incidence of future falls.

Factors related to removable denture use in independent older people: A cross-sectional study.
Yohei Hama; Chieko Kubota; Shingo Moriya; Rie Onda; Yutaka Watanabe; Shunsuke Minakuchi
Journal of oral rehabilitation, 47, 8, 998, 1006, Aug. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Denture use for recovery of major tooth loss can reduce the need for care, and thus, it is important for dentists to identify the types of patients who use removable dentures. OBJECTIVE: To identify factors associated with removable denture use in independent older Japanese people. METHODS: This cross-sectional study investigated the oral condition; demographics; lifestyle; dental visit behaviour; and higher-level functional capacity, as assessed using the Tokyo Metropolitan Institute of Gerontology index of competence (TMIG index), of independent older people aged 65-74 years. Participants were divided into four groups based on sex and condition of the posterior occluding pairs (POPs). Multivariate-adjusted logistic regression analyses were performed for each group, with denture use or non-use as the dependent variable and the other items as independent variables. RESULTS: Denture use or non-use was significantly associated with only dental consultation behaviour (regular dental visits and time since the last dental visit) in all groups. Subsequent analyses excluding dental consultation behaviour demonstrated that denture use or non-use was significantly associated with educational background in female participants with decreased POPs, with the type of household in male participants with lost POPs and with the TMIG index (social role) in female participants with lost POPs. CONCLUSIONS: Denture use was associated with dental consultation behaviour. We revealed factors related to denture use or non-use in females with decreased POPs and both males and females with lost POPs.

地域包括ケアシステムのフォローアップならびに情報共有化に向けた取り組みに関する調査報告
伊藤 加代子; 梅本 丈二; 渡部 芳彦; 岩佐 康行; 渡邊 裕; 米山 武義; 金久 弥生; 石黒 幸枝; 有松 ひとみ; 金子 信子; 本川 佳子; 下山 和弘; 櫻井 薫; 佐藤 裕二; 日本老年歯科医学会多職種連携委員会
老年歯科医学, 35, 1, 29, 40, (一社)日本老年歯科医学会, Jun. 2020, [Peer-reviewed]
Japanese, 2018年5月に日本老年歯科医学会の会員3636名に電子メールでアンケートを依頼し、地域包括ケアシステムへの関わりや訪問歯科診療の実施状況などについて調査した。340名から有効回答が得られ、地域包括ケアシステム(A)という言葉を「聞いたことがある」と答えた割合は97%、Aについて「説明できる」と答えたのは75%、Aに「関わりたい」と答えたのは48%、「関わっている」と答えたのは37%であった。訪問歯科診療の経験が「ある」と答えたのは79%、歯科衛生士単独での訪問歯科衛生指導を「実施している」と答えたのは37%、経口維持加算IIにおけるミールラウンドに参加したことが「ある」と答えたのは30%であった。Aに関する意見を自由記述してもらいKJ法で分析した結果、「システム」「情報発信」に関する意見が最も多く各15件、次いで「連携強化」11件、「意識」4件、「教育」3件、「知識・理解」2件の順であった。訪問歯科診療に関する意見を自由記述してもらいKJ法で分析した結果、「歯科関係者や歯科関係組織の問題・改善策」に関するものが最も多く43件、次いで「制度の問題・要望・改善案」28件、「訪問歯科診療実施上の課題」24件、「多職種連携の課題」19件の順であった。

Oral health for achieving longevity.
Yutaka Watanabe; Kazutaka Okada; Miyako Kondo; Takae Matsushita; Seitaro Nakazawa; Yutaka Yamazaki
Geriatrics & gerontology international, 20, 6, 526, 538, Jun. 2020, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
English, Scientific journal, Oral frailty is defined as a decrease in oral function accompanied by a decrease in mental and physical functions. Studies showing that people with oral frailty are at high risk of physical frailty, sarcopenia, severe conditions requiring nursing care and death have been reported in Japan. An increase in life expectancy and maintenance of teeth result in a decrease in the effect of the number of teeth. In contrast, a decrease in oral function as a result of aging has been suggested to have major effects on dysfunction and mortality risk. The present report is a narrative review of major clinical studies on the relationships of the number of teeth, dentures, occlusion and oral function with longevity, with the aim of providing information for future studies centered on oral function in Japan or overseas. This review clearly shows the relationships of the number of teeth, dentures, and occlusion with health and longevity. Recent studies have shown that, besides maintenance of the number of teeth, attempting to maintain or increase oral function, having a good diet and maintaining nutritional status are all linked to general health. Decreased oral function is a major risk factor for developing malnutrition and sarcopenia. Oral frailty, a new concept that has been recently introduced in Japan, is considered to have major effects on dental and oral health policies in Japan, in the old-age group, and is expected to be reflected in the dental and oral health policies of various countries, as they also predict increased life expectancies. Geriatr Gerontol Int 2020; ••: ••-••.

Number of functional teeth more strongly predicts all-cause mortality than number of present teeth in Japanese older adults.
Kenji Maekawa; Tomoko Ikeuchi; Shoji Shinkai; Hirohiko Hirano; Masahiro Ryu; Katsushi Tamaki; Hirofumi Yatani; Takuo Kuboki; Aya Kimura-Ono; Takeshi Kikutani; Takashi Suganuma; Yasunori Ayukawa; Tomoya Gonda; Toru Ogawa; Masanori Fujisawa; Shoichi Ishigaki; Yutaka Watanabe; Akihiko Kitamura; Yu Taniguchi; Yoshinori Fujiwara; Ayako Edahiro; Yuki Ohara; Junichi Furuya; Junko Nakajima; Kento Umeki; Kentaro Igarashi; Yasuhiro Horibe; Yoshihiro Kugimiya; Yasuhiko Kawai; Hideo Matsumura; Tetsuo Ichikawa; Shuji Ohkawa
Geriatrics & gerontology international, 20, 6, 607, 614, Jun. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: Previous studies on the association between intraoral conditions and mortality in community-dwelling older individuals reported that fewer present teeth (PT) are significant risk factors for mortality. However, how the number of PT relative to the number of functional teeth (FT), including both present and rehabilitated teeth, influences mortality has not been investigated fully. This study examined the impact of the number of FT on mortality among community-dwelling Japanese older adults. METHODS: This study was a retrospective, observational and population-based follow-up study, which examined 1188 older individuals who participated in an annual geriatric health examination from 2009 to 2015. The average follow-up period was 1697.0 ± 774.5 days. The primary outcome was all-cause mortality at follow-up. The numbers of PT and FT of each participant were counted during an oral examination. In addition, demographics, clinical variables, blood nutrient markers, physical functions and perceived masticatory function were measured. RESULTS: Kaplan-Meier analysis, followed by a log-rank test, revealed that fewer PT (P < 0.001) and FT (P = 0.002) were significantly associated with a reduced survival rate. Cox's proportional hazard analysis indicated that the number of FT, but not the number of PT, was a significant independent mortality risk factor after adjusting for demographics, clinical variables, nutrient markers and physical functioning (P = 0.036, hazard ratio: 2.089). CONCLUSIONS: Current results suggest that the number of FT more strongly predicts all-cause mortality than the number of PT among community-dwelling older adults. Further studies are necessary to consider the confounding of socioeconomic status and disability status. Geriatr Gerontol Int 2020; ••: ••-••.

Association between oral, social, and physical frailty in community-dwelling older adults.
Sanae Hironaka; Yoshihiro Kugimiya; Yutaka Watanabe; Keiko Motokawa; Hirohiko Hirano; Hisashi Kawai; Takeshi Kera; Motonaga Kojima; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Shuichi Obuchi; Yasuaki Kakinoki
Archives of gerontology and geriatrics, 89, 104105, 104105, Elsevier BV, 16 May 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, OBJECTIVES: Oral frailty (OF) has been shown to be a predictor of disability. Therefore, it is important to be able to identify factors associated with OF in order to prevent long-term dependence. The purpose of this study was to clarify the relationships between OF, social frailty (SF), and physical frailty (PF) in community-dwelling older adults, with the overarching aim of informing the future development of effective measures to prevent frailty. METHODS: Oral, physical, and social function, nutritional and psychological status, and medical history were examined in 682 community-dwelling individuals (267 men, 415 women) aged ≥ 65 years. Ordinal logistic regression analysis with SF and PF as independent variables was performed with pass analysis to determine the relationship between the different types of frailty. RESULTS: Logistic regression analysis revealed significant associations between OF and decline in social function, physical function, and nutritional status, and an increase in the number of medications used. Path analysis showed that SF was directly related to OF and that OF and SF were directly related to PF. CONCLUSIONS: These findings suggest that a decline in social function may directly influence a decline in oral and physical function. The results of this study provide initial evidence, that may guide the future development of measures that aim to prevent and manage OF.

Association of eating alone with depression among older adults living alone: Role of poor social networks.
Ryota Sakurai; Hisashi Kawai; Hiroyuki Suzuki; Hunkyung Kim; Yutaka Watanabe; Hirohiko Hirano; Kazushige Ihara; Shuichi Obuchi; Yoshinori Fujiwara
Journal of epidemiology, 18 Apr. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, OBJECTIVES: Eating alone is associated with an increased risk of depression symptoms. This association may be confounded by poor social networks. The present study aimed to determine the role of poor social networks in the association of eating alone with depression symptoms, focusing on cohabitation status. METHODS: Seven hundred and ten community-dwelling older adults were categorised according to their eating style and social network size, evaluated by an abbreviated version of the Lubben Social Network Scale, with poor social network size defined as the lowest quartile. Living arrangements and depression symptoms, detected by the Zung Self-Rating Depression Scale, were also assessed. RESULTS: A mixed-design two-way ANCOVA (eating style and social network size factors) for the depression scale score, adjusted by covariates, yielded significant effects of social network size and eating style without interaction. Greater depression scores were observed in eating alone and poor social network size. Analysis of participants living with others showed the same results. However, among older adults living alone, only a significant main effect of social network size was observed; poor social network size resulted in greater depression scores irrespective of eating style. CONCLUSIONS: Poor social network size, and not eating alone, was associated with greater depression symptoms among older adults living alone, whereas both factors may increase depression symptoms among older adults living with others. Poor social network size may show a stronger influence on depression than eating alone in older adults living alone; thus, social network size is an important health indicator.

Association between Daily Living Walking Speed and Walking Speed in Laboratory Settings in Healthy Older Adults.
Hisashi Kawai; Shuichi Obuchi; Yutaka Watanabe; Hirohiko Hirano; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Yoshiyuki Kobayashi; Masaaki Mochimaru; Eiki Tsushima; Kozo Nakamura
International journal of environmental research and public health, 17, 8, 15 Apr. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Although there is evidence on the predictors of adverse health outcomes in older individuals, walking speed has typically been measured in laboratory settings (LWS); LWS may be distinct from individuals' actual walking speed in their daily lives (DWS). We examined whether DWS differs from LWS among older adults, and its association with physical frailty. Participants were 90 community-dwelling older adults. A five-meter normal (LWSnor) and maximum (LWSmax) walking speed was measured with a stopwatch. DWS was measured using a global positioning system-related smartphone application for one month during their daily lives. DWSavr, DWSmax, and DWSsd were defined as the average, maximum, and standard deviation of walking speed for one month. Participants' mean DWSavr and DWSmax were 1.28 m/s and 2.14 m/s, respectively, significantly slower than the mean LWSnor (1.42 m/s) and LWSmax (2.24 m/s); the intraclass correlation coefficient between DWS and LWS were 0.188 to 0.341. DWS was significantly correlated with grip strength, one-legged stance, and LWS. The area under the receiver operating characteristic curve of DWSsd concerning pre-frailty was largest among DWSs, at 0.615, while that of LWSnor was 0.643. The findings suggest that DWS differs from LWS and is associated with physical function and pre-frailty.

論文作成に必要な知識 症例報告と観察研究論文に記載すべき事項
渡邊 裕; 新井 伸征; 青柳 陽一郎; 加賀谷 斉; 菊谷 武; 小城 明子; 柴本 勇; 清水 充子; 中山 剛志; 西脇 恵子; 野本 たかと; 平岡 崇; 深田 順子; 古屋 純一; 松尾 浩一郎; 山本 五弥子; 山本 敏之; 花山 耕三
日本摂食・嚥下リハビリテーション学会雑誌, 24, 1, 77, 89, (一社)日本摂食嚥下リハビリテーション学会, Apr. 2020
Japanese

Reliability and construct validity of a novel motor-cognitive dual-task test: A Stepping Trail Making Test.
Yosuke Osuka; Narumi Kojima; Ryota Sakurai; Yutaka Watanabe; Hunkyung Kim
Geriatrics & gerontology international, 20, 4, 291, 296, Apr. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: This study aimed to examine the reliability and construct validity of the Stepping Trail Making Test (S-TMT) in community-dwelling older adults. METHODS: This study comprised a cross-sectional study based on a population sample. Participants comprised 1224 community-dwelling older Japanese women aged 65-81 years without functional disability, dementia, depression, Parkinson's disease, or cognitive and visual impairments. The S-TMT measured the time taken to step on a sequence of numbers (1-16) positioned on a mat (1 m2 ). Participants were instructed to step as quickly and accurately as possible. Motor functions were assessed by walking speed and knee extensor strength tests, while cognitive functions were assessed by the Symbol Digit Substitution Task (SDST) test, verbal and logical memory test, and TMT-A and -B. RESULTS: As a result of test-retest reliability over 6 months, the intraclass correlation coefficients of the S-TMT was 0.82 (95% confidence interval, 0.68-0.90). An adjusted multiple regression model indicated that the S-TMT was significantly associated with walking speed for motor function, and associated with the SDST, TMT-A and TMT-B for cognitive functions (P < 0.001). CONCLUSIONS: These results suggest that the S-TMT is a reliable dual-task test comprising mobility for motor function and a visual-dependent execution function for cognitive function in older women. Geriatr Gerontol Int 2020; 20: 291-296.

Reliability and Validity of the Activity Diversity Questionnaire for Older Adults in Japan.
Junta Takahashi; Hisashi Kawai; Hiroyuki Suzuki; Yoshinori Fujiwara; Yutaka Watanabe; Hirohiko Hirano; Hunkyung Kim; Kazushige Ihara; Kaori Ishii; Koichiro Oka; Shuichi Obuchi
International journal of environmental research and public health, 17, 7, 31 Mar. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Recent research has suggested that the breadth and evenness of activity and activity diversity contribute to health outcomes among older adults. However, few established assessment tools for activity diversity have been developed. This study developed an Activity Diversity Questionnaire (ADQ) for older adults through expert consultation and a preliminary survey among 18 community-dwelling older adults. The diversity score was calculated according to Shannon's entropy. In study 1, the intraclass correlation coefficients (ICC) of the diversity scores were determined for community-dwelling older adults (n = 30). In study 2, concurrent validity was tested with participants receiving comprehensive health checkups at the Itabashi ward in Japan in 2018 (n = 766). The correlation coefficients of the diversity scores were then calculated in reference to the Tokyo Metropolitan Institute of Gerontology Index of Competence and Japan Science and Technology Agency Index of Competence. The final version of the ADQ consisted of 20 total items with excellent test-retest reliability (ICC = 0.84) and moderate correlations with both the Tokyo Metropolitan Institute of Gerontology Index of Competence and Japan Science and Technology Agency Index of Competence (r = 0.48 and 0.60, respectively). The ADQ was developed through scientific procedures and revealed sufficient reliability and validity. As such, it is a scientifically validated tool for assessing activity diversity among older adults.

Rate of oral frailty and oral hypofunction in rural community-dwelling older Japanese individuals.
Yoshihiro Kugimiya; Yutaka Watanabe; Takayuki Ueda; Keiko Motokawa; Maki Shirobe; Kentaro Igarashi; Daichi Hoshino; Tomofumi Takano; Kaoru Sakurai; Yu Taniguchi; Akihiko Kitamura; Shoji Shinkai; Hirohiko Hirano
Gerodontology, 37, 4, 342, 352, 06 Mar. 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, OBJECTIVE: To clarify the rate of oral frailty and oral hypofunction in rural community-dwelling older adults in Japan. BACKGROUND: Recently, the oral function of Japanese older adults has been evaluated multilaterally based on two concepts: oral frailty and oral hypofunction. Oral frailty is defined as a decrease in the oral function accompanied by a decrease in mental and physical functions. Oral hypofunction is a disease where the oral function is comprehensively decreased. However, their rates have not yet been elucidated. MATERIALS AND METHODS: Oral frailty and oral hypofunction were evaluated in 679 older adults from rural areas. To investigate the differences in occurrence rates due to the evaluation methods, one of the subordinate symptoms of oral hypofunction, the reduced occlusal force, was evaluated based on both the occlusal force (main method) and the number of teeth (alternative method). RESULTS: The rate of oral frailty was 22.3% in men and 22.7% in women. The rate of oral hypofunction was 39.0% in men and 46.9% in women. The overall rate of oral hypofunction was 43.6% when the reduced occlusal force of oral hypofunction was evaluated using the main method and 46.4% when evaluated using the alternative method. The proportion of participants with decreased occlusal force, the number of present teeth, oral diadochokinesis, tongue pressure and masticatory performance increased with age in both men and women. CONCLUSION: Among rural community-dwelling older adults, the rate of oral frailty was 22.5% and that of oral hypofunction was 43.6%.

要介護者の肺炎予防に向けた舌圧測定の有用性ならびに新たな口腔機能評価法の開発
吉田 光由; 吉川 峰加; 津賀 一弘; 菊谷 武; 渡邊 裕; 松尾 浩一郎; 上田 貴之; 櫻井 薫
日本歯科医学会誌, 39, 44, 49, 日本歯科医学会, Mar. 2020, [Peer-reviewed]
Japanese

Development and validity of the Computer-Based Cognitive Assessment Tool for intervention in community-dwelling older individuals.
Junta Takahashi; Hisashi Kawai; Hiroyuki Suzuki; Yoshinori Fujiwara; Yutaka Watanabe; Hirohiko Hirano; Hunkyung Kim; Kazushige Ihara; Akiko Miki; Shuichi Obuchi
Geriatrics & gerontology international, 20, 3, 171, 175, Wiley, Mar. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: The Mini-Mental State Examination is a widely used cognitive assessment tool. However, it has several limitations, including the learning effect and interrater reliability. Therefore, we developed a Computer-Based Cognitive Assessment Tool (CompBased-CAT), which runs on a tablet or personal computer. In this study, we examined the validity and discrimination ability of the CompBased-CAT. METHODS: Participants were recruited from the Otasha-Kenshin study carried out in 2016. We included 773 community-dwelling older individuals in Japan (332 men, 441 women, aged 65-97 years). CompBased-CAT scores were converted to z-scores, and the correlation with Mini-Mental State Examination scores was examined using Pearson's correlation coefficient. Furthermore, the ability to discern cognitive impairment was examined using the receiver operating characteristic curve. RESULTS: The Pearson's correlation coefficient for the Mini-Mental State Examination scores and each task component of the CompBased-CAT ranged from 0.24 to 0.41 (P < 0.001), and the correlation coefficient of the total z-scores was 0.51 (P < 0.001). The sensitivity, specificity and area under the receiver operating characteristic curve of the discriminating ability of the CompBased-CATool for cognitive impairment were 0.81, 0.77 and 0.85, respectively. CONCLUSIONS: The CompBased-CAT certainly possesses validity, discriminating ability and utility as a new cognitive assessment tool in community-dwelling older individuals. Geriatr Gerontol Int 2020; ••: ••-••.

Limitations of SARC-F in the diagnosis of sarcopenia in community-dwelling older adults
Takeshi Kera; Hisashi Kawai; Hirohiko Hirano; Motonaga Kojima; Yutaka Watanabe; Keiko Motokawa; Yoshinori Fujiwara; Yosuke Osuka; Narumi Kojima; Hunkyung Kim; Kazushige Ihara; Shuichi Obuchi
Archives of Gerontology and Geriatrics, 87, 103959, 103959, Elsevier {BV}, Mar. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: The SARC-F is a recommended screening tool for sarcopenia; however, its sensitivity is reported to be very low. This study aimed to confirm the diagnostic efficacy of the SARC-F and whether it is affected by population characteristics. METHODS: In this study, 2 cohorts of 1060 community-dwelling older adults, who were monitored by the Tokyo Metropolitan Institute of Gerontology, were included. In addition to the overall dataset, receiver operating characteristic curve analysis was performed to obtain the SARC-F results for sarcopenia among the datasets for only those older in age (over 75 years), those with higher frailty points (above the median total score for the Kihon Checklist points), those with lower grip strength (below the median), lower gait speed (below the median), and those with comorbidities (hypertension, cerebral vascular disease, heart disease, and diabetes mellitus). RESULTS: In the overall dataset, sensitivity and specificity were 3.9% and 97.3%, respectively. In analyzing the area under the curve, sensitivity and specificity for older age and low physical function datasets were significant, but had low values. The diabetes dataset had higher values but did not effectively diagnose sarcopenia at a cutoff value of 4. CONCLUSION: The SARC-F had high specificity for the diagnosis of sarcopenia in community-dwelling older adults with low physical function. However, its sensitivity was low. Despite these limitations, it may be used as a screening tool for sarcopenia in selected populations, such as adults in hospitals or nursing homes.

Association of eating alone with oral frailty among community-dwelling older adults in Japan
Yuki Ohara; Keiko Motokawa; Yutaka Watanabe; Maki Shirobe; Hiroki Inagaki; Yoshiko Motohashi; Ayako Edahiro; Hirohiko Hirano; Akihiko Kitamura; Shuichi Awata; Shoji Shinkai
Archives of Gerontology and Geriatrics, 87, 104014, 104014, Elsevier {BV}, Mar. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Because the oral cavity plays an important role as the first digestive organ, thus, decreased oral function such as oral frailty may negatively affect the nutritional status of older adults. However, few studies have examined the relationship between oral frailty and dietary habits. OBJECTIVE: This cross-sectional study aimed to investigate the relationship between oral functions and dietary habits in a general population of older adults. METHODS: Participants were 722 older adults (mean age, 79.1 ± 4.5 [standard deviation] years) who had participated in the Takashimadaira Study conducted in 2018, in Tokyo, Japan. Oral frailty among them was determined by a modified version of a well-known method originally proposed by other researchers. Dietary habits were evaluated based on two aspects: dietary variety and eating behavior (eating alone or together). The independent association between oral frailty and dietary habits was analyzed with an ordinal logistic regression model, controlling for important covariates. RESULTS: Of the participants, 23.5 %, 57.2 % and 19.3 % were determined to have non-oral frailty, pre-oral frailty, and oral frailty, respectively. Eating alone (practiced by 36.0 % of the participants) was significantly associated with oral frailty status (adjusted odds ratio, 1.82 [95 % confidence interval, 1.14-2.90]) even after controlling for potential confounders including age, sex, body mass index, living arrangement, employment, chronic medical conditions, and depressive mood. CONCLUSIONS: We found a significant association between eating alone and oral frailty in a general population of Japanese older adults. Because of the strong association, further investigation of potential mechanisms is warranted.

Association between simple evaluation of eating and swallowing function and mortality among patients with advanced dementia in nursing homes: 1-year prospective cohort study
Daichi Hoshino; Yutaka Watanabe; Ayako Edahiro; Yoshihiro Kugimiya; Kentaro Igarashi; Keiko Motokawa; Yuki Ohara; Hirohiko Hirano; Mie Myers; Shouji Hironaka; Yasubumi Maruoka
Archives of Gerontology and Geriatrics, 87, 103969, 103969, Elsevier {BV}, Mar. 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, BACKGROUND: A simple and predictable method of evaluating eating and swallowing has not been yet established; thus, it is difficult to implement advance care planning according to deterioration in this function. This study aimed to clarify the association between a simple evaluation of eating and swallowing function and 1-year mortality in advanced dementia patients in nursing homes in Japan. METHODS: The study included 325 residents with advanced dementia. In a baseline survey, we examined medical history, physical function, and eating and swallowing function. We recorded mortality for 1 year from baseline. Kaplan-Meier survival analysis and Cox proportional regression were performed to investigate the association between the simple evaluation of eating and swallowing function and mortality. RESULTS: Statistical analysis included data from 312 of the 325 residents who had completed the baseline survey (7 individuals with non-oral ingestion and 6 who were alive but did not reside in the nursing home 1 year later were excluded). The participants' mean age was 85.2 years, and 79.5 % of participants were female. At the 1-year follow-up, 70 patients had died. According to Cox proportional regression analysis, age, male gender, history of cerebrovascular disorder, poor results of palpation of masseter muscle tension, and modified water swallowing test were significantly associated with 1-year mortality. CONCLUSION: The results of palpation of masseter muscle tension and modified water swallowing test were associated with 1-year mortality. These routine observations can predict mortality, and may thus provide evidence of the opportunity to implement advance care planning.

Association of Dietary Variety and Appetite with Sleep Quality in Urban-Dwelling Older Japanese Adults
K. Yamamoto; Keiko Motokawa; T. Yoshizaki; T. Yano; H. Hirano; Y. Ohara; M. Shirobe; H. Inagaki; S. Awata; S. Shinkai; Y. Watanabe
Journal of Nutrition, Health and Aging, 24, 2, 152, 159, 01 Feb. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal

Factors associated with masticatory performance in community-dwelling older adults: A cross-sectional study.
Yoshihiro Kugimiya; Yutaka Watanabe; Kentaro Igarashi; Daichi Hoshino; Keiko Motokawa; Ayako Edahiro; Takayuki Ueda; Tomofumi Takano; Kaoru Sakurai; Yu Taniguchi; Akihiko Kitamura; Ikuo Nasu; Shoji Shinkai; Hirohiko Hirano
Journal of the American Dental Association (1939), 151, 2, 118, 126, Feb. 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, BACKGROUND: Decreased masticatory performance leads to deterioration of overall health among older adults. However, maintaining and improving masticatory performance in ways other than maintenance of natural teeth and appropriate prosthodontic treatment remains unclear. If the factors related to the mixing and shearing abilities for masticatory performance are clarified, it may be possible to maintain and improve the masticatory performance of older adults. We aimed to clarify the association among mixing ability, shearing ability, and masticatory performance-related factors. METHODS: Of the 707 community-dwelling older adults in Kusatsu Town, Japan, 344 who had been treated for any dental defects were enrolled in this study. Masticatory performance was evaluated on the basis of mixing ability and shearing ability. The number of natural teeth and artificial teeth, occlusal force, tongue pressure, and oral diadochokinesis /ta/ were measured as masticatory performance-related factors. Their relationship with mixing ability, shearing ability, and masticatory performance-related factors was examined by means of Spearman rank correlation coefficient and path analysis. RESULTS: Among masticatory performance-related factors, the number of natural teeth, occlusal force, and tongue pressure were directly associated with both mixing ability and shearing ability. Moreover, mixing ability was also directly associated with shearing ability. CONCLUSIONS: Tongue pressure, which can be improved by means of training, is a masticatory performance-related factor associated with both mixing and shearing abilities. PRACTICAL IMPLICATIONS: Training for tongue pressure after proper prosthetic treatment may provide an effective means of maintaining and improving masticatory performance in older adults.

The Mini Nutritional Assessment-Short Form as a predictor of nursing home mortality in Japan: A 30-month longitudinal study
Keiko Motokawa; Jun Yasuda; Yurie Mikami; Ayako Edahiro; Shiho Morishita; Maki Shirobe; Yuki Ohara; Kanji Nohara; Hirohiko Hirano; Yutaka Watanabe
Archives of Gerontology and Geriatrics, 86, 103954, 103954, Elsevier {BV}, Jan. 2020, [Peer-reviewed], [Corresponding author]
Scientific journal

Association between Oral Frailty and Nutritional Status among Community-Dwelling Older Adults: the Takashimadaira Study.
M Iwasaki; K Motokawa; Y Watanabe; M Shirobe; H Inagaki; A Edahiro; Y Ohara; H Hirano; S Shinkai; S Awata
The journal of nutrition, health & aging, 24, 9, 1003, 1010, 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Recently, the concept of oral frailty, defined as accumulated deficits in oral health, has been introduced in Japan. However, data about its association with nutritional status are limited. Thus, this cross-sectional study aimed to investigate the association between oral frailty and malnutrition among community-dwelling older adults. DESIGN: Cross-sectional study. SETTING: Community. PARTICIPANTS: One thousand and fifty-four individuals (428 men and 626 women, mean age: 77.0 years) from the Takashimadaira Study. MEASUREMENTS: Based on a multifaceted oral health assessment, oral frailty was defined as greater than or equal to three of the following components: (1) low number of remaining teeth, (2) decreased masticatory performance, (3) reduced articulatory oral motor skill, (4) low tongue pressure, and difficulties in (5) eating and (6) swallowing. The nutritional status was evaluated using the Mini Nutritional Assessment®-Short Form (MNA®-SF) and serum albumin. An ordinal logistic regression model was used to evaluate the association between oral frailty and nutritional status. RESULTS: Oral frailty was observed in 217 (20.4%) participants. After adjusting for potential confounders, the participants with oral frailty had higher odds of more severe malnutrition evaluated using MNA®-SF (adjusted odds ratio: 2.17; 95% confidence interval: 1.58-2.98) and serum albumin level (adjusted odds ratio: 1.59; 95% confidence interval: 1.10-2.31). CONCLUSION: Oral frailty was associated with nutritional status among Japanese older adults. Maintaining comprehensive oral health and function may be effective for malnutrition prevention in community-dwelling older adults. However, further studies must be conducted to validate the generalizability of the results of the current study.

Exercise Types and the Risk of Developing Cognitive Decline in Older Women: A Prospective Study.
Yosuke Osuka; Narumi Kojima; Hiroyuki Sasai; Yuki Ohara; Yutaka Watanabe; Hirohiko Hirano; Hunkyung Kim
Journal of Alzheimer's disease : JAD, 77, 4, 1733, 1742, 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Participation in exercise may be useful for dementia prevention; however, the specific exercise types which may best to reduce the risk of developing cognitive decline have remained unidentified in the literature. OBJECTIVE: To examine the relationships of specific exercise types with the risk of developing cognitive decline in older women. METHODS: This 1- to 2-year population-based cohort study included 687 community-dwelling older Japanese women without disability, neurological disease, dementia, or cognitive impairment assessed as <24 points on the Mini-Mental State Examination (MMSE) at the baseline survey. Developing cognitive decline was defined as a decrease of ≥3 points in the participant's MMSE score during the follow-up. We classified individuals into participation (≥3 months) and non-participation (<3 months) groups for 17 different exercise types. Log-binominal regression analyses were applied to compare risk ratios and confidence intervals of developing cognitive decline between the two groups. RESULTS: Thirty-nine participants (5.7%) developed cognitive decline during the follow-up period. After adjusting for confounders (age, MMSE score, depressive symptoms, body mass index, heart disease, hypertension, diabetes, smoking, low educational level, and the follow-up period in the baseline survey), those who participated in calisthenics demonstrated a significantly lower risk of developing cognitive decline than those who did not participate in calisthenics. No significant relationships between other exercise types and the risk of developing cognitive decline were found. CONCLUSION: Participation in calisthenics significantly reduced the risk of cognitive decline in community-dwelling older Japanese women, indicating that calisthenics may be a useful type of exercise for promoting dementia prevention.

Factors associated with follow-up difficulty in longitudinal studies involving community-dwelling older adults.
Hisashi Kawai; Manami Ejiri; Harukazu Tsuruta; Yukie Masui; Yutaka Watanabe; Hirohiko Hirano; Yoshinori Fujiwara; Kazushige Ihara; Masashi Tanaka; Shuichi Obuchi
PloS one, 15, 8, e0237166, 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, This study aims to clarify the factors associated with the gradual withdrawal from society in older adults. We defined the stages of follow-up difficulty based on four follow-up surveys on non-respondents of longitudinal mail surveys in community-dwelling older adults to examine the main factors associated with the stages of follow-up difficulty. We conducted a follow-up mail survey (FL1) with respondents of a baseline survey, and three more follow-up surveys with the non-respondents of each previous survey: simplified mail (FL2), postcard (FL3), and home visit surveys (FL4). The respondents of each follow-up survey were defined as a stage of follow-up difficulty; their characteristics concerning social participation and interaction at baseline in each stage were analyzed. The number of respondents in the FL1, FL2, FL3, and FL4 stages and non-respondents (NR) were as follows: 2,361; 462; 234; 84; and 101, respectively. Participation in hobby groups in FL2 and FL3, sports groups in FL4, and neighborhood association and social isolation in NR were significantly associated with the stage of follow-up difficulty. Based on these results, we conclude that the following factors are associated with each stage of follow-up difficulty: 1) a decline in instrumental activities of daily living in the FL2 and FL3 stages, 2) dislike for participating in physical activity such as sports in the FL4 stage, and 3) social isolation, not even belonging to a neighborhood association due to low social interaction in the NR group.

Posterior vitreous detachment and macular microvasculature in the elderly.
Taku Toyama; Hisashi Kawai; Tomoyasu Shiraya; Fumiyuki Araki; Koichiro Sugimoto; Yohei Hashimoto; Satoshi Kato; Jiro Numaga; Yutaka Watanabe; Hirohiko Hirano; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Shuichi Obuchi; Takashi Ueta
PloS one, 15, 4, e0231351, 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To investigate the association between different stages of posterior vitreous detachment (PVD) and macular microvasculature in the elderly. METHODS: Swept-source optical coherence tomography (OCT), OCT angiography, and color fundus images of 490 eyes without retinal pathologies of 322 participants aged ≥65 years were evaluated. PVD was classified using enhanced vitreous visualization mode as no apparent PVD (stage 0/1), vitreous adhesions at the fovea and optic disc (stage 2), adhesion at the optic disc (stage 3), or complete PVD (stage 4). Microvascular parameters, including foveal avascular zone (FAZ) and vessel density (VD), were analyzed for their associations with complete PVD. Additionally, the association between PVD and central retinal thickness (CRT) was also addressed. RESULTS: Overall, 80, 31, 31, and 349 eyes were categorized into stages 0/1, 2, 3, and 4, respectively. Using multivariate mixed-effects model, the mean superficial FAZ area was smaller in stage 4 compared with stages 0-3 (0.29 vs. 0.32 mm2; P = 0.014), and the mean superficial VD was lower in stage 4 compared with stages 0-3 (34.96% vs. 35.24%; P = 0.0089). However, PVD was not significantly associated with deep macular microvascular parameters or CRT. CONCLUSIONS: Complete PVD was associated with smaller FAZ area and lower VD in superficial macular microvasculature, while it was not associated with central retinal thickness.

An Epidemiological Study of the Risk Factors of Bicycle-Related Falls Among Japanese Older Adults
Ryota Sakurai; Hisashi Kawai; Hiroyuki Suzuki; Susumu Ogawa; Hunkyung Kim; Yutaka Watanabe; Hirohiko Hirano; Kazushige Ihara; Shuichi Obuchi; Yoshinori Fujiwara
Journal of Epidemiology, 29, 12, 487, 490, Japan Epidemiological Association, 05 Dec. 2019, [Peer-reviewed]
Scientific journal

サルコペニアがピークフローに与える影響
解良武士; 河合恒; 平野浩彦; 渡邊裕; 小島基永; 藤原佳典; 井原一成; 大渕修一
日本呼吸ケア・リハビリテーション学会誌, 28, 2, 298, 302, Dec. 2019, [Peer-reviewed]
Japanese, Scientific journal

Relation between knee extension torque and occlusal force in community-dwelling elderly adults.
Kentaro Igarashi; Yutaka Watanabe; Hisashi Kawai; Keiko Motokawa; Kento Umeki; Masayasu Ito; Takeshi Kera; Motonaga Kojima; Kazushige Ihara; Yoshinori Fujiwara; Hunkyug Kim; Shuichi Obuchi; Hirohiko Hirano; Yasuhiko Kawai
Journal of oral science, 61, 4, 508, 511, 27 Nov. 2019, [Peer-reviewed], [Corresponding author], [Domestic magazines]
English, Scientific journal, The relation between occlusal force and general motor ability induced by lower-limb musculature is unclear. To identify indicators of oral and lower-limb muscle weakness, this study examined the relation between masticatory muscle strength and lower limb muscle force in 742 community-dwelling elderly adults (315 men and 427 women, mean age 73.3 ± 5.5 years) living in Itabashi ward, Tokyo. Multiple regression analysis of the relation between occlusal force and knee extension torque, in relation to age and sex, showed a significant correlation between the two variables (r = 0.348, P < 0.001), which indicates that occlusal force is a determinant of knee extension torque. Occlusal force remained significantly correlated with knee extension torque after adjustment for factors known to be related to the latter. In conclusion, chewing function and lower-limb motor function were significantly correlated and thus might be indicators of muscle weakness in elderly adults.

SARC-F: A validation study with community-dwelling older Japanese adults.
Takeshi Kera; Hisashi Kawai; Hirohiko Hirano; Motonaga Kojima; Yutaka Watanabe; Keiko Motokawa; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Shuichi Obuchi
Geriatrics & gerontology international, 19, 11, 1172, 1178, Wiley, Nov. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: The SARC-F is a useful clinical index for sarcopenia screening; however, this measure has low sensitivity. Furthermore, this tool has never been validated on community-dwelling older Japanese adults. The goal of the present study was to validate a Japanese version of the SARC-F and confirm its suitability for Japanese samples. METHODS: Participants were 734 community-dwelling older adults in the Itabashi Ward, Japan. Bioimpedance measures, walking speed, grip strength and instrumental activities of daily living (IADL) were measured. Sarcopenia was defined using the European Working Group on Sarcopenia in Older People, the Asian Working Group for Sarcopenia criteria and Japanese-adjusted Asian Working Group for Sarcopenia. SARC-F receiver operating characteristic curves for each sarcopenia measure were used to evaluate diagnostic accuracy. Physical functioning, IADL and sarcopenia screening tools were compared with the SARC-F. RESULTS: A total of nine men (3.1%) and 15 women (3.4%) were classified into a SARC-F sarcopenia group. The sarcopenia group had lower physical functioning and Mini Sarcopenia Risk Assessment scores and higher frailty status than the control group. The Cronbach's alpha for the SARC-F was 0.610, suggesting insufficient internal consistency. SARC-F scores were related to physical functioning, IADL, and Mini Sarcopenia Risk Assessment scores. Receiver operating characteristic analyses of the SARC-F based on each criterion showed low sensitivity, but high specificity. CONCLUSIONS: The Japanese version of the SARC-F appears to be a useful index for reflecting physical functioning and IADL. However, it is necessary to further determine whether this tool is useful for detecting sarcopenia among community-dwelling older adults. Geriatr Gerontol Int 2019; 19: 1172-1178.

Poor Social Network, Not Living Alone, Is Associated With Incidence of Adverse Health Outcomes in Older Adults
Ryota Sakurai; Hisashi Kawai; Hiroyuki Suzuki; Hunkyung Kim; Yutaka Watanabe; Hirohiko Hirano; Kazushige Ihara; Shuichi Obuchi; Yoshinori Fujiwara
Journal of the American Medical Directors Association, 20, 11, 1438, 1443, Elsevier {BV}, Nov. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: Although it has been suggested that living alone is a "social risk factor" for adverse health outcomes, poor social network may confound the association. This study aimed to examine whether the interactive effects of living alone and poor social network contribute to adverse health outcomes. DESIGN: A 4-year prospective observational study. SETTING AND PARTICIPANTS: Four hundred community-dwelling older adults living in Itabashi ward, an urban community in Tokyo. They participated in a health checkup (held in 2015 and 2017) and completed all the assessments. METHODS: Participants were classified into 4 groups according to their living arrangements (living alone or not living alone) and social network size, which was assessed using an abbreviated version of the Lubben Social Network Scale-6. Poor social network was defined as the lowest quartile (4th quartile) of the Lubben Social Network Scale-6 score. Adverse health outcomes including disabilities, depressive symptoms, and physical and cognitive functions were measured. RESULTS: Multiple and logistic regression models, adjusted for covariates such as financial status and educational level, showed that living alone and having a poor social network at baseline were significantly associated with increased depression symptoms, reduced grip strength, and disabilities of intellectual activity and social role at follow-up. Furthermore, older adults who did not live alone but had poor social networks showed significantly higher odds of subsequent homebound status and disability in activities of daily living. CONCLUSIONS AND IMPLICATIONS: We found that living alone among older adults is not always a social risk factor for health, and adverse health outcomes among older adults living alone may be confounded by poor social network. Our results also suggest that the effect of poor social network on health status may exceed the effects of living alone. Health professionals must, thus, pay attention to poor social network among older adults.

Association between decrease in frequency of going out and oral function in older adults living in major urban areas
Yurie Mikami; Yutaka Watanabe; Keiko Motokawa; Maki Shirobe; Yoshiko Motohashi; Ayako Edahiro; Junko Nakajima; Yosuke Osuka; Hiroki Inagaki; Yoshinori Fujiwara; Shoji Shinkai; Shuichi Awata
Geriatrics & Gerontology International, 19, 8, 792, 797, Wiley, 02 Aug. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: To examine the association between a decrease in the frequency of going out and oral function in independent older adults living in the urban area of Tokyo. METHODS: The participants analyzed were 785 older adults from the "Takashimadaira Study" (344 men and 441 women, age 77.0 ± 4.6 years). This study investigated the following items: decrease in frequency of going out; basic characteristics (sex, age); physical factors, such as oral function (difficulty chewing, difficulty swallowing, dry mouth); body pain; the Japan Science and Technology Agency Index of Competence; physical activities; psychological factors, such as the Geriatric Depression Scale-15 score; and social and environmental factors, such as the presence or absence of participation in organization activities. RESULTS: To investigate the factors associated with a decrease in frequency of going out, logistic regression analysis showed an association with age (OR 1.08, 95% CI 1.03-1.13), difficulty chewing (OR 2.41, 95% CI 1.52-3.83), dry mouth (OR 1.68, 95% CI 1.07-2.64), body pain (OR 1.78, 95% CI 1.14-2.78), Japan Science and Technology Agency Index of Competence scores (OR 0.91, 95% CI 0.84-0.99), physical activities (OR 0.99, 95% CI 0.98-1.00), Geriatric Depression Scale-15 scores (OR 1.13, 95% CI 1.05-1.21) and organization activities (OR 1.94, 95% CI 1.22-3.07). Covariance structural analyses showed that both "difficulty chewing" and "dry mouth" significantly affected "decrease in frequency of going out." In addition, decrease in frequency of going out was significantly affected by " Geriatric Depression Scale-15 scores" through oral function. CONCLUSIONS: The relationship between oral function and decrease in frequency of going out was clarified, after the multifaceted factors were adjusted. Geriatr Gerontol Int 2019; 19: 792-797.

Definition of Respiratory Sarcopenia With Peak Expiratory Flow Rate
Takeshi Kera; Hisashi Kawai; Hirohiko Hirano; Motonaga Kojima; Yutaka Watanabe; Keiko Motokawa; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Shuichi Obuchi
Journal of the American Medical Directors Association, 20, 8, 1021, 1025, Elsevier {BV}, Aug. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Respiratory muscle strength decreases with advancing age, and respiratory muscle dysfunction may indicate respiratory sarcopenia. However, there is no consensus regarding the definition of respiratory sarcopenia. We aimed to create a definition of respiratory sarcopenia based on the peak expiratory flow rate (PEFR). DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: Community-based study including 681 community-dwelling older people. METHODS: Body composition, spirometry, grip strength, and walking speed were measured. Participants reported comorbidities and long-term insurance certification. Conventional sarcopenia was defined using skeletal muscle mass, grip strength, and walking speed adjusted for the Japanese population. Receiver operating characteristic (ROC) curve analysis of the cut-off values of PEFR for conventional sarcopenia and long-term care insurance certification were performed for both sexes without airway obstruction. In the ROC curve analysis, potential cut-off values were lowest quartile, lowest quintiles, and the standard deviation of PEFR. Multiple logistic regression analysis was performed with respiratory sarcopenia as a dependent variable defined by each cut-off value and other variants as independent variables. RESULTS: The ROC curve analysis for conventional sarcopenia and long-term care insurance certification showed significance for both sexes, and we determined cut-off values from those results. The multiple logistic regression model using PEFR values 1 standard deviation below the mean had the highest accuracy; thus, we accepted these cut-off values (4.40 L/s for men, 3.21 L/s for women) for the definition of respiratory sarcopenia. CONCLUSIONS/IMPLICATIONS: The definition of respiratory sarcopenia based on PEFR was useful and correlated with conventional sarcopenia and long-term care insurance certification among community-dwelling older people. In this study, respiratory sarcopenia was determined by PEFR alone. Other parameters may need to be considered.

Cognitive frailty in community‐dwelling older Japanese people: Prevalence and its association with falls
Hunkyung Kim; Shuichi Awata; Yutaka Watanabe; Narumi Kojima; Yosuke Osuka; Keiko Motokawa; Naoko Sakuma; Hiroki Inagaki; Ayako Edahiro; Erika Hosoi; Chang‐Won Won; Shoji Shinkai
Geriatrics & Gerontology International, 19, 7, 647, 653, 13 May 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, AIM: To investigate the prevalence and associated factors of cognitive frailty and cognitive frailty-related falls in community-dwelling older people. METHODS: A total of 25 out of 1192 community-dwelling older people aged >70 years with cognitive frailty participated in the present cross-sectional study. Cognitive function was assessed using the Mini-Mental State Examination. Physical function measures included calf circumference, Timed Up and Go (TUG) and usual walking speed. Interviews were carried out to assess Council on Nutrition Appetite Questionnaire (CNAQ); chronic diseases including hypertension, diabetes and falls; as well as physical frailty, defined as having three of five criteria: muscle weakness, slowness, exhaustion, low activity and weight loss. RESULTS: The prevalence of cognitive frailty was 2.1%. Participants with cognitive frailty had significantly reduced Mini-Mental State Examination and calf circumference; and higher instrumental activities of daily living disability and falls. Old age (OR 1.151, 95% CI 1.053-1.257), fall history (OR 3.577, 95% CI 1.381-9.263), having four or more chronic diseases (OR 7.419, 95% CI 2.117-26.005) and slower TUG (OR 1.234, 95% CI 1.041-1.462) were significantly associated with cognitive frailty, whereas greater calf circumference (OR 0.748, 95% CI 0.625-0.895) and CNAQ (OR 0.736, 95% CI 0.628-0.8631) had protective effects. Old age (OR 1.132, 95% CI 1.002-1.280), hospitalization (OR 10.090, 95% CI 2.554-39.854), having four or more chronic diseases (OR 5.120, 95% CI 1.113-23.557) and slower TUG (OR 1.394, 95% CI 1.167-1.665) were significantly associated with cognitive frailty-related falls, whereas CNAQ (OR 0.704, 0.571-0.868) had protective effects. CONCLUSIONS: Age, chronic disease, TUG and CNAQ were significantly associated with cognitive frailty and cognitive frailty-related falls. The TUG and CNAQ have the greatest potential for improvement by intervention or lifestyle change. Further research is necessary to determine the efficacy of positive changes in these factors for symptomatic improvements. Geriatr Gerontol Int 2019; 19: 647-653.

Qualitative analysis of the vocabulary used in work logs of a preventive programme for elderly oral function and nutrition
Kayoko Ito; Ayako Edahiro; Yoshihiko Watanabe; Yuki Ohara; Yoshiko Motohashi; Shiho Morishita; Keiko Motokawa; Yutaka Watanabe; Hirohiko Hirano; Makoto Inoue
Journal of Oral Rehabilitation, 46, 8, 723, 729, Wiley, 08 May 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: In Japan, day care services for elders include programmes aimed at improving nutrition and oral and motor functions. Few studies have qualitatively assessed these interventions. OBJECTIVE: To qualitatively search for the characteristic words used in the work logs of a preventive programme on oral function and nutrition for elders by intervention period and intervention type． METHODS: We included 83 participants (81.3 ± 8.2 years) from four day care services in Japan and divided them into the following groups randomly: those who received oral function intervention only, nutritional intervention only and those who received combined oral function plus nutritional intervention. The interventions were conducted twice per month for 24 months. Data from handwritten work logs were entered into a computer as text files. Monitoring of frequently appearing words, co-occurrence analysis and cross-tabulation by intervention period and intervention types was conducted using text mining analysis. RESULTS: Correspondence analysis revealed that the words used during 1-6 months and 7-12 months were similar in participants' subjective content, and those used in objective content in 13-18 months and 19-24 months were similar. These results indicate that subjective improvements increased after 13 months, and it was maintained within 24 months. The combined intervention type is ideal for oral and nutrition problems. CONCLUSION: Because this text mining approach revealed the changes in the words used and could be used to monitor any subjective improvement, this approach may help evaluate the effects of preventive care.

Validity of a visual scoring method using gummy jelly for evaluating chewing efficiency in a large‐scale epidemiological survey
Kentaro Igarashi; Yutaka Watanabe; Yoshihiro Kugimiya; Maki Shirobe; Ayako Edahiro; Koh Kaneda; Yoko Hasegawa; Masayasu Ito; Hirohiko Hirano; Kaoru Sakurai; Takahiro Ono; Hiroki Inagaki; Shuichi Awata; Yasuhiko Kawai
Journal of Oral Rehabilitation, 46, 5, 409, 416, Wiley, May 2019, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, BACKGROUND: Several methods exist for objectively evaluating chewing efficiency by using gummy jelly. However, the validity of the subjective visual evaluation of chewing efficiency has not been assessed. OBJECTIVE: To verify with an epidemiological study, the validity of a visual scoring method using gummy jelly by testing the relationship between masticatory performance (MP) using a fully automatic measuring system and visual score (VS) using a visual scoring method. METHODS: Community-dwelling elderly individuals (n = 1234) ≥70 years old participated. One evaluator measured VS consecutively after participants chewed the gummy jelly (ie, actual-VS). The chewed jelly was photographed. Two evaluators used the photograph to measure the gummy jelly (ie, photo-VS). To test the validity of both methods, the correlation between actual-VS and MP and between photo-VS and MP were analysed. Inter-rater reliability between the evaluators of photo-VS was analysed. RESULTS: Significant correlations existed between actual-VS and MP and between photo-VS and MP (r = 0.86-0.87; P < 0.001). The intra-class correlation coefficient of the inter-rater reliability for photo-VS was very high (0.93; P < 0.001; 95% confidence interval: 0.877-0.953); however, the distribution of photo-VS deviated slightly from the actual-VS. A large coefficient of variation in the MP for low VSs suggested the influence of incomplete comminution, which was not reflected by the VS, and the accidental swallowing of small pieces during chewing. CONCLUSION: The VS deviated slightly from the MP calculated using a fully automated method; however, the VS can be utilised for epidemiological surveys with numerous participants.

Relationship between mild cognitive decline and oral motor functions in metropolitan community-dwelling older Japanese: The Takashimadaira study
Yoshihiro Kugimiya; Takayuki Ueda; Yutaka Watanabe; Tomofumi Takano; Ayako Edahiro; Shuichi Awata; Kaoru Sakurai
Archives of Gerontology and Geriatrics, 81, 53, 58, Elsevier BV, Mar. 2019, [Peer-reviewed]
Scientific journal

Self-Feeding Ability as a Predictor of Mortality Japanese Nursing Home Residents: A Two-Year Longitudinal Study
yutaka watanabe
The Journal of Nutrition, Health & Aging, 23, 2, 157, 164, 2019, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal

Overlap Between Apolipoprotein Eε4 Allele and Slowing Gait Results in Cognitive Impairment.
Ryota Sakurai; Yutaka Watanabe; Yosuke Osuka; Yu Taniguchi; Hisashi Kawai; Hunkyung Kim; Akihiko Kitamura; Hiroki Inagaki; Manuel Montero-Odasso; Shuichi Awata; Shoji Shinkai
Frontiers in aging neuroscience, 11, 247, 247, 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: Although apolipoprotein E polymorphism ε4 allele (ApoE4) and slow gait are well-known risk factors for cognitive impairment, examination of their combined effect on cognitive function is lacking. Our objective was to elucidate whether a combination of ApoE4 phenotyping and slow gait resulted in greater cognitive impairment. Methods: Overall, 1,085 community-dwelling older adults, either ApoE4 carriers (n = 167, 15.4%) or non-ApoE4 carriers, were included from the "Takashimadaira study." Gait speed was assessed with an electronic walkway and slow gait was defined as <1 m/s. Cognitive performance was also assessed using the Mini-Mental State Exam (MMSE) and the Trail Making Test (TMT)-A and -B. A two-way analysis of covariance (ANCOVA; ApoE and gait velocity factors) adjusted for covariates was performed for each analysis. Results: Gait and cognitive performances were similar for ApoE4 and non-ApoE4 carriers. A two-way ANCOVA of the MMSE showed a significant interaction between the two factors. ApoE4 carriers with slow gait had lower MMSE scores than ApoE4 carriers without slow gait and non-ApoE4 carriers with slow gait. Also, a significant main effect of gait velocity on TMT-A was observed, indicating that slow gait is associated with lower scores irrespective of the presence of ApoE4. There was no main effect or interaction observed on the TMT-B. Conclusions: Our results suggest that the concurrent presence of at least one copy of ApoE4 and slow gait can define a subgroup with the lowest cognition. Elucidating the mechanisms underlying these associations may point out modifiable factors in populations at risk of dementia.

Social participation reduces isolation among Japanese older people in urban area: A 3-year longitudinal study.
Manami Ejiri; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Yutaka Watanabe; Hirohiko Hirano; Hun Kyung Kim; Kaori Ishii; Koichiro Oka; Shuichi Obuchi
PloS one, 14, 9, e0222887, 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Social isolation is a particular problem among older people and social participation may reduce future isolation. However, it is unclear which types of activities and which level of participation are effective. This study examines the relationship between social participation and isolation among Japanese older people by employing a 3-year longitudinal study. METHODS: A mail survey was sent to 3,518 community-dwelling older people in an urban area in 2014 (baseline: BL). We then conducted follow-up mail survey on respondents who were non-isolated at BL in 2017 (follow-up: FL), with isolation being defined as being in contact with others less than once a week. An analysis was carried out on 1,070 subjects (398 men and 672 women). Social participation is defined by participation in group activities (community, senior club, hobbies, sports, volunteering, politics, industry, and religion). A logistic regression analysis was conducted to determine the association between the types of social participation and the number of organization types at BL, and isolation at FL. RESULTS: At FL, 75 men (18.8%) and 59 women (8.8%) were considered to be isolated. Among the men, participation in a hobby group and sports group both significantly reduced the degree of isolation. Moreover, participation in two organizations and three or more organizations significantly lowered the risk of isolation when compared to non-participants. Among women, there were no significant associations among particular types of social activities and isolation. On the other hand, participation in one organization and three or more organizations significantly reduced their isolation when compared to non-participants. There was a significant linear trend between the number of types of organizations and isolation, regardless of gender. CONCLUSIONS: Participation in social activities reduces future isolation in older people. Encouraging participation in social activities could help reduce negative health outcomes associated with social isolation later in life.

Reference values of gait parameters measured with a plantar pressure platform in community-dwelling older Japanese adults.
Hisashi Kawai; Yu Taniguchi; Satoshi Seino; Ryota Sakurai; Yosuke Osuka; Shuichi Obuchi; Yutaka Watanabe; Hunkyung Kim; Hiroki Inagaki; Akihiko Kitamura; Shuichi Awata; Shoji Shinkai
Clinical interventions in aging, 14, 1265, 1276, 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: Gait measures such as gait speed, stride length, step width, and stance duration change with advanced age and are associated with adverse health outcomes among older adults. The stride-to-stride variabilities of gait measures are also related to falls and cognitive decline in older adults; however, reference values of these gait parameters in older Japanese adults do not exist. This study aimed to determine the reference values of gait parameters as measured by a plantar pressure platform in community-dwelling older Japanese adults. Methods: Community-dwelling adults (N=1,212) who were independent in basic activities of daily living and aged 70-96 years (491 men, 721 women) completed the gait performance measurement in a geriatric health assessment. We assessed 10 gait performance measures with a plantar pressure platform system (P-WALK, BTS Bioengineering) and calculated means and coefficient of variations (CVs) of the gait measures as well as quintiles for those gait parameters per age group among men and women. Results: Mean (SDs) of gait speed, stride length, step width, and stance durations were 1.26 (0.24) meters per second (m/s), 121.9 (19.8) cm, 24.0 (3.2) cm, and 552.4 (60.4) milliseconds (ms), respectively, in men, and 1.27 (0.21) m/s, 115.7 (16.3) cm, 17.9 (2.8) cm, and 517.6 (59.8) ms, respectively, in women. Mean of CVs (SD) of stride length, step width, and single-stance duration were 2.76 (1.35), 12.06 (3.98), and 5.74 (2.66), respectively, in men and 2.69 (1.24), 15.65 (4.53), and 5.77 (2.40), respectively, in women. Gait parameters (except CVs of step width) declined significantly with age regardless of gender (P< 0.01 for trends). Conclusion: This study determined age group dependent gait parameter reference values, presented as means with quintile ranges, in community-dwelling older Japanese adults. These reference values may be useful metrics for gait assessment in the elderly.

Relationship between mortality and Council of Nutrition Appetite Questionnaire scores in Japanese nursing home residents
Yurie Mikami; Yutaka Watanabe; Ayako Edahiro; Keiko Motokawa; Maki Shirobe; Jun Yasuda; Masaharu Murakami; Kohji Murakami; Yu Taniguchi; Junichi Furuya; Hirohiko Hirano
Nutrition, 57, 40, 45, Elsevier {BV}, Jan. 2019, [Peer-reviewed], [Corresponding author]
Scientific journal

Characteristics for gait parameters of community-dwelling elderly Japanese with lower cognitive function.
Yu Taniguchi; Yutaka Watanabe; Yosuke Osuka; Akihiko Kitamura; Satoshi Seino; Hunkyung Kim; Hisashi Kawai; Ryota Sakurai; Hiroki Inagaki; Shuichi Awata; Shoji Shinkai
PloS one, 14, 3, e0212646, 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Recent studies reported that several gait parameters were associated with lower cognitive function or cognitive decline, however, known gait parameters were limited and no study has used large-scale data. We identified the characteristics for gait parameters of community-dwelling elderly Japanese with lower cognitive function. METHODS: 1,240 community-dwelling adults (mean [SD] age, 77.2 [4.8] years; women, 59.4%) aged 70 or older participated in geriatric health assessments in 2016. We measured comprehensive gait parameters using resistive pressure platform. Cognition was assessed by Mini-Mental State Examination (MMSE). RESULTS: There are possible correlations between gait measures (gait speed, stride length, step length, step width, average foot pressure, double support duration, and single support duration) and CVs (CV of stride length, step length, average foot pressure, and single support duration) with MMSE score, respectively. After adjustment for important confounders, multiple regression models showed that gait speed (β = .080, p = 0.006), stride length (β = .123, p<0.001), step length (β = .123, p<0.001), average foot pressure (β = .060, p = 0.040), double support duration (β = -.082, p = 0.004), single support duration (β = .086, p = 0.003), CV of stride length (β = -.091, p<0.001), CV of step length (β = -.090, p<0.001), and CV of single support duration (β = -.058, p = 0.037) had significant association with MMSE score, respectively. CONCLUSIONS: Our findings suggest that person with lower cognitive function tend to have unsteady gait such as erratic length and time of one step, in addition to decreasing the vertical displacement of the center of gravity and slower speed.

Association between Adherence to the Japanese Food Guide Spinning Top and Sleep Quality in College Students.
Kaori Yamamoto; Masako Ota; Ayako Minematsu; Keiko Motokawa; Yuri Yokoyama; Tomohiro Yano; Yutaka Watanabe; Takahiro Yoshizaki
Nutrients, 10, 12, 16 Dec. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, This study aimed to elucidate the association between adherence to the Japanese Food Guide Spinning Top (Food Guide score) and sleep quality in Japanese college students. We conducted a cross-sectional study of 175 Japanese college students aged 19⁻22 years in the eastern part of Gunma Prefecture to examine the association between the Food Guide score and sleep quality. A self-administered diet history questionnaire and the Pittsburgh Sleep Quality Index were used to assess habitual dietary intake and sleep quality, respectively. In the fully adjusted model, the odds ratios for poor sleep quality in the middle and highest tertile categories of the Food Guide score were 0.50 (95% confidence interval, 0.18⁻1.37) and 0.30 (95% confidence interval, 0.11⁻0.84), respectively, compared with those in the lowest tertile category (p for trend = 0.033). A well-balanced diet may be associated with good sleep quality in Japanese college students.

Oral hypofunction in the older population: Position paper of the Japanese Society of Gerodontology in 2016.
Shunsuke Minakuchi; Kazuhiro Tsuga; Kazunori Ikebe; Takayuki Ueda; Fumiyo Tamura; Kan Nagao; Junichi Furuya; Koichiro Matsuo; Ken Yamamoto; Manabu Kanazawa; Yutaka Watanabe; Hirohiko Hirano; Takeshi Kikutani; Kaoru Sakurai
Gerodontology, 35, 4, 317, 324, Dec. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: There is growing international interest in identifying the effects of ageing on oral health and on appropriate strategies for managing oral disorders. The Japanese Society of Gerodontology (JSG), as the official representative of researchers and clinicians interested in geriatric dentistry in Japan, makes several recommendations on the concept of "oral hypofunction." AIMS: This study proposes diagnostic criteria and management strategies to reduce the risk of oral hypofunction among older people. CONCEPTUAL FRAMEWORK: We define oral hypofunction as a presentation of 7 oral signs or symptoms: oral uncleanness; oral dryness; decline in occlusal force; decline in motor function of tongue and lips; decline in tongue pressure; decline in chewing function; and decline in swallowing function. The criteria of each symptom were determined based on the data of previous studies, and oral hypofunction was diagnosed if the criteria for 3 or more signs or symptoms were met. CONCLUSIONS: We recommend that more evidence should be gathered from clinical studies and trials to clarify our diagnostic criteria and management strategies.

Oral Frailty as a Risk Factor for Physical Frailty and Mortality in Community-Dwelling Elderly.
Tanaka T; Takahashi K; Hirano H; Kikutani T; Watanabe Y; Ohara Y; Furuya H; Tetsuo T; Akishita M; Iijima K
The journals of gerontology. Series A, Biological sciences and medical sciences, 73, 12, 1661, 1667, Nov. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: Oral health is important for maintaining general health among the elderly. However, a longitudinal association between poor oral health and general health has not been reported. We investigated whether poor oral status can predict physical weakening (physical frailty, sarcopenia, and subsequent disability) and identified the longitudinal impact of the accumulated poor oral health (i.e. oral frailty) on adverse health outcomes, including mortality. Methods: A total of 2,011 elderly individuals (aged ≥ 65 years) participated in the baseline survey of the Kashiwa study in 2012. At baseline, 16 oral status measures and covariates such as demographic characteristics were assessed. As outcomes, physical frailty and sarcopenia were assessed at baseline and at follow-up in 2013 and 2014. Physical independence and survival were assessed from 2012 to 2016 at the time of long-term care certification and time of death. Results: Poor oral status as determined by the number of natural teeth, chewing ability, articulatory oral motor skill, tongue pressure, and subjective difficulties in eating and swallowing significantly predicted future physical weakening (new onsets of physical frailty, sarcopenia, and disability). Oral frailty was defined as co-existing poor status in ≥3 of the six measures. Sixteen per cent of participants had oral frailty at baseline, which was significantly associated with 2.4-, 2.2-, 2.3-, and 2.2-fold increased risk of physical frailty, sarcopenia, disability, and mortality, respectively. Conclusion: Accumulated poor oral status strongly predicted the onset of adverse health outcomes, including mortality among the community-dwelling elderly. Prevention of oral frailty at an earlier stage is essential for healthy aging.

A 2-year longitudinal study of the relationship between masticatory function and progression to frailty or pre-frailty among community-dwelling Japanese aged 65 and older
Yasuhiro Horibe; Takayuki Ueda; Yutaka Watanabe; Keiko Motokawa; Ayako Edahiro; Hirohiko Hirano; Maki Shirobe; Koichiro Ogami; Hisashi Kawai; Shuichi Obuchi; Hunkyung Kim; Kaoru Sakurai
Journal of Oral Rehabilitation, 45, 11, 864, 870, Wiley, Nov. 2018, [Peer-reviewed]
Scientific journal

Correlation of physical function with the thickness of multiple muscles of the quadriceps femoris in community-dwelling elderly individuals
Ken Nishihara; Hisashi Kawai; Takeshi Kera; Hirohiko Hirano; Yutaka Watanabe; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Masashi Tanaka; Shuichi Obuchi
Clinical Interventions in Aging, Volume 13, 1945, 1951, Dove Medical Press Ltd., Oct. 2018, [Peer-reviewed]
Scientific journal

Relationship between masticatory function and frailty in community-dwelling Japanese elderly
Yasuhiro Horibe; Yutaka Watanabe; Hirohiko Hirano; Ayako Edahiro; Ken Ishizaki; Takayuki Ueda; Kaoru Sakurai
Aging Clinical and Experimental Research, 30, 9, 1093, 1099, Springer Nature, Sep. 2018, [Peer-reviewed], [Corresponding author]
Scientific journal

The relationship between masseter muscle thickness and appendicular skeletal muscle mass in Japanese community-dwelling elders: A cross-sectional study
Kento Umeki; Yutaka Watanabe; Hirohiko Hirano; Ayako Edahiro; Yuki Ohara; Hideyo Yoshida; Shuichi Obuchi; Hisashi Kawai; Masaharu Murakami; Daisuke Takagi; Kazushige Ihara; Kentaro Igarashi; Masayasu Ito; Yasuhiko Kawai
Archives of Gerontology and Geriatrics, 78, 18, 22, Elsevier {BV}, Sep. 2018, [Peer-reviewed], [Corresponding author]
Scientific journal

Factors related to dissociation between objective and subjective masticatory function in Japanese community-dwelling elderly adults
M. Murakami; Y. Watanabe; A. Edahiro; Y. Ohara; S. Obuchi; H. Kawai; H. Kim; Y. Fujiwara; K. Ihara; M. Murakami; H. Hirano
Journal of Oral Rehabilitation, 45, 8, 598, 604, Wiley, Aug. 2018, [Peer-reviewed]
Scientific journal

Factors affecting the appetites of persons with Alzheimer's disease and mild cognitive impairment
Shino Suma; Yutaka Watanabe; Hirohiko Hirano; Ai Kimura; Ayako Edahiro; Shuichi Awata; Yoshihisa Yamashita; Kenji Matsushita; Hidenori Arai; Takashi Sakurai
Geriatrics & Gerontology International, 18, 8, 1236, 1243, Wiley, Aug. 2018, [Peer-reviewed], [Corresponding author]
Scientific journal

Comparison of body composition and physical and cognitive function between older Japanese adults with no diabetes, prediabetes and diabetes: A cross-sectional study in community-dwelling Japanese older people
Takeshi Kera; Hisashi Kawai; Hirohiko Hirano; Motonaga Kojima; Yutaka Watanabe; Yoshinori Fujiwara; Kazushige Ihara; Shuichi Obuchi
Geriatrics & Gerontology International, 18, 7, 1031, 1037, Wiley, Jul. 2018, [Peer-reviewed]
Scientific journal

Oral function as an indexing parameter for mild cognitive impairment in older adults
Yutaka Watanabe; Hidenori Arai; Hirohiko Hirano; Shiho Morishita; Yuki Ohara; Ayako Edahiro; Masaharu Murakami; Hiroyuki Shimada; Takeshi Kikutani; Takao Suzuki
Geriatrics & Gerontology International, 18, 5, 790, 798, Wiley, May 2018, [Peer-reviewed], [Lead author]
Scientific journal

Frailty Severity and Dietary Variety in Japanese Older Persons: A Cross-Sectional Study
K. Motokawa; Yutaka Watanabe; A. Edahiro; M. Shirobe; M. Murakami; T. Kera; H. Kawai; S. Obuchi; Y. Fujiwara; K. Ihara; Y. Tanaka; H. Hirano
Journal of Nutrition, Health and Aging, 22, 3, 451, 456, Springer-Verlag France, 01 Mar. 2018, [Peer-reviewed], [Corresponding author]
English, Scientific journal

Response to comments on: Development of an oral health-related self-efficacy scale for use with older adults
Yuki Ohara; Naomi Yoshida; Hisashi Kawai; Shuichi Obuchi; Shiro Mataki; Hirohiko Hirano; Yutaka Watanabe
Geriatrics & Gerontology International, 18, 3, 514, 515, Wiley, Mar. 2018, [Peer-reviewed]
Scientific journal

Development of the Japanese version of the Council on Nutrition Appetite Questionnaire and its simplified versions, and evaluation of their reliability, validity, and reproducibility
Yuko Tokudome; Keiko Okumura; Yoshiko Kumagai; Hirohiko Hirano; Hunkyung Kim; Shiho Morishita; Yutaka Watanabe
JOURNAL OF EPIDEMIOLOGY, 27, 11, 524, 530, Nov. 2017, [Peer-reviewed]
English, Scientific journal

Development of an oral health-related self-efficacy scale for use with older adults
Yuki Ohara; Naomi Yoshida; Hisashi Kawai; Shuichi Obuchi; Hideyo Yoshida; Shiro Mataki; Hirohiko Hirano; Yutaka Watanabe
GERIATRICS & GERONTOLOGY INTERNATIONAL, 17, 10, 1406, 1411, Oct. 2017, [Peer-reviewed]
English, Scientific journal

Factors affecting masticatory function of community-dwelling older people: Investigation of the differences in the relevant factors for subjective and objective assessment
Daisuke Takagi; Yutaka Watanabe; Ayako Edahiro; Yuki Ohara; Masaharu Murakami; Kohji Murakami; Shouji Hironaka; Yu Taniguchi; Akihiko Kitamura; Shoji Shinkai; Hirohiko Hirano
GERODONTOLOGY, 34, 3, 357, 364, Sep. 2017, [Peer-reviewed], [Corresponding author]
English, Scientific journal

Relationship between skeletal muscle mass and swallowing function in patients with Alzheimer's disease
Daisuke Takagi; Hirohiko Hirano; Yutaka Watanabe; Ayako Edahiro; Yuki Ohara; Hideyo Yoshida; Hunkyung Kim; Kohji Murakami; Shouji Hironaka
GERIATRICS & GERONTOLOGY INTERNATIONAL, 17, 3, 402, 409, Mar. 2017, [Peer-reviewed]
English, Scientific journal

Oral function and nutritional status among the elderly with facial and oral tactile hypersensitivity who are under long-term care.
Shirobe M; Nakayama R; Hirano H; Ohara Y; Endo K; Watanabe Y; Hakuta C
[Nihon koshu eisei zasshi] Japanese journal of public health, 64, 7, 351, 358, 2017, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, Objective In oral health care, a refusal action can cause difficulties, and tactile hypersensitivity (TH) may be a contributing factor. People with TH of the face and mouth clench their jaws. Despite numerous reports on TH among children with disabilities, reports on TH in the elderly who are under long-term care are scarce. The purpose of this study was to investigate TH among the elderly who are under long-term care.Methods We selected 80 residents (8 men and 72 women; mean age: 91.1±6.2y) in a Tokyo nursing home and investigated the presence of TH in them. We also obtained patients' (1) basic information (sex, age, stage of long-term care needs (SCN), and the degree of independent living (IL)); (2) oral information (swallowing status, choking tendency, and intraoral residue); and (3) nutritional information (serum albumin (Alb) levels and body mass index (BMI)). We assessed the face (the forehead, cheek, and perioral area) and the intraoral environment (buccal mucosa, buccal cavity, and palate) as testing sites for TH, using the tester's palm and forefinger. We confirmed the presence of TH when the tested areas reacted partially or fully by shuddering. We classified the subjects into 2 groups based on the presence or absence of TH and analyzed our results using a chi-square test and Mann-Whitney U test. This investigation was approved by the Dentistry Ethics Screening Committee, Tokyo Medical and Dental University.Results A total of 18 residents were diagnosed with TH (22.5%). Significant differences in SCN, IL, choking tendency, intraoral residue, swallowing status, serum Alb levels, and BMI (P<0.05) were reported between this group and the non-TH group.Conclusion We demonstrated that residents with TH were in an advanced SCN and had a lower IL score and a decreased swallowing and nutritional status. Therefore, oral health care, promotion of nutritional status, and meal support are particularly important for the elderly with TH.

Relationship Between Frailty and Oral Function in Community-Dwelling Elderly Adults
Yutaka Watanabe; Hirohiko Hirano; Hidenori Arai; Shiho Morishita; Yuki Ohara; Ayako Edahiro; Masaharu Murakami; Hiroyuki Shimada; Takeshi Kikutani; Takao Suzuki
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 65, 1, 66, 76, Jan. 2017, [Peer-reviewed], [Lead author]
English, Scientific journal

Factors associated with older adults' need for oral hygiene management by dental professionals
Shiho Morishita; Yutaka Watanabe; Yuki Ohara; Ayako Edahiro; Emiko Sato; Takeo Suga; Hirohiko Hirano
GERIATRICS & GERONTOLOGY INTERNATIONAL, 16, 8, 956, 962, Aug. 2016, [Peer-reviewed]
English, Scientific journal

Sarcopenia: Prevalence and associated factors based on different suggested definitions in community-dwelling older adults
Hunkyung Kim; Hirohiko Hirano; Ayako Edahiro; Yuki Ohara; Yutaka Watanabe; Narumi Kojima; Miji Kim; Erika Hosoi; Yuko Yoshida; Hideyo Yoshida; Shoji Shinkai
GERIATRICS & GERONTOLOGY INTERNATIONAL, 16, 110, 122, Mar. 2016, [Peer-reviewed]
English

An examination of factors related to aspiration and silent aspiration in older adults requiring long-term care in rural Japan
K. Sakai; H. Hirano; Y. Watanabe; H. Tohara; E. Sato; K. Sato; A. Katakura
Journal of Oral Rehabilitation, 43, 2, 103, 110, Blackwell Publishing Ltd, 01 Feb. 2016, [Peer-reviewed]
English, Scientific journal

Association between the nutritional status and the severity of sarcopenia among community-dwelling elderly Japanese people
Satsuki Komai; Yutaka Watanabe; Yoshinori Fujiwara; Hunkyung Kim; Ayako Edahiro; Hisashi Kawai; Hideyo Yoshida; Shuichi Obuchi; Yayoi Tanaka; Hirohiko Hirano
Japanese Journal of Geriatrics, 53, 4, 387, 395, Japan Geriatrics Society, 2016, [Peer-reviewed]
Japanese, Scientific journal

The need and availability of dental services for terminally ill cancer patients: a nationwide survey in Japan
Tomohisa Ohno; Tatsuya Morita; Fumiyo Tamura; Hirohiko Hirano; Yutaka Watanabe; Takeshi Kikutani
SUPPORTIVE CARE IN CANCER, 24, 1, 19, 22, Jan. 2016, [Peer-reviewed]
English, Scientific journal

Relationship between swallowing function and the skeletal muscle mass of older adults requiring long-term care
Kohji Murakami; Hirohiko Hirano; Yutaka Watanabe; Ayako Edahiro; Yuki Ohara; Hideyo Yoshida; Hunkyung Kim; Daisuke Takagi; Shouji Hironaka
GERIATRICS & GERONTOLOGY INTERNATIONAL, 15, 10, 1185, 1192, Oct. 2015, [Peer-reviewed]
English, Scientific journal

Relationship between chewing ability and sarcopenia in Japanese community-dwelling older adults
Masaharu Murakami; Hirohiko Hirano; Yutaka Watanabe; Katsuhiko Sakai; Hunkyoung Kim; Akira Katakura
GERIATRICS & GERONTOLOGY INTERNATIONAL, 15, 8, 1007, 1012, Aug. 2015, [Peer-reviewed]
English, Scientific journal

認知症患者の歯科的対応および歯科治療のあり方 学会の立場表明2015
枝広 あや子; 渡邊 裕; 平野 浩彦; 古屋 純一; 中島 純子; 田村 文誉; 北川 昇; 堀 一浩; 原 哲也; 吉川 峰加; 西 恭宏; 永尾 寛; 服部 佳功; 市川 哲雄; 櫻井 薫; 日本老年歯科医学会ガイドライン委員会
老年歯科医学, 30, 1, 3, 11, (一社)日本老年歯科医学会, Jun. 2015, [Peer-reviewed]
Japanese

Factors associated with self-rated oral health among community-dwelling older Japanese: A cross-sectional study
Yuki Ohara; Hirohiko Hirano; Yutaka Watanabe; Shuichi Obuchi; Hideyo Yoshida; Yoshinori Fujiwara; Kazushige Ihara; Hisashi Kawai; Shiro Mataki
GERIATRICS & GERONTOLOGY INTERNATIONAL, 15, 6, 755, 761, Jun. 2015, [Peer-reviewed]
English, Scientific journal

How masticatory function and periodontal disease relate to senile dementia
Yutaka Watanabe; Hirohiko Hirano; Kenji Matsushita
JAPANESE DENTAL SCIENCE REVIEW, 51, 1, 34, 40, Feb. 2015, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
English, Scientific journal

Effects of professional oral health care on reducing the risk of chemotherapy-induced oral mucositis
Hirokazu Saito; Yutaka Watanabe; Kazumichi Sato; Hiroaki Ikawa; Yoshifumi Yoshida; Akira Katakura; Shin Takayama; Michio Sato
SUPPORTIVE CARE IN CANCER, 22, 11, 2935, 2940, Nov. 2014, [Peer-reviewed]
English, Scientific journal

Detecting signs of dysphagia in patients with Alzheimer's disease with oral feeding in daily life
Emiko Sato; Hirohiko Hirano; Yutaka Watanabe; Ayako Edahiro; Kazumichi Sato; Genyuki Yamane; Akira Katakura
GERIATRICS & GERONTOLOGY INTERNATIONAL, 14, 3, 549, 555, Jul. 2014, [Peer-reviewed]
English, Scientific journal

脳卒中患者の歯科治療時のリスク評価に関する研究
森戸 光彦; 渡邊 裕; 菅 武雄; 片倉 朗; 片山 正輝; 戸原 玄; 吉田 光由
日本歯科医学会誌, 33, 59, 63, 日本歯科医学会, Mar. 2014, [Peer-reviewed]
Japanese

Mirror neurons activated during swallowing and finger movements: An fMRI study
Motoi Ogura; Yutaka Watanabe; Yusuke Sanjo; Ayako Edahiro; Kazumichi Sato; Akira Katakura
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 26, 2, 188, 197, Elsevier Ltd, 2014, [Peer-reviewed]
English, Scientific journal

Ventilator-associated pneumonia risk decreased by use of oral moisture gel in oral health care.
Takeyasu Y; Yamane GY; Tonogi M; Watanabe Y; Nishikubo S; Serita R; Imura K
The Bulletin of Tokyo Dental College, 55, 2, 95, 102, Tokyo Dental College, Japan, 2014, [Peer-reviewed]
English, Although oral health care has a preventive effect against ventilator-associated pneumonia (VAP), the most effective method of oral health care in this respect remains to be established. The objective of this single-center, randomized, controlled trial was to investigate the relationship between VAP and various methods of oral health care. All patients included in the study (n=142) were on mechanical ventilation with oral intubation at the intensive care unit of the Tokyo Dental College Ichikawa General Hospital. They were divided into two groups, one receiving standard oral health care (Standard group), and the other receiving oral health care using an oral moisture gel instead of water (Gel group). After removal of the intubation tube, biofilm on cuff of the tube was stained with a disclosing agent to determine the contamination level. Factors investigated included sex, age, number of remaining teeth, intubation time, fever ≥38.5°C, VAP, cuff contamination level, and time required for one oral health care session. No VAP occurred in either group during the study period. The level of cuff contamination was significantly lower in the Gel group than the Standard group, and the time required for one session of oral health care was shorter (p<0.001). Multivariate analysis revealed use of the oral moisture gel as a factor affecting cuff contamination level. Use of an oral moisture gel decreased invasion of the pharynx by bacteria andcontaminants together with biofilm formation on the intubation tube cuff. These results suggest that oral health care using an oral moisture gel is effective in preventing cuff contamination.

アルツハイマー病と血管性認知症高齢者の食行動の比較に関する調査報告(第一報) 食行動変化について
枝広 あや子; 平野 浩彦; 山田 律子; 千葉 由美; 渡邊 裕
日本老年医学会雑誌, 50, 5, 651, 660, (一社)日本老年医学会, Sep. 2013, [Peer-reviewed]
Japanese, 施設入所中の認知症高齢者のうちアルツハイマー病(AD)150例、血管性認知症(VaD)83例を対象に、認知症の重症度別で食事に関する行動障害を比較検討した。その結果、食事に関連した行動障害は重度認知症の者ほど増加傾向が示された。「リンシング・ガーグリング困難」「嚥下障害の徴候」の認知症重症度別の出現頻度は、ADとVaDで有意差がみられた。重症認知症では、ADは食事開始困難や注意維持困難、巧緻性低下など認知機能障害の影響が大きい項目の出現が顕著にみられた。VaDの食事に関連した行動障害と嚥下障害は、認知症の重症度とは関連がみられず、軽度認知症でも神経脱落症状に起因した嚥下障害が示された。

顎関節症患者のいびきと就寝体位に関する検討
佐藤 一道; 吉田 佳史; 浮地 賢一郎; 有坂 岳大; 宇治川 清登; 武安 嘉大; 高田 篤史; 渡邊 裕; 小澤 靖弘; 山根 源之; 片倉 朗; 栗山 智宏; 外木 守雄
日本歯科人間ドック学会誌, 8, 1, 30, 34, (一社)ジャパンオーラルヘルス学会, Aug. 2013, [Lead author]
Japanese

Masseter muscle tension and chewing ability in older persons
Yuki Ohara; Hirohiko Hirano; Yutaka Watanabe; Ayako Edahiro; Emiko Sato; Shoji Shinkai; Hiroto Yoshida; Shiro Mataki
Geriatrics and Gerontology International, 13, 2, 372, 377, Apr. 2013, [Peer-reviewed]
English, Scientific journal

東京歯科大学市川総合病院の呼吸ケアチームにおける歯科衛生士のアプローチ
多比良 祐子; 清住 沙代; 高柳 奈見; 藤平 弘子; 西久保 周一; 渡邊 裕; 松崎 達; 芹田 良平; 片倉 朗
歯科学報, 113, 1, 47, 56, 東京歯科大学学会, Feb. 2013, [Peer-reviewed]
Japanese

Comparative study of eating behavior in elderly patients with Alzheimer's disease and vascular dementia: A first report. -Comparison of disturbed eating behavior
Ayako Edahiro; Hirohiko Hirano; Ritsuko Yamada; Yumi Chiba; Yutaka Watanabe
Japanese Journal of Geriatrics, 50, 5, 651, 660, 2013, [Peer-reviewed]
Japanese, Scientific journal

Visual and Auditory Stimuli Associated with Swallowing Activate Mirror Neurons: A Magnetoencephalography Study
Takashi Ushioda; Yutaka Watanabe; Yusuke Sanjo; Gen-yuki Yamane; Shinichi Abe; Yusuke Tsuji; Atushi Ishiyama
DYSPHAGIA, 27, 4, 504, 513, Dec. 2012, [Peer-reviewed]
English, Scientific journal

Gene and protein expressions of vimentin and desmin during embryonic development of the mylohyoid muscle
Asuka Kishi; Masahito Yamamoto; Akihito Kikuchi; Osamu Iwanuma; Yutaka Watanabe; Yoshinobu Ide; Shinichi Abe
ANATOMICAL SCIENCE INTERNATIONAL, 87, 3, 126, 131, Sep. 2012, [Peer-reviewed]
English, Scientific journal

Factors affecting independence in eating among elderly with Alzheimer's disease
Ayako Edahiro; Hirohiko Hirano; Ritsuko Yamada; Yumi Chiba; Yutaka Watanabe; Morio Tonogi; Gen-yuki Yamane
GERIATRICS & GERONTOLOGY INTERNATIONAL, 12, 3, 481, 490, Jul. 2012, [Peer-reviewed]
English, Scientific journal

摂食・嚥下障害に対する舌接触補助床の有効性
植田 耕一郎; 向井 美恵; 森田 学; 菊谷 武; 渡邊 裕; 戸原 玄; 阿部 仁子; 中山 渕利; 佐藤 光保; 井上 統温; 飯田 貴俊; 和田 聡子
日本摂食・嚥下リハビリテーション学会雑誌, 16, 1, 32, 41, (一社)日本摂食嚥下リハビリテーション学会, Apr. 2012, [Peer-reviewed]
Japanese

口腔乾燥の評価ならびにガイドラインの検討
森戸 光彦; 山本 健; 菅 武雄; 野村 義明; 山根 源之; 渡邊 裕; 北川 昇; 岡根 百江
日本歯科医学会誌, 31, 59, 63, 日本歯科医学会, Mar. 2012, [Peer-reviewed]
Japanese

舌癌術後の創部に生じた唾石症の1例(A Case of Sialolithiasis Occurring in the Wound Area Following Surgery for Tongue Cancer)
黒川 貴史; 渡邊 伸也; 佐藤 一道; 渡邊 裕; 山内 智博; 外木 守雄; 山根 源之; 田中 陽一; 片倉 朗
日本口腔診断学会雑誌, 25, 1, 108, 111, (一社)日本口腔診断学会, Feb. 2012, [Peer-reviewed]
English

Risk factors for postoperative dysphagia in oral cancer.
Yamauchi T; Edahiro A; Watanabe Y; Murakami M; Satou E; Saito H; Sanjo Y; Sakai K; Takaki S; Kamiyama I; Hanaue N; Satou K; Tonogi M; Katakura A; Shibahara T; Yamane GY
The Bulletin of Tokyo Dental College, 53, 2, 67, 74, 2012, [Peer-reviewed]
Scientific journal

Factor analysis on oral health care for acute hospitalized patients in Japan
Chika Kuramoto; Yutaka Watanabe; Morio Tonogi; Soichiro Hirata; Naoki Sugihara; Takuo Ishii; Gen-yuki Yamane
GERIATRICS & GERONTOLOGY INTERNATIONAL, 11, 4, 460, 466, Oct. 2011, [Peer-reviewed]
English, Scientific journal

PBLに準じたsmall group discussion(SGD)と実習に基づく摂食・嚥下リハビリテーションの卒前カリキュラム
大久保 真衣; 石田 瞭; 杉山 哲也; 渡邊 裕; 片倉 朗; 中野 洋子; 石崎 憲; 白鳥 たかみ; 久保 周平; 阿部 伸一; 田崎 雅和; 一戸 達也
歯科学報, 111, 4, 326, 333, 東京歯科大学学会, Aug. 2011, [Peer-reviewed]
Japanese

東京歯科大学市川総合病院歯科・口腔外科における平成21年度初診患者の臨床統計
栗山 智宏; 西久保 周一; 浮地 賢一郎; 有坂 岳大; 宇治川 清登; 武安 嘉大; 高田 篤史; 渡邊 裕; 外木 守雄; 山根 源之
歯科学報, 111, 2, 185, 194, 東京歯科大学学会, Apr. 2011, [Peer-reviewed]
Japanese

医療面接の重要性の検討
羽田有沙; 栗山智宏; 山崎喜範; 渡邊裕; 森本光明; 外木守雄; 山根源之
日本口腔診断学会雑誌, 24, 14, 19, 2011, [Peer-reviewed]

高齢者糖尿病患者に対する歯科衛生士介入方法についての検討(第1報) 糖尿病の病態と口腔衛生状態
清住沙代; 雨宮智美; 大屋朋子; 多比良祐子; 高柳奈見; 奥井沙織; 馬場里奈; 藤平弘子; 相川真澄; 並木修司; 會田貴久; 酒井克彦; 山崎喜範; 蔵本千夏; 渡邊裕; 外木守雄; 武井泉; 山根源之
老年歯科医学, 25, 4, 382, 386, (一社)日本老年歯科医学会, 2011, [Peer-reviewed]
Japanese

A case of drug-induced hypersensitivity syndrome due to carbamazepine.
Morimoto M; Watanabe Y; Arisaka T; Takada A; Tonogi M; Yamane GY; Fukushima D; Takahashi S; Tanaka Y
The Bulletin of Tokyo Dental College, 52, 3, 135, 142, 2011, [Peer-reviewed], [Corresponding author], [Domestic magazines]
English, Scientific journal, The patient was a 51-year-old man who had been prescribed carbamazepine for right third-branch trigeminal neuralgia. He had stopped taking the medication after the neuralgia resolved. When the neuralgia recurred, he resumed medication, and about 1 month later he developed fever, fatigue, cervical lymphadenopathy, generalized skin flushing, facial edema and perioral vesicles, and was admitted to Ichikawa General Hospital, Tokyo Dental College. Oral findings showed reddening and erosion of the buccal mucosa. Routine laboratory examination revealed leukocytosis and hepatic dysfunction. Human herpesvirus 6 antibody titer remarkably increased during development of eruptions. These findings led to a diagnosis of drug-induced hypersensitivity syndrome. Carbamazepine was discontinued, and prednisolone (30 mg/day) was started and tapered based on improvement of symptoms. Because skin symptoms recurred after he was discharged 15 days after admission, the dose of prednisolone was increased and the symptoms finally disappeared. The patient has experienced no further recurrence.

Expression of HGF and IGF-1 during regeneration of masseter muscle in mdx mice
Hidemitsu Honda; Shinichi Abe; Ryo Ishida; Yutaka Watanabe; Osamu Iwanuma; Koji Sakiyama; Yoshinobu Ide
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 31, 1, 71, 77, Jul. 2010, [Peer-reviewed]
English, Scientific journal

他臓器に未治療癌を有した高齢者に生じた口腔癌に対する治療経験
伊川裕明; 佐藤一道; 齋藤寛一; 會田貴久; 内田淳; 渡邊裕; 外木守雄; 神山勲; 山内智博; 片倉朗; 田中陽一; 山根源之
老年歯科医学, 25, 3, 322, 326, (一社)日本老年歯科医学会, 2010, [Peer-reviewed]
Japanese

摂食・嚥下障害に対する機能改善のための義歯型補助具の普及性
植田耕一郎; 向井美惠; 森田学; 菊谷武; 相田潤; 渡邊裕; 戸原玄; 中山渕利; 佐藤光保; 井上統温; 飯田貴俊; 和田聡子
老年歯科医学, 25, 2, 123, 130, (一社)日本老年歯科医学会, 2010, [Peer-reviewed]
Japanese

高齢者における咀嚼機能と脳機能、高齢者の口腔機能とケア
渡邊 裕
Advances in Aging and Health Research 2009, 97, 106, 2010, [Peer-reviewed], [Lead author, Corresponding author]

A Case of Primary Unknown Squamous Cell Carcinoma thought to be Branchiogenic Carcinoma
Yutaka WATANABE; Takashi USHIODA; Keiko; YAMAMURA; Tomohiro YAMAUCHI; Yasuhiro OZAWA; Morio TONOGI; Gen-yuki YAMANE、AND Yoichi TANAKA
Jpn J Oral Diag/Oral Med, 23, 1, 176, 180, 2010, [Peer-reviewed], [Lead author, Corresponding author]

新しい在宅歯科医療を支える地域における先進事例の調査
菊谷 武; 田村文誉; 木村年秀; 角町正勝; 渡邊 裕; 山根源之; 細野 純; 佐々木勝忠; 米山武義; 菅 武雄; 森戸光彦
日歯医学会誌, 29, 77, 81, 2010, [Peer-reviewed]

地域医療連携と口腔機能管理～病院完結型医療から地域完結型医療へ～
渡邊裕; 山根源之
8020財団会誌, 8, 72, 77, 2009, [Lead author]

Dental Hygienist's Role in Regional Alliances NST : Example of dental hygienist playing central role
OHYA Tomoko; TAHIRA Yuko; AMEMIYA Tomomi; KIYOSUMI Sayo; TAKAYANAGI Nami; OKUI Saori; MAEDA Ai; BABA Rina; FUJIHIRA Hiroko; HATA Arisa; YAZAKI Ryoko; EDAHIRO Ayako; HANAUE Nobuaki; WATANABE Yutaka; YAMAUCHI Tomohiro; TONOGI Morio; NAKAHAMA Takashi; SATO Michio; NAKAJIMA Tsuneya; YAMANE Genyuki
歯科学報, 109, 2, 185, 191, 東京歯科大学学会, 2009, [Peer-reviewed]
Japanese

Visual and auditory stimuli associated with swallowing: an FMRI study.
Kawai T; Watanabe Y; Tonogi M; Yamane GY; Abe S; Yamada Y; Callan A
The Bulletin of Tokyo Dental College, 50, 4, 169, 181, 2009, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, We focused on brain areas activated by audiovisual stimuli related to swallowing motions. In this study, three kinds of stimuli related to human swallowing movement (auditory stimuli alone, visual stimuli alone, or audiovisual stimuli) were presented to the subjects, and activated brain areas were measured using fMRI and analyzed. When auditory stimuli alone were presented, the supplementary motor area was activated. When visual stimuli alone were presented, the premotor and primary motor areas of the left and right hemispheres and prefrontal area of the left hemisphere were activated. When audiovisual stimuli were presented, the prefrontal and premotor areas of the left and right hemispheres were activated. Activation of Broca's area, which would have been characteristic of mirror neuron system activation on presentation of motion images, was not observed; however, activation of brain areas related to swallowing motion programming and performance was verified for auditory, visual and audiovisual stimuli related to swallowing motion. These results suggest that audiovisual stimuli related to swallowing motion could be applied to the treatment of patients with dysphagia.

高カリウム血性周期性四肢麻痺患者の顎矯正手術における周術期管理
羽田有沙; 枝広あや子; 森下仁史; 多田和弘; 渡邊裕; 外木守雄; 山根源之; 縣秀栄; 小板橋俊哉; 野川 茂
歯科学報, 108, 6, 637, 643, 2008, [Peer-reviewed]

摂食・嚥下 歯科医が行うリハ 歯科医が行う摂食・嚥下リハビリテーション
渡邊裕; 枝広あや子; 山根源之
歯科臨床研究, 5, 2, 28, 38, 2008, [Peer-reviewed]

東京歯科大学市川総合病院 栄養サポートチームにおける病診連携の可能性
花上伸明; 渡邊裕; 矢崎涼子; 山内智博; 中濱孝志; 中本未央; 末盛賢司; 貝田将郷; 佐藤道夫; 外木守雄; 中島庸也; 田中葉子; 高橋正憲; 山根源之; 安藤暢敏
歯科学報, 108, 1, 59, 65, 2008, [Peer-reviewed]

Inverse solution for time-correlated multiple sources using Beamformer method
Takeshi Kimura; Masahiro Kako; Hiromi Kamiyama; Atsushi Ishiyama; Naoko Kasai; Yutaka Watanabe
International Congress Series, 1300, 417, 420, Jun. 2007, [Peer-reviewed]
English, International conference proceedings

An FMRI study of visual and auditory stimuli associated with swallowing
yutaka watanabe
Dysphagia, 2007
Scientific journal

歯列模型による自覚症状の再現が治療上有効であった口腔内セネストパチーの1例
潮田高志; 渡邊裕; 森本光明; 外木守雄; 山根源之; 吉野文浩
日本歯科心身医学会雑誌, 22, 2, 94, 97, 2007, [Peer-reviewed]

Evaluation of epithelial dysplasia at the surgical margins in patients with early tongue carcinoma - Immunohistochemical study of recurrence of epithelial dysplasia
Yuichiro Okazaki; Kazumichi Sato; Atsushi Takada; Shigeki Morisaki; Yutaka Watanabe; Yasuhiro Ozawa; Mitsuaki Morimoto; Morio Tonogi; Yoichi Tanaka; Gen-Yuki Yamane
Asian Journal of Oral and Maxillofacial Surgery, 19, 2, 89, 95, Scientific Communications International Ltd, 2007, [Peer-reviewed]
English, Scientific journal

Clinical Study of the Autologous Bone Grafting in Oral Functional Reconstruction
Ozawa,Y; Hanaue,N; Sato,K; Takada,A; Okazaki,Y; Watanabe,Y; Kuramoto,C; Kizu,Y; Morimoto,M; Tonogi,M; Yamane,G
Jpn J Oral Diag/Oral Med, 20, 429, 435, 2007, [Peer-reviewed]

Clinical study of pediatric patients visiting the oral and maxillofacial surgery emergency unit
NISHIKUBO Shuichi; HANAUE Nobuaki; TAKADA Atsushi; MORISAKI Shigeki; WATANABE Yutaka; TONOGI Morio; YAMANE Gen-yuki
POMS, 17, 2, 85, 89, JAPANESE SOCIETY OF PEDIATRIC ORAL AND MAXILLOFACIAL SURGERY, 2007, [Peer-reviewed]
A clinical study was performed for pediatric patients with oral and maxillofacial lesions who visited the emergency unit of the oral and maxillofacial surgery section of Tokyo Dental College, Ichikawa General Hospital between April 2004 and March 2006.
Six hundred and sixty-nine pediatric oral and maxillofacial emergency patients have attended the section for two years. The ratio of the male to the female were 1.4: 1. By age distribution, 1-year-olds showed the highest incident of injuries (155 cases, 23%). The most common cause of oral and maxillofacial injury was fall (293 cases, 44%). The most common injury of soft tissue was lower lip (87 cases, 20%). The time of visiting the clinics showed a peak at 21: 00.

咀嚼と嚥下
渡邊裕
日本全身咬合学会雑誌, 13, 2, 129, 134, 2007, [Peer-reviewed], [Invited], [Lead author, Corresponding author]

Case of accidental insertion of broken injection needle during local infiltration anesthesia
OKAZAKI Yuichiro; HANAUE Nobuaki; SATO Kazumichi; TAKADA Atsushi; MORISAKI Shigeki; KURAMOTO Chika; WATANABE Yutaka; OZAWA Yasuhiro; MORIMOTO Mitsuaki; TONOGI Morio; YAMANE Gen-yuki
歯科学報, 107, 3, 331, 335, 東京歯科大学学会, 2007, [Peer-reviewed]
Japanese

栄養ケア・マネジメントにおける歯科の役割
菊谷武; 吉田光由; 菅武雄; 渡邊裕; 藤本篤士; 石飛進吾; 田村文誉; 赤川安正; 森戸光彦; 大井久美子; 山根源之
日本歯科医学会誌, 26, 36, 41, 2007, [Peer-reviewed]

[Oral care for elderly people].
Yamane GY; Watanabe Y; Tonogi M
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 44, 1, 1, 10, Jan. 2007, [Peer-reviewed], [Invited]

Survey on inpatient oral health care by nurses : Based on questionnaire to nurses
ITABA Reiko; OKUI Saori; GOHARA Ai; TAKESITA Youko; BABA Rina; IWASAKI Miwa; FUJIHIRA Hiroko; TAKAGI Sachiko; OTUKA Hiroshi; KURAMOTO Chika; WATANABE Yutaka; TONOKI Morio; YAMANE Gen-yuki; SONODA Michiko; ADACHI Tomiko; SUZUKI Fukuyo; SUGIHARA Naoki; MATSUKUBO Takashi
齒科學報, 106, 4, 267, 272, 東京歯科大学学会, 30 Aug. 2006, [Peer-reviewed]
Japanese

在宅医療におけるNST（栄養サポートチーム）の活用と病診連携の可能性「咀嚼・嚥下機能とNSTの役割」
渡邊 裕; 花上伸明; 田中葉子; 中濱孝志; 末盛賢司
日在医会誌, 8, 62, 65, 2006, [Peer-reviewed], [Lead author, Corresponding author]

当院における睡眠時無呼吸低呼吸症候群に対する口腔内装置による治療の現状
塚本裕介; 有坂岳大; 栗山智宏; 森下仁史; 佐藤一道; 渡邊裕; 外木守雄; 山根源之; 大櫛哲史; 葉山貴司; 中島庸也; 大川登史; 宮内潤
歯科学報, 106, 3, 236, 242, 東京歯科大学学会, 2006, [Peer-reviewed]
Japanese

Oral Care of the Patients with Tracheal Intubation
WATANABE Yutaka; YAMANE Gen-yuki; TONOGI Morio; KURAMOTO Chika
老年歯科医学, 20, 4, 362, 369, 2006, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
Japanese

Survey on Oral Health Care for Elderly in Long-term Care Insurance Facilities : Part 1 Current Status of Oral Heath Care and Dental Health Personnel's Part in Oral Health Care
ISHII Takuo; OKADA Mahito; OKAWA Yoshikazu; WATANABE Yutaka; KURAMOTO Chika; YAMADA Yoshihiro; OHARA Satoko; SHINSHO Fumiaki; YAMANE Gen-yuki; MIYATAKE Koukichi
Journal of dental health, 56, 2, 178, 186, The Japanese Society for Dental Health, 2006, [Peer-reviewed]
Japanese, In Japan, many dependent elderly people living in long-term care insurance (LTCI) facilities nave acute histories of cerebrovascular accident. The purpose of this study was to investigate the current status and management of oral health care for elderly people residing in LTCI facilities. We selected 15,722 LTCI facilities through the internet homepage "U-raku", which is a welfare information network, using four key phrases: "Welfare facilities for elderly people requiring nursing care", "Health facilities for elderly people requiring nursing care", "Medical institutions for recuperation through nursing care", and "Group home". A random sampling of 1,000 facilities was carried out for each category of institution. A questionnaire was then mailed to 4,000 LTCI facilities to be returned by mail (n=1,713, response rate=42.8%). The results showed that 91.4% of fundamental care plans in LTCI facilities included oral health care; however, an actual check on how oral health care was being implemented revealed a rate of approximately once per month in the majority of facilities. A large number of care personnel in LTCI facilities were in charge of checking on oral health care. The LTCI facility staff, however, had received little education on oral health and related issues in their training. The response to a question on oral health care showed that the number of patients receiving treatment from visiting dentists was about the same as the number of residents visiting dental clinics. The results of this study suggest that dental health personnel should work together with care personnel to provide regular oral health care for elderly people in LTCI facilities.

The factors which influence MRSA infection and the effects of oral health care on the dependent elderly
Tonogi M; Yamane G; Ozawa Y; Kuramoto C; Watanabe Y; Takada A; Otuka Y; Takeyasu Y; Ushioda T; Hotate H
Dentistry in Japan,, 41, 214, 220, 2005, [Peer-reviewed]

形態,機能から咀嚼・嚥下障害を考える
渡邊裕
日本全身咬合学会雑誌, 11, 2, 121, 127, 2005, [Peer-reviewed], [Invited], [Lead author, Corresponding author]

A case of advanced rhabdomyosarcoma in the pterygopalatine fossa successfully treated by combined chemotherapy with cisplatin and caffeine
SATO Kazumichi; TONOGI Morio; WATANABE Yutaka; KURAMOTO Chika; TANAKA Yoichi; YAMANE Gen-yuki
Journal of Oral Surgery Society of Japan, 51, 4, 192, 195, Japanese Society of Oral and Maxillofacial Surgeons, 2005, [Peer-reviewed]
Japanese, We report a case of rhabdomyosarcoma (RMS) that was successfully treated by combined chemotherapy with cisplatin and caffeine. This case was characterized by resistance to treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy and irradiation of carbon ions by an heavy ion medical accelerator in Chiba (HIMAC).
We describe an 18-year-old man with a local recurrent RMS that developed after CHOP chemotherapy and HIMAC irradiation. The patient had undergone partial resection for a recurrent huge tumor near the pterygopalatine fossa. Tumor proliferation occurred after the first operation; therefore, partial resection was planned again. Cisplatin combined with caffeine was given as preoperative chemotherapy for the second partial resection because CHOP chemotherapy had been ineffective. The RMS responded remarkably to cisplatin combined with caffeine, both macroscopically and histologically. The treatment was adequately effective as preoperative chemotherapy.
Although the prognosis of RMS has improved since several treatments have become available, the management of some types of RMS remains challenging. Cisplatin combined with caffeine chemotherapy should be considered as one treatment option in such cases.

euromagnetic analysis of the late phase of the peadiness field for precise hand movement using magnetoencephalography
Takahashi M; Watanabe Y; Haraguchi T; Kawai T; Yamane G; Abe S; Sakiyama K; Hiraide Y; Won-hyung L; Ide Y; Ishikawa T
Bull Tokyo dent Coll,, 45, 1, 9, 17, Tokyo Dental College, Feb. 2004, [Peer-reviewed]
English, The aim of this study was to elucidate the cortical regulation of precise finger movements by using magnetoencephalography, with particular emphasis on the late phase of the readiness field. Magnetic brain signals were recorded non-invasively by 306 channel magnetoencephalography during the following two tasks. The first task, a simple task, was to bend the right thumb once as quickly as possible. The second task, a precise one, was to alternately oppose the thumb with the index finger and the middle finger of right hand. In this study, we confirmed that the differences between the two tasks were observed in the late phase of the readiness field, especially in the magnetic field 600ms before the onset of movement. The activity of the magnetic field of the precise movement task was higher than the activity of the simple movement task. There were obvious differences in the spatial and temporal aspects of the left hemisphere. In the simple movement, the premotor area or motor area was activated in the late phase of the time window. The average latency from the EMG onset was -98.6±34.0ms (n=5). In the precise movement, the prefrontal area and the SMA were activated in the early and/or middle phases of the time window. The average latency from the EMG onset was -292.0±14.9ms (n=3) for the prefrontal cortex and -167.8±38.3ms (n=4) for the SMA. The premotor area or motor area was activated in the late stage of the RF. The average latency from the EMG onset was -111.6±61.4ms (n=5). Many studies have been performed on the movement-related readiness field. However, the activity of the prefrontal area and the SMA had not previously been studied in the late phase of the readiness field. Our study indicated that the prefrontal area and the SMA played important roles immediately before the onset of precise finger movement. The integration of the prefrontal area, the SMA, and the premotor area is important for the onset of precise finger movement.

Cortical regulation during the early stage of initiation of voluntary swallowing in humans
Yutaka Watanabe; Shinichi Abe; Tatsuya Ishikawa; Yoshiaki Yamada; Gen-Yuki Yamane
Dysphagia, 19, 2, 100, 108, Springer New York, 2004, [Peer-reviewed]
English, Scientific journal

随意嚥下の中枢制御
渡邊裕; 原口孝之; 阿部伸一; 山根源之; 高橋正憲; 石川達也
日本全身咬合学会雑誌, 10, 2, 42, 48, 2004, [Peer-reviewed], [Invited], [Lead author, Corresponding author]

A comparison of oral squamous cell carcinomas between urban and rural areas in Chiba Prefecture
SATO Kazumichi; SASAKI Kenichi; TAMURA Hidetoshi; WATAHIKI Ryuichiro; OGURA Motoi; YAMAZAKI Kayoko; YOSHIDA Kyoko; WATANABE Shinya; OKAZAKI Yuichiro; WATANABE Yutaka; OZAWA Yasuhiro; MORIMOTO Mituaki; TONOGI Morio; YAMANE Gen-yuki
歯科学報, 104, 6, 573, 577, 東京歯科大学学会, 2004, [Peer-reviewed]
Japanese

Case Report : Surgical Treatment of Crouzon Syndrome Compromised with Obstructive Sleep Apnea
TONOGI MORIO; YAMANE GEN-YUKI; WATANABE YUTAKA; SATO KAZUMICHI; TSUKAMOTO YUSUKE; KURIYAMA TOMOHIRO; NAKAJIMA TSUNEYA; MATSUWAKI YOSHINORI; ASAKA DAIYA; SUGA SADAO; WATANABE YOUICHI
Bulletin Of Japanese Society for Jaw Deformities, 14, 2, 137, 144, THE JAPANESE SOCIETY FOR JAW DEFORMITIES, 2004, [Peer-reviewed]
Japanese, We report a patient with Crouzon syndrome and obstructive sleep apnea-hypopnea syndrome (OSAHS) treated by the Rigid External Distraction II System (RED II). The patient was an 18-year-old male. He was previously diagnosed with OSAHS in another hospital and was referred for continuation of treatment of OSAHS after changing his address. In the initial polysomnography (PSG) conducted in our hospital, the apnea-hypopnea index (AHI) was 55.9 events/hour, indicating severe OSAHS. The patient was also diagnosed with Crouzon syndrome based on facial malformation and abnormal form of craniofacial bone. For treatment, we selected bone distraction using the RED II after Le Fort III osteotomy, in order to widen the nasal airway and improve facial malformation and masticatory dysfunction. In this case, the bone distraction procedure was continued for 1 month. The treatment improved physiognomy and occlusion and reduced AHI to 25.9 events/hour after distraction.

Clinical Investigation of Mental Nerve Sensory Testing after SSRO : Second Report on Difference in Recovery Process Influenced by Degree of Sensory Disturbance
TAKASAKI YOSHITO; AKIMOTO YOSHITSUGU; KAKIZAWA TAKASHI; SHIMIZU HIDETAKA; MINAMI KATSUHIRO; MORI YOSHIHIDE; NOGUCHI NOBUHIRO; DANJYO ATSUSHI; GOTO MASA-AKI; HAMASE MAKI; TAKAKI TAKASHI; NOMA HIROYASU; WATANABE YUTAKA; TONOGI MORIO; YAMANE GEN-YUKI
日本顎変形症学会雑誌, 14, 2, 101, 110, 2004, [Peer-reviewed]
Japanese

A case of desmoplastic ameloblastoma in part of a cystic ameloblastoma of the mandible
WATANABE Yutaka; OKAZAKI Yuichiro; HARAGUCHI Takayuki; OZAWA Yasuhiro; YAMANE Gen-yuki; TANAKA Youichi
Journal of Oral Surgery Society of Japan, 50, 8, 479, 482, Japanese Society of Oral and Maxillofacial Surgeons, 2004, [Peer-reviewed], [Lead author, Corresponding author]
Japanese, Desmoplastic ameloblastoma (DA) is classified as a variant of ameloblastoma. DA is a rare lesion and is histologically characterized by extensive stromal collagenization or desmoplasia. We describe our experience with a case of hybrid DA consisting of DA and plexiform ameloblastoma.
The patient was a 52-year-old woman. Swelling was recognized from the mandibular right molar to the right ramus. A multilocular radiolucent area including an impacted tooth was present in the posterior part of the swelling and a radiopaque area with a honeycomb appearance was seen in the anterior part. After the diagnosis of DA, resection of the mandible and reconstruction with an iliac bone graft were performed. Histologically, the anterior lesion showed microscopic features of DA, and the posterior lesion showed those of plexiform ameloblastoma.
We discussed DA and hybrid DA by comparing our case with previously reported cases. We conclude that the diagnosis and treatment of DA require careful consideration.

Magnetoencephalographic study of the starting point of voluntary swallowing
S Abe; Y Wantanabe; M Shintani; M Tazaki; M Takahashi; GY Yamane; Y Ide; Y Yamada; M Shimono; T Ishikawa
CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE, 21, 1, 46, 49, Jan. 2003, [Peer-reviewed]
English, Scientific journal

Experimental device to detect laryngeal movement accompanying swallowing
Abe, S; Kaneko, H; Nakamura, Y; Watanabe, Y; Shintani, M; Hashimoto, M; Yamane, G; Ide, Y; Shimono, M; Ishikawa, T; Yamada, Y; Hayashi, T
Bull. Tokyo dent. Coll.,, 43, 3, 199, 203, Tokyo Dental College, Aug. 2002, [Peer-reviewed]
English, 2003.

Study on Oral Health Care Service for Long-Term Care Insurance System
SUGIHARA Naoki; MAKI Yoshinobu; TAKAESU Yoshinori; WATANABE Yutaka; YAMANE Gen-yuki; ICHINOHE Tatsuya; KANEKO Yuzuru; KIKUCHI Masahiko; WATANABE Makoto; SASAKI Keiichi; SUGA Takeo; MORITO Mitsuhiko; FUKUSHIMA Masayoshi; IWAKU Masaaki; YAMADA Motoko; SATOH Masashi; OSADA Hitoshi
日本歯科医学会誌 = Journal of the Japanese Association for Dental Science : JJDS, 21, 68, 73, 31 Mar. 2002, [Peer-reviewed]
Japanese

多施設共同研究による歯科用アラームシステムの開発
有病者歯科医療
飯田尚紀, 石井宏昭, 関谷秀樹, 瀬戸かん一, 山崎博嗣, 渡邊裕, 山根源之, 龍田恒康, 山本美朗, 松本浩一, 赤坂庸子, 雨宮義弘, 和田知雄, 武田朴, 杉浦啓一, 11, 2, 63, 72, 2002, [Peer-reviewed]

顎関節症を見直す 高齢者と顎関節症
渡邊裕; 佐藤一道; 山根源之
歯科学報, 102, 12, 921, 926, 2002, [Peer-reviewed], [Lead author, Corresponding author]

歯科・口腔外科領域における救急歯性感染症患者の実態
上野正博; 清木洋子; 原口孝之; 森崎重規; 蔵本千夏; 渡邊 裕; 木津康博; 小澤靖弘; 森本光明; 福島大平; 外木守雄; 山根源之
日本外科感染症研究, 14, 83, 87, 2002, [Peer-reviewed]

Evaluation of Oral Appliance (OA) for Obstructive sleep apnea-hypopnea syndrome (OSAHS)
SATO Kazumichi; TSUKAMOTO Yusuke; WATANABE Yutaka; TONOGI Morio; YAMANE Gen-yuki; KuNo Kiyoshi; ASAKA Daiya; MATSUWAKI Yoshinori; NAKAJIMA Tsuneya
歯科学報, 102, 1, 42, 49, 東京歯科大学学会, 2002, [Peer-reviewed]
Japanese

An Effect of Professional Oral Health Care
WATANABE Yutaka
老年歯科医学, 16, 2, 277, 282, 2001, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
Japanese

Clinical Investigation of Mental Nerve Sensory Testing after SSRO : First Report on the Testing Method using the SW Pressure Aesthesiometer
TAKASAKI YOSHITO; NOMA HIROYASU; FUJIKAWA MAKI; TAKAKI TAKASHI; SHIMIZU HIDETAKA; KYOUMOTO HIROYUKI; MORI YOSHIHIDE; NOGUCHI NOBUHIRO; GOTO MASA-AKI; KATSUKI TAKESHI; WATANABE YUTAKA; TONOGI MORIO; YAMANE GEN-YUKI
Jpn J Jaw Deform, 10, 3, 290, 299, 2000, [Peer-reviewed]
Japanese

A tumoral calcinosis-like lesion arising in the maxillary anterior alveolus in a patient undergoing hemodialysis
Yasuhiro OZAWA; Gen-yuki YAMANE; Morio TONOGI; Yutaka WATANABE; Ienaka TAKEDA; Yoichi TANAKA
Jpn. J. Oral Maxillofac. Surg., 46, 8, 484, 486, Japanese Society of Oral and Maxillofacial Surgeons, 2000, [Peer-reviewed]
Japanese, Scientific journal, We describe a tumoral calcinosis-like lesion arising in the maxillary anterior alveolus. The patient was 63-year-old woman who presented with a painless swelling of the maxilla. A benign tumor was suspected, and excision was performed. However, the postoperative histopathological diagnosis was a tumoral calcinosis-like lesion. The patient had been undergoing hemodialysis three times a week for chronic renal failure. Blood chemical analysis revealed that the parathyroid hormone was high (2220pg/ml) and the serum calcium-to-phosphorus product exceeded 70mg/dl before hemodialysis. These results suggested that ectopic calcification had occurred.
To our knowledge, only 2 tumoral calcinosis-like lesions arising in the oral cavity have been reported.

A Case of Follicular Cyst could be Operated after Implantation of DDD Pacemaker for Hypertrophic Obstructive Cardiomy opathy
Katsuhiro Takakur; Gen-yuki Yamane; Ienaka Takeda; Yutaka Watanabe; Morio Tonogi; Yuzuru Kaneko
Japanese Journal of Gerodontology, 14, 2, 111, 117, 1999, [Peer-reviewed]
Japanese

A Clinical Study of Oral Rehabilitation Appliance"PATAKARA^(]J0278[)"
Hirotsugu Yamazaki; Yoshiaki Akihiro; Toru Koyama; Yutaka Watanabe; Morio Tonogi; Gen-yuki Yamane
Japanese Journal of Gerodontology, 14, 2, 106, 110, 1999, [Peer-reviewed]
Japanese

Use of the buccal fat pad as a pedicle graft
SHIBARAHA T, WATANABE Y, YAMAGUCHI S, NOMA H, TAMANE G, ABE S, IDE Y.
The Bolletin of Tokyo dental Collage, 37, 4, 161-197,, 165, 1998, [Peer-reviewed]

A study of the Effect of Semi-Fluid Diet on the Masticatory Muscles of Aged Rats
Yutaka Watanabe; Morio Tonogi; Gen-yuki Yamane; Ikuma Watanabe; Hirohiko Hirano; Naoyoshi Ishiyama; Tetsuhiko Tachikawa
Japanese Journal of Gerodontology, 13, 1, 29, 38, 1998, [Peer-reviewed], [Lead author, Corresponding author]
Japanese

A Study of Factors Affecting the Masticatory Ability of the Elderly
Hirohiko Hirano; Yutaka Watanabe; Naoyoshi Ishiyama; Ikuma Watanabe; Takao Suzuki; Ikuo Nasu
Japanese Journal of Gerodontology, 9, 3, 184, 190, 1995, [Peer-reviewed]
Japanese

Study of the Oral Care of the Elderly((]G0001[)) Analysis of Oral Health Status by Standardized Imaging System
Yutaka Watanabe; Hirohiko Hirano; Naoyoshi Ishiyama; Ikuma Watanabe; Hitomi Yamane; Ikuo Nasu
Japanese Journal of Gerodontolgy, 9, 3, 175, 183, 1995, [Peer-reviewed], [Lead author, Corresponding author]
Japanese

口腔乾燥症患者に対する効果的な唾液腺マッサージ法の検討
大平匡徹; 尾崎公哉; 横山亜矢子; 近藤美弥子; 渡邊裕; 山崎裕, 日本口腔診断学会雑誌, 37, 1, 2024

地域在住高齢者におけるオーラルフレイルと口腔関連QOLの関連
三浦和仁; 尾崎公哉; 横山亜矢子; 奥村拓真; 近藤美弥子; 渡邊裕; 山崎裕, 日本老年歯科医学会学術大会(Web), 35th, 2024

Clinical study in patients with burning mouth syndrome and oral candidiasis
大平匡徹; 三浦和仁; 尾崎公哉; 横山亜矢子; 奥村拓真; 潮田高志; 渡邊裕; 山崎裕, 日本歯科心身医学会雑誌, 39, 1-2, 2024

A case of maxillary anterior tooth defect that underwent esthetic restoration based on a bone grafting (bone augmentation) plan using a full-scale organ model
渡邊裕; 尾崎公哉; 高田篤史, Japanese Journal of Maxillo Facial Implants, 22, 3, 2023

A case of oral dysesthesia is successfully treated with mouthwash over a long period of time
阿部美也子; 新井絵理; 横山亜矢子; 尾崎公哉; 渡邊裕; 山崎裕, 日本歯科心身医学会雑誌, 38, 1-2, 2023

A case of relapse of the fourth burning mouth syndrome due to COVID-19 related stress
稲本香織; 平良賢周; 新井絵里; 尾崎公哉; 渡邊裕; 山崎裕, 日本歯科心身医学会雑誌, 37, 1-2, 2022

サルコペニアは呼吸筋サルコペニアを誘発する
解良 武士; 河合 恒; 平野 浩彦; 小島 基永; 藤原 佳典; 渡邊 裕; 本川 佳子; 井原 一成; 金 憲経; 大渕 修一, 日本呼吸ケア・リハビリテーション学会誌, 29, Suppl., 202s, 202s, Oct. 2019
(一社)日本呼吸ケア・リハビリテーション学会, Japanese

地域在住高齢者における唾液中潜血の変化と口腔機能に関する縦断的研究
松原 ちあき; 白部 麻樹; 濱 芳央子; 五十嵐 憲太郎; 釘宮 嘉浩; 星野 大地; 渡邊 裕; 小原 由紀; 本川 佳子; 本橋 佳子; 枝広 あや子; 古屋 純一; 平野 浩彦; 水口 俊介, 老年歯科医学, 34, 2, 223, 223, Sep. 2019
(一社)日本老年歯科医学会, Japanese

都市在住高齢者の認知機能低下と身体・口腔機能低下との関連
枝広 あや子; 白部 麻樹; 本川 佳子; 松原 ちあき; 釘宮 嘉浩; 五十嵐 憲太郎; 本橋 佳子; 小原 由紀; 平野 浩彦; 渡邊 裕; 粟田 主一, 老年歯科医学, 34, 2, 223, 224, Sep. 2019
(一社)日本老年歯科医学会, Japanese

地域在住高齢者の縦断的な調査によるオーラルフレイルの関連因子の検討
高橋 知佳; 小原 由紀; 白部 麻樹; 本橋 佳子; 枝広 あや子; 本川 佳子; 稲垣 宏樹; 粟田 主一; 平野 浩彦; 渡邊 裕, 日本歯科衛生学会雑誌, 14, 1, 164, 164, Aug. 2019
日本歯科衛生学会, Japanese

通所介護施設の継続に影響する口腔機能および栄養に関する因子の検討
森下 志穂; 小原 由紀; 高橋 知佳; 白部 麻樹; 本橋 佳子; 枝広 あや子; 本川 佳子; 川村 孝子; 平野 浩彦; 渡邊 裕, 日本歯科衛生学会雑誌, 14, 1, 165, 165, Aug. 2019
日本歯科衛生学会, Japanese

地域高齢者における呼吸筋力の評価としての最大呼気流速 呼吸筋サルコペニアの操作的定義についての検討
解良 武士; 河合 恒; 平野 浩彦; 小島 基永; 渡邊 裕; 藤原 佳典; 井原 一成; 大渕 修一, 理学療法学, 46, Suppl.1, O, RS, Aug. 2019
(公社)日本理学療法士協会, Japanese

HbA1cと心身機能との関連について 地域在住高齢者における検討
解良 武士; 河合 恒; 平野 浩彦; 渡邊 裕; 小島 基永; 藤原 佳典; 井原 一成; 大渕 修一, 理学療法学, 46, Suppl.1, O, 3, Aug. 2019
(公社)日本理学療法士協会, Japanese

地域高齢者における足底圧測定装置によって測定した歩行パラメータの基準値
河合 恒; 谷口 優; 大須賀 洋祐; 清野 諭; 渡邊 裕; 金 憲経; 粟田 主一; 新開 省二; 大渕 修一; 高島平Studyグループ, 理学療法学, 46, Suppl.1, P, 13, Aug. 2019
(公社)日本理学療法士協会, Japanese

終末期ケアのための簡易摂食嚥下機能評価の検討
星野 大地; 渡邊 裕; 本川 佳子; 白部 麻樹; 枝広 あや子; 本橋 佳子; 高橋 知佳; 平野 浩彦; 村上 浩史; 弘中 祥司; 丸岡 靖史, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 30回, 優秀P一般, 01, Jun. 2019
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における唾液中潜血の変化と口腔機能に関する縦断的研究
松原 ちあき; 白部 麻樹; 濱 芳央子; 五十嵐 憲太郎; 釘宮 嘉浩; 星野 大地; 渡邊 裕; 小原 由紀; 本川 佳子; 本橋 佳子; 枝広 あや子; 古屋 純一; 平野 浩彦; 水口 俊介, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 30回, P一般, 030, Jun. 2019
(一社)日本老年歯科医学会, Japanese

都市高齢者の認知機能低下と身体・口腔機能低下との関連
枝広 あや子; 本川 佳子; 白部 麻樹; 松原 ちあき; 釘宮 嘉浩; 五十嵐 憲太郎; 本橋 佳子; 小原 由紀; 平野 浩彦; 渡邊 裕; 粟田 主一, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 30回, P一般, 031, Jun. 2019
(一社)日本老年歯科医学会, Japanese

高島平studyにおける会場健診参加者の2年後の追跡 MMSE-J得点の変化
佐久間 尚子; 稲垣 宏樹; 本川 佳子; 渡邊 裕; 枝広 あや子; 宇良 千秋; 小川 まどか; 杉山 美香; 宮前 史子; 岡村 毅; 新開 省二; 粟田 主一, 老年精神医学雑誌, 30, 増刊II, 208, 208, Jun. 2019
(株)ワールドプランニング, Japanese

高島平studyにおける会場健診参加者の2年後の追跡 認知機能低下と社会的孤立との関連
稲垣 宏樹; 佐久間 尚子; 本川 佳子; 渡邊 裕; 枝広 あや子; 宇良 千秋; 小川 まどか; 杉山 美香; 宮前 史子; 岡村 毅; 新開 省二; 粟田 主一, 老年精神医学雑誌, 30, 増刊II, 209, 209, Jun. 2019
(株)ワールドプランニング, Japanese

都市高齢者における孤立の発生に対する社会参加の予防効果 3年間の縦断研究
江尻 愛美; 河合 恒; 藤原 佳典; 井原 一成; 渡邊 裕; 平野 浩彦; 金 憲経; 大渕 修一, 老年社会科学, 41, 2, 200, 200, Jun. 2019
日本老年社会科学会, Japanese

地域在住高齢者における唾液中潜血の変化と口腔機能に関する縦断的研究
松原 ちあき; 白部 麻樹; 濱 芳央子; 五十嵐 憲太郎; 釘宮 嘉浩; 星野 大地; 渡邊 裕; 小原 由紀; 本川 佳子; 本橋 佳子; 枝広 あや子; 古屋 純一; 平野 浩彦; 水口 俊介, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 30回, P一般, 030, Jun. 2019
(一社)日本老年歯科医学会, Japanese

都市高齢者の認知機能低下と身体・口腔機能低下との関連
枝広 あや子; 本川 佳子; 白部 麻樹; 松原 ちあき; 釘宮 嘉浩; 五十嵐 憲太郎; 本橋 佳子; 小原 由紀; 平野 浩彦; 渡邊 裕; 粟田 主一, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 30回, P一般, 031, Jun. 2019
(一社)日本老年歯科医学会, Japanese

地域在住高齢者、通所事業所利用者、介護保険施設入所者の栄養指標の比較
本川 佳子; 白部 麻樹; 枝広 あや子; 田中 弥生; 河合 恒; 解良 武士; 大渕 修一; 平野 浩彦; 渡邊 裕, 日本老年医学会雑誌, 56, Suppl., 174, 175, May 2019
(一社)日本老年医学会, Japanese

独居は認知機能低下のリスクとなるか? ソーシャルネットワークの多寡に着目した検討
藤原 佳典; 桜井 良太; 河合 恒; 金 憲経; 鈴木 宏幸; 小川 将; 渡邊 裕; 平野 浩彦; 井原 一成; 大渕 修一, 日本老年医学会雑誌, 56, Suppl., 87, 87, May 2019
(一社)日本老年医学会, Japanese

スマートフォン内蔵GPSによって測定した日常生活歩行速度とフレイル関連指標との関係
河合 恒; 大渕 修一; 渡邊 裕; 平野 浩彦; 藤原 佳典; 井原 一成; 小林 吉之; 持丸 正明; 対馬 栄輝; 中村 耕三, 日本老年医学会雑誌, 56, Suppl., 118, 118, May 2019
(一社)日本老年医学会, Japanese

アポリポ蛋白E4の保有と歩行速度低下の重積が高齢者の認知機能に与える影響
桜井 良太; 渡邊 裕; 大須賀 洋祐; 谷口 優; 河合 恒; 金 憲経; 北村 明彦; 稲垣 宏樹; 粟田 主一; 新開 省二, 日本老年医学会雑誌, 56, Suppl., 126, 126, May 2019
(一社)日本老年医学会, Japanese

SARC-Fはサルコペニアよりも身体機能の虚弱状態を反映する
解良 武士; 河合 恒; 平野 浩彦; 渡邊 裕; 小島 基永; 藤原 佳典; 井原 一成; 金 憲経; 大渕 修一, 日本老年医学会雑誌, 56, Suppl., 137, 137, May 2019
(一社)日本老年医学会, Japanese

地域在住高齢者、通所事業所利用者、介護保険施設入所者の栄養指標の比較
本川 佳子; 白部 麻樹; 枝広 あや子; 田中 弥生; 河合 恒; 解良 武士; 大渕 修一; 平野 浩彦; 渡邊 裕, 日本老年医学会雑誌, 56, Suppl., 174, 175, May 2019
(一社)日本老年医学会, Japanese

疫学調査における咀嚼能力測定用グミゼリーを用いた視覚スコア法の妥当性の検証
五十嵐 憲太郎; 渡邊 裕; 釘宮 嘉浩; 伊藤 誠康; 金田 恒; 長谷川 陽子; 櫻井 薫; 小野 高裕; 平野 浩彦; 河相 安彦, 日本補綴歯科学会誌, 11, 特別号, 150, 150, May 2019
(公社)日本補綴歯科学会, Japanese

地域在住高齢者の咀嚼能力に関連する口腔関連因子の検討
釘宮 嘉浩; 渡邊 裕; 高野 智史; 上田 貴之; 櫻井 薫, 日本補綴歯科学会誌, 11, 特別号, 313, 313, May 2019
(公社)日本補綴歯科学会, Japanese

基礎から学ぶオーラルフレイル(第3回) オーラルフレイルの評価
渡邊 裕, デンタルハイジーン, 39, 4, 410, 413, Apr. 2019
医歯薬出版(株), Japanese

基礎から学ぶ オーラルフレイル(第2回) オーラルフレイルとは?
渡邊 裕, デンタルハイジーン, 39, 3, 300, 304, Mar. 2019
医歯薬出版(株), Japanese

重度要介護高齢者における簡易な摂食嚥下機能と死亡との関連
星野 大地; 渡邊 裕; 浅井 英之; 大野 かおり; 江並 沙羅; 武内 絵里; 宮久保 あや子; 岡松 良昌; マイヤース 三恵; 丸岡 靖史, 歯科薬物療法, 38, 2, 152, 152, Mar. 2019
(一社)日本歯科薬物療法学会, Japanese

基礎から学ぶ オーラルフレイル(第1回) まずはフレイルを知ろう!
渡邊 裕, デンタルハイジーン, 39, 2, 166, 170, Feb. 2019
医歯薬出版(株), Japanese

【いつまでも食べる楽しみをもち続けるために】 要介護高齢者に対する食支援
渡邊 裕, ふれあいケア, 25, 2, 26, 29, Feb. 2019
(福)全国社会福祉協議会, Japanese

歯科診療所における口腔機能低下への対応-無作為化比較対照試験による検討-
白部麻樹; 白部麻樹; 白部麻樹; 菊谷武; 菊谷武; 佐藤哲郎; 佐藤哲郎; 田中友規; 田中友規; 玉置勝司; 玉置勝司; 戸原玄; 戸原玄; 中條和子; 中條和子; 西本美紗; 西本美紗; 平野浩彦; 平野浩彦; 弘中祥司; 弘中祥司; 山本龍生; 山本龍生; 渡邊裕; 渡邊裕; 石井拓男; 石井拓男; 水口俊介; 水口俊介; 飯島勝矢; 飯島勝矢, 日本老年歯科医学会学術大会(Web), 30th, 2019

神奈川県「口腔ケアによる健康寿命延伸事業」に関する報告
佐藤哲郎; 佐藤哲郎; 菊谷武; 菊谷武; 白部麻樹; 白部麻樹; 田中友規; 田中友規; 玉置勝司; 玉置勝司; 戸原玄; 戸原玄; 中條和子; 中條和子; 西本美紗; 西本美紗; 平野浩彦; 平野浩彦; 弘中祥司; 弘中祥司; 山本龍生; 山本龍生; 渡邊裕; 渡邊裕; 石井拓男; 石井拓男; 飯島勝矢; 飯島勝矢, 日本老年歯科医学会学術大会(Web), 30th, 2019

サルコペニア、呼吸筋サルコペニアおよび口腔/嚥下機能低下と肺炎発生との関連について
解良 武士; 河合 恒; 渡邊 裕; 平野 浩彦; 小島 基永; 藤原 佳典; 井原 一成; 大渕 修一, 日本呼吸ケア・リハビリテーション学会誌, 28, Suppl., 196s, 196s, Oct. 2018
(一社)日本呼吸ケア・リハビリテーション学会, Japanese

高齢者の独居は健康に有害か? ソーシャルネットワークの多寡に着目した検討
桜井 良太; 河合 恒; 金 憲経; 鈴木 宏幸; 小川 将; 渡邊 裕; 平野 浩彦; 井原 一成; 大渕 修一; 藤原 佳典, 日本公衆衛生学会総会抄録集, 77回, 237, 237, Oct. 2018
日本公衆衛生学会, Japanese

タブレット型コンピュータを利用した認知機能検査の開発とその妥当性の検討
高橋 淳太; 河合 恒; 鈴木 宏幸; 藤原 佳典; 渡邊 裕; 平野 浩彦; 金 憲経; 井原 一成; 三木 明子; 大渕 修一, 日本公衆衛生学会総会抄録集, 77回, 273, 273, Oct. 2018
日本公衆衛生学会, Japanese

住民協働の介護予防の推進が地域の健康度や社会関係資本に及ぼす影響
河合 恒; 江尻 愛美; 解良 武士; 渡邊 裕; 藤原 佳典; 平野 浩彦; 小島 基永; 中田 晴美; 大渕 修一, 日本公衆衛生学会総会抄録集, 77回, 409, 409, Oct. 2018
日本公衆衛生学会, Japanese

地域在住高齢者を対象とした縦断調査の追跡の困難さは健康度と関連するか
江尻 愛美; 河合 恒; 渡邊 裕; 平野 浩彦; 藤原 佳典; 井原 一成; 小島 基永; 大渕 修一, 日本公衆衛生学会総会抄録集, 77回, 423, 423, Oct. 2018
日本公衆衛生学会, Japanese

地域づくりによる介護予防のアウトカム措標検討のための予備的研究
植田 拓也; 江尻 愛美; 安永 正史; 河合 恒; 藤原 佳典; 渡邊 裕; 平野 浩彦; 伊藤 久美子; 白部 麻樹; 三木 明子; 大渕 修一, 日本公衆衛生学会総会抄録集, 77回, 431, 431, Oct. 2018
日本公衆衛生学会, Japanese

住民主体の通いの場に参加する地域高齢者の特徴
安永 正史; 江尻 愛美; 植田 拓也; 河合 恒; 伊藤 久美子; 白部 麻樹; 三木 明子; 藤原 佳典; 渡邊 裕; 平野 浩彦; 大渕 修一, 日本公衆衛生学会総会抄録集, 77回, 432, 432, Oct. 2018
日本公衆衛生学会, Japanese

地域在宅高齢者における足底圧分布プラットフォームにより計測した種々の歩行機能と認知機能との関連
谷口 優; 渡邊 裕; 大須賀 洋祐; 北村 明彦; 清野 諭; 金 憲経; 河合 恒; 桜井 良太; 稲垣 宏樹; 粟田 主一; 新開 省二, 日本応用老年学会大会, 13回, 40, 40, Oct. 2018
(一社)日本応用老年学会, Japanese

高齢者の独居は健康に有害か? ソーシャルネットワークの多寡に着目した検討
桜井 良太; 河合 恒; 金 憲経; 鈴木 宏幸; 小川 将; 渡邊 裕; 平野 浩彦; 井原 一成; 大渕 修一; 藤原 佳典, 日本公衆衛生学会総会抄録集, 77回, 237, 237, Oct. 2018
日本公衆衛生学会, Japanese

タブレット型コンピュータを利用した認知機能検査の開発とその妥当性の検討
高橋 淳太; 河合 恒; 鈴木 宏幸; 藤原 佳典; 渡邊 裕; 平野 浩彦; 金 憲経; 井原 一成; 三木 明子; 大渕 修一, 日本公衆衛生学会総会抄録集, 77回, 273, 273, Oct. 2018
日本公衆衛生学会, Japanese

住民協働の介護予防の推進が地域の健康度や社会関係資本に及ぼす影響
河合 恒; 江尻 愛美; 解良 武士; 渡邊 裕; 藤原 佳典; 平野 浩彦; 小島 基永; 中田 晴美; 大渕 修一, 日本公衆衛生学会総会抄録集, 77回, 409, 409, Oct. 2018
日本公衆衛生学会, Japanese

地域づくりによる介護予防のアウトカム措標検討のための予備的研究
植田 拓也; 江尻 愛美; 安永 正史; 河合 恒; 藤原 佳典; 渡邊 裕; 平野 浩彦; 伊藤 久美子; 白部 麻樹; 三木 明子; 大渕 修一, 日本公衆衛生学会総会抄録集, 77回, 431, 431, Oct. 2018
日本公衆衛生学会, Japanese

住民主体の通いの場に参加する地域高齢者の特徴
安永 正史; 江尻 愛美; 植田 拓也; 河合 恒; 伊藤 久美子; 白部 麻樹; 三木 明子; 藤原 佳典; 渡邊 裕; 平野 浩彦; 大渕 修一, 日本公衆衛生学会総会抄録集, 77回, 432, 432, Oct. 2018
日本公衆衛生学会, Japanese

日本老年歯科医学会専門医制度に関する意識調査
松尾 浩一郎; 渡邊 裕; 小正 裕; 片倉 朗; 河相 安彦; 藤井 航; 吉川 峰加; 中川 量晴; 羽村 章; 日本老年歯科医学会認定制度委員会, 老年歯科医学, 33, 2, 175, 176, Sep. 2018
(一社)日本老年歯科医学会, Japanese

大都市部在住高齢者の軽度認知機能低下に関連する口腔機能の検討
釘宮 嘉浩; 渡邊 裕; 本川 佳子; 白部 麻樹; 枝広 あや子; 平野 浩彦; 堀部 耕広; 高野 智史; 上田 貴之; 櫻井 薫, 老年歯科医学, 33, 2, 98, 98, Sep. 2018
(一社)日本老年歯科医学会, Japanese

咬筋体積の簡易測定法の検討とサルコペニアとの関連性
村上 正治; 枝広 あや子; 本川 佳子; 小原 由紀; 白部 麻樹; 田中 友規; 飯島 勝矢; 平野 浩彦; 岩佐 康行; 渡邊 裕, 老年歯科医学, 33, 2, 113, 114, Sep. 2018
(一社)日本老年歯科医学会, Japanese

介護老人福祉施設入所高齢者の摂食嚥下機能の簡易評価と死亡との関係 1年間の縦断調査
星野 大地; 渡邊 裕; 本川 佳子; 白部 麻樹; 枝広 あや子; 本橋 佳子; 高橋 知佳; 平野 浩彦; 村上 浩史; 弘中 祥司; 丸岡 靖史, 老年歯科医学, 33, 2, 117, 118, Sep. 2018
(一社)日本老年歯科医学会, Japanese

口腔機能管理指標としての咬合支持と咀嚼機能との関連 義歯装着時の機能的咬合支持の検討
五十嵐 憲太郎; 渡邊 裕; 釘宮 嘉浩; 梅木 賢人; 本川 佳子; 白部 麻樹; 枝広 あや子; 中島 純子; 伊藤 誠康; 平野 浩彦; 櫻井 薫; 河相 安彦, 老年歯科医学, 33, 2, 122, 122, Sep. 2018
(一社)日本老年歯科医学会, Japanese

終末期要介護高齢者の転帰と口腔状況との関係 特定地域悉皆調査に基づく検討
白部 麻樹; 平野 浩彦; 枝広 あや子; 小原 由紀; 本橋 佳子; 森下 志穂; 本川 佳子; 村上 正治; 大渕 修一; 渡邊 裕, 老年歯科医学, 33, 2, 125, 125, Sep. 2018
(一社)日本老年歯科医学会, Japanese

高齢者の主観的口腔健康評価尺度の開発および信頼性・妥当性の検討
小原 由紀; 白部 麻樹; 高橋 知佳; 本川 佳子; 本橋 佳子; 枝広 あや子; 平野 浩彦; 渡邊 裕; 大渕 修一, 老年歯科医学, 33, 2, 132, 133, Sep. 2018
(一社)日本老年歯科医学会, Japanese

通所介護および通所リハビリテーション施設での新たな食支援モデルの検討
古屋 裕康; 石黒 幸枝; 久保山 裕子; 本川 佳子; 渡邊 裕; 田村 文誉; 菊谷 武, 老年歯科医学, 33, 2, 134, 135, Sep. 2018
(一社)日本老年歯科医学会, Japanese

唾液中潜血を指標とした歯周疾患の重症度に影響する要因の検討
松原 ちあき; 古屋 純一; 尾花 三千代; 白部 麻樹; 高橋 知佳; 枝広 あや子; 本橋 佳子; 本川 佳子; 中島 純子; 平野 浩彦; 渡邊 裕, 老年歯科医学, 33, 2, 136, 137, Sep. 2018
(一社)日本老年歯科医学会, Japanese

地域在住高齢者におけるオーラルフレイルに関連する因子の検討
高橋 知佳; 小原 由紀; 枝広 あや子; 白部 麻樹; 村上 正治; 本橋 佳子; 本川 佳子; 中島 純子; 平野 浩彦; 渡邊 裕, 老年歯科医学, 33, 2, 138, 138, Sep. 2018
(一社)日本老年歯科医学会, Japanese

鳥取県後期高齢者歯科健診受診者の口腔機能低下の実態と関連因子の検討
國竹 洋輔; 遠藤 茂雄; 隅田 秀樹; 足立 融; 渡邊 裕; 金田 恒; 小野 高裕, 老年歯科医学, 33, 2, 141, 142, Sep. 2018
(一社)日本老年歯科医学会, Japanese

介護保険施設利用者における口腔機能向上および栄養改善プログラムに関する質的研究
伊藤 加代子; 枝広 あや子; 渡部 芳彦; 小原 由紀; 本橋 佳子; 森下 志穂; 本川 佳子; 井上 誠; 渡邊 裕; 平野 浩彦, 老年歯科医学, 33, 2, 142, 142, Sep. 2018
(一社)日本老年歯科医学会, Japanese

介護保険施設の経口摂取支援のプロセス評価による多職種連携の発展効果
枝広 あや子; 小原 由紀; 白部 麻樹; 本川 佳子; 本橋 佳子; 伊藤 加代子; 渡部 芳彦; 渡邊 裕; 田中 弥生; 安藤 雄一; 平野 浩彦, 老年歯科医学, 33, 2, 163, 163, Sep. 2018
(一社)日本老年歯科医学会, Japanese

日本老年歯科医学会専門医制度に関する意識調査
松尾 浩一郎; 渡邊 裕; 小正 裕; 片倉 朗; 河相 安彦; 藤井 航; 吉川 峰加; 中川 量晴; 羽村 章; 日本老年歯科医学会認定制度委員会, 老年歯科医学, 33, 2, 175, 176, Sep. 2018
(一社)日本老年歯科医学会, Japanese

地域の介護予防を促進するための東京都介護予防推進支援センターにおける歯科衛生士の役割
白部 麻樹; 植田 拓也; 江尻 愛美; 伊藤 久美子; 安永 正史; 中村 睦美; 三木 明子; 平野 浩彦; 渡邊 裕; 大渕 修一, 日本歯科衛生学会雑誌, 13, 1, 163, 163, Aug. 2018
日本歯科衛生学会, Japanese

【フレイル、サルコペニアについて】 歯科医師からの注意 オーラルフレイルを知っていますか?
渡邊 裕, さかえ: 月刊糖尿病ライフ, 58, 8, 10, 11, Aug. 2018
(公社)日本糖尿病協会, Japanese

オーラルフレイルの発現および身体的・精神的要因との関連性の検討
高橋 知佳; 小原 由紀; 白部 麻樹; 枝広 あや子; 本川 佳子; 本橋 佳子; 平野 浩彦; 渡邊 裕, 日本歯科衛生学会雑誌, 13, 1, 139, 139, Aug. 2018
日本歯科衛生学会, Japanese

地域の介護予防を促進するための東京都介護予防推進支援センターにおける歯科衛生士の役割
白部 麻樹; 植田 拓也; 江尻 愛美; 伊藤 久美子; 安永 正史; 中村 睦美; 三木 明子; 平野 浩彦; 渡邊 裕; 大渕 修一, 日本歯科衛生学会雑誌, 13, 1, 163, 163, Aug. 2018
日本歯科衛生学会, Japanese

【高齢者の口腔機能-オーラルフレイル-】 高齢者の口腔機能およびオーラルフレイルに関する現状と今後の展開
渡邊 裕, Geriatric Medicine, 56, 8, 711, 714, Aug. 2018
(株)ライフ・サイエンス, Japanese

【高齢者の口腔機能-オーラルフレイル-】 臨床に役立つQ&A オーラルフレイル改善プログラムについて教えてください
渡邊 裕, Geriatric Medicine, 56, 8, 773, 776, Aug. 2018
(株)ライフ・サイエンス, Japanese

咬筋体積の簡易測定法の検討とサルコペニアとの関連性
村上 正治; 枝広 あや子; 本川 佳子; 小原 由紀; 白部 麻樹; 田中 友規; 飯島 勝矢; 平野 浩彦; 岩佐 康行; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [O1, 22], Jun. 2018
(一社)日本老年歯科医学会, Japanese

高齢者の主観的口腔健康評価尺度の開発および信頼性・妥当性の検討
小原 由紀; 白部 麻樹; 高橋 知佳; 本川 佳子; 本橋 佳子; 枝広 あや子; 平野 浩彦; 渡邊 裕; 大渕 修一, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [優秀P一般, 1], Jun. 2018
(一社)日本老年歯科医学会, Japanese

唾液中潜血を指標とした歯周疾患の重症度に影響する要因の検討
松原 ちあき; 古屋 純一; 尾花 三千代; 白部 麻樹; 高橋 知佳; 枝広 あや子; 本橋 佳子; 本川 佳子; 中島 純子; 平野 浩彦; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [優秀P衛生, 2], Jun. 2018
(一社)日本老年歯科医学会, Japanese

地域在住高齢者におけるオーラルフレイルに関連する因子の検討
高橋 知佳; 小原 由紀; 白部 麻樹; 枝広 あや子; 村上 正治; 本橋 佳子; 本川 佳子; 中島 純子; 平野 浩彦; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [優秀P衛生, 5], Jun. 2018
(一社)日本老年歯科医学会, Japanese

介護保険施設利用者における口腔機能向上および栄養改善プログラムに関する質的研究
伊藤 加代子; 枝広 あや子; 渡部 芳彦; 小原 由紀; 本橋 佳子; 森下 志穂; 本川 佳子; 井上 誠; 渡邊 裕; 平野 浩彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [P一般, 001], Jun. 2018
(一社)日本老年歯科医学会, Japanese

介護保険施設の経口摂取支援のプロセス評価による多職種連携の発展効果
枝広 あや子; 小原 由紀; 白部 麻樹; 本川 佳子; 本橋 佳子; 伊藤 加代子; 渡部 芳彦; 渡邊 裕; 平野 裕彦; 田中 弥生; 安藤 雄一, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [P一般, 037], Jun. 2018
(一社)日本老年歯科医学会, Japanese

介護老人福祉施設入所高齢者の摂食嚥下機能の簡易評価と死亡との関係 1年間の縦断調査
星野 大地; 渡邊 裕; 本川 佳子; 白部 麻樹; 枝広 あや子; 本橋 佳子; 高橋 知佳; 平野 浩彦; 村上 浩史; 弘中 祥司; 丸岡 靖史, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [O2, 1], Jun. 2018
(一社)日本老年歯科医学会, Japanese

終末期要介護高齢者の転帰と口腔状況との関係 特定地域悉皆調査に基づく検討
白部 麻樹; 平野 浩彦; 枝広 あや子; 小原 由紀; 本橋 佳子; 森下 志穂; 本川 佳子; 村上 正治; 大渕 修一; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [O2, 14], Jun. 2018
(一社)日本老年歯科医学会, Japanese

大都市に暮らす高齢者の認知機能低下と身体・口腔機能低下との関連 高島平スタディ
枝広 あや子; 稲垣 宏樹; 宇良 千秋; 岡村 毅; 小川 まどか; 佐久間 尚子; 杉山 美香; 新川 祐利; 宮前 史子; 鈴木 宏幸; 白部 麻樹; 本川 佳子; 渡邊 裕; 金 憲経; 粟田 主一, 老年精神医学雑誌, 29, 増刊II, 195, 195, Jun. 2018
(株)ワールドプランニング, Japanese

地域高齢者に対する縦断調査における追跡困難度
河合 恒; 鶴田 陽和; 江尻 愛美; 増井 幸恵; 渡邊 裕; 平野 浩彦; 藤原 佳典; 井原 一成; 田中 雅嗣; 大渕 修一, 老年社会科学, 40, 2, 223, 223, Jun. 2018
日本老年社会科学会, Japanese

大都市部在住高齢者の認知機能軽度低下に関連する口腔機能の検討
釘宮 嘉浩; 渡邊 裕; 本川 佳子; 白部 麻樹; 枝広 あや子; 平野 浩彦; 堀部 耕広; 高野 智史; 上田 貴之; 櫻井 薫, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [課題2, 1], Jun. 2018
(一社)日本老年歯科医学会, Japanese

口腔機能管理指標としての咬合支持と咀嚼機能との関連 義歯装着時の機能的咬合支持の検討
五十嵐 憲太郎; 渡邊 裕; 釘宮 嘉浩; 梅木 賢人; 本川 佳子; 白部 麻樹; 枝広 あや子; 中島 純子; 伊藤 誠康; 平野 浩彦; 櫻井 薫; 河相 安彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [O2, 9], Jun. 2018
(一社)日本老年歯科医学会, Japanese

地域高齢者に対する縦断調査における追跡困難度
河合 恒; 鶴田 陽和; 江尻 愛美; 増井 幸恵; 渡邊 裕; 平野 浩彦; 藤原 佳典; 井原 一成; 田中 雅嗣; 大渕 修一, 老年社会科学, 40, 2, 223, 223, Jun. 2018
日本老年社会科学会, Japanese

【摂食嚥下リハビリテーションにおける機能評価】 オーラルフレイル
渡邊 裕, Journal of Clinical Rehabilitation, 27, 7, 714, 717, Jun. 2018
医歯薬出版(株), Japanese

大都市に暮らす高齢者のTrail Making Testの成績(その1) 高島平スタディ A版とB版における遂行状況および遂行時間の分布
鈴木 宏幸; 佐久間 尚子; 稲垣 宏樹; 小川 まどか; 小川 将; 枝広 あや子; 宇良 千秋; 杉山 美香; 宮前 史子; 渡邊 裕; 粟田 主一, 老年精神医学雑誌, 29, 増刊II, 184, 184, Jun. 2018
(株)ワールドプランニング, Japanese

大都市に暮らす高齢者のTrail Making Testの成績(その2) 高島平スタディ 年齢、性別、教育年数とMMSE-J得点との関係
佐久間 尚子; 鈴木 宏幸; 稲垣 宏樹; 小川 まどか; 小川 将; 枝広 あや子; 宇良 千秋; 杉山 美香; 宮前 史子; 渡邊 裕; 粟田 主一, 老年精神医学雑誌, 29, 増刊II, 184, 184, Jun. 2018
(株)ワールドプランニング, Japanese

大都市に暮らす高齢者の認知機能低下と身体・口腔機能低下との関連 高島平スタディ
枝広 あや子; 稲垣 宏樹; 宇良 千秋; 岡村 毅; 小川 まどか; 佐久間 尚子; 杉山 美香; 新川 祐利; 宮前 史子; 鈴木 宏幸; 白部 麻樹; 本川 佳子; 渡邊 裕; 金 憲経; 粟田 主一, 老年精神医学雑誌, 29, 増刊II, 195, 195, Jun. 2018
(株)ワールドプランニング, Japanese

大都市に暮らす高齢者を対象とする生活実態調査の参加状況 高島平スタディ 心身機能との関連について
稲垣 宏樹; 宇良 千秋; 枝広 あや子; 岡村 毅; 小川 まどか; 佐久間 尚子; 杉山 美香; 鈴木 宏幸; 新川 祐利; 宮前 史子; 渡邊 裕; 金 憲経; 粟田 主一, 老年精神医学雑誌, 29, 増刊II, 213, 213, Jun. 2018
(株)ワールドプランニング, Japanese

高齢者の咬断能力と混合能力に関連する口腔の機能の検討
釘宮 嘉浩; 堀部 耕広; 高野 智史; 渡邊 裕; 平野 浩彦; 上田 貴之; 櫻井 薫, 歯科学報, 118, 3, 244, 244, Jun. 2018
東京歯科大学学会, Japanese

気管挿管患者の安全で効果的な口腔ケアの確立-実践ケアガイドの導入と活用- 人工呼吸器関連肺炎予防のための気管挿管患者の口腔ケア実践ガイドの活用、普及に向けて
渡邊 裕, 日本クリティカルケア看護学会学術集会抄録集, 14回, [PD3, 5], Jun. 2018
(一社)日本クリティカルケア看護学会, Japanese

大都市部在住高齢者の認知機能軽度低下に関連する口腔機能の検討
釘宮 嘉浩; 渡邊 裕; 本川 佳子; 白部 麻樹; 枝広 あや子; 平野 浩彦; 堀部 耕広; 高野 智史; 上田 貴之; 櫻井 薫, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [課題2, 1], Jun. 2018
(一社)日本老年歯科医学会, Japanese

咬筋体積の簡易測定法の検討とサルコペニアとの関連性
村上 正治; 枝広 あや子; 本川 佳子; 小原 由紀; 白部 麻樹; 田中 友規; 飯島 勝矢; 平野 浩彦; 岩佐 康行; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [O1, 22], Jun. 2018
(一社)日本老年歯科医学会, Japanese

高齢者の主観的口腔健康評価尺度の開発および信頼性・妥当性の検討
小原 由紀; 白部 麻樹; 高橋 知佳; 本川 佳子; 本橋 佳子; 枝広 あや子; 平野 浩彦; 渡邊 裕; 大渕 修一, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [優秀P一般, 1], Jun. 2018
(一社)日本老年歯科医学会, Japanese

通所介護および通所リハビリテーション施設での新たな食支援モデルの検討
古屋 裕康; 石黒 幸枝; 久保山 裕子; 本川 佳子; 渡邊 裕; 田村 文誉; 菊谷 武, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [優秀P一般, 4], Jun. 2018
(一社)日本老年歯科医学会, Japanese

唾液中潜血を指標とした歯周疾患の重症度に影響する要因の検討
松原 ちあき; 古屋 純一; 尾花 三千代; 白部 麻樹; 高橋 知佳; 枝広 あや子; 本橋 佳子; 本川 佳子; 中島 純子; 平野 浩彦; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [優秀P衛生, 2], Jun. 2018
(一社)日本老年歯科医学会, Japanese

地域在住高齢者におけるオーラルフレイルに関連する因子の検討
高橋 知佳; 小原 由紀; 白部 麻樹; 枝広 あや子; 村上 正治; 本橋 佳子; 本川 佳子; 中島 純子; 平野 浩彦; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [優秀P衛生, 5], Jun. 2018
(一社)日本老年歯科医学会, Japanese

鳥取県後期高齢者歯科健診受診者の口腔機能低下の実態と関連因子の検討
國竹 洋輔; 遠藤 茂雄; 隅田 秀樹; 足立 融; 渡邊 裕; 金田 恒; 小野 高裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [優秀P地域, 5], Jun. 2018
(一社)日本老年歯科医学会, Japanese

介護保険施設利用者における口腔機能向上および栄養改善プログラムに関する質的研究
伊藤 加代子; 枝広 あや子; 渡部 芳彦; 小原 由紀; 本橋 佳子; 森下 志穂; 本川 佳子; 井上 誠; 渡邊 裕; 平野 浩彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [P一般, 001], Jun. 2018
(一社)日本老年歯科医学会, Japanese

介護保険施設の経口摂取支援のプロセス評価による多職種連携の発展効果
枝広 あや子; 小原 由紀; 白部 麻樹; 本川 佳子; 本橋 佳子; 伊藤 加代子; 渡部 芳彦; 渡邊 裕; 平野 裕彦; 田中 弥生; 安藤 雄一, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [P一般, 037], Jun. 2018
(一社)日本老年歯科医学会, Japanese

日本老年歯科医学会専門医制度に関する意識調査
松尾 浩一郎; 渡邊 裕; 小正 裕; 片倉 朗; 河相 安彦; 藤井 航; 吉川 峰加; 中川 量晴; 羽村 章; 日本老年歯科医学会認定制度委員会, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [P一般, 059], Jun. 2018
(一社)日本老年歯科医学会, Japanese

地域連携Nutrition Support Teamで対応した高齢摂食嚥下障害患者の1例
渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [摂食P, 13], Jun. 2018
(一社)日本老年歯科医学会, Japanese

介護老人福祉施設入所高齢者の摂食嚥下機能の簡易評価と死亡との関係 1年間の縦断調査
星野 大地; 渡邊 裕; 本川 佳子; 白部 麻樹; 枝広 あや子; 本橋 佳子; 高橋 知佳; 平野 浩彦; 村上 浩史; 弘中 祥司; 丸岡 靖史, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [O2, 1], Jun. 2018
(一社)日本老年歯科医学会, Japanese

口腔機能管理指標としての咬合支持と咀嚼機能との関連 義歯装着時の機能的咬合支持の検討
五十嵐 憲太郎; 渡邊 裕; 釘宮 嘉浩; 梅木 賢人; 本川 佳子; 白部 麻樹; 枝広 あや子; 中島 純子; 伊藤 誠康; 平野 浩彦; 櫻井 薫; 河相 安彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [O2, 9], Jun. 2018
(一社)日本老年歯科医学会, Japanese

終末期要介護高齢者の転帰と口腔状況との関係 特定地域悉皆調査に基づく検討
白部 麻樹; 平野 浩彦; 枝広 あや子; 小原 由紀; 本橋 佳子; 森下 志穂; 本川 佳子; 村上 正治; 大渕 修一; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 29回, [O2, 14], Jun. 2018
(一社)日本老年歯科医学会, Japanese

大都市部在住高齢者における認知的フレイルの特徴と関連要因
金 憲経; 粟田 主一; 渡邊 裕; 小島 成実; 大須賀 洋祐; 本川 佳子; 稲垣 宏樹; 佐久間 尚子; 枝広 あや子; 新開 省二, 日本老年医学会雑誌, 55, Suppl., 118, 119, May 2018
(一社)日本老年医学会, Japanese

地域在住高齢者における高次生活機能の低下とフレイル、プレフレイルの関連
江尻 愛美; 河合 恒; 藤原 佳典; 平野 浩彦; 井原 一成; 小島 基永; 渡邊 裕; 大渕 修一, 日本老年医学会雑誌, 55, Suppl., 119, 119, May 2018
(一社)日本老年医学会, Japanese

地域高齢者におけるMoCA-Jの反復効果 6年の縦断追跡による検討
鈴木 宏幸; 河合 恒; 小川 将; 桜井 良太; 平野 浩彦; 金 憲経; 井原 一成; 渡邊 裕; 大渕 修一; 藤原 佳典, 日本老年医学会雑誌, 55, Suppl., 164, 164, May 2018
(一社)日本老年医学会, Japanese

【トータルケアをめざしたフレイル診療】 《フレイルをより深く知るためのエッセンス》 オーラルフレイルとは
渡邊 裕, Modern Physician, 38, 5, 454, 458, May 2018
(株)新興医学出版社, Japanese

オーラルフレイルを理解する オーラルフレイルの疫学
渡邊 裕, 日本抗加齢医学会総会プログラム・抄録集, 18回, 150, 150, May 2018
(一社)日本抗加齢医学会, Japanese

オーラルフレイル簡易スクリーニング法の開発 マルチ観察データによる外的妥当性検証
田中 友規; 平野 浩彦; 渡邊 裕; 菊谷 武; 中條 和子; 佐藤 哲郎; 鈴木 駿介; 秋下 雅弘; 飯島 勝矢, 日本老年医学会雑誌, 55, Suppl., 113, 113, May 2018
(一社)日本老年医学会, Japanese

大都市部在住高齢者における認知的フレイルの特徴と関連要因
金 憲経; 粟田 主一; 渡邊 裕; 小島 成実; 大須賀 洋祐; 本川 佳子; 稲垣 宏樹; 佐久間 尚子; 枝広 あや子; 新開 省二, 日本老年医学会雑誌, 55, Suppl., 118, 119, May 2018
(一社)日本老年医学会, Japanese

地域在住高齢者における高次生活機能の低下とフレイル、プレフレイルの関連
江尻 愛美; 河合 恒; 藤原 佳典; 平野 浩彦; 井原 一成; 小島 基永; 渡邊 裕; 大渕 修一, 日本老年医学会雑誌, 55, Suppl., 119, 119, May 2018
(一社)日本老年医学会, Japanese

地域高齢者におけるMoCA-Jの反復効果 6年の縦断追跡による検討
鈴木 宏幸; 河合 恒; 小川 将; 桜井 良太; 平野 浩彦; 金 憲経; 井原 一成; 渡邊 裕; 大渕 修一; 藤原 佳典, 日本老年医学会雑誌, 55, Suppl., 164, 164, May 2018
(一社)日本老年医学会, Japanese

【高齢者のフレイル(虚弱)と生活機能低下】 高齢者の口腔機能の低下とフレイル
渡邊 裕, 地域リハビリテーション, 13, 3, 187, 192, Mar. 2018
(株)三輪書店, Japanese

オーラルフレイルへの対策を考える
渡邊 裕, 全国大学歯科衛生士教育協議会雑誌, 7, 9, 12, Mar. 2018
全国大学歯科衛生士教育協議会編集委員会, Japanese

オーラルフレイル最前線・神奈川県における取り組み 神奈川県口腔ケアによる健康寿命延伸事業オーラルフレイル改善プログラム介入調査について
渡邊 裕, 社会歯科学会雑誌, 10, 2, 18, 21, Mar. 2018
社会歯科学会, Japanese

歯周病はオーラルフレイルのリスクを高める-地域在住高齢者コホート研究:柏スタディより-
西本美紗; 田中友規; 田中友規; 平野浩彦; 菊谷武; 渡邊裕; 小原由紀; 古屋裕康; 飯島勝矢, 日本サルコペニア・フレイル学会誌, 2018

サルコペニア・フレイルの評価とリハビリテーション栄養 地域在住高齢者のフレイル重症度と栄養関連指標の検討
本川 佳子; 枝広 あや子; 平野 浩彦; 田中 弥生; 渡邊 裕, 日本静脈経腸栄養学会雑誌, 33, Suppl., 260, 260, Jan. 2018
(株)ジェフコーポレーション, Japanese

特別養護老人ホーム入所要介護高齢者の食欲と死亡との関係 1年間の縦断調査
渡邊 裕; 本川 佳子; 枝広 あや子; 平野 浩彦; 田中 弥生, 日本静脈経腸栄養学会雑誌, 33, Suppl., 466, 466, Jan. 2018
(株)ジェフコーポレーション, Japanese

【周術期のオーラルマネジメント】 (Part 1)周術期における医科歯科連携と看護師の役割
渡邊 裕, 看護技術, 63, 14, 1372, 1375, Dec. 2017
(株)メヂカルフレンド社, Japanese

咬合機能回復からフレイルの予防・脱却を目指す健康増進支援システムの構築 日本補綴歯科学会と神奈川県歯科医師会の取り組みからの考察
玉置 勝司; 佐藤 哲郎; 中條 和子; 新開 省二; 渡邊 裕; 平野 浩彦, 神奈川歯学, 52, 抄録集, 42, 42, Nov. 2017
神奈川歯科大学学会, Japanese

咬合機能回復からフレイルの予防・脱却を目指す健康増進支援システムの構築 オーラル・フレイルとシステムの概要について
玉置 勝司; 平野 浩彦; 渡邊 裕; 新開 省二; 飯島 勝矢; 松永 善充, 神奈川歯学, 52, 抄録集, 60, 60, Nov. 2017
神奈川歯科大学学会, Japanese

超高齢社会を生き抜く歯周病予防・治療の考え方 フレイル、オーラルフレイルの疫学
渡邊 裕, 日本歯周病学会会誌, 59, 秋季特別, 138, 138, Nov. 2017
(NPO)日本歯周病学会, Japanese

認知症グループホーム入居高齢者における認知症重症度と栄養状態の関連
本川 佳子; 田中 弥生; 菅 洋子; 細山田 洋子; 枝広 あや子; 平野 浩彦; 渡邊 裕, 日本在宅栄養管理学会誌, 4, 2, 135, 141, Oct. 2017
認知症対応型共同生活介護施設(グループホーム)に入居する高齢者の認知症重症度と栄養状態の関連を明らかにすることを目的に、K県Y市内のグループホームに入居する高齢者でアルツハイマー病と診断されている123名(女性103名、男性20名、平均年齢84.9±6.7歳)を対象に、CDR(Clinical Dementia Rating)を用いた認知症重症度の評価、低栄養の判定、食品摂取多様性、食欲などの調査を行った。その結果、CDR3(高度認知症)群(11名)において27.3%の高率で低栄養が確認された。また、食欲の評価法であるCNAQ(Council on Nutrition Appetite Questionnaire)スコアで、CDR3群はCDR0.5群(認知症の疑い。16名)に比べ、有意に低値を示しており、認知症の重症度と食欲の減退に有意な相関が認められた。, (一社)日本在宅栄養管理学会, Japanese

いまなぜオーラルフレイルが重要なのか オーラルフレイルと食事・栄養の関わり
本川 佳子; 枝広 あや子; 白部 麻樹; 井原 一成; 田中 弥生; 金 憲経; 藤原 佳典; 大渕 修一; 河合 恒; 平野 浩彦; 渡邊 裕, 日本サルコペニア・フレイル学会雑誌, 1, 2, 96, 96, Oct. 2017
(一社)日本サルコペニア・フレイル学会, Japanese

いまなぜオーラルフレイルが重要なのか オーラルフレイルと認知機能、抑うつ傾向の関連
枝広 あや子; 本川 佳子; 白部 麻樹; 小原 由紀; 杉山 美香; 稲垣 宏樹; 宇良 千秋; 宮前 史子; 岡村 毅; 村山 洋史; 大渕 修一; 藤原 佳典; 金 憲経; 井原 一成; 河合 恒; 渡邊 裕; 平野 浩彦; 粟田 主一, 日本サルコペニア・フレイル学会雑誌, 1, 2, 96, 96, Oct. 2017
(一社)日本サルコペニア・フレイル学会, Japanese

高齢者の自転車運転時の転倒に関連する要因 横断および縦断的検討
桜井 良太; 河合 恒; 金 憲経; 鈴木 宏幸; 小川 将; 渡邊 裕; 平野 浩彦; 井原 一成; 大渕 修一; 藤原 佳典, 日本公衆衛生学会総会抄録集, 76回, 308, 308, Oct. 2017
日本公衆衛生学会, Japanese

高島平Study 大都市部認知症高齢者の生活実態調査の方法と課題に関する検討
稲垣 宏樹; 粟田 主一; 佐久間 尚子; 金 憲経; 枝広 あや子; 杉山 美香; 白部 麻樹; 本川 佳子; 宇良 千秋; 小川 まどか; 宮前 史子; 渡邊 裕; 新開 省二, 日本公衆衛生学会総会抄録集, 76回, 397, 397, Oct. 2017
日本公衆衛生学会, Japanese

高島平Study 大都市部在住高齢者の会場調査と訪問調査のMMSE-J得点
佐久間 尚子; 稲垣 宏樹; 小川 まどか; 枝広 あや子; 宇良 千秋; 杉山 美香; 宮前 史子; 鈴木 宏幸; 渡邊 裕; 粟田 主一, 日本公衆衛生学会総会抄録集, 76回, 397, 397, Oct. 2017
日本公衆衛生学会, Japanese

高島平study 大都市部在住高齢者における重複フレイルの特徴と関連要因
金 憲経; 粟田 主一; 渡邊 裕; 小島 成実; 藤野 健; 大須賀 洋祐; 本川 佳子; 佐久間 尚子; 稲垣 宏樹; 杉山 美香; 小川 まどか; 枝広 あや子; 新開 省二, 日本公衆衛生学会総会抄録集, 76回, 398, 398, Oct. 2017
日本公衆衛生学会, Japanese

高島平Study 大都市在住高齢者の食欲低下に関連する要因の検討
枝広 あや子; 杉山 美香; 稲垣 宏樹; 小川 まどか; 宇良 千秋; 佐久間 尚子; 宮前 史子; 本川 佳子; 本橋 佳子; 渡邊 裕; 岡村 毅; 金 憲経; 新開 省二; 粟田 主一, 日本公衆衛生学会総会抄録集, 76回, 398, 398, Oct. 2017
日本公衆衛生学会, Japanese

高島平Study 認知機能低下がみられる地域在住高齢者の生活支援ニーズ
杉山 美香; 宮前 史子; 佐久間 尚子; 稲垣 宏樹; 宇良 千秋; 小川 まどか; 枝広 あや子; 本川 佳子; 岡村 毅; 渡邊 裕; 金 憲経; 新開 省二; 粟田 主一, 日本公衆衛生学会総会抄録集, 76回, 398, 398, Oct. 2017
日本公衆衛生学会, Japanese

高島平Study 大都市在住高齢者における認知機能と栄養指標との関連
本川 佳子; 渡邊 裕; 平野 浩彦; 枝広 あや子; 本橋 佳子; 白部 麻樹; 三上 友里江; 大須賀 洋祐; 佐久間 尚子; 宇良 千秋; 稲垣 宏樹; 小川 まどか; 金 憲経; 新開 省二; 粟田 主一, 日本公衆衛生学会総会抄録集, 76回, 398, 398, Oct. 2017
日本公衆衛生学会, Japanese

高島平Study 大都市部在住高齢者における口腔への関心に関連する因子の検討
本橋 佳子; 渡邊 裕; 本川 佳子; 枝広 あや子; 白部 麻樹; 三上 友里江; 大須賀 洋祐; 平野 浩彦; 金 憲経; 北村 明彦; 藤原 佳典; 大渕 修一; 石崎 達郎; 新開 省二; 粟田 主一, 日本公衆衛生学会総会抄録集, 76回, 399, 399, Oct. 2017
日本公衆衛生学会, Japanese

高島平Study 都市部在住高齢者の外出頻度の減少と口腔機能低下との関連
三上 友里江; 渡邊 裕; 本川 佳子; 枝広 あや子; 白部 麻樹; 本橋 佳子; 大須賀 洋祐; 平野 浩彦; 金 憲経; 北村 明彦; 藤原 佳典; 大渕 修一; 石崎 達郎; 新開 省二; 粟田 主一, 日本公衆衛生学会総会抄録集, 76回, 399, 399, Oct. 2017
日本公衆衛生学会, Japanese

高島平Study 大都市部在住高齢者のかかりつけ歯科医院への受診と口腔・栄養との関連
白部 麻樹; 渡邊 裕; 本川 佳子; 本橋 佳子; 三上 友里江; 大須賀 洋祐; 枝広 あや子; 平野 浩彦; 小川 まどか; 稲垣 宏樹; 河合 恒; 大渕 修一; 金 憲経; 粟田 主一; 新開 省二, 日本公衆衛生学会総会抄録集, 76回, 399, 399, Oct. 2017
日本公衆衛生学会, Japanese

認知症高齢者に対する口腔管理と経口摂取支援に関するGL作成の試み 予備文献検索
本橋 佳子; 平野 浩彦; 櫻井 孝; 櫻井 薫; 市川 哲雄; 高野 直久; 深井 穫博; 武井 典子; 大塚 礼; 山田 律子; 田中 弥生; 野原 幹司; 渡邊 裕; 枝広 あや子, 老年歯科医学, 32, 2, 256, 257, Sep. 2017
(一社)日本老年歯科医学会, Japanese

介護老人保健施設退所後の在宅療養継続に影響する因子の検討
森下 志穂; 渡邊 裕; 平野 浩彦; 枝広 あや子; 本川 佳子; 白部 麻樹; 村上 正治; 糸田 昌隆, 老年歯科医学, 32, 2, 115, 116, Sep. 2017
(一社)日本老年歯科医学会, Japanese

Frailtyへの移行に咀嚼機能の低下が及ぼす影響
堀部 耕広; 渡邊 裕; 平野 浩彦; 枝広 あや子; 本川 佳子; 白部 麻樹; 大渕 修一; 大神 浩一郎; 上田 貴之; 櫻井 薫, 老年歯科医学, 32, 2, 149, 149, Sep. 2017
(一社)日本老年歯科医学会, Japanese

アルツハイマー型認知症(AD)とレビー小体型認知症(DLB)の食行動特性の比較検討
須磨 紫乃; 渡邊 裕; 平野 浩彦; 枝広 あや子; 白部 麻樹; 本川 佳子; 木村 藍; 松下 健二; 荒井 秀典; 櫻井 孝, 老年歯科医学, 32, 2, 150, 151, Sep. 2017
(一社)日本老年歯科医学会, Japanese

地域在住高齢者の唾液中潜血に関連する因子の検討
松原 ちあき; 白部 麻樹; 渡邊 裕; 尾花 三千代; 本川 佳子; 村上 正治; 枝広 あや子; 平野 浩彦; 古屋 純一, 老年歯科医学, 32, 2, 152, 153, Sep. 2017
(一社)日本老年歯科医学会, Japanese

アルツハイマー型認知症高齢者の嚥下機能低下に関連する予知因子の検討
白部 麻樹; 平野 浩彦; 枝広 あや子; 小原 由紀; 森下 志穂; 本川 佳子; 村上 正治; 村上 浩史; 高城 大輔; 渡邊 裕, 老年歯科医学, 32, 2, 153, 154, Sep. 2017
(一社)日本老年歯科医学会, Japanese

都市部在住高齢者の咀嚼機能および食品摂取の多様性の低下と認知機能との関係
釘宮 嘉浩; 渡邊 裕; 平野 浩彦; 枝広 あや子; 本川 佳子; 堀部 耕広; 小野 高裕; 上田 貴之; 櫻井 薫, 老年歯科医学, 32, 2, 161, 162, Sep. 2017
(一社)日本老年歯科医学会, Japanese

都市部在住高齢者のフレイルと口腔機能低下との関連に関する検討
五十嵐 憲太郎; 渡邊 裕; 平野 浩彦; 枝広 あや子; 本川 佳子; 梅木 賢人; 伊藤 誠康; 河相 安彦; 小野 高裕, 老年歯科医学, 32, 2, 162, 163, Sep. 2017
(一社)日本老年歯科医学会, Japanese

通所施設における栄養改善および口腔機能向上サービスの実施体制に関する調査
永島 圭悟; 古屋 裕康; 渡邊 裕; 大島 克郎; 田村 文誉; 菊谷 武, 老年歯科医学, 32, 2, 198, 199, Sep. 2017
(一社)日本老年歯科医学会, Japanese

通所介護施設での口腔機能低下及び低栄養に対する食支援モデルの検討
古屋 裕康; 永島 圭悟; 岩渕 信; 石黒 幸枝; 久保山 裕子; 渡邊 裕; 大島 克郎; 田村 文誉; 菊谷 武, 老年歯科医学, 32, 2, 236, 236, Sep. 2017
(一社)日本老年歯科医学会, Japanese

認知症高齢者に対する口腔管理と経口摂取支援に関するGL作成の試み 予備文献検索
本橋 佳子; 平野 浩彦; 櫻井 孝; 櫻井 薫; 市川 哲雄; 高野 直久; 深井 穫博; 武井 典子; 大塚 礼; 山田 律子; 田中 弥生; 野原 幹司; 渡邊 裕; 枝広 あや子, 老年歯科医学, 32, 2, 256, 257, Sep. 2017
(一社)日本老年歯科医学会, Japanese

論文を書くために押さえておくべきポイントについて 読者目線のやさしい論文作成法
渡邊 裕, 障害者歯科, 38, 3, 243, 243, Sep. 2017
(一社)日本障害者歯科学会, Japanese

通所介護事業所利用者に対する口腔機能向上および栄養改善の複合サービスの長期介入効果
森下 志穂; 渡邊 裕; 平野 浩彦; 枝広 あや子; 小原 由紀; 白部 麻樹; 後藤 百合; 柴田 雅子; 長尾 志保; 三角 洋美, 日本歯科衛生学会雑誌, 12, 1, 36, 46, Aug. 2017
日本歯科衛生学会, Japanese

地域在住高齢者における咀嚼能力指標に関する実態調査
白部 麻樹; 小原 由紀; 渡邊 裕; 平野 浩彦; 枝広 あや子; 村上 正治; 本川 佳子; 河合 恒; 大渕 修一, 日本歯科衛生学会雑誌, 12, 1, 103, 103, Aug. 2017
日本歯科衛生学会, Japanese

地域在住高齢者における歯科保健指導経験の有無に関連する因子の検討
小原 由紀; 渡邊 裕; 平野 浩彦; 白部 麻樹; 枝広 あや子; 本川 佳子; 河合 恒; 藤原 佳典; 大渕 修一; 遠藤 圭子, 日本歯科衛生学会雑誌, 12, 1, 133, 133, Aug. 2017
日本歯科衛生学会, Japanese

顔面および口腔内の過敏症状を有する要介護高齢者の口腔機能および栄養状態に関する実態調査
白部 麻樹; 中山 玲奈; 平野 浩彦; 小原 由紀; 遠藤 圭子; 渡邊 裕; 白田 千代子, 日本公衆衛生雑誌, 64, 7, 351, 358, Jul. 2017
日本公衆衛生学会, Japanese

認知症高齢者に対する口腔管理と経口摂取支援に関するGL作成の試み 予備文献検索
本橋 佳子; 平野 浩彦; 櫻井 孝; 櫻井 薫; 市川 哲雄; 高野 直久; 深井 穫博; 武井 典子; 大塚 礼; 山田 律子; 田中 弥生; 野原 幹司; 渡邊 裕; 枝広 あや子, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 227, 227, Jun. 2017
(一社)日本老年歯科医学会, Japanese

当事者主体の地域包括ケアを目指して コーディネーターのかかわりによって私的社会統制を強めない住民協働の介護予防の推進効果
河合 恒; 大渕 修一; 藤原 佳典; 平野 浩彦; 渡邊 裕; 荒木 厚; 小山 照幸; 杉江 正光; 小島 基永; 中田 晴美; 鈴木 隆雄, 老年社会科学, 39, 2, 154, 154, Jun. 2017
日本老年社会科学会, Japanese

健康日本21(第2次)の視点からみた介護予防の推進 新しい総合事業における口腔機能向上及び栄養改善の推進に資する地域医療介護連携の取組
福泉 隆喜; 山口 摂崇; 植田 耕一郎; 菊谷 武; 平野 浩彦; 渡邊 裕; 小坂 健; 藤井 航; 北原 稔; 仲山 智恵; 早淵 仁美; 飯島 勝矢; 介護予防; 日常生活支援総合事業における口腔機能; 栄養; 運動複合型プログラムを用いた住民参加型介護予防活動に関する調査研究; 研究班, 老年社会科学, 39, 2, 162, 162, Jun. 2017
日本老年社会科学会, Japanese

特別養護老人ホーム入所者における自発摂食評価と死亡率との関係 30ヵ月間のコホート研究
坂本 まゆみ; 渡邊 裕; 葭原 明弘, 新潟歯学会雑誌, 47, 1, 52, 53, Jun. 2017
新潟歯学会, Japanese

要介護高齢者における自発摂食力評価と入院・死亡との関連
本川 佳子; 枝広 あや子; 白部 麻樹; 田中 弥生; 平野 浩彦; 渡邊 裕, 日本在宅栄養管理学会誌, 4, 1, 69, 69, Jun. 2017
(一社)日本在宅栄養管理学会, Japanese

フレイル研究の現状及び展望 オーラルフレイル研究の現状および展望
渡邊 裕; 本川 佳子; 白部 麻樹; 村上 正治; 枝広 あや子; 平野 浩彦, 基礎老化研究, 41, Suppl., 100, 100, Jun. 2017
日本基礎老化学会, Japanese

会場健診に参加する都市部在住高齢者のMMSE-Jの得点分布 速報版
佐久間 尚子; 稲垣 宏樹; 小川 まどか; 鈴木 宏幸; 枝広 あや子; 宇良 千秋; 杉山 美香; 宮前 史子; 渡邊 裕; 粟田 主一, 老年精神医学雑誌, 28, 増刊II, 216, 216, Jun. 2017
(株)ワールドプランニング, Japanese

介護老人保健施設退所後の在宅療養継続に影響する因子の検討
森下 志穂; 渡邊 裕; 平野 浩彦; 枝広 あや子; 本川 佳子; 白部 麻樹; 村上 正治; 糸田 昌隆, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 114, 114, Jun. 2017
(一社)日本老年歯科医学会, Japanese

Frailtyへの移行に咀嚼機能の低下が及ぼす影響
堀部 耕広; 渡邊 裕; 平野 浩彦; 枝広 あや子; 本川 佳子; 白部 麻樹; 大渕 修一; 大神 浩一郎; 上田 貴之; 櫻井 薫, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 145, 145, Jun. 2017
(一社)日本老年歯科医学会, Japanese

アルツハイマー型認知症(AD)とレビー小体型認知症(DLB)の食行動特性の比較検討
須磨 紫乃; 渡邊 裕; 平野 浩彦; 枝広 あや子; 白部 麻樹; 本川 佳子; 木村 藍; 松下 健二; 荒井 秀典; 櫻井 孝, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 146, 146, Jun. 2017
(一社)日本老年歯科医学会, Japanese

地域在住高齢者の唾液中潜血に関連する因子の検討
松原 ちあき; 白部 麻樹; 渡邊 裕; 尾花 三千代; 本川 佳子; 村上 正治; 枝広 あや子; 平野 浩彦; 古屋 純一, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 150, 150, Jun. 2017
(一社)日本老年歯科医学会, Japanese

アルツハイマー型認知症高齢者の嚥下機能低下に関連する予知因子の検討
白部 麻樹; 平野 浩彦; 枝広 あや子; 小原 由紀; 森下 志穂; 本川 佳子; 村上 正治; 村上 浩史; 高城 大輔; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 150, 150, Jun. 2017
(一社)日本老年歯科医学会, Japanese

都市部在住高齢者の咀嚼機能および食品摂取の多様性の低下と認知機能との関係
釘宮 嘉浩; 渡邊 裕; 平野 浩彦; 本川 佳子; 堀部 耕広; 小野 高裕; 上田 貴之; 櫻井 薫, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 156, 156, Jun. 2017
(一社)日本老年歯科医学会, Japanese

都市部在住高齢者のフレイルと口腔機能低下との関連に関する検討
五十嵐 憲太郎; 渡邊 裕; 平野 浩彦; 枝広 あや子; 梅木 賢人; 伊藤 誠康; 河相 安彦; 小野 高裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 157, 157, Jun. 2017
(一社)日本老年歯科医学会, Japanese

通所施設における栄養改善および口腔機能向上サービスの実施体制に関する調査
永島 圭悟; 古屋 裕康; 渡邊 裕; 大島 克郎; 田村 文誉; 菊谷 武, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 186, 186, Jun. 2017
(一社)日本老年歯科医学会, Japanese

通所介護施設での口腔機能低下及び低栄養に対する食支援モデルの検討
古屋 裕康; 永島 圭悟; 岩渕 信; 石黒 幸枝; 久保山 裕子; 渡邊 裕; 大島 克郎; 田村 文誉; 菊谷 武, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 212, 212, Jun. 2017
(一社)日本老年歯科医学会, Japanese

認知症高齢者に対する口腔管理と経口摂取支援に関するGL作成の試み 予備文献検索
本橋 佳子; 平野 浩彦; 櫻井 孝; 櫻井 薫; 市川 哲雄; 高野 直久; 深井 穫博; 武井 典子; 大塚 礼; 山田 律子; 田中 弥生; 野原 幹司; 渡邊 裕; 枝広 あや子, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 227, 227, Jun. 2017
(一社)日本老年歯科医学会, Japanese

認知症の人と家族を支える医療とケア 認知症の方の美味しく安全な食への支援
枝広 あや子; 平野 浩彦; 本川 佳子; 白部 麻樹; 村上 正治; 渡邊 裕, 日本老年医学会雑誌, 54, Suppl., 9, 9, May 2017
(一社)日本老年医学会, Japanese

フレイル研究の現状及び展望 オーラルフレイル研究の現状および展望
渡邊 裕; 本川 佳子; 白部 麻樹; 村上 正治; 枝広 あや子; 平野 浩彦, 日本老年医学会雑誌, 54, Suppl., 10, 10, May 2017
(一社)日本老年医学会, Japanese

当事者主体の地域包括ケアを目指して コーディネーターのかかわりによって私的社会統制を強めない住民協働の介護予防の推進効果
河合 恒; 大渕 修一; 藤原 佳典; 平野 浩彦; 渡邊 裕; 荒木 厚; 小山 照幸; 杉江 正光; 小島 基永; 中田 晴美; 鈴木 隆雄, 日本老年医学会雑誌, 54, Suppl., 27, 27, May 2017
(一社)日本老年医学会, Japanese

健康日本21(第2次)の視点からみた介護予防の推進 新しい総合事業における口腔機能向上及び栄養改善の推進に資する地域医療介護連携の取組
福泉 隆喜; 山口 摂崇; 植田 耕一郎; 菊谷 武; 平野 浩彦; 渡邊 裕; 小坂 健; 藤井 航; 北原 稔; 仲山 智恵; 早淵 仁美; 飯島 勝矢; 介護予防; 日常生活支援総合事業における口腔機能; 栄養; 運動複合型プログラムを用いた住民参加型介護予防活動に関する調査研究; 研究班, 日本老年医学会雑誌, 54, Suppl., 38, 38, May 2017
(一社)日本老年医学会, Japanese

Frailtyへの移行に咀嚼機能の低下が及ぼす影響
堀部 耕広; 渡邊 裕; 平野 浩彦; 枝広 あや子; 本川 佳子; 白部 麻樹; 大渕 修一; 大神 浩一郎; 上田 貴之; 櫻井 薫, 日本老年医学会雑誌, 54, Suppl., 130, 131, May 2017
(一社)日本老年医学会, Japanese

アルツハイマー型認知症(AD)とレビー小体型認知症(DLB)の食行動特性の比較検討
須磨 紫乃; 渡邊 裕; 平野 浩彦; 枝広 あや子; 白部 麻樹; 本川 佳子; 木村 藍; 松下 健二; 荒井 秀典; 櫻井 孝, 日本老年医学会雑誌, 54, Suppl., 131, 131, May 2017
(一社)日本老年医学会, Japanese

口腔機能低下の重複『オーラルフレイル』は要介護認定・総死亡リスクを高める 柏スタディーより
田中 友規; 高橋 競; 平野 浩彦; 渡邊 裕; 菊谷 武; 古屋 裕康; 小原 由紀; 辻 哲夫; 秋下 雅弘; 飯島 勝矢, 日本老年医学会雑誌, 54, Suppl., 134, 134, May 2017
(一社)日本老年医学会, Japanese

都市部在住の後期高齢女性における認知機能低下の関連要因 2年後の追跡分析より
金 憲経; 小島 成実; 藤野 健; 大須賀 洋祐; 吉田 祐子; 渡邊 裕; 井原 一成; 平野 浩彦, 日本老年医学会雑誌, 54, Suppl., 142, 143, May 2017
(一社)日本老年医学会, Japanese

地域在住高齢者における咀嚼機能と栄養素・食品群別摂取量および低栄養との関わり
本川 佳子; 枝広 あや子; 村上 正治; 白部 麻樹; 田中 弥生; 河合 恒; 大渕 修一; 平野 浩彦; 渡邊 裕, 日本老年医学会雑誌, 54, Suppl., 205, 205, May 2017
(一社)日本老年医学会, Japanese

【歯と口をもっと知ろう!-栄養から歯科につなぐための基礎知識】 口の粘膜疾患の基礎知識
森 美由紀; 渡邊 裕, 臨床栄養, 130, 4, 434, 440, Apr. 2017
医歯薬出版(株), Japanese

後期高齢者の口腔機能を改善する診療ガイドラインに関する研究 オーラルフレイル概念を基軸にした検討
櫻井 薫; 平野 浩彦; 菊谷 武; 片倉 朗; 山崎 裕; 飯島 勝矢; 吉田 光由; 戸原 玄; 渡邊 裕, 日本歯科医学会誌, 36, 38, 42, Mar. 2017
日本歯科医学会, Japanese

地域在住高齢者の口腔機能の低下とフレイルの関係について
渡邊 裕, 老年歯科医学, 31, 4, 405, 411, Mar. 2017
「ささいな口の衰え」が口だけの問題でなく、全身の衰えと大きく関わっていること、身体、精神・心理、社会といった多面性を持つフレイルに対して、口腔機能の維持改善だけでなく栄養、運動など包括的な介入が重要であることを地域において一つ一つ事例を重ねながら検証し、啓発してゆく必要がある。フレイルについて、栄養面のフレイル期における口腔機能の低下、口腔機能の低下に対する戦略について述べた。, (一社)日本老年歯科医学会, Japanese

アルツハイマー病高齢者における認知症重症度別、身体組成・栄養指標に関する検討
本川 佳子; 田中 弥生; 菅 洋子; 細山田 洋子; 枝広 あや子; 高城 大輔; 平野 浩彦; 渡邊 裕, 日本静脈経腸栄養学会雑誌, 32, 1, 851, 857, Mar. 2017
(株)ジェフコーポレーション, Japanese

二次予防事業における口腔機能向上の取り組みについて
川村 孝子; 遠藤 孝子; 山口 柳子; 甫仮 貴子; 菅原 彰将; 加藤 洋介; 森下 志穂; 渡邊 裕, 秋田県公衆衛生学雑誌, 13, 1, 8, 11, Mar. 2017
65歳以上の者に対して、生活機能評価「基本チェックリスト」に基づく判定を行い、介入が必要とされた対象者には、介護予防事業(二次予防事業)への参加案内を行った。口腔機能向上プログラムは、対象者が主体的に参加できる内容とした。口腔機能向上単独プログラム参加者(単独群)と、口腔及び運動器の機能向上複合プログラム参加者(複合群)における事業実施前後のアセスメント評価を比較した。咬筋触診の状態は、単独群では有意な変化は認めなかったが、複合群では有意な改善を認め、咬合力の改善が示唆された。器質面、主観的健康観、基本チェックリストは、両群とも改善を示した。また複合群の運動機能面においては、開眼片足立ちやTimed Up and Go Testで改善・維持の割合が多い傾向にあった。参加のし易さや、継続や社会参加への意欲につながったとの声も聞かれ、介護予防の複合的なプログラムの提供は、総合事業におけるハイリスク者への有効な方策の一つになると思われた。, 秋田県公衆衛生学会, Japanese

二次予防事業対象者における口腔機能向上および運動器機能向上の複合サービスの効果と今後の課題
川村 孝子; 遠藤 孝子; 山口 柳子; 甫仮 貴子; 菅原 彰将; 加藤 洋介; 森下 志穂; 渡邊 裕, 秋田県公衆衛生学雑誌, 13, 1, 32, 32, Mar. 2017
秋田県公衆衛生学会, Japanese

フレイルの社会的側面が高齢者の転倒の発生におよぼす影響
藤原佳典; 河合恒; 鈴木宏幸; 小川将; 桜井良太; 安永正史; 深谷太郎; 平野浩彦; 渡邊裕; 井原一成; 大渕修一, 日本疫学会学術総会講演集(Web), 27th, 85 (WEB ONLY), 25 Jan. 2017
Japanese

【サルコペニアとフレイル-最新知見から考えるその高齢社会における意義-】 口腔機能とフレイル
渡邊 裕; 本川 佳子, Geriatric Medicine, 55, 1, 45, 49, Jan. 2017
(株)ライフ・サイエンス, Japanese

要介護高齢者の転帰と栄養関連指標の関係 特別養護老人ホームにおける長期観察研究
本川 佳子; 安田 純; 枝広 あや子; 田中 弥生; 平野 浩彦; 渡邊 裕, 日本静脈経腸栄養学会雑誌, 32, Suppl., 333, 333, Jan. 2017
(株)ジェフコーポレーション, Japanese

要介護高齢者の転帰と栄養関連指標の関係 特別養護老人ホームにおける長期観察研究
本川 佳子; 安田 純; 枝広 あや子; 田中 弥生; 平野 浩彦; 渡邊 裕, 日本静脈経腸栄養学会雑誌, 32, Suppl., 478, 478, Jan. 2017
(株)ジェフコーポレーション, Japanese

咬合機能回復からフレイルの予防・脱却を目指す健康増進支援システムの構築
玉置 勝司; 平野 浩彦; 渡邊 裕; 新開 省二; 飯島 勝矢; 松永 善充, 神奈川歯学, 51, 抄録集, 29, 29, Dec. 2016
神奈川歯科大学学会, Japanese

【オーラルフレイル予防と健康づくり】 オーラルフレイル予防と健康づくり
渡邊 裕; 本川 佳子, 介護福祉・健康づくり, 3, 2, 96, 100, Dec. 2016
日本介護予防・健康づくり学会, Japanese

サルコペニア・フレイル対策と栄養 栄養からオーラルフレイルへの対応を考える
渡邊 裕, 日本病態栄養学会誌, 20, Suppl., S, 4, Dec. 2016
(一社)日本病態栄養学会, Japanese

"今"知っておきたいキーワード 高齢者編(最終回) 高齢者の睡眠
渡邊 裕, The Quintessence, 35, 11, 2512, 2513, Nov. 2016
クインテッセンス出版(株), Japanese

【オーラルフレイルを知る 老年歯科学からの提言】 地域高齢者におけるオーラルフレイル ささいな気づきの啓発
渡邊 裕; 本川 佳子, 日本老年医学会雑誌, 53, 4, 334, 339, Oct. 2016
(一社)日本老年医学会, Japanese

日本の地域在住高齢者における栄養状態とサルコペニア重症度の関連性の検討 BMI、Alb、体重減少の有無との関連
駒井 さつき; 渡邊 裕; 藤原 佳典; 金 憲経; 枝広 あや子; 河合 恒; 吉田 英世; 大渕 修一; 田中 弥生; 平野 浩彦, 日本老年医学会雑誌, 53, 4, 387, 395, Oct. 2016
(一社)日本老年医学会, Japanese

二次予防事業における複合プログラムの効果検証
塚本 真弓; 渡邊 裕; 土田 満; 山口 ひさ子, 日本公衆衛生学会総会抄録集, 75回, 501, 501, Oct. 2016
日本公衆衛生学会, Japanese

要介護高齢者の口腔・栄養管理のガイドライン作成の試み
本橋 佳子; 渡邊 裕; 枝広 あや子; 白部 麻樹; 本川 佳子; 平野 浩彦; 吉田 英世; 小原 由紀; 大河内 二郎; 安藤 雄一, 日本公衆衛生学会総会抄録集, 75回, 520, 520, Oct. 2016
日本公衆衛生学会, Japanese

地域在住後期高齢者における口腔機能検査の受診希望と関連する因子の検討
白部 麻樹; 渡邊 裕; 小原 由紀; 枝広 あや子; 本橋 佳子; 本川 佳子; 河合 恒; 井原 一成; 平野 浩彦; 藤原 佳典; 吉田 英世; 大渕 修一, 日本公衆衛生学会総会抄録集, 75回, 555, 555, Oct. 2016
日本公衆衛生学会, Japanese

【オーラルフレイルの現状と課題】 オーラルフレイル 食欲も含めた包括的介入
渡邊 裕; 本川 佳子, Progress in Medicine, 36, 9, 1193, 1198, Sep. 2016
(株)ライフ・サイエンス, Japanese

"今"知っておきたいキーワード 高齢者編 地域包括ケア
渡邊 裕, The Quintessence, 35, 9, 80, 81, Sep. 2016
クインテッセンス出版(株), Japanese

高齢期における口腔機能低下 学会見解論文 2016年度版
水口 俊介; 津賀 一弘; 池邉 一典; 上田 貴之; 田村 文誉; 永尾 寛; 古屋 純一; 松尾 浩一郎; 山本 健; 金澤 学; 渡邊 裕; 平野 浩彦; 菊谷 武; 櫻井 薫; 一般社団法人日本老年歯科医学会学術委員会, 老年歯科医学, 31, 2, 81, 99, Sep. 2016
(一社)日本老年歯科医学会, Japanese

高齢者に発症した習慣性顎関節脱臼に対し顎関節自己血注入療法を施行した3例
潮田 高志; 渡邊 裕; 山根 源之, 老年歯科医学, 31, 2, 134, 140, Sep. 2016
(一社)日本老年歯科医学会, Japanese

高齢者のフレイルとオーラル・フレイルの関連に関する検討 要介護高齢者の四肢骨格筋量と咬筋厚の関連より
梅木 賢人; 平野 浩彦; 渡邊 裕; 小原 由紀; 枝広 あや子; 本川 佳子; 村上 正治; 須磨 紫乃; 森下 志穂; 白部 麻樹; 五十嵐 憲太郎; 河相 安彦, 老年歯科医学, 31, 2, 149, 149, Sep. 2016
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における咬合力および咀嚼能力の低下とフレイルとの関連
堀部 耕広; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 本川 佳子; 白部 麻樹; 吉田 英世; 大渕 修一; 上田 貴之; 櫻井 薫, 老年歯科医学, 31, 2, 150, 151, Sep. 2016
(一社)日本老年歯科医学会, Japanese

地域自立高齢者における定期歯科受診と歯科医院における保健指導の現状
久保田 チエコ; 守屋 信吾; 渡邊 裕; 濱 洋平; 水口 俊介, 老年歯科医学, 31, 2, 161, 162, Sep. 2016
(一社)日本老年歯科医学会, Japanese

地域自立高齢者の臼歯部咬合支持と食事摂取状況・体格との関連性
守屋 信吾; 久保田 チエコ; 渡邊 裕; 村松 真澄; 豊下 祥史; 川西 克弥; 越野 寿, 老年歯科医学, 31, 2, 165, 165, Sep. 2016
(一社)日本老年歯科医学会, Japanese

要介護高齢者の口腔機能および栄養状態の経年変化 2年間の縦断データ分析
小原 由紀; 森下 志穂; 白部 麻樹; 本川 佳子; 枝広 あや子; 渡邊 裕; 平野 浩彦, 老年歯科医学, 31, 2, 189, 190, Sep. 2016
(一社)日本老年歯科医学会, Japanese

地域在住高齢者の歯周疾患実態調査報告 口腔の状態と機能、および全身との関連
白部 麻樹; 平野 浩彦; 小原 由紀; 飯島 勝矢; 菊谷 武; 本川 佳子; 村上 正治; 枝広 あや子; 渡邊 裕, 老年歯科医学, 31, 2, 191, 191, Sep. 2016
(一社)日本老年歯科医学会, Japanese

軽度認知障害(MCI)高齢者の口腔機能低下に関する研究
森下 志穂; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 村上 正治; 菊谷 武, 老年歯科医学, 31, 2, 191, 192, Sep. 2016
(一社)日本老年歯科医学会, Japanese

アルツハイマー病と軽度認知障害の食行動に関連した特性の比較
須磨 紫乃; 渡邊 裕; 松下 健二; 森下 志穂; 小原 由紀; 白部 麻樹; 本川 佳子; 枝広 あや子; 平野 浩彦, 老年歯科医学, 31, 2, 198, 199, Sep. 2016
(一社)日本老年歯科医学会, Japanese

認知症高齢者に対する適時適切な歯科治療の提供に資する検討 FASTを基準に
枝広 あや子; 平野 浩彦; 渡邊 裕; 村上 正治; 白部 麻樹; 本川 佳子; 須磨 紫乃; 小原 由紀; 森下 志穂; 粟田 主一, 老年歯科医学, 31, 2, 199, 200, Sep. 2016
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における残存歯数と聴力の関連に関する検討
伊藤 誠康; 梅木 賢人; 平野 浩彦; 五十嵐 憲太郎; 吉田 英世; 渡邊 裕; 大渕 修一; 井上 正安; 郡司 敦子; 木本 統; 河相 安彦, 老年歯科医学, 31, 2, 266, 266, Sep. 2016
(一社)日本老年歯科医学会, Japanese

【オーラルフレイル 今、歯科医師が考えるべきこと、できること】
岩佐 康行; 荒井 秀典; 渡邊 裕, The Quintessence, 35, 8, 52, 68, Aug. 2016
クインテッセンス出版(株), Japanese

特別養護老人ホーム入所者の食支援と口腔の管理に関する実態調査報告
金久 弥生; 坂本 まゆみ; 森下 志穂; 池山 豊子; 小原 由紀; 原 久美子; 平野 浩彦; 渡邊 裕, 日本歯科衛生学会雑誌, 11, 1, 104, 104, Aug. 2016
日本歯科衛生学会, Japanese

地域在住高齢者の口腔機能に関する実態調査報告 年齢5歳ごとの変化率の検討
白部 麻樹; 渡邊 裕; 平野 浩彦; 小原 由紀; 枝広 あや子; 村上 正治; 本川 佳子; 恒石 美登里; 吉田 英世; 大渕 修一, 日本歯科衛生学会雑誌, 11, 1, 135, 135, Aug. 2016
日本歯科衛生学会, Japanese

"今"知っておきたいキーワード 高齢者編 軽度認知障害(MCI)
渡邊 裕, The Quintessence, 35, 7, 1568, 1569, Jul. 2016
クインテッセンス出版(株), Japanese

認知症患者の歯科治療に対する疑問と問題点 Clinical Question調査から
服部 佳功; 枝広 あや子; 渡邊 裕; 平野 浩彦; 古屋 純一; 中島 純子; 田村 文誉; 北川 昇; 堀 一浩; 原 哲也; 吉川 峰加; 西 恭宏; 永尾 寛; 市川 哲雄; 櫻井 薫; 一般社団法人日本老年歯科医学会ガイドライン委員会, 老年歯科医学, 31, 1, 3, 8, Jun. 2016
(一社)日本老年歯科医学会, Japanese

都市部在住高齢者を対象とした歯周疾患実態調査
白部 麻樹; 平野 浩彦; 小原 由紀; 枝広 あや子; 渡邊 裕; 吉田 英世; 大渕 修一, 老年歯科医学, 31, 1, 18, 27, Jun. 2016
(一社)日本老年歯科医学会, Japanese

口腔機能と全身機能低下、フレイルとの関係を考える 地域在住高齢者の口腔機能および全身機能の低下とフレイルの関係について
渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 74, 74, Jun. 2016
(一社)日本老年歯科医学会, Japanese

口腔管理の実際 口腔咽頭吸引の理論と実際
菅 武雄; 米山 武義; 菊谷 武; 吉田 光由; 渡邊 裕; 渡部 芳彦; 花形 哲夫; 猪原 光; 星野 由美; 飯田 良平, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 109, 109, Jun. 2016
(一社)日本老年歯科医学会, Japanese

高齢者のフレイルとオーラル・フレイルの関連に関する検討 要介護高齢者の四肢骨格筋量と咬筋厚の関連より
梅木 賢人; 平野 浩彦; 渡邊 裕; 小原 由紀; 枝広 あや子; 本川 佳子; 村上 正治; 須磨 紫乃; 森下 志穂; 白部 麻樹; 五十嵐 憲太郎; 河相 安彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 117, 117, Jun. 2016
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における咬合力および咀嚼能力の低下とフレイルとの関連
堀部 耕広; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 本川 佳子; 白部 麻樹; 吉田 英世; 大渕 修一; 上田 貴之; 櫻井 薫, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 118, 118, Jun. 2016
(一社)日本老年歯科医学会, Japanese

地域自立高齢者の臼歯部咬合支持と食事摂取状況・体格との関連性
守屋 信吾; 久保田 チエコ; 渡邊 裕; 村松 真澄; 豊下 祥史; 川西 克弥; 越野 寿, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 132, 132, Jun. 2016
(一社)日本老年歯科医学会, Japanese

要介護高齢者の口腔機能および栄養状態の経年変化 2年間の縦断データの分析
小原 由紀; 森下 志穂; 白部 麻樹; 本川 佳子; 枝広 あや子; 渡邊 裕; 平野 浩彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 153, 153, Jun. 2016
(一社)日本老年歯科医学会, Japanese

地域在住高齢者の歯周疾患実態調査報告
白部 麻樹; 平野 浩彦; 小原 由紀; 飯島 勝矢; 菊谷 武; 本川 佳子; 村上 正治; 枝広 あや子; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 154, 154, Jun. 2016
(一社)日本老年歯科医学会, Japanese

軽度認知障害(MCI)高齢者の口腔機能低下に関する研究
森下 志穂; 渡邊 裕; 平野 浩彦; 枝広 あや子; 小原 由紀; 村上 正治; 菊谷 武, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 155, 155, Jun. 2016
(一社)日本老年歯科医学会, Japanese

アルツハイマー型認知症(AD)と軽度認知機能障害(MCI)の特性の比較検討
須磨 紫乃; 渡邊 裕; 森下 志穂; 小原 由紀; 白部 麻樹; 本川 佳子; 枝広 あや子; 平野 浩彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 160, 160, Jun. 2016
(一社)日本老年歯科医学会, Japanese

認知症高齢者に対する適時適切な歯科治療の提供に資する検討 FASTを基準に
枝広 あや子; 平野 浩彦; 渡邊 裕; 村上 正治; 白部 麻樹; 本川 佳子; 須磨 紫乃; 小原 由紀; 森下 志穂; 粟田 主一, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 161, 161, Jun. 2016
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における残存歯数と聴力の関連に関する検討
伊藤 誠康; 梅木 賢人; 平野 浩彦; 五十嵐 憲太郎; 吉田 英世; 渡邊 裕; 大渕 修一; 井上 正安; 郡司 敦子; 木本 統; 河相 安彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 27回, 212, 212, Jun. 2016
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における咀嚼機能に対するフレイルの影響
堀部 耕広; 平野 浩彦; 渡邊 裕; 石崎 憲; 上田 貴之; 櫻井 薫, 歯科学報, 116, 3, 236, 236, Jun. 2016
東京歯科大学学会, Japanese

"今"知っておきたいキーワード 高齢者編 ロコモティブシンドローム
渡邊 裕, The Quintessence, 35, 5, 1080, 1081, May 2016
クインテッセンス出版(株), Japanese

地域在住高齢者を対象としたフレイルと栄養状態の検討
本川 佳子; 枝広 あや子; 渡邊 裕; 吉田 英世; 大渕 修一; 河合 恒; 解良 武士; 井原 一成; 藤原 佳典; 平野 浩彦, 日本老年医学会雑誌, 53, Suppl., 169, 169, May 2016
(一社)日本老年医学会, Japanese

"今"知っておきたいキーワード 高齢者編 サルコペニア
渡邊 裕, The Quintessence, 35, 3, 0568, 0569, Mar. 2016
クインテッセンス出版(株), Japanese

"今"知っておきたいキーワード 高齢者編 フレイル
渡邊 裕, The Quintessence, 35, 1, 100, 101, Jan. 2016
クインテッセンス出版(株), Japanese

高齢者の食欲不振へのアプローチ 心理的な原因に対するアプローチによる改善例
今泉 良典; 木下 かほり; 小出 由美子; 渡邊 裕; 佐竹 昭介; 山岡 朗子, 日本静脈経腸栄養学会雑誌, 31, 1, 461, 461, Jan. 2016
(株)ジェフコーポレーション, Japanese

【地域連携における歯科の役割】 誤嚥性肺炎を予防する口腔ケアで、医療費削減
渡邊 裕, 8020: はち・まる・にい・まる, 15, 92, 95, Jan. 2016
(公財)8020推進財団, Japanese

【クリティカルケア領域における 口腔ケアベストプラクティス】 (Part2)クリティカルケア領域における口腔ケアに必要な知識 口腔の微生物学的環境
渡邊 裕, 看護技術, 61, 13, 1344, 1347, Nov. 2015
(株)メヂカルフレンド社, Japanese

オーラル・フレイルとは
渡邊 裕, 臨床栄養, 127, 6, 742, 744, Nov. 2015
医歯薬出版(株), Japanese

高齢者の食を支えるために オーラル・フレイルの概念を討議する フレイル高齢者の口腔機能低下について
渡邊 裕, メディカル朝日, 44, 11, 42, 43, Nov. 2015
(株)朝日新聞社, Japanese

【高齢者医療での歯科に関するMinimum Skills】 糖尿病患者の口腔管理
渡邊 裕, Geriatric Medicine, 53, 11, 1163, 1166, Nov. 2015
(株)ライフ・サイエンス, Japanese

アルツハイマー病高齢者の摂食嚥下機能と栄養状態の変遷 FASTステージ別の検討
枝広 あや子; 平野 浩彦; 渡邊 裕; 小原 由紀; 本川 佳子; 白部 麻樹; 粟田 主一, Dementia Japan, 29, 3, 349, 349, Sep. 2015
(一社)日本認知症学会, Japanese

地域在住高齢者の食欲減退がサルコペニアに及ぼす影響 食欲指標(SNAQ)を用いた検討
高城 大輔; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 白部 麻樹; 大渕 修一; 吉田 英世; 藤原 佳典; 河合 恒; 金 憲経; 井原 一成; 弘中 祥司, 老年歯科医学, 30, 2, 104, 105, Sep. 2015
(一社)日本老年歯科医学会, Japanese

フレイルと口腔機能の関係 大規模地域在住高齢者調査より
森下 志穂; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 村上 正治; 菊谷 武; 鈴木 隆雄, 老年歯科医学, 30, 2, 107, 108, Sep. 2015
(一社)日本老年歯科医学会, Japanese

地域自立高齢者における知的能力、教育歴と定期歯科受診との関連性
久保田 チエコ; 守屋 信吾; 渡邊 裕; 濱 洋平; 水口 俊介, 老年歯科医学, 30, 2, 117, 118, Sep. 2015
(一社)日本老年歯科医学会, Japanese

地域自立高齢者における社会的健康格差要因 歯数についての分析
守屋 信吾; 久保田 チエコ; 渡邊 裕; 村松 真澄; 豊下 祥史; 川西 克弥; 越野 寿, 老年歯科医学, 30, 2, 137, 138, Sep. 2015
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における食欲減退の関連因子に関する検討 基本チェックリストを用いた検討
高城 大輔; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 白部 麻樹; 大渕 修一; 吉田 英世; 村上 浩史; 弘中 祥司, 老年歯科医学, 30, 2, 149, 150, Sep. 2015
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における口腔機能および栄養状態の変化 5年間の追跡調査から
小原 由紀; 枝広 あや子; 森下 志穂; 渡邊 裕; 平野 浩彦, 老年歯科医学, 30, 2, 178, 178, Sep. 2015
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における四肢骨格筋量と咬筋厚の関連に関する検討
梅木 賢人; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 高城 大輔; 白部 麻樹; 吉田 英世; 大渕 修一; 弘中 祥司; 河相 安彦, 老年歯科医学, 30, 2, 180, 181, Sep. 2015
(一社)日本老年歯科医学会, Japanese

認知症高齢者の口腔機能の経時変化 FASTを基準にした縦断調査からの検討
枝広 あや子; 平野 浩彦; 渡邊 裕; 弘中 祥司; 小原 由紀; 森下 志穂; 高城 大輔; 白部 麻樹, 老年歯科医学, 30, 2, 194, 195, Sep. 2015
(一社)日本老年歯科医学会, Japanese

地域在住後期高齢者における低栄養と咀嚼機能低下および嚥下機能低下との関連
堀部 耕広; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 高城 大輔; 白部 麻樹; 吉田 英世; 大渕 修一; 上田 貴之; 弘中 祥司; 櫻井 薫, 老年歯科医学, 30, 2, 231, 232, Sep. 2015
(一社)日本老年歯科医学会, Japanese

地域在住高齢者の歯周疾患実態調査報告
白部 麻樹; 平野 浩彦; 小原 由紀; 枝広 あや子; 渡邊 裕; 吉田 英世; 大渕 修一, 老年歯科医学, 30, 2, 233, 234, Sep. 2015
(一社)日本老年歯科医学会, Japanese

通所サービス利用者における口腔機能向上および栄養改善の複合サービスの長期介入効果
森下 志穂; 渡邊 裕; 平野 浩彦; 枝広 あや子; 小原 由紀; 後藤 百合; 柴田 雅子; 長尾 志保; 三角 洋美, 日本歯科衛生学会雑誌, 10, 1, 103, 103, Aug. 2015
日本歯科衛生学会, Japanese

二次予防事業対象者における口腔機能向上および運動器機能向上の複合サービスの効果
川村 孝子; 遠藤 孝子; 山口 柳子; 甫仮 貴子; 菅原 彰将; 加藤 洋介; 森下 志穂; 渡邊 裕, 日本歯科衛生学会雑誌, 10, 1, 104, 104, Aug. 2015
日本歯科衛生学会, Japanese

二次予防対象高齢者における複合プログラム介入の効果検証
柴田 真弓; 渡邊 裕; 平野 浩彦; 森下 志穂; 小原 由紀; 後藤 百合; 河原 千里; 三角 洋美; 山口 ひさ子; 土田 満, 日本歯科衛生学会雑誌, 10, 1, 105, 105, Aug. 2015
日本歯科衛生学会, Japanese

VAP予防に関する口腔ケアの現状と今後の展望について
渡邊 裕, 日本クリティカルケア看護学会誌, 11, 2, 96, 96, Jun. 2015
(一社)日本クリティカルケア看護学会, Japanese

日本人地域在住高齢者における口腔機能と抑うつとの関連性について
村上 正治; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 片倉 朗, 心身医学, 55, 6, 754, 754, Jun. 2015
(一社)日本心身医学会, Japanese

高齢者の食を支えるために オーラルフレイルの概念を討議する フレイル高齢者の口腔機能低下について
渡邊 裕, 日本老年医学会雑誌, 52, Suppl., 8, 8, May 2015
(一社)日本老年医学会, Japanese

地域在住高齢者の食欲減退がサルコペニアに及ぼす影響 食欲指標(SNAQ)を用いた検討
高城 大輔; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 白部 麻樹; 大渕 修一; 吉田 英世; 藤原 佳典; 河合 恒; 金 憲経; 井原 一成; 弘中 祥司, 日本老年医学会雑誌, 52, Suppl., 55, 55, May 2015
(一社)日本老年医学会, Japanese

地域在住高齢者におけるサルコペニア重度化の背景要因の検討 栄養関連項目を中心に
駒井 さつき; 高城 大輔; 小原 由紀; 枝広 あや子; 渡邊 裕; 田中 弥生; 藤原 佳典; 大渕 修一; 吉田 英世; 平野 浩彦, 日本老年医学会雑誌, 52, Suppl., 97, 98, May 2015
(一社)日本老年医学会, Japanese

アルツハイマー病高齢者における認知症重症度を基準とした栄養状態横断調査 Clinical Dementia Rating(CDR)を用いた検討
本川 佳子; 平野 浩彦; 枝広 あや子; 渡邊 裕; 小原 由紀; 駒井 さつき, 日本老年医学会雑誌, 52, Suppl., 106, 106, May 2015
(一社)日本老年医学会, Japanese

地域在住高齢者の食欲減退がサルコペニアに及ぼす影響 食欲指標(SNAQ)を用いた検討
高城 大輔; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 白部 麻樹; 大渕 修一; 吉田 英世; 藤原 佳典; 河合 恒; 金 憲経; 井原 一成; 弘中 祥司, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 109, 109, May 2015
(一社)日本老年歯科医学会, Japanese

フレイルと口腔機能の関係 大規模地域在住高齢者調査より
森下 志穂; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 村上 正治; 菊谷 武; 鈴木 隆雄, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 114, 114, May 2015
(一社)日本老年歯科医学会, Japanese

地域自立高齢者における知的能力、教育歴と定期歯科受診との関連性
久保田 チエコ; 守屋 信吾; 渡邊 裕; 濱 洋平; 水口 俊介, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 124, 124, May 2015
(一社)日本老年歯科医学会, Japanese

地域自立高齢者における社会的健康格差要因 歯数との関連性
守屋 信吾; 久保田 チエコ; 渡邊 裕; 村松 真澄; 豊下 祥史; 川西 克弥; 越野 寿, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 140, 140, May 2015
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における食欲減退の背景因子に関する検討
高城 大輔; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 白部 麻樹; 大渕 修一; 吉田 英世; 村上 浩史; 弘中 祥司, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 153, 153, May 2015
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における口腔機能および栄養状態の変化 5年間の追跡調査から
小原 由紀; 枝広 あや子; 森下 志穂; 渡邊 裕; 平野 浩彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 173, 173, May 2015
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における四肢骨格筋量と咬筋厚の関連に関する検討
梅木 賢人; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 高城 大輔; 白部 麻樹; 吉田 英世; 大渕 修一; 弘中 祥司; 河相 安彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 175, 175, May 2015
(一社)日本老年歯科医学会, Japanese

認知症高齢者の口腔機能の経時変化 FASTを基準にした縦断調査からの検討
枝広 あや子; 平野 浩彦; 渡邊 裕; 弘中 祥司; 小原 由紀; 森下 志穂; 高城 大輔; 白部 麻樹, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 184, 184, May 2015
(一社)日本老年歯科医学会, Japanese

地域在住後期高齢者における低栄養と咀嚼機能低下および嚥下機能低下との関連
堀部 耕広; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 高城 大輔; 白部 麻樹; 吉田 英世; 大渕 修一; 上田 貴之; 弘中 祥司; 櫻井 薫, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 210, 210, May 2015
(一社)日本老年歯科医学会, Japanese

地域在住高齢者の歯周疾患実態調査報告
白部 麻樹; 平野 浩彦; 小原 由紀; 枝広 あや子; 渡邊 裕; 吉田 英世; 大渕 修一, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 26回, 211, 211, May 2015
(一社)日本老年歯科医学会, Japanese

地域在住二次予防高齢者に対する複合プログラムの開発と効果検証
渡邊 裕; 守屋 信吾; 小原 由紀; 枝広 あや子, 口腔衛生学会雑誌, 65, 2, 196, 196, Apr. 2015
(一社)日本口腔衛生学会, Japanese

認知症グループホーム入居高齢者における認知症重症度と口腔機能および栄養状態の関連
小原 由紀; 高城 大輔; 枝広 あや子; 森下 志穂; 渡邊 裕; 平野 浩彦, 日本歯科衛生学会雑誌, 9, 2, 69, 79, Feb. 2015
日本歯科衛生学会, Japanese

当院の認知症患者における拒食に対する介入例
木下 かほり; 朝倉 三恵子; 小出 由美子; 間瀬 広樹; 金子 康彦; 渡邊 裕; 佐竹 昭介; 山岡 朗子, 日本静脈経腸栄養学会雑誌, 30, 1, 450, 450, Jan. 2015
(株)ジェフコーポレーション, Japanese

地域在住高齢者の咀嚼機能低下と咀嚼困難感の背景因子の検討
高城 大輔; 平野 浩彦; 渡邉 裕; 枝広 あや子; 小原 由紀; 森下 志穂; 村上 正治; 村上 浩史; 弘中 祥司, 老年歯科医学, 29, 2, 140, 140, Sep. 2014
(一社)日本老年歯科医学会, Japanese

口腔ケア 感染症対策としての口腔ケアを考える
渡邊 裕, 難病と在宅ケア, 20, 6, 53, 56, Sep. 2014
(株)日本プランニングセンター, Japanese

日本人地域在住高齢者における咀嚼機能とサルコペニアの関連性について
村上 正治; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 森下 志穂; 片倉 朗, 老年歯科医学, 29, 2, 88, 88, Sep. 2014
(一社)日本老年歯科医学会, Japanese

要介護高齢者の口腔湿潤度ならびに口腔内細菌に関する実態調査報告
鰕原 賀子; 平野 浩彦; 枝広 あや子; 小原 由紀; 渡邊 裕; 森下 志穂; 本橋 佳子; 菅 武雄; 村上 正治; 植田 耕一郎; 菊谷 武, 老年歯科医学, 29, 2, 116, 117, Sep. 2014
(一社)日本老年歯科医学会, Japanese

地域在住二次予防高齢者における食欲と栄養障害リスクを改善する複合プログラムの検討
奥村 圭子; 徳留 裕子; 渡邊 裕; 森下 志穂; 本橋 佳子; 平野 浩彦; 枝広 あや子; 小原 由紀; 村上 正治; 鈴木 隆雄, 老年歯科医学, 29, 2, 169, 170, Sep. 2014
(一社)日本老年歯科医学会, Japanese

高齢者ブレインバンクでのレビー小体型認知症診断症例における摂食嚥下障害の状況について(第一報)
本橋 佳子; 渡邊 裕; 木村 絵美子; 平野 浩彦; 枝広 あや子, 老年歯科医学, 29, 2, 175, 175, Sep. 2014
(一社)日本老年歯科医学会, Japanese

認知症重度化にともなう口腔関連機能の変遷 Functional Assessment Staging(FAST)を基準にした検討
枝広 あや子; 平野 浩彦; 小原 由紀; 渡邊 裕; 森下 志穂; 村上 正治; 高城 大輔, 老年歯科医学, 29, 2, 176, 177, Sep. 2014
(一社)日本老年歯科医学会, Japanese

アルツハイマー型認知症高齢者の摂食嚥下機能と栄養状態に関する報告 低栄養リスク因子の検討
高城 大輔; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 森下 志穂; 大堀 嘉子; 村上 浩史; 弘中 祥司, 老年歯科医学, 29, 2, 178, 179, Sep. 2014
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における口腔乾燥感に関連する要因の検討 2年間の縦断データから
小原 由紀; 大渕 修一; 吉田 英世; 渡邊 裕; 平野 浩彦, 老年歯科医学, 29, 2, 197, 197, Sep. 2014
(一社)日本老年歯科医学会, Japanese

高齢者における体重変化と口腔機能および全身状態の関係
桐原 浩輔; 岩佐 康行; 森下 志穂; 渡邊 裕, 老年歯科医学, 29, 2, 197, 198, Sep. 2014
(一社)日本老年歯科医学会, Japanese

地域在住高齢者を対象とした大規模口腔機能実態調査報告
森下 志穂; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 村上 正治; 菊谷 武; 鈴木 隆雄, 老年歯科医学, 29, 2, 198, 199, Sep. 2014
(一社)日本老年歯科医学会, Japanese

グループホーム入居高齢者における認知症重症度と口腔機能および栄養状態との関連
小原 由紀; 高城 大輔; 枝広 あや子; 森下 志穂; 渡邊 裕; 平野 浩彦, 日本歯科衛生学会雑誌, 9, 1, 170, 170, Aug. 2014
日本歯科衛生学会, Japanese

【超高齢化社会における高齢者感染症の特徴と課題】 高齢者の口腔衛生状態維持(口腔ケア)の重要性
渡邊 裕, 化学療法の領域, 30, 9, 1727, 1734, Aug. 2014
(株)医薬ジャーナル社, Japanese

地域在住高齢者の咀嚼機能低下と咀嚼困難感の背景因子の検討
高城 大輔; 平野 浩彦; 渡邉 裕; 枝広 あや子; 小原 由紀; 森下 志穂; 村上 正治; 村上 浩史; 弘中 祥司, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 144, 144, Jun. 2014
(一社)日本老年歯科医学会, Japanese

アルツハイマー型認知症高齢者の摂食嚥下機能と栄養状態に関する報告
高城 大輔; 平野 浩彦; 渡邉 裕; 枝広 あや子; 小原 由紀; 森下 志穂; 大堀 嘉子, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 171, 171, Jun. 2014
(一社)日本老年歯科医学会, Japanese

【口腔ケアをもっと効果的に行うための3つの視点】 口腔ケアを拒否されたらどうする?
渡邊 裕, ナーシング, 34, 8, 66, 67, Jun. 2014
(株)学研メディカル秀潤社, Japanese

【口腔ケアをもっと効果的に行うための3つの視点】 (視点3)薬だけじゃない、乾燥の原因別の対策で、口腔乾燥をもっと防ぐ!
渡邊 裕, ナーシング, 34, 8, 68, 74, Jun. 2014
(株)学研メディカル秀潤社, Japanese

癌化学療法による口腔粘膜炎のリスクに対する専門的口腔管理の効果に関する研究
齋藤 寛一; 吉田 佳史; 伊川 裕明; 佐藤 一道; 渡邊 裕; 高山 伸; 太田 嘉英; 金子 明寛; 片倉 朗, 日本口腔感染症学会雑誌, 21, 1, 51, 52, Jun. 2014
(一社)日本口腔感染症学会, Japanese

高齢者の口腔機能低下
渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 67, 67, Jun. 2014
(一社)日本老年歯科医学会, Japanese

日本人地域在住高齢者における咀嚼機能の低下がサルコペニアの重度化に及ぼす影響について
村上 正治; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 森下 志穂; 片倉 朗, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 96, 96, Jun. 2014
(一社)日本老年歯科医学会, Japanese

要介護高齢者の口腔湿潤度ならびに口腔内細菌に関する実態調査報告
鰕原 賀子; 平野 浩彦; 枝広 あや子; 小原 由紀; 渡邊 裕; 森下 志穂; 本橋 佳子; 菅 武雄; 村上 正治; 植田 耕一郎; 菊谷 武, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 119, 119, Jun. 2014
(一社)日本老年歯科医学会, Japanese

地域在住二次予防高齢者における食欲と栄養障害リスクを改善する複合プログラムの検討
奥村 圭子; 徳留 裕子; 渡邊 裕; 森下 志穂; 本橋 佳子; 平野 浩彦; 枝広 あや子; 小原 由紀; 村上 正治; 鈴木 隆雄, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 165, 165, Jun. 2014
(一社)日本老年歯科医学会, Japanese

高齢者ブレインバンクでのレビー小体型認知症診断症例における摂食嚥下障害の状況について(第一報)
本橋 佳子; 渡邊 裕; 木村 絵美子; 平野 浩彦; 枝広 あや子, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 169, 169, Jun. 2014
(一社)日本老年歯科医学会, Japanese

認知症重度化にともなう口腔関連機能の変遷 Functional Assessment Staging(FAST)を基準にした検討
枝広 あや子; 平野 浩彦; 小原 由紀; 渡邊 裕; 森下 志穂; 村上 正治; 高城 大輔, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 170, 170, Jun. 2014
(一社)日本老年歯科医学会, Japanese

地域在住高齢者における口腔乾燥感と唾液分泌量低下に関連する要因の検討 2年間の縦断データから
小原 由紀; 大渕 修一; 吉田 英世; 渡邊 裕; 平野 浩彦, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 184, 184, Jun. 2014
(一社)日本老年歯科医学会, Japanese

高齢者における体重変化と口腔機能および全身状態の関係
桐原 浩輔; 岩佐 康行; 森下 志穂; 渡邊 裕, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 185, 185, Jun. 2014
(一社)日本老年歯科医学会, Japanese

地域在住高齢者を対象とした大規模口腔機能実態調査報告
森下 志穂; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 村上 正治; 菊谷 武, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 25回, 185, 185, Jun. 2014
(一社)日本老年歯科医学会, Japanese

8020運動達成後の高齢者咀嚼機能低下のリスク因子としてサルコペニアの可能性
平野 浩彦; 渡邊 裕; 小原 由紀; 枝広 あや子; 藤原 佳典; 河合 恒; 吉田 英世; 井原 一成; 大渕 修一; 金 憲経, 日本老年医学会雑誌, 51, Suppl., 144, 145, May 2014
(一社)日本老年医学会, Japanese

癌化学療法による口腔粘膜炎のリスクに対する専門的口腔管理の効果に関する研究
齋藤 寛一; 吉田 佳史; 伊川 裕明; 佐藤 一道; 渡邊 裕; 片倉 朗, 日本口腔ケア学会雑誌, 8, 1, 89, 89, Mar. 2014
(一社)日本口腔ケア学会, Japanese

特別養護老人ホームの入所者に対する「高齢者のための自立摂食維持マニュアル」の効果について
渡邊 裕; 森下 志穂; 平野 浩彦; 枝広 あや子; 小原 由紀; 田中 弥生; 池山 豊子; 鈴木 隆雄, 老年歯科医学, 28, 2, 88, 89, Sep. 2013
(一社)日本老年歯科医学会, Japanese

終末期高齢者の口を支えるために 多職種アンケート調査から見えてきた終末期歯科医療の役割
菅 武雄; 平野 浩彦; 森戸 光彦; 阪口 英夫; 渡邊 裕; 大野 友久; 山田 律子; 枝広 あや子; 森下 志穂; 小原 由紀, 老年歯科医学, 28, 2, 89, 89, Sep. 2013
(一社)日本老年歯科医学会, Japanese

高齢者咀嚼機能評価の検討 EWGSOPサルコペニア臨床定義と診断基準を参考に
村上 正治; 平野 浩彦; 渡邊 裕; 小原 由紀; 枝広 あや子; 大渕 修一; 吉田 英世; 藤原 佳典; 井原 一成; 河合 恒; 小島 基永; 森下 志穂; 片倉 朗, 老年歯科医学, 28, 2, 89, 90, Sep. 2013
(一社)日本老年歯科医学会, Japanese

介護保険施設における効果的な口腔機能維持管理のあり方に関する調査研究
久保山 裕子; 菊谷 武; 植田 耕一郎; 吉田 光由; 渡邊 裕; 菅 武雄; 阪口 英夫; 木村 年秀; 田村 文誉; 佐藤 保; 森戸 光彦; 一般社団法人日本老年歯科医学会介護保険施設における効果的な口腔機能維持管理のあり方に関する調査研究事業ワーキングチーム, 老年歯科医学, 28, 2, 124, 124, Sep. 2013
(一社)日本老年歯科医学会, Japanese

通所介護施設における栄養改善および口腔機能向上サービスの効果に関する介入調査
森下 志穂; 渡邊 裕; 平野 浩彦; 枝広 あや子; 佐藤 絵美子; 小原 由紀; 田中 弥生; 池山 豊子; 鈴木 隆雄, 老年歯科医学, 28, 2, 158, 159, Sep. 2013
(一社)日本老年歯科医学会, Japanese

要介護高齢者における摂食・嚥下障害に関連する因子の検討 地域悉皆調査からの知見
酒井 克彦; 平野 浩彦; 渡邊 裕; 菅 武雄; 枝広 あや子; 佐藤 絵美子; 村上 正治; 吉田 雅康; 森下 志穂; 小原 由紀; 片倉 朗, 老年歯科医学, 28, 2, 162, 163, Sep. 2013
(一社)日本老年歯科医学会, Japanese

認知症患者の自立摂食を支援するための介入プログラムの効果検証
枝広 あや子; 平野 浩彦; 山田 律子; 佐藤 絵美子; 冨田 かをり; 中川 量晴; 渡邊 裕; 小原 由紀; 大堀 嘉子; 新谷 浩和; 細野 純, 老年歯科医学, 28, 2, 178, 179, Sep. 2013
(一社)日本老年歯科医学会, Japanese

終末期高齢者に対する歯科医療およびマネジメントニーズに関する調査報告
平野 浩彦; 森戸 光彦; 阪口 英夫; 菅 武雄; 渡邊 裕; 大野 友久; 山田 律子; 枝広 あや子; 森下 志穂, 老年歯科医学, 28, 2, 230, 231, Sep. 2013
(一社)日本老年歯科医学会, Japanese

通所介護施設における口腔機能向上および栄養改善の複合サービスの効果に関する介入調査
森下 志穂; 渡邊 裕; 平野 浩彦; 枝広 あや子; 佐藤 絵美子; 小原 由紀; 田中 弥生; 池山 豊子, 日本歯科衛生学会雑誌, 8, 1, 192, 192, Aug. 2013
日本歯科衛生学会, Japanese

特別養護老人ホームの入所者に対する「高齢者のための自立摂食維持マニュアル」の効果について
渡邊 裕; 森下 志穂; 平野 浩彦; 枝広 あや子; 小原 由紀; 田中 弥生; 池山 豊子, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 24回, 89, 89, Jun. 2013
(一社)日本老年歯科医学会, Japanese

終末期高齢者の口を支えるために 多職種アンケート調査から見えてきた終末期歯科医療の役割
菅 武雄; 平野 浩彦; 森戸 光彦; 阪口 英夫; 渡邊 裕; 大野 友久; 山田 律子; 枝広 あや子; 森下 志穂; 小原 由紀, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 24回, 89, 89, Jun. 2013
(一社)日本老年歯科医学会, Japanese

通所介護施設における栄養改善および口腔機能向上サービスの効果に関する介入調査
森下 志穂; 渡邊 裕; 平野 浩彦; 枝広 あや子; 佐藤 絵美子; 小原 由紀; 田中 弥生; 池山 豊子; 鈴木 隆雄, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 24回, 146, 146, Jun. 2013
(一社)日本老年歯科医学会, Japanese

要介護高齢者における摂食・嚥下障害に関連する因子の検討
酒井 克彦; 平野 浩彦; 渡邊 裕; 菅 武雄; 枝広 あや子; 佐藤 絵美子; 村上 正治; 吉田 雅康; 森下 志穂; 小原 由紀; 片倉 朗, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 24回, 149, 149, Jun. 2013
(一社)日本老年歯科医学会, Japanese

認知症高齢者の自立摂食を支援するための介入プログラムの効果検証
枝広 あや子; 平野 浩彦; 山田 律子; 佐藤 絵美子; 冨田 かをり; 中川 量晴; 渡邊 裕; 小原 由紀; 大堀 嘉子; 新谷 浩和; 細野 純; 横浜高齢者グループホーム連絡会, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 24回, 159, 159, Jun. 2013
(一社)日本老年歯科医学会, Japanese

終末期高齢者に対する歯科医療およびマネジメントニーズに関する調査報告
平野 浩彦; 森戸 光彦; 阪口 英夫; 菅 武雄; 渡邊 裕; 大野 友久; 山田 律子; 枝広 あや子; 森下 志穂, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 24回, 195, 195, Jun. 2013
(一社)日本老年歯科医学会, Japanese

高齢者咀嚼機能評価の検討 EWGSOPサルコペニア臨床定義と診断基準を参考に
村上 正治; 平野 浩彦; 渡邊 裕; 小原 由紀; 枝広 あや子; 大渕 修一; 吉田 英世; 藤原 佳典; 井原 一成; 河合 恒; 森下 志穂; 片倉 朗, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 24回, 90, 90, Jun. 2013
(一社)日本老年歯科医学会, Japanese

特別養護老人ホームの入所者に対する「高齢者のための自立摂食維持マニュアル」の効果について
渡邊 裕; 森下 志穂; 平野 浩彦; 枝広 あや子; 小原 由紀; 田中 弥生; 池山 豊子, 日本老年医学会雑誌, 50, Suppl., 125, 125, May 2013
(一社)日本老年医学会, Japanese

終末期高齢者の口を支えるために 多職種アンケート調査から見えてきた終末期歯科医療の役割
菅 武雄; 平野 浩彦; 森戸 光彦; 阪口 英夫; 渡邊 裕; 大野 友久; 山田 律子; 枝広 あや子; 森下 志穂; 小原 由紀, 日本老年医学会雑誌, 50, Suppl., 132, 132, May 2013
(一社)日本老年医学会, Japanese

高齢者咀嚼機能評価の検討 EWGSOPサルコペニア臨床定義と診断基準を参考に
村上 正治; 平野 浩彦; 渡邊 裕; 小原 由紀; 枝広 あや子; 大渕 修一; 吉田 英世; 藤原 佳典; 井原 一成; 河合 恒; 森下 志穂; 片倉 朗, 日本老年医学会雑誌, 50, Suppl., 132, 133, May 2013
(一社)日本老年医学会, Japanese

摂食・嚥下障害に対する軟口蓋挙上装置の有効性
植田 耕一郎; 向井 美惠; 森田 学; 菊谷 武; 渡邊 裕; 戸原 玄; 阿部 仁子; 中山 渕利; 三瓶 龍一; 島野 嵩也; 岡田 猛司; 鰕原 賀子; 石山 寿子, 日本摂食・嚥下リハビリテーション学会雑誌, 17, 1, 13, 24, Apr. 2013
(一社)日本摂食嚥下リハビリテーション学会, Japanese

アルツハイマー型認知症のMNA-SFによる栄養アセスメントと口腔機能の関連
佐藤 絵美子; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 森下 志穂; 片倉 朗, 静脈経腸栄養, 28, 1, 245, 245, Jan. 2013
(株)ジェフコーポレーション, Japanese

口腔がん患者への集学的な精神医学的ケア
村上 正治; 渡邊 裕; 枝広 あや子; 西久保 周一; 佐藤 一道; 山内 智博; 神山 勲; 吉野 文浩; 小板橋 俊哉; 外木 守雄; 山根 源之; 片倉 朗, 日本歯科心身医学会雑誌, 27, 1-2, 78, 78, Dec. 2012
(一社)日本歯科心身医学会, Japanese

重度開口障害を伴う進行性骨化性線維異形成症(FOP)患者の口腔管理における歯科衛生士の役割
雨宮 智美; 藤平 弘子; 酒井 克彦; 山崎 善範; 渡邊 裕; 片倉 朗, 有病者歯科医療, 21, 3, 217, 217, Dec. 2012
(一社)日本有病者歯科医療学会, Japanese

認知症高齢者の口腔機能に関する実態調査報告 アルツハイマー型認知症と血管性認知症の比較
佐藤 絵美子; 平野 浩彦; 渡邊 裕; 新屋 俊明; 戸原 玄; 枝広 あや子; 小原 由紀; 片倉 朗; 外木 守雄; 山根 源之, 有病者歯科医療, 21, 3, 227, 227, Dec. 2012
(一社)日本有病者歯科医療学会, Japanese

アルツハイマー型認知症の嗅覚低下と食行動との関連
平野 浩彦; 渡邊 裕; 佐藤 絵美子; 枝広 あや子; 小原 由紀; 森下 志穂, 日本早期認知症学会プログラム・抄録集, 13回, 113, 113, Sep. 2012
日本早期認知症学会, Japanese

要介護高齢者口腔関連実態調査報告 特定地域悉皆調査からの知見
森下 志穂; 平野 浩彦; 渡邊 裕; 菅 武雄; 枝広 あや子; 小原 由紀; 佐藤 絵美子, 老年歯科医学, 27, 2, 179, 180, Sep. 2012
(一社)日本老年歯科医学会, Japanese

認知症高齢者の口腔機能および嚥下機能実態調査報告 不顕性誤嚥発症リスクの視点から
佐藤 絵美子; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 森下 志穂; 大堀 嘉子; 戸原 玄; 千葉 由美; 新屋 俊明; 山田 律子; 外木 守雄; 片倉 朗; 山根 源之; 鈴木 隆雄, 老年歯科医学, 27, 2, 226, 227, Sep. 2012
(一社)日本老年歯科医学会, Japanese

認知症患者の自立摂食を支援するための介入プログラムの考案
枝広 あや子; 平野 浩彦; 山田 律子; 佐藤 絵美子; 冨田 かをり; 中川 量晴; 渡邊 裕; 小原 由紀; 大堀 嘉子; 新谷 浩和; 細野 純, 老年歯科医学, 27, 2, 227, 228, Sep. 2012
(一社)日本老年歯科医学会, Japanese

当院の人間ドック受診者における歯科受診者の状況
市島 丈裕; 鈴木 大貴; 井口 直彦; 栗山 智宏; 滝沢 裕也; 山崎 喜範; 浮地 賢一郎; 有坂 岳大; 西久保 周一; 宇治川 清登; 武安 嘉大; 佐藤 一道; 高田 篤史; 渡邊 裕; 外木 守雄; 藤平 弘子; 山根 源之; 片倉 朗, 日本歯科人間ドック学会誌, 7, 1, 39, 39, Aug. 2012
(一社)ジャパンオーラルヘルス学会, Japanese

当科における口腔扁平苔癬の診断手順
布施 佑磨; 鈴木 大貴; 井口 直彦; 市島 丈裕; 滝沢 裕也; 栗山 智宏; 山崎 喜範; 浮地 賢一郎; 有坂 岳大; 西久保 周一; 宇治川 清登; 武安 嘉大; 佐藤 一道; 高田 篤史; 渡邊 裕; 外木 守雄; 藤平 弘子; 山根 源之; 片倉 朗, 日本歯科人間ドック学会誌, 7, 1, 41, 42, Aug. 2012
(一社)ジャパンオーラルヘルス学会, Japanese

認知症高齢者の摂食・嚥下障害
平野 浩彦; 枝広 あや子; 高田 靖; 渡邊 裕; 鈴木 隆雄, 日本歯科医師会雑誌, 65, 5, 679, 679, Aug. 2012
(公社)日本歯科医師会, Japanese

脳卒中地域連携クリニカルパスにおける歯科の役割 歯科診療情報シートの活用について
渡邊 裕; 白井 朋之; 村上 正治; 佐藤 絵美子; 三條 祐介; 酒井 克彦; 枝広 あや子; 蔵本 千夏; 雨宮 智美; 馬場 理奈; 藤平 弘子; 片倉 朗, 日本歯科医師会雑誌, 65, 5, 683, 683, Aug. 2012
(公社)日本歯科医師会, Japanese

口腔がん患者への集学的な精神医学的ケア
村上 正治; 渡邊 裕; 枝広 あや子; 西久保 周一; 佐藤 一道; 山内 智博; 神山 勲; 吉野 文浩; 小板橋 俊哉; 外木 守雄; 山根 源之; 片倉 朗, 歯科学報, 112, 4, 469, 474, Aug. 2012
東京歯科大学学会, Japanese

要介護高齢者口腔関連実態調査報告 特定地域悉皆調査からの知見
森下 志穂; 平野 浩彦; 渡邉 裕; 菅 武雄; 枝広 あや子; 小原 由紀; 佐藤 絵美子, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 23回, 119, 119, Jun. 2012
(一社)日本老年歯科医学会, Japanese

認知症高齢者の口腔機能および嚥下機能実態調査報告 不顕性肺炎発症リスクの視点から
佐藤 絵美子; 平野 浩彦; 渡邊 裕; 枝広 あや子; 小原 由紀; 森下 志穂; 大堀 嘉子; 戸原 玄; 千葉 由美; 新屋 俊明; 山田 律子; 外木 守雄; 片倉 朗; 山根 源之; 鈴木 隆雄, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 23回, 152, 152, Jun. 2012
(一社)日本老年歯科医学会, Japanese

認知症患者の自立摂食を支援するための介入プログラムの考案
枝広 あや子; 平野 浩彦; 山田 律子; 佐藤 絵美子; 冨田 かをり; 中川 量晴; 渡邊 裕; 小原 由紀; 大堀 嘉子; 新谷 浩和; 細野 純, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 23回, 152, 152, Jun. 2012
(一社)日本老年歯科医学会, Japanese

嗅覚低下はアルツハイマー型認知症の人の食行動に影響するか
平野 浩彦; 渡邊 裕; 佐藤 絵美子; 枝広 あや子; 小原 由紀; 森下 志穂, 日本認知症ケア学会誌, 11, 1, 273, 273, Apr. 2012
(一社)日本認知症ケア学会, Japanese

食行動と栄養状態との関係 血管性認知症高齢者を中心に
佐藤 絵美子; 平野 浩彦; 渡邊 裕; 千葉 由美; 枝広 あや子; 片倉 朗, 静脈経腸栄養, 27, 1, 576, 576, Jan. 2012
(株)ジェフコーポレーション, Japanese

介護予防の複合プログラムの効果を特徴づける評価項目の検討 口腔機能向上プログラムの評価項目について
渡邊 裕; 枝広 あや子; 伊藤 加代子; 岩佐 康行; 渡部 芳彦; 平野 浩彦; 福泉 隆喜; 飯田 良平; 戸原 玄; 野原 幹司; 大原 里子; 北原 稔; 吉田 光由; 柏崎 晴彦; 斎藤 京子; 菊谷 武; 植田 耕一郎; 大渕 修一; 田中 弥生; 武井 典子; 那須 郁夫; 外木 守雄; 山根 源之; 片倉 朗, 老年歯科医学, 26, 3, 327, 338, Dec. 2011
(一社)日本老年歯科医学会, Japanese

口蓋部骨髄肉腫より急性骨髄性白血病の診断に至った1例
三條 祐介; 山科 光正; 有坂 岳大; 高田 篤史; 渡邊 裕; 清住 紗代; 奥井 沙織; 藤平 弘子; 外木 守雄; 山根 源之; 宮内 潤; 田中 陽一; 中谷 綾; 岡本 真一郎, 有病者歯科医療, 20, 3, 166, 166, Dec. 2011
(一社)日本有病者歯科医療学会, Japanese

感染症患者における医療面接の重要性の検討
山崎 喜範; 羽田 有沙; 栗山 智宏; 渡邊 裕; 外木 守雄; 山根 源之, 有病者歯科医療, 20, 3, 179, 180, Dec. 2011
(一社)日本有病者歯科医療学会, Japanese

認知症高齢者における摂食・嚥下機能の経年的変化 4年間の追跡調査から
平野 浩彦; 枝広 あや子; 古賀 ゆかり; 高田 靖; 渡邉 裕; 鈴木 隆雄, Dementia Japan, 25, 3, 399, 399, Oct. 2011
(一社)日本認知症学会, Japanese

介護予防における口腔機能向上サービスの推進に関する研究 介護予防における包括サービスの効果について
渡邊 裕; 武井 典子; 植田 耕一郎; 菊谷 武; 福泉 隆喜; 北原 稔; 戸原 玄; 平野 浩彦; 渡部 芳彦; 吉田 光由; 岩佐 康行; 飯田 良平; 柏崎 晴彦; 伊藤 加代子; 野原 幹司; 山根 源之, 老年歯科医学, 26, 2, 102, 104, Sep. 2011
(一社)日本老年歯科医学会, Japanese

アルツハイマー型認知症患者の自立摂食を支援するために 食行動実態調査の結果から
枝広 あや子; 平野 浩彦; 山田 律子; 千葉 由美; 佐藤 絵美子; 渡邊 裕; 小原 由紀; 大堀 嘉子; 菅 武雄; 戸原 玄; 新谷 浩和; 高田 靖; 細野 純; 佐々木 健; 古賀 ゆかり; 那須 郁夫; 山根 源之; 鈴木 隆雄, 老年歯科医学, 26, 2, 97, 98, Sep. 2011
(一社)日本老年歯科医学会, Japanese

認知症高齢者口腔機能の実態調査報告 4年間の追跡調査結果から見えてきたこと
平野 浩彦; 高田 靖; 古賀 ゆかり; 枝広 あや子; 渡邊 裕; 新谷 浩和; 細野 純; 佐藤 絵美子; 佐々木 健; 那須 郁夫; 山根 源之; 鈴木 隆雄, 老年歯科医学, 26, 2, 182, 183, Sep. 2011
(一社)日本老年歯科医学会, Japanese

認知症高齢者の嗅覚機能低下と食行動との関連 アルツハイマー型認知症を中心に
佐藤 絵美子; 平野 浩彦; 渡邊 裕; 新屋 俊明; 戸原 玄; 千葉 由美; 山田 律子; 枝広 あや子; 小原 由紀; 森下 志穂; 大堀 嘉子; 片倉 朗; 山根 源之; 鈴木 隆雄, 老年歯科医学, 26, 2, 184, 185, Sep. 2011
(一社)日本老年歯科医学会, Japanese

高齢者口腔機能評価法としての咬筋触診診査の有効性の検討(第1報) 地域在住高齢者を対象とした調査から
小原 由紀; 平野 浩彦; 枝広 あや子; 佐藤 絵美子; 渡邊 裕; 俣木 志朗; 山根 源之, 老年歯科医学, 26, 2, 199, 200, Sep. 2011
(一社)日本老年歯科医学会, Japanese

口腔機能評価法としての咬筋触診診査の有効性の検討(第2報) 地域高齢者の生活機能・全身機能との関係
小原 由紀; 平野 浩彦; 枝広 あや子; 佐藤 絵美子; 渡邊 裕; 俣木 志朗; 山根 源之, 老年歯科医学, 26, 2, 200, 200, Sep. 2011
(一社)日本老年歯科医学会, Japanese

Dental Hygienist's Role in Regional Alliances NST Part 2 : Shaker Exercise and Recovery of Eating and Swallowing Function
AMEMIYA Tomomi; OHYA Tomoko; BABA Rina; FUJIHIRA Hiroko; SANJYO Yusuke; DOI Mae; ISHIDA Ryo; WATANABE Yutaka; TONOGI Morio; YAMANE Gen-yuki, 齒科學報, 111, 4, 352, 358, 30 Aug. 2011
東京歯科大学学会, Japanese

アルツハイマー型認知症と血管性認知症への食事関連BPSDアセスメント 食行動観察からの分析
枝広 あや子; 平野 浩彦; 山田 律子; 千葉 由美; 佐藤 絵美子; 渡邊 裕; 小原 由紀; 山根 源之; 片倉 朗; 鈴木 隆雄, 日本認知症ケア学会誌, 10, 2, 360, 360, Aug. 2011
(一社)日本認知症ケア学会, Japanese

Clinical study of pediatric injury patients visiting oral and maxillofacial surgery emergency unit
IGETA Kaoruko; NISHIKUBO Shuichi; UKICHI Kenichiro; TAKEYASU Yoshihiro; WATANABE Yutaka; TONOGI Morio; YAMANE Gen-yuki, 齒科學報, 111, 3, 295, 300, 30 Jun. 2011
東京歯科大学学会, Japanese

アルツハイマー型認知症患者の自立摂食を支援するために 食行動実態調査の結果から
枝広 あや子; 平野 浩彦; 山田 律子; 千葉 由美; 佐藤 絵美子; 渡邊 裕; 小原 由紀; 大堀 嘉子; 菅 武雄; 戸原 玄; 新谷 浩和; 高田 靖; 細野 純; 佐々木 健; 古賀 ゆかり; 那須 郁夫; 山根 源之; 鈴木 隆雄, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 22回, 90, 90, Jun. 2011
(一社)日本老年歯科医学会, Japanese

認知症高齢者口腔機能の実態調査報告 4年間の追跡調査結果から見えてきたこと
平野 浩彦; 高田 靖; 大内 ゆかり; 枝広 あや子; 渡邊 裕; 新谷 浩和; 細野 純; 佐藤 絵美子; 佐々木 健; 那須 郁夫; 山根 源之; 鈴木 隆雄, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 22回, 159, 159, Jun. 2011
(一社)日本老年歯科医学会, Japanese

認知症高齢者嗅覚機能は食行動に影響するか アルツハイマー型認知症を中心に
佐藤 絵美子; 平野 浩彦; 渡邊 裕; 戸原 玄; 千葉 由美; 山田 律子; 枝広 あや子; 新屋 俊明; 山根 源之; 鈴木 隆雄, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 22回, 160, 160, Jun. 2011
(一社)日本老年歯科医学会, Japanese

口腔機能評価法としての咬筋触診診査の有効性の検討(第1報) 地域在住高齢者を対象とした調査から
小原 由紀; 平野 浩彦; 枝広 あや子; 佐藤 絵美子; 渡辺 裕; 俣木 志朗; 山根 源之, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 22回, 171, 171, Jun. 2011
(一社)日本老年歯科医学会, Japanese

口腔機能評価法としての咬筋触診診査の有効性の検討(第2報) 地域高齢者の生活機能・全身機能との関係
小原 由紀; 平野 浩彦; 枝広 あや子; 佐藤 絵美子; 渡辺 裕; 俣木 志朗; 山根 源之, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 22回, 171, 171, Jun. 2011
(一社)日本老年歯科医学会, Japanese

アルツハイマー型認知症患者の自立摂食を支援するために 食行動実態調査の結果から
枝広 あや子; 平野 浩彦; 山田 律子; 千葉 由美; 佐藤 絵美子; 渡邊 裕; 小原 由紀; 大堀 嘉子; 菅 武雄; 戸原 玄; 新谷 浩和; 高田 靖; 細野 純; 佐々木 健; 古賀 ゆかり; 那須 郁夫; 山根 源之; 鈴木 隆雄, 日本老年医学会雑誌, 48, Suppl., 125, 125, May 2011
(一社)日本老年医学会, Japanese

【症状・状態別のケアから器具の使い方まで 口腔ケアの困ったを解決】 口腔ケアはなぜ必要?
渡邊裕, ナーシング, 31, 3, 8, 11, 2011
学研メディカル秀潤社, Japanese

【症状・状態別のケアから器具の使い方まで 口腔ケアの困ったを解決】 評価・アセスメント・在宅など 摂食・嚥下機能評価の方法 摂食・嚥下機能を評価するときの舌や義歯の観察方法は?
渡邊裕, ナーシング, 31, 62, 63, 2011

【症状・状態別のケアから器具の使い方まで 口腔ケアの困ったを解決】 評価・アセスメント・在宅など アセスメントシート 口腔ケアのアセスメント票で、「ここだけはみておきたい」という項目は?
渡邊裕, ナーシング, 31, 3, 64, 66, 2011
学研メディカル秀潤社, Japanese

【症状・状態別のケアから器具の使い方まで 口腔ケアの困ったを解決】 評価・アセスメント・在宅など 在宅での口腔ケア 要介護レベルの患者の在宅での口腔ケアのポイントは?
渡邊裕, ナーシング, 31, 68, 69, 2011

認知症高齢者の食行動の特徴 認知症の重症度および原因疾患別の分析
山田 律子; 平野 浩彦; 枝広 あや子; 千葉 由美; 戸原 玄; 佐々木 健; 新谷 浩和; 細野 純; 大堀 嘉子; 渡邊 裕, 日本摂食・嚥下リハビリテーション学会雑誌, 14, 3, 393, 394, Dec. 2010
(一社)日本摂食嚥下リハビリテーション学会, Japanese

認知症高齢者の食行動実態調査(第1報) 認知症重症度別食事関連BPSD発生頻度について
平野 浩彦; 枝広 あや子; 大内 ゆかり; 大堀 嘉子; 菅 武雄; 渡邊 裕; 戸原 玄; 千葉 由美; 新谷 浩和; 高田 靖; 細野 純; 佐々木 健; 山田 律子; 山根 源之, 日本摂食・嚥下リハビリテーション学会雑誌, 14, 3, 394, 395, Dec. 2010
(一社)日本摂食嚥下リハビリテーション学会, Japanese

認知症高齢者の食行動実態調査(第2報) アルツハイマー型認知症と前頭側頭型認知症の特徴
枝広 あや子; 平野 浩彦; 渡邊 裕; 戸原 玄; 新谷 浩和; 高田 靖; 細野 純; 佐々木 健; 山田 律子; 山根 源之, 日本摂食・嚥下リハビリテーション学会雑誌, 14, 3, 395, 395, Dec. 2010
(一社)日本摂食嚥下リハビリテーション学会, Japanese

摂食・嚥下クリニカルパスと脳卒中地域連携パスの効果と展望
矢崎 涼子; 佐藤 絵美子; 羽田 有沙; 三條 祐介; 酒井 克彦; 枝広 あや子; 新 千夏; 渡邊 裕; 山内 智博; 外木 守雄; 山根 源之; 藤平 弘子; 太良木 亜美; 中村 智代子; 新井 健; 片山 正輝; 菅 貞郎; 雨宮 智美, 日本摂食・嚥下リハビリテーション学会雑誌, 14, 3, 594, 595, Dec. 2010
(一社)日本摂食嚥下リハビリテーション学会, Japanese

当院における摂食・嚥下リハビリテーションクリニカルパスの運用と嚥下回診の現状と効果(第2報) 嚥下内視鏡検査を導入して
太良木 亜美; 中村 智代子; 小川 真司; 新井 健; 三條 祐介; 酒井 克彦; 矢崎 涼子; 枝広 あや子; 渡邊 裕; 山根 源之, 日本摂食・嚥下リハビリテーション学会雑誌, 14, 3, 595, 595, Dec. 2010
(一社)日本摂食嚥下リハビリテーション学会, Japanese

多職種連携(チームアプローチ)により在宅復帰可能となった食道癌術後の嚥下障害患者の1例
中村 智代子; 宮本 奈央; 太良木 亜美; 小川 真司; 新井 健; 三條 祐介; 酒井 克彦; 矢崎 涼子; 枝広 あや子; 渡邊 裕, 日本摂食・嚥下リハビリテーション学会雑誌, 14, 3, 597, 597, Dec. 2010
(一社)日本摂食嚥下リハビリテーション学会, Japanese

介護予防における口腔機能向上サービスの推進に関する研究 口腔機能向上サービスの普及・啓発のための研修結果
岩佐 康行; 渡邊 裕; 池主 憲夫; 植田 耕一郎; 菊谷 武; 北原 稔; 戸原 玄; 平野 浩彦; 渡部 芳彦; 有岡 享子; 飯田 良平; 伊藤 加代子; 石田 瞭; 野原 幹司; 小坂 健; 眞木 吉信; 山根 源之, 日本摂食・嚥下リハビリテーション学会雑誌, 14, 3, 476, 477, Dec. 2010
(一社)日本摂食嚥下リハビリテーション学会, Japanese

食行動を認知症の進行から考える どんな行動がいつおこるのか
平野 浩彦; 枝広 あや子; 小原 由紀; 大堀 嘉子; 渡邊 裕; 新谷 浩和; 高田 靖; 佐々木 健; 細野 純; 山田 律子; 鈴木 隆雄, 日本認知症ケア学会誌, 9, 2, 339, 339, Oct. 2010
(一社)日本認知症ケア学会, Japanese

介護予防における口腔機能向上サービスの推進に関する研究(第1報) 平成21年度介護報酬改定の通所事業所への影響
渡邊 裕; 武井 典子; 植田 耕一郎; 菊谷 武; 北原 稔; 戸原 玄; 平野 浩彦; 渡部 芳彦; 有岡 享子; 岩佐 康行; 飯田 良平; 柏崎 晴彦; 伊藤 加代子; 石田 瞭; 野原 幹司; 眞木 吉信; 枝広 あや子; 山根 源之, 老年歯科医学, 25, 2, 199, 200, Sep. 2010
(一社)日本老年歯科医学会, Japanese

認知症・要介護高齢者の口腔機能を中心とした実態調査 地域歯科医師会主催特別養護老人ホーム歯科検診から
山岸 春美; 平野 浩彦; 大内 ゆかり; 藤田 まどか; 枝広 あや子; 渡邊 裕; 高田 靖; 菊谷 武, 老年歯科医学, 25, 2, 206, 207, Sep. 2010
(一社)日本老年歯科医学会, Japanese

認知症高齢者の地域ケア 食事ケアでの歯科支援システムの提案(大田区での取り組みの概要報告)
新谷 浩和; 平野 浩彦; 鈴木 央; 山田 律子; 細野 純; 大堀 嘉子; 竹内 嘉伸; 枝広 あや子; 渡邊 裕; 勝田 優一; 倉治 隆, 老年歯科医学, 25, 2, 244, 245, Sep. 2010
(一社)日本老年歯科医学会, Japanese

認知症高齢者の食行動に関する実態調査報告(第1報) 食事関連BPSD調査票の考案
枝広 あや子; 平野 浩彦; 大内 ゆかり; 渡邊 裕; 戸原 玄; 千葉 由美; 山田 律子; 山根 源之, 老年歯科医学, 25, 2, 257, 258, Sep. 2010
(一社)日本老年歯科医学会, Japanese

認知症高齢者の食行動に関する実態調査報告(第2報) 認知症の原因疾患および重症度の視点から
枝広 あや子; 平野 浩彦; 小原 由紀; 大内 ゆかり; 大堀 嘉子; 菅 武雄; 渡邊 裕; 戸原 玄; 千葉 由美; 新谷 浩和; 高田 靖; 細野 純; 佐々木 健; 那須 郁夫; 山田 律子; 山根 源之; 鈴木 隆雄, 老年歯科医学, 25, 2, 258, 259, Sep. 2010
(一社)日本老年歯科医学会, Japanese

口腔がん患者に対する摂食機能療法の取り組み
高柳 奈見; 土屋 佳織; 雨宮 智美; 大屋 朋子; 多比良 祐子; 清住 沙代; 奥井 沙織; 馬場 里奈; 藤平 弘子; 枝広 あや子; 神山 勲; 佐藤 一道; 渡邊 裕; 山内 智博; 外木 守雄; 山根 源之, 日本歯科衛生学会雑誌, 5, 1, 127, 127, Aug. 2010
日本歯科衛生学会, Japanese

介護予防における口腔機能向上サービスの推進に関する研究 21年度介護報酬改定の都道府県・市への影響
横山 正明; 渡邊 裕; 池主 憲夫; 武井 典子; 相田 潤; 伊藤 加代子; 石田 瞭; 平野 浩彦; 北原 稔; 大原 里子; 眞木 吉信, 口腔衛生学会雑誌, 60, 4, 527, 527, Aug. 2010
(一社)日本口腔衛生学会, Japanese

認知症・要介護高齢者の口腔機能を中心とした実態調査 地域歯科医師会主催特別養護老人ホーム歯科検診から
山岸 春美; 平野 浩彦; 大内 ゆかり; 藤田 まどか; 枝広 あや子; 渡邊 裕; 高田 靖; 菊谷 武, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 21回, 109, 109, Jun. 2010
(一社)日本老年歯科医学会, Japanese

認知症高齢者の食行動に関する実態調査報告(第1報) 食事関連BPSD調査票の考案
枝広 あや子; 平野 浩彦; 大内 ゆかり; 渡邊 裕; 戸原 玄; 千葉 由美; 山田 律子; 山根 源之, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 21回, 144, 144, Jun. 2010
(一社)日本老年歯科医学会, Japanese

認知症高齢者の食行動に関する実態調査報告(第2報) 認知症の背景疾患および重症度の視点から
枝広 あや子; 平野 浩彦; 大内 ゆかり; 大堀 嘉子; 菅 武雄; 渡邊 裕; 戸原 玄; 千葉 由美; 新谷 浩和; 高田 靖; 細野 純; 佐々木 健; 那須 郁夫; 山田 律子; 山根 源之; 鈴木 隆雄, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 21回, 145, 145, Jun. 2010
(一社)日本老年歯科医学会, Japanese

早わかりMEDICAL TOPIC 人工呼吸器関連肺炎(VAP)
渡邊裕, デンタルハイジーン, 30, 1196, 1197, 2010

口腔ケア
渡邊裕, 臨床麻酔, 34, 1009, 1015, 2010

【口腔と健康 口腔機能は健康のバロメーター】 口腔機能の評価法
山根源之; 渡邊裕, Aging & Health, 19, 11, 13, 2010

当院における摂食嚥下リハビリテーションクリニカルパスの運用と嚥下回診の現状と効果
中村 智代子; 太良木 亜美; 小川 真司; 新井 健; 三條 祐介; 矢崎 涼子; 枝広 あや子; 渡邊 裕; 山根 源之, 日本摂食・嚥下リハビリテーション学会雑誌, 13, 3, 369, 369, Dec. 2009
(一社)日本摂食嚥下リハビリテーション学会, Japanese

NSTと摂食・嚥下リハビリテーションを中心に集学的に対応した多系統萎縮症の1例
佐藤 絵美子; 三條 祐介; 矢崎 涼子; 枝広 あや子; 渡邊 裕; 山根 源之; 多比良 祐子; 雨宮 智美; 藤平 弘子, 日本摂食・嚥下リハビリテーション学会雑誌, 13, 3, 473, 473, Dec. 2009
(一社)日本摂食嚥下リハビリテーション学会, Japanese

口腔機能低下に認知症は影響するか 施設入所要介護高齢者の調査から
平野 浩彦; 高田 靖; 細野 純; 那須 郁夫; 佐々木 健; 渡邉 裕; 枝広 あや子; 新谷 浩和; 大堀 嘉子; 島田 裕之, 日本認知症ケア学会誌, 8, 2, 341, 341, Oct. 2009
(一社)日本認知症ケア学会, Japanese

長期入院療養患者に対する口腔ケアの効果 死因に対する口腔ケアの関連性があるか?
高木 幸子; 外木 守雄; 矢崎 涼子; 枝広 あや子; 森下 仁史; 多田 和弘; 潮田 高志; 武安 嘉大; 渡邊 裕; 小澤 靖弘; 山根 源之, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 20回, 112, 112, Jun. 2009
(一社)日本老年歯科医学会, Japanese

口腔がん患者における周術期栄養管理と口腔機能管理指導について
山内 智博; 佐藤 一道; 奥井 沙織; 矢崎 涼子; 枝広 あや子; 花上 伸明; 渡邊 裕; 土井 麻栄; 中濱 孝志; 中本 未央; 末盛 賢司; 佐藤 道夫; 山根 源之, 静脈経腸栄養, 24, 1, 381, 381, Jan. 2009
(株)ジェフコーポレーション, Japanese

当院の地域連携NST活動について
渡邊 裕; 枝広 あや子; 矢崎 涼子; 花上 伸明; 山内 智博; 土井 麻栄; 中濱 孝志; 中本 未央; 末盛 賢司; 佐藤 道夫, 静脈経腸栄養, 24, 1, 471, 471, Jan. 2009
(株)ジェフコーポレーション, Japanese

高齢者医療における歯科医科連携、病院内の歯科医科連携をスムーズに行う
渡邊裕, Geriatric Medicine, 47, 1569, 1574, 2009

【癌患者における栄養ケアの実際】 頭頸部癌患者の栄養ケアの実際
花上伸明; 矢崎涼子; 枝広あや子; 中本未央; 土井麻栄; 近藤秀士; 中濱孝志; 渡邊裕; 山内智博; 市ノ川義美; 山根源之, 栄養-評価と治療, 26, 224, 228, 2009

【超高齢時代の歯科臨床のあり方 地域連携と予後を想定した治療計画】 疾患を考慮した歯科治療計画
渡邊裕, 日本歯科評論, 69, 11, 61, 70, 2009
ヒョーロン・パブリッシャーズ, Japanese

当院における口腔ケアおよび摂食・嚥下機能評価依頼患者に関する検討
渡邊 裕; 三條 祐介; 矢崎 涼子; 枝広 あや子; 花上 伸明; 蔵本 千夏; 山内 智博; 森本 光明; 外木 守雄; 山根 源之; 藤平 弘子, 老年歯科医学, 23, 2, 164, 164, Sep. 2008
(一社)日本老年歯科医学会, Japanese

高濃度流動食(テルミール2.0α)の有用性の検討
渡邊 裕; 森谷 有紀子; 矢崎 涼子; 枝広 あや子; 花上 伸明; 山内 智博; 山根 源之; 土井 麻栄; 鷲尾 美枝; 中濱 孝志; 中本 未央; 末盛 賢司; 田中 葉子, 静脈経腸栄養, 23, 増刊, 233, 233, Jan. 2008
(株)ジェフコーポレーション, Japanese

当院における摂食・嚥下リハビリテーションクリニカルパスの効果
枝広 あや子; 矢崎 涼子; 花上 伸明; 渡邊 裕; 山内 智弘; 山根 源之; 土井 麻栄; 中濱 孝志; 中本 未央; 末盛 賢司; 田中 葉子, 静脈経腸栄養, 23, 増刊, 236, 236, Jan. 2008
(株)ジェフコーポレーション, Japanese

当院口腔がんセンターで用いている摂食・嚥下指導パンフレットについて
矢崎 涼子; 枝広 あや子; 花上 伸明; 渡邊 裕; 岡崎 雄一郎; 山内 智博; 山根 源之, 静脈経腸栄養, 23, 増刊, 329, 329, Jan. 2008
(株)ジェフコーポレーション, Japanese

ソフト食導入による術後食形態6段階から4段階への整理に対する取り組み
中濱 孝志; 鷲尾 美枝; 土井 麻栄; 間部 克善; 田中 葉子; 佐藤 道夫; 安藤 暢敏; 山内 智博; 渡邊 裕; 花上 伸明; 矢崎 涼子; 枝広 あや子; 山根 源之; 中本 未央; 末盛 賢司, 静脈経腸栄養, 23, 増刊, 338, 338, Jan. 2008
(株)ジェフコーポレーション, Japanese

【医療連携による在宅歯科医療 新しい医療提供体制に歯科はどう関わるか】 制度改革をリードする実践例から NST(栄養サポートチーム)とOST(口腔保健サポートチーム) 地域連携NSTにおける歯科の役割
山根源之; 渡邊裕, 日本歯科評論, 別冊, 204, 207, 2008

摂食・嚥下障害患者に対する院内クリニカルパスの効果
枝広 あや子; 藤平 弘子; 潮田 高志; 花上 伸明; 渡邊 裕; 外木 守雄; 山根 源之, 老年歯科医学, 22, 2, 161, 162, Sep. 2007
(一社)日本老年歯科医学会, Japanese

左中大脳動脈領域の脳血管障害患者への摂食・嚥下リハビリテーションの経験
黒川 貴史; 枝広 あや子; 花上 伸明; 佐藤 一道; 渡邊 裕; 外木 守雄; 山根 源之; 菅 貞郎; 高橋 正憲, 歯科学報, 107, 2, 230, 230, Apr. 2007
東京歯科大学学会, Japanese

総合病院「集中治療室」における歯科衛生士学生の臨床実習について
永井由美子; 白鳥たかみ; 多田美穂子; 藤平弘子; 馬場里奈; 前田愛; 高柳奈見; 清住沙代; 鈴木貴子; 奥井沙織; 杉山節子; 渡邊裕; 山根源之; 下野正基, 日本歯科衛生学会雑誌, 2, 1, 248, 249, 2007

高齢者の口腔ケア
山根源之; 渡邊裕; 外木守雄, 日本老年医学会雑誌, 44, 1, 1, 10, 2007

口腔ケアスクリーニングシートの開発 急性期病院におけるスクリーニング
渡邊 裕; 枝広 あや子; 藤平 弘子; 蔵本 千夏; 外木 守雄; 山根 源之, 老年歯科医学, 21, 3, 214, 214, Dec. 2006
(一社)日本老年歯科医学会, Japanese

摂食・嚥下障害患者への対応に関するNST(Nutrition Support Team)の効果について
枝広 あや子; 藤平 弘子; 佐藤 一道; 渡邊 裕; 外木 守雄; 山根 源之, 老年歯科医学, 21, 3, 284, 284, Dec. 2006
(一社)日本老年歯科医学会, Japanese

高齢者の睡眠時呼吸障害
佐藤 一道; 有坂 岳大; 森下 仁史; 塚本 裕介; 枝広 あや子; 渡邊 裕; 外木 守雄; 山根 源之, 老年歯科医学, 21, 3, 288, 289, Dec. 2006
(一社)日本老年歯科医学会, Japanese

重度な骨量不足症例におけるインプラント治療のメインテナンスについて
馬場里奈; 祢宜佑梨江; 清住沙代; 高柳奈見; 奥井沙織; 前田愛; 伊多波怜子; 藤平弘子; 花上伸明; 佐藤一道; 高田篤史; 岡崎雄一郎; 渡邊裕; 蔵本千夏; 木津康博; 山内智博; 小澤靖弘; 森本光明; 外木守雄; 山根源之, 日本歯科衛生学会雑誌, 1, 1, 42, 43, 2006

効果的な口腔ケアの実践 口腔内環境の整備とケアのポイント
外木守雄; 渡邊裕; 山根源之; 馬場里奈; 藤平弘子, Expert Nurse, 22, 7, 18, 21, 2006
照林社, Japanese

介護保健施設における口腔機能評価に関する研究(第1報) 食事と口腔機能の関係
渡邊 裕; 蔵本 千夏; 外木 守雄; 山根 源之; 石井 拓男; 岡田 眞人; 今村 嘉宣; 大川 由一; 山田 善裕; 新庄 文明; 宮武 光吉, 老年歯科医学, 20, 3, 238, 239, Dec. 2005
(一社)日本老年歯科医学会, Japanese

介護保険施設における口腔機能評価に関する研究(第2報) 施設種別の比較
石井 拓男; 渡邊 裕; 蔵本 千夏; 山根 源之; 岡田 眞人; 今村 嘉宣; 大川 由一; 山田 善裕; 新庄 文明; 宮武 光吉, 口腔衛生学会雑誌, 55, 4, 487, 487, Aug. 2005
(一社)日本口腔衛生学会, Japanese

顎顔面インプラント治療におけるインターディシプリナリー・アプローチ
岩崎 美和; 高柳 奈見; 奥井 沙織; 合原 愛; 伊多波 怜子; 馬場 里奈; 藤平 弘子; 大西 雄英; 花上 伸明; 佐藤 一道; 高田 篤史; 岡崎 雄一郎; 渡邊 裕; 蔵本 千夏; 木津 康博; 小澤 靖弘; 森本 光明; 外木 守雄; 山根 源之, 齒科學報, 105, 3, 259, 259, 30 Jun. 2005
Japanese

介護保健施設における口腔ケアに関する研究(第2報) 口腔ケアの現状と歯科医療との関係
渡邊 裕; 蔵本 千夏; 山根 源之; 石井 拓男; 岡田 眞人; 今村 嘉宣; 大川 由一; 山田 善裕; 新庄 文明; 宮武 光吉, 老年歯科医学, 19, 3, 231, 232, Dec. 2004
(一社)日本老年歯科医学会, Japanese

介護保険施設における口腔ケアに関する研究 : 口腔ケアの実施状況と歯科受療状況について
大川 由一; 岡田 眞人; 山田 善裕; 渡邊 裕; 蔵本 千夏; 新庄 文明; 山根 源之; 宮武 光吉; 石井 拓男, 口腔衛生学会雑誌 = JOURNAL OF DENTAL HEALTH, 54, 4, 331, 331, 30 Aug. 2004
Japanese

要介護老人の摂食障害発生要因に関する研究(第3報) とくに脳血管障害入院患者の口腔内についての実態調査
今村 嘉宣; 石井 拓男; 岡田 真人; 宮武 光吉; 山根 源之; 渡邊 裕; 大川 由一; 佐藤 裕二, 老年歯科医学, 18, 3, 239, 240, Dec. 2003
(一社)日本老年歯科医学会, Japanese

Neuromagnetic Analysis of Hand Precision Movement Using Magnetoencephalography (MEG)(Abstracts of Workshop in the ORAL HEALTH SCIENCE CENTER)
Takahashi M; Haraguchi T; Watanabe Y, The bulletin of Tokyo Dental College, 44, 2, 81, 83, May 2003
Tokyo Dental College, English

3A06 手の巧緻運動(precision movement)のMEGによる検討
高橋 正憲; 原口 孝之; 渡邊 裕, 齒科學報, 103, 1, 28, 29, 30 Jan. 2003
Japanese

食事療法 変化することを信じて Eメールでの遠隔摂食指導
村松美奈; 沼田正廣; 村田篤司; 花上伸明; 渡邊裕; 山根源之; 本橋佳子; 内山健志; 一戸達也, 難病と在宅ケア, 9, 1, 27, 30, 2003
日本プランニングセンター, Japanese

顎変形症患者の術後評価 : 第1報 アンケート調査について
大塚 裕; 有坂 岳大; 内田 淳; 原口 孝之; 森崎 重規; 渡邊 裕; 小澤 靖弘; 外木 守雄; 山根 源之, 齒科學報, 102, 10, 819, 819, 30 Oct. 2002
Japanese

口腔粘膜病変および口腔関連疾患の診断
福島 大平; 渡邊 裕; 小澤 靖弘; 森本 光明; 外木 守雄; 山根 源之; 高橋 慎一; 田中 陽一, 齒科學報, 100, 2, 55, 55, 29 Feb. 2000
Japanese

口腔粘膜病変及び口腔関連疾患の診断 口腔疾患と掌蹠膿疱症3
森本光明; 渡邊裕; 小澤靖弘; 福島大平; 外木守雄; 山根源之; 高橋慎一; 高橋正憲; 中島庸也; 田中陽一, 歯科学報, 100, 6, 519, 521, 2000

口腔粘膜病変及び口腔関連疾患の診断 口腔疾患と掌蹠膿疱症(2)
歯科学報, 森本光明, 渡邊裕, 小沢靖弘, 福島大平, 外木守雄, 山根源之, 高橋慎一, 高橋正憲, 中島庸也, 田中陽一, 100, 5, 431, 433, 2000

口腔粘膜病変及び口腔関連疾患の診断 類天疱瘡
福島大平; 渡邊裕; 小澤靖弘; 森本光明; 外木守雄; 山根源之; 高橋慎一; 田中陽一, 歯科学報, 100, 3, 241, 243, 2000

口腔粘膜病変及び口腔関連疾患の診断 口腔疾患と掌蹠膿疱症1
森本光明; 渡邊裕; 小澤靖弘; 福島大平; 外木守雄; 山根源之; 高橋慎一; 高橋正憲; 中島庸也; 田中陽一, 歯科学報, 100, 4, 333, 336, 2000

口腔粘膜病変及び口腔関連疾患の診断 天疱瘡
福島大平; 渡邊裕; 小澤靖弘; 森本光明; 外木守雄; 山根源之; 高橋慎一; 田中陽一, 歯科学報, 100, 2, 165, 167, 2000

【智歯を抜くとき,活かすとき-歯列の中で智歯をどう評価するのか】 老年者と智歯
渡邊裕; 山根源之, 日本歯科評論, 688, 125, 133, 2000
ヒョーロン・パブリッシャーズ, Japanese

Clinical Investigation of Mental Nerve Sensory Testing after SSRO : First Report on the Testing Method using the SW Pressure Aesthesiometer
TAKASAKI YOSHITO; NOMA HIROYASU; FUJIKAWA MAKI; TAKAKI TAKASHI; SHIMIZU HIDETAKA; KYOUMOTO HIROYUKI; MORI YOSHIHIDE; NOGUCHI NOBUHIRO; GOTO MASA-AKI; KATSUKI TAKESHI; WATANABE YUTAKA; TONOGI MORIO; YAMANE GEN-YUKI, Jpn. J. Jaw Deform, 10, 3, 290, 299, 2000
Japanese

口腔粘膜病及び口腔関連疾患の診断 口腔粘膜疾患の視診型(悪性病変)
小沢靖弘; 山根源之; 外木守雄; 福島大平; 森本光明; 渡邊裕; 田中陽一, 歯科学報, 99, 12, 1113, 1115, 1999
Japanese

口腔粘膜病変及び口腔関連疾患の診断 口腔粘膜疾患の視診型(良性病変)
小沢靖弘; 山根源之; 外木守雄; 森本光明; 福島大平; 渡邊裕; 田中陽一, 歯科学報, 99, 11, 977, 979, 1999
Japanese

口腔粘膜病変及び口腔関連疾患の診断 口腔粘膜病変の色素診査法
渡邊裕; 小沢靖弘; 福島大平; 森本光明; 外木守雄; 山根源之; 田中陽一, 歯科学報, 99, 10, 815, 817, 1999
Japanese

口腔粘膜病変及び口腔関連疾患の診断 口腔粘膜病変の色素診査法
渡邊裕; 小沢靖弘; 福島大平; 森本光明; 外木守雄; 山根源之; 田中陽一, 歯科学報, 99, 8, 669, 671, 1999
Japanese

口腔粘膜病変および口腔関連疾患の診断 口腔粘膜病変の色素診査法
山根源之; 外木守雄; 森本光明; 福島大平; 小沢靖弘; 渡邊裕; 田中陽一, 歯科学報, 99, 7, 557, 559, 1999
Japanese

口腔粘膜病変及び口腔関連疾患の診断 口腔粘膜病変の色素診査法
渡邊裕; 小沢靖弘; 福島大平; 森本光明; 外木守雄; 山根源之; 田中陽一, 歯科学報, 99, 9, 721, 723

Wisdom tooth in elderly
Dental Review, 688, 125, 133

健康寿命延伸に寄与する老年歯科医療 : 多職種との連携をふまえて
櫻井, 薫(歯学); 栂安, 秀樹; 青木, 利美; 池邉, 一典; 金崎, 伸幸; 佐藤, 裕二(歯学); 八田, 昂大; 渡邊, 裕(歯学)
松風, 2018, v, 151p, Japanese

オーラルフレイルQ&A : 口からはじまる健康長寿
平野, 浩彦; 飯島, 勝矢; 渡邊, 裕(歯学)
医学情報社, Nov. 2017, 9784903553696, 41p, Japanese

口腔ケアの疑問解決Q&A : 評価・アセスメントから病態にあわせたアプローチまで
渡邊, 裕(歯学)
学研メディカル秀潤社,学研マーケティング (発売), 2013, 9784780911176, 183p, Japanese

実践！介護予防 口腔機能向上マニュアル
財団法人 東京都高齢者研究・福祉振興財団, 2010

医師・歯科医師のための口腔診療必携 困ったときのマニュアル・ヒント集
金原出版, 2010

口腔機能維持管理マニュアル
口腔保健協会, 2010

【熟練医から"日常診療のさまざまなコツ"を伝授】 "医療面接/診察/患者とのコミュニケーション"のコツ（日本プライマリ・ケア学会編集）治療:91巻臨増
南山堂, 2009

歯学生のための摂食・嚥下リハビリテーション学
医歯薬出版, 2008

老年医学update 2008-09
メジカルビュー社, 2008

高齢者の口腔機能管理-高齢者の心身の特性を踏まえた在宅歯科医療を進めるためには-
社団法人日本歯科医師会 日本歯科総合研究機構, 2008

日本老年歯科医学会監修 口腔ケアガイドブック
口腔保健協会, 2008

病気とくすりハンドブック
医歯薬出版, 2008

基礎から学ぶ口腔ケア
Gakken, 2007

咀嚼の辞典
朝倉書店, 2007

歯科関係者に必要な介護の知識 訪問診療をすすめるために
口腔保健協会, 2006

摂食・嚥下障害を理解するための解剖と機能
平成１６年度日本歯科医師会生涯研修ライブラリー, 2005

デンチャーが上手くなりたい早く名医と呼ばれたい－解剖学的視点で作る印象と総義歯－
株式会社ジーシー, 2005

摂食・嚥下のメカニズム 分担（臨床および検査）
医歯薬出版, 2003

公衆衛生看護疫学演習, 2024年, 修士課程, 保健科学院

口腔健康科学実習Ⅳ, 2024年, 博士後期課程, 歯学院

高齢者口腔健康管理学研究Ⅱ, 2024年, 博士後期課程, 歯学院

口腔健康科学実習Ⅲ, 2024年, 博士後期課程, 歯学院

口腔健康科学実習Ⅱ, 2024年, 博士後期課程, 歯学院

口腔健康科学実習Ⅰ, 2024年, 博士後期課程, 歯学院

口腔健康科学実習Ⅴ, 2024年, 博士後期課程, 歯学院

加齢歯科学, 2024年, 博士後期課程, 歯学院

高齢者口腔健康管理学, 2024年, 博士後期課程, 歯学院

高齢者口腔健康管理学研究Ⅰ, 2024年, 博士後期課程, 歯学院

保健生理学, 2024年, 学士課程, 医学部

健康と社会, 2024年, 学士課程, 全学教育

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高齢者歯科学, 2024年, 学士課程, 歯学部

高齢者歯科学臨床実習Ⅰ, 2024年, 学士課程, 歯学部

高齢者歯科学臨床実習Ⅱ, 2024年, 学士課程, 歯学部

Verification of the effect of oral frailty countermeasures on healthy life expectancy through collaboration between medical care, health, and nursing care prevention
Grants-in-Aid for Scientific Research
01 Apr. 2025 - 31 Mar. 2030
渡邊 裕; 飯島 勝矢; 平野 浩彦; 白部 麻樹; 池邉 一典; 岩崎 正則
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 25K02834

超音波エコーを用いた口腔機能発達不全の早期発見方法の確立
科学研究費助成事業
Apr. 2024 - Mar. 2027
弘中 祥司; 渡邉裕; 佐藤秀夫; 石崎晶子; 林佐智代
日本学術振興会, 基盤研究(C), 昭和大学, 24K13248

認知症高齢者における口腔セルフケアの質の低下の検出方法の開発と介入効果の検討
科学研究費助成事業
01 Apr. 2023 - 31 Mar. 2026
釘宮 嘉浩; 五十嵐 憲太郎; 古屋 純一; 村上 正治; 中村 純也; 渡邊 裕; 枝広 あや子
日本学術振興会, 基盤研究(C), 国立研究開発法人国立長寿医療研究センター, 23K09497

Development and effect verification of intervention programs according to whole body, swallowing, and nutritional status of patients with severe heart disease
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2022 - 31 Mar. 2026
千葉 由美; 戸原 玄; 野原 幹司; 渡邊 裕; 三枝 祐輔; 内海 桃絵; 石上 友章; 佐々木 康之輔; 吉田 俊子; 二藤 隆春; 山田 律子; 大橋 伸英
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Yokohama City University, 22H03390

高齢者の保健事業と介護予防の一体的実施の推進及び効果検証のための研究
厚生労働行政推進調査事業費補助金 政策科学総合研究事業（政策科学推進研究事業）
Apr. 2023 - Mar. 2026
津下 一代; 飯島 勝矢; 渡邊 裕; 田中 和美; 樺山 舞; 斎藤 民; 平田 匠
厚生労働省, 女子栄養大学, 20AA2006

A Study on Integrated Implementation of Health Service and Preventive Long-Term Care Service for the Elderly Regarding Oral Frailty
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2020 - 31 Mar. 2025
渡邊 裕; 飯島 勝矢; 小原 由紀; 平野 浩彦; 池邉 一典; 岩崎 正則
①オーラルフレイルの有病率と低栄養、要介護等の発生要因に関する調査
2021年度は2020年度に行われた口腔機能に関連する大規模長期コホート研究（板橋）、後期高齢者歯科健診（神奈川県、鳥取県）のデータを2018年、2019年のデータと統合した。2021年度は草津、高島平の調査と、介入研究（岩見沢）はCOVID-19のため実施できなかった。2018年から2020年までに実施された、板橋、草津、高島平、柏の統合データを用いて、地域在住の日本人高齢者5,083人の舌圧の年齢別および性別別の人口基準値を算出した。結果、男女ともに、高齢になるほど舌圧は有意に減少した。年齢と性別の相互作用は、舌圧に有意な影響を及ぼしていることが明らかになった。これについては論文化し公開した。オーラルフレイルと医療費との関連については、2190名の後期高齢者歯科検診のデータと国保データベースを統合し分析した。結果、オーラルフレイルは医科の年間外来医療費が高額であることと有意な関連を認めた。同様に歯科の年間外来医療費とオーラルフレイルにも有意な関連を認めた。オーラルフレイルの各検査項目と医療費との関連については，客観的咀嚼能力の低下と医科の年間外来医療費が高額であることと有意な関連を認めた。
②地域包括ケアシステムにおける住民主体の通いの場と歯科診療所との共同によるオーラルフレイル予防のための地域介入研究、③オーラルフレイル改善プログラムの効果検証
令和２年度と同様に海老名市では歯科診療所において、岩見沢市では通いの場においてオーラルフレイル改善プログラムを実施する予定であったが、岩見沢市では通いの場がCOVID-19によって自粛となり、自宅でのセルフプログラムでの実施となった。海老名市では予定通りオーラルフレイル改善プログラムを実施し、効果について国保データベースと統合し分析している。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 20H03899

Regional Intervention Study on Oral Function Improvement and Nutrition Improvement Program at the Place of Commuting
Grants-in-Aid for Scientific Research
Apr. 2020 - Mar. 2025
山崎 裕; 渡邊 裕; 本川 佳子; 玉腰 暁子; 小笠原 克彦
本研究事業の主体となる「げんき発見ドック」において令和4年8、9月および令和5年9月にベースライン調査（参加者合計180名）、令和5年2月および令和6年2月に介入後調査（参加者合計128名）を実施した。データ欠損のあった4名を除いた124名の口腔機能向上・栄養改善プログラムによる改善効果を検討したところ、オーラルフレイルの判定項目の該当数に関して、32名（25.0％）が改善し、67名（52.3％）が維持、29名（22.7％）が悪化した。以上の結果から口腔機能向上・栄養改善プログラムによる改善効果が期待された。
昨年度高齢者の口腔細菌叢において着目した関節リウマチなどとの関連が報告されているPrevotella属とオーラルフレイルの関連については、令和2年げんき発見ドック参加者208名を対象にプレボテラ属の口腔細菌叢に占める割合に関して3群に分類し，オーラルフレイルと各項目との関連を順序ロジスティック回帰分析で検討した．結果3群間とOF の各判定項目では，OF該当項目数(OR:1.48,95%CI:1.14-1.92) ，OF該当者(OR:4.20,95%CI:1.52-11.58)で有意な関連が認められた．本研究結果は，口腔機能低下の検査及び管理が，高齢者の口腔内細菌叢の悪化予防，全身の健康の維持改善に貢献する可能性を示唆した．歯科衛生士、管理栄養士による口腔機能向上・栄養改善プログラムと食事栄養指導については、自宅でのセルフプログラムと郵送によるプログラム実施状況の確認とフィードバックを継続し、令和2年度および令和4年度、令和5年度参加者の介入前後の比較分析を行っている。以上の結果を踏まえ、口腔機能向上・栄養改善プログラム、食事栄養指導のマニュアルの改訂を行った。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 23K20331

Establishment of evaluation method of oral function standard of children using ultrasonic echo system
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2019 - 31 Mar. 2022
弘中 祥司; 石崎 晶子; 村田 尚道; 渡邊 裕; 三田村 佐智代; 佐藤 秀夫
平成30年度より保険導入された口腔機能発達不全症とは、器質的に異常はないが口腔機能の獲得が遅延している状態のことであるが、診断は主に問診と視診によって行われており、検査方法や治療方法が確立されていない。本研究では、幼児に対して口腔周囲のみならず，様々な測定を行うことで口腔機能発達不全に影響を及ぼす因子を特定し、今後の診断と治療方法の確立に役立てていくことを目的とした．
本研究の対象児は,コロナ蔓延前の区立保育園に通っている96名(男児42名,女児54名,年齢：3～6歳)である.今年度は，コロナにより，保育園での調査が不可能であった．
前年までの保護者へのアンケート調査からは,対象児の年齢,性別,成長履歴,家庭環境,生活習慣,口腔習癖,発音,運動習慣,鼻疾患,および食事行動に関するデータを収集した.加えて,下腿周囲長,握力,舌圧,咬合力,口唇閉鎖力,うがいテスト,構音検査,口腔内診査を行った.（昭和大学倫理委員会承認番号：2018-007）
アンケート調査において口腔機能発達不全症あり群は,なし群と比較して,食行動の問題と鼻疾患の有無において,「はい」と回答した人の割合が有意に多かった.機能面では舌圧の値は口腔機能発達不全症あり群の方がなし群と比較して有意に低かった.その他の調査項目に関しては,口腔機能発達不全症あり群となし群で有意な差は認められなかった.
本研究結果より,幼児の口腔機能発達不全に影響を及ぼす因子は舌圧と鼻疾患の有無,食行動であることが示唆された.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Showa University, 19K10453

Development and Evaluation of Rehabilitation Program depending on Patients with Severe Body and Dysphagic Conditions
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2017 - 31 Mar. 2022
千葉 由美; 市村 久美子; 戸原 玄; 中山 渕利; 野原 幹司; 渡邊 裕; 三枝 祐輔; 石上 友章; 二藤 隆春; 山田 律子; 大橋 伸英; 峯岸 慎太郎
重症患者（循環器系疾患を有する患者）を対象とした摂食嚥下機能に応じたプログラム作成に際し、調査項目に関する有効な英語論文は昨年の検索分に加え、本年度アップデート分を含めても十分とはいえない状況である。本プロジェクトの研究遂行内容に関する有識者による具体的な話し合いを踏まえ、より質の高い臨床実践プログラム作成に向けて、第一段階のプレ調査（後ろ向き調査）、ならびに調査の不足項目の把握と必要項目の選定を臨床的な視点から行うことが重要であることが確認された。循環器系（外科、内科）の有識者や先進的医療を提供している高度実践者から情報を得ることが必要と考えた。そこで、心臓・肺移植術の提供実績のある米国の急性期病院における胸部外科（心臓・肺）の手術患者を対象とした周手術期管理、摂食嚥下障害に関する実践・医療体制等を視察した。その結果、高度技術を要する手術患者に対しては、全身管理、ならびに肺移植といった誤嚥による移植肺へのダメージに直接影響するリスクを防止するために、患者の全身状態のモニタリングや病院の基準にそった術前、術後の摂食嚥下のリスク評価を行っていた。摂食嚥下のリスク評価や誤嚥予防の具体的内容については、日本でも実施されている一般的な摂食嚥下評価と同様であったが、患者の疾患によって手術後の適応する検査内容は異なっていた。また、手術カンファレンスには、医師や上級看護師であるNP（Nurse Practitioner）をはじめとする多職種が参加し、円滑なチーム医療の体制整備がされていた。これらの知見をもとに、調査項目の精選、ならびに調査準備を進めることが重要と考えた。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Yokohama City University, 17H04458

Educational effectiveness and improved management of oral function using an oral care support application for ventilator patients.
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Apr. 2018 - Mar. 2022
田戸 朝美; 山勢 博彰; 山本 小奈実; 佐伯 京子; 渡邊 裕
本研究の目的は、人工呼吸器患者の合併症である人工呼吸器関連肺炎（Ventilator- Associated Pneumonia: VAP）と抜管時の誤嚥性肺炎を予防するタブレット型PCに搭載したアプリケーションによる支援ツール（口腔ケア支援アプリ）を開発し教育を行うことで、看護師の口腔ケア技術と口腔機能管理能力が向上するかを明らかにすることである。口腔ケア支援アプリは、口腔ケアの実施のみならず医療チームの活用を含め実践を支援し、挿管から抜管までの人工呼吸管理中の全期間継続的に口腔機能管理を看護師が行うことを支援するツールである。
本年度は、口腔ケア支援アプリの開発を行うために、人工呼吸器患者の口腔ケアの実際と教育について調査する計画とした。その調査準備として、人工呼吸器患者の口腔ケアに関する文献検討を実施した。2017年にAmerican Association of critical-care nursesよりケアカリキュラムが提示されており、海外の動向も踏まえ調査項目を検討した。また、2012年に周術期口腔機能管理が保険適用になり、周術期に口腔衛生状態を整え、術後もケアを受けることが推進されたことを踏まえ、歯科医師をはじめとする歯科衛生チームとの関わりも調査項目に含めることとした。その他、人工呼吸器患者の口腔ケアの実際と教育の内容を明らかにするために、調査項目を研究者間で検討した。
文献検討の結果、調査項目を、口腔ケアの目的、方法、実施者、実施間隔、教育方法及び歯科衛生チームや呼吸ケアチームなどとのかかわりとした。対象者は、人工呼吸器患者の管理において多職種からなる専門性の高いチーム医療を提供している呼吸ケアチームのメンバーを選出した。また集中治療室で口腔ケアの教育を主導的に行っている看護師・医師・歯科医師も対象とすることとした。来年度に調査を実施する予定である。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Yamaguchi University, 18K10272

Effectiveness of prevention strategy for combined frailty
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
01 Apr. 2017 - 31 Mar. 2020
Kim Hunkyung
The prevalence of multiple frailty was 15.4%. Subjects with multiple frailty had significantly reduced MMSE score, grip strength, and usual walking speed; and higher GDS score, history of chronic disease such as heart disease, diabetes, osteoporosis, anemia, knee pain, urinary incontinence, and falls. Higher GDS score, not exercise habit, and having chronic diseases were significantly associated with multiple frailty, whereas greater MMSE score, knee extension strength, number of teeth, and usual walking speed had protective effects.
A total of 88 multiple frailty, elderly women over 65 years were randomly assigned to one of three groups: muscle strengthen exercise (M-Ex), cognitive stimulate exercise (C-Ex), and combined M-Ex and C-Ex group. The exercise group attended a 60-minute training program twice a week for three months. Significant group × time interactions were observed for grip strength (F-value= 5.589, P=0.006) and usual walking speed (F-value=9.343, P<0.001).
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 17H02187

Establishment of tne method to improve dementia patients with problem feeding behaviors by mirror neuron system
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2016 - 31 Mar. 2019
Watanabe Yutaka; KUGIMIYA Yoshihiro; SAKAMOTO Mayumi; SUMA Shino; MIKAMI Yurie
The purpose of this study is to get knowledge that contributes to the prevention and improvement of problem feeding behaviors associated with dementia. Therefore, we investigated the situation of orphans and problem feeding behaviors of dementia patients, the factors affecting them over time, and examined the relationship with the state of dementia etc.
As the results, we found that there is a significant association between cognitive decline and anorexia, depression, food interruption, ADL, number of comorbidities, and presence or absence of antidementia and psychotropic drugs. In addition to clarifying the relationship between mild cognitive impairment and dysphagia, we found that oral function and oral hygiene management could improve cognitive function. And, it was revealed that cognitive function, appetite, and Self-feeding ability decline were significantly associated with the occurrence of death.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 16K11908

Elucidation of eating behavior-related disorders of dementia patients by the mirror neurons
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
01 Apr. 2013 - 31 Mar. 2016
Watanabe Yutaka; SUMA Sino
The purpose of this study is to examine the factor to eating behavior-related disorders associated with dementia. Therefore, we have investigated the factors that related to eating alone and the eating behavior-related disorder in 2522 patients who are attending dementia disease center. At first, we analyzed factors that related to the loss of appetite for eating behavior-related disorders according to disease type of dementia. Secondly, we investigated the anatomic change of the brain, the mirror neuron and the brain function associated with cognitive function of the people with mild cognitive impairment by various brain function measurement devices. In addition, the program that limit the eating alone and activate the mirror neuron system on the swallowing movement to the people with mild cognitive impairment, was investigated for the possibility of suppressing the eating behavior-related disorders.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), National Center for Geriatrics and Gerontology, 25463282

The mirror neuron improve dysphagia? : Evaluation by the multi modality for functional brain imaging
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
2008 - 2010
WATANABE Yutaka; SANJYO Yusuke; USHIODA Takashi; EDAHIRO Ayako
Purpose : Mirror neurons fire when a particular action is performed and when the animal observes the same action being performed by another individual. We have demonstrated the activity of mirror neurons during swallowing-related visual stimulation, and investigated the establishment of a new form of rehabilitation. In addition, to examine clinical application of this new rehabilitation, we examined fact-finding about an obstacle of the dietary behavior of the Alzheimer's disease (AD) patients whom conventional rehabilitation had difficulty with.
Methods : Subjects were 15 healthy individuals. Brain activity during the presentation of swallowing movements was measured using 3T-fMRI and MEG. The experimental method consisted of showing 16 types of stimulus video to subjects, comprising general videos and fluoroscopic videos. In MEG study, swallowing-related stimuli comprised an animated image of the left profile of a person swallowing water with laryngeal elevation as a visual swallowing trigger stimulus, and a swallowing sound as an auditory swallowing trigger stimulus. We measured the brain signal by 3T-fMRI and MEG and analyzed.
In fact-finding survey of the diet behavior of the AD patients, The enrolled AD patients, totaled 150 patients, who were residents of institutions or group homes. The patients underwent an eating behavior examination, cognitive assessment, neurological examination, and vital function tests. The eating behavior examination consisted of observation of the patients at mealtime. Items assessed eating behavior included the number of feeding cycles, stopping of eating or agitation, and dysfunction.
Results : Activity in mirror neuron areas was observed during water swallowing, fluoroscopic video. Activity in mirror neuron areas was left-hemisphere-dominant during the presentation of WXL and right-hemisphere-dominant during the presentation of CXL. With animation stimuli (animation stimulus, animation+swallowing sound stimuli, animation+artificial sound stimuli), activation in mirror neuron areas, corresponding to mirror neurons, was observed between 620 and 720 ms before the trigger.
In fact-finding survey of the diet behavior of the AD patients, Logistic regression analysis performed to identify factors with a significant affect on decreased independence in eating were difficulty in beginning a meal, presence of dysphagia signs, and the severity of dementia.
Conclusion : Evaluation by the multi modality for functional brain imaging, I accepted activity in the mirror neuron of the deglutition. In addition, that it was necessary to promote adjustment of the meal environment that promoted a meal start to maintain an independence feeding and a meal start was suggested by fact-finding of the dietary behavior of the AD patient. The possibility that could improve a problem of the appetite of the AD patients that it had been assumed that I was difficult till now by performing the appetite support that I used a mirror neuron system for was suggested by this.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Tokyo Dental College, 20592469

視覚・聴覚刺激を用いた痴呆高齢者の誤嚥性肺炎予防に関する研究
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
2005 - 2007
渡邊 裕
[fMRIによる研究]
嚥下運動に関連した視覚聴覚刺激を提示した時の脳野の賦活をfMRIを用いて検討した。これにより嚥下運動に関連した聴覚刺激、視覚刺激、及び視聴覚刺激によっても嚥下運動のプログラムから実行に関与するといわれる脳領域が賦活することが証明された。この研究成果は15th International Dysphagia Research Society(カナダ)にて発表し、現在論文投稿中である
[脳磁図による研究]
東京歯科大学・口腔科学センターの脳磁図を用いて健常者に嚥下運動に関連した視覚・聴覚刺激を行なったときの脳皮質活動を検討した。これにより嚥下運動に関連した聴覚刺激、視覚刺激を行なった時の脳賦活領域(前年度fMRIで賦活が証明された部位)の時間経過が証明された。この研究成果は16th International Dysphagia Research Society(アメリカ)にて発表し、現在論文投稿中である
[介護老人保健施設における介入研究]
脳卒中後遺症の摂食・嚥下障害患者に対し、fMRIと脳磁図においてその有用性が証明された嚥下運動に関連した視覚・聴覚刺激を用いてバイオフィードバック療法を行なった。結果、嚥下誘発時間の有意な短縮が認められ、このバイオフィードバック療法の有用性が示唆された。
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Tokyo Dental College, 17791585

バイオマーカーによって特定された口腔癌周囲組織の機能異常を探るプロジェクト
Grants-in-Aid for Scientific Research Grant-in-Aid for Exploratory Research
2004 - 2006
阿部 伸一; 上松 博子; 渡邊 裕
我々が口腔癌のバイオマーカーとしてこれまで注目し研究を行ってきたHigh Mobility Group I(Y)[HMGI(Y)]は染色質の構造維持や様々な遺伝子の転写を制御している非ヒストンDNA結合タンパクである。これまでヒト大腸組織において、HMGI(Y)過剰発現が癌特異的に認められることは報告済みであるが、本年度我々は、マウスにおいて実験的に作製した舌癌モデルマウスの病巣周囲においてもHMGI(Y)が過剰発現していることを確認し、さらに周囲の筋線維の特性を検索した。この結果、口腔癌予後予測因子としてHMGI(Y)発現レベルの有用性が実証されてきたと考えている。今後このバイオマーカーによる癌病巣の予防的切除、術後の再発などが予測できるようになると思われた。次に筋組織は周囲の環境によってその特性を大きく変えることから、癌ではなくても正常な機能は発揮できていないことも考えられるが、これまでの癌研究においてバイオマーカーより外側の正常組織にまで視点を広げ、詳細に本来の組織との分子機構の違いを検討したものはみられない。そこで、正常筋組織の分子機構を知らなくてはならないが、今年度も昨年度同様、特に頭部における正常筋組織の成長過程における筋線維特性分子機構の変化について研究、論文作成を行った。この3年間の研究で、筋は周囲の機能変化をシグナルとして受け取り、筋収縮蛋白の組成を変化させていることが様々な面から明らかとなった。今後は口腔癌周囲組織が正常な筋線維特性を獲得していく詳細な分子機構について解明していきたいと考えている。
Japan Society for the Promotion of Science, Grant-in-Aid for Exploratory Research, Tokyo Dental College, 16659502

Fundamental study for clarifying dysphagia : The role of upper brain in inducing swallowing
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
2002 - 2005
YAMADA Yoshiaki; YAMAMURA Kensuke; INOUE Makoto; ABE Shinichi; WATANABE Yutaka; MAEDA Takeyasu
Mechanical stimulation to pharyngeal and/or laryngeal region has long been believed to elicit swallow reflexively irrespective of the cortical situation. However, videofluorographic (VF) study has revealed that some food may be transported to the pharynx during mastication. Interestingly, the bolus dropped in the pharynx does not elicit swallow till the chewing process is completed. The project was thus designed to seek possible cortical regions which could affect swallowing center, in which magneto-encephalogram and VF were applied for human subjects and kinesiological and electrophysiological methods for animals.
In rabbits, the ingestive behavior, from food intake to swallowing, could be recorded and identified. The coordination between tongue and masticatory muscles and the role of facial (cheek and lip) muscles during mastication were clarified. To seek a possible cortical region for swallowing, rabbit's cortex was systematically stimulated. Then the region, where swallows were facilitated or inhibited during chewing, was identified. However, no concrete region where the swallow could be elicited solely was identified. We believe that in animals with crudely developed cortex, the region may be limited in a small area or even voluntary swallow itself may not be developed.
Magneto-encephalogram showed that the cingulate cortex was active for short time about 2 sec preceding voluntary swallows and the insula and operculum were active for long period till swallows occurred. Since cingulate cortex is known as a region relating to emotion, it is concluded that the activation in this region may be related to a recognition process of food. Insula and operculum is known to have a direct connection with the swallowing center, thereafter, the region may be the main one for cortical elicitation of swallows. VF studies revealed that humans swallow two or three times when they clear the mouth of mouthful food as has been reported in animal studies.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Niigata University, 14207077

摂食・嚥下機能障害回復過程での中枢における代償性変化に関する研究
Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A)
2000 - 2001
渡邊 裕
嚥下機能は通常延髄における反射が主体をなすものの、各種の障害によりその機能が低下すると、その回復過程において随意的な嚥下訓練を行うことが肝要となる。よって随意的な嚥下運動の中枢制御機構を解明することは重要である。そこで、随意運動の中枢制御機構を検索するため、片側の単純な中指の伸展運動と両側性で多数の筋が協調する嚥下運動時の脳磁場計測を行った。
研究方法:右利きの健康成人7名を被験者とした。計測は306チャンネル全頭型脳磁図計を用いた。脳磁場の加算はそれぞれ30回以上とし、加算の基準は運動関連筋の筋電積分波形の立ち上がりとした。データは運動開始前の2500msから開始後の500msまでを検証し、電流双極子モデルの適合度(GOF)が75%以上のものについて等価電流双極子の位置をMRI画像上に適合させた。
研究の評価および考察:嚥下運動開始前の2000ms前後で帯状回、補足運動野のいずれかの活動が推定された。この後、2000msから1300msの間に左側の前頭回の活動が推定された。島の活動については時間的局在は認められず全時間帯で活動が推定された。しかし、中指の伸展運動では等価電流双極子の推定は行えなかった。
研究の評価および考察:fMRIによる嚥下関連の大脳皮質活動部位の研究では、島、帯状回、前頭前野などに活動がみられたとの報告がある。fMRIはその性質上活動部位の時間経過を検索することはできないが、今回我々が得た結果はこれとほぼ同様の結果を示し、なお時間経過も検索されていることから有効なものと思われた。指の伸展運動に関して運動準備期の活動源推定が行えないことは、単純な運動のため、複雑な中枢制御が不要であるためとも考えられるが、計測方法の問題も否定できない。今後より随意性を要求される、指の巧緻運動などの計測を行う必要があると思われた。
Japan Society for the Promotion of Science, Grant-in-Aid for Encouragement of Young Scientists (A), Tokyo Dental College, 12771242

高次脳機能を用いた口腔ケアプラン作成に関する研究
Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A)
1998 - 1999
渡邊 裕
既存の高次脳機能評価スケールから口腔ケアと関連の深いものを抜粋複合した口腔ケア高次脳機能評価スケールを作成した。これを日常診療において度重なる口腔清掃指導にも関わらず口腔清掃状態の改善の認められない患者30名に対し施行し、高次脳機能のスクリーニング検査をおこなった。同時に口腔に関する評価(残存歯数、その状態、補綴物、口腔清掃状態、口腔ケア自立度)を行なった。スクリーニング検査後精査を行い、構成失行、身体失認、視空間認知障害と診断された4名の口腔の状態を検討したところ、明らかに本障害に起因する特定の部分的な歯牙の早期喪失や、口腔清掃状態の不良が認められ、さらに、同部位の口腔清掃指導の効果が他の部位と比較し認められなかった。これらの患者に対して高次脳機能障害の治療に用いられている学習転移アプローチ、感覚統合的アプローチにて口腔清掃指導を行ったところ効果が認められた。これより高次脳機能障害別の口腔ケアマニュアルの作成を行った。
以上の結果より高次脳機能、特に空間認知に関する機能が、口腔ケアに関連が深いことが示唆された。そこでより精密に空間認知に関する機能をはかるため、健常ボランティア30名に対し、口腔ケア高次脳機能評価スケールと口腔内各部位の認知検査、口腔に関する評価を行なった。口腔内各部位の認知検査において30名の平均より有意に差の認められた、被験者の同部位に関する口腔清掃状態、歯牙の補綴状況は、その他の被験者ならびに同一被験者の他の部位のものより劣っていた。すなわち潜在的な空間認知に関する高次脳機能障害が口腔ケアに影響することが示唆された。
健常者では口腔ケア高次脳機能評価スケールと口腔内各部位の認知検査に有意な相関は見られなかったが、口腔ケアの介助を必要とする要介護者にとっては、有用で簡便なスクリーニング検査となると思われた。
Japan Society for the Promotion of Science, Grant-in-Aid for Encouragement of Young Scientists (A), Tokyo Dental College, 10771200