Ph.D. of Engineering, The University of Tokyo, Mar. 2015

高分子電解質

Quasi-elastic neutron scattering

高分子物理

静的・動的光散乱

小角X線散乱

小角中性子散乱

高分子ゲル

高分子溶液

Nanotechnology/Materials, Polymer materials, ソフトマター

Bachelor's degree program, School of Science

Master's degree program, Graduate School of Life Science

Doctoral (PhD) degree program, Graduate School of Life Science

Aug. 2026, 北海道大学, エクセレントティーチャーズ
全学教育科目

May 2024, 北海道大学, ディスティングイッシュトリサーチャー（卓越研究者）称号付与
Li Xiang, Others

Mar. 2024, 日本中性子科学会, 奨励賞
Li Xiang, Japan society, Japan

Apr. 2023, 文部科学省, 文部科学大臣表彰 若手科学者賞
『パーコレーション理論に基づく超均一ゲル開発に関する研究』
Li Xiang, Others, Japan

Mar. 2021, Institute for Solid State Physics, The University of Tokyo, ISSP Young Scientist Medal

Feb. 2020, 江野科学振興財団, 田中ゴム科学技術賞

May 2019, 高分子学会, 高分子研究奨励賞

Nov. 2016, Asia-Oceania Neutron Scattering Association, AONSA Young Research Fellowship 2017

Dec. 2014, 14th Asia-Pacific International Symposium on Microscale Separations and Analysis, Best Poster Awards

Nov. 2014, Polymer Network Groups Meeting and Gel Symposium 2014, Best Poster Awards

Jan. 2014, 高分子ゲル研究討論会, 優秀演題賞

Mar. 2013, 29th International Symposium on MicroScale Bioseparations, Students Travel Awards

Nov. 2012, 第32回キャピラリー電気泳動シンポジウム, 最優秀ポスター賞

Oct. 2012, 9th International Gel Symposium, Presentation Awards for Young Researchers

Jan. 2011, 帝人21世紀フォーラム, 最優秀発表賞

Heteroaggregation of Antimicrobial Peptides LL-37 and HNP-1 Drives Cooperative Neutralization of Cytotoxicity
Jing Zhang; Yuge Hou; Takashi Yasuda; Siu Yu A. Chow; Soshi Ito; Mizuho Otsuka; Yoshiho Ikeuchi; Xiang Li; Kaori Sugihara
JACS Au, American Chemical Society (ACS), 20 Feb. 2026, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
Scientific journal

Single Amino Acid Modulates Antimicrobial Peptide Cooperativity between LL-37 and HNP1
Ariane M. Schwitter; Takashi Yasuda; Xiang Li; Kaori Sugihara
Langmuir, 42, 3, 2423, 2430, American Chemical Society (ACS), 15 Jan. 2026, [Peer-reviewed], [International Magazine]
Scientific journal

Preparation of Polymer Gel with Homogeneous Network Structure Composed of Photoreactive Star-Shaped N -Isopropylacrylamide Polymers
Yuria Otsuka; Ikuya Ohshima; Mitsuo Hara; Takahiro Seki; Taiki Hoshino; Masashi Ohira; Xiang Li; Yukikazu Takeoka
Macromolecules, American Chemical Society (ACS), 09 Dec. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
Scientific journal

Aromatic Residues Drive Polyelectrolyte Coacervates into Hydrogels for Underwater and Underoil Adhesion
Zhili Zhang; Yonglin He; Ting Wang; Xiaoyuan Wang; Hongguang Liao; Misaki Sawada; Xiang Li; Hailong Fan; Jian Ping Gong
Macromolecules, American Chemical Society (ACS), 30 Sep. 2025, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
Scientific journal

Rheological and thermal behaviour of microtubule networks mediated by microtubule associated proteins
Syeda Rubaiya Nasrin; Masashi Ohira; Kousuke Matsumura; Tomomi Tani; Kiyotaka Tokuraku; Kazuki Sada; Mitsuhiro Shibayama; Xiang Li; Akira Kakugo
Soft Matter, 21, 34, 6771, 6778, Royal Society of Chemistry (RSC), Aug. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
Scientific journal, Microtubule-associated proteins differentially organize microtubule networks, leading to distinct structural and mechanical properties that may influence cytoskeletal function under physiological conditions.

Adsorption suppression and viscosity transition in semidilute PEO/silica nanoparticle mixtures under the protein limit
Saki Kusakabe; Xiang Li; Koichi Mayumi; Takuya Katashima; Ichiro Sakuma; Yuki Akagi
Journal of Colloid and Interface Science, 137377, 137377, Elsevier BV, Mar. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
Scientific journal

Fatigue Behaviors of Anisotropic Hydrogels with a Macroscopic Lamellar Bilayer Structure and Swelling Effects
Most Laboni Begum; Milena Lama; Wenqi Yang; Xiang Li; Md. Anamul Haque; Xueyu Li; Jian Ping Gong
Macromolecules, 57, 23, 10948, 10963, American Chemical Society (ACS), 26 Nov. 2024, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
Scientific journal

Tuning network structures of hydrophobic hydrogels by controlling polymerization solvent
Hailong Fan; Daito Naohara; Wei Li; Xiang Li; Jian Ping Gong
Polymer Chemistry, 15, 20, 2104, 2111, Royal Society of Chemistry (RSC), 02 May 2024, [Peer-reviewed], [International Magazine]
Scientific journal, Hydrophobic hydrogels with various copolymer sequences and network structures are prepared by tuning the solvent condition of the reaction solution, which exhibit different appearance and properties under the same monomer composition.

Humidity responsiveness of a poly(N-isopropylacrylamide) gel with a PEG/water mixed solvent
Ryotaro Makita; Aya M. Akimoto; Takafumi Enomoto; Taihei Nishimoto; Xiang Li; Mitsuhiro Shibayama; Ryo Yoshida
Polymer Journal, 56, 6, 639, 642, Springer Science and Business Media LLC, 28 Feb. 2024, [Peer-reviewed], [International Magazine]
Scientific journal

Strain-Induced Crystallization in Tetra-Branched Poly(ethylene glycol) Hydrogels with a Common Network Structure
Kei Hashimoto; Takato Enoki; Chang Liu; Xiang Li; Takamasa Sakai; Koichi Mayumi
Macromolecules, 57, 4, 1461, 1468, American Chemical Society (ACS), 12 Feb. 2024, [Peer-reviewed], [International Magazine]
Scientific journal

Percolation-induced gel–gel phase separation in a dilute polymer network
Shohei Ishikawa; Yasuhide Iwanaga; Takashi Uneyama; Xiang Li; Hironori Hojo; Ikuo Fujinaga; Takuya Katashima; Taku Saito; Yasushi Okada; Ung-il Chung; Naoyuki Sakumichi; Takamasa Sakai
Nature Materials, 22, 12, 1564, 1570, Springer Science and Business Media LLC, 30 Oct. 2023, [Peer-reviewed], [International Magazine]
Scientific journal

Molecular Insights into Photochemical Hydrogen Evolution Dual Catalysis within the Shell of Polymer Micelle-Based Nanoreactors
Takafumi Enomoto; Yui Tsuji; Xiang Li; Aya M. Akimoto; Ryo Yoshida
ACS Applied Nano Materials, 6, 12, 10078, 10086, American Chemical Society (ACS), 01 Jun. 2023, [Peer-reviewed], [International Magazine]
Scientific journal

Miscibility and ternary diagram of aqueous polyvinyl alcohols with different degrees of saponification.
Junhyuk Kim; Shohei Ishikawa; Mitsuru Naito; Xiang Li; Ung-Il Chung; Takamasa Sakai
Scientific reports, 13, 1, 8791, 8791, 31 May 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, Liquid-liquid phase separation (LLPS), an important phenomenon in the field of polymer science and material design, plays an essential role in cells and living bodies. Poly(vinyl alcohol) (PVA) is a popular semicrystalline polymer utilized in the synthesis of artificial biomaterials. The aqueous solutions of its derivatives with tuned degrees of saponification (DS) exhibit LLPS. However, the miscibility and LLPS behavior of PVA aqueous solution are still unclear. This study describes the miscibility diagram of the ternary mixture, where water and two types of poly(vinyl alcohol) (PVA) with different DSs [98 (PVA98), 88 (PVA88), 82 (PVA82), and 74 mol% (PVA74)] were blended. UV-Vis measurement was conducted to evaluate the miscibility. Immiscibility was more pronounced at elevated temperatures, exhibiting LLPS. The ternary immiscibility diagram, displaying miscible-immiscible behaviors in the aqueous mixtures of PVA74:PVA98, PVA82:PVA98, and PVA88:PVA98 (blended at a constant volume ratio), indicated that increasing the concentration, temperature, and blend ratio of PVAs at a lower DS increased immiscibility, suggesting that the free energy of mixing increases with increasing these parameters. The miscible-immiscible behaviors of PVAs/water systems provide fundamental knowledge about LLPS and the design of PVA-based materials.

Effects of network junctions and defects on the crystallization of model poly(ethylene glycol) networks
Masashi Ohira; Shintaro Nakagawa; Ryotaro Sampei; Takako Noritomi; Takamasa Sakai; Mitsuhiro Shibayama; Xiang Li
Soft Matter, 19, 8, 1653, 1663, Royal Society of Chemistry (RSC), 24 Jan. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
Scientific journal, While junction points drastically delay the crystallization of polymeric materials, network defects affect little.

Non-swellability of polyelectrolyte gel in divalent salt solution due to aggregation formation
Jian Tang; Takuya Katashima; Caidric Indaya Gupit; Xiang Li; Yoshiro Mitsukami; Yuki Yokoyama; Naoyuki Sakumichi; Ung-il Chung; Mitsuhiro Shibayama; Takamasa Sakai
Polymer, 250, 124894, 124894, Elsevier BV, May 2022, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
Scientific journal

Star-Polymer-DNA Gels Showing Highly Predictable and Tunable Mechanical Responses.
Masashi Ohira; Takuya Katashima; Mitsuru Naito; Daisuke Aoki; Yusuke Yoshikawa; Hiroki Iwase; Shin-Ichi Takata; Kanjiro Miyata; Ung-Il Chung; Takamasa Sakai; Mitsuhiro Shibayama; Xiang Li
Advanced materials, 34, 13, e2108818, 2108818, Wiley, Apr. 2022, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
English, Scientific journal, Dynamically crosslinked gels are appealing materials for applications that require time-dependent mechanical responses. DNA duplexes are ideal crosslinkers for building such gels because of their excellent sequence addressability and flexible tunability in bond energy. However, the mechanical responses of most DNA gels are complicated and unpredictable. Here, a DNA gel with a highly homogeneous gel network and well predictable mechanical behaviors is demonstrated by using a pair of star-polymer-DNA precursors with presimulated DNA sequences showing the two-state transition. The melting curve analysis of the DNA gels reveals the good correspondence between the thermodynamic potentials of the DNA crosslinkers and the presimulated values by DNA calculators. Stress-relaxation tests and dissociation kinetics measurements show that the macroscopic relaxation time of the DNA gels is approximately equal to the lifetime of the DNA crosslinkers over 4 orders of magnitude from 0.1-2000 s. Furthermore, a series of durability tests find the DNA gels are hysteresis-less and self-healable after the applications of repeated temperature and mechanical stimuli. These results demonstrate the great potential of star-polymer-DNA precursors for building gels with predictable and tunable viscoelastic properties, suitable for applications such as stress-response extracellular matrices, injectable solids, and soft robotics.

Nanoscale Structures of Poly(oligo ethylene glycol methyl ether methacrylate) Hydrogels Revealed by Small-Angle Neutron Scattering
Takuma Kureha; Masashi Ohira; Yuki Takahashi; Xiang Li; Elliot P. Gilbert; Mitsuhiro Shibayama
Macromolecules, 55, 5, 1844, 1854, 23 Feb. 2022, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
Scientific journal

Structure and Dynamics of Critical Polymer Clusters Formed with Tetra-Armed Star-Polymers
Xiang Li
Nihon Reoroji Gakkaishi, 50, 1, 113, 117, Society of Rheology Japan, 15 Feb. 2022, [Peer-reviewed], [Invited], [Lead author, Corresponding author], [International Magazine]
English, Scientific journal

Construction of a nano-phase-separated structure on a hydrogel surface
Taihei Nishimoto; Takafumi Enomoto; Chia Hsuan Lin; Jhih Guang Wu; Caidric Indaya Gupit; Xiang Li; Shyh Chyang Luo; Aya Mizutani Akimoto; Ryo Yoshida
Soft Matter, 18, 4, 722, 725, Royal Society of Chemistry (RSC), 28 Jan. 2022, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
Scientific journal

Topology Transformation toward Cyclic, Figure-Eight-Shaped, and Cross-Linked Polymers Based on the Dynamic Behavior of a Bis(hindered amino)disulfide Linker
Hirogi Yokochi; Masashi Ohira; Minami Oka; Satoshi Honda; Xiang Li; Daisuke Aoki; Hideyuki Otsuka
Macromolecules, 54, 21, 9992, 10000, 09 Nov. 2021, [Peer-reviewed], [International Magazine]
Scientific journal

Microphase separation of stimuli-responsive interpenetrating network microgels investigated by scattering methods
Elena Yu. Kozhunova; Vladimir Yu. Rudyak; Xiang Li; Mitsuhiro Shibayama; Georgy S. Peters; Oxana V. Vyshivannaya; Irina R. Nasimova; Alexander V. Chertovich
Journal of Colloid and Interface Science, 597, 297, 305, Elsevier BV, Sep. 2021, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
Scientific journal

A benchmark for gel structures: bond percolation enables the fabrication of extremely homogeneous gels
Xiang Li
Polymer Journal, 53, 7, 765, 777, Jul. 2021, [Peer-reviewed], [Invited], [Lead author, Last author, Corresponding author], [International Magazine]
Scientific journal

Neutralization and Salt Effect on the Structure and Mechanical Properties of Polyacrylic Acid Gels under Equivolume Conditions
Yui Tsuji; Mitsuhiro Shibayama; Xiang Li
Gels, 7, 2, 69, 69, 09 Jun. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal

Molecular crystallization directed by polymer size and overlap under dilute and crowded macromolecular conditions
Yuuki Hata; Xiang Li; Ung-il Chung; Takamasa Sakai
Polymer Journal, 53, 5, 633, 642, May 2021, [Peer-reviewed], [International Magazine]
Scientific journal

Effect of Nonlinear Elasticity on the Swelling Behaviors of Highly Swollen Polyelectrolyte Gels
Jian Tang; Takuya Katashima; Xiang Li; Yoshiro Mitsukami; Yuki Yokoyama; Ung-il Chung; Mitsuhiro Shibayama; Takamasa Sakai
Gels, 7, 1, 25, 25, 01 Mar. 2021, [Peer-reviewed], [International Magazine]
Scientific journal

Mechanical properties of temperature-responsive gels containing ethylene glycol in their side chains
Takuma Kureha; Kyohei Hayashi; Xiang Li; Mitsuhiro Shibayama
Soft Matter, 16, 48, 10946, 10953, Royal Society of Chemistry (RSC), Nov. 2020, [Peer-reviewed], [International Magazine]
Scientific journal,

The mechanical properties of temperature-responsive poly(oligo-ethylene glycol methyl ether methacrylate)-based gels were investigated using dynamic viscoelasticity measurements to find applications in tissue and biomedical engineering.

Swelling Behaviors of Hydrogels with Alternating Neutral/Highly Charged Sequences
Jian Tang; Takuya Katashima; Xiang Li; Yoshiro Mitsukami; Yuki Yokoyama; Naoyuki Sakumichi; Ung-il Chung; Mitsuhiro Shibayama; Takamasa Sakai
Macromolecules, 53, 19, 8244, 8254, American Chemical Society (ACS), 13 Oct. 2020, [Peer-reviewed], [International Magazine]
Scientific journal

Microphase-separated structures of ion gels consisting of ABA-type block copolymers and an ionic liquid: A key to escape from the trade-off between mechanical and transport properties
Haruna Mizuno; Kei Hashimoto; Ryota Tamate; Hisashi Kokubo; Kazuhide Ueno; Xiang Li; Masayoshi Watanabe
Polymer, 206, 122849, 122849, Oct. 2020, [Peer-reviewed], [International Magazine]
Scientific journal

Selective Doping of Positive and Negative Spatial Defects into Polymer Gels by Tuning the Pregel Packing Conditions of Star Polymers
Yui Tsuji; Shintaro Nakagawa; Caidric Indaya Gupit; Masashi Ohira; Mitsuhiro Shibayama; Xiang Li
Macromolecules, 53, 17, 7537, 7545, American Chemical Society (ACS), 08 Sep. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
Scientific journal

Controlled assembly of filamentous viruses into hierarchical nano- to microstructures at liquid/liquid interfaces
Michihiro Tanaka; Toshiki Sawada; Xiang Li; Takeshi Serizawa
RSC Advances, 10, 44, 26313, 26318, 14 Jul. 2020, [Peer-reviewed], [International Magazine]
Scientific journal

A Simple and Versatile Method for the Construction of Nearly Ideal Polymer Networks
Xin Huang; Shintaro Nakagawa; Xiang Li; Mitsuhiro Shibayama; Naoko Yoshie
Angewandte Chemie International Edition, 59, 24, 9646, 9652, 08 Jun. 2020, [Peer-reviewed], [International Magazine]
Scientific journal

Quantitative Structure Analysis of a Near-Ideal Polymer Network with Deuterium Label by Small-Angle Neutron Scattering
Masashi Ohira; Yui Tsuji; Nobuyuki Watanabe; Ken Morishima; Elliot P. Gilbert; Xiang Li; Mitsuhiro Shibayama
Macromolecules, 53, 10, 4047, 4054, 26 May 2020, [Peer-reviewed], [Corresponding author], ［Internationally co-authored］, [International Magazine]
Scientific journal

Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues
Etsuo A. Susaki; Chika Shimizu; Akihiro Kuno; Kazuki Tainaka; Xiang Li; Kengo Nishi; Ken Morishima; Hiroaki Ono; Koji L. Ode; Yuki Saeki; Kazunari Miyamichi; Kaoru Isa; Chihiro Yokoyama; Hiroki Kitaura; Masako Ikemura; Tetsuo Ushiku; Yoshihiro Shimizu; Takashi Saito; Takaomi C. Saido; Masashi Fukayama; Hirotaka Onoe; Kazushige Touhara; Tadashi Isa; Akiyoshi Kakita; Mitsuhiro Shibayama; Hiroki R. Ueda
Nature Communications, 11, 1, 27 Apr. 2020, [Peer-reviewed], [International Magazine]
Scientific journal

Nanostructures and Viscosities of Nafion Dispersions in Water/Ethanol from Dilute to Concentrated Regimes
Caidric Indaya Gupit; Xiang Li; Ryosuke Maekawa; Naoki Hasegawa; Hiroki Iwase; Shinichi Takata; Mitsuhiro Shibayama
Macromolecules, 53, 4, 1464, 1473, 25 Feb. 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
Scientific journal

Characterization of N-phenylmaleimide-terminated poly(ethylene glycol)s and their application to a tetra-arm poly(ethylene glycol) gel
Rikito Takashima; Masashi Ohira; Hirogi Yokochi; Daisuke Aoki; Xiang Li; Hideyuki Otsuka
Soft Matter, 16, 48, 10869, 10875, 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
Scientific journal

Polymer gel with a flexible and highly ordered three-dimensional network synthesized via bond percolation
Xiang Li; Sintaro Nakagawa; Yui Tsuji; Nobuyuki Watanabe; Mitsuhiro Shibayama
Science Advances, 5, 12, 06 Dec. 2019, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
Scientific journal

Transport and Mechanical Properties of ABA-type Triblock Copolymer Ion Gels Correlated with Their Microstructures
Kei Hashimoto; Manabu Hirasawa; Hisashi Kokubo; Ryota Tamate; Xiang Li; Mitsuhiro Shibayama; Masayoshi Watanabe
Macromolecules, 52, 21, 8430, 8439, 12 Nov. 2019, [Peer-reviewed], [International Magazine]
Scientific journal

Effect of ionic liquid structure on viscoelastic behavior of hydrogen-bonded micellar ion gels
Ryota Tamate; Kei Hashimoto; Xiang Li; Mitsuhiro Shibayama; Masayoshi Watanabe
Polymer, 178, 121694, 121694, Sep. 2019, [Peer-reviewed], [International Magazine]
Scientific journal

Dynamics of Critical Clusters Synthesized by End-Coupling of Four-Armed Poly(ethylene glycol)s
Xiang Li; Takako Noritomi; Takamasa Sakai; Elliot P. Gilbert; Mitsuhiro Shibayama
Macromolecules, 52, 14, 5086, 5094, 23 Jul. 2019, [Peer-reviewed], [Lead author, Corresponding author], ［Internationally co-authored］, [International Magazine]
Scientific journal

Diffusion Behavior of Water Molecules in Hydrogels with Controlled Network Structure
Takeshi Fujiyabu; Xiang Li; Ung-il Chung; Takamasa Sakai
Macromolecules, 52, 5, 1923, 1929, 12 Mar. 2019, [Peer-reviewed], [International Magazine]
Scientific journal

Viscoelastic change of block copolymer ion gels in a photo-switchable azobenzene ionic liquid triggered by light
Caihong Wang; Kei Hashimoto; Ryota Tamate; Hisashi Kokubo; Ken Morishima; Xiang Li; Mitsuhiro Shibayama; Fengniu Lu; Takashi Nakanishi; Masayoshi Watanabe
Chemical Communications, 55, 12, 1710, 1713, 11 Feb. 2019, [Peer-reviewed], [International Magazine]
Scientific journal

Formation of Clusters in Whiskies During the Maturation Process
Ken Morishima; Noriko Nakamura; Keisuke Matsui; Yoshikazu Tanaka; Hiroyasu Masunaga; Shoko Mori; Takashi Iwashita; Xiang Li; Mitsuhiro Shibayama
Journal of Food Science, 84, 1, 59, 64, Jan. 2019, [Peer-reviewed], [International Magazine]
Scientific journal

Precision polymer network science with tetra-PEG gels—a decade history and future
Mitsuhiro Shibayama; Xiang Li; Takamasa Sakai
Colloid and Polymer Science, 297, 1, 1, 12, Jan. 2019, [Peer-reviewed], [Invited], [International Magazine]
Scientific journal

Dynamic Fluctuations of Thermoresponsive Poly(oligo-ethylene glycol methyl ether methacrylate)-Based Hydrogels Investigated by Dynamic Light Scattering
Takuma Kureha; Kyohei Hayashi; Masashi Ohira; Xiang Li; Mitsuhiro Shibayama
Macromolecules, 51, 21, 8932, 8939, 13 Nov. 2018, [Peer-reviewed], [International Magazine]
Scientific journal

Small-angle scattering study of tetra-poly(acrylic acid) gels
Ken Morishima; Xiang Li; Kazuyuki Oshima; Yoshiro Mitsukami; Mitsuhiro Shibayama
The Journal of Chemical Physics, 149, 16, 163301, 163301, 28 Oct. 2018, [Peer-reviewed], [International Magazine]
Scientific journal

Dynamics of thermoresponsive conetwork gels composed of poly(ethylene glycol) and poly(ethyl glycidyl ether-co-methyl glycidyl ether)
Masashi Ohira; Xiang Li; Caidric Indaya Gupit; Hiroyuki Kamata; Takamasa Sakai; Mitsuhiro Shibayama
Polymer, 155, 75, 82, Oct. 2018, [Peer-reviewed], [Corresponding author], [International Magazine]
Scientific journal

Sulfonated Polyimide/Ionic Liquid Composite Membranes for CO2 Separation: Transport Properties in Relation to Their Nanostructures
Akika Ito; Tomohiro Yasuda; Tetsuro Yoshioka; Akihiro Yoshida; Xiang Li; Kei Hashimoto; Kazukiyo Nagai; Mitsuhiro Shibayama; Masayoshi Watanabe
Macromolecules, 51, 18, 7112, 7120, 25 Sep. 2018, [Peer-reviewed], [International Magazine]
Scientific journal

Insight into the Microscopic Structure of Module-Assembled Thermoresponsive Conetwork Hydrogels
Shintaro Nakagawa; Xiang Li; Mitsuhiro Shibayama; Hiroyuki Kamata; Takamasa Sakai; Elliot Paul Gilbert
Macromolecules, 51, 17, 6645, 6652, 11 Sep. 2018, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
Scientific journal

Self-Healing Micellar Ion Gels Based on Multiple Hydrogen Bonding
Ryota Tamate; Kei Hashimoto; Tatsuhiro Horii; Manabu Hirasawa; Xiang Li; Mitsuhiro Shibayama; Masayoshi Watanabe
Advanced Materials, 30, 36, 1802792, 1802792, Sep. 2018, [Peer-reviewed], [International Magazine]
Scientific journal

Three cooperative diffusion coefficients describing dynamics of polymer gels
Takeshi Fujiyabu; Felicia Toni; Xiang Li; Ung-il Chung; Takamasa Sakai
Chemical Communications, 54, 50, 6784, 6787, 25 Jun. 2018, [Peer-reviewed], [International Magazine]
Scientific journal

Evaluation of Mesh Size in Model Polymer Networks Consisting of Tetra-Arm and Linear Poly(ethylene glycol)s
Yui Tsuji; Xiang Li; Mitsuhiro Shibayama
Gels, 4, 2, 50, 50, 25 May 2018, [Peer-reviewed], [Corresponding author], [International Magazine]
Scientific journal

Gels: From Soft Matter to BioMatter
Mitsuhiro Shibayama; Xiang Li; Takamasa Sakai
Industrial & Engineering Chemistry Research, 57, 4, 1121, 1128, 31 Jan. 2018, [Peer-reviewed], [Invited], [International Magazine]
Scientific journal

Probe Diffusion Dynamic Light Scattering of Polymer solutions and Gels
Mitsuhiro Shibayama; Xiang Li
ACS Symposium Series, 51, 69, Jan. 2018, [Peer-reviewed], [International Magazine]
In book

Probe Diffusion during Sol-Gel Transition of a Radical Polymerization System Using Isorefractive Dynamic Light Scattering
Nobuyuki Watanabe; Xiang Li; Mitsuhiro Shibayama
Macromolecules, 50, 24, 9726, 9733, 26 Dec. 2017, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal

Permeation of Water through Hydrogels with Controlled Network Structure
Takeshi Fujiyabu; Xiang Li; Mitsuhiro Shibayama; Ung-il Chung; Takamasa Sakai
Macromolecules, 50, 23, 9411, 9416, 12 Dec. 2017, [Peer-reviewed], [International Magazine]
Scientific journal

SANS Study on Critical Polymer Clusters of Tetra-Functional Polymers
Xiang Li; Kazu Hirosawa; Takamasa Sakai; Elliot P. Gilbert; Mitsuhiro Shibayama
Macromolecules, 50, 9, 3655, 3661, 09 May 2017, [Peer-reviewed], [Lead author, Corresponding author], ［Internationally co-authored］, [International Magazine]
Scientific journal

Microscopic Structure of the “Nonswellable” Thermoresponsive Amphiphilic Conetwork
Shintaro Nakagawa; Xiang Li; Hiroyuki Kamata; Takamasa Sakai; Elliot Paul Gilbert; Mitsuhiro Shibayama
Macromolecules, 50, 8, 3388, 3395, 25 Apr. 2017, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
Scientific journal

Probe Diffusion of Sol–Gel Transition in an Isorefractive Polymer Solution
Xiang Li; Nobuyuki Watanabe; Takamasa Sakai; Mitsuhiro Shibayama
Macromolecules, 50, 7, 2916, 2922, 11 Apr. 2017, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
Scientific journal

Fast-forming hydrogel with ultralow polymeric content as an artificial vitreous body
Kaori Hayashi; Fumiki Okamoto; Sujin Hoshi; Takuya Katashima; Denise C. Zujur; Xiang Li; Mitsuhiro Shibayama; Elliot P. Gilbert; Ung-il Chung; Shinsuke Ohba; Tetsuro Oshika; Takamasa Sakai
NATURE BIOMEDICAL ENGINEERING, 1, 3, Mar. 2017, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Scientific journal

Design of Hydrogels for Biomedical Applications
Hiroyuki Kamata; Xiang Li; Ung-il Chung; Takamasa Sakai
Advanced Healthcare Materials, 4, 16, 2360, 2374, Nov. 2015, [Peer-reviewed], [International Magazine]
Scientific journal

Electrophoretic mobility of semi-flexible double-stranded DNA in defect-controlled polymer networks: Mechanism investigation and role of structural parameters
Kateryna Khairulina; Xiang Li; Kengo Nishi; Mitsuhiro Shibayama; Ung-il Chung; Takamasa Sakai
The Journal of Chemical Physics, 142, 23, 234904, 234904, 21 Jun. 2015, [Peer-reviewed], [International Magazine]
Scientific journal

Degradation Behavior of Polymer Gels Caused by Nonspecific Cleavages of Network Strands
Xiang Li; Shinji Kondo; Ung-il Chung; Takamasa Sakai
Chemistry of Materials, 26, 18, 5352, 5357, 23 Sep. 2014, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

Electrophoretic Mobility of Double-Stranded DNA in Polymer Solutions and Gels with Tuned Structures
Xiang Li; Kateryna Khairulina; Ung-il Chung; Takamasa Sakai
Macromolecules, 47, 11, 3582, 3586, 10 Jun. 2014, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

Migration Behavior of Rodlike dsDNA under Electric Field in Homogeneous Polymer Networks
Xiang Li; Kateryna Khairulina; Ung-il Chung; Takamasa Sakai
Macromolecules, 46, 21, 8657, 8663, 12 Nov. 2013, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

Precise Control and Prediction of Hydrogel Degradation Behavior
Xiang Li; Yusuke Tsutsui; Takuro Matsunaga; Mitsuhiro Shibayama; Ung-il Chung; Takamasa Sakai
Macromolecules, 44, 9, 3567, 3571, 10 May 2011, [Peer-reviewed], [Lead author], [International Magazine]
Scientific journal

ゲル臨界濃度付近で作成した高分子ゲルの疎水化を伴う相分離現象
石川 昇平; 岩永 康秀; 畝山 多加志; Li Xiang; 北條 宏徳; 藤長 郁夫; 片島 拓弥; 齋藤 琢; 岡田 康志; 鄭 雄一; 作道 直幸; 酒井 崇匡, 日本バイオマテリアル学会大会予稿集, 44回, 189, 189, Nov. 2022
日本バイオマテリアル学会, Japanese

ハイドロゲルの表面粘着性に影響する因子
高穎; 秋元文; 田中信行; Li Xiang; 柴山充弘; 太田裕治; 小野田実真; 春園嘉英; 田中 陽; 吉田亮, 高分子学会予稿集, May 2020

水素結合を利用した自己修復性ミセル型イオンゲルの創製と高分子ゲル電解質への応用
玉手亮多; 橋本慧; 堀井辰衛; LI Xiang; 柴山充弘; 渡邉正義, 高分子ゲル研究討論会講演要旨集, 30th, 87‐88, 09 Jan. 2019
Japanese

水素結合を利用した自己修復性ミセル型イオンゲルの創製と高分子ゲル電解質への応用
玉手亮多; 橋本慧; 堀井辰衛; LI Xiang; 柴山充弘; 渡邉正義, 高分子学会予稿集(CD-ROM), 67, 2, ROMBUNNO.2S15, 29 Aug. 2018
Japanese

Amphiphilic Polymer Co-networks: Synthesis, Properties, Modelling and Applications
Costas S Patrickios; Takamasa Sakai; Xiang Li, Chapter 6. Structure and Physical Properties of Amphiphilic Polymer Co-network Hydrogels with Controlled Structures
Royal Society of Chemistry, Apr. 2020, 9781839161346, English, ［Internationally co-authored］, [Joint work]

Physics of Polymer Gels
Takamasa Sakai; Xiang Li, Chapter 6 Mass Transport in Polymer Gels, Chapter 9 Structural Analysis by Light and Neutron Scattering
Wiley, Feb. 2020, 9783527346554, English, Scholarly book, [Joint work]

基礎高分子科学
高分子学会, 8.5 ゲルの輸送現象
東京化学同人, Jan. 2020, 9784807909629, xvi, 478p, Japanese, [Joint work]

刺激応答性高分子ハンドブック
宮田, 隆志, 第3章4節 制御された網目構造を有する温度応答性ハイドロゲル
エヌ・ティー・エス, Dec. 2018, 9784860435356, xxiv, 806p, 図版 [30] p, Japanese, [Joint work]

高分子ゲルの物理学 : 構造・物性からその応用まで
酒井, 崇匡; 片島, 拓弥; 赤木, 友紀; Xiang, Li
東京大学出版会, 2017, 9784130628433, vii, 198p, Japanese, [Joint work]

Theoretical and experimental analysis of the physical gel degradation
Xiang Li
International Symposium on Polymer Physics, 15 Jul. 2026, Oral presentation
13 Jul. 2026 - 16 Jul. 2026

DNA架橋ゲルの精密分子設計と材料力学特性の制御
Li Xiang
日本化学会 春季年会, 28 Mar. 2025, Invited oral presentation
大阪府吹田市関西大学千里山キャンパス, Japan, [Invited], [Domestic Conference]

Star-polymer-DNA gels showing predictable stress relaxation behavior
Xiang Li
47th Annual Meeting of the Molecular Biology Scociety of Japan, 29 Nov. 2024, English, Invited oral presentation
27 Nov. 2024 - 29 Nov. 2024, Fukuoka, Japan, [Invited], [Domestic Conference]

Stretch-induced Highly Ordered Structures in Gels
Xiang Li
Gel Symposium 2024, 21 Nov. 2024, English, Invited oral presentation
17 Nov. 2024 - 21 Nov. 2024, Okinawa, Japan, [Invited], [International presentation]

ソフトマターのミクロ構造
Li Xiang
北海道高分子若手研究会, 26 Aug. 2023, Invited oral presentation
北海道札幌市定山渓ホテル鹿の湯, Japan, [Invited], [Domestic Conference]

Star-polymer-DNA gels showing predictable stress relaxation behavior
Xiang Li
8th Pacific Rim Conference on Rheology, 18 May 2023, Oral presentation
15 May 2023 - 19 May 2023, Vancouver, Canada, [International presentation]

柔らかい材料のナノ構造
Li Xiang
青森地区 高分子学会東北支部講演会, 20 Sep. 2022, 高分子学会東北支部, Invited oral presentation
青森県弘前市弘前大学, [Invited], [Domestic Conference]

Bond percolationによるゲルの時空間構造制御
Li Xiang
高分子討論会, 05 Sep. 2022, 高分子学会, Invited oral presentation
北海道札幌市北海道大学, [Invited], [Domestic Conference]

Nanostructures of polymer gels – towards highly homogeneous gels, International webinar on gels and networks
Xiang Li
International webinar on gels and networks, 15 Feb. 2021, International webinar on gels and networks, Invited oral presentation
Online webinar, [Invited], [International presentation]

Polymer gel with a flexible and highly ordered three-dimensional network synthesized via bond-percolation
Xiang Li
2nd GLowing Polymer Symposium in KANTO, 30 Nov. 2019, 高分子学会関東支部, Invited oral presentation
東京都葛飾区 東京理科大学 葛飾キャンパス, [Invited], [Domestic Conference]

散乱から見たゾル・ゲル転移
Li Xiang
関東高分子若手研究会サマーキャンプ, 01 Aug. 2018, 高分子学会関東高分子若手研究会, Invited oral presentation
千葉県館山市アカデミーハウス館山, [Invited]

The boundary of sol and gel seen by light
Xiang Li
東京大学―清華大学学術シンポジウム2018, 20 Jul. 2018, 東京大学, Invited oral presentation
東京都文京区東京大学本郷キャンパス, [Invited], [International presentation]

プローブ粒子から見たゲル化過程
Li Xiang
高分子学会東海支部 高分子講演会, 20 Dec. 2016, 高分子学会東海支部, Invited oral presentation
静岡県浜松市アクトシティ浜松, [Invited], [Domestic Conference]

均一高分子網目構造内におけるDNAの電気泳動挙動
Li Xiang
機能物性融合科学研究会, 02 Apr. 2015, 東京大学物性研究所, Invited oral presentation
千葉県柏市東京大学柏の葉キャンパス, [Invited], [Domestic Conference]

ソフトマター科学概論, 2024年, 修士課程, 生命科学院

生命融合科学概論, 2024年, 修士課程, 生命科学院

ソフトマター解析学特論, 2024年, 修士課程, 生命科学院

生物系の分光学, 2024年, 学士課程, 理学部

英語演習, 2024年, 学士課程, 全学教育

酒井複素ゲルプロジェクト
戦略的な研究開発の推進 戦略的創造研究推進事業 ERATO
Oct. 2024 - Mar. 2030
酒井 崇匡; 北條 宏徳; Li Xiang; 作道 直幸; 池田昌司; 中野健
高分子ゲルは、高分子網目が溶媒を含んだ物質の総称であり、様々な食品に含まれるほか、ソフトコンタクトレンズやオムツなどに活用されるなど多岐にわたって身近に存在しています。また、高分子ゲルは、弾性率として6桁以上の幅広い範囲をカバーする粘弾性物質群です。一方、高分子ゲルはその複雑で不均一な網目構造により、構造および物性の自在な制御は困難でした。研究総括らが開発したテトラゲルは、ミクロな網目構造を精密制御することによりマクロ物性を精密かつ連続的に制御可能な、極めて均一な構造を有する高分子ゲル群です。
本研究領域では、テトラゲルで得られた学理をもとに、新しい理論体系の構築や網目構造の精密な観察等を行うことにより、一般の高分子ゲルの包括的理解(ゲル科学の探求)に挑戦します。また、生体とゲルの相互作用の制御が可能な生体組織再生の足場材料の開発(ゲル・生体相互作用の解明)を進めます。
さらに、実体を伴う高分子ゲル(具象ゲル)の理解をもとに、普遍的な要素をとりだして抽象化したゲル(抽象ゲル)という概念を提唱し、具象ゲルおよび抽象ゲルを含む新しいゲルとして「複素ゲル」という新たな領域の構築を目指します。
科学技術振興機構, 東京大学, Coinvestigator

Design of Low Entropy Polymer Network Materials for Unique Functions
Grants-in-Aid for Scientific Research
20 Dec. 2022 - 31 Mar. 2029
グン 剣萍; Li Xiang; 野々山 貴行; 中島 祐
Japan Society for the Promotion of Science, Fund for the Promotion of Joint International Research (International Leading Research ), Hokkaido University, Coinvestigator, 22K21342

量子散乱による超高均一ゲル形成の学理解明とその展開
戦略的な研究開発の推進 創発的研究支援事業
Apr. 2022 - Mar. 2028
Li Xiang
JST, 北海道大学, JPMJFR201Z

Bond percolationゲルによる網目構造と力学物性の相関解明
科学研究費助成事業
Apr. 2022 - Mar. 2027
Li Xiang
日本学術振興会, 基盤研究(B), 北海道大学, 22H02135

バイオ・高分子ビッグデータ駆動による 完全循環型バイオアダプティブ材料の創出
データ創出・活用型マテリアル研究開発プロジェクト
Sep. 2022 - Mar. 2026
文部科学省, Coinvestigator, JPMXP1122714694

Fundamental understanding of polymer gels and sponges
Grants-in-Aid for Scientific Research
05 Apr. 2021 - 31 Mar. 2025
酒井 崇匡; 片島 拓弥; Li Xiang; 作道 直幸
ゲルやスポンジなどの含水性高分子網目材料は、生体組織と類似の構造・物性を有し、材料科学的にも生体材料応用を目指す上でも興味深い材料である。その一方で、両者には、網目サイズや内包する水との相溶性など、相違点も多く存在する。
本研究では、「ゲルとスポンジの類似性と特異性」を明らかにし、ゲルとスポンジを繋ぐ横断的な学理を確立することを目的とする。申請者が世界で初めて確立した、同一の成分組成からゲルとスポンジを作り分ける手法を用い、ゲル、スポンジ、ゲル・スポンジ中間物質を系統的に作製し、構造・物性を網羅的に測定・解析することで分野横断的な体系化を試みる。
初年度は、ゲルとスポンジが作り分けられる条件を明らかにするために、高分子の濃度と特定の塩濃度をパラメータとして相図の作製を行った。ゲル化・スポンジ化過程の構造形成の速度論を共焦点顕微鏡および小角X線散乱を用いて、評価した。さらに低濃度領域におけるスポンジ化は、ゲル化反応に伴う濃度ゆらぎの増大、およびパーコレーションに伴う弾性発現をきっかけに相分離が起こることが明らかになった。この結果は、ゲル化より長い時間スケールで、希薄・濃厚なゲル相に分離する極めて特異的な現象であることを実験的に明らかにした。さらに粗視化シミュレーションモデルを用いることで、散乱実験の結果をメゾスケール構造単位で再現でき、分子論的な描像を明らかにした。
また、in vivo実験では生理活性モチーフを必要とせずに、生体内で脂肪の成長を誘導することが観察され、スポンジ構造を有するゲルの再生足場バイオマテリアルへの応用の礎となる結果を得た。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), The University of Tokyo, 21H04688

皮膚に対する接着/脱離スイッチングを実現するスマートハイドロゲル表面の開発
A-STEP
Dec. 2020 - Mar. 2023
秋元 文; 田中 信行; 太田 裕治; Li Xiang
JST, The University of Tokyo, Coinvestigator

Investigation of gel's mechanical properties and their spatial inhomogeneity
Grants-in-Aid for Scientific Research
01 Apr. 2019 - 31 Mar. 2022
Li Xiang
Based on a gel with extremely low spatial inhomogeneity that has been successfully synthesized in recent years, we intentionally introduced spatial inhomogeneity without changing the basic unit, cross-linking agent, etc. We evaluated the effect of spatial defects on the mechanical properties of the gel. Small-angle X-ray scattering experiments revealed that the structural defects were successfully introduced as intended. The type, size, and volume fraction of the defects in the gel were also determined in detail. Furthermore, a method of small-angle X-ray scattering while elongating the gel has been established, which enables a more quantitative analysis of the scattering pattern, which was previously unclear.
Japan Society for the Promotion of Science, Grant-in-Aid for Early-Career Scientists, 東京大学, 19K15628

超高均一ゲル作製技術の汎用高分子種への適応
東京大学GAPファンド
Apr. 2020 - Mar. 2021
Li Xiang
東京大学, 東京大学, Principal investigator

Developments and Potential Applications of Ideal Polyelectrolyte Gels
Grants-in-Aid for Scientific Research
01 Apr. 2016 - 31 Mar. 2020
Shibayama Mitsuhiro
By synthesizing the ideal chargeable polymer and network structure, various complicated physical phenomena hidden in the charged polymer were clarified. For example, by synthesizing an ideal network of charged polymers, we discovered that the characteristic distance of the polyelectrolytes is a unique distance that does not depend on the distance between cross-linking points. In addition, by making the mouse brain transparent and examining its structure in detail using small-angle X-ray scattering, we discovered the characteristic correlation distance of the electrolyte described above, indicating the brain is a sort of polyelectrolyte gel. Furthermore, we have established a gelling method that does not have any spatial inhomogeneity by closely packing the star-shaped polymers. This achieved important requirements that lead to an understanding of the structure and physical properties of the electrolyte gel.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), The University of Tokyo, 16H02277

Fabrication of homogeneous polymer gels by using precise and reversible physical crosslinkers
Grants-in-Aid for Scientific Research
01 Apr. 2017 - 31 Mar. 2019
Li Xiang
By mixing two kinds of four-armed PEG DNA conjugates in aqueous solution at room temperature, the solution immediately changed to a solid gel. This polymer gel shows repetitive sol-gel transition by elevating and lowering the sample temperature. By using the small angle neutron scattering, we investigated the spatial homogeneity of this polymer gel. The scattering patterns of gel was exactly the same with the uncrosslinked sol, indicating that the network of this polymer gel is highly homogeneous. By measuring the dynamic viscoelastic property of this gel, we found that this polymer gel shows very sharp stimuli-response against the temperature change.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), The University of Tokyo, 17K14536

柔らかい物質のナノ構造 「散乱法を用いたソフトマターの構造解析」
29 Jun. 2024 - 29 Jun. 2024
Lecturer
北海道大学, 北海道新聞社
北大道新アカデミー

DNA POLYMERS WILL GIVE SOFT ROBOTS GOOD GENES
04 Mar. 2022
Other than myself
SYFY WIRE
SYFY WIRE
[Internet]

ハイドロゲル DNAで流動性制御 北大など ソフトロボに応用期待
21 Feb. 2022
Other than myself
日刊工業新聞
24面, [Paper]

DNA Strands Used To Create Tuneable, Elastic and Temperature-Sensitive Gel
17 Feb. 2022
Other than myself
Technology Networks
Technology Networks
[Internet]

Simulations Lead to the Fabrication of Polymer-DNA Gel with On-Demand Viscoelastic Properties
17 Feb. 2022
Other than myself
AZO Materials
[Internet]

DNA design brings predictability to polymer gels
16 Feb. 2022
Other than myself
AAAS
EurekAlert!
[Internet]

TBS「未来の起源」
26 Jan. 2020
TBS
未来の起源
[Media report]

東大ら，超高均一で透明なゲルを創出
10 Dec. 2019
OPTRONICS ONLINE
https://optronics-media.com/news/20191210/61730/, [Internet]

均一構造で透明なゲル、東大が簡単な作製方法開発
10 Dec. 2019
日刊工業新聞
総合3, [Paper]