Researcher basic information

• 博士（歯学）, 北海道大学

• https://researchmap.jp/read0116780?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901053130604972

• 40507571

• 200901053130604972

• nano technology
• β-TCP
• Emulsion
• FGF-2
• Collagen Hydrogel-sponge Composite
• BMP-2
• periodontal regeneration

• Life Science, Conservative dentistry, Periodontal regeneration

• Bachelor's degree program, School of Dental Medicine
• Doctoral (PhD) degree program, Graduate school of Dental Medicine

Research activity information

• Jun. 2023, The Japanese Society of Conservative Dentistry, 2022年度年間優秀論文賞 歯内療法学分野（カボデンタル優秀論文賞）
  In Vivo Inflammatory Effects and Surface Composition Changes in Implanted Root Canal Sealer Containing Bioactive Glass
  Akihito Kato, Official journal

• Characterization and Biocompatibility Evaluation of Zinc Oxide Eugenol-Based Paste Root Canal Sealer
  KATO Akihito; MIYAJI Hirofumi; KANEMOTO Yukimi; SHITOMI Kanako; OKAMOTO Ichie; YOSHINO Yuto; HAMAMOTO Asako; NISHIDA Erika; SUGAYA Tsutomu; TANAKA Saori
  The Japanese Journal of Conservative Dentistry, 66, 2, 114, 123, (NPO)日本歯科保存学会, Apr. 2023, [Peer-reviewed], [Lead author]
  Japanese, Scientific journal
• Periodontal tissue regeneration by recombinant human collagen peptide granules applied with β-tricalcium phosphate fine particles.
  Yuto Yoshino; Hirofumi Miyaji; Erika Nishida; Yukimi Kanemoto; Asako Hamamoto; Akihito Kato; Tsutomu Sugaya; Tsukasa Akasaka
  Journal of oral biosciences, 65, 1, 62, 71, 17 Jan. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal, OBJECTIVES: Recombinant human collagen peptide (RCP) is a recombinantly created xeno-free biomaterial enriched in arginine-glycine-aspartic acid sequences with good processability whose use for regenerative medicine applications is under investigation. The biocompatibility and osteogenic ability of RCP granules combined with β-tricalcium phosphate (TCP) submicron particles (β-TCP/RCP) were recently demonstrated. In the present study, β-TCP/RCP was implanted into experimental periodontal tissue defects created in beagles to investigate its regenerative effects. METHODS: An RCP solution was lyophilized, granulated, and thermally cross-linked into particles approximately 1 mm in diameter. β-TCP dispersion (1 wt%; 500 μL) was added to 100 mg of RCP granules to form β-TCP/RCP. A three-walled intrabony defect (5 mm × 3 mm × 4 mm) was created on the mesial side of the mandibular first molar and filled with β-TCP/RCP. RESULTS: A micro-computed tomography image analysis performed at 8 weeks postoperative showed a significantly greater amount of new bone after β-TCP/RCP grafting (2.2-fold, P<0.05) than after no grafting. Histological findings showed that the transplanted β-TCP/RCP induced active bone-like tissue formation including tartaric acid-resistant acid phosphatase- and OCN-positive cells as well as bioabsorbability. Ankylosis did not occur, and periostin-positive periodontal ligament-like tissue formation was observed. Histological measurements performed at 8 weeks postoperative revealed that β-TCP/RCP implantation formed 1.7-fold more bone-like tissue and 2.1-fold more periodontal ligament-like tissue than the control condition and significantly suppressed gingival recession and epithelial downgrowth (P<0.05). CONCLUSIONS: β-TCP/RCP implantation promoted bone-like and periodontal ligament-like tissue formation, suggesting its efficacy as a periodontal tissue regenerative material.
• Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment
  Hirofumi Miyaji; Yukimi Kanemoto; Asako Hamamoto; Kanako Shitomi; Erika Nishida; Akihito Kato; Tsutomu Sugaya; Saori Tanaka; Natsuha Aikawa; Hideya Kawasaki; Syun Gohda; Hironobu Ono
  Scientific Reports, 12, 1, 16721, 16721, Springer Science and Business Media LLC, 18 Oct. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Abstract
  
  Antimicrobial surfactants contained in mouthrinse have excellent efficacy, but are not retained on the tooth surface (are rinsed away) due to their low water resistance and thus do not exhibit sustained antibacterial activity. We have developed a new coating method using graphene oxide (GO) that retains the surfactant on the tooth surface even after rinsing with water, thus providing a sustained antibacterial effect. Ultra-thin films of GO and an antimicrobial agent were prepared by (1) applying GO to the substrate surface, drying, and thoroughly rinsing with water to remove excess GO to form an ultrathin film (almost a monolayer, transparent) on the substrate surface, then (2) applying antimicrobial cationic surface active agents (CSAAs) on the GO film to form a composite coating film (GO/CSAA). GO/CSAA formation was verified by scanning electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, and ζ-potential and contact angle measurements. GO/CSAA was effective at inhibiting the growth of oral pathogens for up to 7 days of storage in water, and antibacterial activity was recovered by reapplication of the CSAA. Antibacterial GO/CSAA films were also formed on a tooth substrate. The results suggest that GO/CSAA coatings are effective in preventing oral infections.
• Ultrasonic irrigation of periodontal pocket with surface pre-reacted glass-ionomer (S-PRG) nanofiller dispersion improves periodontal parameters in beagle dogs.
  Hirofumi Miyaji; Kayoko Mayumi; Yukimi Kanemoto; Ichie Okamoto; Asako Hamamoto; Akihito Kato; Tsutomu Sugaya; Tsukasa Akasaka; Saori Tanaka
  Journal of oral biosciences, 64, 2, 222, 228, Jun. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, OBJECTIVES: Surface pre-reacted glass-ionomer (S-PRG) nanofiller, an antibacterial ion-releasing bioactive glass, has been shown to adhere to tooth surfaces and reported to improve inflammatory parameters in experimental periodontitis. In this study, cementum substrate was irrigated ultrasonically with dispersion to examine in-vitro nanofiller adhesion and antibacterial activity. Moreover, periodontal pockets in a beagle dog were ultrasonically irrigated with dispersion to assess periodontal healing. METHODS: The morphology of human cementum irrigated with S-PRG nanofiller dispersion was examined by scanning electron microscopy and energy dispersive X-ray spectrometry. The antibacterial activity of the treated cementum was tested using Actinomyces naeslundii. In addition, experimentally formed periodontal pockets in beagle dog were ultrasonically irrigated with S-PRG nanofiller dispersion. Periodontal parameters (gingival index, bleeding on probing, probing pocket depth, and clinical attachment level) were measured from baseline (0 weeks) through 12 weeks. Moreover, the effects of irrigation with S-PRG nanofiller on changes in periodontal microflora and bone healing were analyzed. RESULTS: After ultrasonic irrigation, S-PRG nanofiller adhered to the cementum and exhibited antibacterial activity. The periodontal parameters were shown to improve following ultrasonic irrigation with S-PRG nanofiller dispersion. Analysis by next-generation sequencing revealed that the ratio of red-complex species decreased in the pockets irrigated with S-PRG nanofiller dispersion. In addition, the S-PRG nanofiller showed the potential to promote bone healing. CONCLUSIONS: Ultrasonic irrigation with S-PRG nanofiller dispersion using an ultrasonic scaler system permitted delivery of the S-PRG nanofiller to the root surface, providing improved parameters in experimental periodontitis and modifying the composition of subgingival periodontal microflora.
• In Vivo Inflammatory Effects and Surface Composition Changes in Implanted Root Canal Sealer Containing Bioactive Glass
  Akihito KATO; Hirofumi MIYAJI; Yuto YOSHINO; Yukimi KANEMOTO; Asako HAMAMOTO; Erika NISHIDA; Tsutomu SUGAYA; Saori TANAKA
  The Japanese Journal of Conservative Dentistry, 65, 2, 145, 153, The Japanese Society of Conservative Dentistry, 30 Apr. 2022, [Peer-reviewed], [Lead author]
  Japanese, Scientific journal
• Periodontal tissue engineering using an apatite/collagen scaffold obtained by a plasma- and precursor-assisted biomimetic process
  Yukimi Kanemoto; Hirofumi Miyaji; Erika Nishida; Saori Miyata; Kayoko Mayumi; Yuto Yoshino; Akihito Kato; Tsutomu Sugaya; Tsukasa Akasaka; Arputharaj Joseph Nathanael; Syama Santhakumar; Ayako Oyane
  Journal of Periodontal Research, 57, 205, 218, Jan. 2022, [Peer-reviewed]
  English, Scientific journal
• Suppression of root caries progression by application of Nanoseal®: A single-blind randomized clinical trial.
  Hirofumi Miyaji; Akihito Kato; Saori Tanaka
  Dental materials journal, 39, 3, 444, 448, 05 Jun. 2020, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, The aim of this single-blind, parallel and randomized controlled trial was to evaluate the effect of Nanoseal® application on root caries progression. Adult patients (n=129, mean age: 66.4±10.1 years) with root caries were randomly allocated into three groups: high-frequency (HF, n=43; intervention: Nanoseal application at baseline and 1-5 months), low-frequency (LF, n=43; intervention: Nanoseal application at baseline and 3 months), and control (n=43; intervention: no application of Nanoseal) groups. Measurements of fluorescence laser values of carious lesions using a DIAGNOdent™ Pen (D-value) were performed for each subject before intervention (baseline) and at 3 and 6 months. Significantly lower D-values for the HF (p=0.017) and LF (p=0.034) groups were observed compared with the control group at 6 months. Nanoseal application would be an effective procedure to suppress root caries progression.
• Bone forming ability of recombinant human collagen peptide granules applied with beta-tricalcium phosphate fine particles
  Tomokazu Furihata; Hirofumi Miyaji; Erika Nishida; Akihito Kato; Saori Miyata; Kanako Shitomi; Kayoko Mayumi; Yukimi Kanemoto; Tsutomu Sugaya; Tsukasa Akasaka
  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108, 7, 3033, 3044, May 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Assessments of Biocompatibility of Root Canal Sealer Containing S-PRG Filler
  TANAKA Saori; MIYAJI Hirofumi; NISHIDA Erika; MIYATA Saori; KATO Akihito; MAYUMI Kayoko; TANAKA Toru; INOUE Satoshi
  The Japanese Journal of Conservative Dentistry, 62, 2, 107, 114, (NPO)日本歯科保存学会, Apr. 2019, [Peer-reviewed]
  Japanese
• Near-infrared Irradiation and Graphene Oxide Film Fabricated on Dentin Surface Exhibit Photothermal and Antibacterial Effects
  Nagao Keishi; Miyaji Hirofumi; Nishida Erika; Akasaka Tsukasa; Miyata Saori; Shitomi Kanako; Mayumi Kayoko; Kato Akihito; Sugaya Tsutomu
  Journal of Oral Hygiene & Health, 6, 1, 231, 231, OMICS International, 10 Jan. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog.
  Kohei Kawamoto; Hirofumi Miyaji; Erika Nishida; Saori Miyata; Akihito Kato; Akito Tateyama; Tomokazu Furihata; Kanako Shitomi; Toshihiko Iwanaga; Tsutomu Sugaya
  International journal of nanomedicine, 13, 2365, 2376, 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Introduction: The 3-dimensional scaffold plays a key role in volume and quality of repair tissue in periodontal tissue engineering therapy. We fabricated a novel 3D collagen scaffold containing carbon-based 2-dimensional layered material, named graphene oxide (GO). The aim of this study was to characterize and assess GO scaffold for periodontal tissue healing of class II furcation defects in dog. Materials and methods: GO scaffolds were prepared by coating the surface of a 3D collagen sponge scaffold with GO dispersion. Scaffolds were characterized using cytotoxicity and tissue reactivity tests. In addition, GO scaffold was implanted into dog class II furcation defects and periodontal healing was investigated at 4 weeks postsurgery. Results: GO scaffold exhibited low cytotoxicity and enhanced cellular ingrowth behavior and rat bone forming ability. In addition, GO scaffold stimulated healing of dog class II furcation defects. Periodontal attachment formation, including alveolar bone, periodontal ligament-like tissue, and cementum-like tissue, was significantly increased by GO scaffold implantation, compared with untreated scaffold. Conclusion: The results suggest that GO scaffold is biocompatible and possesses excellent bone and periodontal tissue formation ability. Therefore, GO scaffold would be beneficial for periodontal tissue engineering therapy.
• シンバスタチン含有α型リン酸トリカルシウムミクロ粒子懸濁液による骨誘導(Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin)
  Tateyama Akito; Kato Akihito; Miyaji Hirofumi; Nishida Erika; Iwasaki Yasuhiko; Fujii Syuji; Kawamoto Kohei; Shitomi Kanako; Furihata Tomokazu; Mayumi Kayoko; Sugaya Tsutomu
  Nano Biomedicine, 9, 2, 69, 76, ナノ・バイオメディカル学会, Dec. 2017, [Peer-reviewed]
  English, 骨移植材の分解性と操作性を改善するため、α型リン酸トリカルシウム(α-TCP)骨ペーストを基にした水-オイル懸濁液を調製した。親油性の抗高脂血症薬であるシンバスタチン(SIM)には骨形成促進作用が認められているため、SIM含有α-TCP骨ペーストを用いてラットの頭蓋骨欠損に対する骨形成効果を評価した。骨ペーストは固化後に多孔性構造とヒドロキシアパタイトの生成を示すので、頭蓋骨欠損部への移植後にX線画像解析と組織学的検査を行った。骨ペーストのSIM含有量は0、0.01、0.1および1mgとし、無SIMの対照骨ペーストと比較した。その結果、骨ペースト移植後に新たな骨形成が認められ、特に0.1mg SIM群では対照群に比べて骨体積が有意に促進され、術後4週では骨欠損部に骨ペースト残渣は見られなかった。以上より、SIM含有α-TCP骨ペーストは分解性であり、骨組織工学にとって有用であることが示唆された。
• Periodontal tissue engineering by nano beta-tricalcium phosphate scaffold and fibroblast growth factor-2 in one-wall infrabony defects of dogs
  K. Ogawa; H. Miyaji; A. Kato; Y. Kosen; T. Momose; T. Yoshida; E. Nishida; S. Miyata; S. Murakami; H. Takita; B. Fugetsu; T. Sugaya; M. Kawanami
  Journal of Periodontal Research, 51, 6, 758, 767, Dec. 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Bone-forming effects of collagen scaffold containing β-tricalcium phosphate nanoparticles on extraction sockets in dogs
  KATO Akihito; MIYAJI Hirofumi; OGAWA Kosuke; MOMOSE Takehito; NISHIDA Erika; MURAKAMI Syusuke; YOSHIDA Takashi; TANAKA Saori; SUGAYA Tsutomu; KAWANAMI Masamitsu
  日本歯科保存学雑誌, 59, 4, 351, 358, (NPO)日本歯科保存学会, Aug. 2016, [Peer-reviewed], [Lead author]
  Japanese, Scientific journal
• Modification of Composite Resin Surface with Carbon Nanotubes Enhances Cell Proliferation
  Saori TANAKA; Hirofumi MIYAJI; Erika NISHIDA; Kana INOUE; Saori MIYATA; Akihito KATO; Izumi KANAYAMA; Shusuke MURAKAMI; Kohei KAWAMOTO; Bunshi FUGETSU; Toru TANAKA; Hiroko TAKITA; Tadashi IIZUKA; Masamitsu KAWANAMI
  Nano Biomedicine, 8, 1, 27, 34, Jun. 2016, [Peer-reviewed]
  English, Scientific journal
• Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket
  Erika Nishida; Hirofumi Miyaji; Akihito Kato; Hiroko Takita; Toshihiko Iwanaga; Takehito Momose; Kosuke Ogawa; Shusuke Murakami; Tsutomu Sugaya; Masamitsu Kawanami
  INTERNATIONAL JOURNAL OF NANOMEDICINE, 11, 2265, 2277, 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Collagen Hydrogel Scaffold and Fibroblast Growth Factor-2 Accelerate Periodontal Healing of Class II Furcation Defects in Dog.
  Takehito Momose; Hirofumi Miyaji; Akihito Kato; Kosuke Ogawa; Takashi Yoshida; Erika Nishida; Syusuke Murakami; Yuta Kosen; Tsutomu Sugaya; Masamitsu Kawanami
  The open dentistry journal, 10, 347, 59, 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal, OBJECTIVE: Collagen hydrogel scaffold exhibits bio-safe properties and facilitates periodontal wound healing. However, regenerated tissue volume is insufficient. Fibroblast growth factor-2 (FGF2) up-regulates cell behaviors and subsequent wound healing. We evaluated whether periodontal wound healing is promoted by application of collagen hydrogel scaffold in combination with FGF2 in furcation defects in beagle dogs. METHODS: Collagen hydrogel was fabricated from bovine type I collagen with an ascorbate-copper ion cross-linking system. Collagen hydrogel was mingled with FGF2 and injected into sponge-form collagen. Subsequently, FGF2 (50 µg)/collagen hydrogel scaffold and collagen hydrogel scaffold alone were implanted into class II furcation defects in dogs. In addition, no implantation was performed as a control. Histometric parameters were assessed at 10 days and 4 weeks after surgery. RESULT: FGF2 application to scaffold promoted considerable cell and tissue ingrowth containing numerous cells and blood vessel-like structure at day 10. At 4 weeks, reconstruction of alveolar bone was stimulated by implantation of scaffold loaded with FGF2. Furthermore, periodontal attachment, consisting of cementum-like tissue, periodontal ligament-like tissue and Sharpey's fibers, was also repaired, indicating that FGF2-loaded scaffold guided self-assembly and then re-established the function of periodontal organs. Aberrant healing, such as ankylosis and root resorption, was not observed. CONCLUSION: FGF2-loaded collagen hydrogel scaffold possessed excellent biocompatibility and strongly promoted periodontal tissue engineering, including periodontal attachment re-organization.
• Biological Response to Nanostructure of Carbon Nanotube/titanium Composite Surfaces
  NISHIDA Erika; MIYAJI Hirofumi; UMEDA Junko; KONDOH Katsuyoshi; TAKITA Hiroko; KANAYAMA Izumi; TANAKA Saori; KATO Akihito; FUGETSU Bunshi; AKASAKA Tsukasa; KAWANAMI Masamitsu
  Nano Biomedicine, 7, 1, 11, 20, Jun. 2015, [Peer-reviewed]
  English, Scientific journal
• Combination of Root Surface Modification with BMP-2 and Collagen Hydrogel Scaffold Implantation for Periodontal Healing in Beagle Dogs.
  Akihito Kato; Hirofumi Miyaji; Ryosuke Ishizuka; Keisuke Tokunaga; Kana Inoue; Yuta Kosen; Hiroyuki Yokoyama; Tsutomu Sugaya; Saori Tanaka; Ryuji Sakagami; Masamitsu Kawanami
  The open dentistry journal, 9, 52, 9, 2015, [Peer-reviewed], [International Magazine]
  English, Scientific journal, UNLABELLED: Objective : Biomodification of the root surface plays a major role in periodontal wound healing. Root surface modification with bone morphogenetic protein (BMP) stimulates bone and cementum-like tissue formation; however, severe ankylosis is simultaneously observed. Bio-safe collagen hydrogel scaffolds may therefore be useful for supplying periodontal ligament cells and preventing ankylosis. We examined the effects of BMP modification in conjunction with collagen hydrogel scaffold implantation on periodontal wound healing in dogs. MATERIAL AND METHODS: The collagen hydrogel scaffold was composed of type I collagen sponge and collagen hydrogel. One-wall infrabony defects (5 mm in depth, 3 mm in width) were surgically created in six beagle dogs. In the BMP/Col group, BMP-2 was applied to the root surface (loading dose; 1 µg/µl), and the defects were filled with collagen hydrogel scaffold. In the BMP or Col group, BMP-2 coating or scaffold implantation was performed. Histometric parameters were evaluated at 4 weeks after surgery. RESULTS: Single use of BMP stimulated formation of alveolar bone and ankylosis. In contrast, the BMP/Col group frequently enhanced reconstruction of periodontal attachment including cementum-like tissue, periodontal ligament and alveolar bone. The amount of new periodontal ligament in the BMP/Col group was significantly greater when compared to all other groups. In addition, ankylosis was rarely observed in the BMP/Col group. CONCLUSION: The combination method using root surface modification with BMP and collagen hydrogel scaffold implantation facilitated the reestablishment of periodontal attachment. BMP-related ankylosis was suppressed by implantation of collagen hydrogel.
• Application of collagen hydrogel/sponge scaffold facilitates periodontal wound healing in class II furcation defects in beagle dogs
  Y. Kosen; H. Miyaji; A. Kato; T. Sugaya; M. Kawanami
  Journal of Periodontal Research, 47, 5, 626, 634, Oct. 2012, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Periodontal Healing by Implantation of Collagen Hydrogel-sponge Composite in One-wall Infrabony Defects in Beagle Dogs
  KATO Akihito; MIYAJI Hirofumi; KOSEN Yuta; YOKOYAMA Hiroyuki; ISHIZUKA Ryosuke; TOKUNAGA Keisuke; INOUE Kana; HENMI Masaru; TANAKA Saori; SUGAYA Tsutomu; KAWANAMI Masamitsu
  J Oral Tissue Eng, 8, 1, 39, 46, Japanese Association of Regenerative Dentistry, Dec. 2010, [Peer-reviewed]
  English, Scientific journal, The purpose of this study was to evaluate the effect of implanted collagen hydrogel-sponge composite on periodontal wound healing. One-wall infrabony defects (depth: 5 mm; width: 3 mm) were surgically created in three beagle dogs. The exposed root surface was planed and demineralized with EDTA. In the experimental group, the defects were filled with collagen hydrogel-sponge composite. Conversely, no collagen hydrogel-sponge composite was applied to defects in the control group. Histomorphometric parameters were evaluated four weeks after surgery. In the experimental group, regeneration of alveolar bone and cementum was frequently observed. Periodontal ligament tissue was reestablished between the alveolar bone and cementum. New bone height, new bone area, new cementum and new periodontal ligament in the experimental group were significantly greater than those in the control group (p < 0.05). These findings suggest that implanted collagen hydrogel-sponge composite facilitates periodontal wound healing in one-wall infrabony defects in beagle dogs.
• Effect of BMP-2 application to root dentin surface on periodontal regeneration in 1-wall infrabony defects
  KATO AKIHITO; MIYAJI HIROFUMI; SUGAYA TSUTOMU; KAWANAMI MASAMITSU
  日本歯周病学会会誌, 49, 4, 296, 304, (NPO)日本歯周病学会, Dec. 2007, [Peer-reviewed]
  Japanese, Scientific journal

• BMPを用いた歯周組織再生療法の開発
  宮治裕史; 菅谷勉; 加藤昭人; 齋藤彰; 小田島朝臣; 齋藤恵美子; 川浪雅光, 日本歯科評論, 68, 786, 39-40,HYOSHI, 40, 11 Apr. 2008
  (株)ヒョーロン・パブリッシャーズ, Japanese

• Clinical Effects of CPC Mouthwash Combined with Scaling on Periodontitis with Poor Plaque Control
  竹生 寛恵; 工藤 愛; 下地 伸司; 小田島 朝臣; 加藤 昭人; 鷲巣 太郎; 町田 紗樹; 高橋 直紀; 田中 佐織; 菅谷 勉
  第68回秋季日本歯周病学会学術大会, 17 Oct. 2025, (NPO)日本歯周病学会, Japanese, Poster presentation
  17 Oct. 2025 - 18 Oct. 2025
• Tissue response to calcium hydroxide root filling formulation in rat bone defect
  田中 佐織; 宮治 裕史; 加藤 昭人; 金本 佑生実; 菅谷 勉
  日本歯科保存学会2023年度春季学術大会（第158回）, 23 Jun. 2023, (NPO)日本歯科保存学会, Japanese, Poster presentation
  22 Jun. 2023 - 23 Jun. 2023, [Domestic Conference]
• Periodontal regenerative effect of collagen type I-based recombinant peptide/β-tricalcium phosphate bone graft material
  吉野 友都; 宮治 裕史; 西田 絵利香; 金本 佑生実; 浜本 朝子; 加藤 昭人; 菅谷 勉; 赤坂 司
  第66回春季日本歯周病学会学術大会, 26 May 2023, (NPO)日本歯周病学会, Japanese, Poster presentation
  26 May 2023 - 27 May 2023, [Domestic Conference]
• 酸化グラフェンとカオチン界面活性剤による透明超薄膜コーティングの持続的抗菌効果
  宮治 裕史; 金本 佑生実; 浜本 朝子; 蔀 佳奈子; 西田 絵利香; 加藤 昭人; 菅谷 勉; 田中 佐織; 相川 夏葉; 川崎 英也; 郷田 隼; 小野 博信
  第44回日本バイオマテリアル学会大会, 22 Nov. 2022, 日本バイオマテリアル学会, Japanese, Poster presentation
  21 Nov. 2022 - 22 Nov. 2022, Japan, [Domestic Conference]
• Low-crystalline apatite-coated scaffold obtained by a precursor-assisted biomimetic process; Assessments of bone and periodontal tissue forming ability
  金本 佑生実; 宮治 裕史; 西田 絵利香; 宮田 さほり; 眞弓 佳代子; 吉野 友都; 加藤 昭人; 菅谷 勉; 赤坂 司; 大矢根 綾子
  第65回秋季日本歯周病学会学術大会, 02 Sep. 2022, (NPO)日本歯周病学会, Japanese, Poster presentation
  02 Sep. 2022 - 03 Sep. 2022, [Domestic Conference]
• Improvement of periodontitis by ultrasonic scaler in combination with S-PRG nanofiller dispersion irrigation
  宮治 裕史; 眞弓 佳代子; 金本 佑生実; 岡本 一絵; 浜本 朝子; 加藤 昭人; 菅谷 勉; 赤坂 司; 田中 佐織
  第65回秋季日本歯周病学会学術大会, 02 Sep. 2022, (NPO)日本歯周病学会, Japanese, Poster presentation
  02 Sep. 2022 - 03 Sep. 2022, [Domestic Conference]
• 酸化グラフェン超薄膜コーティングへの口腔洗浄含嗽剤の複合化による持続性抗菌効果
  宮治裕史; 金本佑生実; 浜本朝子; 西田絵利香; 加藤昭人; 菅谷 勉; 田中佐織; 郷田 隼; 小野博信
  日本歯科保存学会2022年度春季学術大会（第156回）, 16 Jun. 2022, 日本歯科保存学会, Japanese, Poster presentation
  16 Jun. 2022 - 29 Jun. 2022, web開催, Japan
• Elemental composition analysis of root canal sealer containing bioactive glass implanted into rat subcutaneous tissue
  宮治裕史; 吉野友都; 加藤昭人; 菅谷勉; 田中佐織; 田中佐織
  日本歯科保存学会2021年度春季学術大会（第154回）, 10 Jun. 2021, 日本歯科保存学会, Japanese, Poster presentation
  10 Jun. 2021 - 23 Jun. 2021, web開催, Japan, [Domestic Conference]
• ヒトⅠ型コラーゲン様リコンビナントペプチド骨補填材の開発と骨再生効果
  宮治裕史; 西田絵利香; 加藤昭人; 金本佑生実; 吉野友都; 菅谷勉; 赤坂司
  第33回北海道骨粗鬆症研究会学術集会, 27 Feb. 2021, Japanese, Oral presentation
  27 Feb. 2021 - 27 Feb. 2021
• Biocompatible assessments of root canal sealer containing bioactive glass
  吉野 友都; 宮治 裕史; 金本 佑生実; 浜本 朝子; 西田 絵利香; 加藤 昭人; 菅谷 勉; 田中 佐織
  日本歯科保存学会2020年度春季学術大会（第152回）, 11 Jun. 2020, 日本歯科保存学会, Japanese, Poster presentation
  11 Jun. 2020 - 12 Jun. 2020, 誌上開催, Japan, [Domestic Conference]
• 金銀クラスター/ローズベンガル含有キトサンナノゲル複合体の光線力学的特性
  浜本 朝子; 加藤 昭人; 宮田 さほり; 蔀 佳奈子; 宮治 裕史; 菅谷 勉; 齋田 慧; 川崎 英也
  北海道外科雑誌, Jun. 2020, 北海道外科学会, Japanese
  Jun. 2020 - Jun. 2020
• ヒトI型コラーゲン様リコンビナントペプチド/サブミクロンβ-TCP骨補填材による骨形成効果
  西田絵利香; 宮治裕史; 降籏友和; 加藤昭人; 宮田さほり; 蔀佳奈子; 眞弓佳代子; 金本佑生実; 菅谷勉; 赤坂司
  第41回日本バイオマテリアル学会大会, 25 Nov. 2019, 日本バイオマテリアル学会, Poster presentation
  24 Nov. 2019 - 26 Nov. 2019, [Domestic Conference]
• 合金クラスター／ローズベンガル含有キトサンナノゲルの抗菌性評価
  加藤昭人; 宮治裕史; 齋田慧; 川﨑英也
  第41回日本バイオマテリアル学会大会, 25 Nov. 2019, 日本バイオマテリアル学会, Poster presentation
  24 Nov. 2019 - 26 Nov. 2019, [Domestic Conference]
• Application of nano-S-PRG filler-dispersed liquid and ultrasonic scaler/irrigation system to obtain antibacterial tooth surface
  Kayoko Mayumi; Hirofumi Miyaji; Ichie Okamoto; Akihito Katou; Tutomu Sugaya
  第62回秋季日本歯周病学会学術大会, 25 Oct. 2019, Japanese, Poster presentation
  [Domestic Conference]
• Bone inductive effect of human recombinant collagen type I peptide-based bone graft containing β-TCP nanoparticles
  Tomokazu Furihata; Hirohumi Miyaji; Erika Nishida; Akihito Kato; Saori Miyata; Kanako Shitomi; Kayoko Mayumi; Yukimi Kanemoto; Tsutomu Sugaya; Tsukasa Akasaka
  第62回秋季日本歯周病学会学術大会, 25 Oct. 2019, Japanese, Oral presentation
• ナノβ‐TCP/ヒトI型コラーゲン様リコンビナントペプチド顆粒の骨形成特性評価
  西田絵利香; 宮治裕史; 降籏友和; 宮田さほり; 加藤昭人; 金本佑生実; 菅谷勉; 赤坂司
  第18回日本再生医療学会総会, 22 Mar. 2019, Japanese, Poster presentation
  神戸市, [Domestic Conference]
• Characterization and bone-inductive effect of bone paste using particle emulsion of α-TCP containing simvastatin.
  Akito Tateyama; Akihito Kato; Hirofumi Miyaji; Erika Nishida; Yasuhiko Iwasaki; Syuji Fujii; Kouhei Kawamoto; Kanako Shitomi; Tomokazu Furihata; Kayoko Mayumi; Tsutomu Sugaya
  第61回秋季日本歯周病学会学術大会, 27 Oct. 2018, Japanese, Oral presentation
  [Domestic Conference]
• 北海道大学病院歯科におけるナノシールを用いた根面う蝕進行抑制に関する臨床研究
  宮治裕史; 加藤昭人; 田中佐織
  第15回日本口腔ケア学会総会・学術大会, 29 Apr. 2018, Japanese, Poster presentation
  福岡市, [Domestic Conference]
• A case report that good healing was obtained with priority given to removal of the traumatic force to severe chronic periodontitis with occlusal trauma
  Akihito Kato; Tsutomu Sugaya
  第60回春季日本歯周病学会学術大会, 13 May 2017, Japanese, Poster presentation
  [Domestic Conference]
• バイオミメティック法によるリン酸カルシウム成膜スキャフォールドの特性評価
  西田絵利香; 宮治裕史; 金本佑生実; NATHANAEL A. Joseph; 中村真紀; 大矢根綾子; 村上秀輔; 眞弓佳代子; 加藤昭人; 菅谷勉
  The 16th Congress of the Japanese Society for Regenerative Medicine, 07 Mar. 2017, Japanese, Poster presentation
  [Domestic Conference]
• バイオミメティック法によるリン酸カルシウム成膜スキャフォールドの生物学的特性
  金本佑生実; 宮治裕史; 西田絵利香; NATHANAEL A. Joseph; 中村真紀; 大矢根綾子; 村上秀輔; 眞弓佳代子; 加藤昭人; 菅谷勉
  日本バイオマテリアル学会シンポジウム 2016, 21 Nov. 2016, Japanese, Poster presentation
  [Domestic Conference]
• 咬合性外傷の初期対応を考える
  加藤昭人
  第10回北海道歯周病合同研修会 シンポジウム「咬合性外傷の初期対応」, 06 Nov. 2016, 日本臨床歯周病学会, Japanese, Nominated symposium
  札幌, [Invited], [Domestic Conference]
• 酸化グラフェンと近赤外線光を用いた光熱的抗菌治療法の開発
  Keishi NAGAO; Hirofumi MIYAJI; Erika NISHIDA; Akihito KATO; Tsutomu SUGAYA
  日本歯科保存学会2016年度秋季学術大会（第145回）, 27 Oct. 2016, Japanese, Poster presentation
  [Domestic Conference]
• Deposition of calcium phosphate to the resin surface by laser-assisted biomimetic proces
  Erika NISHIDA; Hirofumi MIYAJI; Joseph NATHANAEL; Maki NAKAMURA; Ayako OYANE; Saori TANAKA; Toru TANAKA; Akihito KATO; Tsutomu SUGAYA
  日本歯科保存学会2016年度秋季学術大会（第145回）, 27 Oct. 2016, Japanese, Poster presentation
  [Domestic Conference]
• ナノシールによる根面う蝕の進行抑制に関する研究
  宮治裕史; 田中佐織; 加藤昭人; 井上加菜; 西尾啓英; 川浪雅光
  第23回日本歯科医学会総会, 22 Oct. 2016, Japanese, Poster presentation
  [Domestic Conference]
• Biomedical Assessment of Titanium coated with Carbon Nanotubes
  Miyaji H; Nishida E; Umeda J; Kondoh K; Takita H; Iizuka T; Akasaka T; Tanaka S; Kato A; Fugetsu B; Sugaya T
  Visual-JW 2016, 18 Oct. 2016, English, Invited oral presentation
  [Invited], [International presentation]
• Acceleration of periodontal healing by implantation of graphene oxide scaffold
  川本康平; 宮治裕史; 加藤昭人; 西田絵利香; 小川幸佑; 舘山彰人; 降籏友和; 宮田さほり; 蔀佳奈子; 菅谷勉
  第59回秋季日本歯周病学会学術大会, 07 Oct. 2016, Japanese, Oral presentation
  新潟コンベンションセンター, [Domestic Conference]
• Priodontal tissue engineering by graphene oxide-collagen scaffold
  Hirofumi MIYAJI; Erika NISHIDA; Kohei KAWAMOTO; Akihito KATO; Tsutomu SUGAYA
  第5回ナノカーボンバイオシンポジウム, 06 Sep. 2016, Japanese, Invited oral presentation
  札幌, [Invited], [Domestic Conference]
• A case report of drug-induced gingival overgrowth in an epilepsy patient who was withdrawn from phenytoin due to epilepsy remission: 12 years’ follow up
  Akihito Kato; Masamitsu Kawanami
  第59回春季日本歯周病学会学術大会, 21 May 2016, Japanese, Poster presentation
  [Domestic Conference]
• Bone forming effect of the scaffold applied with graphene oxide
  Tomokazu FURIHATA; Hirofumi MIYAJI; Erika NISHIDA; Kohei KAWAMOTO; Kosuke OGAWA; Takehito MOMOSE
  第59回春季日本歯周病学会学術大会, 20 May 2016, Japanese, Poster presentation
  かごしま県民交流センター, [Domestic Conference]
• TCPナノ粒子を用いた組織再生用ナノ材料の創製と応用
  宮治裕史; 古月文志; 加藤昭人; 小川幸佑; 村上秀輔; 西田絵利香; 宮田さほり; 川本康平; 滝田裕子; 岩永敏彦; 本郷裕美; 網塚憲生; 川浪雅光
  The 15th Congress of the Japanese Society for Regenerative Medicine, 17 Mar. 2016, Japanese, Poster presentation
  [Domestic Conference]
• 多孔質体を形成するエマルション骨ペーストの開発
  加藤昭人; 宮治裕史; 舘山彰人; 西田絵利香; 岩崎泰彦; 藤井秀司; 滝田裕子; 吉田崇; 小川幸佑; 百瀬赳人; 村上秀輔; 長尾敬志; 川浪雅光
  The 15th Congress of the Japanese Society for Regenerative Medicine, 17 Mar. 2016, Japanese, Poster presentation
  大阪国際会議場, [Domestic Conference]
• Changes in DIAGNOdent values for root caries applied with Nanoseal
  KATO AKIHITO; MIYAJI HIROFUMI; TANAKA SAORI; INOUE KANA; NISHIO TAKAHIDE; KAWANAMI MASAMITSU
  日本歯科保存学会2015年度秋季学術大会（第143回）, 13 Nov. 2015, Japanese, Poster presentation
  [Domestic Conference]
• Bone inductive effect of nano-graphene oxide scaffold for tissue regeneration
  NISHIDA ERIKA; MIYAJI HIROFUMI; TAKITA HIROKO; IWANAGA TOSHIHIKO; KATO AKIHITO; KAWANAMI MASAMITSU
  日本歯科保存学会2015度年秋季学術大会（第143回）, 13 Nov. 2015, Japanese, Poster presentation
  文京シビックホール, [Domestic Conference]
• GlcNAc架橋ゼラチン・キトサンスキャフォールドとFGF‐2による骨新生効果
  YOSHIDA TAKASHI; MIYAJI HIROFUMI; NISHIDA ERIKA; KATO AKIHITO; CHAOCHAI TITIRATTO; FURUIKE TETSUYA; TAMURA YUTAKA; KAWANAMI MASAMITSU
  第37回日本バイオマテリアル学会大会, 10 Nov. 2015, Japanese, Poster presentation
  京都テルサ, [Domestic Conference]
• 酸化グラフェン配合スキャフォールドによる骨増生促進効果
  KAWAMOTO KOHEI; MIYAJI HIROFUMI; YOSHIDA TAKASHI; NISHIDA ERIKA; KATO AKIHITO; TATEYAMA AKITO; TAKITA HIROKO; IWANAGA TOSHIHIKO; KAWANAMI MASAMITSU
  第37回日本バイオマテリアル学会大会, 09 Nov. 2015, Japanese, Poster presentation
  [Domestic Conference]
• TCPナノ粒子配合スキャフォールドの組織再生効果
  宮治裕史; 加藤昭人; 小川幸佑; 西田絵利香; 村上秀輔; 宮田さほり; 川本康平; 滝田裕子; 古月文志; 岩永敏彦
  第11回ナノ・バイオメディカル学会大会, 31 Oct. 2015, Poster presentation
  [Domestic Conference]
• A case report of gingivectomy for the patient with drug-induced gingival overgrowth for 12-years follow up
  Akihito Kato
  第9回北海道歯周病合同研修会, 25 Oct. 2015, 日本臨床歯周病学会, Japanese, Oral presentation
  [Domestic Conference]
• Bioactivity of Chitosan/ Gelatin Scaffold Cross-linked by GlcNAc System
  T. Yoshida; H. Miyaji; E. Nishida; A. Kato; T. Chaochai; T. Furuike; H. Tamura; M. Kawanami
  2015 IADR General Session & Exhibition, 13 Mar. 2015, English, Poster presentation
  [International presentation]
• Biocompatibility of CNT-Ti Composite Surface With Different Nanomorphologies
  E. Nishida; H. Miyaji; J. Umeda; K. Kondoh; H. Takita; B. Fugetsu; S. Tanaka; A. Kato; T. Akasaka; M. Kawanami
  2015 IADR General Session & Exhibition, 13 Mar. 2015, English, Poster presentation
  [International presentation]
• Miyaji H, Nishida E, Umeda J, Kondoh K, Takita H, Fugetsu B, Tanaka S, Kato A, Akasaka T, Kawanami M
  Miyaji H; Nishida E; Umeda J; Kondoh K; Takita H; Fugetsu B; Tanaka S; Kato A; Akasaka T; Kawanami M
  Visual-JW 2014, 26 Nov. 2014, English, Invited oral presentation
  [Invited], [International presentation]
• Biological evaluation of bone paste using particle emulsion of α-TCP and PLGA.
  Akito TATEYAMA; Hirofumi MIYAJI; Akihito KATO; Erika NISHIDA; Yasuhiko IWASAKI; Syuji FUJII; Hiroko TAKITA; Takashi YOSHIDA; Kosuke OGAWA; Takehito MOMOSE; Syusuke MURAKAMI; Keishi NAGAO; Masamitsu KAWANAMI
  第36回バイオマテリアル学会大会, 17 Nov. 2014, Japanese, Poster presentation
  タワーホール船堀, [Domestic Conference]
• イオン徐放性S‐PRGフィラー含有根管シーラーの組織学的検討
  田中佐織; 宮治裕史; 西田絵利香; 井上加菜; 宮田さほり; 川本康平; 村上秀輔; 金山和泉; 加藤昭人; 川浪雅光
  日本歯科保存学会2014年度秋季学術大会（第141回）, 30 Oct. 2014, Japanese, Poster presentation
  [Domestic Conference]
• Effect of nano-β-TCP/collagen scaffold on healing of extraction sockets
  KATO AKIHITO; MIYAJI HIROFUMI; KOSEN YUTA; OGAWA KOSUKE; MOMOSE TAKEHITO; NISHIDA ERIKA; MURAKAMI SYUSUKE; IBARA ASAKO; YOSHIDA TAKASHI; TANAKA SAORI; KAWANAMI MASAMITSU
  日本歯科保存学会2014年度春季学術大会（第140回）, 20 Jun. 2014, Japanese, Poster presentation
  滋賀県立芸術劇場びわ湖ホール, [Domestic Conference]
• Periodontal healing by nano β-TCP scaffold in combination with FGF2
  Kosuke OGAWA; Hirofumi MIYAJI; Akihito KATO; Yuta KOSEN; Takehito MOMOSE; Takashi YOSHIDA; Syusuke MURAKAMI; Erika NISHIDA; Masamitsu KAWANAMI
  第57回春季日本歯周病学会学術大会, 24 May 2014, Japanese, Oral presentation
  [Domestic Conference]
• Periodontal healing following implantation of FGF2-loaded collagen hydrogel scaffold in class II furaction defects in dogs
  Takehito MOMOSE; Hirofumi MIYAJI; Akihito KATO; Yuta KOSEN; Kosuke OGAWA; Asako IBARA; Takashi YOSHIDA; Syusuke MURAKAMI; Erika NISHIDA; Tsutomu SUGAYA; Masamitsu KAWANAMI
  第57回春季日本歯周病学会学術大会, 24 May 2014, Japanese
• Preparation and biological evaluation of titanium coated with CNT-ne
  E Nishida; H Miyaji; H Takita; J Umeda; K Kondoh; B Fugetsu; S Tanaka; A Kato; I Kanayama; M Kawanami
  The 13th Congress of the Japanese Society for Regenerative Medicine, 05 Mar. 2014, Japanese, Poster presentation
  [Domestic Conference]
• 新規イオン徐放性S‐PRGフィラー含有根管シーラーの生体適合性の検討
  田中佐織; 宮治裕史; 西田絵利香; 金山和泉; 加藤昭人; 中塚稔之; 川浪雅光
  日本歯科保存学会2013年度春季学術大会（第138回）, 28 Jun. 2013, Japanese, Poster presentation
  [Domestic Conference]
• Periodontal healing following implantation of FGF2 loaded collagen hydrogel/sponge scaffold in class II furcation defects in dogs
  Takehito MOMOSE; Hirofumi MIYAJI; Akihito KATO; Yuta KOSEN; Kosuke OGAWA; Asako IBARA; Takashi YOSHIDA; Tsutomu SUGAYA; Masamitsu KAWANAMI
  第56回春季日本歯周病学会学術大会, 01 Jun. 2013, Japanese, Poster presentation
  [Domestic Conference]
• Application of nano β-TCP/collagen scaffold to periodontal defects in dogs
  Kosuke OGAWA; Hirofumi MIYAJI; Akihito KATO; Yuta KOSEN; Takashi YOSHIDA; Takehito MOMOSE; Erika NISHIDA; Shusuke MURAKAMI; Masamitsu KAWANAMI
  第56回春季日本歯周病学会学術大会, 01 Jun. 2013, Japanese, Poster presentation
  [Domestic Conference]
• カーボンナノチューブコーティングチタンの生体応用
  MIYAJI HIROFUMI; NISHIDA ERIKA; TANAKA SAORI; UMEDA JUNKO; KONDO KATSUYOSHI; FUGETSU BUNSHI; KANAYAMA IZUMI; KATO AKIHITO; KAWANAMI MASAMITSU
  日本バイオマテリアル学会シンポジウム予稿集, 26 Nov. 2012, Japanese, Poster presentation
  [Domestic Conference]
• 日本歯周病学会および日本歯科保存学会認定医・専門医取得のために，歯周病学会認定医について～制度紹介と申請症例～
  加藤昭人
  第37回北海道歯周病研究会, 12 Oct. 2012, Japanese, Nominated symposium
  [Domestic Conference]
• Preparation and biological evaluation of titanium coated with CNT-net
  E Nishida; H Miyaji; J Umeda; K Kondoh; B Fugetsu; S Tanaka; A Kato; I Kanayama; M Kawanami
  98th Annual Meeting of AAP, 29 Sep. 2012, English, Poster presentation
  Los Angels, [International presentation]
• The bone-forming effect of nano-β-TCP/collagen scaffold
  A Kato; H Miyaji; Y Kosen; K Ogawa; T Momose; B Fugetsu; A Ibara; T Yoshida; S Tanaka; M Kawanami
  98th Annual Meeting of AAP, 29 Sep. 2012, English, Poster presentation
  [International presentation]
• 高気孔性β‐TCPスキャフォールドの作製と評価
  宮治裕史; 吉田崇; 光銭裕太; 大谷香織; 井上加菜; 井原朝子; 金山和泉; 加藤昭人; 田中佐織; 川浪雅光
  日本歯周病学会学術大会プログラムおよび講演抄録集, 18 May 2012, Japanese, Poster presentation
  [Domestic Conference]
• Periodontal regeneration following root surface BMP-conditioning
  加藤昭人; 宮治裕史; 石塚良介; 得永佳介; 井上加菜; 光銭裕太; 横山裕之; 田中佐織; 菅谷勉; 川浪雅光
  第53回日本歯周病学会秋季学術大会, 19 Sep. 2010, Japanese, Poster presentation
  [Domestic Conference]
• Periodontal regeneration following BMP-root conditioning and collagen scaffold implantation
  KATO,A MIYAJI; H ISHIZUKA; R; TOKUNAGA; K INOUE; K KOSEN; Y YOKOYAMA; H TANAKA; S SUGAYA; T; KAWANAMI,M
  2010 IADR General Session & Exhibition, 14 Jul. 2010, English, Poster presentation
  Barcelona, [International presentation]
• 根分岐部classII骨欠損におけるコラーゲンハイドロゲル‐スポンジ複合体による歯周組織再生
  光銭裕太; 宮治裕史; 加藤昭人; 横山裕之; 逸見優; 小林尚子; 石塚良介; 田中佐織; 菅谷勉; 川浪雅光
  第53回日本歯周病学会春季学術大会, 14 May 2010, Japanese, Oral presentation
  [Domestic Conference]
• Periodontal Regeneration by Collagen Hydrogel-sponge Composite in 1-wall infrabony defects
  加藤昭人; 宮治裕史; 光銭裕太; 横山裕之; 石塚良介; 得永佳介; 井上加菜; 逸見優; 田中佐織; 菅谷勉; 川浪雅光
  第53回日本歯周病学会春季学術大会, 14 May 2010, Japanese, Poster presentation
  [Domestic Conference]
• 根分岐部class II骨欠損にコラーゲンハイドロゲル‐スポンジ複合体を移植した場合の組織反応
  光銭裕太; 宮治裕史; 加藤昭人; 横山裕之; 逸見優; 小林尚子; 石塚良介; 田中佐織; 菅谷勉; 川浪雅光
  he Japanese Conservative Dentistry 2009 Autumn meeting, 30 Oct. 2009, Japanese, Poster presentation
  [Domestic Conference]
• コラーゲンハイドロゲル‐スポンジ複合体を頭蓋骨に移植した場合のスキャフォールドとしての有効性とBMP併用による骨増生
  得永佳介; 宮治裕史; 石塚良介; 加藤昭人; 井上加菜; 逸見優; 光銭裕太; 玉川博貴; 菅谷勉; 川浪雅光
  第52回日本歯周病学会春季学術大会, 15 May 2009, Japanese, Oral presentation
  [Domestic Conference]
• 象牙質表面へのBMP‐2とコラーゲンハイドロゲルの塗布による歯槽骨再生と骨性癒着
  石塚良介; 宮治裕史; 加藤昭人; 得永佳介; 井上加菜; 田中陽; 菅谷勉; 川浪雅光
  第7回日本再生医療学会総会, 14 Mar. 2008, Japanese, Poster presentation
  [Domestic Conference]
• Periodontal regeneration by BMP-2 application to root surface in 1-wall infrabony defects
  Akihito Kato
  平成19年度北海道歯学会秋季学術大会, 22 Nov. 2007, Japanese, Oral presentation
  [Domestic Conference]
• BMP-2 application to root surface enhances periodontal regeneration in 1-wall infrabony defects
  加藤昭人; 宮治裕史; 石塚良介; 得永佳介; 井上加菜; 菅谷勉; 川浪雅光
  The Japanese Conservative Dentistry 2007 Autumn meeting, 09 Nov. 2007, Japanese, Oral presentation
  [Domestic Conference]
• 歯根象牙質表面へのBMP‐2とコラーゲンハイドロゲルの塗布が歯周組織再生を高める
  石塚良介; 宮治裕史; 伊部敬介; 加藤昭人; 得永佳介; 井上加菜; 田中陽; 菅谷勉; 川浪雅光
  第49回日本歯周病学会秋季学術大会, 21 Oct. 2006, Japanese, Oral presentation
  [Domestic Conference]
• Epithelial down growth and width of resin in contact with periodontal tissue after bonding treatment of vertical root fracture
  MOTOKI Youji; SUGAYA Tsutomu; TOMITA Mahito; KAWAMURA Naohito; KATOU Akihito; KAWANAMI Masamitsu
  日本歯科保存学会2005年度秋季学術大会（第123回）, 31 Oct. 2005, Japanese, Oral presentation
  [Domestic Conference]

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• 歯周組織再建学研究Ⅰ, 2024年, 博士後期課程, 歯学院
• 歯周組織再建学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅰ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅲ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅴ, 2024年, 博士後期課程, 歯学院
• 基本技法, 2024年, 博士後期課程, 歯学院
• 基本技術実習, 2024年, 学士課程, 歯学部
• 歯周病学・歯内療法学臨床実習Ⅰ, 2024年, 学士課程, 歯学部
• 歯周病学・歯内療法学臨床実習Ⅱ, 2024年, 学士課程, 歯学部

• The Japanese Society of Conservative Dentistry
• The Japanese Society of Periodontology

• Photo-regenerative therapy - biomimetic cementum construction on periodontal root surfaces by laser irradiation
  Grants-in-Aid for Scientific Research
  Apr. 2023 - Mar. 2026
  加藤 昭人,大矢根 綾子,宮治 裕史,田中 佐織,金本 佑生実
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, 23K11821
• S-PRGフィラー含有仮封材のイオン徐放性ならびに抗菌効果の検討
  受託研究
  Apr. 2022 - Mar. 2024
  宮治 裕史; 加藤 昭人
  株式会社 松風, Coinvestigator
• 歯周病光殺菌治療のための光感応性キトサンナノゲル剤の開発
  札幌ライフサイエンス産業活性化事業
  Aug. 2022 - Mar. 2023
  加藤 昭人; 小野寺 真也; 中島 愛梨; 渡邊 弓; 宮治 裕史; 長谷部 晃; 網塚 憲生
  ノーステック財団, 事業化支援補助金, Principal investigator, Competitive research funding
• S-PRGナノフィラー分散液（S-PRGバイオクリーニングリキッド）を用いた超音波洗浄効果について
  受託研究
  Nov. 2020 - Mar. 2023
  宮治 裕史,加藤 昭人
  株式会社 松風, Coinvestigator, Others
• 光殺菌と組織再生効果を併せ持つ新しい歯周病治療用ゲル剤の開発
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  Apr. 2019 - Mar. 2022
  Kato Akihito
  Antimicrobial photodynamic therapy (a-PDT) is a treatment method that uses light irradiation and singlet oxygen generated by a photosensitizer to kill bacteria. In this study,gold and silver nanoclusters of photosensitizers and rose bengal nanogels containing chitosan, a cationic polymer, were prepared and their photodynamic properties were investigated. The photodynamic properties of the nanogels were investigated, and their antibacterial and antibiofilm properties and cytotoxicity were also evaluated.The results suggest that a-PDT using white LED irradiation may be effective against oral biofilm infections.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, 19K10102
• ナノS-PRGフィラー分散液を用いた超音波スケーラー注水システムによる新規歯周病治療予防法の確立
  共同研究
  Nov. 2019 - Mar. 2021
  宮治 裕史,加藤 昭人
  株式会社 松風, Coinvestigator, Industry academia cooperation
• 新規歯科用材料の生物学的特性評価
  共同研究
  Apr. 2018 - Mar. 2020
  宮治 裕史,加藤 昭人
  日本歯科薬品株式会社, Competitive research funding
• 新規根管充填用シーラーの開発
  共同研究
  Sep. 2017 - Mar. 2020
  宮治 裕史,加藤 昭人
  昭和薬品化工株式会社, Competitive research funding
• ひまし油を用いたエマルションスキャフォールドの創製とペースト状骨補填材への応用
  研究助成
  May 2018 - Mar. 2019
  加藤 昭人
  公益信託 伊藤徳三ひまし研究基金, Principal investigator, Competitive research funding
• 新規歯科治療用材料の抗菌性評価
  共同研究
  Apr. 2018 - Mar. 2019
  宮治 裕史,加藤 昭人
  株式会社 松風, Coinvestigator, Industry academia cooperation
• 歯周病再生用骨補填材の開発
  橋渡し研究加速ネットワークプログラムシーズA
  Apr. 2017 - Mar. 2019
  宮治 裕史,加藤 昭人
  文部科学省, Competitive research funding
• Create periodontal tissue formation on composite resin! for improvement of reliability of bonding treatment
  Grants-in-Aid for Scientific Research
  Apr. 2016 - Mar. 2019
  TANAKA SAORI; OYANE AYAKO; NAKAMURA MAKI; Nathanael AJ; KATO AKIHITO; MIYATA SAORI; MAYUMI KAYOKO
  Composite resin (CR) is applied as a bonding treatment and as a root perforation. However, CR surface rarely reconstructs periodontal attachment apparatus.
  The laser-assisted biomimetic (LAB) process.This may improve the biocompatibility of CR through the surface modification. This study aimed to develop a technique to produce the osteoconductive resin surfaces through calcium phosphate (CaP) coating using LAB process.
  The LAB-processed substrate was immersed for 3 days in a simulated body fluid (SBF) for the preliminary osteoconductivity assessment.According to the results of the microscopic observation and the EDX analysis, nano- and micro-structured CaP layers were formed on the CR surfaces, after the LAB process. Thus,this study might suggest a possibility of the periodontal tissue formation on CR.The LAB process is a potential new tool to create a cementum-like osteoconductive surface on dental composite resins.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 16K11538
• Fabrication and application of nanomaterial using biomineralization method for periodontal tissue engineering
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  Apr. 2016 - Mar. 2019
  Miyaji Hirofumi; OYANE Ayako
  We fabricated the nano-structured apatite scaffold using biomineralization method to imitate the bone formation in the body. The evaluation of biocompatibility, bone inductive effect and periodontal regenerative activity of apatite scaffold were carried out. In addition, we obtained the apatite scaffold loaded with fibroblast growth factor-2 (FGF2) to enhance the bio-properties of scaffold and assessed the bone forming ability.
  The results showed that apatite scaffold exhibited high biocompatibility and bone forming effect in rat cranial bone defect. Apatite scaffold stimulated the periodontal regeneration in class II furcation defect in beagle dogs. In addition, FGF-2 loaded apatite scaffold remarkably promoted the bone augmentation of rat skull bone, compared to pristine apatite scaffold. The nano-structured apatite scaffold would be beneficial for medical application in bone and periodontal tissue engineering.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 16K11822
• S-PRGフィラー組成物による歯周炎改善効果の検討
  共同研究
  Dec. 2016 - Mar. 2018
  宮治 裕史; 田中 佐織; 西田 絵利香,加藤 昭人
  株式会社 松風, Coinvestigator, Industry academia cooperation
• 新型骨補填材の骨再生効果の研究
  共同研究
  Dec. 2015 - Mar. 2017
  宮治 裕史,加藤 昭人
  昭和薬品化工株式会社, Competitive research funding
• S-PRGフィ ラー含有シーラーのin vivo 前臨床的評価
  共同研究
  Apr. 2014 - Mar. 2017
  宮治 裕史,加藤 昭人
  株式会社松風, Competitive research funding
• Application of emulsion bone paste forming porous structure to periodontal treatment
  Grants-in-Aid for Scientific Research
  Apr. 2014 - Mar. 2017
  KATO Akihito; NISHIDA Erika; TATEYAMA Akito
  We developed bone paste using particle emulsion of α-Tricalcium phosphate (α-TCP) and Poly(lactic-co-glycolic) acid (PLGA), and evaluated the ability as bone regeneration material in vivo and in vitro. As a result, emulsion bone paste showed good biocompatibility in vivo, and more cell invasion into the material was observed by PLGA addition. If this new bone paste can be applied to periodontal disease, it is expected that a large amount of cells in the surrounding will invade the material, and it will be possible to obtain the effect of regeneration over conventional bone graft material.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, Principal investigator, Competitive research funding, 26870016
• 歯周病による重度組織破壊を再生する新規骨ペースト材の開発
  若手研究人材育成事業
  Jul. 2015 - Mar. 2016
  加藤 昭人
  ノーステック財団, Principal investigator, Competitive research funding
• 歯周病治療用材料の開発
  橋渡し研究加速ネットワークプログラムシーズA
  Apr. 2015 - Mar. 2016
  宮治 裕史,加藤 昭人
  文部科学省, Competitive research funding
• A development of the bonding treatment of vertically fractured roots with periodontal regeneration on adhesive resin using nanotechnology
  Grants-in-Aid for Scientific Research
  Apr. 2013 - Mar. 2016
  TANAKA SAORI; MIYAJI HIROFUMI; INOUE KANA; TANAKA TORU; TANINO MISHIE; KATO AKIHITO; KANAYAMA IZUMI; NISHIDA ERIKA; MURAKMI SHUSUKE; KAWAMOTO KOHEI; MIYATA SAORI
  Composite resin (CR) is used the bonding treatment of vertically fractured roots and as a retrograde material following apiccectomy. We aimed to the periodontal regeneration on CR. Effective biological modification of the CR surface is thus needed to improve its biocompatibility. Carbon nanotubes (CNT) and β-TCP have useful properties such as promoting cell adhesion and proliferation. CR discs were coated by immersion in a dispersion of CNT and β-TCP. In the cell culture assay, the CNT-CR samples exhibited abundant cells and marked adhesion of filopodia to CNT. Cell proliferation assay indicated that the CNT-CR was significantly higher than the CR . This results showed that coating the surface of CR with CNT improved their biocompatibility. In vivo studies, we observed the bone-like hard tissue formation on a CNT-CR wrapped in cultured bone marrow stromal cell sheets. Thus, this experiment might suggest a possibility of the periodontal regeneration on CR.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 25462943
• Novel periodontal therapy using nanocarbon coating procedure
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  Apr. 2013 - Mar. 2016
  Miyaji Hirofumi; TANAKA SAORI; KATO AKIHITO; FUGETSU BUNSHI; NISHIDA ERIKA
  Biocompatibility tests were performed to evaluate the biological properties of nanocarbon materials, such as graphene oxide (GO) and carbon nanotube (CNT). In addition, tooth coating procedure using GO and regenerative scaffold including GO were developed for application to periodontal therapy. Low dose of GO and CNT consistently exhibited good biocompatibility, in particular, CNT stimulated cell proliferative activity. The tooth coating procedure using GO solution provided the antimicrobial effect to the tooth surface. GO scaffold exhibited cytocompatibility and promoted tissue healing and bone formation when implanted in tooth extraction socket or furcation periodontal defect in dog. Consequently, nanocarbon materials would be available for medical application in periodontal therapy.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 25463210
• 新規歯面コーティング法の開発
  橋渡し研究加速ネットワークプログラムシーズA
  Apr. 2014 - Mar. 2015
  宮治 裕史,加藤 昭人
  文部科学省, Competitive research funding
• Periodontal regeneration by collagen scaffold in combination with FGF-2
  Grants-in-Aid for Scientific Research
  Apr. 2011 - Mar. 2014
  KATO Akihito
  We examined whether combined therapy of fibroblast growth factor 2 (FGF-2) induced wound healing and collagen hydrogel scaffold stimulated periodontal regeneration. Collagen hydrogel scaffold has rapid cell infiltration in the scaffold and replacement by regenerative tissue with low cytotoxicity. Implantation of collagen hydrogel scaffold in combination with FGF-2 enhanced regeneration of alveolar bone, cementum, periodontal ligament in beagle dogs. The combined therapy is expected to be a suitable therapy for periodontal tissue engineering.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, Principal investigator, Competitive research funding, 23792266
• Periodontal tissue engineering using osteoconductive scaffold coated by nano bioceramics.
  Grants-in-Aid for Scientific Research
  2010 - 2012
  MIYAJI Hirofumi; FUGETSU Bunshi; TANAKA Saori; KATO Akihito
  Nanoparticle bioceramics have many bioactive effects. We prepared collagen scaffold coated by nano tricalcium phosphate (TCP) and growth factor and evaluated the effects on tissue engineering. Nano-TCP scaffold showed higher compressive strength, cyto-compatibility and tissue ingrowth. In histological evaluations, bone augmentation and periodontal tissue healing were stimulated by application of nano-TCP scaffold in combination with fibroblast growth factor-2 (FGF2). We concluded that FGF2/nano-TCP scaffold would be effective for bone and periodontal tissue engineering.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 22791916
• A development of the bonding treatment of vertically fractured roots with periodontal regeneration adhesive resin using tissue engineering
  Grants-in-Aid for Scientific Research
  2010 - 2012
  TANAKA Saori; SUGAYA Tsuomu; MIYAJI Hirofumi; SHIMOJI Shinnji; YOSHIMURA Yoshitaka; TANAKA Toru; OTANI Kaori; INOUE Kana; FUKUDA Hiroe; IBARA Asako; KANAYAMA Izumi; MOMOSE Takehito; NUSHIDA Erika; MIYATA Saori
  To enhance the bonding treatment of vertically fractured roots, we aimed to the newly cementum formation on a compound of resin and dentin powder, or β-TCP which may improve the binding between resin and cementum. In vitro, cytotoxicity was assessed. It had little cytotoxicity. In vivo, we observed the newly hard tissue formation on a resin containing β-TCP applied by rhBMP-2 and cultured bone marrow stromal cell sheets. This experiment might exhibit a possibility of the newly hard tissue formation on a resin.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 22592108
• 歯根表面へのBMP-2塗布とコラーゲンハイドロゲル-スポンジ複合体の併用による歯周組織再生
  海外学会等出席研究交流助成
  Jul. 2010 - Jul. 2010
  加藤 昭人
  伊藤医薬学術交流財団, Principal investigator, Competitive research funding
• A development of the bonding treatment of vertically fractured roots with cementum regeneration on 4-META/MMA-TBB resin
  Grants-in-Aid for Scientific Research
  2007 - 2009
  TANAKA Saori; SUGAYA Tsutomu; MIYAJI Hirofumi; KATO Akihito; YOSHIMURA Yoshitaka; IBE Yuko; TENKUMO Taichi; OTANI Kaori; NAKATSUKA Megumi; INOUE Kana; FUKUDA Hiroe; HENMI Masaru; KOSEN Yuta; TAMAGAWA Hiroki; HONMA Keishi; YOKOYAMA Hiroyuki; WASHIZU Taro; KANAYAMA Izumi; SUNOSAKI Maki; NAKAZAWA Atsushi
  To improve the bonding treatment of vertically fractured roots, we aimed to the newly cementum formation on a compound of resin and dentin powder, which may improve the binding between resin and cementum. In vitro, cytotoxicity and Micro Tensile Bond Strength (MTBS) test were assessed. It had little cytotoxicity and exhibited higher bond strength. In vivo, in some cases, we observed the newly cementum formation on a compound of resin and dentin powder. This experiment might exhibit a possibility of the newly cementum formation on a resin.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 19592191