SEARCH
Search Details
Umamichi Kana
| Faculty of Health Sciences | Assistant Professor |
Researcher basic information
■ URLresearchmap URLホームページURL■ Various IDs
Researcher number
- 51054803
Research KeywordResearch Field
Research activity information
■ Papers- Voluntary wheel running improves cognitive deficits and abnormal agonistic behavior induced by social isolation stress in mice
Kana Umamichi; Tomonori Furukawa; Chihiro Sato; Hiroyuki Miura; Kai Hatakenaka; Tomohito Nunomura; Misaki Mikami; Shuhei Koeda; Junko Yamada
Physiology & Behavior, Feb. 2026, [Peer-reviewed], [Lead author]
English, Scientific journal - Voluntary Exercise Improves Radiation-induced Brain Injury in Mice.
Hiroyuki Miura; Tomonori Furukawa; Chihiro Sato; Ayaka Monden; Tomohito Nunomura; Kana Umamichi; Kai Hatakenaka; Rina Yamazaki; Masaru Yamaguchi; Shuhei Koeda; Junko Yamada
Radiation research, 204, 5, 477, 488, 01 Nov. 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, Radiation-induced brain injury (RBI) adversely affects the quality of life and prognosis of patients with brain tumors who undergo radiation therapy. Although rehabilitation strategies are recommended for mitigating RBI, the underlying mechanisms remain poorly understood. Here, we focused on RBI after fractionated whole-brain irradiation (WBI) in adult mice and examined the effects of voluntary exercise (VE) on cognitive function, growth factors, neurogenesis, and synaptic plasticity. Male C57BL/6J mice, aged 10-12 weeks, were divided into four groups: cham control (Ctl), WBI, Ctl + VE, and WBI + VE. The WBI total dose was 8 Gy (4 Gy × 2 fractions). Voluntary exercise was provided for three weeks using a voluntary running wheel that was accessible 24 h a day. The effects of RBI and VE were analyzed using behavioral, biochemical, immunohistological, and electrophysiological evaluations. WBI significantly impaired cognitive functions including spatial working memory, reference memory, and cognitive flexibility. Additionally, WBI led to reduced plasma mature brain-derived neurotrophic factor (mBDNF) levels, neurogenic differentiation 1 (NeuroD1)-positive cell density in the dentate gyrus, and long-term potentiation in the hippocampal cornu ammonis 1 region. Conversely, VE intervention ameliorated these cognitive deficits and increased mBDNF levels, enhanced NeuroD1-positive cell density, and strengthened long-term potentiation. Our findings suggest that VE intervention mitigates the effects of RBI in adult mice by promoting neurogenesis and enhancing synaptic plasticity via growth factor upregulation. These results underscore the importance of physical activity in rehabilitation and suggest that VE is a noninvasive strategy for improving cognitive function in patients affected by RBI. - Effects of voluntary and forced exercise on brain health in adult rats
Chihiro Sato; Mitsuru Chiba; Tomonori Furukawa; Shuhei Koeda; Misaki Mikami; Kai Hatakenaka; Tomohito Nunomura; Kana Umamichi; Hiroyuki Miura; Junko Yamada
Journal of Brain Science, 52, Dec. 2024, [Peer-reviewed]
- 脳出血モデルマウスに対する異なる運動強度・運動様式の運動がストレスと血漿中BDNF産生に及ぼす影響
布村 倫仁; 佐藤 ちひろ; 古川 智範; 畑中 魁; 馬道 夏奈; 三浦 裕幸; 山崎 璃奈; 小枝 周平; 山田 順子, 基礎理学療法学, 28, Supplement, S19-1, S19-1, 2025
一般社団法人 日本基礎理学療法学会, Japanese - 洗濯動作の獲得によるリハビリ意欲の向上をきっかけに家事動作全般の獲得につながった事例 : MTDLPによるアセスメントを用いた関わりの明確化の重要性
馬道 夏奈; 今井 寛人; 小枝 周平; 佐藤 ちひろ; 算用子 暁美, 青森県作業療法研究 = Bulletin of Aomori occupational therapy / 青森県作業療法士会 編, 32, 1, 41, 44, Feb. 2024, [Peer-reviewed], [Lead author]
弘前 : 青森県作業療法士会, Japanese - 脳出血モデルマウスに対する自発的および強制的走行に伴うストレスが機能回復に及ぼす影響
布村 倫仁; 佐藤 ちひろ; 小枝 周平; 畑中 魁; 馬道 夏奈; 三浦 裕幸; 山本 賢雅; 佐々木 都子; 岩田 学; 山田 順子, 基礎理学療法学, 26, Supplement, S43-2, S43-2, 2023
一般社団法人 日本基礎理学療法学会, Japanese
- The Importance of Sharing Goals with Patients and Occupational Therapists -A case of subacute stroke patient whose shared goals led to proactive rehabilitation
Kana Umamichi; Shuhei Koeda; Hiroto Imai; Chihiro Sato; Akemi Sanyoshi
The 8th Asia Pacific Occupational Therapy Congress, Nov. 2024, English, Poster presentation - 病状の認識に合わせた合意目標の設定により訓練に主体的に参加できた事例～同名半盲と注意障害を呈した事例の経験～
馬道 夏奈; 今井 寛人; 算用子 暁美; 岩田 学; 佐藤 ちひろ; 小枝 周平
第35回青森県作業療法学会, May 2024, Oral presentation - Effects of Social Isolation Stress on Cognitive and Social Behavior of Mice and Evaluation of Exercise Intervention
Kana Umamichi; Chihiro Sato; Shuhei Koeda; Tomonori Furukawa; Junko Yamada
The 4th Japan Taiwan-Korea Neurorehabilitation Conference, Mar. 2024, English, Poster presentation - The effects of social isolation stress on behavior and brain in mice.
Kana Umamichi; Chihiro Sato; Shuhei Koeda; Wataru Kobayashi; Rina Yamazaki; Junko Yamada
第46回日本神経科学大会, Aug. 2023, Poster presentation - 洗濯動作獲得による意欲の向上をきっかけに家事動作全般の獲得につながった事例 - MTDLP によるアセスメントを通して関わりの明確化ができた事例 -
馬道夏奈; 今井寛人; 小枝周平; 佐藤ちひろ; 算用子暁美
東北作業療法学会, Jul. 2022, Oral presentation
■ Academic and Social Contribution Activities/Other
Media Coverage
