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Domae Mana
| Research Institute for Electronic Science Research Center of Mathematics for Social Creativity | Research Fellow |
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■ URLresearchmap URLホームページURL■ Various IDs
Researcher number
- 10994832
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Research activity information
■ Papers- Neurological confirmation of periplanone-D exploitation as a primary sex pheromone and counteractions of other components in the smoky brown cockroach Periplaneta fuliginosa.
Mana Domae; Masazumi Iwasaki; Hiroshi Nishino
Cell and tissue research, 10 Jan. 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, The smoky brown cockroach, Periplaneta fuliginosa, is a peridomestic pest inhabiting broad regions of the world from temperate to subtropical zones. In common with other related species such as the American cockroach, Periplaneta americana, female-emitted sex pheromone components, named periplanones, are known to be key volatiles that elicit long-range attraction and courtship rituals in males. How periplanones are processed in the nervous system has been entirely unexplored in P. fuliginosa. By using pheromone compounds, periplanones A, B, C, and D, as stimulants to the antenna, we identified four distinct types of interneurons (projection neurons) that relay pheromonal signals from a single olfactory glomerulus of the first-order olfactory center (antennal lobe) to higher-order centers in the ipsilateral hemibrain. All glomeruli innervated by pheromone-responsive projection neurons clustered near the antennal nerve entrance of the antennal lobe. The projection neuron with dendrites in the largest glomerulus was tuned specifically to periplanone-D, and adding other components to periplanone-D counteracted the excitation elicited by periplanone-D alone. Likewise, the projection neuron with dendrites in the second largest glomerulus and that with dendrites in a medium-sized glomerulus were tuned to periplanone-A and periplanone-B, respectively. Our results are, therefore, consistent with behavioral findings that periplanone-D alone acts as a primary sex attractant and that other components act as potential behavioral antagonists. Moreover, a comparison of the glomeruli in P. fuliginosa and P. americana suggested that there are differences in the sizes of homologous glomeruli, as well as in the ligands they process. - Interactive parallel sex pheromone circuits that promote and suppress courtship behaviors in the cockroach
Kosuke Tateishi; Takayuki Watanabe; Mana Domae; Atsushi Ugajin; Hiroshi Nishino; Hiroyuki Nakagawa; Makoto Mizunami; Hidehiro Watanabe
PNAS Nexus, Oxford University Press (OUP), 15 Apr. 2024, [Peer-reviewed]
Scientific journal, Abstract
Many animals use multi-component sex pheromones for mating, but the specific function and neural processing of each pheromone component remain unclear. The cockroach Periplaneta americana is a model for studying sex pheromone communication, and an adult female emits major and minor sex pheromone components, periplanone-B and -A (PB and PA), respectively. Attraction and courtship behaviors (wing-raising and abdominal extension) are strongly expressed when adult males are exposed to PB but weakly expressed when they are exposed to PA. When major PB is presented together with minor PA, behaviors elicited by PB were impaired, indicating that PA can both promote and suppress courtship behaviors depending on the pheromonal context. In this study, we identified the receptor genes for PA and PB and investigated the effects of knocking down each receptor gene on the activities of PA- and PB-responsive sensory neurons (PA- and PB-SNs), and their postsynaptic interneurons, and as well as effects on courtship behaviors in males. We found that PB strongly and PA weakly activate PB-SNs and their postsynaptic neurons, and activation of the PB-processing pathway is critical for the expression of courtship behaviors. PA also activates PA-SNs and the PA-processing pathway. When PA and PB are simultaneously presented, the PB-processing pathway undergoes inhibitory control by the PA-processing pathway, which weakens the expression of courtship behaviors. Our data indicates that physiological interactions between the PA- and PB-processing pathways positively and negatively mediate the attraction and courtship behaviors elicited by sex pheromones. - Management of Nuisance Macromoths in Expressways through Academic-Industrial Collaboration: Light Trap Designed on the Basis of Moths' Preferences for Light Attributes
Keigo Kurihara; Toshiaki Ito; Yukihisa Sato; Takanori Uesugi; Satoru Yamauchi; Masahiro Komatsu; Susumu Saito; Mana Domae; Hiroshi Nishino
Zoological Science, 39, 4, Zoological Society of Japan, 02 May 2022, [Peer-reviewed]
Scientific journal - Management of flying insects on expressways through an academic-industrial collaboration: evaluation of the effect of light wavelengths and meteorological factors on insect attraction
Masahiro Komatsu; Keigo Kurihara; Susumu Saito; Mana Domae; Naoki Masuya; Yuta Shimura; Shunichiro Kajiyama; Yuna Kanda; Kouki Sugizaki; Kouji Ebina; Osamu Ikeda; Yudai Moriwaki; Naohiro Atsumi; Katsuyoshi Abe; Tadashi Maruyama; Satoshi Watanabe; Hiroshi Nishino
Zoological Letters, 6, 1, Springer Science and Business Media LLC, 26 Nov. 2020, [Peer-reviewed]
Scientific journal, Abstract
Insect outbreaks often occur in the absence of natural enemies and in the presence of excess suitable host materials. Outbreaks of gypsy moths are especially problematic in remote areas located in high-latitude regions in Japan because the majority of adults emerge during the short summer season and initiate synchronous mass flight toward artificial lights. The aggregation of moths in public facilities not only is an annoyance to visitors but also permits the establishment of new populations the following year. The aim of this study was to establish a method to reduce the numbers of large moths that are attracted to lights in the rest areas of expressways in Hokkaido based on the results of research on their behavioral ecology and physiology. First, we conducted extensive insect surveys using light traps that emit light at different wavelengths; the traps were set along the expressways in the summers of 2014–2018. The insects attracted to the light were roughly classified into those showing a preference for broadband light wavelengths (from UV-A to green) and short light wavelengths (from UV-A to blue). The former included aquatic insects and winged ants, and the latter included moths and beetles. Next, we analyzed correlations between moth emergence and daily meteorological data. When gypsy moths were abundant during an outbreak, the daily catch of gypsy moths was positively correlated with the highest ambient temperature on the catch day but not with the visibility range, wind speed, or moon phase. In contrast, the daily catch of oak silkmoths did not correlate with any of these parameters. Our results provide guidance for the management of forest insects inhabiting cool-temperate to subarctic regions based on light wavelengths with reference to weather variables. - Separate But Interactive Parallel Olfactory Processing Streams Governed by Different Types of GABAergic Feedback Neurons in the Mushroom Body of a Basal Insect
Naomi Takahashi; Hiroshi Nishino; Mana Domae; Makoto Mizunami
The Journal of Neuroscience, 39, 44, 8690, 8704, Society for Neuroscience, 23 Sep. 2019, [Peer-reviewed]
Scientific journal, The basic organization of the olfactory system has been the subject of extensive studies in vertebrates and invertebrates. In many animals, GABA-ergic neurons inhibit spike activities of higher-order olfactory neurons and help sparsening of their odor representations. In the cockroach, two different types of GABA-immunoreactive interneurons (calyceal giants [CGs]) mainly project to the base and lip regions of the calyces (input areas) of the mushroom body (MB), a second-order olfactory center. The base and lip regions receive axon terminals of two different types of projection neurons, which receive synapses from different classes of olfactory sensory neurons (OSNs), and receive dendrites of different classes of Kenyon cells, MB intrinsic neurons. We performed intracellular recordings from pairs of CGs and MB output neurons (MBONs) of male American cockroaches, the latter receiving synapses from Kenyon cells, and we found that a CG receives excitatory synapses from an MBON and that odor responses of the MBON are changed by current injection into the CG. Such feedback effects, however, were often weak or absent in pairs of neurons that belong to different streams, suggesting parallel organization of the recurrent pathways, although interactions between different streams were also evident. Cross-covariance analysis of the spike activities of CGs and MBONs suggested that odor stimulation produces synchronized spike activities in MBONs and then in CGs. We suggest that there are separate but interactive parallel streams to process odors detected by different OSNs throughout the olfactory processing system in cockroaches.
SIGNIFICANCE STATEMENTOrganizational principles of the olfactory system have been the subject of extensive studies. In cockroaches, signals from olfactory sensory neurons (OSNs) in two different classes of sensilla are sent to two different classes of projection neurons, which terminate in different areas of the mushroom body (MB), each area having dendrites of different classes of MB intrinsic neurons (Kenyon cells) and terminations of different classes of GABAergic neurons. Physiological and morphological assessments derived from simultaneous intracellular recordings/stainings from GABAergic neurons and MB output neurons suggested that GABAergic neurons play feedback roles and that odors detected by OSNs are processed in separate but interactive processing streams throughout the central olfactory system. - Functional unification of sex pheromone-receptive glomeruli in the invasive Turkestan cockroach derived from the genus Periplaneta
Mana Domae; Masazumi Iwasaki; Makoto Mizunami; Hiroshi Nishino
Neuroscience Letters, 708, 134320, 134320, Elsevier BV, Aug. 2019, [Peer-reviewed], [Lead author]
Scientific journal - Cricket tympanal organ revisited: morphology, development and possible functions of the adult-specific chitin core beneath the anterior tympanal membrane
Hiroshi Nishino; Mana Domae; Takuma Takanashi; Takaharu Okajima
Cell and Tissue Research, 377, 2, 193, 214, Springer Science and Business Media LLC, 04 Mar. 2019, [Peer-reviewed]
Scientific journal - Two types of sensory proliferation patterns underlie the formation of spatially tuned olfactory receptive fields in the cockroach Periplaneta americana
Hidehiro Watanabe; Yukino Koike; Kosuke Tateishi; Mana Domae; Hiroshi Nishino; Fumio Yokohari
Journal of Comparative Neurology, 526, 16, 2683, 2705, Wiley, 18 Oct. 2018, [Peer-reviewed]
Scientific journal, Abstract
In the cockroach Periplaneta americana, to represent pheromone source in the receptive space, axon terminals of sex pheromone‐receptive olfactory sensory neurons (pSNs) are topographically organized within the primary center, the macroglomerulus, according to the peripheral locations of sex pheromone‐receptive single walled (sw)‐B sensilla. In this study, we sought to determine when and where pSNs emerge in the nymphal antenna. We revealed two different pSN proliferation patterns that underlie the formation of topographic organization in the macroglomerulus. In nymphal antennae, which lack sw‐B sensilla, pSNs are identified in the shorter sensilla, termed sw‐A sensilla. Because new sw‐A sensilla emerge on the proximal antenna at every molt, topographic organization in the macroglomerulus must be formed by adding axon terminals of newly emerged pSNs to the lateral region in the macroglomerulus at each molt. At the final molt, a huge number of new sw‐B sensilla appeared throughout the whole antenna. Sw‐B sensilla in the proximal part of the adult antenna were newly formed during the last instar stage, whereas those located in the distal antenna were transformed from sw‐A sensilla. This transformation was accompanied by an increase in the number of pSNs. Axon terminals of newborn pSNs in new sw‐B sensilla were recruited to the lateral part of the macroglomerulus, whereas those of newborn pSNs in transformed sw‐B sensilla were recruited to the macroglomerulus according to the sensillar location. These mechanisms enable an increase in sensitivity to sex pheromone in adulthood while retaining the topographic map formed during the postembryonic development.
- 昆虫の光源定位の原理に根ざした誘引（非誘引）光源の開発
西野浩史; 堂前愛; 川田一力; 吉田和貴; 長進
大学見本市2024～イノベーション・ジャパン, 23 Aug. 2024, Japanese, Nominated symposium
22 Aug. 2024 - 23 Aug. 2024, [Invited] - Identification of sex pheromone responsive glomeruli and interneurons in the cockroach Periplaneta fuliginosa
M. Domae; K. Katoh; H. Nishino
日本比較生理生化学会 第45回大阪大会 (JSCPB2023)
02 Dec. 2023 - 03 Dec. 2023 - Functional elucidation of two sex pheromones in the American cockroach; from receptions to behaviors
K. Tateishi; T. Watanabe; M. Domae; H. Nishino; M. Mizunami; H. Watanabe
International Conference for Blattodea Research (ICBR 2023)
Apr. 2023 - Two distinct sex pheromone processing pathways in the American cockroach, from receptions to behaviors
K. Tateishi; T. Watanabe; M. Domae; H. Nishino; M. Mizunami; H. Watanabe
日本比較生理生化学会 第44回高知大会 (JSCPB2022)
Nov. 2022 - Comparative study of cricket auditory organs highlights modification of ossicles-like structures and tympanal membranes
H. Nishino; M. Domae; Y. Matsumoto; T. Takanashi
日本比較生理生化学会 第43回札幌オンライン大会(JSCPB2021)
04 Dec. 2021 - 05 Dec. 2021 - Postembryonic development of projection neurons in the cockroach antennal lobe.
H. Watanabe; Y. Otsuka; M. Domae; H. Ai; H. Nishino
日本比較生理生化学会 第41回東京大会(JSCPB2019)
30 Nov. 2019 - 01 Dec. 2019 - Flying insect management in summer highways through academic-industrial collaboration.
K. Kurihara; T. Ito; Y. Sato; M. Domae; M. Komatsu; N. Masuya; H. Nishino
日本比較生理生化学会 第41回東京大会(JSCPB2019)
30 Nov. 2019 - 01 Dec. 2019 - Sex pheromone processing in Turkestan cockroach
H. Nishino; M. Domae
日本比較生理生化学会 第40回神戸大会(JSCPB2018)
23 Nov. 2018 - 25 Nov. 2018 - Axonal layer-dependent dendritic organization of Kenyon cells in a hemimetabolous insect
H. Nishino; K. Katoh; M. Domae
日本比較生理生化学会 第39回福岡大会(JSCPB2017)
25 Nov. 2017 - 26 Nov. 2017
