Researcher basic information

• 獣医学博士, 北海道大学

• https://researchmap.jp/kida-181210?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201301063600196874
• http://kaken.nii.ac.jp/d/r/10109506.ja.html

• 201301063600196874

• インフルエンザウイルス
• ヘマグルチニン
• ワクチン
• ニュ-カッスル病ウイルス
• 病原性
• 渡り鴨
• 予測
• ブタ
• シベリア
• ヘルペスウイルス
• 営巣地
• オーエスキー病ウイルス
• 糞便
• カモ
• H5N1
• 香港
• 新型ウイルス
• インフルエンザ
• ウイルスの存続
• 渡りガモ
• 血管内皮細胞
• アジア
• 新型インフルエンザウイルス
• 渡り鳥
• ニワトリ
• 凍結湖沼水
• ニューキャッスル病ウイルス
• レセプター特異性
• 疫学調査
• 血管内血液凝固

• Life Science, Veterinary medical science
• Life Science, Virology
• Life Science, Laboratory animal science
• Life Science, Experimental pathology

Research activity information

• Dec. 2017, タマサート大学 名誉公衆衛生学博士号
  喜田 宏
• Nov. 2017, 文化功労者
  喜田 宏
• May 2017, 春の叙勲 瑞宝重光章
  喜田 宏
• Oct. 2016, 北海道功労賞
  インフルエンザウイルスの生態解明とその疾病対策
  喜田 宏
• Nov. 2011, All Japan Agriculture Decoration
  for Achievement of Control of Avian Influenza
  Hiroshi KIDA
• Feb. 2009, Animal Science Prize
  Clarification of Ecology of Influenza Viruses and Establishment of Influenza VIrus Library and its Application to the Diagnosisand Prevention of Highly Pathogenic Avian Influenza
  喜田宏
• Jun. 2005, The 95th Japan Academy Prize
  Studies for the Control of Influenza - Mechanism of Emergence of Pandemic Influenza VIrus Strains in Polutry, Domestic Animals and Humans, and Molecular Basis of the Neutralization of Viral Infectivity with Antibodies-
  喜田宏
• Apr. 2005, The Japan Prize of Agricultural Science and the Yomiuri Agriculture Prize
  Ecology of Influenza Viruses
  喜田宏
• Nov. 2004, The 58th Hokkaido Shimbun Cultural Prize
  Ecology of Influenza Viruses in Birds, Animals and Humans
  喜田宏
• Mar. 2002, Hokkaido Science and Tachnology Award
  Studies on Mechanisms of Emergence of Pandemic Influenza A Viruses and their Control Measures
  喜田宏
• Apr. 1982, The Japanese Society of Veterinary Science Award
  Studies on the Classification of Avian Paramyxoviruses
  喜田宏

• A Case of Infection with Leptospires from Three Different Serovars During a Flood in the Philippines.
  Yasutake Yanagihara; Toshiyuki Masuzawa; Masashi Shingai; Marumi Ohno; Toshiki Sekiya; Naoki Nomura; Tomomi Kawakita; Chimuka Handabile; Yuichi Koshiishi; Richard Obeng-Kyeremeh; Toshihiro Ito; Mitsumasa Saito; Sharon Y A M Villanueva; Nina G Gloriani; Hiroshi Kida
  The American journal of tropical medicine and hygiene, 113, 3, 674, 677, 03 Sep. 2025, [International Magazine]
  English, Scientific journal, Leptospirosis a significant and life-threatening zoonosis with global reach. If diagnosis and treatment are delayed, the infection may lead to fatal Weil's disease. In the Philippines, a 21-year-old man was admitted to the hospital with leptospirosis-like symptoms, including fever, myalgia, headache, anuria, jaundice, hemorrhage, skin rash, and diarrhea. Although he was immediately treated with penicillin G, the patient died shortly after admission. The serological test result was negative for Leptospira; however, three leptospires were isolated from the patient through selective cultivation under varying conditions. Microscopic agglutination tests and a phylogenetic analysis of the flaB gene encoding the flagellin subunit protein revealed that the isolates belonged to three different serovars, suggesting that the patient was simultaneously infected with at least three distinct Leptospira serovars. In this case report, we highlight the potential risk of multiple infections with leptospires in humans, a critical consideration for diagnosis and treatment strategies.
• Long-term efficacy of an inactivated H5N1 whole-particle influenza vaccine in nonhuman primates.
  Misako Nakayama; Naoko Kitagawa; Cong Thanh Nguyen; Takako Sasamura; Kyoko Takashima; Hirohito Ishigaki; Hideaki Ishida; Saori Suzuki; Yoshihiro Sakoda; Mai Quynh Le; Hiroshi Kida; Kazumasa Ogasawara; Yasushi Itoh
  NPJ vaccines, 10, 1, 164, 164, 23 Jul. 2025, [International Magazine]
  English, Scientific journal, Outbreaks of H5 highly pathogenic avian influenza A viruses (HPAIVs) in animals pose a threat to humans immunologically naïve to avian influenza viruses. However, annual vaccination, such as for seasonal influenza is not planned because the number of human patients infected with H5 HPAIVs is small, and the possibility of human-to-human transmission of H5 HPAIVs is low at present. However, various clades of H5 HPAIVs have emerged continuously. Therefore, a vaccine that confers long-term and cross-clade immunity is required. To examine the long-term effectiveness and cross-clade reactivity of an H5 influenza virus vaccine, cynomolgus macaques were infected with an H5N1 HPAIV 5 years after two subcutaneous vaccinations with inactivated H5N1 whole-virus particles (H5 clade classical/outlier), which showed higher immunogenicity than did split vaccines in our previous studies. Neutralization titers against the vaccine strain were maintained for 5 years, and a recall immune response was observed on challenge infection against the challenge strain (clade 1) and other H5N1 HPAIV strains (clades 2.2, 2.3.2.1, and 2.3.4.4b). Compared with unvaccinated macaques, viral titers were low, and the cytokine signaling pathways related to the pathogenesis of an influenza virus infection were not activated in the vaccinated macaques. Thus, a whole-virus particle vaccine induced long-term memory sufficient to prevent severe pneumonia caused by an H5N1 HPAIV in cynomolgus macaques.
• Optimization of the preparation method of inactivated intact virus particle vaccine for COVID-19.
  Marumi Ohno; Toshiki Sekiya; Richard Obeng-Kyeremeh; Chimuka Handabile; Minori Haruta; Naoki Nomura; Tomomi Kawakita; Masashi Shingai; Hiroshi Kida
  Vaccine, 56, 127173, 127173, 22 May 2025, [International Magazine]
  English, Scientific journal, It has been recognized that it is difficult to maintain the virus particle structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may be associated with lower immunogenicity of inactivated vaccines against coronavirus disease 2019 (COVID-19). We have previously demonstrated that an intact structure of the virus particles is critical for influenza inactivated whole virus particle vaccine (WPV) to be immunogenically potent. Here, we tested 37, 35, 33, and 31 °C for the virus propagation temperatures and the timing of formaldehyde treatment of the virus before and after centrifugation-based purification to obtain virus particles with an intact structure. Virus particles cultured at 33 °C retained spike proteins on the surface the most abundantly. The pretreatment of the virus with formaldehyde prevented the dissociation of the spike proteins from the viral surface during the centrifugation-based purification. The immunogenicity of the prepared vaccines, intact WPV and non-intact WPV that had lost the spike proteins, was evaluated in a mouse model. A single dose of intact WPV effectively induced humoral immunity compared to non-intact WPV, as indicated by higher titers of neutralizing antibodies. After a virus challenge, the mice vaccinated with a single dose of inactivated intact WPV showed less severe weight loss and lower virus titers in the lungs compared to those vaccinated with non-intact WPV. These results demonstrate the importance of the structural integrity of WPV in inducing effective and protective immunity, and provide significant insight into the development of COVID-19 WPV for practical use.
• ARNAX is an ideal adjuvant for COVID-19 vaccines to enhance antigen-specific CD4+ and CD8+ T-cell responses and neutralizing antibody induction.
  Tomomi Kawakita; Toshiki Sekiya; Yayoi Kameda; Naoki Nomura; Marumi Ohno; Chimuka Handabile; Akari Yamaya; Hideo Fukuhara; Yuki Anraku; Shunsuke Kita; Shinsuke Toba; Hirotake Tsukamoto; Tomohiro Sawa; Hiroyuki Oshiumi; Yasushi Itoh; Katsumi Maenaka; Akihiko Sato; Hirofumi Sawa; Yasuhiko Suzuki; Lorena E Brown; David C Jackson; Hiroshi Kida; Misako Matsumoto; Tsukasa Seya; Masashi Shingai
  Journal of virology, 99, 5, e0229024, 20 May 2025, [International Magazine]
  English, Scientific journal, UNLABELLED: ARNAX is a synthetic nucleotide-based Toll-like receptor 3 (TLR3) ligand that specifically stimulates the TLR3/TIR domain-containing adaptor molecule 1 (TICAM-1) pathway without activating inflammatory responses. ARNAX activates cellular immunity via cross-presentation; hence, its practical application has been demonstrated in cancer immunotherapy. Given the importance of cellular immunity in virus infections, ARNAX is expected to be a more effective vaccine adjuvant for virus infections than alum, an adjuvant approved for human use that mainly enhances humoral immunity. In the present study, the trimeric recombinant spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was prepared as a vaccine antigen and formulated with ARNAX. When T-cell and neutralizing antibody responses were evaluated in immunized mice, antigen formulated with ARNAX generated significantly larger numbers of antigenspecific CD4+ and CD8+ T cells, as well as higher titers of neutralizing antibodies, compared to antigen alone or antigen formulated with alum. In experiments where immunized mice were challenged with a SARS-CoV-2 mouse-adapted virus derived from the ancestral strain, immunization with antigen formulated with ARNAX reduced virus titers in the lungs at 3 days post-infection to a much greater extent than did immunization with either antigen alone or that formulated with alum. These results show that ARNAX potently enhances the levels of both cellular and humoral immunity above those seen with alum, providing significantly greater viral clearing responses. Thus, ARNAX may act as a useful adjuvant for prophylactic vaccines, particularly for viral infectious diseases. IMPORTANCE: Cellular immunity is a critical immunological defense system against virus infections. However, aluminum salts, the most widely used adjuvant for vaccines for human use, do not promote strong cellular immunity. To prepare for the next pandemic of viral origin, the development of Th1-type adjuvants with low adverse reactions that induce cellular immunity is necessary. ARNAX is a TLR3 agonist consisting of DNA-RNA hybrid nucleic acid, which is expected to be an adjuvant that induces cellular immunity. The present study using a coronavirus disease 2019 mouse model demonstrated that ARNAX potently induces cellular immunity in addition to humoral immunity with minimal induction of inflammatory cytokines. Therefore, ARNAX has the potential to be used as a potent and welltolerated adjuvant for vaccines against pandemic viruses emerging in the future.
• Single Dose of Attenuated Vaccinia Viruses Expressing H5 Hemagglutinin Affords Rapid and Long-Term Protection Against Lethal Infection with Highly Pathogenic Avian Influenza A H5N1 Virus in Mice and Monkeys.
  Fumihiko Yasui; Keisuke Munekata; Tomoko Fujiyuki; Takeshi Kuraishi; Kenzaburo Yamaji; Tomoko Honda; Sumiko Gomi; Misako Yoneda; Takahiro Sanada; Koji Ishii; Yoshihiro Sakoda; Hiroshi Kida; Shosaku Hattori; Chieko Kai; Michinori Kohara
  Vaccines, 13, 1, 15 Jan. 2025, [International Magazine]
  English, Scientific journal, BACKGROUND/OBJECTIVES: In preparation for a potential pandemic caused by the H5N1 highly pathogenic avian influenza (HPAI) virus, pre-pandemic vaccines against several viral clades have been developed and stocked worldwide. Although these vaccines are well tolerated, their immunogenicity and cross-reactivity with viruses of different clades can be improved. METHODS: To address this aspect, we generated recombinant influenza vaccines against H5-subtype viruses using two different strains of highly attenuated vaccinia virus (VACV) vectors. RESULTS: rLC16m8-mcl2.2 hemagglutinin (HA) and rLC16m8-mcl2.3.4 HA consisted of a recombinant LC16m8 vector encoding the HA protein from clade 2.2 or clade 2.3.4 viruses (respectively); rDIs-mcl2.2 HA consisted of a recombinant DIs vector encoding the HA protein from clade 2.2. A single dose of rLC16m8-mcl2.2 HA showed rapid (1 week after vaccination) and long-term protection (20 months post-vaccination) in mice against the HPAI H5N1 virus. Moreover, cynomolgus macaques immunized with rLC16m8-mcl2.2 HA exhibited long-term protection when challenged with a heterologous clade of the HPAI H5N1 virus. Although the DIs strain is unable to grow in most mammalian cells, rDIs-mcl2.2 HA also showed rapid and long-lasting effects against HPAI H5N1 virus infection. Notably, the protective efficacy of rDIs-mcl2.2 HA was comparable to that of rLC16m8-mcl2.2 HA. Furthermore, these vaccines protected animals previously immunized with VACVs from a lethal challenge with the HPAI H5N1 virus. CONCLUSIONS: These results suggest that both rLC16m8-mcl2.2 HA and rDIs-mcl2.2 HA are effective in preventing HPAI H5N1 virus infection, and rDIs-mcl2.2 HA is a promising vaccine candidate against H5 HA-subtype viruses.
• Hemagglutinin and neuraminidase of a non-pathogenic H7N7 avian influenza virus coevolved during the acquisition of intranasal pathogenicity in chickens
  Takaya Ichikawa; Takahiro Hiono; Masatoshi Okamatsu; Junki Maruyama; Daiki Kobayashi; Keita Matsuno; Hiroshi Kida; Yoshihiro Sakoda
  Archives of Virology, Oct. 2024
  English, Scientific journal
• Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaque
  Cong Thanh Nguyen; Misako Nakayama; Hirohito Ishigaki; Yoshinori Kitagawa; Akemi Kakino; Marumi Ohno; Masashi Shingai; Yasuhiko Suzuki; Tatsuya Sawamura; Hiroshi Kida; Yasushi Itoh
  Virology, 110052, 110052, Elsevier BV, Mar. 2024
  Scientific journal
• Immunogenicity and protective efficacy of a co-formulated two-in-one inactivated whole virus particle COVID-19/influenza vaccine.
  Chimuka Handabile; Marumi Ohno; Toshiki Sekiya; Naoki Nomura; Tomomi Kawakita; Mamiko Kawahara; Masafumi Endo; Tomohiro Nishimura; Minako Okumura; Shinsuke Toba; Michihito Sasaki; Yasuko Orba; Brendon Y Chua; Louise C Rowntree; Thi H O Nguyen; Masashi Shingai; Akihiko Sato; Hirofumi Sawa; Kazumasa Ogasawara; Katherine Kedzierska; Hiroshi Kida
  Scientific reports, 14, 1, 4204, 4204, 20 Feb. 2024, [International Magazine]
  English, Scientific journal, Due to the synchronous circulation of seasonal influenza viruses and severe acute respiratory coronavirus 2 (SARS-CoV-2) which causes coronavirus disease 2019 (COVID-19), there is need for routine vaccination for both COVID-19 and influenza to reduce disease severity. Here, we prepared individual WPVs composed of formalin-inactivated SARS-CoV-2 WK 521 (Ancestral strain; Co WPV) or influenza virus [A/California/07/2009 (X-179A) (H1N1) pdm; Flu WPV] to produce a two-in-one Co/Flu WPV. Serum analysis from vaccinated mice revealed that a single dose of Co/Flu WPV induced antigen-specific neutralizing antibodies against both viruses, similar to those induced by either type of WPV alone. Following infection with either virus, mice vaccinated with Co/Flu WPV showed no weight loss, reduced pneumonia and viral titers in the lung, and lower gene expression of proinflammatory cytokines, as observed with individual WPV-vaccinated. Furthermore, a pentavalent vaccine (Co/qFlu WPV) comprising of Co WPV and quadrivalent influenza vaccine (qFlu WPV) was immunogenic and protected animals from severe COVID-19. These results suggest that a single dose of the two-in-one WPV provides efficient protection against SARS-CoV-2 and influenza virus infections with no evidence of vaccine interference in mice. We propose that concomitant vaccination with the two-in-one WPV can be useful for controlling both diseases.
• Extraction of the CDRH3 sequence of the mouse antibody repertoire selected upon influenza virus infection by subtraction of the background antibody repertoire
  Masashi Shingai; Sayaka Iida; Naoko Kawai; Mamiko Kawahara; Toshiki Sekiya; Marumi Ohno; Naoki Nomura; Chimuka Handabile; Tomomi Kawakita; Ryosuke Omori; Junya Yamagishi; Kaori Sano; Akira Ainai; Tadaki Suzuki; Kazuo Ohnishi; Kimihito Ito; Hiroshi Kida
  Journal of Virology, American Society for Microbiology, 07 Feb. 2024
  Scientific journal, As specific interactions between antigens and cell-surface antibodies trigger the proliferation of B-cell clones, the frequency of each antibody sequence in the samples reflects the size of each clonal population. Nevertheless, it is extremely difficult to extract antigen-specific antibody sequences from the comprehensive bulk antibody sequences obtained from blood samples due to repertoire bias influenced by exposure to dietary antigens and other infectious agents. This issue can be addressed by subtracting the background noise from the post-immunization or post-infection repertoire data. In the present study, we propose a method to quantify repertoire data from comprehensive repertoire data. This method allowed subtraction of the background repertoire, resulting in more accurate extraction of expanded antibody repertoires upon influenza virus infection. This accurate extraction of antigen- or infection-specific repertoire information is a useful tool for vaccine evaluation.
• The impact of PA/I38 substitutions and PA polymorphisms on the susceptibility of zoonotic influenza A viruses to baloxavir.
  Keiichi Taniguchi; Takeshi Noshi; Shinya Omoto; Akihiko Sato; Takao Shishido; Keita Matsuno; Masatoshi Okamatsu; Scott Krauss; Richard J Webby; Yoshihiro Sakoda; Hiroshi Kida
  Archives of virology, 169, 2, 29, 29, 12 Jan. 2024, [International Magazine]
  English, Scientific journal, Genetic reassortment of avian, swine, and human influenza A viruses (IAVs) poses potential pandemic risks. Surveillance is important for influenza pandemic preparedness, but the susceptibility of zoonotic IAVs to the cap-dependent endonuclease inhibitor baloxavir acid (BXA) has not been thoroughly researched. Although an amino acid substitution at position 38 in the polymerase acidic protein (PA/I38) in seasonal IAVs reduces BXA susceptibility, PA polymorphisms at position 38 are rarely seen in zoonotic IAVs. Here, we examined the impact of PA/I38 substitutions on the BXA susceptibility of recombinant A(H5N1) viruses. PA mutants that harbored I38T, F, and M were 48.2-, 24.0-, and 15.5-fold less susceptible, respectively, to BXA than wild-type A(H5N1) but were susceptible to the neuraminidase inhibitor oseltamivir acid and the RNA polymerase inhibitor favipiravir. PA mutants exhibited significantly impaired replicative fitness in Madin-Darby canine kidney cells at 24 h postinfection. In addition, in order to investigate new genetic markers for BXA susceptibility, we screened geographically and temporally distinct IAVs isolated worldwide from birds and pigs. The results showed that BXA exhibited antiviral activity against avian and swine viruses with similar levels to seasonal isolates. All viruses tested in the study lacked the PA/I38 substitution and were susceptible to BXA. Isolates harboring amino acid polymorphisms at positions 20, 24, and 37, which have been implicated in the binding of BXA to the PA endonuclease domain, were also susceptible to BXA. These results suggest that monitoring of the PA/I38 substitution in animal-derived influenza viruses is important for preparedness against zoonotic influenza virus outbreaks.
• 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses.
  Kentaro Uemura; Haruaki Nobori; Akihiko Sato; Shinsuke Toba; Shinji Kusakabe; Michihito Sasaki; Koshiro Tabata; Keita Matsuno; Naoyoshi Maeda; Shiori Ito; Mayu Tanaka; Yuki Anraku; Shunsuke Kita; Mayumi Ishii; Kayoko Kanamitsu; Yasuko Orba; Yoshiharu Matsuura; William W Hall; Hirofumi Sawa; Hiroshi Kida; Akira Matsuda; Katsumi Maenaka
  Proceedings of the National Academy of Sciences of the United States of America, 120, 42, e2304139120, 17 Oct. 2023, [International Magazine]
  English, Scientific journal, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are causing significant morbidity and mortality worldwide. Furthermore, over 1 million cases of newly emerging or re-emerging viral infections, specifically dengue virus (DENV), are known to occur annually. Because no virus-specific and fully effective treatments against these or many other viruses have been approved, there is an urgent need for novel, effective therapeutic agents. Here, we identified 2-thiouridine (s2U) as a broad-spectrum antiviral ribonucleoside analogue that exhibited antiviral activity against several positive-sense single-stranded RNA (ssRNA+) viruses, such as DENV, SARS-CoV-2, and its variants of concern, including the currently circulating Omicron subvariants. s2U inhibits RNA synthesis catalyzed by viral RNA-dependent RNA polymerase, thereby reducing viral RNA replication, which improved the survival rate of mice infected with DENV2 or SARS-CoV-2 in our animal models. Our findings demonstrate that s2U is a potential broad-spectrum antiviral agent not only against DENV and SARS-CoV-2 but other ssRNA+ viruses.
• The elucidation of plasma lipidome profiles during severe influenza in a mouse model.
  Marumi Ohno; Siddabasave Gowda B Gowda; Toshiki Sekiya; Naoki Nomura; Masashi Shingai; Shu-Ping Hui; Hiroshi Kida
  Scientific reports, 13, 1, 14210, 14210, 30 Aug. 2023, [International Magazine]
  English, Scientific journal, Although influenza virus infection has been shown to affect lipid metabolism, details remain unknown. Therefore, we elucidated the kinetic lipid profiles of mice infected with different doses of influenza virus A/Puerto Rico/8/34 (H1N1) (PR8) by measuring multiple lipid molecular species using untargeted lipidomic analysis. C57BL/6 male mice were intranasally infected with PR8 virus at 50 or 500 plaque-forming units to cause sublethal or lethal influenza, respectively. Plasma and tissue samples were collected at 1, 3, and 6 days post-infection (dpi), and comprehensive lipidomic analysis was performed using high-performance liquid chromatography-linear trap quadrupole-Orbitrap mass spectrometry, as well as gene expression analyses. The most prominent feature of the lipid profile in lethally infected mice was the elevated plasma concentrations of phosphatidylethanolamines (PEs) containing polyunsaturated fatty acid (PUFA) at 3 dpi. Furthermore, the facilitation of PUFA-containing phospholipid production in the lungs, but not in the liver, was suggested by gene expression and lipidomic analysis of tissue samples. Given the increased plasma or serum levels of PUFA-containing PEs in patients with other viral infections, especially in severe cases, the elevation of these phospholipids in circulation could be a biomarker of infection and the severity of infectious diseases.
• Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques.
  Marumi Ohno; Masataka Sagata; Toshiki Sekiya; Naoki Nomura; Masashi Shingai; Masafumi Endo; Kazuhiko Kimachi; Saori Suzuki; Cong Thanh Nguyen; Misako Nakayama; Hirohito Ishigaki; Kazumasa Ogasawara; Yasushi Itoh; Yoichiro Kino; Hiroshi Kida
  Vaccine, 41, 3, 787, 794, 16 Jan. 2023, [International Magazine]
  English, Scientific journal, Among inactivated influenza vaccines, the whole virus particle vaccine (WPV) elicits superior priming responses to split virus vaccine (SV) in efficiently inducing humoral and cellular immunity. However, there is concern for undesired adverse events such as fever for WPV due to its potent immunogenicity. Therefore, this study investigated the febrile response induced by subcutaneous injection with quadrivalent inactivated influenza vaccines of good manufacturing grade for pharmaceutical or investigational products in cynomolgus macaques. Body temperature was increased by 1 °C-2 °C for 6-12 h after WPV administration at the first vaccination but not at the second shot, whereas SV did not affect body temperature at both points. Given the potent priming ability of WPV, WPV-induced fever may be attributed to immune responses that uniquely occur during priming. Since WPV-induced fever was blunted by pretreatment with indomethacin (a cyclooxygenase inhibitor), the febrile response by WPV is considered to depend on the increase in prostaglandins synthesized by cyclooxygenase. In addition, WPV, but not SV, induced the elevation of type I interferons and monocyte chemotactic protein 1 in the plasma; these factors may be responsible for pyrogenicity caused by WPV, as they can increase prostaglandins in the brain. Notably, sufficient antibody responses were acquired by half the amount of WPV without causing fever, suggesting that excessive immune responses to trigger the febrile response is not required for acquired immunity induction. Thus, we propose that WPV with a reduced antigen dose should be evaluated for potential clinical usage, especially in naïve populations.
• Effects of chondroitin sulfate oligosaccharides on osteoclast differentiation of RAW264 cells, and myotube differentiation of C2C12 cells.
  Hirofumi Uchiyama; Daisuke Muramatsu; Hideaki Higashi; Hiroshi Kida; Atsushi Iwai
  PloS one, 18, 4, e0284343, 2023, [International Magazine]
  English, Scientific journal, Chondroitin sulfate (CS) is a glycosaminoglycan, and CS derived from various animal species is used in drugs and food supplements to alleviate arthralgia. The CS is a high molecular weight compound, and hydrolysis of CS by intestinal microbiota is thought to be required for absorption in mammalians. Chondroitin sulfate oligosaccharides (Oligo-CS) are produced by hydrolysis with subcritical water from CS isolated from a species of skate, Raja pulchra for the improvement of bioavailability. The present study conducted in vitro experiments using murine cell lines, to compare the biological activities of Oligo-CS and high molecular weight CS composed with the similar disaccharide isomer units of D-glucuronic acid and N-acetyl-D-glucosamine (CS-C). The results show that Oligo-CS inhibits osteoclast differentiation of RAW264 cells significantly at lower concentrations than in CS. The cell viability of a myoblast cell line, C2C12 cells, was increased when the cells were grown in a differentiated medium for myotubes with Oligo-CS, where there were no effects on the cell viability in CS. These results suggest that in vitro Oligo-CS exhibits stronger bioactivity than high-molecular weight CS.
• Effects of heat degradation of betanin in red beetroot (Beta vulgaris L.) on biological activity and antioxidant capacity.
  Daisuke Muramatsu; Hirofumi Uchiyama; Hideaki Higashi; Hiroshi Kida; Atsushi Iwai
  PloS one, 18, 5, e0286255, 2023, [International Magazine]
  English, Scientific journal, Betanin is a red pigment of red beetroot (Beta vulgaris L.), providing the beneficial effects to maintain human health. Betanin is involved in the characteristic red color of red beetroot, and used as an edible dye. Betanin is known to be a highly unstable pigment, and water solutions of betanin are nearly fully degraded after heating at 99°C for 60 min in the experimental conditions of this study. The present study investigated the effects of red beetroot juice (RBJ) and betanin on immune cells, and found that stimulation with RBJ and betanin induces interleukin (IL)-1β, IL-8, and IL-10 mRNA in a human monocyte derived cell line, THP-1 cells. This mRNA induction after stimulation with RBJ and betanin was not significantly changed after heat treatment when attempting to induce degradation of the betanin. Following these results, the effects of heat degradation of betanin on the inhibition of lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264 cells and the antioxidant capacity were investigated. The results showed that the inhibition activity of RBJ and betanin with the LPS induced NO production is not altered after heat degradation of betanin. In addition, the results of FRAP (ferric reducing antioxidant power) and DPPH (1,1-Diphenyl-2-picrylhydrazyl) assays indicate that a not inconsiderable degree of the antioxidant capacity of RBJ and betanin remained after heat degradation of betanin. These results suggest that it is important to consider the effects of degradation products of betanin in the evaluation of the beneficial effects of red beetroot on health.
• Field-deployable multiplex detection method of SARS-CoV-2 and influenza virus using loop-mediated isothermal amplification and DNA chromatography.
  Kyoko Hayashida; Alejandro Garcia; Lavel Chinyama Moonga; Tatsuki Sugi; Kodera Takuya; Mitsuo Kawase; Fumihiro Kodama; Atsushi Nagasaka; Nobuhisa Ishiguro; Ayato Takada; Masahiro Kajihara; Naganori Nao; Masashi Shingai; Hiroshi Kida; Yasuhiko Suzuki; William W Hall; Hirofumi Sawa; Junya Yamagishi
  PloS one, 18, 5, e0285861, 2023, [International Magazine]
  English, Scientific journal, A novel multiplex loop-mediated isothermal amplification (LAMP) method combined with DNA chromatography was developed for the simultaneous detection of three important respiratory disease-causing viruses: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus, and influenza B virus. Amplification was performed at a constant temperature, and a positive result was confirmed by a visible colored band. An in-house drying protocol with trehalose was used to prepare the dried format multiplex LAMP test. Using this dried multiplex LAMP test, the analytical sensitivity was determined to be 100 copies for each viral target and 100-1000 copies for the simultaneous detection of mixed targets. The multiplex LAMP system was validated using clinical COVID-19 specimens and compared with the real-time qRT-PCR method as a reference test. The determined sensitivity of the multiplex LAMP system for SARS-CoV-2 was 71% (95% CI: 0.62-0.79) for cycle threshold (Ct) ≤ 35 samples and 61% (95% CI: 0.53-0.69) for Ct ≤40 samples. The specificity was 99% (95%CI: 0.92-1.00) for Ct ≤35 samples and 100% (95%CI: 0.92-1.00) for the Ct ≤40 samples. The developed simple, rapid, low-cost, and laboratory-free multiplex LAMP system for the two major important respiratory viral diseases, COVID-19 and influenza, is a promising field-deployable diagnosis tool for the possible future 'twindemic, ' especially in resource-limited settings.
• Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques.
  Brendon Y Chua; Toshiki Sekiya; Marios Koutsakos; Naoki Nomura; Louise C Rowntree; Thi H O Nguyen; Hayley A McQuilten; Marumi Ohno; Yuki Ohara; Tomohiro Nishimura; Masafumi Endo; Yasushi Itoh; Jennifer R Habel; Kevin J Selva; Adam K Wheatley; Bruce D Wines; P Mark Hogarth; Stephen J Kent; Amy W Chung; David C Jackson; Lorena E Brown; Masashi Shingai; Katherine Kedzierska; Hiroshi Kida
  PLoS pathogens, 18, 10, e1010891, Oct. 2022, [International Magazine]
  English, Scientific journal, Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their efficacy can be modest, especially in immunologically-naïve individuals. We investigated immune responses towards inactivated whole influenza virus particle vaccine (WPV) formulations, predicated to be more immunogenic, in a non-human primate model, as an important step towards clinical testing in humans. Comprehensive analyses were used to capture 46 immune parameters to profile how WPV-induced responses differed to those elicited by antigenically-similar SV formulations. Naïve cynomolgus macaques vaccinated with either monovalent or quadrivalent WPV consistently induced stronger antibody responses and hemagglutination inhibition (HI) antibody titres against vaccine-matched viruses compared to SV formulations, while acute reactogenic effects were similar. Responses in WPV-primed animals were further increased by boosting with the same formulation, conversely to modest responses after priming and boosting with SV. 28-parameter multiplex bead array defined key antibody features and showed that while both WPV and SV induced elevated IgG responses against A/H1N1 nucleoprotein, only WPV increased IgG responses against A/H1N1 hemagglutinin (HA) and HA-Stem, and higher IgA responses to A/H1N1-HA after each vaccine dose. Antibodies to A/H1N1-HA and HA-Stem that could engage FcγR2a and FcγR3a were also present at higher levels after one dose of WPV compared to SV and remained elevated after the second dose. Furthermore, WPV-enhanced antibody responses were associated with higher frequencies of HA-specific B-cells and IFN-γ-producing CD4+ T-cell responses. Our data additionally demonstrate stronger boosting of HI titres by WPV following prior infection and support WPV administered as a priming dose irrespective of the follow up vaccine for the second dose. Our findings thus show that compared to SV vaccination, WPV-induced humoral responses are significantly increased in scope and magnitude, advocating WPV vaccination regimens for priming immunologically-naïve individuals and also in the event of a pandemic outbreak.
• Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses.
  Shinsuke Toba; Akihiko Sato; Makoto Kawai; Yoshiyuki Taoda; Yuto Unoh; Shinji Kusakabe; Haruaki Nobori; Shota Uehara; Kentaro Uemura; Keiichi Taniguchi; Masanori Kobayashi; Takeshi Noshi; Ryu Yoshida; Akira Naito; Takao Shishido; Junki Maruyama; Slobodan Paessler; Michael J Carr; William W Hall; Kumiko Yoshimatsu; Jiro Arikawa; Keita Matsuno; Yoshihiro Sakoda; Michihito Sasaki; Yasuko Orba; Hirofumi Sawa; Hiroshi Kida
  Proceedings of the National Academy of Sciences of the United States of America, 119, 36, e2206104119, 06 Sep. 2022, [International Magazine]
  English, Scientific journal, Viral hemorrhagic fevers caused by members of the order Bunyavirales comprise endemic and emerging human infections that are significant public health concerns. Despite the disease severity, there are few therapeutic options available, and therefore effective antiviral drugs are urgently needed to reduce disease burdens. Bunyaviruses, like influenza viruses (IFVs), possess a cap-dependent endonuclease (CEN) that mediates the critical cap-snatching step of viral RNA transcription. We screened compounds from our CEN inhibitor (CENi) library and identified specific structural compounds that are 100 to 1,000 times more active in vitro than ribavirin against bunyaviruses, including Lassa virus, lymphocytic choriomeningitis virus (LCMV), and Junin virus. To investigate their inhibitory mechanism of action, drug-resistant viruses were selected in culture. Whole-genome sequencing revealed that amino acid substitutions in the CEN region of drug-resistant viruses were located in similar positions as those of the CEN α3-helix loop of IFVs derived under drug selection. Thus, our studies suggest that CENi compounds inhibit both bunyavirus and IFV replication in a mechanistically similar manner. Structural analysis revealed that the side chain of the carboxyl group at the seventh position of the main structure of the compound was essential for the high antiviral activity against bunyaviruses. In LCMV-infected mice, the compounds significantly decreased blood viral load, suppressed symptoms such as thrombocytopenia and hepatic dysfunction, and improved survival rates. These data suggest a potential broad-spectrum clinical utility of CENis for the treatment of both severe influenza and hemorrhagic diseases caused by bunyaviruses.
• Inactivated whole influenza virus particle vaccines induce neutralizing antibodies with an increase in immunoglobulin gene subclones of B-lymphocytes in cynomolgus macaques.
  Masanori Shiohara; Saori Suzuki; Shintaro Shichinohe; Hirohito Ishigaki; Misako Nakayama; Naoki Nomura; Masashi Shingai; Toshiki Sekiya; Marumi Ohno; Sayaka Iida; Naoko Kawai; Mamiko Kawahara; Junya Yamagishi; Kimihito Ito; Ryotarou Mitsumata; Tomio Ikeda; Kenji Motokawa; Tomoyoshi Sobue; Hiroshi Kida; Kazumasa Ogasawara; Yasushi Itoh
  Vaccine, 40, 30, 4026, 4037, 26 Jun. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, The All-Japan Influenza Vaccine Study Group has been developing a more effective vaccine than the current split vaccines for seasonal influenza virus infection. In the present study, the efficacy of formalin- and/or β-propiolactone-inactivated whole virus particle vaccines for seasonal influenza was compared to that of the current ether-treated split vaccines in a nonhuman primate model. The monovalent whole virus particle vaccines or split vaccines of influenza A virus (H1N1) and influenza B virus (Victoria lineage) were injected subcutaneously into naïve cynomolgus macaques twice. The whole virus particle vaccines induced higher titers of neutralizing antibodies against H1N1 influenza A virus and influenza B virus in the plasma of macaques than did the split vaccines. At challenge with H1N1 influenza A virus or influenza B virus, the virus titers in nasal swabs and the increases in body temperatures were lower in the macaques immunized with the whole virus particle vaccine than in those immunized with the split vaccine. Repertoire analyses of immunoglobulin heavy chain genes demonstrated that the number of B-lymphocyte subclones was increased in macaques after the 1st vaccination with the whole virus particle vaccine, but not with the split vaccine, indicating that the whole virus particle vaccine induced the activation of vaccine antigen-specific B-lymphocytes more vigorously than did the split vaccine at priming. Thus, the present findings suggest that the superior antibody induction ability of the whole virus particle vaccine as compared to the split vaccine is attributable to its stimulatory properties on the subclonal differentiation of antigen-specific B-lymphocytes.
• Inactivated Whole Virus Particle Influenza Vaccine Induces Anti-Neuraminidase Antibodies That May Contribute to Cross-Protection against Heterologous Virus Infection.
  Chimuka Handabile; Toshiki Sekiya; Naoki Nomura; Marumi Ohno; Tomomi Kawakita; Masashi Shingai; Hiroshi Kida
  Vaccines, 10, 5, 19 May 2022, [International Magazine]
  English, Scientific journal, Despite the use of vaccines, seasonal influenza remains a risk to public health. We previously proposed the inactivated whole virus particle vaccine (WPV) as an alternative to the widely used split vaccine (SV) for the control of seasonal and pandemic influenza based on the superior priming potency of WPV to that of SV. In this study, we further examined and compared the immunological potency of monovalent WPV and SV of A/California/7/2009 (X-179A) (H1N1) pdm09 (CA/09) to generate immune responses against heterologous viruses, A/Singapore/GP1908/2015 (IVR-180) (H1N1) pdm09 (SG/15), and A/duck/Hokkaido/Vac-3/2007 (H5N1) (DH/07) in mice. Following challenge with a lethal dose of heterologous SG/15, lower virus titer in the lungs and milder weight loss were observed in WPV-vaccinated mice than in SV-vaccinated ones. To investigate the factors responsible for the differences in the protective effect against SG/15, the sera of vaccinated mice were analyzed by hemagglutination-inhibition (HI) and neuraminidase-inhibition (NI) assays to evaluate the antibodies induced against viral hemagglutinin (HA) and neuraminidase (NA), respectively. While the two vaccines induced similar levels of HI antibodies against SG/15 after the second vaccination, only WPV-vaccinated mice induced significantly higher titers of NI antibodies against the strain. Furthermore, given the significant elevation of NI antibody titers against DH/07, an H5N1 avian influenza virus, WPV was also demonstrated to induce NA-inhibiting antibodies that recognize NA of divergent strains. This could be explained by the higher conservation of epitopes of NA among strains than for HA. Taking these findings together, NA-specific antibodies induced by WPV may have contributed to better protection from infection with heterologous influenza virus SG/15, compared with SV. The present results indicate that WPV is an effective vaccine for inducing antibodies against both HA and NA of heterologous viruses and may be a useful vaccine to conquer vaccine strain mismatch.
• Leptospira Is an environmental bacterium that grows in waterlogged soil.
  Yasutake Yanagihara; Sharon Y A M Villanueva; Naoki Nomura; Marumi Ohno; Toshiki Sekiya; Chimuka Handabile; Masashi Shingai; Hideaki Higashi; Shin-Ichi Yoshida; Toshiyuki Masuzawa; Nina G Gloriani; Mitsumasa Saito; Hiroshi Kida
  Microbiology Spectrum, 10, 2, e0215721, 15 Mar. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Leptospirosis is a zoonotic disease caused by infection with pathogenic leptospires. Consistent with recent studies by other groups, leptospires were isolated from 89 out of 110 (80.9%) soil or water samples from varied locations in the Philippines in our surveillance study, indicating that leptospires might have a life cycle that does not involve animal hosts. However, despite previous work, it has not been confirmed whether leptospires multiply in the soil environment under various experimental conditions. Given the fact that the case number of leptospirosis is increased after flood, we hypothesized that waterlogged soil, which mimics the postflooding environment, could be a suitable condition for growing leptospires. To verify this hypothesis, pathogenic and saprophytic leptospires were seeded in the bottles containing 2.5 times as much water as soil, and bacterial counts in the bottles were measured over time. Pathogenic and saprophytic leptospires were found to increase their number in waterlogged soil but not in water or soil alone. In addition, leptospires were reisolated from soil in closed tubes for as long as 379 days. These results indicate that leptospires are in a resting state in the soil and are able to proliferate with increased water content in the environment. This notion is strongly supported by observations that the case number of leptospirosis is significantly higher in rainy seasons and increased after flood. Therefore, we reached the following conclusion: environmental soil is a potential reservoir of leptospires. IMPORTANCE Since research on Leptospira has focused on pathogenic leptospires, which are supposed to multiply only in animal hosts, the life cycle of saprophytic leptospires has long been a mystery. This study demonstrates that both pathogenic and saprophytic leptospires multiply in the waterlogged soil, which mimics the postflooding environment. The present results potentially explain why leptospirosis frequently occurs after floods. Therefore, environmental soil is a potential reservoir of leptospires and leptospirosis is considered an environment-borne as well as a zoonotic disease. This is a significant report to reveal that leptospires multiply under environmental conditions, and this finding leads us to reconsider the ecology of leptospires.
• Characterization of the In Vitro and In Vivo Efficacy of Baloxavir Marboxil against H5 Highly Pathogenic Avian Influenza Virus Infection.
  Keiichi Taniguchi; Yoshinori Ando; Masanori Kobayashi; Shinsuke Toba; Haruaki Nobori; Takao Sanaki; Takeshi Noshi; Makoto Kawai; Ryu Yoshida; Akihiko Sato; Takao Shishido; Akira Naito; Keita Matsuno; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida
  Viruses, 14, 1, 08 Jan. 2022, [International Magazine]
  English, Scientific journal, Human infections caused by the H5 highly pathogenic avian influenza virus (HPAIV) sporadically threaten public health. The susceptibility of HPAIVs to baloxavir acid (BXA), a new class of inhibitors for the influenza virus cap-dependent endonuclease, has been confirmed in vitro, but it has not yet been fully characterized. Here, the efficacy of BXA against HPAIVs, including recent H5N8 variants, was assessed in vitro. The antiviral efficacy of baloxavir marboxil (BXM) in H5N1 virus-infected mice was also investigated. BXA exhibited similar in vitro activities against H5N1, H5N6, and H5N8 variants tested in comparison with seasonal and other zoonotic strains. Compared with oseltamivir phosphate (OSP), BXM monotherapy in mice infected with the H5N1 HPAIV clinical isolate, the A/Hong Kong/483/1997 strain, also caused a significant reduction in viral titers in the lungs, brains, and kidneys, thereby preventing acute lung inflammation and reducing mortality. Furthermore, compared with BXM or OSP monotherapy, combination treatments with BXM and OSP using a 48-h delayed treatment model showed a more potent effect on viral replication in the organs, accompanied by improved survival. In conclusion, BXM has a potent antiviral efficacy against H5 HPAIV infections.
• Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model
  Marumi Ohno; Akemi Kakino; Toshiki Sekiya; Naoki Nomura; Masashi Shingai; Tatsuya Sawamura; Hiroshi Kida
  Scientific Reports, 11, 1, Dec. 2021
  Scientific journal
• Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
  Makoto Saito; Yasushi Itoh; Fumihiko Yasui; Tsubasa Munakata; Daisuke Yamane; Makoto Ozawa; Risa Ito; Takayuki Katoh; Hirohito Ishigaki; Misako Nakayama; Shintaro Shichinohe; Kenzaburo Yamaji; Naoki Yamamoto; Ai Ikejiri; Tomoko Honda; Takahiro Sanada; Yoshihiro Sakoda; Hiroshi Kida; Thi Quynh Mai Le; Yoshihiro Kawaoka; Kazumasa Ogasawara; Kyoko Tsukiyama-Kohara; Hiroaki Suga; Michinori Kohara
  Nature Communications, 12, 1, Springer Science and Business Media LLC, Dec. 2021
  Scientific journal, Most anti-influenza drugs currently used, such as oseltamivir and zanamivir, inhibit the enzymatic activity of neuraminidase. However, neuraminidase inhibitor-resistant viruses have already been identified from various influenza virus isolates. Here, we report the development of a class of macrocyclic peptides that bind the influenza viral envelope protein hemagglutinin, named iHA. Of 28 iHAs examined, iHA-24 and iHA-100 have inhibitory effects on the in vitro replication of a wide range of Group 1 influenza viruses. In particular, iHA-100 bifunctionally inhibits hemagglutinin-mediated adsorption and membrane fusion through binding to the stalk domain of hemagglutinin. Moreover, iHA-100 shows powerful efficacy in inhibiting the growth of highly pathogenic influenza viruses and preventing severe pneumonia at later stages of infection in mouse and non-human primate cynomolgus macaque models. This study shows the potential for developing cyclic peptides that can be produced more efficiently than antibodies and have multiple functions as next-generation, mid-sized biomolecules.
• Abnormal blood coagulation and kidney damage in aged hamsters infected with severe acute respiratory syndrome coronavirus 2
  Marumi Ohno; Michihito Sasaki; Yasuko Orba; Toshiki Sekiya; Md Abdul Masum; Osamu Ichii; Tatsuya Sawamura; Akemi Kakino; Yasuhiko Suzuki; Hiroshi Kida; Hirofumi Sawa; Masashi Shingai
  Viruses, 13, 11, Nov. 2021
  Scientific journal
• Defining the kinetic effects of infection with influenza virus A/PR8/34 (H1N1) on sphingosine-1-phosphate signaling in mice by targeted LC/MS.
  Divyavani Gowda; Marumi Ohno; Siddabasave Gowda B Gowda; Hitoshi Chiba; Masashi Shingai; Hiroshi Kida; Shu-Ping Hui
  Scientific reports, 11, 1, 20161, 20161, 11 Oct. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Influenza remains a world-wide health concern, causing 290,000-600,000 deaths and up to 5 million cases of severe illnesses annually. Noticing the host factors that control biological responses, such as inflammatory cytokine secretion, to influenza virus infection is important for the development of novel drugs. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite and has essential biological functions in inflammation. However, the kinetic effects of influenza virus infection on physiological S1P levels and their signaling in multiple tissues remain unknown. In this study, we utilized a mouse model intranasally infected with 50 or 500 plaque forming units (PFU) of A/Puerto Rico/8/34 (H1N1; PR8) virus to investigate how S1P levels and expression of its regulating factors are affected by influenza virus infection by the liquid-chromatography/mass spectrometry and real-time PCR, respectively. The S1P level was significantly high in the plasma of mice infected with 500 PFU of the virus than that in control mice at 6 day-post-infection (dpi). Elevated gene expression of sphingosine kinase-1 (Sphk1), an S1P synthase, was observed in the liver, lung, white adipose tissue, heart, and aorta of infected mice. This could be responsible for the increased plasma S1P levels as well as the decrease in the hepatic S1P lyase (Sgpl1) gene in the infected mice. These results indicate modulation of S1P-signaling by influenza virus infection. Since S1P regulates inflammation and leukocyte migration, it must be worth trying to target this signaling to control influenza-associated symptoms.
• Sulfated glycans containing NeuAcα2-3Gal facilitate the propagation of human H1N1 influenza A viruses in eggs
  Tomomi Ichimiya; Masatoshi Okamatsu; Takaaki Kinoshita; Daiki Kobayashi; Osamu Ichii; Naoki Yamamoto; Yoshihiro Sakoda; Hiroshi Kida; Hiroto Kawashima; Kazuo Yamamoto; Sayaka Takase-Yoden; Shoko Nishihara
  Virology, 562, 29, 39, Elsevier BV, Oct. 2021
  Scientific journal
• Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells.
  Masashi Shingai; Naoki Nomura; Toshiki Sekiya; Marumi Ohno; Daisuke Fujikura; Chimuka Handabile; Ryosuke Omori; Yuki Ohara; Tomohiro Nishimura; Masafumi Endo; Kazuhiko Kimachi; Ryotarou Mitsumata; Tomio Ikeda; Hiroki Kitayama; Hironori Hatanaka; Tomoyoshi Sobue; Fumihito Muro; Saori Suzuki; Cong Thanh Nguyen; Hirohito Ishigaki; Misako Nakayama; Yuya Mori; Yasushi Itoh; Marios Koutsakos; Brendon Y Chua; Katherine Kedzierska; Lorena E Brown; David C Jackson; Kazumasa Ogasawara; Yoichiro Kino; Hiroshi Kida
  Vaccine, 39, 29, 3940, 3951, 29 Jun. 2021, [International Magazine]
  English, Scientific journal, Current detergent or ether-disrupted split vaccines (SVs) for influenza do not always induce adequate immune responses, especially in young children. This contrasts with the whole virus particle vaccines (WPVs) originally used against influenza that were immunogenic in both adults and children but were replaced by SV in the 1970s due to concerns with reactogenicity. In this study, we re-evaluated the immunogenicity of WPV and SV, prepared from the same batch of purified influenza virus, in cynomolgus macaques and confirmed that WPV is superior to SV in priming potency. In addition, we compared the ability of WPV and SV to induce innate immune responses, including the maturation of dendritic cells (DCs) in vitro. WPV stimulated greater production of inflammatory cytokines and type-I interferon in immune cells from mice and macaques compared to SV. Since these innate responses are likely triggered by the activation of pattern recognition receptors (PRRs) by viral RNA, the quantity and quality of viral RNA in each vaccine were assessed. Although the quantity of viral RNA was similar in the two vaccines, the amount of viral RNA of a length that can be recognized by PRRs was over 100-fold greater in WPV than in SV. More importantly, 1000-fold more viral RNA was delivered to DCs by WPV than by SV when exposed to preparations containing the same amount of HA protein. Furthermore, WPV induced up-regulation of the DC maturation marker CD86 on murine DCs, while SV did not. The present results suggest that the activation of antigen-presenting DCs, by PRR-recognizable viral RNA contained in WPV is responsible for the effective priming potency of WPV observed in naïve mice and macaques. WPV is thus recommended as an alternative option for seasonal influenza vaccines, especially for children.
• The clinically used serine protease inhibitor nafamostat reduces influenza virus replication and cytokine production in human airway epithelial cells and viral replication in mice.
  Mutsuo Yamaya; Yoshitaka Shimotai; Ayako Ohkawara; Enkhbold Bazarragchaa; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Hidekazu Nishimura
  Journal of medical virology, 93, 6, 3484, 3495, Jun. 2021, [International Magazine]
  English, Scientific journal, The effects of the clinically used protease inhibitor nafamostat on influenza virus replication have not been well studied. Primary human tracheal (HTE) and nasal (HNE) epithelial cells were pretreated with nafamostat and infected with the 2009 pandemic [A/Sendai-H/108/2009/(H1N1) pdm09] or seasonal [A/New York/55/2004(H3N2)] influenza virus. Pretreatment with nafamostat reduced the titers of the pandemic and seasonal influenza viruses and the secretion of inflammatory cytokines, including interleukin-6 and tumor necrosis factor-α, in the supernatants of the cells infected with the pandemic influenza virus. HTE and HNE cells exhibited mRNA and/or protein expression of transmembrane protease serine 2 (TMPRSS2), TMPRSS4, and TMPRSS11D. Pretreatment with nafamostat reduced cleavage of the precursor protein HA0 of the pandemic influenza virus into subunit HA1 in HTE cells and reduced the number of acidic endosomes in HTE and HNE cells where influenza virus RNA enters the cytoplasm. Additionally, nafamostat (30 mg/kg/day, intraperitoneal administration) reduced the levels of the pandemic influenza virus [A/Hyogo/YS/2011 (H1N1) pdm09] in mouse lung washes. These findings suggest that nafamostat may inhibit influenza virus replication in human airway epithelial cells and mouse lungs and reduce infection-induced airway inflammation by modulating cytokine production.
• Updating the influenza virus library at Hokkaido University -It's potential for the use of pandemic vaccine strain candidates and diagnosis.
  Naoki Nomura; Keita Matsuno; Masashi Shingai; Marumi Ohno; Toshiki Sekiya; Ryosuke Omori; Yoshihiro Sakoda; Robert G Webster; Hiroshi Kida
  Virology, 557, 55, 61, May 2021, [International Magazine]
  English, Scientific journal, Genetic reassortment of influenza A viruses through cross-species transmission contributes to the generation of pandemic influenza viruses. To provide information on the ecology of influenza viruses, we have been conducting a global surveillance of zoonotic influenza and establishing an influenza virus library. Of 4580 influenza virus strains in the library, 3891 have been isolated from over 70 different bird species. The remaining 689 strains were isolated from humans, pigs, horses, seal, whale, and the environment. Phylogenetic analyses of the HA genes of the library isolates demonstrate that the library strains are distributed to all major known clusters of the H1, H2 and H3 subtypes of HA genes that are prevalent in humans. Since past pandemic influenza viruses are most likely genetic reassortants of zoonotic and seasonal influenza viruses, a vast collection of influenza A virus strains from various hosts should be useful for vaccine preparation and diagnosis for future pandemics.
• H5N1高病原性鳥インフルエンザウイルスの膜透過性ペプチドを介した細胞侵入機構
  梶原 直樹; 山本 直樹; 小原 道法; 安井 文彦; 迫田 義博; 喜田 宏; 芝崎 太
  日本薬学会年会要旨集, 141年会, 28P01, L006, (公社)日本薬学会, Mar. 2021
  Japanese
• Efficacy of a Cap-Dependent Endonuclease Inhibitor and Neuraminidase Inhibitors against H7N9 Highly Pathogenic Avian Influenza Virus Causing Severe Viral Pneumonia in Cynomolgus Macaques.
  Saori Suzuki; Cong Thanh Nguyen; Ayako Ogata-Nakahara; Akihiro Shibata; Hiroyuki Osaka; Hirohito Ishigaki; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara; Yasushi Itoh
  Antimicrobial agents and chemotherapy, 65, 3, 17 Feb. 2021, [International Magazine]
  English, Scientific journal, H7N9 highly pathogenic avian influenza virus (HPAIV) infection in a human was first reported in 2017. A/duck/Japan/AQ-HE29-22/2017 (H7N9) (Dk/HE29-22), found in imported duck meat at an airport in Japan, possesses a hemagglutinin with a multibasic cleavage site, indicating high pathogenicity in chickens, as in the case of other H7 HPAIVs. In the present study, we examined the pathogenicity of Dk/HE29-22 and the effectiveness of a cap-dependent endonuclease inhibitor (baloxavir) and neuraminidase inhibitors (oseltamivir and zanamivir) against infection with this strain in a macaque model (n = 3 for each group). All of the macaques infected with Dk/HE29-22 showed severe signs of disease and pneumonia even after the virus had disappeared from lung samples. Virus titers in macaques treated with baloxavir were significantly lower than those in the other treated groups. After infection, levels of interferon alpha and beta (IFN-α and IFN-β) in the blood of macaques in the baloxavir group were the highest among the groups, whereas levels of tumor necrosis factor alpha (TNF-α) and interleukin 13 (IL-13) were slightly increased in the untreated group. In addition, immune checkpoint proteins, including programmed death 1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT), were expressed at high levels in the untreated group, especially in one macaque that showed severe signs of disease, indicating that negative feedback responses against vigorous inflammation may contribute to disease progression. In the group treated with baloxavir, the percentages of PD-1-, CTLA-4-, and TIGIT-positive T lymphocytes were lower than those in the untreated group, indicating that reduction in virus titers may prevent expression of immune checkpoint molecules from downregulation of T cell responses.
• Potency of an Inactivated Influenza Vaccine against a Challenge with A/Swine/Missouri/A01727926/2015 (H4N6) in Mice for Pandemic Preparedness.
  Hirotaka Hayashi; Norikazu Isoda; Enkhbold Bazarragchaa; Naoki Nomura; Keita Matsuno; Masatoshi Okamatsu; Hiroshi Kida; Yoshihiro Sakoda
  Vaccines, 8, 4, 16 Dec. 2020, [International Magazine]
  English, Scientific journal, H4 influenza viruses have been isolated from birds across the world. In recent years, an H4 influenza virus infection has been confirmed in pigs. Pigs play an important role in the transmission of influenza viruses to human hosts. Therefore, it is important to develop a new vaccine in the case of an H4 influenza virus infection in humans, considering that this virus has a different antigenicity from seasonal human influenza viruses. In this study, after selecting vaccine candidate strains based on their antigenic relation to one of the pig isolates, A/swine/Missouri/A01727926/2015 (H4N6) (MO/15), an inactivated whole-particle vaccine was prepared from A/swan/Hokkaido/481102/2017 (H4N6). This vaccine showed high immunogenicity in mice, and the antibody induced by the vaccine showed high cross-reactivity to the MO/15 virus. This vaccine induced sufficient neutralizing antibodies and mitigated the effects of an MO/15 infection in a mouse model. This study is the first to suggest that an inactivated whole-particle vaccine prepared from an influenza virus isolated from wild birds is an effective countermeasure in case of a future influenza pandemic caused by the H4 influenza virus.
• Re-Invasion of H5N8 High Pathogenicity Avian Influenza Virus Clade 2.3.4.4b in Hokkaido, Japan, 2020.
  Norikazu Isoda; Augustin T Twabela; Enkhbold Bazarragchaa; Kohei Ogasawara; Hirotaka Hayashi; Zu-Jyun Wang; Daiki Kobayashi; Yukiko Watanabe; Keisuke Saito; Hiroshi Kida; Yoshihiro Sakoda
  Viruses, 12, 12, 14 Dec. 2020, [International Magazine]
  English, Scientific journal, Global dispersion of high pathogenicity avian influenza (HPAI), especially that caused by H5 clade 2.3.4.4, has threatened poultry industries and, potentially, human health. An HPAI virus, A/northern pintail/Hokkaido/M13/2020 (H5N8) (NP/Hok/20) belonging to clade 2.3.4.4b, was isolated from a fecal sample collected at a lake in Hokkaido, Japan where migratory birds rested, October 2020. In the phylogenetic trees of all eight gene segments, NP/Hok/20 fell into in the cluster of European isolates in 2020, but was distinct from the isolates in eastern Asia and Europe during the winter season of 2017-2018. The antigenic cartography indicates that the antigenicity of NP/Hok/20 was almost the same as that of previous isolates of H5 clade 2.3.4.4b, whereas the antigenic distances from NP/Hok/20 to the representative strains in clade 2.3.4.4e and to a strain in 2.3.4 were apparently distant. These data imply that HPAI virus clade 2.3.4.4b should have been delivered by bird migration despite the intercontinental distance, although it was not defined whether NP/Hok/20 was transported from Europe via Siberia where migratory birds nest in the summer season. Given the probability of perpetuation of transmission in the northern territory, periodic updates of intensive surveys on avian influenza at the global level are essential to prepare for future outbreaks of the HPAI virus.
• In vitro anti-inflammatory and anti-lipid accumulation properties of taxifolin-rich extract from the Japanese larch, Larix kaempferi
  Daisuke Muramatsu; Hirofumi Uchiyama; Hiroshi Kida; Atsushi Iwai
  Heliyon, 6, 12, e05505, e05505, Elsevier BV, Dec. 2020
  Scientific journal
• Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus
  Naoki Kajiwara; Namiko Nomura; Masako Ukaji; Naoki Yamamoto; Michinori Kohara; Fumihiko Yasui; Yoshihiro Sakoda; Hiroshi Kida; Futoshi Shibasaki
  Scientific Reports, 10, 1, Springer Science and Business Media LLC, Dec. 2020
  Scientific journal,
  H5N1 highly pathogenic avian influenza virus (HPAIV) poses a huge threat to public health and the global economy. These viruses cause systemic infection in poultry and accidental human infection leads to severe pneumonia, associated with high mortality rates. The hemagglutinin (HA) of H5N1 HPAIV possesses multiple basic amino acids, as in the sequence RERRRKKR at the cleavage site; however, the role of this motif is not fully understood. Here, we showed that a 33-amino acid long peptide derived from HA of H5N1 HPAIV (HA314-46) has the potential to penetrate various cells and lung tissue through a sialic acid-independent endocytotic pathway. Mutant peptide analyses revealed that the cysteine residue at position 318 and multiple basic amino acids were essential for the cell-penetrating activity. Moreover, reassortant viruses possessing H5 HA could enter sialic acid-deficient cells, and virus internalisation was facilitated by cleavage with recombinant furin. Thus, our findings demonstrate that the HA314-46 motif exhibits cell-penetrating activity through a sialic acid-independent cell entry mechanism.
• Influenza virus infection affects insulin signaling, fatty acid-metabolizing enzyme expressions, and the tricarboxylic acid cycle in mice
  Marumi Ohno; Toshiki Sekiya; Naoki Nomura; Taku ji Daito; Masashi Shingai; Hiroshi Kida
  Scientific Reports, 10, 1, Springer Science and Business Media LLC, Dec. 2020
  Scientific journal
• 2016-2017年のベトナム南部での疫学的研究から明らかになった、鳥インフルエンザウイルスの新たなホットスポットの意義(The implication of a new hot spot of avian influenza based on epidemiological study in southern Vietnam in 2016-2017)
  Le Trung Kien; 磯田 典和; Nguyen Thanh Lam; Chu Duc-Huy; Tien Tien Ngoc; 松野 啓太; 岡松 正敏; 喜田 宏; 迫田 義博; 北海道大人獣共通感染症リサーチセンター/国際協働ユニット
  日本獣医学会学術集会講演要旨集, 163回, 232, 232, (公社)日本獣医学会, Oct. 2020
  English
• Immune profiling of influenza‐specific B‐ and T‐cell responses in macaques using flow cytometry‐based assays
  Marios Koutsakos; Toshiki Sekiya; Brendon Y Chua; Thi Hoang Oanh Nguyen; Adam K Wheatley; Jennifer A Juno; Marumi Ohno; Naoki Nomura; Yuki Ohara; Tomohiro Nishimura; Masafumi Endo; Saori Suzuki; Hirohito Ishigaki; Misako Nakayama; Cong T Nguyen; Yasushi Itoh; Masashi Shingai; Kazumasa Ogasawara; Yoichiro Kino; Stephen J Kent; David C Jackson; Lorena E Brown; Hiroshi Kida; Katherine Kedzierska
  Immunology & Cell Biology, Wiley, 07 Sep. 2020
  Scientific journal
• Genetic and antigenic characterization of H5 and H7 avian influenza viruses isolated from migratory waterfowl in Mongolia from 2017 to 2019.
  Ankhanbaatar Ulaankhuu; Enkhbold Bazarragchaa; Masatoshi Okamatsu; Takahiro Hiono; Khishgee Bodisaikhan; Tsolmon Amartuvshin; Jargalsaikhan Tserenjav; Tsogtbaatar Urangoo; Khanui Buyantogtokh; Keita Matsuno; Takanari Hattori; Tatsunari Kondoh; Masahiro Sato; Yoshihiro Takadate; Shiho Torii; Mao Isono; Kosuke Okuya; Takeshi Saito; Nodoka Kasajima; Yurie Kida; Junki Maruyama; Manabu Igarashi; Ayato Takada; Hiroshi Kida; Damdinjav Batchuluun; Yoshihiro Sakoda
  Virus genes, 56, 4, 472, 479, Aug. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal, The circulation of highly pathogenic avian influenza viruses (HPAIVs) of various subtypes (e.g., H5N1, H5N6, H5N8, and H7N9) in poultry remains a global concern for animal and public health. Migratory waterfowls play important roles in the transmission of these viruses across countries. To monitor virus spread by wild birds, active surveillance for avian influenza in migratory waterfowl was conducted in Mongolia from 2015 to 2019. In total, 5000 fecal samples were collected from lakesides in central Mongolia, and 167 influenza A viruses were isolated. Two H5N3, four H7N3, and two H7N7 viruses were characterized in this study. The amino acid sequence at hemagglutinin (HA) cleavage site of those isolates suggested low pathogenicity in chickens. Phylogenetic analysis revealed that all H5 and H7 viruses were closely related to recent H5 and H7 low pathogenic avian influenza viruses (LPAIVs) isolated from wild birds in Asia and Europe. Antigenicity of H7Nx was similar to those of typical non-pathogenic avian influenza viruses (AIVs). While HPAIVs or A/Anhui/1/2013 (H7N9)-related LPAIVs were not detected in migratory waterfowl in Mongolia, sporadic introductions of AIVs including H5 and H7 viruses into Mongolia through the wild bird migration were identified. Thus, continued monitoring of H5 and H7 AIVs in both domestic and wild birds is needed for the early detection of HPAIVs spread into the country.
• Efficacy of neuraminidase inhibitors against H5N6 highly pathogenic avian influenza virus in a non-human primate model.
  Cong Thanh Nguyen; Saori Suzuki; Yasushi Itoh; Hirohito Ishigaki; Misako Nakayama; Kaori Hayashi; Keita Matsuno; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara
  Antimicrobial agents and chemotherapy, 13 Apr. 2020, [Peer-reviewed], [International Magazine]
  English, Attention has been paid to H5N6 highly pathogenic avian influenza virus (HPAIV) because of its heavy burden on the poultry industry and human mortality. Since an influenza A virus carrying N6 neuraminidase (NA) has never spread in humans, the potential for H5N6 HPAIV to cause disease in humans and the efficacy of antiviral drugs against the virus need to be urgently assessed. We used non-human primates to elucidate the pathogenesis of H5N6 HPAIV as well as to determine the efficacy of antiviral drugs against the virus. H5N6 HPAIV infection led to high fever in cynomolgus macaques. The lung injury caused by the virus was severe with diffuse alveolar damage and neutrophil infiltration. In addition, an increase in IFN-α showed an inverse correlation with virus titers during the infection process. Oseltamivir was effective for reducing H5N6 HPAIV propagation, and continuous treatment with peramivir reduced virus propagation and severity of symptoms in the early stage. This study also showed the pathologically severe lung injury states in the cynomolgus macaques infected with H5N6 HPAIV, even in those that received early antiviral drug treatments, indicating the need for close monitoring and the need for further studies on the virus pathogenicity and new antiviral therapies.
• Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
  Saori Suzuki; Shintaro Shichinohe; Yasushi Itoh; Misako Nakayama; Hirohito Ishigaki; Yuya Mori; Ayako Ogata-Nakahara; Cong Thanh Nguyen; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara
  Antiviral research, 178, 104790, 104790, 06 Apr. 2020, [Peer-reviewed], [International Magazine]
  English, Human cases of H7N9 influenza A virus infection have been increasing since 2013. The first choice of treatment for influenza is neuraminidase (NA) inhibitors (NAIs), but there is a concern that NAI-resistant viruses are selected in the presence of NAIs. In our previous study, an H7N9 virus carrying AA substitution of threonine (T) for isoleucine (I) at residue 222 in NA (NA222T, N2 numbering) and an H7N9 virus carrying AA substitution of lysine (K) for arginine (R) at residue 292 in NA (NA292K, N2 numbering) were found in different macaques that had been infected with A/Anhui/1/2013 (H7N9) and treated with NAIs. In the present study, the variant with NA292K showed not only resistance to NAIs but also lower replication activity in MDCK cells than did the virus with wild-type NA, whereas the variant with NA222T, which was less resistant to NAIs, showed replication activity similar to that of the wild-type virus. Next, we examined the pathogenicity of these H7N9 NAI-resistant viruses in macaques. The variants caused clinical signs similar to those caused by the wild-type virus with similar replication potency. However, the virus with NA292K was replaced within 7 days by that with NA292R (same as the wild-type) in nasal samples from macaques infected with the virus with NA292K, i.e. the so-called revertant (wild-type virus) became dominant in the population in the absence of an NAI. These results suggest that the clinical signs observed in macaques infected with the NA292K virus are caused by the NA292K virus and the NA292R virus and that the virus with NA292K may not replicate continuously in the upper respiratory tract of patients without treatment as effectively as the wild-type virus.
• Genetic and antigenic characterization of the first H7N7 low pathogenic avian influenza viruses isolated in Vietnam.
  Kien Trung Le; Masatoshi Okamatsu; Lam Thanh Nguyen; Keita Matsuno; Duc-Huy Chu; Tien Ngoc Tien; Tung Thanh Le; Hiroshi Kida; Yoshihiro Sakoda
  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 78, 104117, 104117, Mar. 2020, [Peer-reviewed], [International Magazine]
  English, During the annual surveillance of avian influenza viruses (AIVs) in Vietnam in 2018, three H7N7 AIV isolates were identified in domestic ducks in a single flock in Vinh Long province. The present study is the first documented report of H7N7 virus isolates in Vietnam and aimed to characterize these viruses, both genetically and antigenically. Deduced amino acid sequences for the hemagglutinins (HAs) indicated a low pathogenicity of these viruses in chickens. Phylogenetic analysis revealed that the H7 HA genes of these isolates were closely related to each other and belonged to the European-Asian sublineage, together with those of H7N3 viruses isolated from ducks in Cambodia during 2017. They were not genetically related to those of Chinese H7N9 or H7N1 viruses that were previously detected in Vietnam during 2012. Interestingly, the M genes of the two H7N7 virus isolates were phylogenetically classified into distinct groups, suggesting an ongoing reassortment event in domestic ducks because they were isolated from the same flock. These H7N7 viruses exhibited somewhat different antigenic characteristics compared with other representative H7 low pathogenic AIVs. Surprisingly, the antigenicity of Vietnamese H7N7 viruses is similar to Chinese H7N9 highly pathogenic AIV. The findings of this study suggest that H7N7 viruses may be undergoing reassortment and antigenic diversification in poultry flocks in Vietnam. The silent spread of Vietnamese H7N7 viruses in chickens may lead to acquire high pathogenicity in chickens although the zoonotic potential of the viruses seems to be low since these viruses retain typical avian-specific motifs in the receptor-binding site in the HA and there is no mutation related to mammalian adaptation in PB2 gene. Thus, these results highlight the need for continuous and intensive surveillance of avian influenza in Vietnam, targeting not only highly pathogenic AIVs but also low pathogenic viruses.
• A cloned classical swine fever virus derived from the vaccine strain GPE- causes cytopathic effect in CPK-NS cells via type-I interferon-dependent necroptosis.
  Yukari Itakura; Keita Matsuno; Asako Ito; Markus Gerber; Matthias Liniger; Yuri Fujimoto; Tomokazu Tamura; Ken-Ichiro Kameyama; Masatoshi Okamatsu; Nicolas Ruggli; Hiroshi Kida; Yoshihiro Sakoda
  Virus research, 276, 197809, 197809, 15 Jan. 2020, [Peer-reviewed], [International Magazine]
  English, Classical swine fever viruses (CSFVs) do typically not show cytopathic effect (CPE) in cell culture, while some strains such as vaccine strain the GPE- induce CPE in the swine kidney-derived CPK-NS cell line cultured in serum-free medium. These latter strains commonly lack Npro-mediated inhibition of type-I interferon (IFN) induction. In order to explore the molecular mechanisms of GPE--induced CPE, we analyzed the cellular pathways involved. In CPK-NS cells infected with the attenuated-vaccine-derived vGPE- strain, both, apoptosis and necroptosis were induced. Necroptosis was type-I IFN-dependent and critical for visible CPE. In contrast, the parental virulent vALD-A76 strain did not induce any of these pathways nor CPE. We used reverse genetics to investigate which viral factors regulate these cell-death pathways. Interestingly, a mutant vGPE- in which the Npro function was restored to inhibit type-I IFN induction did not induce necroptosis nor CPE but still induced apoptosis, while an Npro-mutant vALD-A76 incapable of inhibiting type-I IFN production induced necroptosis and CPE. Although Erns of CSFV is reportedly involved in controlling apoptosis, apoptosis induction by vGPE- or apoptosis inhibition by vALD-A76 were independent of the unique amino acid difference found in Erns of these two strains. Altogether, these results demonstrate that type-I IFN-dependent necroptosis related to non-functional Npro is the main mechanism for CPE induction by vGPE-, and that viral factor(s) other than Erns may induce or inhibit apoptosis in vGPE- or vALD-A76 infected CPK-NS cells, respectively.
• E190V substitution of H6 hemagglutinin is one of key factors for binding to sulfated sialylated glycan receptor and infection to chickens.
  Yuto Kikutani; Masatoshi Okamatsu; Shoko Nishihara; Sayaka Takase-Yoden; Takahiro Hiono; Robert P de Vries; Ryan McBride; Keita Matsuno; Hiroshi Kida; Yoshihiro Sakoda
  Microbiology and immunology, 14 Jan. 2020, [Peer-reviewed], [International Magazine]
  English, Avian influenza viruses (AIVs) recognize sialic acid linked α2,3 to galactose (SAα2,3Gal) glycans as receptors. In this study, the interactions between hemagglutinins (HAs) of AIVs and sulfated SAα2,3Gal glycans were analyzed to clarify the molecular basis of interspecies transmission of AIVs from ducks to chickens. It was revealed that E190V and N192D substitutions of the HA increased the recovery of viruses derived from an H6 duck virus isolate, A/duck/Hong Kong/960/1980 (H6N2), in chickens. Recombinant HAs from an H6 chicken virus, A/chicken/Tainan/V156/1999 (H6N1), bound to sulfated SAα2,3Gal glycans, whereas the HAs from an H6 duck virus did not. Binding preference of mutant HAs revealed that an E190V substitution is critical for the recognition of sulfated SAα2,3Gal glycans. These results suggest that the binding of the HA from H6 AIVs to sulfated SAα2,3Gal glycans explains a part of mechanisms of interspecies transmission of AIVs from ducks to chickens.
• ベトナムで初単離されたH7N7低病原性鳥インフルエンザウイルスの遺伝学的性状および抗原性の解析(Genetic and antigenic characterization of H7N7 low pathogenic avian influenza viruses firstly isolated in Vietnam)
  Le Trung Kien; Nguyen Thanh Lam; Chu Duc-Huy; Nguyen Tien Ngoc; Nguyen Long Van; Tien Tien Ngoc; 松野 啓太; 岡松 正敏; 喜田 宏; 迫田 義博
  日本獣医学会学術集会講演要旨集, 162回, 392, 392, (公社)日本獣医学会, Aug. 2019
  English
• Cell cytotoxity and anti-glycation activity of taxifolin-rich extract from Japanese larch, Larix kaempferi.
  Muramatsu D; Uchiyama H; Kida H; Iwai A
  Heliyon, 5, 7, e02047, Jul. 2019, [Peer-reviewed]
• A systematic study towards evolutionary and epidemiological dynamics of currently predominant H5 highly pathogenic avian influenza viruses in Vietnam.
  Lam Thanh Nguyen; Simon M Firestone; Mark A Stevenson; Neil D Young; Leslie D Sims; Duc Huy Chu; Tien Ngoc Nguyen; Long Van Nguyen; Tung Thanh Le; Hung Van Nguyen; Hung Nam Nguyen; Tien Ngoc Tien; Tho Dang Nguyen; Bich Ngoc Tran; Keita Matsuno; Masatoshi Okamatsu; Hiroshi Kida; Yoshihiro Sakoda
  Scientific reports, 9, 1, 7723, 7723, 22 May 2019, [Peer-reviewed], [International Magazine]
  English, This study aimed to elucidate virus, host and environmental dynamics of Vietnamese H5 highly pathogenic avian influenza viruses (HPAIVs) during 2014-2017. Epidemiologically, H5 HPAIVs were frequently detected in apparently healthy domestic and Muscovy ducks and therefore these are preferred species for H5 HPAIV detection in active surveillance. Virologically, clade 2.3.2.1c and 2.3.4.4 H5 HPAIVs were predominant and exhibited distinct phylogeographic evolution. Clade 2.3.2.1c viruses clustered phylogenetically in North, Central and South regions, whilst clade 2.3.4.4 viruses only detected in North and Central regions formed small groups. These viruses underwent diverse reassortment with existence of at least 12 genotypes and retained typical avian-specific motifs. These H5 HPAIVs exhibited large antigenic distance from progenitor viruses and commercial vaccines currently used in poultry. Bayesian phylodynamic analysis inferred that clade 2.3.2.1c viruses detected during 2014-2017 were likely descended from homologous clade viruses imported to Vietnam previously and/or preexisting Chinese viruses during 2012-2013. Vietnamese clade 2.3.4.4 viruses closely shared genetic traits with contemporary foreign spillovers, suggesting that there existed multiple transboundary virus dispersals to Vietnam. This study provides insights into the evolution of Vietnamese H5 HPAIVs and highlights the necessity of strengthening control measures such as, preventive surveillance and poultry vaccination.
• Spatiotemporal and risk analysis of H5 highly pathogenic avian influenza in Vietnam, 2014-2017.
  Lam Thanh Nguyen; Mark A Stevenson; Simon M Firestone; Leslie D Sims; Duc Huy Chu; Long Van Nguyen; Tien Ngoc Nguyen; Kien Trung Le; Norikazu Isoda; Keita Matsuno; Masatoshi Okamatsu; Hiroshi Kida; Yoshihiro Sakoda
  Preventive veterinary medicine, 104678, 104678, 22 Apr. 2019, [Peer-reviewed], [International Magazine]
  English, The aim of this study was to describe the spatiotemporal distribution of H5 HPAI outbreak reports for the period 2014-2017 and to identify factors associated with H5 HPAI outbreak reports. Throughout the study period, a total of 139 outbreaks of H5 HPAI in poultry were reported, due to either H5N1 (96 outbreaks) or H5N6 (43 outbreaks) subtype viruses. H5N1 HPAI outbreaks occurred in all areas of Vietnam while H5N6 HPAI outbreaks were only reported in the northern and central provinces. We counted the number of H5N1 and H5N6 outbreak report-positive districts per province over the four-year study period and calculated the provincial-level standardized morbidity ratio for H5N1 and H5N6 outbreak reports as the observed number of positive districts divided by the expected number. A mixed-effects, zero-inflated Poisson regression model was developed to identify risk factors for outbreak reports of each H5N1 and H5N6 subtype virus. Spatially correlated and uncorrelated random effects terms were included in this model to identify areas of the country where outbreak reports occurred after known risk factors had been accounted-for. The presence of an outbreak report in a province in the previous 6-12 months increased the provincial level H5N1 outbreak report risk by a factor of 2.42 (95% Bayesian credible interval [CrI] 1.27-4.60) while 1000 bird increases in the density of chickens decreased provincial level H5N6 outbreak report risk by a factor of 0.65 (95% CrI 0.38 to 0.97). We document distinctly different patterns in the spatial and temporal distribution of H5N1 and H5N6 outbreak reports. Most of the variation in H5N1 report risk was accounted-for by the fixed effects included in the zero-inflated Poisson model. In contrast, the amount of unaccounted-for risk in the H5N6 model was substantially greater than the H5N1 model. For H5N6 we recommend that targeted investigations should be carried out in provinces with relatively large spatially correlated random effect terms to identify likely determinants of disease. Similarly, investigations should be carried out in provinces with relatively low spatially correlated random effect terms to identify protective factors for disease and/or reasons for failure to report.
• Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil.
  Keiichi Taniguchi; Yoshinori Ando; Haruaki Nobori; Shinsuke Toba; Takeshi Noshi; Masanori Kobayashi; Makoto Kawai; Ryu Yoshida; Akihiko Sato; Takao Shishido; Akira Naito; Keita Matsuno; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida
  Scientific reports, 9, 1, 3466, 3466, 05 Mar. 2019, [Peer-reviewed], [International Magazine]
  English, Human infections with avian-origin influenza A(H7N9) virus represent a serious threat to global health; however, treatment options are limited. Here, we show the inhibitory effects of baloxavir acid (BXA) and its prodrug baloxavir marboxil (BXM), a first-in-class cap-dependent endonuclease inhibitor, against A(H7N9), in vitro and in vivo. In cell culture, BXA at four nanomolar concentration achieved a 1.5-2.8 log reduction in virus titers of A(H7N9), including the NA-R292K mutant virus and highly pathogenic avian influenza viruses, whereas NA inhibitors or favipiravir required approximately 20-fold or higher concentrations to achieve the same levels of reduction. A(H7N9)-specific amino acid polymorphism at position 37, implicated in BXA binding to the PA endonuclease domain, did not impact on BXA susceptibility. In mice, oral administration of BXM at 5 and 50 mg/kg twice a day for 5 days completely protected from a lethal A/Anhui/1/2013 (H7N9) challenge, and reduced virus titers more than 2-3 log in the lungs. Furthermore, the potent therapeutic effects of BXM in mice were still observed when a higher virus dose was administered or treatment was delayed up to 48 hours post infection. These findings support further investigation of BXM for A(H7N9) treatment in humans.
• Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 production is ideal for influenza
  Toshiki Sekiya; Edin J Mifsud; Marumi Ohno; Naoki Nomura; Mayumi Sasada; Daisuke Fujikura; Takuji Daito; Masashi Shingai; Yuki Ohara; Tomohiro Nishimura; Masafumi Endo; Ryotarou Mitsumata; Tomio Ikeda; Hironori Hatanaka; Hiroki Kitayama; Kenji Motokawa; Tomoyoshi Sobue; Saori Suzuki; Yasushi Itoh; Lorena E Brown; Kazumasa Ogasawara; Yoichiro Kino; Hiroshi Kida
  Vaccine, 37, 2158, 2166, Mar. 2019, [Peer-reviewed]
  English, Scientific journal
• Evaluation of a rapid isothermal nucleic acid amplification kit, Alere™ i Influenza A&B, for the detection of avian influenza viruses.
  Enkhbold Bazarragchaa; Masatoshi Okamatsu; Ankhanbaatar Ulaankhuu; Augustin Tshibwabwa Twabela; Keita Matsuno; Hiroshi Kida; Yoshihiro Sakoda
  Journal of virological methods, 265, 121, 125, Mar. 2019, [Peer-reviewed], [International Magazine]
  English, Rapid and accurate diagnosis of influenza virus infection is essential for quick responses for both human and animal health. The Alere™ i Influenza A&B is a novel isothermal nucleic acid amplification kit that can detect and differentiate between influenza A and B viruses in human specimens in approximately 15 min. In the present study, the performance of the Alere™ i Influenza A&B kit was evaluated for its ability to detect avian influenza virus in chickens. The kit was able to detect representative avian influenza virus strains (hemagglutinin subtypes H1-H16, including the recently isolated H5 and H7 highly pathogenic avian influenza viruses), and the detection limit of the kit for these viruses varied between 10-1.4-102.1 50% egg-infective dose per test, which is higher than the analytical sensitivity of the antigen detection immunochromatography kit ESPLINE® A INFLUENZA. In experimentally infected chickens inoculated with a highly pathogenic avian influenza virus strain A/chicken/Hokkaido/002/2016 (H5N6), viral RNA was detected in the tracheal and cloacal swabs. These results indicate that this kit has the potential to be used as a rapid screening test of influenza A virus infection in chickens.
• In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
  Takeshi Noshi; Mitsutaka Kitano; Keiichi Taniguchi; Atsuko Yamamoto; Shinya Omoto; Keiko Baba; Takashi Hashimoto; Kayo Ishida; Yukihiro Kushima; Kazunari Hattori; Makoto Kawai; Ryu Yoshida; Masanori Kobayashi; Tomokazu Yoshinaga; Akihiko Sato; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Takao Shishido; Akira Naito
  Antiviral research, 160, 109, 117, Dec. 2018, [Peer-reviewed], [International Magazine]
  English, Cap-dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical "cap-snatching" step of viral RNA transcription, which is considered to be a promising anti-influenza target. Here, we describe in vitro characterization of a novel CEN inhibitor, baloxavir acid (BXA), the active form of baloxavir marboxil (BXM). BXA inhibits viral RNA transcription via selective inhibition of CEN activity in enzymatic assays, and inhibits viral replication in infected cells without cytotoxicity in cytopathic effect assays. The antiviral activity of BXA is also confirmed in yield reduction assays with seasonal type A and B viruses, including neuraminidase inhibitor-resistant strains. Furthermore, BXA shows broad potency against various subtypes of influenza A viruses (H1N2, H5N1, H5N2, H5N6, H7N9 and H9N2). Additionally, serial passages of the viruses in the presence of BXA result in isolation of PA/I38T variants with reduced BXA susceptibility. Phenotypic and genotypic analyses with reverse genetics demonstrate the mechanism of BXA action via CEN inhibition in infected cells. These results reveal the in vitro characteristics of BXA and support clinical use of BXM to treat influenza.
• MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrophage and dendritic cell responses to influenza whole-virus vaccine.
  Okamoto M; Fukushima Y; Kouwaki T; Daito T; Kohara M; Kida H; Oshiumi H
  The Journal of biological chemistry, 293, 48, 18585, 18600, Nov. 2018, [Peer-reviewed]
  Scientific journal
• Repeated detection of H7N9 avian influenza viruses in raw poultry meat illegally brought to Japan by international flight passengers.
  Akihiro Shibata; Masatoshi Okamatsu; Riho Sumiyoshi; Keita Matsuno; Zu-Jyun Wang; Hiroshi Kida; Hiroyuki Osaka; Yoshihiro Sakoda
  Virology, 524, 10, 17, Nov. 2018, [Peer-reviewed], [International Magazine]
  English, H7N9 highly and low pathogenic avian influenza viruses (HPAIV and LPAIV, respectively) have been isolated from duck meat products that were brought illegally into Japan by flight passengers in their hand luggage. These H7N9 virus isolates were phylogenetically closely related to those prevailing in China. Antigenic analysis revealed that the hemagglutinin of the H7N9 HPAIV isolate was slightly different from those of the H7N9 LPAIV and older H7 strains. These meat products contaminated with AIVs repeatedly brought into Japan lead to increased risks of poultry and public health. Continuous border disease control based on the detection and culling of infected poultry and meat products is, thus, essential for the prevention of introduction and spread of AIVs.
• H13 influenza viruses in wild birds have undergone genetic and antigenic diversification in nature.
  Zu-Jyun Wang; Yuto Kikutani; Lam Thanh Nguyen; Takahiro Hiono; Keita Matsuno; Masatoshi Okamatsu; Scott Krauss; Richard Webby; Youn-Jeong Lee; Hiroshi Kida; Yoshihiro Sakoda
  Virus genes, 54, 4, 543, 549, Aug. 2018, [Peer-reviewed], [International Magazine]
  English, Among 16 haemagglutinin (HA) subtypes of avian influenza viruses (AIVs), H13 AIVs have rarely been isolated in wild waterfowl. H13 AIVs cause asymptomatic infection and are maintained mainly in gull and tern populations; however, the recorded antigenic information relating to the viruses has been limited. In this study, 2 H13 AIVs, A/duck/Hokkaido/W345/2012 (H13N2) and A/duck/Hokkaido/WZ68/2012 (H13N2), isolated from the same area in the same year in our surveillance, were genetically and antigenically analyzed with 10 representative H13 strains including a prototype strain, A/gull/Maryland/704/1977 (H13N6). The HA genes of H13 AIVs were phylogenetically divided into 3 groups (I, II, and III). A/duck/Hokkaido/W345/2012 (H13N2) was genetically classified into Group III. This virus was distinct from a prototype strain, A/gull/Maryland/704/1977 (H13N6), and the virus, A/duck/Hokkaido/WZ68/2012 (H13N2), both belonging to Group I. Antigenic analysis indicated that the viruses of Group I were antigenically closely related to those of Group II, but distinct from those of Group III, including A/duck/Hokkaido/W345/2012 (H13N2). In summary, our study indicates that H13 AIVs have undergone antigenic diversification in nature.
• Potency of an inactivated influenza vaccine prepared from A/duck/Mongolia/245/2015 (H10N3) against H10 influenza virus infection in a mouse model
  Suzuki, M; Okamatsu, M; Fujimoto, Y; Hiono, T; Matsuno, K; Kida, H; Sakoda, Y
  Japanese journal of Veterinary Research, 66, 1, 29, 41, Feb. 2018, [Peer-reviewed]
  English, Scientific journal
• Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection
  Daisuke Fujikura; Daisuke Muramatsu; Kochi Toyomane; Satoko Chiba; Takuji Daito; Atsushi Iwai; Takahisa Kouwaki; Masaaki Okamoto; Hideaki Higashi; Hiroshi Kida; Hiroyuki Oshiumi
  Journal of Biochemistry, 163, 1, 31, 38, Oxford University Press, 01 Jan. 2018, [Peer-reviewed]
  English, Scientific journal
• Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression
  Daisuke Muramatsu; Mitsuyasu Okabe; Akinori Takaoka; Hiroshi Kida; Atsushi Iwai
  Scientific Reports, 7, 1, 2831, Nature Publishing Group, 01 Dec. 2017, [Peer-reviewed]
  English, Scientific journal
• A cross-sectional study to quantify the prevalence of avian influenza viruses in poultry at intervention and non-intervention live bird markets in central Vietnam, 2014
  D. -H. Chu; M. A. Stevenson; L. V. Nguyen; N. Isoda; S. M. Firestone; T. N. Nguyen; L. T. Nguyen; K. Matsuno; M. Okamatsu; H. Kida; Y. Sakoda
  TRANSBOUNDARY AND EMERGING DISEASES, 64, 6, 1991, 1999, Dec. 2017, [Peer-reviewed]
  English, Scientific journal
• Selection of antigenic variants of an H5N1 highly pathogenic avian influenza virus in vaccinated chickens
  Lam Thanh Nguyen; Tatsuya Nishi; Shintaro Shichinohe; Duc-Huy Chu; Takahiro Hiono; Keita Matsuno; Masatoshi Okamatsu; Hiroshi Kida; Yoshihiro Sakoda
  VIROLOGY, 510, 252, 261, Oct. 2017, [Peer-reviewed]
  English, Scientific journal
• Efficacy of recombinant measles virus expressing highly pathogenic avian influenza virus (HPAIV) antigen against HPAIV infection in monkeys
  Tomoko Fujiyuki; Ryo Horie; Misako Yoneda; Takeshi Kuraishi; Fumihiko Yasui; Hyun-jeong Kwon; Keisuke Munekata; Fusako Ikeda; Miho Hoshi; Yuri Kiso; Mio Omi; Hiroki Sato; Hiroshi Kida; Shosaku Hattori; Michinori Kohara; Chieko Kai
  SCIENTIFIC REPORTS, 7, 1, 12017, Sep. 2017, [Peer-reviewed]
  English, Scientific journal
• Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild and captive birds in the winter season of 2016-2017 in Northern Japan
  Takahiro Hiono; Masatoshi Okamatsu; Keita Matsuno; Atsushi Haga; Ritsuko Iwata; Lam Thanh Nguyen; Mizuho Suzuki; Yuto Kikutani; Hiroshi Kida; Manabu Onuma; Yoshihiro Sakoda
  MICROBIOLOGY AND IMMUNOLOGY, 61, 9, 387, 397, Sep. 2017, [Peer-reviewed]
  English, Scientific journal
• Rapid and broad detection of H5 hemagglutinin by an immunochromatographic kit using novel monoclonal antibody against highly pathogenic avian influenza virus belonging to the genetic clade 2.3.4.4
  Lam Thanh Nguyen; Kazunari Nakaishi; Keiko Motojima; Ayako Ohkawara; Erina Minato; Junki Maruyama; Takahiro Hiono; Keita Matsuno; Masatoshi Okamatsu; Takashi Kimura; Ayato Takada; Hiroshi Kida; Yoshihiro Sakoda
  PLOS ONE, 12, 8, e0182228, Aug. 2017, [Peer-reviewed]
  English, Scientific journal
• Antigenic diversity of H5 highly pathogenic avian influenza viruses of clade 2.3.4.4 isolated in Asia
  Ayako Ohkawara; Masatoshi Okamatsu; Makoto Ozawa; Duc-Huy Chu; Lam Thanh Nguyen; Takahiro Hiono; Keita Matsuno; Hiroshi Kida; Yoshihiro Sakoda
  MICROBIOLOGY AND IMMUNOLOGY, 61, 5, 149, 158, May 2017, [Peer-reviewed]
  English, Scientific journal
• Potency of whole virus particle and split virion vaccines using dissolving microneedle against challenges of H1N1 and H5N1 influenza viruses in mice
  Akihiro Nakatsukasa; Koji Kuruma; Masatoshi Okamatsu; Takahiro Hiono; Mizuho Suzuki; Keita Matsuno; Hiroshi Kida; Takayoshi Oyamada; Yoshihiro Sakoda
  VACCINE, 35, 21, 2855, 2861, May 2017, [Peer-reviewed]
  English, Scientific journal
• Characterization of Highly Pathogenic Avian Influenza Virus A(H5N6), Japan, November 2016
  Masatoshi Okamatsu; Makoto Ozawa; Kosuke Soda; Hiroki Takakuwa; Atsushi Haga; Takahiro Hiono; Aya Matsuu; Yuko Uchida; Ritsuko Iwata; Keita Matsuno; Masakazu Kuwahara; Toshiyo Yabuta; Tatsufumi Usui; Hiroshi Ito; Manabu Onuma; Yoshihiro Sakoda; Takehiko Saito; Koichi Otsuki; Toshihiro Ito; Hiroshi Kida
  EMERGING INFECTIOUS DISEASES, 23, 4, 691, 695, Apr. 2017, [Peer-reviewed]
  English, Scientific journal
• Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation
  Masanori Kobayashi; Makoto Kodama; Takeshi Noshi; Ryu Yoshida; Takushi Kanazu; Naoki Nomura; Kosuke Soda; Norikazu Isoda; Masatoshi Okamatsu; Yoshihiro Sakoda; Yoshinori Yamano; Akihiko Sato; Hiroshi Kida
  ANTIVIRAL RESEARCH, 139, 41, 48, Mar. 2017, [Peer-reviewed]
  English, Scientific journal
• Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infected with H5N1 highly pathogenic avian influenza virus
  Misako Nakayama; Yasushi Itoh; Shintaro Shichinohe; Rumi Nakabayashi; Hirohito Ishigaki; Yoshihiro Sakoda; Quynh Mai Le; Yoshihiro Kawaoka; Hiroshi Kida; Kazumasa Ogasawara
  VACCINE, 35, 7, 1008, 1017, Feb. 2017, [Peer-reviewed]
  English, Scientific journal
• Vaccination against H9N2 avian influenza virus reduces bronchus-associated lymphoid tissue formation in cynomolgus macaques after intranasal virus challenge infection
  Misako Nakayama; Hiroichi Ozaki; Yasushi Itoh; Kosuke Soda; Hirohito Ishigaki; Masatoshi Okamatsu; Yoshihiro Sakoda; Chun-Ho Park; Hideaki Tsuchiya; Hiroshi Kida; Kazumasa Ogasawara
  PATHOLOGY INTERNATIONAL, 66, 12, 678, 686, Dec. 2016, [Peer-reviewed]
  English, Scientific journal
• Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus
  Fumihiko Yasui; Yasushi Itoh; Ai Ikejiri; Masahiro Kitabatake; Nobuo Sakaguchi; Keisuke Munekata; Shintaro Shichinohe; Yukiko Hayashi; Hirohito Ishigaki; Misako Nakayama; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara; Michinori Kohara
  SCIENTIFIC REPORTS, 6, 37915, Nov. 2016, [Peer-reviewed]
  English, Scientific journal
• Role for migratory wild birds in the global spread of avian influenza H5N8
  Samantha J. Lycett; Rogier Bodewes; Anne Pohlmann; Jill Banks; Krisztian Banyai; Maciej F. Boni; Ruth Bouwstra; Andrew C. Breed; Ian H. Brown; Hualan Chen; Adam Dan; Thomas J. DeLiberto; Nguyen Diep; Marius Gilbert; Sarah Hill; Hon S. Ip; Chang Wen Ke; Hiroshi Kida; Mary Lea Killian; Marion P. Koopmans; Jung-Hoon Kwon; Dong-Hun Lee; Youn Jeong Lee; Lu Lu; Isabella Monne; John Pasick; Oliver G. Pybus; Andrew Rambaut; Timothy P. Robinson; Yoshihiro Sakoda; Siamak Zohari; Chang-Seon Song; David E. Swayne; Mia Kim Torchetti; Hsiang-Jung Tsai; Ron A. M. Fouchier; Martin Beer; Mark Woolhouse; Thijs Kuiken
  SCIENCE, 354, 6309, 213, 217, Oct. 2016, [Peer-reviewed]
  English, Scientific journal
• Recent developments in the diagnosis of avian influenza
  Masatoshi Okamatsu; Takahiro Hiono; Hiroshi Kida; Yoshihiro Sakoda
  VETERINARY JOURNAL, 215, 82, 86, Sep. 2016, [Peer-reviewed]
  English
• Is the optimal pH for membrane fusion in host cells by avian influenza viruses related to host range and pathogenicity?
  Masatoshi Okamatsu; Yurie Motohashi; Takahiro Hiono; Tomokazu Tamura; Kazuki Nagaya; Keita Matsuno; Yoshihiro Sakoda; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 161, 8, 2235, 2242, Aug. 2016, [Peer-reviewed]
  English, Scientific journal
• Genetic and antigenic characterization of H5, H6 and H9 avian influenza viruses circulating in live bird markets with intervention in the center part of Vietnam.
  Chu DH; Okamatsu M; Matsuno K; Hiono T; Ogasawara K; Nguyen LT; Van Nguyen L; Nguyen TN; Nguyen TT; Van Pham D; Nguyen DH; Nguyen TD; To TL; Van Nguyen H; Kida H; Sakoda Y
  Vet Microbiol, 192, 194, 203, Jul. 2016, [Peer-reviewed]
• Cytokine responses to eye spray adjuvants for enhancing vaccine-induced immunity in chickens.
  Hiromi Takaki; Haruko Sato; Riho Kurata; Hirokazu Hikono; Takahiro Hiono; Hiroshi Kida; Misako Matsumoto; Takehiko Saito; Tsukasa Seya
  Microbiology and immunology, 60, 7, 511, 5, Jul. 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Eye spray influenza vaccines for chickens are increasingly available; however, how to enhance cellular and antibody responses to them remains undetermined. Here, eye-drops containing the immune-enhancing adjuvants Pam2CSK4 or polyI:C were assessed in chickens. Application of these TLR agonists to chicken conjunctiva resulted in up-regulation of IL-1β, but not other cytokines, including IFN and IL-6, in the spleen, lung and Harderian gland. Thus, responses to adjuvant applied to the conjunctival mucosa of chickens differ from those expected from the responses to intra-nasal adjuvants in mammals. Identifying an appropriate delivery route for adjuvants is crucial for evoking immune responses in chickens.
• Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense
  Taisho Yamada; Hiromasa Horimoto; Takeshi Kameyama; Sumio Hayakawa; Hiroaki Yamato; Masayoshi Dazai; Ayato Takada; Hiroshi Kida; Debbie Bott; Angela C. Zhou; David Hutin; Tania H. Watts; Masahiro Asaka; Jason Matthews; Akinori Takaoka
  NATURE IMMUNOLOGY, 17, 6, 687, +, Jun. 2016, [Peer-reviewed]
  English, Scientific journal
• Toll-like receptor 9 ligand D-type oligodeoxynucleotide D35 as a broad inhibitor for influenza A virus replication that is associated with suppression of neuraminidase activity
  Hiroshi Yamada; Satoshi Nagase; Kazuo Takahashi; Yoshihiro Sakoda; Hiroshi Kida; Shigefumi Okamoto
  ANTIVIRAL RESEARCH, 129, 81, 92, May 2016, [Peer-reviewed]
  English, Scientific journal
• Comparison of pathogenicities of H7 avian influenza viruses via intranasal and conjunctival inoculation in cynomolgus macaques.
  Shichinohe S; Itoh Y; Nakayama M; Ozaki H; Soda K; Ishigaki H; Okamatsu M; Sakoda Y; Kida H
  Virology, 493, 31, 38, Mar. 2016, [Peer-reviewed]
  Scientific journal
• Amino acid residues at positions 222 and 227 of the hemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to sialyl Lewis X
  Takahiro Hiono; Masatoshi Okamatsu; Manabu Igarashi; Ryan McBride; Robert P. de Vries; Wenjie Peng; James C. Paulson; Yoshihiro Sakoda; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 161, 2, 307, 316, Feb. 2016, [Peer-reviewed]
  English, Scientific journal
• Experimental infection of highly and low pathogenic avian influenza viruses to chicken's, ducks, tree sparrows, jungle crows, and black rats for the evaluation of their roles in virus transmission
  Takahiro Hiono; Masatoshi Okamatsu; Naoki Yamamoto; Kohei Ogasawara; Mayumi Endo; Saya Kuribayashi; Shintaro Shichinohe; Yurie Motohashi; Duc-Huy Chu; Mizuho Suzuki; Takaya Ichikawa; Tatsuya Nishi; Yuri Abe; Keita Matsuno; Kazuyuki Tanaka; Tsutomu Tanigawa; Hiroshi Kida; Yoshihiro Sakoda
  VETERINARY MICROBIOLOGY, 182, 108, 115, Jan. 2016, [Peer-reviewed]
  English, Scientific journal
• Protective efficacy of stockpiled vaccine against H5N8 highly pathogenic avian influenza virus isolated from a chicken in Kumamoto prefecture, Japan, in 2014
  Koichiro Gamoh; Mari Nakamizo; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Shoko Suzuki
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 78, 1, 139, 142, Jan. 2016, [Peer-reviewed]
  English, Scientific journal
• Genetic and antigenic characterization of bovine viral diarrhea viruses isolated from cattle in Hokkaido, Japan
  Yuri Abe; Tomokazu Tamura; Shiho Torii; Shiho Wakamori; Makoto Nagai; Kazuya Mitsuhashi; Junki Mine; Yuri Fujimoto; Naofumi Nagashima; Fumi Yoshino; Yukihiko Sugita; Takushi Nomura; Masatoshi Okamatsu; Hiroshi Kida; Yoshihiro Sakoda
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 78, 1, 61, 70, Jan. 2016, [Peer-reviewed]
  English, Scientific journal
• 豚コレラウイルス非構造蛋白NS4BのN末端領域の機能解析
  田村友和; Nicolas Ruggli; 長島尚史; 岡松正敏; Artur Summerfield; 松野啓太; 喜田宏; 迫田義博
  日本獣医学会学術集会講演要旨集, 158th, Sep. 2015, [Peer-reviewed]
  Japanese, Research society
• Intracellular membrane association of the N-terminal domain of classical swine fever virus NS4B determines viral genome replication and virulence
  Tomokazu Tamura; Nicolas Ruggli; Naofumi Nagashima; Masatoshi Okamatsu; Manabu Igarashi; Junki Mine; Martin A. Hofmann; Matthias Liniger; Artur Summerfield; Hiroshi Kida; Yoshihiro Sakoda
  JOURNAL OF GENERAL VIROLOGY, 96, 9, 2623, 2635, Sep. 2015, [Peer-reviewed]
  English, Scientific journal
• A Single Amino Acid in the M1 Protein Responsible for the Different Pathogenic Potentials of H5N1 Highly Pathogenic Avian Influenza Virus Strains
  Naganori Nao; Masahiro Kajihara; Rashid Manzoor; Junki Maruyama; Reiko Yoshida; Mieko Muramatsu; Hiroko Miyamoto; Manabu Igarashi; Nao Eguchi; Masahiro Sato; Tatsunari Kondoh; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Ayato Takada
  PLOS ONE, 10, 9, e0137989, Sep. 2015, [Peer-reviewed]
  English, Scientific journal
• Genetic and antigenic characterization of H5 and H7 influenza viruses isolated from migratory water birds in Hokkaido, Japan and Mongolia from 2010 to 2014
  Takahiro Hiono; Ayako Ohkawara; Kohei Ogasawara; Masatoshi Okamatsu; Tomokazu Tamura; Duc-Huy Chu; Mizuho Suzuki; Saya Kuribayashi; Shintaro Shichinohe; Ayato Takada; Hirohito Ogawa; Reiko Yoshida; Hiroko Miyamoto; Naganori Nao; Wakako Furuyama; Junki Maruyama; Nao Eguchi; Gerelmaa Ulziibat; Bazarragchaa Enkhbold; Munkhduuren Shatar; Tserenjav Jargalsaikhan; Selenge Byambadorj; Batchuluun Damdinjav; Yoshihiro Sakoda; Hiroshi Kida
  VIRUS GENES, 51, 1, 57, 68, Aug. 2015, [Peer-reviewed]
  English, Scientific journal
• Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates
  Yasushi Itoh; Shintaro Shichinohe; Misako Nakayama; Manabu Igarashi; Akihiro Ishii; Hirohito Ishigaki; Hideaki Ishida; Naoko Kitagawa; Takako Sasamura; Masanori Shiohara; Michiko Doi; Hideaki Tsuchiya; Shinichiro Nakamura; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Kazumasa Ogasawara
  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 59, 8, 4962, 4973, Aug. 2015, [Peer-reviewed]
  English, Scientific journal
• 豚コレラウイルス非構造蛋白NS4Bの機能と病原性に及ぼす影響
  田村友和; Nicolas Ruggli; 長島尚史; 岡松正敏; Artur Summerfield; 松野啓太; 喜田宏; 迫田義博
  Jul. 2015, [Peer-reviewed]
  Japanese, Research society
• The N-terminal domain of N-pro of classical swine fever virus determines its stability and regulates type I IFN production
  Junki Mine; Tomokazu Tamura; Kazuya Mitsuhashi; Masatoshi Okamatsu; Sujira Parchariyanon; Wasana Pinyochon; Nicolas Ruggli; Jon-Duri Tratschin; Hiroshi Kida; Yoshihiro Sakoda
  JOURNAL OF GENERAL VIROLOGY, 96, 1746, 1756, Jul. 2015, [Peer-reviewed]
  English, Scientific journal
• VIRAL GENETIC DETERMINANTS OF CLASSICAL SWINE FEVER VIRUS VIRULENCE
  Tomokazu Tamura; Nicolas Ruggli; Naofumi Nagashima; Masatoshi Okamatsu; Martin A. Hofmann; Hiroshi Kida; Autur Summerfield; Yoshihiro Sakoda
  Jun. 2015, [Peer-reviewed]
  English, International conference proceedings
• Molecular epidemiology of pathogenic Leptospira spp. in the straw-colored fruit bat (Eidolon helvum) migrating to Zambia from the Democratic Republic of Congo
  Hirohito Ogawa; Nobuo Koizumi; Aiko Ohnuma; Alisheke Mutemwa; Bernard M. Hang'ombe; Aaron S. Mweene; Ayato Takada; Chihiro Sugimoto; Yasuhiko Suzuki; Hiroshi Kida; Hirofumi Sawa
  INFECTION GENETICS AND EVOLUTION, 32, 143, 147, Jun. 2015, [Peer-reviewed]
  English, Scientific journal
• Analysis of a pair of END+ and END- viruses derived from the same bovine viral diarrhea virus stock reveals the amino acid determinants in N-pro responsible for inhibition of type I interferon production
  Takashi Kozasa; Yuri Abe; Kazuya Mitsuhashi; Tomokazu Tamura; Hiroshi Aoki; Masatoshi Ishimaru; Shigeyuki Nakamura; Masatoshi Okamatsu; Hiroshi Kida; Yoshihiro Sakoda
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 77, 5, 511, 518, May 2015, [Peer-reviewed]
  English, Scientific journal
• Fluorescent Immunochromatography for Rapid and Sensitive Typing of Seasonal Influenza Viruses
  Akira Sakurai; Katsuyoshi Takayama; Namiko Nomura; Naoki Kajiwara; Masatoshi Okamatsu; Naoki Yamamoto; Tsuruki Tamura; Jitsuho Yamada; Masako Hashimoto; Yoshihiro Sakoda; Yoshihiko Suda; Yukuharu Kobayashi; Hiroshi Kida; Futoshi Shibasaki
  PLOS ONE, 10, 2, e0116715, Feb. 2015, [Peer-reviewed]
  English, Scientific journal
• Mucosal Immunization and Adjuvants
  Hideki Hasegawa; Elly van Reit; Hiroshi Kida
  INFLUENZA PATHOGENESIS AND CONTROL - VOL II, 386, 371, 380, 2015, [Peer-reviewed]
  English, In book
• Multi-colored immunochromatography using nanobeads for rapid and sensitive typing of seasonal influenza viruses
  Akira Sakurai; Katsuyoshi Takayama; Namiko Nomura; Naoki Yamamoto; Yoshihiro Sakoda; Yukuharu Kobayashi; Hiroshi Kida; Futoshi Shibasaki
  JOURNAL OF VIROLOGICAL METHODS, 209, 62, 68, Dec. 2014, [Peer-reviewed]
  English, Scientific journal
• Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza virus library
  Ahmad M. Haredy; Hiroshi Yamada; Yoshihiro Sakoda; Masatoshi Okamatsu; Naoki Yamamoto; Takeshi Omasa; Yasuko Mori; Hiroshi Kida; Shigefumi Okamoto; Yoshinobu Okuno; Koichi Yamanishi
  JOURNAL OF GENERAL VIROLOGY, 95, 2365, 2371, Nov. 2014, [Peer-reviewed]
  English, Scientific journal
• Potency of an inactivated influenza vaccine prepared from A/duck/Hong Kong/960/1980 (H6N2) against a challenge with A/duck/Vietnam/OIE-0033/2012 (H6N2) in mice
  Tatsuya Nishi; Yoshihiro Sakoda; Masatoshi Okamatsu; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 159, 10, 2567, 2574, Oct. 2014, [Peer-reviewed]
  English, Scientific journal
• Humoral Immune Response to Influenza A(H1N1)pdm2009 in Patients with Natural Infection and in Vaccine Recipients in the 2009 Pandemic
  Takuji Kumagai; Tetsuo Nakayama; Yoshinobu Okuno; Tetsuo Kase; Naoko Nishimura; Takao Ozaki; Akiko Miyata; Eitaro Suzuki; Teruo Okafuji; Takao Okafuji; Hitoshi Ochiai; Nobuo Nagata; Hiroyuki Tsutsumi; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Toshiaki Ihara
  VIRAL IMMUNOLOGY, 27, 8, 368, 374, Oct. 2014, [Peer-reviewed]
  English, Scientific journal
• The relationship between in vivo antiviral activity and pharmacokinetic parameters of peramivir in influenza virus infection model in mice
  Makoto Kodama; Ryu Yoshida; Takahiro Hasegawa; Masaaki Izawa; Mitsutaka Kitano; Kaoru Baba; Takeshi Noshi; Takahiro Seki; Kenichi Okazaki; Masakatsu Tsuji; Takushi Kanazu; Hiroshi Kamimori; Tomoyuki Homma; Masanori Kobayashi; Yoshihiro Sakoda; Hiroshi Kida; Akihiko Sato; Yoshinori Yamano
  ANTIVIRAL RESEARCH, 109, 110, 115, Sep. 2014, [Peer-reviewed]
  English, Scientific journal
• Molecular, biological, and antigenic characterization of a Border disease virus isolated from a pig during classical swine fever surveillance in Japan
  Makoto Nagai; Hiroshi Aoki; Yoshihiro Sakoda; Takashi Kozasa; Kaho Tominaga-Teshima; Junki Mine; Yuri Abe; Tomokazu Tamura; Tsubasa Kobayashi; Kaoru Nishine; Kentaro Tateishi; Yudai Suzuki; Mai Fukuhara; Keitaro Ohmori; Reiko Todaka; Kazuhiko Katayama; Tetsuya Mizutani; Shigeyuki Nakamura; Hiroshi Kida; Junsuke Shirai
  JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 26, 4, 547, 552, Jul. 2014, [Peer-reviewed]
  English, Scientific journal
• Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection
  Yasushi Itoh; Reiko Yoshida; Shintaro Shichinohe; Megumi Higuchi; Hirohito Ishigaki; Misako Nakayama; Van Loi Pham; Hideaki Ishida; Mitsutaka Kitano; Masahiko Arikata; Naoko Kitagawa; Yachiyo Mitsuishi; Kazumasa Ogasawara; Hideaki Tsuchiya; Takahiro Hiono; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Mutsumi Ito; Le Quynh Mai; Yoshihiro Kawaoka; Hiroko Miyamoto; Mari Ishijima; Manabu Igarashi; Yasuhiko Suzuki; Ayato Takada
  PLOS PATHOGENS, 10, 6, e1004192, Jun. 2014, [Peer-reviewed]
  English, Scientific journal
• Potency of an inactivated influenza vaccine prepared from A/duck/Mongolia/119/2008 (H7N9) against the challenge with A/Anhui/1/2013 (H7N9)
  Duc-Huy Chu; Yoshihiro Sakoda; Tatsuya Nishi; Takahiro Hiono; Shintaro Shichinohe; Masatoshi Okamatsu; Hiroshi Kida
  VACCINE, 32, 28, 3473, 3479, Jun. 2014, [Peer-reviewed]
  English, Scientific journal
• A chicken influenza virus recognizes fucosylated alpha 2,3 sialoglycan receptors on the epithelial cells lining upper respiratory tracts of chickens
  Takahiro Hiono; Masatoshi Okamatsu; Shoko Nishihara; Sayaka Takase-Yoden; Yoshihiro Sakoda; Hiroshi Kida
  VIROLOGY, 456, 131, 138, May 2014, [Peer-reviewed]
  English, Scientific journal
• N-pro of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites
  Tomokazu Tamura; Naofumi Nagashima; Nicolas Ruggli; Artur Summerfield; Hiroshi Kida; Yoshihiro Sakoda
  VETERINARY RESEARCH, 45, 47, Apr. 2014, [Peer-reviewed]
  English, Scientific journal
• Stimulation with the Aureobasidium pullulans-produced beta-glucan effectively induces interferon stimulated genes in macrophage-like cell lines
  Daisuke Muramatsu; Koji Kawata; Shiho Aoki; Hirofumi Uchiyama; Mitsuyasu Okabe; Tadaaki Miyazaki; Hiroshi Kida; Atsushi Iwai
  SCIENTIFIC REPORTS, 4, 4777, Apr. 2014, [Peer-reviewed]
  English, Scientific journal
• Heat Shock Protein 70 Modulates Influenza A Virus Polymerase Activity
  Rashid Manzoor; Kazumichi Kuroda; Reiko Yoshida; Yoshimi Tsuda; Daisuke Fujikura; Hiroko Miyamoto; Masahiro Kajihara; Hiroshi Kida; Ayato Takada
  JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 11, 7599, 7614, Mar. 2014, [Peer-reviewed]
  English, Scientific journal
• Frequent glycan structure mining of influenza virus data revealed a sulfated glycan motif that increased viral infection
  Tomomi Ichimiya; Shoko Nishihara; Sayaka Takase-Yoden; Hiroshi Kida; Kiyoko Aoki-Kinoshita
  BIOINFORMATICS, 30, 5, 706, 711, Mar. 2014, [Peer-reviewed]
  English, Scientific journal
• Histopathological Evaluation of the Diversity of Cells Susceptible to H5N1 Virulent Avian Influenza Virus
  Haru Ogiwara; Fumihiko Yasui; Keisuke Munekata; Asako Takagi-Kamiya; Tsubasa Munakata; Namiko Nomura; Futoshi Shibasaki; Kazuhiko Kuwahara; Nobuo Sakaguchi; Yoshihiro Sakoda; Hiroshi Kida; Michinori Kohara
  AMERICAN JOURNAL OF PATHOLOGY, 184, 1, 171, 183, Jan. 2014, [Peer-reviewed]
  English, Scientific journal
• Genetic Analysis of an H5N2 Highly Pathogenic Avian Influenza Virus Isolated from a Chicken in a Live Bird Market in Northern Vietnam in 2012
  Tatsuya Nishi; Masatoshi Okamatsu; Kenji Sakurai; Huy Due Chu; Long Pham Thanh; Long van Nguyen; Nam van Hoang; Diep Nguyen Thi; Yoshihiro Sakoda; Hiroshi Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 76, 1, 85, 87, Jan. 2014, [Peer-reviewed]
  English, Scientific journal
• Experimental Infection of Macaques with a Wild Water Bird-Derived Highly Pathogenic Avian Influenza Virus (H5N1)
  Tomoko Fujiyuki; Misako Yoneda; Fumihiko Yasui; Takeshi Kuraishi; Shosaku Hattori; Hyun-jeong Kwon; Keisuke Munekata; Yuri Kiso; Hiroshi Kida; Michinori Kohara; Chieko Kai
  PLOS ONE, 8, 12, e83551, Dec. 2013, [Peer-reviewed]
  English, Scientific journal
• Protection against H5N1 Highly Pathogenic Avian and Pandemic (H1N1) 2009 Influenza Virus Infection in Cynomolgus Monkeys by an Inactivated H5N1 Whole Particle Vaccine
  Misako Nakayama; Shintaro Shichinohe; Yasushi Itoh; Hirohito Ishigaki; Mitsutaka Kitano; Masahiko Arikata; Van Loi Pham; Hideaki Ishida; Naoko Kitagawa; Masatoshi Okamatsu; Yoshihiro Sakoda; Takaya Ichikawa; Hideaki Tsuchiya; Shinichiro Nakamura; Quynh Mai Le; Mutsumi Ito; Yoshihiro Kawaoka; Hiroshi Kida; Kazumasa Ogasawara
  PLOS ONE, 8, 12, e82740, Dec. 2013, [Peer-reviewed]
  English, Scientific journal
• Polymerase complex with lysine at position 627 of the PB2 of influenza virus A/Hong Kong/483/97 (H5N1) efficiently transcribes and replicates virus genes in mouse cells
  Naoki Yamamoto; Yoshihiro Sakoda; Masatoshi Okamatsu; Hiroshi Kida
  VIRUS RESEARCH, 178, 2, 404, 410, Dec. 2013, [Peer-reviewed]
  English, Scientific journal
• Factors responsible for pathogenicity in chickens of a low-pathogenic H7N7 avian influenza virus isolated from a feral duck
  Junki Maruyama; Masatoshi Okamatsu; Kosuke Soda; Yoshihiro Sakoda; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 158, 12, 2473, 2478, Dec. 2013, [Peer-reviewed]
  English, Scientific journal
• Broad-spectrum detection of H5 subtype influenza a viruses with a new fluorescent immunochromatography system
  Akira Sakurai; Katsuyoshi Takayama; Namiko Nomura; Tsubasa Munakata; Naoki Yamamoto; Tsuruki Tamura; Jitsuho Yamada; Masako Hashimoto; Kazuhiko Kuwahara; Yoshihiro Sakoda; Yoshihiko Suda; Yukuharu Kobayashi; Nobuo Sakaguchi; Hiroshi Kida; Michinori Kohara; Futoshi Shibasaki
  PLoS ONE, 8, 11, e76753, 11, 06 Nov. 2013, [Peer-reviewed]
  English, Scientific journal
• Resistance to influenza A virus infection in transformed cell lines expressing an anti-PB2 monoclonal antibody
  Yoshikazu Fujimoto; Kinuyo Ozaki; Masahiro Maeda; Ken-ichi Nishijima; Hiroki Takakuwa; Koichi Otsuki; Hiroshi Kida; Etsuro Ono
  VETERINARY JOURNAL, 198, 2, 487, 493, Nov. 2013, [Peer-reviewed]
  English, Scientific journal
• The genetic and antigenic diversity of avian influenza viruses isolated from domestic ducks, muscovy ducks, and chickens in northern and southern Vietnam, 2010-2012
  Masatoshi Okamatsu; Tatsuya Nishi; Naoki Nomura; Naoki Yamamoto; Yoshihiro Sakoda; Kenji Sakurai; Huy Duc Chu; Long Pham Thanh; Long Van Nguyen; Nam Van Hoang; Tien Ngoc Tien; Reiko Yoshida; Ayato Takada; Hiroshi Kida
  VIRUS GENES, 47, 2, 317, 329, Oct. 2013, [Peer-reviewed]
  English, Scientific journal
• Pathogenicity of Pandemic H1N1 Influenza A Virus in Immunocompromised Cynomolgus Macaques
  Van Loi Pham; Misako Nakayama; Yasushi Itoh; Hirohito Ishigaki; Mitsutaka Kitano; Masahiko Arikata; Hideaki Ishida; Naoko Kitagawa; Shintaro Shichinohe; Masatoshi Okamatsu; Yoshihiro Sakoda; Hideaki Tsuchiya; Shinichiro Nakamura; Hiroshi Kida; Kazumasa Ogasawara
  PLOS ONE, 8, 9, e75910, Sep. 2013, [Peer-reviewed]
  English, Scientific journal
• Selection of H3 avian influenza viruses with SA alpha 2,6Gal receptor specificity in pigs
  Shintaro Shichinohe; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida
  VIROLOGY, 444, 1-2, 404, 408, Sep. 2013, [Peer-reviewed]
  English, Scientific journal
• Characterization of H7N9 influenza A viruses isolated from humans
  Tokiko Watanabe; Maki Kiso; Satoshi Fukuyama; Noriko Nakajima; Masaki Imai; Shinya Yamada; Shin Murakami; Seiya Yamayoshi; Kiyoko Iwatsuki-Horimoto; Yoshihiro Sakoda; Emi Takashita; Ryan McBride; Takeshi Noda; Masato Hatta; Hirotaka Imai; Dongming Zhao; Noriko Kishida; Masayuki Shirakura; Robert P. de Vries; Shintaro Shichinohe; Masatoshi Okamatsu; Tomokazu Tamura; Yuriko Tomita; Naomi Fujimoto; Kazue Goto; Hiroaki Katsura; Eiryo Kawakami; Izumi Ishikawa; Shinji Watanabe; Mutsumi Ito; Yuko Sakai-Tagawa; Yukihiko Sugita; Ryuta Uraki; Reina Yamaji; Amie J. Eisfeld; Gongxun Zhong; Shufang Fan; Jihui Ping; Eileen A. Maher; Anthony Hanson; Yuko Uchida; Takehiko Saito; Makoto Ozawa; Gabriele Neumann; Hiroshi Kida; Takato Odagiri; James C. Paulson; Hideki Hasegawa; Masato Tashiro; Yoshihiro Kawaoka
  NATURE, 501, 7468, 551, +, Sep. 2013, [Peer-reviewed]
  English, Scientific journal
• Excessive Cytokine Response to Rapid Proliferation of Highly Pathogenic Avian Influenza Viruses Leads to Fatal Systemic Capillary Leakage in Chickens
  Saya Kuribayashi; Yoshihiro Sakoda; Takeshi Kawasaki; Tomohisa Tanaka; Naoki Yamamoto; Masatoshi Okamatsu; Norikazu Isoda; Yoshimi Tsuda; Yuji Sunden; Takashi Umemura; Noriko Nakajima; Hideki Hasegawa; Hiroshi Kida
  PLOS ONE, 8, 7, e68375, Jul. 2013, [Peer-reviewed]
  English, Scientific journal
• An MDCK cell culture-derived formalin-inactivated influenza virus whole-virion vaccine from an influenza virus library confers cross-protective immunity by intranasal administration in mice
  Ahmad M. Haredy; Nobuyuki Takenaka; Hiroshi Yamada; Yoshihiro Sakoda; Masatoshi Okamatsu; Naoki Yamamoto; Takeshi Omasa; Hisao Ohtake; Yasuko Mori; Hiroshi Kida; Koichi Yamanishi; Shigefumi Okamoto
  Clinical and Vaccine Immunology, 20, 7, 998, 1007, Jul. 2013, [Peer-reviewed]
  English, Scientific journal
• Proteins of duck influenza virus responsible for acquisition of pathogenicity in chickens
  Naoki Yamamoto; Kosuke Soda; Yoshihiro Sakoda; Masatoshi Okamatsu; Hiroshi Kida
  VIRUS RESEARCH, 173, 2, 294, 298, May 2013, [Peer-reviewed]
  English, Scientific journal
• Potency of an inactivated influenza vaccine prepared from a non-pathogenic H5N1 virus against a challenge with antigenically drifted highly pathogenic avian influenza viruses in chickens
  Shintaro Shichinohe; Masatoshi Okamatsu; Naoki Yamamoto; Yu Noda; Yuka Nomoto; Takashi Honda; Noriyasu Takikawa; Yoshihiro Sakoda; Hiroshi Kida
  VETERINARY MICROBIOLOGY, 164, 1-2, 39, 45, May 2013, [Peer-reviewed]
  English, Scientific journal
• Inhibition of influenza A virus infection by Galectin-9
  T. Hattori; J. Maruyama; Y. Fujioka; Y. Nakayama; Y. Ohba; T. Niki; T. Arikawa; T. Miyazaki; M. Hirashima; H. Kida
  Jpn. J. Vet. Res., 61, 1&2, 5, 18, 北海道大学大学院獣医学研究院, May 2013, [Peer-reviewed]
  English, Scientific journal
• Antiviral activity of stachyflin on influenza A viruses of different hemagglutinin subtypes
  Yurie Motohashi; Manabu Igarashi; Masatoshi Okamatsu; Takeshi Noshi; Yoshihiro Sakoda; Naoki Yamamoto; Kimihito Ito; Ryu Yoshida; Hiroshi Kida
  VIROLOGY JOURNAL, 10, 118, Apr. 2013, [Peer-reviewed]
  English, Scientific journal
• Novel thiosialosides tethered to metal nanoparticles as potent influenza A virus haemagglutinin blockers.
  Feng F; Sakoda Y; Ohyanagi T; Nagahori N; Shibuya H; Okamastu M; Miura N; Kida H; Nishimura SI
  Antiviral therapy, Feb. 2013, [Peer-reviewed]
• The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks
  Masahiro Kajihara; Yoshihiro Sakoda; Kosuke Soda; Kenji Minari; Masatoshi Okamatsu; Ayato Takada; Hiroshi Kida
  VIROLOGY JOURNAL, 10, 45, Feb. 2013, [Peer-reviewed]
  English, Scientific journal
• Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain
  Masatoshi Okamatsu; Yoshihiro Sakoda; Takahiro Hiono; Naoki Yamamoto; Hiroshi Kida
  VIROLOGY JOURNAL, 10, 47, Feb. 2013, [Peer-reviewed]
  English, Scientific journal
• Fluorescence polarization-based assay using N-glycan-conjugated quantum dots for screening in hemagglutinin blockers for influenza A viruses
  Masatoshi Okamatsu; Fei Feng; Tatsuya Ohyanagi; Noriko Nagahori; Kazuhiko Someya; Yoshihiro Sakoda; Nobuaki Miura; Shin-Ichiro Nishimura; Hiroshi Kida
  JOURNAL OF VIROLOGICAL METHODS, 187, 2, 390, 394, Feb. 2013, [Peer-reviewed]
  English, Scientific journal
• Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.
  Toshiyuki Minami; Takashi Kijima; Satoshi Kohmo; Hisashi Arase; Yasushi Otani; Izumi Nagatomo; Ryo Takahashi; Kotaro Miyake; Masayoshi Higashiguchi; Osamu Morimura; Shoichi Ihara; Kazuyuki Tsujino; Haruhiko Hirata; Koji Inoue; Yoshito Takeda; Hiroshi Kida; Isao Tachibana; Atsushi Kumanogoh
  Scientific reports, 3, 2669, 2669, 2013, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Small-cell lung cancer (SCLC) easily recurs with a multidrug resistant phenotype. However, standard therapeutic strategies for relapsed SCLC remain unestablished. We found that human epidermal growth factor receptor 2 (HER2) is not only expressed in pretreated human SCLC specimens, but is also upregulated when HER2-positive SCLC cells acquire chemoresistance. Trastuzumab induced differential levels of antibody-dependent cell-mediated cytotoxicity (ADCC) to HER2-positive SCLC cells. Furthermore, as a mechanism of the differential levels of ADCC, we have revealed that coexpression of intracellular adhesion molecule (ICAM)-1 on SCLC cells is essential to facilitate and accelerate the trastuzumab-mediated ADCC. Although SN-38-resistant SCLC cells lacking ICAM-1 expression were still refractory to trastuzumab, their in vivo growth was significantly suppressed by bevacizumab treatment due to dependence on their distinctive and abundant production of vascular endothelial growth factor. Collectively, stepwise treatment with trastuzumab and bevacizumab is promising for the treatment of chemoresistant SCLC.
• Novel thiosialosides tethered to metal nanoparticles as potent influenza A virus haemagglutinin blockers
  Fei Feng; Yoshihiro Sakoda; Tatsuya Ohyanagi; Noriko Nagahori; Hitomi Shibuya; Masatoshi Okamastu; Nobuaki Miura; Hiroshi Kida; Shin-Ichiro Nishimura
  Antiviral Chemistry and Chemotherapy, 23, 2, 59, 65, 2013, [Peer-reviewed]
  English, Scientific journal
• Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza.
  Fujikura D; Chiba S; Muramatsu D; Kazumata M; Nakayama Y; Kawai T; Akira S; Kida H; Miyazaki T
  PloS one, 8, e55321, 2, 2013, [Peer-reviewed]
• The nucleoprotein is responsible for intracerebral pathogenicity of A/duck/Mongolia/47/2001 (H7N1) in chicks
  Norikazu Isoda; Yoshimi Tsuda; Shingo Asakura; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 157, 12, 2257, 2264, Dec. 2012, [Peer-reviewed]
  English, Scientific journal
• Selection of Classical Swine Fever Virus with Enhanced Pathogenicity Reveals Synergistic Virulence Determinants in E2 and NS4B
  Tomokazu Tamura; Yoshihiro Sakoda; Fumi Yoshino; Takushi Nomura; Naoki Yamamoto; Yuka Sato; Masatoshi Okamatsu; Nicolas Ruggli; Hiroshi Kida
  JOURNAL OF VIROLOGY, 86, 16, 8602, 8613, Aug. 2012, [Peer-reviewed]
  English, Scientific journal
• Development and evaluation of indirect enzyme-linked immunosorbent assay for a screening test to detect antibodies against classical swine fever virus
  Yoshihiro Sakoda; Hiroaki Wakamoto; Tehpin Tamura; Takushi Nomura; Michiko Naito; Hiroshi Aoki; Hiroshi Morita; Hiroshi Kida; Akio Fukusho
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 60, 2-3, 85, 94, Aug. 2012, [Peer-reviewed]
  English, Scientific journal
• Recovery of Leptospires from Miniature Pigs Experimentally Infected with Leptospira interrogans Serovar Manilae Strain UP-MMC under Immunosuppressive Conditions by Dexamethasone
  Yoshihiro Sakoda; Michiko Naito; Mutsumi Ito; Yuki Ito; Norikazu Isoda; Tomohisa Tanaka; Takashi Umemura; Hiroshi Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 74, 7, 955, 958, Jul. 2012, [Peer-reviewed]
  English, Scientific journal
• Purification of human and avian influenza viruses using cellulose sulfate ester (Cellufine Sulfate) in the process of vaccine production
  Yoshihiro Sakoda; Masatoshi Okamatsu; Norikazu Isoda; Naoki Yamamoto; Koichi Ozaki; Yasuto Umeda; Shigeyuki Aoyama; Hiroshi Kida
  MICROBIOLOGY AND IMMUNOLOGY, 56, 7, 490, 495, Jul. 2012, [Peer-reviewed]
  English, Scientific journal
• Memory Immune Responses against Pandemic (H1N1) 2009 Influenza Virus Induced by a Whole Particle Vaccine in Cynomolgus Monkeys Carrying Mafa-A1*052:02
  Masahiko Arikata; Yasushi Itoh; Masatoshi Okamatsu; Toshinaga Maeda; Takashi Shiina; Keiko Tanaka; Shingo Suzuki; Misako Nakayama; Yoshihiro Sakoda; Hirohito Ishigaki; Ayato Takada; Hideaki Ishida; Kosuke Soda; Van Loi Pham; Hideaki Tsuchiya; Shinichiro Nakamura; Ryuzo Torii; Takeshi Shimizu; Hidetoshi Inoko; Iwao Ohkubo; Hiroshi Kida; Kazumasa Ogasawara
  PLOS ONE, 7, 5, e37220, May 2012, [Peer-reviewed]
  English, Scientific journal
• An H9N2 Influenza Virus Vaccine Prepared from a Non-Pathogenic Isolate from a Migratory Duck Confers Protective Immunity in Mice against Challenge with an H9N2 Virus Isolated from a Girl in Hong Kong
  Naoki Nomura; Yoshihiro Sakoda; Kosuke Soda; Masatoshi Okamatsu; Hiroshi Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 74, 4, 441, 447, Apr. 2012, [Peer-reviewed]
  English, Scientific journal
• カモから分離されたH7インフルエンザウイルスのニワトリに対する病原性獲得メカニズム
  丸山 隼輝; 曽田 公輔; 岡松 正敏; 迫田 義博; 喜田 宏
  日本獣医学会学術集会講演要旨集, 153回, 229, 229, (公社)日本獣医学会, Mar. 2012
  Japanese
• Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan
  Yoshihiro Sakoda; Hiroshi Ito; Yuko Uchida; Masatoshi Okamatsu; Naoki Yamamoto; Kosuke Soda; Naoki Nomura; Saya Kuribayashi; Shintaro Shichinohe; Yuji Sunden; Takashi Umemura; Tatsufumi Usui; Hiroichi Ozaki; Tsuyoshi Yamaguchi; Toshiyuki Murase; Toshihiro Ito; Takehiko Saito; Ayato Takada; Hiroshi Kida
  JOURNAL OF GENERAL VIROLOGY, 93, 3, 541, 550, Mar. 2012, [Peer-reviewed]
  English, Scientific journal
• Characterization of avian influenza viruses isolated from domestic ducks in Vietnam in 2009 and 2010
  Naoki Nomura; Yoshihiro Sakoda; Mayumi Endo; Hiromi Yoshida; Naoki Yamamoto; Masatoshi Okamatsu; Kenji Sakurai; Nam Van Hoang; Long Van Nguyen; Huy Duc Chu; Tien Ngoc Tien; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 157, 2, 247, 257, Feb. 2012, [Peer-reviewed]
  English, Scientific journal
• Adaptation of a Duck Influenza A Virus in Quail
  Shinya Yamada; Kyoko Shinya; Ayato Takada; Toshihiro Ito; Takashi Suzuki; Yasuo Suzuki; Quynh Mai Le; Masahito Ebina; Noriyuki Kasai; Hiroshi Kida; Taisuke Horimoto; Pierre Rivailler; Li Mei Chen; Ruben O. Donis; Yoshihiro Kawaoka
  JOURNAL OF VIROLOGY, 86, 3, 1411, 1420, Feb. 2012, [Peer-reviewed]
  English, Scientific journal
• Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population
  Kayoko Sato; Atsushi Iwai; Yosuke Nakayama; Junko Morimoto; Ayato Takada; Mitsuo Maruyama; Hiroshi Kida; Toshimitsu Uede; Tadaaki Miyazaki
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 417, 1, 274, 279, Jan. 2012, [Peer-reviewed]
  English, Scientific journal
• Rapid typing of influenza viruses using super high-speed quantitative real-time PCR
  Akira Sakurai; Namiko Nomura; Reiko Nanba; Takayuki Sinkai; Tsunehito Iwaki; Taminori Obayashi; Kazuhiro Hashimoto; Michiya Hasegawa; Yoshihiro Sakoda; Akihiro Naito; Yoshihito Morizane; Mitsugu Hosaka; Kunio Tsuboi; Hiroshi Kida; Akemi Kai; Futoshi Shibasaki
  JOURNAL OF VIROLOGICAL METHODS, 178, 1-2, 75, 81, Dec. 2011, [Peer-reviewed]
  English, Scientific journal
• Development of a highly sensitive immunochromatographic detection kit for H5 influenza virus hemagglutinin using silver amplification
  Atsuhiko Wada; Yoshihiro Sakoda; Takayoshi Oyamada; Hiroshi Kida
  JOURNAL OF VIROLOGICAL METHODS, 178, 1-2, 82, 86, Dec. 2011, [Peer-reviewed]
  English, Scientific journal
• Phase III Randomized, Double-Blind Study Comparing Single-Dose Intravenous Peramivir with Oral Oseltamivir in Patients with Seasonal Influenza Virus Infection
  Shigeru Kohno; Muh-Yong Yen; Hee-Jin Cheong; Nobuo Hirotsu; Tadashi Ishida; Jun-ichi Kadota; Masashi Mizuguchi; Hiroshi Kida; Jingoro Shimada
  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55, 11, 5267, 5276, Nov. 2011, [Peer-reviewed]
  English, Scientific journal
• Gnarled-Trunk Evolutionary Model of Influenza A Virus Hemagglutinin
  Kimihito Ito; Manabu Igarashi; Yutaka Miyazaki; Teiji Murakami; Syaka Iida; Hiroshi Kida; Ayato Takada
  PLOS ONE, 6, 10, e25953, Oct. 2011, [Peer-reviewed]
  English, Scientific journal
• Antigenic and genetic analysis of H3N8 influenza viruses isolated from horses in Japan and Mongolia, and imported from Canada and Belgium during 2007-2010
  Masayuki Motoshima; Masatoshi Okamatsu; Shingo Asakura; Saya Kuribayashi; Sugar Sengee; Damdinjav Batchuluun; Mika Ito; Yukiko Maeda; Mariko Eto; Yoshihiro Sakoda; Ruuragchaa Sodnomdarjaa; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 156, 8, 1379, 1385, Aug. 2011, [Peer-reviewed]
  English, Scientific journal
• An H5N1 highly pathogenic avian influenza virus that invaded Japan through waterfowl migration
  Masahiro Kajihara; Keita Matsuno; Edgar Simulundu; Mieko Muramatsu; Osamu Noyori; Rashid Manzoor; Eri Nakayama; Manabu Igarashi; Daisuke Tomabechi; Reiko Yoshida; Masatoshi Okamatsu; Yoshihiro Sakoda; Kimihito Ito; Hiroshi Kida; Ayato Takada
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 59, 2-3, 89, 100, Aug. 2011, [Peer-reviewed]
  English, Scientific journal
• Evaluation of the Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) as a Screening Method for the Detection of Influenza Viruses in the Fecal Materials of Water Birds
  Hiromi Yoshida; Yoshihiro Sakoda; Mayumi Endo; Masayuki Motoshima; Fumi Yoshino; Naoki Yamamoto; Masatoshi Okamatsu; Takahiro Soejima; Syouhei Senba; Hidetoshi Kanda; Hiroshi Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 73, 6, 753, 758, Jun. 2011, [Peer-reviewed]
  English, Scientific journal
• A Low Pathogenic H5N2 Influenza Virus Isolated in Taiwan Acquired High Pathogenicity by Consecutive Passages in Chickens
  Kosuke Soda; Ming-Chu Cheng; Hiromi Yoshida; Mayumi Endo; Shu-Hwae Lee; Masatoshi Okamatsu; Yoshihiro Sakoda; Ching-Ho Wang; Hiroshi Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 73, 6, 767, 772, Jun. 2011, [Peer-reviewed]
  English, Scientific journal
• Characterization of influenza A viruses isolated from wild waterfowl in Zambia
  Edgar Simulundu; Akihiro Ishii; Manabu Igarashi; Aaron S. Mweene; Yuka Suzuki; Bernard M. Hang'ombe; Boniface Namangala; Ladslav Moonga; Rashid Manzoor; Kimihito Ito; Ichiro Nakamura; Hirofumi Sawa; Chihiro Sugimoto; Hiroshi Kida; Chuma Simukonda; Wilbroad Chansa; Jack Chulu; Ayato Takada
  JOURNAL OF GENERAL VIROLOGY, 92, 6, 1416, 1427, Jun. 2011, [Peer-reviewed]
  English, Scientific journal
• Intravenous Peramivir for Treatment of Influenza A and B Virus Infection in High-Risk Patients
  Shigeru Kohno; Hiroshi Kida; Masashi Mizuguchi; Nobuo Hirotsu; Tadashi Ishida; Junichi Kadota; Jingoro Shimada
  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55, 6, 2803, 2812, Jun. 2011, [Peer-reviewed]
  English, Scientific journal
• Involvement of Endothelial Apoptosis Underlying Chronic Obstructive Pulmonary Disease-like Phenotype in Adiponectin-null Mice Implications for Therapy
  Kaori Nakanishi; Yoshito Takeda; Satoshi Tetsumoto; Takeo Iwasaki; Kazuyuki Tsujino; Hanako Kuhara; Yingji Jin; Izumi Nagatomo; Hiroshi Kida; Sho Goya; Takashi Kijima; Norikazu Maeda; Tohru Funahashi; Iichiro Shimomura; Isao Tachibana; Ichiro Kawase
  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183, 9, 1164, 1175, May 2011, [Peer-reviewed]
  English, Scientific journal
• Development of a novel rapid immunochromatographic test specific for the H5 influenza virus
  Eiji Miyagawa; Hiroyuki Kogaki; Yoshiaki Uchida; Nobuyuki Fujii; Takashi Shirakawa; Yoshihrio Sakoda; Hiroshi Kida
  JOURNAL OF VIROLOGICAL METHODS, 173, 2, 213, 219, May 2011, [Peer-reviewed]
  English, Scientific journal
• H9N2 influenza virus vaccine prepared from a non-pathogenic isolate from a natural reservoir conferred protective immunity against the challenge with a human H9N2 virus in mice
  Naoki Nomura; Yoshihiro Sakoda; Kosuke Soda; Masatoshi Okamatsu; Hiroshi Kida
  INFLUENZA AND OTHER RESPIRATORY VIRUSES, 5, 363, 366, May 2011, [Peer-reviewed]
  English, Scientific journal
• H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens
  Kosuke Soda; Shingo Asakura; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida
  INFLUENZA AND OTHER RESPIRATORY VIRUSES, 5, 272, 276, May 2011, [Peer-reviewed]
  English, Scientific journal
• Prediction of the antigenic changes of the pandemic (H1N1) 2009 influenza virus hemagglutinin
  Manabu Igarashi; Kimihito Ito; Reiko Yoshida; Daisuke Tomabechi; Hiroshi Kida; Ayato Takada
  INFLUENZA AND OTHER RESPIRATORY VIRUSES, 5, 402, 404, May 2011, [Peer-reviewed]
  English, Scientific journal
• Improvement of the H5N1 influenza virus vaccine strain to decrease the pathogenicity in chicken embryos
  Norikazu Isoda; Yoshihiro Sakoda; Masatoshi Okamatsu; Yoshimi Tsuda; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 156, 4, 557, 563, Apr. 2011, [Peer-reviewed]
  English, Scientific journal
• Requirement for Siva-1 for replication of influenza A virus through apoptosis induction
  Takuya Shiozaki; Atsushi Iwai; Yoshihiro Kawaoka; Ayato Takada; Hiroshi Kida; Tadaaki Miyazaki
  JOURNAL OF GENERAL VIROLOGY, 92, 2, 315, 325, Feb. 2011, [Peer-reviewed]
  English, Scientific journal
• H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens
  Kosuke Soda; Shingo Asakura; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida
  VIROLOGY JOURNAL, 8, 64, Feb. 2011, [Peer-reviewed]
  English, Scientific journal
• Characterization of a non-pathogenic H5N1 influenza virus isolated from a migratory duck flying from Siberia in Hokkaido, Japan, in October 2009
  Naoki Yamamoto; Yoshihiro Sakoda; Masayuki Motoshima; Fumi Yoshino; Kosuke Soda; Masatoshi Okamatsu; Hiroshi Kida
  VIROLOGY JOURNAL, 8, 65, Feb. 2011, [Peer-reviewed]
  English, Scientific journal
• Virological surveillance and phylogenetic analysis of the PB2 genes of influenza viruses isolated from wild water birds flying from their nesting lakes in Siberia to Hokkaido, Japan in autumn
  Rozanah Asmah Abdul Samad; Yoshihiro Sakoda; Yoshimi Tsuda; Edgar Simulundu; Rashid Manzoor; Masatoshi Okamatsu; Kimihito Ito; Hiroshi Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 59, 1, 15, 22, Feb. 2011, [Peer-reviewed]
  English, Scientific journal
• A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus
  Rozanah Asmah Abdul Samad; Naoki Nomura; Yoshimi Tsuda; Rashid Manzoor; Masahiro Kajihara; Daisuke Tomabechi; Takashi Sasaki; Norihide Kokumai; Toshiaki Ohgitani; Masatoshi Okamatsu; Ayato Takada; Yoshihiro Sakoda; Hiroshi Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 59, 1, 23, 29, Feb. 2011, [Peer-reviewed]
  English, Scientific journal
• Detection of highly pathogenic avian influenza virus infection in vaccinated chicken flocks by monitoring antibodies against non-structural protein 1 (NS1)
  Natsumi Takeyama; Kenji Minari; Masahiro Kajihara; Norikazu Isoda; Ryuichi Sakamoto; Takashi Sasaki; Norihide Kokumai; Noriyasu Takikawa; Rikiya Shiraishi; Masaji Mase; Junko Hagiwara; Toshiaki Kodama; Takashi Imamura; Masashi Sakaguchi; Toshiaki Ohgitani; Akira Sawata; Masatoshi Okamatsu; Masatake Muramatsu; Kenji Tsukamoto; Zhifeng Lin; Kotaro Tuchiya; Yoshihiro Sakoda; Hiroshi Kida
  VETERINARY MICROBIOLOGY, 147, 3-4, 283, 291, Jan. 2011, [Peer-reviewed]
  English, Scientific journal
• Genetic characterization and susceptibility on poultry and mammal of H7N6 subtype avian influenza virus isolated in Japan in 2009
  Yuko Uchida; Katsushi Kanehira; Masaji Mase; Nobuhiro Takemae; Chiaki Watanabe; Tatsufumi Usui; Yoshikazu Fujimoto; Toshihiro Ito; Manabu Igarashi; Kimihito Ito; Ayato Takada; Yoshihiro Sakoda; Masatoshi Okamatsu; Yu Yamamoto; Kikuyasu Nakamura; Hiroshi Kida; Yasuaki Hiromoto; Tomoyuki Tsuda; Takehiko Saito
  VETERINARY MICROBIOLOGY, 147, 1-2, 1, 10, Jan. 2011, [Peer-reviewed]
  English, Scientific journal
• Diastereoselective synthesis of the indeno-tetrahydropyridine core bearing a diaryl-substituted stereogenic quaternary carbon center of haouamine B
  Takeshi Tanaka; Hiromi Inui; Hiroshi Kida; Takeshi Kodama; Takuya Okamoto; Aki Takeshima; Yoshimitsu Tachi; Yoshiki Morimoto
  CHEMICAL COMMUNICATIONS, 47, 10, 2949, 2951, 2011, [Peer-reviewed]
  English, Scientific journal
• Antigenic, genetic, and pathogenic characterization of H5N1 highly pathogenic avian influenza viruses isolated from dead whooper swans (Cygnus cygnus) found in northern Japan in 2008
  Masatoshi Okamatsu; Tomohisa Tanaka; Naoki Yamamoto; Yoshihiro Sakoda; Takashi Sasaki; Yoshimi Tsuda; Norikazu Isoda; Norihide Kokumai; Ayato Takada; Takashi Umemura; Hiroshi Kida
  VIRUS GENES, 41, 3, 351, 357, Dec. 2010, [Peer-reviewed]
  English, Scientific journal
• Efficacy and Safety of Intravenous Peramivir for Treatment of Seasonal Influenza Virus Infection
  Shigeru Kohno; Hiroshi Kida; Masashi Mizuguchi; Jingoro Shimada
  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54, 11, 4568, 4574, Nov. 2010, [Peer-reviewed]
  English, Scientific journal
• Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory
  Yoshihiro Sakoda; Sengee Sugar; Damdinjav Batchluun; Tseren-Ochir Erdene-Ochir; Masatoshi Okamatsu; Norikazu Isoda; Kosuke Soda; Hiroki Takakuwa; Yoshimi Tsuda; Naoki Yamamoto; Noriko Kishida; Keita Matsuno; Eri Nakayama; Masahiro Kajihara; Ayaka Yokoyama; Ayato Takada; Ruuragchaa Sodnomdarjaa; Hiroshi Kida
  VIROLOGY, 406, 1, 88, 94, Oct. 2010, [Peer-reviewed]
  English, Scientific journal
• Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon beta Promoter Stimulator 1
  Atsushi Iwai; Takuya Shiozaki; Taro Kawai; Shizuo Akira; Yoshihiro Kawaoka; Ayato Takada; Hiroshi Kida; Tadaaki Miyazaki
  JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 42, 32064, 32074, Oct. 2010, [Peer-reviewed]
  English, Scientific journal
• A Comparison of the Antibody Responses between Specific Pathogen-Free and Commercial Layers Immunized with an Influenza Vaccine Prepared from Inactivated Non-Pathogenic H5N1 Virus by Single Shot
  Takashi Sasaki; Norihide Kokumai; Toshiaki Ohgitani; Takashi Imamura; Akira Sawata; Zhifeng Lin; Yoshihiro Sakoda; Hiroshi Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 72, 6, 819, 821, Jun. 2010, [Peer-reviewed]
  English, Scientific journal
• Novel trivalent anti-influenza reagent
  Fei Feng; Nobuaki Miura; Norikazu Isoda; Yoshihiro Sakoda; Masatoshi Okamatsu; Hiroshi Kida; Shin-Ichiro Nishimura
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20, 12, 3772, 3776, Jun. 2010, [Peer-reviewed]
  English, Scientific journal
• Isolation and Characterization of Potentially Pathogenic H5N2 Influenza Virus from a Chicken in Taiwan in 2008
  Ming-Chu Cheng; Kosuke Soda; Ming-Shiuh Lee; Shu-Hwae Lee; Yoshihiro Sakoda; Hiroshi Kida; Ching-Ho Wang
  AVIAN DISEASES, 54, 2, 885, 893, Jun. 2010, [Peer-reviewed]
  English, Scientific journal
• [Looking back upon the confusion of avian, swine, and pandemic influenza].
  Kida H
  Uirusu, 60, 1, 17, 20, 1, Jun. 2010, [Peer-reviewed]
  Japanese, "Avian influenza", "swine influenza", and "new influenza" are not the names of disease but "influenza" in humans. The preparedness for pandemic influenza should be based on the measures how to control the seasonal influenza that causes thousands of deaths and hundreds of encephalopathy every year in Japan.
• Increase in the Neuraminidase Activity of a Nonpathogenic Newcastle Disease Virus Isolate during Passaging in Chickens
  Ryota Tsunekuni; Hiroshi Ito; Hiroshi Kida; Koichi Otsuki; Toshihiro Ito
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 72, 4, 453, 457, Apr. 2010, [Peer-reviewed]
  English, Scientific journal
• Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants
  Ryota Tsunekuni; Hiroshi Ito; Koichi Otsuki; Hiroshi Kida; Toshihiro Ito
  VIRUS GENES, 40, 2, 252, 255, Apr. 2010, [Peer-reviewed]
  English, Scientific journal
• Lipopolysaccharide treatment and inoculation of influenza A virus results in influenza virus-associated encephalopathy-like changes in neonatal mice
  Tomohisa Tanaka; Yuji Sunden; Yoshihiro Sakoda; Hiroshi Kida; Kenji Ochiai; Takashi Umemura
  JOURNAL OF NEUROVIROLOGY, 16, 2, 125, 132, Apr. 2010, [Peer-reviewed]
  English, Scientific journal
• Amelioration of pneumonia with Streptococcus pneumoniae infection by inoculation with a vaccine against highly pathogenic avian influenza virus in a non-human primate mixed infection model
  Taichiro Miyake; Kosuke Soda; Yasushi Itoh; Yoshihiro Sakoda; Hirohito Ishigaki; Tomoya Nagata; Hideaki Ishida; Misako Nakayama; Hiroichi Ozaki; Hideaki Tsuchiya; Ryuzo Torii; Hiroshi Kida; Kazumasa Ogasawara
  JOURNAL OF MEDICAL PRIMATOLOGY, 39, 1, 58, 70, Feb. 2010, [Peer-reviewed]
  English, Scientific journal
• Subcutaneous inoculation of a whole virus particle vaccine prepared from a non-pathogenic virus library induces protective immunity against H7N7 highly pathogenic avian influenza virus in cynomolgus macaques
  Yasushi Itoh; Hiroichi Ozaki; Hirohito Ishigaki; Yoshihiro Sakoda; Tomoya Nagata; Kosuke Soda; Norikazu Isoda; Taichiro Miyake; Hideaki Ishida; Kiyoko Okamoto; Misako Nakayama; Hideaki Tsuchiya; Ryuzo Torii; Hiroshi Kida; Kazumasa Ogasawara
  VACCINE, 28, 3, 780, 789, Jan. 2010, [Peer-reviewed]
  English, Scientific journal
• Predicting the Antigenic Structure of the Pandemic (H1N1) 2009 Influenza Virus Hemagglutinin
  Manabu Igarashi; Kimihito Ito; Reiko Yoshida; Daisuke Tomabechi; Hiroshi Kida; Ayato Takada
  PLOS ONE, 5, 1, e8553, Jan. 2010, [Peer-reviewed]
  English, Scientific journal
• Intranasal administration of a live non-pathogenic avian H5N1 influenza virus from a virus library confers protective immunity against H5N1 highly pathogenic avian influenza virus infection in mice: Comparison of formulations and administration routes of vaccines
  Yoshitaka Kashima; Mizuho Ikeda; Yasushi Itoh; Yoshihiro Sakoda; Tomoya Nagata; Taichiro Miyake; Kosuke Soda; Hiroichi Ozaki; Misako Nakayama; Hitomi Shibuya; Masatoshi Okamatsu; Hirohito Ishigaki; Hideaki Ishida; Toshihiro Sawai; Yoshihiro Kawaoka; Hiroshi Kida; Kazumasa Ogasawar
  VACCINE, 27, 52, 7402, 7408, Dec. 2009, [Peer-reviewed]
  English, Scientific journal
• Effective Prevention against Rabies by Intracerebral Immunization in Mice
  Jae-Ho Shin; Yoshihiro Sakoda; Shiori Yano; Kenji Ochiai; Hiroshi Kida; Takashi Umemura
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 71, 10, 1331, 1336, Oct. 2009, [Peer-reviewed]
  English, Scientific journal
• Characterization of H3N6 avian influenza virus isolated from a wild white pelican in Zambia
  Edgar Simulundu; Aaron S. Mweene; Daisuke Tomabechi; Bernard M. Hang'ombe; Akihiro Ishii; Yuka Suzuki; Ichiro Nakamura; Hirofumi Sawa; Chihiro Sugimoto; Kimihito Ito; Hiroshi Kida; Lewis Saiwana; Ayato Takada
  ARCHIVES OF VIROLOGY, 154, 9, 1517, 1522, Sep. 2009, [Peer-reviewed]
  English, Scientific journal
• Long lasting immunity in chickens induced by a single shot of influenza vaccine prepared from inactivated non-pathogenic H5N1 virus particles against challenge with a highly pathogenic avian influenza virus
  Takashi Sasaki; Norihide Kokumai; Toshiaki Ohgitani; Ryuichi Sakamoto; Noriyasu Takikawa; Zhifeng Lin; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida
  VACCINE, 27, 38, 5174, 5177, Aug. 2009, [Peer-reviewed]
  English, Scientific journal
• In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
  Yasushi Itoh; Kyoko Shinya; Maki Kiso; Tokiko Watanabe; Yoshihiro Sakoda; Masato Hatta; Yukiko Muramoto; Daisuke Tamura; Yuko Sakai-Tagawa; Takeshi Noda; Saori Sakabe; Masaki Imai; Yasuko Hatta; Shinji Watanabe; Chengjun Li; Shinya Yamada; Ken Fujii; Shin Murakami; Hirotaka Imai; Satoshi Kakugawa; Mutsumi Ito; Ryo Takano; Kiyoko Iwatsuki-Horimoto; Masayuki Shimojima; Taisuke Horimoto; Hideo Goto; Kei Takahashi; Akiko Makino; Hirohito Ishigaki; Misako Nakayama; Masatoshi Okamatsu; Kazuo Takahashi; David Warshauer; Peter A. Shult; Reiko Saito; Hiroshi Suzuki; Yousuke Furuta; Makoto Yamashita; Keiko Mitamura; Kunio Nakano; Morio Nakamura; Rebecca Brockman-Schneider; Hiroshi Mitamura; Masahiko Yamazaki; Norio Sugaya; M. Suresh; Makoto Ozawa; Gabriele Neumann; James Gern; Hiroshi Kida; Kazumasa Ogasawara; Yoshihiro Kawaoka
  NATURE, 460, 7258, 1021, U110, Aug. 2009, [Peer-reviewed]
  English, Scientific journal
• Generation of congenic mouse strains by introducing the virus-resistant genes, Mx1 and Oas1b, of feral mouse-derived inbred strain MSM/Ms into the common strain C57BL/6J
  Kanako Moritoh; Hideto Yamauchi; Atsushi Asano; Kentaro Yoshii; Hiroaki Kariwa; Ikuo Takashima; Norikazu Isoda; Yoshihiro Sakoda; Hiroshi Kida; Nobuya Sasaki; Takashi Agui
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 57, 2, 89, 99, Aug. 2009, [Peer-reviewed]
  English, Scientific journal
• Tetraspanin CD9 Negatively Regulates Lipopolysaccharide-Induced Macrophage Activation and Lung Inflammation
  Mayumi Suzuki; Isao Tachibana; Yoshito Takeda; Ping He; Seigo Minami; Takeo Iwasaki; Hiroshi Kida; Sho Goya; Takashi Kijima; Mitsuhiro Yoshida; Toru Kumagai; Tadashi Osaki; Ichiro Kawase
  JOURNAL OF IMMUNOLOGY, 182, 10, 6485, 6493, May 2009, [Peer-reviewed]
  English, Scientific journal
• Factors responsible for plaque formation of A/duck/Siberia/272/1998 (H13N6) influenza virus on MDCK cells
  Yoshimi Tsuda; Norikazu Isoda; Yoshihiro Sakoda; Hiroshi Kida
  VIRUS RESEARCH, 140, 1-2, 194, 198, Mar. 2009, [Peer-reviewed]
  English, Scientific journal
• Cross-Protective Potential of a Novel Monoclonal Antibody Directed against Antigenic Site B of the Hemagglutinin of Influenza A Viruses
  Reiko Yoshida; Manabu Igarashi; Hiroichi Ozaki; Noriko Kishida; Daisuke Tomabechi; Hiroshi Kida; Kimihito Ito; Ayato Takada
  PLOS PATHOGENS, 5, 3, e1000350, Mar. 2009, [Peer-reviewed]
  English, Scientific journal
• PB2 Protein of a Highly Pathogenic Avian Influenza Virus Strain A/chicken/Yamaguchi/7/2004 (H5N1) Determines Its Replication Potential in Pigs
  Rashid Manzoor; Yoshihiro Sakoda; Naoki Nomura; Yoshimi Tsuda; Hiroichi Ozaki; Masatoshi Okamatsu; Hiroshi Kida
  JOURNAL OF VIROLOGY, 83, 4, 1572, 1578, Feb. 2009, [Peer-reviewed]
  English, Scientific journal
• Evaluation of the potency, optimal antigen level and lasting immunity of inactivated avian influenza vaccine prepared from H5N1 virus
  Takashi Sasaki; Norikazu Isoda; Kosuke Soda; Ryuichi Sakamoto; Kazue Saijo; Junko Hagiwara; Norihide Kokumai; Toshiaki Ohgitani; Takashi Imamura; Akira Sawata; Zhifeng Lin; Yoshihiro Sakoda; Hiroshi Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 56, 4, 189, 198, Feb. 2009, [Peer-reviewed]
  English, Scientific journal
• Antigenic structure of the hemagglutinin of H9N2 influenza viruses
  Masatoshi Okamatsu; Yoshihiro Sakoda; Noriko Kishida; Norikazu Isoda; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 153, 12, 2189, 2195, Dec. 2008, [Peer-reviewed]
  English, Scientific journal
• Structural and Molecular Characterization of the Prefoldin beta Subunit from Thermococcus Strain KS-1
  Hiroshi Kida; Yuri Sugano; Ryo Iizuka; Masahiro Fujihashi; Masafurni Yohda; Kunio Miki
  JOURNAL OF MOLECULAR BIOLOGY, 383, 3, 465, 474, Nov. 2008, [Peer-reviewed]
  English, Scientific journal
• Cross-Glade protective immunity of H5N1 influenza vaccines in a mouse model
  Shin Murakami; Ayaka Iwasa; Kiyoko Iwatsuki-Horimoto; Mutsumi Ito; Maki Kiso; Hiroshi Kida; Ayato Takada; Chairul A. Nidom; Le Quynh Mai; Shinya Yamada; Hirotaka Imai; Yuko Sakai-Tagawa; Yoshihiro Kawaoka; Taisuke Horimoto
  VACCINE, 26, 50, 6398, 6404, Nov. 2008, [Peer-reviewed]
  English, Scientific journal
• Antigenic and genetic analysis of H5 influenza viruses isolated from water birds for the purpose of vaccine use
  Kosuke Soda; Hiroichi Ozaki; Yoshihiro Sakoda; Norikazu Isoda; Yoshinari Haraguchi; Saori Sakabe; Noritaka Kuboki; Noriko Kishida; Ayato Takada; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 153, 11, 2041, 2048, Nov. 2008, [Peer-reviewed]
  English, Scientific journal
• Phylogenic analysis of the M genes of influenza viruses isolated from free-flying water birds from their Northern Territory to Hokkaido, Japan
  Rashid Manzoor; Yoshihiro Sakoda; Aaron Mweene; Yoshimi Tsuda; Noriko Kishida; Gui-Rong Bai; Ken-Ichiro Kameyama; Norikazu Isoda; Kosuke Soda; Michiko Naito; Hiroshi Kida
  VIRUS GENES, 37, 2, 144, 152, Oct. 2008, [Peer-reviewed]
  English, Scientific journal
• Hereditary motor and sensory neuropathy with proximal dominancy in the lower extremities, urinary disturbance, and paroxysmal dry cough
  Shiroh Miura; Hiroki Shibata; Hiroshi Kida; Kazuhito Noda; Katsuro Tomiyasu; Ken Yamamoto; Akiko Iwaki; Mitsuyoshi Ayabe; Hisarnichi Aizawa; Takayuki Taniwaki; Yasuyuki Fukumaki
  JOURNAL OF THE NEUROLOGICAL SCIENCES, 273, 1-2, 88, 92, Oct. 2008, [Peer-reviewed]
  English, Scientific journal
• Phylogenic analysis of the M genes of influenza viruses isolated from free-flying water birds from their Northern Territory to Hokkaido, Japan (Virus Genes DOI: 10.1007/s11262-008-0248-7)
  Rashid Manzoor; Yoshihiro Sakoda; Aaron Mweene; Yoshimi Tsuda; Noriko Kishida; Gui-Rong Bai; Ken-Ichiro Kameyama; Norikazu Isoda; Kosuke Soda; Michiko Naito; Hiroshi Kida
  Virus Genes, 37, 2, 153, Oct. 2008, [Peer-reviewed]
  English, Scientific journal
• Potency of an inactivated avian influenza vaccine prepared from a non-pathogenic H5N1 reassortant virus generated between isolates from migratory ducks in Asia
  Norikazu Isoda; Yoshihiro Sakoda; Noriko Kishida; Kosuke Soda; Saori Sakabe; Ryuichi Sakamoto; Takashi Imamura; Masashi Sakaguchi; Takashi Sasaki; Norihide Kokumai; Toshiaki Ohgitani; Kazue Saijo; Akira Sawata; Junko Hagiwara; Zhifeng Lin; Hiroshi Kida
  ARCHIVES OF VIROLOGY, 153, 9, 1685, 1692, Sep. 2008, [Peer-reviewed]
  English, Scientific journal
• Genetic Analyses of an H3N8 Influenza Virus Isolate, Causative Strain of the Outbreak of Equine Influenza at the Kanazawa Racecourse in Japan in 2007
  Mika Ito; Makoto Nagai; Yuji Hayakawa; Hirofumi Komae; Naruto Murakami; Syouichi Yotsuya; Shingo Asakura; Yoshihiro Sakoda; Hiroshi Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 70, 9, 899, 906, Sep. 2008, [Peer-reviewed]
  English, Scientific journal
• NS1-DIVAシステムを用いた国内製造鳥インフルエンザワクチン注射鶏のモニタリング
  竹山 夏実; 三成 健二; 坂元 隆一; 佐々木 崇; 瀧川 義康; 真瀬 昌司; 土屋 耕太郎; 岡松 正敏; 塚本 健司; 林 志鋒; 迫田 義博; 喜田 宏
  日本獣医学会学術集会講演要旨集, 146回, 193, 193, (公社)日本獣医学会, Sep. 2008
  Japanese
• H2N5 influenza virus isolates from terns in Australia: genetic reassortants between those of the Eurasian and American lineages
  Noriko Kishida; Yoshihiro Sakoda; Mai Shiromoto; Gui-Rong Bai; Norikazu Isoda; Ayato Takada; Graeme Laver; Hiroshi Kida
  VIRUS GENES, 37, 1, 16, 21, Aug. 2008, [Peer-reviewed]
  English, Scientific journal
• Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin
  Manabu Igarashi; Kimihito Ito; Hiroshi Kida; Ayato Takada
  VIROLOGY, 376, 2, 323, 329, Jul. 2008, [Peer-reviewed]
  English, Scientific journal
• Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin
  Toshihiro Sawai; Yasushi Itoh; Hiroichi Ozaki; Norikazu Isoda; Kiyoko Okamoto; Yoshitaka Kashima; Yoshihiro Kawaoka; Yoshihiro Takeuchi; Hiroshi Kida; Kazumasa Ogasawara
  IMMUNOLOGY, 124, 2, 155, 165, Jun. 2008, [Peer-reviewed]
  English, Scientific journal
• Development of a pen-site test kit for the rapid diagnosis of H7 highly pathogenic avian influenza
  Rashid Manzoor; Yoshihiro Sakoda; Saori Sakabe; Tsuyoshi Mochizuki; Yasuharu Namba; Yoshimi Tsuda; Hiroshi Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 70, 6, 557, 562, Jun. 2008, [Peer-reviewed]
  English, Scientific journal
• Cleavage of the NS2-3 protein in the cells of cattle persistently infected with non-cytopathogenic bovine viral diarrhea virus
  Ken-ichiro Kameyama; Yoshihiro Sakoda; Keita Matsuno; Asako Ito; Motoshi Tajima; Shigeyuki Nakamura; Hiroshi Kida
  MICROBIOLOGY AND IMMUNOLOGY, 52, 5, 277, 282, May 2008, [Peer-reviewed]
  English, Scientific journal
• A vaccine prepared from a non-pathogenic H7N7 virus isolated from natural reservoir conferred protective immunity against the challenge with lethal dose of highly pathogenic avian influenza virus in chickens
  Saori Sakabe; Yoshihiro Sakoda; Yoshinari Haraguchi; Norikazu Isoda; Kosuke Soda; Hiroki Takakuwa; Kazue Saijo; Akira Sawata; Katsumi Kume; Junko Hagiwara; Kotaro Tuchiya; Zhifeng Lin; Ryuichi Sakamoto; Takashi Imamura; Takashi Sasaki; Norihide Kokumai; Yoshihiro Kawaoka; Hiroshi Kida
  VACCINE, 26, 17, 2127, 2134, Apr. 2008, [Peer-reviewed]
  English, Scientific journal
• Identification of new genetic subtypes of bovine viral diarrhea virus genotype 1 isolated in Japan
  Makoto Nagai; Michiko Hayashi; Mika Itou; Toyoko Fukutomi; Hiroomi Akashi; Hiroshi Kida; Yoshihiro Sakoda
  VIRUS GENES, 36, 1, 135, 139, Feb. 2008, [Peer-reviewed]
  English, Scientific journal
• Structure and molecular dynamics simulation of archaeal prefoldin: The molecular mechanism for binding and recognition of nonnative substrate proteins
  Akashi Ohtaki; Hiroshi Kida; Yusuke Miyata; Naoki Ide; Akihiro Yonezawa; Takatoshi Arakawa; Ryo Iizuka; Keiichi Noguchi; Akiko Kita; Masafumi Odaka; Kunio Miki; Masafumi Yohda
  JOURNAL OF MOLECULAR BIOLOGY, 376, 4, 1130, 1141, Feb. 2008, [Peer-reviewed]
  English, Scientific journal
• A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques
  Yasushi Itoh; Hiroichi Ozaki; Hideaki Tsuchiya; Kiyoko Okamoto; Ryuzo Torii; Yoshihiro Sakoda; Yoshihiro Kawaoka; Kazumasa Ogasawara; Hiroshi Kida
  Vaccine, 26, 4, 562, 572, 4, 24 Jan. 2008, [Peer-reviewed]
  English, Scientific journal
• Development of vaccine strains of H5 and H7 influenza viruses
  Kosuke Soda; Yoshihiro Sakoda; Norikazu Isoda; Masahiro Kajihara; Yoshinari Haraguchi; Hitomi Shibuya; Hiromi Yoshida; Takashi Sasaki; Ryuichi Sakamoto; Kazue Saijo; Junko Hagiwara; Hiroshi Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 55, 2-3, 93, 98, Jan. 2008, [Peer-reviewed]
  English, Scientific journal
• Carboxyl terminus of the 34 kDa protein of Mycobacterium paratuberculosis shares homologous B-cell epitopes with Mycobacterium avium and Mycobacterium intracellulare.
  Malamo M; Okazaki K; Sakoda Y; Kida H
  The Veterinary record, 161, 853, 857, 25, Dec. 2007, [Peer-reviewed]
• Effect of disinfactnts on infectivity of avian influenza viruses.
  Ito T; Kida H; Otsuki K
  J. Anim. Hyg., 33, 61, 64, Dec. 2007, [Peer-reviewed]
  English, Scientific journal
• The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors.
  Chao-Tan Guo; Noriko Takahashi; Hirokazu Yagi; Koichi Kato; Tadanobu Takahashi; Shuang-Qin Yi; Yong Chen; Toshihiro Ito; Koichi Otsuki; Hiroshi Kida; Yoshihiro Kawaoka; Kazuya I-P Jwa Hidari; Daisei Miyamoto; Takashi Suzuki; Yasuo Suzuki
  Glycobiology, 17, 7, 713, 24, 7, Jul. 2007, [Peer-reviewed], [International Magazine]
  English, The receptor specificity of influenza viruses is one factor that allows avian influenza viruses to cross the species barrier. The recent transmissions of avian H5N1 and H9N2 influenza viruses from chickens and/or quails to humans indicate that avian influenza viruses can directly infect humans without an intermediate host, such as pigs. In this study, we used two strains of influenza A virus (A/PR/8/34, which preferentially binds to an avian-type receptor, and A/Memphis/1/71, which preferentially binds to a human-type receptor) to probe the receptor specificities in host cells. Epithelial cells of both quail and chicken intestines (colons) could bind both avian- and human-type viruses. Infected cultured quail colon cells expressed viral protein and allowed replication of the virus strain A/PR/8/34 or A/Memphis/1/71. To understand the molecular basis of these phenomena, we further investigated the abundance of sialic acid (Sia) linked to galactose (Gal) by the alpha2-3 linkage (Siaalpha2-3Gal) and Siaalpha2-6Gal in host cells. In glycoprotein and glycolipid fractions from quail and chicken colon epithelial cells, there were some bound components of Sia-Gal linkage-specific lectins, Maackia amurensis agglutinin (specific for Siaalpha2-3 Gal) and Sambucus nigra agglutinin (specific for Siaalpha2-6Gal), indicating that both Siaalpha2-3Gal and Siaalpha2-6Gal exist in quail and chicken colon cells. Furthermore, we demonstrated by fluorescence high-performance liquid chromatography (HPLC) analysis that 5-N-acetylneuraminic acid was the main molecular species of Sia, and we demonstrated by multi-dimensional HPLC mapping and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis that bi-antennary complex-type glycans alpha2-6 sialylated at the terminal Gal residue(s) are major (more than 79%) sialyl N-glycans expressed by intestinal epithelial tissues in both the chicken and quail. Taken together, these results indicate that quails and chickens have molecular characterization as potential intermediate hosts for avian influenza virus transmission to humans and could generate new influenza viruses with pandemic potential.
• Genetic and pathobiological characterization of bovine viral diarrhea viruses recently isolated from cattle in Japan
  Keita Matsuno; Yoshihiro Sakoda; Ken-ichiro Kameyama; Kyuzo Tamai; Asako Ito; Hiroshi Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 69, 5, 515, 520, May 2007, [Peer-reviewed]
  English, Scientific journal
• Changes in Cellular Composition and Induction of Cell Death in the Spleen Are Correlated to the Disease Symptoms in Response to Influenza A Virus
  Sato Kayoko; Fujikura Daisuke; Takada Ayato; Kida Hiroshi; Miyazaki Tadaaki
  JOURNAL OF IMMUNOLOGY, 178, 01 Apr. 2007, [Peer-reviewed]
• Serological evidence of influenza A virus infection in Kuril harbor seals (Phoca vitulina stejnegeri) of Hokkaido, Japan
  Kei Fujii; Chiharu Kakumoto; Mari Kobayashi; Sachiko Saito; Tatsuya Kariya; Yukiko Watanabe; Yoshihiro Sakoda; Hiroshi Kida; Masatsugu Suzuki
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 69, 3, 259, 263, Mar. 2007, [Peer-reviewed]
  English, Scientific journal
• Detection of influenza virus hemagglutinin with randomly immobilized anti-hemagglutinin antibody on a carbon nanotube sensor
  Seiji Takeda; Hiroichi Ozaki; Satoshi Hattori; Atsushi Ishii; Hiroshi Kida; Koichi Mukasa
  JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 7, 3, 752, 756, Mar. 2007, [Peer-reviewed]
  English, Scientific journal
• H5N2鳥インフルエンザウイルスを接種したSFP鶏における抗体応答の長期観察と野外感染例の解析
  岡松 正敏; 加茂前 仁弥; 棚橋 美和; 迫田 義博; 真瀬 昌司; 塚本 健司; 喜田 宏; 山口 成夫
  日本獣医学会学術集会講演要旨集, 143回, 195, 195, (公社)日本獣医学会, Mar. 2007
  Japanese
• Extensive accumulation of influenza virus NS1 protein in the nuclei causes effective viral growth in Vero cells
  Hiroichi Ozaki; Hiroshi Kida
  MICROBIOLOGY AND IMMUNOLOGY, 51, 5, 577, 580, 2007, [Peer-reviewed]
  English, Scientific journal
• Serological evidence of leptospiral infection in pig populations in different districts in Japan
  Michiko Naito; Yoshihiro Sakoda; Takayuki Kamikawa; Yoshiki Nitta; Kazuhiko Hirose; Mitsuaki Sakashita; Satoru Kurokawa; Hiroshi Kida
  MICROBIOLOGY AND IMMUNOLOGY, 51, 6, 593, 599, 2007, [Peer-reviewed]
  English, Scientific journal
• Development of an immunochromatographic kit for rapid diagnosis of h5 avian influenza virus infection
  Yoshimi Tsuda; Yoshihiro Sakoda; Saori Sakabe; Tsuyoshi Mochizuki; Yasuharu Namba; Hiroshi Kida
  MICROBIOLOGY AND IMMUNOLOGY, 51, 9, 903, 907, 2007, [Peer-reviewed]
  English, Scientific journal
• Development of an immunochromatographic test kit for rapid detection of bovine viral diarrhea virus antigen.
  Kameyama K; Sakoda Y; Tamai K; Igarashi H; Tajima M; Mochizuki T; Namba Y; Kida H
  Journal of virological methods, 138, 1-2, 140, 146, Dec. 2006, [Peer-reviewed]
• Development of ELISA to detect antibodies specific to Mycobacterium avium subsp paratuberculosis with truncated 34 kDa proteins
  Mumeka Malamo; Yoshihiro Sakoda; Hiroichi Ozaki; Hiroshi Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 54, 2-3, 99, 107, Nov. 2006, [Peer-reviewed]
  English, Scientific journal
• Seroepidemiological survey of morbillivirus infection in Kuril harbor seals (Phoca vitulina stejnegeri) of Hokkaido, Japan
  Kei Fujii; Hiroki Sato; Chiharu Kakumoto; Mari Kobayashi; Sachiko Saito; Tatsuya Kariya; Yukiko Watanabe; Yoshihiro Sakoda; Chieko Kai; Hiroshi Kida; Masatsugu Suzuki
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 54, 2-3, 109, 117, Nov. 2006, [Peer-reviewed]
  English, Scientific journal
• Assembly and budding of Ebolavirus
  Takeshi Noda; Hideki Ebihara; Yukiko Muramoto; Ken Fujii; Ayato Takada; Hiroshi Sagara; Jin Hyun Kim; Hiroshi Kida; Heinz Feldmann; Yoshihiro Kawaoka
  PLOS PATHOGENS, 2, 9, 864, 872, Sep. 2006, [Peer-reviewed]
  English, Scientific journal
• Pathogenicity of H5N1 influenza A viruses isolated in Vietnam between late 2003 and 2005
  Yukiko Muramoto; Thi Quynh Mai Le; Lien Song Phuong; Tung Nguyen; Thu Ha Nguyen; Yuko Sakai-Tagawa; Taisuke Horimoto; Hiroshi Kida; Yoshihiro Kawaoka
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 68, 7, 735, 737, Jul. 2006, [Peer-reviewed]
  English, Scientific journal
• Pathogenicity of a highly pathogenic avian influenza virus, A/chicken/Yamaguchi/7/04 (H5N1) in different species of birds and mammals
  N Isoda; Y Sakoda; N Kishida; GR Bai; K Matsuda; T Umemura; H Kida
  ARCHIVES OF VIROLOGY, 151, 7, 1267, 1279, Jul. 2006, [Peer-reviewed]
  English, Scientific journal
• Rapid detection of avian influenza virus a and subtype H5N1 by single step multiplex reverse transcription-polymerase chain reaction
  HL Wei; GR Bai; AS Mweene; YC Zhou; YL Cong; J Pu; SH Wang; H Kida; JH Liu
  VIRUS GENES, 32, 3, 261, 267, Jun. 2006, [Peer-reviewed]
  English, Scientific journal
• Molecular characterization of the hemagglutinin and neuraminidase genes of H5N1 influenza A viruses isolated from poultry in Vietnam from 2004 to 2005
  Y Muramoto; TQM Le; LS Phuong; T Nguyen; TH Nguyen; Y Sakai-Tagawa; K Iwatsuki-Horimoto; T Horimoto; H Kida; Y Kawaoka
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 68, 5, 527, 531, May 2006, [Peer-reviewed]
  English, Scientific journal
• Disease constraints for utilization of the African buffalo (Syncerus caffer) on game ranches in Zambia
  Hetron M. Munang'andu; Victor M. Siamudaala; Andrew Nambota; John M. Bwalya; Musso Munyeme; Aaron S. Mweene; Ayato Takada; Hiroshi Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 54, 1, 3, 13, May 2006, [Peer-reviewed]
  English
• Ecology and epidemiology of anthrax in cattle and humans in Zambia
  Victor M. Siamudaala; John M. Bwalya; Hetron M. Munang'andu; Peter G. Sinyangwe; Fred Banda; Aaron S. Mweene; Ayato Takada; Hiroshi Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 54, 1, 15, 23, May 2006, [Peer-reviewed]
  English
• Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions
  Y Muramoto; A Takada; K Fujii; T Noda; K Iwatsuki-Horimoto; S Watanabe; T Horimoto; H Kida; Y Kawaoka
  JOURNAL OF VIROLOGY, 80, 5, 2318, 2325, Mar. 2006, [Peer-reviewed]
  English, Scientific journal
• Genetic recombination at different points in the N-pro-coding region of bovine viral diarrhea viruses and the potentials to change their antigenicities and pathogenicities
  K Kameyama; Y Sakoda; K Tamai; M Nagai; H Akashi; H Kida
  VIRUS RESEARCH, 116, 1-2, 78, 84, Mar. 2006, [Peer-reviewed]
  English, Scientific journal
• The amino-terminal residue of glycoprotein B is critical for neutralization of bovine herpesvirus 1
  K Okazaki; S Fujii; A Takada; H Kida
  VIRUS RESEARCH, 115, 2, 105, 111, Feb. 2006, [Peer-reviewed]
  English, Scientific journal
• Highly pathogenic H5N1 influenza virus causes coagulopathy in chickens
  Y Muramoto; H Ozaki; A Takada; CH Park; Y Sunden; T Umemura; Y Kawaoka; H Matsuda; H Kida
  MICROBIOLOGY AND IMMUNOLOGY, 50, 1, 73, 81, 2006, [Peer-reviewed]
  English, Scientific journal
• Architecture of ribonucleoprotein complexes in influenza A virus particles
  T Noda; H Sagara; A Yen; A Takada; H Kida; RH Cheng; Y Kawaoka
  NATURE, 439, 7075, 490, 492, Jan. 2006, [Peer-reviewed]
  English, Scientific journal
• Improvement of a rapid diagnosis kit to detect either influenza a or B virus infections
  GR Bai; Y Sakoda; AS Mweene; N Fujii; H Minakawa; H Kida
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 68, 1, 35, 40, Jan. 2006, [Peer-reviewed]
  English, Scientific journal
• Outbreak of highly pathogenic avian influenza in Japan and anti-influenza virus activity of povidone-iodine products
  H Ito; T Ito; M Hikida; J Yashiro; A Otsuka; H Kida; K Otsuki
  DERMATOLOGY, 212, 115, 118, 2006, [Peer-reviewed]
  English, Scientific journal
• Efficacy of intracerebral immunization against pseudorabies virus in mice
  Jae-Ho Shin; Yoshihiro Sakoda; Jae Hoon Kim; Tomohisa Tanaka; Hiroshi Kida; Takashi Kimura; Kenji Ochiai; Takashi Umemura
  MICROBIOLOGY AND IMMUNOLOGY, 50, 10, 823, 830, 2006, [Peer-reviewed]
  English, Scientific journal
• Serologic investigation of influenza A virus infection in cetaceans from the western North Pacific and the Southern oceans
  K Ohishi; T Maruyama; A Ninomiya; H Kida; R Zenitani; T Bando; Y Fujise; K Nakamatsu; N Miyazaki; AN Boltunov
  MARINE MAMMAL SCIENCE, 22, 1, 214, 221, Jan. 2006, [Peer-reviewed]
  English, Scientific journal
• Library of influenza virus strains for vaccine and diagnostic use against highly pathogenic avian influenza and human pandemics
  H Kida; Y Sakoda
  OIE/FAO International Scientific Conference on Avian Influenza, 124, 69, 72, 2006, [Peer-reviewed]
  English, International conference proceedings
• Efficacy of intracerebral immunization against pseudorabies virus in mice
  Shin JH; Sakoda Y; Kim JH; Tanaka T; Kida H; Kimura T; Ochiai K; Umemura T
  Microbiology and Immunology, 50, 10, 823, 830, 2006, [Peer-reviewed]
  English, Scientific journal
• Serological prevalence of Leptospira interrogans serovar Bratislava in horses in Mongolia
  N Odontsetseg; D Boldbaatar; AS Mweene; H Kida
  VETERINARY RECORD, 157, 17, 518, 519, Oct. 2005, [Peer-reviewed]
  English, Scientific journal
• Effect of endoscopic transthoracic sympathicotomy on plasma natriuretic peptide concentrations in humans
  Y Nakamura; H Yoshizawa; M Hirasawa; H Kida; Y Matsumoto; T Ueyama
  CIRCULATION JOURNAL, 69, 9, 1079, 1083, Sep. 2005, [Peer-reviewed]
  English, Scientific journal
• Application of carbon nanotubes for detecting anti-hemagglutinins based on antigen-antibody interaction
  S Takeda; A Sbagyo; Y Sakoda; A Ishii; M Sawamura; K Sueoka; H Kida; K Mukasa; K Matsumoto
  BIOSENSORS & BIOELECTRONICS, 21, 1, 201, 205, Jul. 2005, [Peer-reviewed]
  English, Scientific journal
• Pathogenicity of H5 influenza viruses for ducks
  N Kishida; Y Sakoda; N Isoda; K Matsuda; M Eto; Y Sunaga; T Umemura; H Kida
  ARCHIVES OF VIROLOGY, 150, 7, 1383, 1392, Jul. 2005, [Peer-reviewed]
  English, Scientific journal
• Serological surveillance of canine leptospirosis in Mongolia
  N Odontsetseg; Y Sakoda; H Kida
  VETERINARY RECORD, 157, 4, 120, 121, Jul. 2005, [Peer-reviewed]
  English, Scientific journal
• In vitro demonstration of neural transmission of avian influenza A virus
  K Matsuda; T Shibata; Y Sakoda; H Kida; T Kimura; K Ochiai; T Umemura
  JOURNAL OF GENERAL VIROLOGY, 86, 4, 1131, 1139, Apr. 2005, [Peer-reviewed]
  English, Scientific journal
• The vagus nerve is one route of transneural invasion for intranasally inoculated influenza A virus in mice
  Matsuda K; Shibata T; Sakoda Y; Kida H; Kimura T; Ochiai K; Umemura T
  Journal of General Virology, 86, 1131, 1139, Apr. 2005, [Peer-reviewed]
  English, Scientific journal
• Nucleocapsid-like structures of Ebola virus reconstructed using electron tomography
  T Noda; K Aoyama; H Sagara; H Kida; Y Kawaoka
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 67, 3, 325, 328, Mar. 2005, [Peer-reviewed]
  English, Scientific journal
• Protective effect of IL-6 on alveolar epithelial cell death induced by hydrogen peroxide
  H Kida; M Yoshida; S Hoshino; K Inoue; Y Yano; M Yanagita; T Kumagai; T Osaki; Tachibana, I; Y Saeki; Kawase, I
  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 288, 2, L342, L349, Feb. 2005, [Peer-reviewed]
  English, Scientific journal
• Viral and bacterial diseases in livestock in Mongolia
  N Odontsetseg; AS Mweene; H Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 52, 4, 151, 162, Feb. 2005, [Peer-reviewed]
  English
• Erratum: Serological evidence of the persistence of infection with Leptospira interrogans serovar hardjo in cattle in Mongolia (Microbiology and Immunology (2005) 49:9 (865-869))
  Namsraijav Odontsetseg; Yoshihiro Sakoda; Hiroshi Kida
  Microbiology and Immunology, 49, 11, 1017, 1018, 2005
  English, Scientific journal
• Serological evidence of the persistence of infection with Leptospira interrogans serovar Hardjo in cattle in Mongolia
  N Odontsetseg; Y Sakoda; H Kida
  MICROBIOLOGY AND IMMUNOLOGY, 49, 9, 865, 869, 2005, [Peer-reviewed]
  English, Scientific journal
• Evaluation of the ESPLINE (R) INFLUENZA A&B-N kit for the diagnosis of avian and swine influenza
  GR Bai; Y Sakoda; AS Mweene; N Kishida; T Yamada; H Minakawa; H Kida
  MICROBIOLOGY AND IMMUNOLOGY, 49, 12, 1063, 1067, 2005, [Peer-reviewed]
  English, Scientific journal
• Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy
  Norihiko Sakai; Takashi Wada; Kengo Furuichi; Yasunori Iwata; Keiichi Yoshimoto; Kiyoki Kitagawa; Satoshi Kokubo; Motoo Kobayashi; Akinori Hara; Junya Yamahana; Toshiya Okumura; Kazuya Takasawa; Shin-Ichi Takeda; Mitsuhiro Yoshimura; Hiroshi Kida; Hitoshi Yokoyama
  American Journal of Kidney Diseases, 45, 1, 54, 65, Jan. 2005, [Peer-reviewed]
  English, Scientific journal
• Genetic conservation of hemagglutinin gene of H9 influenza virus in chicken population in Mainland China
  JH Liu; K Okazaki; A Mweene; WM Shi; QM Wu; JL Su; GZ Zhang; GR Bai; H Kida
  VIRUS GENES, 29, 3, 329, 334, Dec. 2004, [Peer-reviewed]
  English, Scientific journal
• Co-infection of Staphylococcus aureus or Haemophilus paragallinarum exacerbates H9N2 influenza A virus infection in chickens
  N Kishida; Y Sakoda; M Eto; Y Sunaga; H Kida
  ARCHIVES OF VIROLOGY, 149, 11, 2095, 2104, Nov. 2004, [Peer-reviewed]
  English, Scientific journal
• 【高病原性鳥インフルエンザ】インフルエンザウイルスの病原性の分子基盤
  村本 裕紀子; 喜田 宏; 河岡 義裕
  化学療法の領域, 20, 11, 1663, 1667, (株)医薬ジャーナル社, Oct. 2004
  Japanese
• Interregional transmission of the internal protein genes of H2 infoluenza virus in migratory ducks from north America to Eurasia
  JH Liu; K Okazaki; GR Bai; WM Shi; A Mweene; H Kida
  VIRUS GENES, 29, 1, 81, 86, Aug. 2004, [Peer-reviewed]
  English, Scientific journal
• A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication
  K Okazaki; H Kida
  JOURNAL OF GENERAL VIROLOGY, 85, 8, 2131, 2137, Aug. 2004, [Peer-reviewed]
  English, Scientific journal
• [Avian influenza virus].
  Kida H
  Uirusu, 54, 1, 93, 96, 1, Jun. 2004, [Peer-reviewed]
  Japanese, Recent outbreaks of highly pathogenic avian influenza in chickens and ducks that occurred in 9 Asian countries including Japan alarmed to realize that there is no border for infections and gave a rise to great concern for human health as well as for agriculture. This H5N1 virus jumped the species barrier and caused severe disease with high mortality in humans in Viet Nam and Thailand ; 15 deaths of 22 cases and 8 of 12, respectively.A second concern was the possibility that the situation could give rise to another influenza pandemic in humans since genetic reassortment may occur between avian and human influenza viruses when a person is concurrently infected with viruses from both species. This process of gene swapping inside the human body can give rise to a new subtype of the influenza virus to which humans would not have immunity. The outbreaks also emphasized the need to continue active surveillance on avian influenza throughout the year to undertake aggressive emergency control measures as soon as an infection is detected.
• [Round table discussion on highly pathogenic H5N1 avian influenza].
  Nagai Y; Otsuki K; Abe N; Kawaoka Y; Kida H; Kurata T; Sata T; Tashiro M; Yamaguchi N; Yoshikura H
  Uirusu, 54, 123, 141, 1, Jun. 2004, [Peer-reviewed]
• Ｈ５強毒インフルエンザウイルスの神経病原性と解熱剤投与の影響に関する実験的研究
  梅村孝司; 松田一哉; 朴天鍋; 寸田祐嗣; 木村享史; 落合謙爾; 喜田宏
  日本病理学会会誌, 93, 1, 175, Apr. 2004
  Japanese, Scientific journal
• A型インフルエンザウイルスPB2遺伝子分節のパッケージングと粒子形成に必要な領域
  村本 裕紀子; 高田 礼人; 藤井 健; 堀本 研子; 渡辺 真治; 喜田 宏; 河岡 義裕
  日本獣医学会学術集会講演要旨集, 137回, 91, 91, (公社)日本獣医学会, Mar. 2004
  Japanese
• Experimental dual infection of pigs with an H1N1 swine influenza virus (A/Sw/Hok/2/81) and Mycoplasma hyopneumoniae
  S Yazawa; M Okada; M Ono; S Fujii; Y Okuda; Shibata, I; H Kida
  VETERINARY MICROBIOLOGY, 98, 3-4, 221, 228, Mar. 2004, [Peer-reviewed]
  English, Scientific journal
• The vagus nerve is one route of transneural invasion for intranasally inoculated influenza a virus in mice.
  Matsuda K; Park CH; Sunden Y; Kimura T; Ochiai K; Kida H; Umemura T
  Veterinary pathology, 41, 101, 107, 2, Mar. 2004, [Peer-reviewed]
• Antibodies to human-related H3 influenza a virus in Baikal seals (Phoca sibirica) and ringed seals (Phoca hispida) in Russia
  K Ohishi; N Kishida; A Ninomiya; H Kida; Y Takada; N Miyazaki; AN Boltunov; T Maruyama
  MICROBIOLOGY AND IMMUNOLOGY, 48, 11, 905, 909, 2004, [Peer-reviewed]
  English, Scientific journal
• Pathologic findings of initial biopsies reflect the outcomes of membranous nephropathy
  Keiichi Yoshimoto; Hitoshi Yokoyama; Takashi Wada; Kengo Furuichi; Norihiko Sakai; Yasunori Iwata; Satoshi Goshima; Hiroshi Kida
  Kidney International, 65, 1, 148, 153, Blackwell Publishing Inc., 2004, [Peer-reviewed]
  English, Scientific journal
• Induction of interferon-inducible protein-10 and monokine induced by interferon-gamma from human endothelial cells infected with Influenza A virus
  N Ishiguro; A Takada; M Yoshioka; Ma, X; H Kikuta; H Kida; K Kobayashi
  ARCHIVES OF VIROLOGY, 149, 1, 17, 34, Jan. 2004, [Peer-reviewed]
  English, Scientific journal
• Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza virus infection in mice
  A Takada; S Matsushita; A Ninomiya; Y Kawaoka; H Kida
  OPTIONS FOR THE CONTROL OF INFLUENZA V, 1263, 618, 621, 2004, [Peer-reviewed]
  English, International conference proceedings
• Enhancement of pathogenicity of H9N2 influenza A viruses isolated from chicken in China by co-infection with Staphylococcus aureus and Haemophilus paragallinarum
  N Kishida; M Eto; Y Sunaga; H Kida
  OPTIONS FOR THE CONTROL OF INFLUENZA V, 1263, 481, 485, 2004, [Peer-reviewed]
  English, International conference proceedings
• Preparation of a panel of avian influenza viruses of different subtypes for vaccine strains against future pandemics.
  Sakoda Y; Okazaki K; Takada A; Ito Y; Tamai K; Okamatsu M; Ito T; Shortridge KF; Webster RG; Kida H
  Options for the Control of Influenza V, International congress series, 1263, 674, 677, 2004, [Peer-reviewed]
  English, Scientific journal
• Phylogenetic analysis of hemagglutinin and neuraminidase genes of H9N2 viruses isolated from migratory ducks
  JH Liu; K Okazaki; WM Shi; H Kida
  VIRUS GENES, 27, 3, 291, 296, Dec. 2003, [Peer-reviewed]
  English, Scientific journal
• Persistence of viral RNA segments in the central nervous system of mice after recovery from acute influenza A virus infection
  Park CH; Matsuda K; Sunden Y; Ninomiya A; Takada A; Ito H; Kimura T; Ochiai K; Kida H; Umemura T
  Veterinary Microbiology, 97, 259, 268, Dec. 2003, [Peer-reviewed]
  English, Scientific journal
• [Distribution and circulation of influenza viruses in nature].
  Kida H
  Nihon rinsho. Japanese journal of clinical medicine, 61, 1865, 1871, 11, Nov. 2003, [Peer-reviewed]
• The effects of antipyretics on influenza virus encephalitis in mice and chicks
  Y Sunden; CH Park; K Matsuda; A Anagawa; T Kimura; K Ochiai; H Kida; T Umemura
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 65, 11, 1185, 1188, Nov. 2003, [Peer-reviewed]
  English, Scientific journal
• Phylogenetic analysis of neuraminidase gene of H9N2 influenza viruses prevalent in chickens in China during 1995-2002
  JH Liu; K Okazaki; WM Shi; QM Wu; AS Mweene; H Kida
  VIRUS GENES, 27, 2, 197, 202, Oct. 2003, [Peer-reviewed]
  English, Scientific journal
• H9N2 influenza viruses prevalent in poultry in China are phylogenetically distinct from A/quail/Hong Kong/G1/97 presumed to be the donor of the internal protein genes of the H5N1 Hong Kong/97 virus
  JH Liu; K Okazaki; H Ozaki; Y Sakoda; QM Wu; FY Chen; H Kida
  AVIAN PATHOLOGY, 32, 5, 551, 560, Oct. 2003, [Peer-reviewed]
  English, Scientific journal
• Neurotropism of the 1997 Hong Kong H5N1 influenza virus in mice
  H Tanaka; CH Park; A Ninomiya; H Ozaki; A Takada; T Umemura; H Kida
  VETERINARY MICROBIOLOGY, 95, 1-2, 1, 13, Aug. 2003, [Peer-reviewed]
  English, Scientific journal
• Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice
  A Takada; S Matsushita; A Ninomiya; Y Kawaoka; H Kida
  VACCINE, 21, 23, 3212, 3218, Jul. 2003, [Peer-reviewed]
  English, Scientific journal
• [For the prevention and control of pandemic influenza].
  Kida H
  Uirusu, 53, 1, 71, 74, 1, Jun. 2003, [Peer-reviewed]
  Japanese, 1968年に出現した新型香港Aインフルエンザウイルス A/Hong Kong/68 (H3N2) 株は, カモがシベリアの営巣湖沼から家禽 (アヒル) に持ち込んだウイルスと当時ヒトに流行していたH2N2ウイルスが, 中国南部でブタの呼吸器に共感染して生じた遺伝子再集合体である. 1957年の新型H2N2アジアインフルエンザウイルスも同様の経路で出現したものと推定される.1918年に出現して2千万以上の人命を奪ったH1N1スペインインフルエンザウイルスが出現した経路について, これまでに報告された成績から次の考察が導かれる. すなわち, このウイルス株のHAおよびNA遺伝子は, カモがカナダの営巣湖沼から持ち込んだウイルスに起源がある. カモが糞便とともに排泄したウイルスは, 米国の家禽 (シチメンチョウかアヒル) に水系感染し, さらにブタに伝播した. ブタは当時ヒトに流行していたH3N8インフルエンザウイルスにも共感染して, HAおよびNA遺伝子がカモのウイルスに由来する遺伝子再集合体を産生した. これがまずイリノイ州でブタにインフルエンザの流行を起こし, 忽ち米国中西部一帯に広がった. その間にヒトに感染伝播したものがスペインインフルエンザウイルス株である.1997年, 香港で18人に感染して6人を死亡させたニワトリのH5N1ウイルスもまた, シベリアからカモが家禽に持ち込み, ニワトリに受け継がれる間に病原性を獲得したものである. すなわち, 新型ウイルスの遺伝子はすべてカモの腸内ウイルスに由来する. 実際, 家畜, 家禽, 野生鳥獣およびヒトのインフルエンザウイルス遺伝子の系統解析成績は, 全てがカモのウイルスに起源があることを示している.カモはすべてのHA (H1-H15) とNA (N1-N9) 亜型のインフルエンザウイルスを保有する. カモは北方の営巣湖沼でインフルエンザウイルスに水系経口感染し, 結腸陰窩の上皮細胞で増殖したウイルスを糞便と共に湖沼水中に排泄する. 秋になると, カモは南方に渡る. カモが不在の冬期, ウイルスは湖沼水中に凍結保存される. ヒトのウイルスとカモのウイルスがブタに同時感染すると, 両ウイルスの遺伝子再集合体が生ずる. 過去に出現した新型ウイルス遺伝子の導入経路は, 上に述べたように, カモ→アヒル (家禽) →ブタ→ヒトである.1996年秋にシベリアから北海道に飛来したカモから分離した弱毒H5N4ウイルスを不活化して試製したワクチンは, 1997年に香港でニワトリとヒトから分離された強毒H5N1ウイルスに対する力価試験に合格した. また, このワクチンを鼻腔内に滴下したマウスは, 強毒H5N1ウイルスの攻撃に耐過した. すなわち, カモから分離される弱毒ウイルスの中から, 適切な株を予め選定しておけば, 新型ウイルスの出現に際して, 迅速にワクチンを準備できることが判った.以上のように, 新型インフルエンザウイルスはカモの腸内ウイルスが家禽を経て, あるいはさらにブタの呼吸器でヒトのウイルスの遺伝子を獲得した再集合体として出現する. 新型ウイルスの出現に備え, 水禽, その営巣湖沼水, 家禽, ブタとヒトの疫学調査を強化し, 新型ウイルスの出現とその亜型を予測すると共に, 調査で分離されるウイルスの中からワクチン候補株ならびに診断抗原を選出し, 系統保存・供給するグローバルサーベイランス計画"Programme of Excellence for the Control of Pandemic Influenza"を推進している.
• [Report of the 50th annual meeting of the Japanese Society for Virology].
  Kida H
  Uirusu, 53, 1, 93, 94, 1, Jun. 2003, [Peer-reviewed]
  Japanese
• Replication and transmission of influenza viruses in Japanese quail
  NV Makarova; H Ozaki; H Kida; RG Webster; DR Perez
  VIROLOGY, 310, 1, 8, 15, May 2003, [Peer-reviewed]
  English, Scientific journal
• 強毒インフルエンザウイルスは血液凝固不全を引き起こす
  村本 裕紀子; 尾崎 弘一; 高田 礼人; 朴 天鎬; 寸田 祐嗣; 梅村 孝司; 河岡 義裕; 喜田 宏
  日本獣医学会学術集会講演要旨集, 135回, 128, 128, (公社)日本獣医学会, Mar. 2003
  Japanese
• 中国産輸入家きん肉からのニューカッスル病ウイルス及びH9N2亜型インフルエンザウイルスの分離と分離株の性状
  衛藤 真理子; 真瀬 昌司; 岸田 典子; 米川 和宏; 高橋 周子; 喜田 宏; 須永 裕
  日本獣医学会学術集会講演要旨集, 135回, 127, 127, (公社)日本獣医学会, Mar. 2003
  Japanese
• Insertion of cellular sequence and RNA recombination in the structural protein coding region of cytopathogenic bovine viral diarrhoea virus
  M Nagai; Y Sakoda; M Mori; M Hayashi; H Kida; H Akashi
  JOURNAL OF GENERAL VIROLOGY, 84, 2, 447, 452, Feb. 2003, [Peer-reviewed]
  English, Scientific journal
• JC virus strains indigenous to northeastern Siberians and Canadian Inuits are unique but evolutionally related to those distributed throughout Europe and Mediterranean areas
  C Sugimoto; M Hasegawa; HY Zheng; Demenev, V; Y Sekino; K Kojima; T Honjo; H Kida; T Hovi; T Vesikari; JA Schalken; K Tomita; Y Mitsunobu; H Ikegaya; N Kobayashi; T Kitamura; Y Yogo
  JOURNAL OF MOLECULAR EVOLUTION, 55, 3, 322, 335, Sep. 2002, [Peer-reviewed]
  English, Scientific journal
• Generation of velogenic Newcastle disease viruses from a nonpathogenic waterfowl isolate by passaging in chickens
  Y Shengqing; N Kishida; H Ito; H Kida; K Otsuki; Y Kawaoka; T Ito
  VIROLOGY, 301, 2, 206, 211, Sep. 2002, [Peer-reviewed]
  English, Scientific journal
• Seroepidemiological evidence of avian H4, H5, and H9 influenza A virus transmission to pigs in southeastern China
  A Ninomiya; A Takada; K Okazaki; KF Shortridge; H Kida
  VETERINARY MICROBIOLOGY, 88, 2, 107, 114, Aug. 2002, [Peer-reviewed]
  English, Scientific journal
• Intranasal administration of a synthetic peptide vaccine encapsulated in liposome together with an anti-CD40 antibody induces protective immunity against influenza A virus in mice
  A Ninomiya; K Ogasawara; K Kajino; A Takada; H Kida
  VACCINE, 20, 25-26, 3123, 3129, Aug. 2002, [Peer-reviewed]
  English, Scientific journal
• Influenza A virus with defective M2 ion channel activity as a live vaccine
  T Watanabe; S Watanabe; H Kida; Y Kawaoka
  VIROLOGY, 299, 2, 266, 270, Aug. 2002, [Peer-reviewed]
  English, Scientific journal
• The immediate early gene of canine herpesvirus is transcribed through early and late phases
  M Miyoshi; K Okazaki; M Takiguchi; H Kida; A Hashimoto
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 64, 7, 627, 631, Jul. 2002, [Peer-reviewed]
  English, Scientific journal
• The invasion routes of neurovirulent A/Hong Kong/483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice.
  Park CH; Ishinaka M; Takada A; Kida H; Kimura T; Ochiai K; Umemura T
  Archives of virology, 147, 1425, 1436, 7, Jul. 2002, [Peer-reviewed]
• Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP
  T Noda; H Sagara; E Suzuki; A Takada; H Kida; Y Kawaoka
  JOURNAL OF VIROLOGY, 76, 10, 4855, 4865, May 2002, [Peer-reviewed]
  English, Scientific journal
• Polymorphisms and the differential antiviral activity of the chicken Mx gene.
  Ko JH; Jin HK; Asano A; Takada A; Ninomiya A; Kida H; Hokiyama H; Ohara M; Tsuzuki M; Nishibori M; Mizutani M; Watanabe T
  Genome research, 12, 4, 595, 601, 4, Apr. 2002, [Peer-reviewed]
• MLL gene rearrangement in acute myelogenous leukemia after exposure to tegafur/uracil
  Toshihiro Fukushima; Nobuyuki Yoshio; Yutaka Noto; Hiroshi Kida
  International Journal of Hematology, 75, 2, 178, 181, Feb. 2002, [Peer-reviewed]
  English, Scientific journal
• Immunogenicity and protective efficacy of replication-incompetent influenza virus-like particles
  T Watanabe; S Watanabe; G Neumann; H Kida; Y Kawaoka
  JOURNAL OF VIROLOGY, 76, 2, 767, 773, Jan. 2002, [Peer-reviewed]
  English, Scientific journal
• Serological evidence of transmission of human influenza a and B viruses to Caspian seals (Phoca caspica)
  K Ohishi; A Ninomiya; H Kida; CH Park; T Maruyama; T Arai; E Katsumata; T Tobayama; AN Boltunov; LS Khuraskin; N Miyazaki
  MICROBIOLOGY AND IMMUNOLOGY, 46, 9, 639, 644, 2002, [Peer-reviewed]
  English, Scientific journal
• p38 MAPK phosphorylation and NF-κB activation in human crescentic glomerulonephritis
  Norihiko Sakai; Takashi Wada; Kengo Furuichi; Yasunori Iwata; Keiich Yoshimoto; Kiyoki Kitagawa; Satoshi Kokubo; Motoo Kobayashi; Shin-Ichi Takeda; Hiroshi Kida; Ken-Ichi Kobayashi; Naofumi Mukaida; Kouji Matsushima; Hitoshi Yokoyama
  Nephrology Dialysis Transplantation, 17, 6, 998, 1004, 2002, [Peer-reviewed]
  English, Scientific journal
• 新しいインフルエンザワクチンの開発 "半生"ワクチンのレシピ
  渡辺 登喜子; 喜田 宏; 河岡 義裕
  感染・炎症・免疫, 31, 4, 318, 320, 鳥居薬品(株), Dec. 2001, [Peer-reviewed]
  Japanese
• A serological survey of minute virus of canines (MVC; Canine parvovirus type-1) in dogs in the Tokai area of Japan
  A Hashimoto; M Takiguchi; K Hirai; H Kida; LE Carmichael
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 49, 3, 249, 253, Nov. 2001, [Peer-reviewed]
  English, Scientific journal
• Characterization of a human H9N2 influenza virus isolated in Hong Kong
  T Saito; W Lim; T Suzuki; Y Suzuki; H Kida; SI Nishimura; M Tashiro
  VACCINE, 20, 1-2, 125, 133, Oct. 2001, [Peer-reviewed]
  English, Scientific journal
• Detection of antibodies to the nonstructural protein (NS1) of influenza A virus allows distinction between vaccinated and infected horses
  H Ozaki; T Sugiura; S Sugita; H Imagawa; H Kida
  VETERINARY MICROBIOLOGY, 82, 2, 111, 119, Sep. 2001, [Peer-reviewed]
  English, Scientific journal
• Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity.
  Watanabe T; Watanabe S; Ito H; Kida H; Kawaoka Y
  Journal of virology, 75, 12, 5656, 5662, Jun. 2001, [Peer-reviewed]
• Infectivity-enhancing antibodies to Ebola virus glycoprotein.
  Takada Ayato; Watanabe Shinji; Okazaki Katsunori; Kida Hiroshi; Kawaoka Yoshihiro
  Journal of Virology, 75, 5, 2324, 2330, American Society for Microbiology, Mar. 2001
  English, Ebola virus causes severe hemorrhagic fever in primates, resulting in mortality rates of up to 100%, yet there are no satisfactory biologic explanations for this extreme virulence. Here we show that antisera produced by DNA immunization with a plasmid encoding the surface glycoprotein (GP) of the Zaire strain of Ebola virus enhances the infectivity of vesicular stomatitis virus pseudotyped with the GP. Substantially weaker enhancement was observed with antiserum to the GP of the Reston strain, which is much less pathogenic in humans than the Ebola Zaire and Sudan viruses. The enhancing activity was abolished by heat but was increased in the presence of complement system inhibitors, suggesting that heat-labile factors other than the complement system are required for this effect. We also generated an anti-Zaire GP monoclonal antibody that enhanced viral infectivity and another that neutralized it, indicating the presence of distinct epitopes for these properties. Our findings suggest that antibody-dependent enhancement of infectivity may account for the extreme virulence of the virus. They also raise issues about the development of Ebola virus vaccines and the use of passive prophylaxis or therapy with Ebola virus GP antibodies.
• Antigenic variation among equine H3N8 influenza virus hemagglutinins
  H Ozaki; A Shimizu-Nei; S Sugita; T Sugiura; H Imagawa; H Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 48, 4, 177, 186, Feb. 2001, [Peer-reviewed]
  English, Scientific journal
• A rapid and highly sensitive method for diagnosis of equine influenza by antigen detection using immuno-PCR
  H Ozaki; S Sugita; H Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 48, 4, 187, 195, Feb. 2001, [Peer-reviewed]
  English, Scientific journal
• Serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy
  Yasuhiko Tomino; Shigenobu Suzuki; Tomohito Gohda; Michimasa Kobayashi; Satoshi Horikoshi; Hirokazu Imai; Takao Saito; Tetsuya Kawamura; Noriaki Yorioka; Takashi Harada; Yuichiro Yasumoto; Hiroshi Kida; Yutaka Kobayashi; Masayuki Endoh; Hidetoshi Sato; Kensuke Saito
  Journal of Clinical Laboratory Analysis, 15, 1, 25, 29, 2001, [Peer-reviewed]
  English, Scientific journal
• Global surveillance of animal influenza for the control of future pandemics
  H Kida; K Okazaki; A Takada; H Ozaki; M Tashiro; DK Lvov; KF Shortridge; RG Webster
  OPTIONS FOR THE CONTROL OF INFLUENZA IV, 1219, 169, 171, 2001, [Peer-reviewed]
  English, International conference proceedings
• An efficient plasmid-driven system for the generation of influenza virus-like particles for vaccine
  T Watanabe; S Watanabe; G Neumann; H Kida; Y Kawaoka
  OPTIONS FOR THE CONTROL OF INFLUENZA IV, 1219, 1015, 1017, 2001, [Peer-reviewed]
  English, International conference proceedings
• Mucosal vaccination against influenza: protection of pigs immunized with inactivated virus and ether-split vaccine.
  Lim YK; Takada A; Tanizaki T; Ozaki H; Okazaki K; Kida H
  Japanese Journal of Veterinary Research, 48, 197, 203, 2001, [Peer-reviewed]
  English, Scientific journal
• Primary target cells of virulent strains of type A influenza virus in chicken embryos.
  Park CH; Ozaki H; Takada A; Kida H; Ochiai K; Umemura T
  Avian Pathology, 30, 269, 272, 2001, [Peer-reviewed]
  English, Scientific journal
• Sialyl sugar chains as receptors and determinants of host range of influenza A viruses.
  Suzuki Y; Ito T; Suzuki T; Miyamoto D; Kazuya I.-P; J. Hidari; Guo C.-T; Kida H; Webster RG; Chambers TM; Kawaoka Y
  Options for the control of influenza IV, 521, 525, 2001, [Peer-reviewed]
  English, Scientific journal
• Functional importance of the coiled-coil of the Ebola virus glycoprotein.(共著)
  Watanabe Shinji; Takada Ayato; Watanabe Tokiko; Ito Hiroshi; Kida Hiroshi; Kawaoka Yoshihiro
  Journal of Virology, 74, 21, 10194, 10201, American Society for Microbiology, Nov. 2000
  English, Ebola virus contains a single glycoprotein (GP) that is responsible for receptor binding and membrane fusion and is proteolytically cleaved into disulfide-linked GP1 and GP2 subunits. The GP2 subunit possesses a coiled-coil motif, which plays an important role in the oligomerization and fusion activity of other viral GPs. To determine the functional significance of the coiled-coil motif of GP2, we examined the effects of peptides corresponding to the coiled-coil motif of GP2 on the infectivity of a mutant vesicular stomatitis virus (lacking the receptor-binding/fusion protein) pseudotyped with the Ebola virus GP. A peptide corresponding to the C-terminal helix reduced the infectivity of the pseudotyped virus. We next introduced alanine substitutions into hydrophobic residues in the coiled-coil motif to identify residues important for GP function. None of the substitutions affected GP oligomerization, but some mutations, two in the N-terminal helix and all in the C-terminal helix, reduced the ability of GP to confer infectivity to the mutant vesicular stomatitis virus without affecting the transport of GP to the cell surface, its incorporation into virions, and the production of virus particles. These results indicate that the coiled-coil motif of GP2 plays an important role in facilitating the entry of Ebola virus into host cells and that peptides corresponding to this region could act as efficient antiviral agents.
• Isolation of Pseudomonas aeruginosa from Ushubetsu River water in Hokkaido, Japan
  Yoh Aoi; Hidehiko Nakata; Hiroshi Kida
  Japanese Journal of Veterinary Research, 48, 1, 29, 34, May 2000, [Peer-reviewed]
  English, Scientific journal
• Influenza virus-induced encephalopathy: Clinicopathologic study of an autopsied case
  Mitsuo Takahashi; Tatsuo Yamada; Yoshio Nakashita; Hiroaki Saikusa; Masatune Deguchi; Hiroshi Kida; Masato Tashiro; Tetsuya Toyoda
  Pediatrics International, 42, 2, 204, 214, 2000, [Peer-reviewed]
  English, Scientific journal
• Hypothermia with acute renal failure in a patient suffering from diabetic nephropathy and malnutrition
  M. Yokoyama; Y. Noto; H. Kida
  Diabetes and Metabolism, 26, 2, 145, 147, 2000, [Peer-reviewed]
  English, Scientific journal
• Distinct expression of CCR1 and CCR5 in glomerular and interstitial lesions of human glomerular diseases
  Kengo Furuichi; Takashi Wada; Norihiko Sakai; Yasunori Iwata; Keiichi Yoshimoto; Miho Shimizu; Ken-Ichi Kobayashi; Kazuya Takasawa; Hiroshi Kida; Shin-Ichi Takeda; Naofumi Mukaida; Kouji Matsushima; Hitoshi Yokoyama
  American Journal of Nephrology, 20, 4, 291, 299, S. Karger AG, 2000, [Peer-reviewed]
  English, Scientific journal
• Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy
  Takashi Wada; Kengo Furuichi; Norihiko Sakai; Yasunori Iwata; Keiichi Yoshimoto; Miho Shimizu; Shin-Ichi Takeda; Kazuya Takasawa; Mitsuhiro Yoshimura; Hiroshi Kida; Ken-Ichi Kobayashi; Naofumi Mukaida; Takero Naito; Kouji Matsushima; Hitoshi Yokoyama
  Kidney International, 58, 4, 1492, 1499, 2000, [Peer-reviewed]
  English, Scientific journal
• Epitope mapping of the influenza A virus RNA polymerase PA using monoclonal antibodies
  M Hatta; Y Asano; K Masunaga; T Ito; K Okazaki; T Toyoda; E Kawaoka; A Ishihama; H Kida
  ARCHIVES OF VIROLOGY, 145, 5, 957, 964, 2000, [Peer-reviewed]
  English, Scientific journal
• Structure of the infected cell protein 0 gene of canine herpesvirus.
  Miyoshi M; Takiguchi M; Yasuda J; Hashimoto A; Takada A; Okazaki K; Kida H
  Archives of Virology, 145, 8, 1715, 1723, 2000, [Peer-reviewed]
  English, Scientific journal
• Downregulation of  1 integrins by Ebola virus glycoprotein: Implication for virus entry.
  Takada A; Watanabe S; Ito H; Okazaki K; Kida H; Kawaoka Y
  Virology, 278, 1, 20, 26, 2000, [Peer-reviewed]
  English, Scientific journal
• Mapping of functional domains on the influenza A virus RNA polymerase PB2 molecule using monoclonal antibodies
  Hatta M; Asano Y; Masunaga K; Ito T; Okazaki K; Toyoda T; Kawaoka Y; Ishihama A; Kida H
  Arch. Virol., 145, 9, 1947, 1961, 2000, [Peer-reviewed]
  English, Scientific journal
• Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve
  Sinya K; Shimada A; Ito T; Umemura T; Tanaka H; Takada A; Kida H; Morita T; Otsuki K
  Arch. Virol., 145, 1, 187, 195, 2000, [Peer-reviewed]
  English, Scientific journal
• Epitope mapping of the influenza A virus RNA polymerase PA using monoclonal antibodies.
  Hatta M; Asano Y; Masunaga K; Ito T; Okazaki K; Toyoda T; Kawaoka Y; Ishihama A; Kida H
  Arch. Virol., 145, 5, 895, 903, 2000, [Peer-reviewed]
  English, Scientific journal
• Precursor genes of future pandemic influenza viruses are perpetuated in ducks nesting in Siberia.
  Okazaki K; Takada A; Ito T; Imai M; Takakuwa H; Hatta M; Ozaki H; Tanizaki T; Nagano T; Ninomiya A; Demenev VA; Tyaptirganov MM; Yamnikova SS; Lvov DK; Kida H
  Arch.Virol., 145, 5, 885, 893, 2000, [Peer-reviewed]
  English, Scientific journal
• Recognition of N-glycolyneuraminic acid linked to galactose by α2,3 linkage associated with intestinal replication of influenza A virus in ducks
  Ito T; Suzuki Y; Suzuki T; Takada A; Horimoto T; Wells K; Kida H; Otsuki K; Kawaoka Y
  J. Virol., 74, 19, 9300, 9305, 2000, [Peer-reviewed]
  English, Scientific journal
• Avirulent Avian Influenza Virus as a Vaccine Strain against a Potential Human Pandemic
  Takada Ayato; Kuboki Noritaka; Okazaki Katsunori; Ninomiya Ai; Tanaka Hiroko; Ozaki Hiroichi; Itamura Shigeyuki; Nishimura Hidekazu; Enami Masayoshi; Tashiro Masato; Shortridge Kennedy F; Kida Hiroshi
  Journal of Virology, 73, 10, 8303, 8307, American Society for Microbiology, Oct. 1999
  English, In the influenza H5N1 virus incident in Hong Kong in 1997, viruses that are closely related to H5N1 viruses initially isolated in a severe outbreak of avian influenza in chickens were isolated from humans, signaling the possibility of an incipient pandemic. However, it was not possible to prepare a vaccine against the virus in the conventional embryonated egg system because of the lethality of the virus for chicken embryos and the high level of biosafety therefore required for vaccine production. Alternative approaches, including an avirulent H5N4 virus isolated from a migratory duck as a surrogate virus, H5N1 virus as a reassortant with avian virus H3N1 and an avirulent recombinant H5N1 virus generated by reverse genetics, have been explored. All vaccines were formalin inactivated. Intraperitoneal immunization of mice with each of vaccines elicited the production of hemagglutination-inhibiting and virus-neutralizing antibodies, while intranasal vaccination without adjuvant induced both mucosal and systemic antibody responses that protected the mice from lethal H5N1 virus challenge. Surveillance of birds and animals, particularly aquatic birds, for viruses to provide vaccine strains, especially surrogate viruses, for a future pandemic is stressed.
• Resistance to pseudorabies virus infection in transgenic mice expressing the chimeric transgene that represses the immediate-early gene transcription.
  Ono E; Tasaki T; Kobayashi T; Taharaguchi S; Nikami H; Miyoshi I; Kasai N; Arikawa J; Kida H; Shimizu Y
  Virology, 262, 1, 72, 78, 1, Sep. 1999, [Peer-reviewed]
• Replacement of Internal Protein Genes, with the Exception of the Matrix, in Equine 1 Viruses by Equine 2 Influenza Virus Genes during Evolution in Nature
  Toshihiro Ito; Yoshihiro Kawaoka; Maki Ohira; Hiroki Takakuwa; Jiro Yasuda; Hiroshi Kida; Koichi Otsuki
  Journal of Veterinary Medical Science, 61, 8, 987, 989, Aug. 1999, [Peer-reviewed]
  English, Scientific journal
• Differences in Receptor Specificity between Newcastle Disease Viruses Originating from Chickens and Waterfowl
  Toshihiro Ito; Yoshihiro Kawaoka; Chinatsu Kameda; Jiro Yasuda; Hiroshi Kida; Koichi Otsuki
  Journal of Veterinary Medical Science, 61, 8, 951, 953, Aug. 1999, [Peer-reviewed]
  English, Scientific journal
• Detection of Canine Herpesvirus DNA in the Ganglionic Neurons and the Lymph Node Lymphocytes of Latently Infected Dogs
  Masahiro Miyoshi; Yuki Ishii; Mitsuyoshi Takiguchi; Ayato Takada; Jun Yasuda; Akira Hashimoto; Katsunori Okazaki; Hiroshi Kida
  Journal of Veterinary Medical Science, 61, 4, 375, 379, Apr. 1999, [Peer-reviewed]
  English, Scientific journal
• Antigenic and genetic analyses of H5 influenza viruses isolated from ducks in Asia
  IMAI Masaki; TAKADA Ayato; OKAZAKI Katsunori; KIDA Hiroshi
  Japanese journal of veterinary research, 46, 4, 171, 177, Hokkaido University, 26 Feb. 1999
  English, The hemagglutinin (HA) of six H5 influenza virus strains isolated from ducks in Japan and China in 1976 to 1996 were analyzed antigenically and genetically. Antigenic analysis using a panel of monoclonal antibodies revealed that the HA of H5 influenza viruses isolated from ducks are antigenically closely related to each other. Phylogenetic analysis indicates that the isolates from ducks in Hokkaido were derived from an ancestor common with the highly pathogenic isolates from chickens and humans in Hong Kong in 1997.
• The role of monocyte chemotactic and activating factor(MCAF)/monocyte chemoattractant protein (MCP)-l in subgroups of rapidly progressive glomerulonephritis
  Norihiko Sakai; Takashi Wada; Kengo Furuichi; Chikako Takaeda; Miho Shimizu; Yasunori Iwata; Kei-Ichi Yoshimoto; Kazuaki Shimizu; Ken-Ichi Kobayashi; Shin-Ichi Takeda; Hiroshi Kida; Naofumi Mukaida; Kouji Matsushima; Hitoshi Yokoyama
  Japanese Journal of Nephrology, 41, 7, 704, 711, 1999, [Peer-reviewed]
  English, Scientific journal
• The short- and long-term outcomes of membranous nephropathy treated with intravenous immune globulin therapy
  Hitoshi Yokoyama; Satoshi Goshima; Takashi Wada; Masayoshi Takaeda; Kengo Furuichi; Ken-Ichi Kobayashi; Hiroshi Kida
  Nephrology Dialysis Transplantation, 14, 10, 2379, 2386, 1999, [Peer-reviewed]
  English, Scientific journal
• Structure of the immediate early gene of canine herpesvirus.
  Miyoshi M; Takiguchi M; Yasuda J; Hashimoto A; Takada A; Okazaki K; Kida H
  Archives of Virology, 144, 2, 407, 420, 1999, [Peer-reviewed]
  English, Scientific journal
• Induction of antibodies in mice by a recombinant baculovirus expressing pseudorabies virus glycoprotein B in mammalian cells.
  Aoki H; Sakoda Y; Jukuroki K; Takada A; Kida H; Fukusho A
  Veterinary Microbiology, 68, 197, 207, 1999, [Peer-reviewed]
  English, Scientific journal
• Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice.
  Takada A; Okazaki K; Kida H
  Japanese Journal of Veterinary Research, 47, 25, 33, 1999, [Peer-reviewed]
  English, Scientific journal
• Substitution of amino acid residue in influenza A virus hemagglutinin affects recognition of sialyl-oligosaccharides containing N-glycolylneuraminic acid.
  Masuda H; Suzuki T; Sugiyama Y; Horiike G; Murakami K; Miyamoto D; Hidari I-PJK; Ito T; Kida H; Kiso M; Fukunaga K; Ohuchi T; Toyoda T; Ishihama A; Kawaoka Y; Suzuki Y
  FEBS Lett., 464, 1月2日, 71, 74, 1999, [Peer-reviewed]
  English, Scientific journal
• Replacement of internal protein genes, with the exception on the matrix, ix equine 1 viruses by equine 2 influenza virus genes during evolution in nature
  Ito T; Kawaoka Y; Ohira M; Takakuwa H; Yasuda J; Kida H; Otsuki K
  J. Vet. Med. Sci., 61, 8, 987, 989, 1999, [Peer-reviewed]
  English, Scientific journal
• Differences in receptor specificity between newcastle disease viruses originating from chickens and waterfowl
  Ito T; Kawaoka Y; Kameda C; Yasuda J; Kida H; Otsuki K
  J. Vet. Med. Sci, 61, 8, 951, 953, 1999, [Peer-reviewed]
  English, Scientific journal
• Pseudorabies virus (PRV) early protein 0 activates PRV gene transcription in combination with the immediate-early protein IE180 and enhances the infectivity of PRV genomic DNA.
  Ono E; Watanabe S; Nikami H; Tasaki T; Kida H
  Veterinary microbiology, 63, 2-4, 99, 107, Oct. 1998, [Peer-reviewed]
• Molecular basis for the generation in pigs of influenza A viruses with pandemic potential
  T Ito; JNSS Couceiro; S Kelm; LG Baum; S Krauss; MR Castrucci; Donatelli, I; H Kida; JC Paulson; RG Webster; Y Kawaoka
  JOURNAL OF VIROLOGY, 72, 9, 7367, 7373, Sep. 1998, [Peer-reviewed]
  English, Scientific journal
• Promoter activity of sequence located upstream of the pseudorabies virus early protein 0 gene.
  Watanabe S; Ono E; Nikami H; Kida H
  Veterinary microbiology, 61, 1-2, 7, 19, Mar. 1998, [Peer-reviewed]
• Suppression of pseudorabies virus replication by a mutant form of immediate-early protein IE180 repressing the viral gene transcription.
  Ono E; Taharaguchi S; Watanabe S; Nikami H; Shimizu Y; Kida H
  Veterinary microbiology, 60, 2-4, 107, 117, Feb. 1998, [Peer-reviewed]
• Fusion of influenza virus with the endosomal membrane is inhibited by monoclonal antibodies to defined epitopes on the hemagglutinin.
  Imai M; Sugimoto K; Okazaki K; Kida H
  Virus research, 53, 2, 129, 139, 2, Feb. 1998, [Peer-reviewed]
• Characteristics of Renal Survival Rate in Crescentic Glomerulonephritis -Analysis Using Weibull'S Distribution Function
  Hiroshi Kida; Mitsuhiro Yoshimura; Kazuya Takasawa; Tamayo Kato; Kishichiro Watanabe; Keiko Kawabata
  IRYO - Japanese Journal of National Medical Services, 52, 10, 596, 600, 1998, [Peer-reviewed]
  English, Scientific journal
• Methylprednisolone pulse therapy in two clinical types of crescentic glomerulonephritis
  Shin-Ichi Takeda; Hiroshi Kida; Hitoshi Yokoyama; Eisuke Takazakura; Ken-Ichi Kobayashi
  Internal Medicine, 37, 7, 585, 591, Japanese Society of Internal Medicine, 1998, [Peer-reviewed]
  English, Scientific journal
• Molecular basis for the generation of pandemic influenza viruses in pigs.
  Ito T; Nelson J; Couseiro SS; Kelm S; Baum LG; Castrucci MR; Donatelli I; Kida H; Paulson JC; Webster RG; Kawaoka Y
  J. Virol., 72, 9, 7367, 7373, 1998, [Peer-reviewed]
  English, Scientific journal
• An attenuation mechanism of Newcastle disease vaccine strain TCND.
  Takakuwa H; Ito T; Takada A; Okazaki K; Kida H
  Arch. Virol, 143, 6, 1129, 1143, 1998, [Peer-reviewed]
  English, Scientific journal
• Continued circulation of reassortant H1N2 influenza viruses in pigs in Japan.
  Ito T; Kawaoka Y; Vines A; Ishikawa H; Asai T; Kida H
  Arch. Virol., 143, 9, 1773, 1782, 1998, [Peer-reviewed]
  English, Scientific journal
• Potential virulent Newcastle disease viruses are maintained in migratory waterfowl populations.
  Takakuwa H; Ito T; Takada A; Okazaki K; Kida H
  Jap. J. Vet. Res., 45, 4, 207, 215, 1998, [Peer-reviewed]
  English, Scientific journal
• Effects of methylprednisolone pulse therapy on the insidious type of crescentic glomerulonephritis
  Shin-Ichi Takeda; Hiroshi Kida; Eisuke Takazakura; Hitoshi Yokoyama; Ken-Ichi Kobayashi
  Japanese Journal of Nephrology, 39, 5, 490, 496, 1997, [Peer-reviewed]
  Japanese, Scientific journal
• Spinal cord compression by heterotopic ossification associated with pseudohypoparathyroidism
  Y. Yamamoto; Y. Noto; M. Saito; H. Ichizen; H. Kida
  Journal of International Medical Research, 25, 6, 364, 368, SAGE Publications Ltd, 1997, [Peer-reviewed]
  English, Scientific journal
• Adaptation of equine herpesvirus 1 to unnatural host led to mutation of the gC resulting in increased susceptibility of the virus to heparin.
  Sugahara Y; Matsumura T; Kono Y; Honda E; Kida H; Okazaki K
  Archives of virology, 142, 9, 1849, 1856, 9, 1997, [Peer-reviewed]
• Swine influenza virus strains recognize sialylsugar chains containing the molecular species of sialic acid predominantly present in the swine tracheal epitherium.
  Suzuki T; Horiike G; Yamazaki Y; Kawabe K; Masuda H; Miyamoto D; Matsuda M; Nishimura S; Yamagata T; Ito T; Kida H; Kawaoka Y; Suzuki Y
  FEBS Letter, 404, 2月3日, 192, 196, 1997, [Peer-reviewed]
  English, Scientific journal
• Differences in sialic acid-galactose linkages in the amnion and allantois of chicken eggs influence human influenza virus receptor specificity and variant selection.
  Ito T; Suzuki Y; Takada A; Kawamoto A; Otsuki K; Masuda H; Yamada M; Suzuki T; Kida H; Kawaoka Y
  Journal of Virology, 71, 3357, 3362, 1997, [Peer-reviewed]
  English, Scientific journal
• Receptor specificity of influenza A viruses correlates with the agglutination of erythrocytes from different animal species.
  Ito T; Suzuki Y; Mitnaul L; Vines A; Kida H; Kawaoka Y
  Virology, 227, 2, 493, 499, 1997, [Peer-reviewed]
  English, Scientific journal
• Bovine clostridial infections in Zambia (1985-1994)
  HM Munangandu; PM Muyoyeta; AS Mweene; H Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 44, 3, 175, 178, Dec. 1996, [Peer-reviewed]
  English, Scientific journal
• Negative regulation of immediate-early gene expression of pseudorabies virus by interferon-alpha
  N Tonomura; E Ono; Y Shimizu; H Kida
  VETERINARY MICROBIOLOGY, 53, 3-4, 271, 281, Dec. 1996, [Peer-reviewed]
  English, Scientific journal
• Detection of viral genome in non-neural tissues of cattle experimentally infected with bovine herpesvirus 1
  AS Mweene; K Okazaki; H Kida
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 44, 3, 165, 174, Dec. 1996, [Peer-reviewed]
  English, Scientific journal
• Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: Amino acid sequence at the HA cleavage site as a marker of pathogenicity potential
  DA Senne; B Panigrahy; Y Kawaoka; JE Pearson; J Suss; M Lipkind; H Kida; RG Webster
  AVIAN DISEASES, 40, 2, 425, 437, Apr. 1996, [Peer-reviewed]
  English, Scientific journal
• Mapping of transregulatory domains of pseudorabies virus early protein 0 and identification of its dominant-negative mutant
  S Watanabe; E Ono; Y Shimizu; H Kida
  ARCHIVES OF VIROLOGY, 141, 6, 1001, 1009, 1996, [Peer-reviewed]
  English, Scientific journal
• Protective immune response of chickens against Newcastle disease, induced by the intranasal vaccination with inactivated virus.
  Takada A; Kida H
  Veterinary Microbiology, 50, 17, 25, 1996, [Peer-reviewed]
  English, Scientific journal
• Avian influenza viruses as the origin of pandemic strains : perpetuation in nature and potential for transmission to pigs.
  Kida H; Ito T; Okazaki K; Kawaoka Y; Webster RG
  Options for the control of influenza III, 529, 536, 1996, [Peer-reviewed]
  English, Scientific journal
• Receptors of influenza A viruses : Implications for the role of pigs for the generation of pandemic human influenza viruses .
  Ito T; Kida H; Kawaoka Y
  Options for the control of influenza III, 516, 519, 1996, [Peer-reviewed]
  English, Scientific journal
• Development of immuno-PCR for diagnosis of bovine herpes virus 1 infection.
  Mweene AS; Ito T; Okazaki K; Ono E; Shimizu Y; Kida, H
  Journal of Clinical Microbiology, 34, 748, 750, 1996, [Peer-reviewed]
  English, Scientific journal
• Pseudorabies virus early protein 0 transactivates the viral gene promoters.
  Watanabe S; Ono E; Shimizu Y; Kida H
  The Journal of general virology, 76 ( Pt 11), 2881, 2885, Nov. 1995, [Peer-reviewed]
• Inhibition of pseudorabies virus replication by a chimeric trans-gene product repressing transcription of the immediate-early gene.
  Ono E; Sakoda Y; Taharaguchi S; Watanabe S; Tonomura N; Kida H; Shimizu Y
  Virology, 210, 1, 128, 140, Jun. 1995, [Peer-reviewed]
• MAPPING OF A FUNCTIONAL REGION CONFERRING NUCLEAR-LOCALIZATION OF PSEUDORABIES VIRUS IMMEDIATE-EARLY PROTEIN
  S TAHARAGUCHI; E ONO; S YAMADA; Y SHIMIZU; H KIDA
  ARCHIVES OF VIROLOGY, 140, 10, 1737, 1746, 1995, [Peer-reviewed]
  English, Scientific journal
• Induction of protective antibody responses against pseudorabies virus by intranasal vaccination with glycoprotein B in mice.
  Takada A; Kida H
  Archives of Virology, 140, 9, 1629, 1635, 1995, [Peer-reviewed]
  English, Scientific journal
• Perpetuation of influenza A viruses in Alaskan waterfowl reservoirs.
  Ito T; Okazaki K; Kawaoka Y; Takada A; Webster RG; Kida H
  Archeives of Virology, 140, 7, 1163, 1172, 1995, [Peer-reviewed]
  English, Scientific journal
• Brain lesions in young broiler chickens naturally infected with a mesogenic strain of Newcastle disease virus.
  Bhaiyat MI; Ochiai K; Itakura C; Islam MA; Kida H
  Avian pathology : journal of the W.V.P.A, 23, 693, 708, 4, Dec. 1994, [Peer-reviewed]
• Mapping of transcriptional regulatory domains of pseudorabies virus immediate-early protein
  S. Taharaguchi; H. Inoue; E. Ono; H. Kida; S. Yamada; Y. Shimizu
  Archives of Virology, 137, 3-4, 289, 302, Springer-Verlag, Sep. 1994, [Peer-reviewed]
  English, Scientific journal
• A NEUTRAL SUGAR IS RESPONSIBLE FOR SEROVAR SPECIFICITY OF THE ANTIGENIC DETERMINANT OF LEPTOSPIRA-INTERROGANS SEROVAR CANICOLA
  H KASHIWASE; E ONO; R YANAGAWA; Y SHIMIZU; H KIDA
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 42, 2, 103, 108, Aug. 1994, [Peer-reviewed]
  English, Scientific journal
• Magnetic resonance imaging findings in Japanese encephalitis: White matter lesions
  H. Shoji; H. Kida; H. Hino; S. Matsuura; K. Kojima; T. Abe; H. Utsunomiya; Y. Okada; Y. Nakamura; T. Okudera
  Journal of Neuroimaging, 4, 4, 206, 211, Blackwell Publishing Inc., 1994, [Peer-reviewed]
  English, Scientific journal
• A potential peptide vaccine against two different strains of influenza virus isolated at intervals of about 10 years.
  Naruse H; Ogasawara K; Kaneda R; Hatakeyama S; Ito T; Kida H; Miyazaki T; Good RA; Onoe K
  Proceeding of National Academy of Science, USA, 91, 20, 9588, 9592, 1994, [Peer-reviewed]
  English, Scientific journal
• Potential for transmission of avian influenza viruses to pigs.
  Kida H; Ito T; Yasuda J; Shimizu Y; Itakura C; Shortridge KF; Kawaoka Y; Webster RG
  Journal of General Virology, 75, 1, 2183, 2188, 1994, [Peer-reviewed]
  English, Scientific journal
• Acquisition of pathogenicity of a newcastle disease virus isolated from a Japanese quail by intracerebral passage in chickens.
  Islam MA; Ito T; Takakuwa H; Takada A; Itakura C; Kida H
  Japanese Journal of Veterinary Research, 42, 3月4日, 147, 156, 1994, [Peer-reviewed]
  English, Scientific journal
• Antigenic drift of equine H3N8 influenza viruses.
  Kida H; Shimizu A; Ito T; Shimizu Y
  Equine Infectious Disease VII, 307, 1994, [Peer-reviewed]
  English, Scientific journal
• Shortening of life expectancy in patients with membranous nephropathy — based on 20 years follow up study —
  Makoto Ogi; Hiroshi Kida; Mitsuhiro Yoshimura; Yafumi Saito; Yoshinori Kibe; Gorou Sugioka; Kenzo Ikeda; Teruo Asamoto; Hitoshi Yokoyama; Naohisa Tomosugi
  the japanese journal of nephrology, 35, 10, 1147, 1153, 1993, [Peer-reviewed]
  English, Scientific journal
• Adrenocortical carcinoma with a giant pericardial mass
  Akio Nakata; Shinji Yagi; Koichi Oyama; Hiroshi Kida; Goro Sugioka
  Internal Medicine, 32, 5, 438, 440, 1993, [Peer-reviewed]
  English, Scientific journal
• A STRATEGY FOR MAKING SYNTHETIC PEPTIDE VACCINES
  K OGASAWARA; H NARUSE; Y ITOH; T GOTOHDA; J ARIKAWA; H KIDA; RA GOOD; K ONOE
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 89, 19, 8995, 8999, Oct. 1992, [Peer-reviewed]
  English, Scientific journal
• Effect of Sendai Virus Exposure on the Development of Frozen-Thawed Mouse Embryos
  Carmencita Lavilla-Apelo; Antonio Arenas Rayos; Hiroshi Kida; Hiroshi Kanagawa
  Journal of Reproduction and Development, 38, 3, 225, 228, 1992, [Peer-reviewed]
  English, Scientific journal
• Effectiveness of steroid pulse therapy on progressive IgA nephropathy
  Mitsuhiro Yoshimura; Hiroshi Kida; Yafumi Saito; Kihitiro Watanabe; Goro Sugioka
  japanese journal of national medical services, 46, 8, 657, 663, 1992, [Peer-reviewed]
  English, Scientific journal
• A Patient with Asymptomatic Primary Biliary Cirrhosis Associated with Eosinophilic Infiltration and Peripheral Eosinophilia Improved By the Administration of Ursodeoxycholic Acid
  Masakazu Yamazaki; Hideo Morimoto; Tokio Wakabayashi; Kunihiko Suzuki; Hiroshi Kida; Goto Sugioka
  Kanzo, 33, 4, 348, 352, 1992, [Peer-reviewed]
  English, Scientific journal
• Steroid pulse therapy in rapidly progressive glomerulonephritis
  Makoto Ogi; Mitsuhiro Yoshimura; Kenzo Ikeda; Yafumi Saito; Hiroshi Kida; Gorou Sugioka; Kihichirou Watanabe
  The Japanese Journal of Nephrology, 34, 6, 669, 675, 1992, [Peer-reviewed]
  English, Scientific journal
• THE EFFECTIVENESS OF TRYPSIN TREATMENT TO REMOVE SENDAI VIRUS ADHERING TO THE ZONA-PELLUCIDA OF MOUSE PREIMPLANTATION EMBRYOS
  C LAVILLAAPELO; H KIDA; H KANAGAWA
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 39, 2-4, 133, 141, Dec. 1991, [Peer-reviewed]
  English, Scientific journal
• THE INFECTION OF MOUSE PREIMPLANTATION EMBRYOS TO SENDAI VIRUS (PARAINFLUENZA-I)
  C LAVILLAAPELO; K OHTA; H KIDA; H KANAGAWA
  THERIOGENOLOGY, 36, 1, 87, 94, Jul. 1991, [Peer-reviewed]
  English, Scientific journal
• Etiology of Rabbit Haemorrhagic Disease Spontaneously Occurring in Korea
  J. H. Park; H. Kida; K. Ueda; K. Ochiai; M. Goryo; C. Itakura
  Journal of Veterinary Medicine, Series B, 38, 1-10, 749, 754, 1991, [Peer-reviewed]
  English, Scientific journal
• Influences of pregnancy on the natural course of chronic glomerulonephritis with impaired renal function
  Shin-Ichi Takeda; Hiroshi Kida; Kazuya Takasawa; Kenzo Ikeda; MlTSUHIRO Yoshimura; HlTOSHI Yokoyama; Naohisa Tomosugi; Ken-ichi Kobayashi
  The Japanese Journal of Nephrology, 33, 8, 803, 810, 1991, [Peer-reviewed]
  English, Scientific journal
• Pathogenesis of diabetic nephropathy in non-insulin-dependent diabetes mellitus
  Hiroshi Kida; Mituhiro Yoshimura; Kenzo Ikeda; Yafumi Saitou; Yutaka Noto
  Journal of Diabetic Complications, 5, 2-3, 82, 83, 1991, [Peer-reviewed]
  English, Scientific journal
• A case of caroli's disease. the evaluation of MRI findings
  Tokio Wakabayashi; Hideo Morimoto; Kunihiko Suzuki; Goroh Sugioka; Sakae Taira; Hiroshi Kida; Kishichiroh Watanabe
  Kanzo, 32, 9, 884, 889, 1991, [Peer-reviewed]
  English, Scientific journal
• Molecular evidence for a role of domestic ducks in the introduction of avian H3 influenza viruses to pigs in southern China, where the A/Hong Kong/68 (H3N2) strain emerged
  J. Yasuda; K. F. Shortridge; Y. Shimizu; H. Kida
  Journal of General Virology, 72, 8, 2007, 2010, Jan. 1991, [Peer-reviewed]
  English, Scientific journal
• Acute toxoplasma myositis: an immunohistochemical and ultrastructural study
  S. Matsubara; M. Takamori; H. Adachi; H. Kida
  Acta Neuropathologica, 81, 2, 223, 227, Springer-Verlag, Dec. 1990, [Peer-reviewed]
  English, Scientific journal
• Primary glomerular fibrosis: a new nephropathy caused by diffuse intra-glomerular increase in atypical type III collagen fibers
  K. Ikeda; H. Yokoyama; N. Tomosughi; H. Kida; A. Ooshima; K. Kobayashi
  Clinical Nephrology, 33, 4, 155, 159, 1990, [Peer-reviewed]
  English, Scientific journal
• A Case of Diffuse Panbronchiolitis(DPB) with Benign Monoclonal IgA Gammopathy and IgA Nephropathy with Monoclonal IgA Deposition
  Takero Naito; Hitoshi Yokoyama; Yoshitaka Koshino; Naohisa Tomosugi; Nobu Hattori; Hiroshi Kida; Kunihiko Kobayashi
  Japanese Journal of Medicine, 28, 4, 503, 505, 1989, [Peer-reviewed]
  English, Scientific journal
• Influence of pregnancy on IgA nephropathy
  Shin-ichi Takeda; Hiroshi Kida; Kazuya Takasawa; Kenzo Ikeda; Masahiro Katagiri; Mitsuhiro Yoshimura; Hitoshi Yokoyama; Naohisa Tomosugi; Nobu Hattori
  The Japanese Journal of Nephrology, 31, 1, 67, 75, 1989, [Peer-reviewed]
  English, Scientific journal
• Origin of the hemagglutinin gene of A/Hong Kong/68 (H3N2) influenza virus.
  Kida H; Webster RG; Kawaoka Y; Shortridge KF; Naeve CV; Ito T; Itakura C; Mori F; Shimizu Y
  Current Topics in Medical Virology, 365, 376, 1989, [Peer-reviewed]
  English, Scientific journal
• Clinicopathological characteristics of IgA nephropathy with acute onset: Comparative study with IgA nephropathy with insidious onset and purpura nephritis
  Masahiro Katagiri; Hiroshi Kida; Takerou Naitou; Kazuya Takasawa; Shin-Ichi Takeda; Mitsuhiro Yoshimura; Hitoshi Yokoyama; Yoshitaka Koshino; Toshio Abe; Nobu Hattori
  The Japanese Journal of Nephrology, 30, 1, 1, 7, 01 Feb. 1988, [Peer-reviewed]
  English, Scientific journal
• Characteristics of Glomerular Lesions in Hepatitis B Virus Infection
  Shin-ichi Takeda; Hiroshi Kida; Masahiro Katagiri; Hitoshi Yokoyarna; Toshio Abe; Nobu Hattori
  American Journal of Kidney Diseases, 11, 1, 57, 62, 1988, [Peer-reviewed]
  English, Scientific journal
• Identification of amino acids relevant to three antigenic determinants on the fusion protein of Newcastle disease virus that are involved in fusion inhibition and neutralization
  T. Toyoda; B. Gotoh; T. Sakaguchi; H. Kida; Y. Nagai
  Journal of Virology, 62, 11, 4427, 4430, 1988, [Peer-reviewed]
  English, Scientific journal
• Mesangiolysis in diabetic glomeruli: Its role in the formation of nodular lesions
  Y. Saito; H. Kida; S. I. Takeda; M. Yoshimura; H. Yokoyama; Y. Koshino; N. Hattori
  Kidney International, 34, 3, 389, 396, 1988, [Peer-reviewed]
  English, Scientific journal
• ORIGIN OF THE HEMAGGLUTININ GENE OF H3N2 INFLUENZA-VIRUSES FROM PIGS IN CHINA
  H KIDA; KF SHORTRIDGE; RG WEBSTER
  VIROLOGY, 162, 1, 160, 166, Jan. 1988, [Peer-reviewed]
  English, Scientific journal
• ANTIGENIC AND GENETIC CONSERVATION OF H-3 INFLUENZA-VIRUS IN WILD DUCKS
  H KIDA; Y KAWAOKA; CW NAEVE; RG WEBSTER
  VIROLOGY, 159, 1, 109, 119, Jul. 1987, [Peer-reviewed]
  English, Scientific journal
• Impaired immunoglobulin G production in minimal change nephrotic syndrome in adults
  H. Yokoyama; H. Kida; T. Abe; Y. Koshino; M. Yoshimura; N. Hattori
  Clinical and Experimental Immunology, 70, 1, 110, 115, 1987, [Peer-reviewed]
  English, Scientific journal
• Participation of renal tubular epithelial antigen and HLA-DR antigen in pathogenesis of membranous nephropathy
  Hitoshi Yokoyama; Hiroshi Kida; Takero Naito; Kenzo Ikeda; Shin-Ichi Takeda; Mitsuhiro Yoshimura; Yoshitaka Koshino; Naohisa Tomosugi; Toshio Abe; Nobu Hattori
  Japanese Journal of Nephrology, 29, 8, 995, 1002, 1987, [Peer-reviewed]
  English, Scientific journal
• Glomerular capillary wall immune deposits in IgA nephropathy and purpura nephritis
  Mitsuhiro Yoshimura; Hiroshi Kida; Takerou Naitou; Satosi Goshima; Kazuya Takasawa; Shin-Ichi Takeda; Hitoshi Yokoyama; Yoshitaka Koshino; Toshio Abe; Nobu Hattori
  Japanese Journal of Nephrology, 29, 8, 1077, 1085, 1987, [Peer-reviewed]
  English, Scientific journal
• Re-pregnancy in patients with preeclamptic focal glomerular sclerosis
  Kazuya Takasawa; Hiroshi Kida; Shin-Ichi Takeda; Satoshi Goshima; Kenzo Ikeda; Mitsuhiro Yoshimura; Hitoshi Yokoyama; Yoshitaka Koshino; Toshio Abe; Nobu Hattori
  Japanese Journal of Nephrology, 29, 4, 401, 407, 1987, [Peer-reviewed]
  English, Scientific journal
• Significance of IgA Deposits on the Glomerular Capillary Walls in IgA Nephropathy
  Mitsuhiro Yoshimura; Hiroshi Kida; Toshio Abe; Shin-ichi Takeda; Masahiro Katagiri; Nobu Hattori
  American Journal of Kidney Diseases, 9, 5, 404, 409, 1987, [Peer-reviewed]
  English, Scientific journal
• Effect of high-dose β-globulin therapy on membranous nephropathy
  Naohisa Tomosugi; Hiroshi Kida; Hitoshi Yokoyama; Kenzo Ikeda; Yoshitaka Koshino; Eruo Asamoto; Toshio Abe; Nobu Hattori
  Japanese Journal of Nephrology, 29, 1, 81, 86, 1987, [Peer-reviewed]
  English, Scientific journal
• SPIN-LABELING OF INFLUENZA-VIRUS HEMAGGLUTININ PERMITS ANALYSIS OF THE CONFORMATIONAL CHANGE AT LOW PH AND ITS INHIBITION BY ANTIBODY
  S YODEN; H KIDA; M KUWABARA; R YANAGAWA; RG WEBSTER
  VIRUS RESEARCH, 4, 3, 251, 261, May 1986, [Peer-reviewed]
  English, Scientific journal
• Characteristics of glomerular lesions in hepatitis B virus infection
  Shin-Ichi Takeda; Hiroshi Kida; Masahiro Katagiri; Katsumi Hirahara; Mitsuhiro Yoshimura; Hitoshi Yokoyama; Yoshitaka Koshino; Naohisa Tomosugi; Toshio Abe; Nobu Hattori
  The Japanese Journal of Nephrology, 28, 4, 413, 420, 1986, [Peer-reviewed]
  English, Scientific journal
• Glomerular lesions in primary biliary cirrhosis
  Yoshitaka Koshino; Hiroshi Kida; Kazuya Takasawa; Satoshi Goshima; Shin-Ichi Takeda; Mituhiro Yoshimura; Hitoshi Yokoyama; Naohisa Tomosugi; Toshio Abe; Nobu Hattori
  The Japanese Journal of Nephrology, 28, 10, 1385, 1391, 1986, [Peer-reviewed]
  English, Scientific journal
• Participation of extracapillary lesions (ECL) in progression of IgA nephropathy
  T. Abe; H. Kida; M. Yoshimura; H. Yokoyama; Y. Koshino; N. Tomosugi; N. Hattori
  Clinical Nephrology, 25, 1, 37, 41, 1986, [Peer-reviewed]
  English, Scientific journal
• ANTIGENIC MAPPING AND FUNCTIONAL-ANALYSIS OF THE F-PROTEIN OF NEWCASTLE-DISEASE VIRUS USING MONOCLONAL-ANTIBODIES
  G ABENES; H KIDA; R YANAGAWA
  ARCHIVES OF VIROLOGY, 90, 1-2, 97, 110, 1986, [Peer-reviewed]
  English, Scientific journal
• Focal glomerular sclerosis in pre-eclampsia
  H. Kida; S. Takeda; H. Yokoyama; N. Tomosugi; T. Abe; N. Hattori
  Clinical Nephrology, 24, 5, 221, 227, 1985, [Peer-reviewed]
  English, Scientific journal
• Organic glomerular lesions in toxemia of pregnancy
  Shinichi Takeda; Hiroshi Kida; Mitsuhiro Yoshimura; Hitoshi Yokoyama; Yoshitaka Koshino; Teruo Asamoto; Naohisa Tomosugi; Toshio Abe; Nobu Hattori
  The Japanese Journal of Nephrology, 27, 6, 803, 813, 1985, [Peer-reviewed]
  English, Scientific journal
• Inhibition of transcriptase activity of influenza A virus in vitro by anti-haemagglutinin antibodies
  Kazufumi Shimizu; Jun Mukaigawa; Mieko Oguro; Yasushi Ono; Katsuhisa Nakajima; Hiroshi Kida
  Vaccine, 3, 3, 207, 210, 1985, [Peer-reviewed]
  English, Scientific journal
• Immunoglobulin-producing cells in minimal change nephrotic syndrome (MCNS)
  Hitoshi Yokoyama; Hiroshi Kida; Yoshio tani; Yoshitaka Koshino; Shin-Ichi Takeda; Mitsuhiro Yoshimura; Naohisa Tomosugi; Toshio Abe; Nobu Hattori
  The Japanese Journal of Nephrology, 27, 6, 773, 780, 1985, [Peer-reviewed]
  English, Scientific journal
• Immunodynamics of focal glomerular sclerosis
  Hitoshi Yokoyama; Hiroshi Kida; Tomosugi Aohisa; Masahiro Katagiri; Katsumi Hirahara; Shin-ichi Takeda; Mitsuhiro Yoshimura; Yoshitaka Koshino; Toshio Abe; Nobu Hattori
  The Japanese Journal of Nephrology, 27, 8, 1095, 1101, 1985, [Peer-reviewed]
  English, Scientific journal
• Survival of Corynebacterium renale, Corynebacterium pilosum and Corynebacterium cystitidis in soil
  Aoi Hayashi; Ryo Yanagawa; Hiroshi Kida
  Veterinary Microbiology, 10, 4, 381, 386, 1985, [Peer-reviewed]
  English, Scientific journal
• Adhesion of Corynebacterium renale and Corynebacterium pilosum to the epithelial cells of various parts of the bovine urinary tract from the renal pelvis to vulva
  Aoi Hayashi; Ryo Yanagawa; Hiroshi Kida
  Veterinary Microbiology, 10, 3, 287, 292, 1985, [Peer-reviewed]
  English, Scientific journal
• IS BIVALENT BINDING OF MONOCLONAL-ANTIBODIES TO DIFFERENT ANTIGENIC AREAS ON THE HEMAGGLUTININ OF INFLUENZA-VIRUS REQUIRED FOR NEUTRALIZATION OF VIRAL INFECTIVITY
  S YODEN; H KIDA; R YANAGAWA
  ARCHIVES OF VIROLOGY, 85, 3-4, 209, 216, 1985, [Peer-reviewed]
  English, Scientific journal
• INTERFERENCE WITH A CONFORMATIONAL CHANGE IN THE HEMAGGLUTININ MOLECULE OF INFLUENZA-VIRUS BY ANTIBODIES AS A POSSIBLE NEUTRALIZATION MECHANISM
  H KIDA; S YODEN; M KUWABARA; R YANAGAWA
  VACCINE, 3, 3, 219, 222, 1985, [Peer-reviewed]
  English, Scientific journal
• DETECTION OF ANTIBODIES TO LEPTOSPIRAL GENUS-SPECIFIC ANTIGEN IN HUMAN AND ANIMAL SERA BY INDIRECT HEMAGGLUTINATION TEST WITH A PARTIALLY PURIFIED GENUS-SPECIFIC PROTEIN ANTIGEN
  N SAKAMOTO; R YANAGAWA; E ONO; H KIDA; M MORI; Y ARIMITSU; K AKAMA; J YASUDA; K TOO
  ZENTRALBLATT FUR BAKTERIOLOGIE MIKROBIOLOGIE UND HYGIENE SERIES A-MEDICAL MICROBIOLOGY INFECTIOUS DISEASES VIROLOGY PARASITOLOGY, 259, 4, 548, 556, 1985, [Peer-reviewed]
  English, Scientific journal
• PRODUCTION OF MONOCLONAL-ANTIBODIES AGAINST LEPTOSPIRAL GENUS-SPECIFIC PROTEIN ANTIGEN AND LOCALIZATION OF THE ANTIGEN BY IMMUNOELECTRON MICROSCOPY
  N SAKAMOTO; E ONO; H KIDA; R YANAGAWA
  ZENTRALBLATT FUR BAKTERIOLOGIE MIKROBIOLOGIE UND HYGIENE SERIES A-MEDICAL MICROBIOLOGY INFECTIOUS DISEASES VIROLOGY PARASITOLOGY, 259, 4, 557, 563, 1985, [Peer-reviewed]
  English, Scientific journal
• Antigenic analysis of H4 influenza virus isolates using monoclonal antibodies to defined antigenic sites on the hemagglutinin of A/budgerigar/Hokkaido/1/77 strain.
  Ito T; Kida H; Yanagawa R
  Archeives of Virology, 84, 251, 259, 1985, [Peer-reviewed]
  English, Scientific journal
• The Significance of Predominant IgM Deposition in Glomerular Diseases
  Yoshitaka Koshino; Hiroshi Kida; Hitoshi Yokoyama; Mitsuhiro Yoshimura; Teruo Asamoto; Yafumi Saito; Naohisa Tomosugi; Toshio Abe; Nobu Hattori
  The Japanese Journal of Nephrology, 26, 10, 1293, 1300, 1984, [Peer-reviewed]
  English, Scientific journal
• Intermediate type of primary glomerulonephritis between mesangial proliferative and membranoproliferative glomerulonephritis
  Yoshio Tani; Hiroshi Kida; Toshio Abe; Naohisa Tomosugi; Yafumi Saito; Teruo Asamoto; Yoshitaka Koshino; Hitoshi Yokoyama; Mitsuhiro Yoshimura; Nobu Hattori
  The Japanese Journal of Nephrology, 26, 10, 1337, 1344, 1984, [Peer-reviewed]
  English, Scientific journal
• Renal pathology in fulminant hepatitis : Tubulointerstitial lesions accompanied with multinucleated giant cells
  Hitoshi Yokoyama; Hiroshi Kida; Mitsuhiro Yoshimura; Yoshitaka Koshino; Teruo Asamoto; Yafumi Saito; Naohisa Tomosugi; Toshio Abe; Nobu Hattori
  The Japanese Journal of Nephrology, 26, 11, 1479, 1485, 1984, [Peer-reviewed]
  English, Scientific journal
• Mesangiolysis in diabetic glomerulosclerosis
  Yafumi Saito; Hiroshi Kida; Mitsuhiro Yoshimura; Hitoshi Yokoyama; Yoshitaka Koshino; Teruo Asamoto; Naohisa Tomosugi; Toshio Abe; Nobu Hattori
  The Japanese Journal of Nephrology, 26, 4, 367, 375, 1984, [Peer-reviewed]
  English, Scientific journal
• Human influenza virus infection in mink: serological evidence of infection in summer and autumn.
  Okazaki K; Yanagawa R; Kida H; Noda H
  Veterinary microbiology, 8, 251, 257, 3, Jun. 1983, [Peer-reviewed]
• INHIBITION OF VIRUS-INDUCED HEMOLYSIS WITH MONOCLONAL-ANTIBODIES TO DIFFERENT ANTIGENIC AREAS ON THE HEMAGGLUTININ MOLECULE OF A SEAL MASSACHUSETTS 1/80 (H7N7) INFLUENZA-VIRUS
  H KIDA; RG WEBSTER; R YANAGAWA
  ARCHIVES OF VIROLOGY, 76, 2, 91, 99, 1983, [Peer-reviewed]
  English, Scientific journal
• Contact infection of mink with 5 subtypes of avian influenza virus. Brief report.
  Okazaki K; Yanagawa R; Kida H
  Archives of virology, 77, 265, 269, 2-4, 1983, [Peer-reviewed]
• Presence of Vi antigen in a virulent strain of Leptospira interrogans serovar pomona and relation of Vi antigens of leptospiras to resistance to leptospiricidal activity mediated by antiserum plus complement
  K. Ueno; R. Yanagawa; H. Kida
  Zentralblatt fur Bakteriologie Mikrobiologie und Hygiene - Abt. 1 Orig. A, 252, 4, 557, 565, 1982, [Peer-reviewed]
  English, Scientific journal
• The Clinical Significance of Crescents in Idiopathic Mesangial Proliferative Glomerulonephritis
  Toshio Abe; Hiroshi Kida; Hitoshi Yokoyama; Yoshitaka Eoshino; Teruo Asamoto; Yafumi Saito; Yoshio Tani; Naohisa Tomosugi; Nobu Hattori
  The Japanese Journal of Nephrology, 24, 9, 987, 995, 1982, [Peer-reviewed]
  English, Scientific journal
• BIOLOGICAL-ACTIVITY OF MONOCLONAL-ANTIBODIES TO OPERATIONALLY DEFINED ANTIGENIC REGIONS ON THE HEMAGGLUTININ MOLECULE OF A/SEAL MASSACHUSETTS/1/80 (H7N7) INFLUENZA-VIRUS
  H KIDA; LE BROWN; RG WEBSTER
  VIROLOGY, 122, 1, 38, 47, 1982, [Peer-reviewed]
  English, Scientific journal
• PRESENCE OF VI ANTIGEN IN A VIRULENT-STRAIN OF LEPTOSPIRA INTERROGANS SEROVAR POMONA AND RELATION OF VI ANTIGENS OF LEPTOSPIRAS TO RESISTANCE TO LEPTOSPIRICIDAL ACTIVITY MEDIATED BY ANTISERUM PLUS COMPLEMENT
  K UENO; R YANAGAWA; H KIDA
  ZENTRALBLATT FUR BAKTERIOLOGIE MIKROBIOLOGIE UND HYGIENE SERIES A-MEDICAL MICROBIOLOGY INFECTIOUS DISEASES VIROLOGY PARASITOLOGY, 252, 4, 557, 565, 1982, [Peer-reviewed]
  English, Scientific journal
• Membranoproliferative Glomerulonephritis and Allied Glomerulonephritis
  Kazuhiro Dohi; Yasushi Nakamoto; Hiroshi Kida; Toshio Abe; Masahiko Fujioka; Nobu Hattori
  The Japanese Journal of Nephrology, 23, 2, 195, 207, 1981, [Peer-reviewed]
  English, Scientific journal
• SURVEY OF INFLUENZA-VIRUSES IN FERAL BIRDS IN 1979 AND ISOLATION OF A STRAIN POSSESSING HAV6NAV5 FROM CLOACA OF AN EASTERN DUNLIN
  E HONDA; H KIDA; R YANAGAWA; Y MATSUURA; K YAGYU; M TSUJI; K UENO; N YAMAUCHI; S MISHIMA; H OGI; K SHIMAZAKI
  JAPANESE JOURNAL OF VETERINARY RESEARCH, 29, 3-4, 83, 87, 1981, [Peer-reviewed]
  English, Scientific journal
• GROWTH OF AVIAN AND HUMAN INFLUENZA-VIRUSES IN ORGAN-CULTURES OF DUCK AND CHICKEN COLONS
  C OHTA; R YANAGAWA; H KIDA
  ARCHIVES OF VIROLOGY, 70, 2, 137, 145, 1981, [Peer-reviewed]
  English, Scientific journal
• CLASSIFICATION OF AVIAN PARAMYXOVIRUSES BY IMMUNODIFFUSION ON THE BASIS OF ANTIGENIC SPECIFICITY OF THEIR M-PROTEIN ANTIGENS
  H KIDA; R YANAGAWA
  JOURNAL OF GENERAL VIROLOGY, 52, JAN, 103, 111, 1981, [Peer-reviewed]
  English, Scientific journal
• DUCK INFLUENZA LACKING EVIDENCE OF DISEASE SIGNS AND IMMUNE-RESPONSE
  H KIDA; R YANAGAWA; Y MATSUOKA
  INFECTION AND IMMUNITY, 30, 2, 547, 553, 1980, [Peer-reviewed]
  English, Scientific journal

• 宿主免疫応答における酸化LDL受容体LOX-1の役割
  大野 円実; Obeng-Kyeremeh Richard; 市居 修; 川原 麻弥子; 治田 みのり; 関屋 俊輝; Handabile Chimuka; 野村 直樹; 河喜多 智美; 輿石 雄一; 垣野 明美; 沢村 達也; 新開 大史; 喜田 宏, 臨床とウイルス, 53, 3, 210, 210, Sep. 2025
  日本臨床ウイルス学会, Japanese
• Analysis of cell surface glycan structures affecting proliferation of avian influenza viruses
  前川明博; 日尾野隆大; 日尾野隆大; 迫田義博; 迫田義博; 喜田宏; 栂谷内晶; 栂谷内晶; 西原祥子; 西原祥子; 高瀬明; 高瀬明, 日本ウイルス学会学術集会プログラム・予稿集(Web), 72nd, 2025
• インフルエンザAウイルスのヘマグルチニンに対する高親和性及び低親和性細胞の作製
  前川明博; 日尾野隆大; 迫田義博; 喜田宏; 栂谷内晶; 栂谷内晶; 西原祥子; 西原祥子; 高瀬明; 高瀬明, 日本分子生物学会年会プログラム・要旨集(Web), 47th, 2024
• Elucidation of the glycan structure that contributes to bind of influenza A virus using glycan engineered cells.
  前川明博; 日尾野隆大; 迫田義博; 喜田宏; 栂谷内晶; 栂谷内晶; 西原祥子; 西原祥子; 高瀬明; 高瀬明, 日本ウイルス学会学術集会プログラム・予稿集(Web), 71st, 2024
• Single particle analysis of A/Singapore/GP1908/2015 (H1N1) influenza virus hemagglutinin
  小林颯太; 関屋俊輝; 喜多俊介; 新開大史; 喜田宏; 前仲勝実; 前仲勝実; 前仲勝実; 前仲勝実, 日本生体防御学会学術総会講演抄録集, 35th (Web), 2024
• 霊長類モデルを用いたインフルエンザとCOVID-19のワクチン開発
  伊藤靖; 石垣宏仁; 仲山美沙子; NGUYEN Thanh Cong; 北川善紀; 安井文彦; 小原道法; 石井健; 新開大史; 迫田義博; 喜田宏, 日本実験動物学会総会講演要旨集(Web), 69th, 2022
• Selecting and using the appropriate influenza vaccine for each individual
  Toshiki Sekiya; Marumi Ohno; Naoki Nomura; Chimuka Handabile; Masashi Shingai; David C. Jackson; Lorena E. Brown; Hiroshi Kida, Viruses, 13, 6, Jun. 2021
  Book review
• Human H1N1 influenza A viruses utilize sulfated glycans containing α2,3-linked sialic acid expressed on the membranes of chicken embryos as receptors
  高瀬明; 高瀬明; 一宮智美; 岡松正敏; 木下貴明; 木下貴明; 小林大樹; 市居修; 市居修; 山本直樹; 山本直樹; 迫田義博; 迫田義博; 喜田宏; 川島博人; 山本一夫; 西原祥子; 西原祥子, 日本ウイルス学会学術集会プログラム・予稿集(Web), 68th, 2021
• 2020年度冬季に東日本の野鳥から分離された高病原性鳥インフルエンザウイルスの性状
  磯田典和; 磯田典和; 日尾野隆大; TWABELA Augustin T.; BAZARRAGCHAA Enkhbold; KIEN Le Trung; LOC Huynh Tan; 小笠原浩平; 林裕貴; 渡辺有希子; 齊藤慶輔; 喜田宏; 迫田義博; 迫田義博, 日本獣医学会学術集会講演要旨集, 164th (CD-ROM), 2021
• インフルエンザウイルスライブラリーを活用したパンデミックインフルエンザ対策
  野村直樹; 新開大史; 松野啓太; 関屋俊輝; 関屋俊輝; 大野円実; 磯田典和; 迫田義博; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 164th (CD-ROM), 2021
• Receptor structures that contribute to the propagation of human H1N1 influenza A viruses in embryonated chicken eggs
  高瀬明; 高瀬明; 一宮智美; 岡松正敏; 木下貴明; 木下貴明; 小林大樹; 市居修; 山本直樹; 山本直樹; 迫田義博; 迫田義博; 喜田宏; 川島博人; 山本一夫; 西原祥子; 西原祥子, 日本糖質学会年会要旨集, 40th, 2021
• 座談会 バロキサビル マルボキシルの是非
  喜田 宏; 河岡 義裕; 齋藤 玲子; 高下 恵美, インフルエンザ = Infuruenza : その他の呼吸器感染症 / 「インフルエンザ-その他の呼吸器感染症」編集委員会 編, 20, 4, 179, 185, Dec. 2019
  東京 : メディカルレビュー社, Japanese
• 豚コレラウイルスワクチン株感染による細胞死誘導と細胞変性効果
  板倉友香里; 板倉友香里; 松野啓太; 松野啓太; 伊藤麻子; 藤本悠理; 田村友和; 亀山健一郎; 岡松正敏; NICOLAS Ruggli; NICOLAS Ruggli; 喜田宏; 喜田宏; 澤洋文; 澤洋文; 迫田義博; 迫田義博, 日本ウイルス学会学術集会プログラム・予稿集(Web), 67th, 2019
• バロキサビル マルボキシル
  河野 茂; 齋藤 玲子; 渡辺 彰; 菅谷 憲夫; 喜田 宏; 三鴨 廣繁, 感染症学雑誌, 93, 1, 64, 65, Jan. 2019
  (一社)日本感染症学会, Japanese
• バロキサビル マルボキシル
  河野 茂; 齋藤 玲子; 渡辺 彰; 菅谷 憲夫; 喜田 宏; 三鴨 廣繁, 日本化学療法学会雑誌, 67, 1, 112, 113, Jan. 2019
  (公社)日本化学療法学会, Japanese
• 海外から持ち込まれた未加熱家きん肉等から分離された高病原性及び低病原性H7N9亜型鳥インフルエンザウイルスの性状解析
  柴田明弘; 岡松正敏; 住吉理穂; 松野啓太; 松野啓太; WANG Zu‐Jyun; WANG Zu‐Jyun; 喜田宏; 喜田宏; 尾坂優之; 迫田義博; 迫田義博, 日本獣医学会学術集会講演要旨集, 161st, 355, 21 Aug. 2018
  Japanese
• 2014-2017のベトナムにおけるH5高病原性鳥インフルエンザ発生の時空間・リスク解析(Spatiotemporal and risk analysis of H5 highly pathogenic avian influenza occurrence in Vietnam during 2014-2017)
  Nguyen Thanh-Lam; Stevenson Mark; Firestone Simon; Sims Les; Chu Huy; Nguyen Long; Nguyen Tien; 磯田 典和; 松野 啓太; 岡松 正敏; 喜田 宏; 迫田 義博, 日本獣医学会学術集会講演要旨集, 161回, 357, 357, Aug. 2018
  (公社)日本獣医学会, English
• 鳥インフルエンザウイルス検出におけるAlere i influenza A&Bの評価(Evaluation of Alere i influenza A&B for the detection of avian influenza virus)
  Enkhbold Bazarragchaa; 岡松 正敏; Ulaankhuu Ankhanbaatar; 松野 啓太; 喜田 宏; 新井 宏育; 迫田 義博, 日本獣医学会学術集会講演要旨集, 161回, 357, 357, Aug. 2018
  (公社)日本獣医学会, English
• 不活化インフルエンザウイルス全粒子ワクチンの非臨床試験
  新開大史; 新開大史; 野村直樹; 関屋俊輝; 関屋俊輝; 大野円実; 笹田万友美; 大東卓史; 鈴木紗織; 石垣宏仁; 伊藤靖; 小笠原一誠; 小笠原一誠; 喜田宏; 喜田宏; 喜田宏, 日本ワクチン学会学術集会プログラム・抄録集, 22nd, 99, 2018
  Japanese
• サルモデルを用いた季節性インフルエンザに対する不活化全粒子ワクチンの有効性評価
  伊藤靖; 鈴木紗織; 石垣宏仁; 仲山美沙子; 新開大史; 新開大史; 大東卓史; 野村直樹; 喜田宏; 喜田宏; 喜田宏; 小笠原一誠; 小笠原一誠, 日本ワクチン学会学術集会プログラム・抄録集, 22nd, 99, 2018
  Japanese
• H5N1高病原性鳥インフルエンザウイルスのシアル酸非依存的な細胞侵入経路の解析
  梶原 直樹; 野村 奈美子; 宇梶 麻紗子; 貞任 大地; 山本 直樹; 小原 道法; 安井 文彦; 迫田 義博; 喜田 宏; 芝崎 太, 生命科学系学会合同年次大会, 2017年度, [2P, 0957], Dec. 2017
  生命科学系学会合同年次大会運営事務局, Japanese
• H5N1高病原性鳥インフルエンザウイルスのシアル酸非依存的な細胞侵入経路の解析
  梶原 直樹; 野村 奈美子; 宇梶 麻紗子; 貞任 大地; 山本 直樹; 小原 道法; 安井 文彦; 迫田 義博; 喜田 宏; 芝崎 太, 生命科学系学会合同年次大会, 2017年度, [2P, 0957], Dec. 2017
  生命科学系学会合同年次大会運営事務局, Japanese
• 高病原性鳥インフルエンザウイルスの進化―H5ウイルスを中心に―
  迫田義博; 迫田義博; 喜田宏; 喜田宏, 感染症, 47, 6, 189‐199, 199, 20 Nov. 2017
  アステラス製薬(株), Japanese
• 鳥インフルエンザとパンデミックインフルエンザの要
  喜田 宏, 医薬ジャーナル, 53, 10, 111, 115, Oct. 2017
• 2.3.4.4高病原性鳥インフルエンザウイルスに対する新規モノクローナル抗体を用いた免疫クロマトグラフィーキットによるH5ヘマグルチニンの迅速かつ広範囲検出(Rapid and broad detection of H5 hemagglutinin by an immunochromatographic kit using novel monoclonal antibody against a 2.3.4.4 highly pathogenic avian influenza virus)
  Nguyen Thanh-Lam; 中石 和成; 本島 桂子; 大河原 彩子; 日尾野 隆大; 松野 啓太; 岡松 正敏; 高田 礼人; 喜田 宏; 迫田 義博, 日本獣医学会学術集会講演要旨集, 160回, 384, 384, Aug. 2017
  (公社)日本獣医学会, English
• Rapid and broad detection of H5 hemagglutinin by an immunochromatographic kit using novel monoclonal antibody against a 2.3.4.4 highly pathogenic avian influenza virus(和訳中)
  Nguyen Thanh-Lam; 中石 和成; 本島 桂子; 大河原 彩子; 日尾野 隆大; 松野 啓太; 岡松 正敏; 高田 礼人; 喜田 宏; 迫田 義博, 日本獣医学会学術集会講演要旨集, 160回, 384, 384, Aug. 2017
  (公社)日本獣医学会, English
• インフルエンザ罹患患児経過中の監護者における特異的免疫反応経時推移
  熊谷卓司; 中山哲夫; 奥野良信; 森川佐依子; 加瀬哲男; 纐纈律子; 吉井洋紀; 本條健太; 迫田義博; 喜田宏; 庵原俊昭, 日本小児感染症学会総会・学術集会プログラム・抄録集, 49th, 136, 2017
  Japanese
• ワクチン接種後の鶏におけるH5鳥インフルエンザウイルスの抗原多様性の選択(Selection of antigenic variants of H5 avian influenza viruses in vaccinated chickens)
  Nguyen Thanh-Lam; 西 達也; 七戸 新太郎; Chu Duc-Huy; 日尾野 隆大; 松野 啓太; 岡松 正敏; 喜田 宏; 迫田 義博, 日本獣医学会学術集会講演要旨集, 159回, 371, 371, Aug. 2016
  (公社)日本獣医学会, English
• 新たなインフルエンザウイルスの出現と季節性インフルエンザワクチン
  喜田 宏, 32, 6, 57, 64, May 2016
• 鳥インフルエンザとパンデミックインフルエンザ
  喜田 宏, 感染症 最新の治療 2016-2018, 10, 13, Apr. 2016
• 鳥，パンデミックと季節性インフルエンザをどうする
  喜田 宏, 養鶏の友, 648, 14, 19, Feb. 2016
  日本畜産振興会, Japanese
• 実地医療に役立つインフルエンザトピックス(第13回)人獣共通感染症とインフルエンザ
  喜田 宏, インフルエンザ, 17, 1, 15, 21, Jan. 2016
  メディカルレビュー社, Japanese
• インフルエンザ患児の家族内被暴露監護者における血清抗体ならびに細胞性免疫反応経時推移
  熊谷卓司; 中山哲夫; 奥野良信; 加瀬哲男; 森川佐依子; 迫田義博; 迫田義博; 喜田宏; 管秀; 庵原俊昭, 日本ワクチン学会学術集会プログラム・抄録集, 20th, 83, 2016
  Japanese
• インフルエンザワクチンの将来展望 (特集 成人の予防接種はどうあるべきか? : 予防医療推進の観点から) -- (成人予防接種の注意点と将来展望)
  喜田 宏, 診断と治療, 103, 11, 1500, 1505, Nov. 2015
  診断と治療社, Japanese
• 鳥，パンデミックと季節性インフルエンザをどうする
  喜田 宏, 畜産技術, 727, 37-43, Nov. 2015
• インフルエンザワクチンの将来展望
  喜田 宏, 診断と治療, 103, 11, 1500, 1505, Nov. 2015
• 鳥インフルエンザの問題点 : A(H5N1)とA(H7N9)を中心に (創刊50周年記念号) -- (特集 インフルエンザの最新事情とその対策 : One Healthの観点から)
  喜田 宏, 医薬ジャーナル, 51, 10, 151, 154, Oct. 2015
  医薬ジャーナル社, Japanese
• 鳥インフルエンザの問題点 ～A(H5N1)とA(H7N9)を中心に～
  喜田 宏, 医薬ジャーナル, 51, 10, 2401, 2404, Oct. 2015
• 近年アジア地域で分離された鳥インフルエンザウイルスのアヒル,スズメ,カラス,およびクマネズミに対する病原性
  小笠原浩平; 岡松正敏; 日尾野隆大; 七戸新太郎; 栗林沙弥; 市川貴也; 西達也; CHU Duc‐Huy; 鈴木瑞穂; 遠藤真由美; 田中和之; 谷川力; 喜田宏; 喜田宏; 喜田宏; 迫田義博; 迫田義博; 迫田義博, 日本獣医学会学術集会講演要旨集, 158th, 333, 333, 30 Aug. 2015
  (公社)日本獣医学会, Japanese
• インフルエンザウイルスのフコシル化α2,3シアロ糖認識機構の解析
  日尾野隆大; 岡松正敏; 五十嵐学; 五十嵐学; MCBRIDE Ryan; DE VIRES Robert; PAULSON James; 松野啓太; 松野啓太; 迫田義博; 迫田義博; 喜田宏; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 158th, 332, 30 Aug. 2015
  Japanese
• 2014年のベトナムにおける介入有りまたは介入なしの生鳥市場にて単離された鳥インフルエンザウイルスの性状解析(Characterization of avian influenza viruses isolated in live bird markets with and without intervention in Vietnam in 2014)
  Chu Duc-Huy; 岡松 正敏; 松野 啓太; 日尾野 隆大; 小笠原 浩平; 鈴木 瑞穂; Nguyen Thanh Lam; 喜田 宏; 迫田 義博, 日本獣医学会学術集会講演要旨集, 158回, 329, 329, Aug. 2015
  (公社)日本獣医学会, English
• インフルエンザウイルスのフコシル化α2,3シアロ糖認識機構の解析
  日尾野隆大; 岡松正敏; 五十嵐学; 五十嵐学; MCBRIDE Ryan; DE VIRES Robert P; PAULSON James C; 迫田義博; 迫田義博; 喜田宏; 喜田宏, 日本糖質学会年会要旨集, 34th, 173, 01 Jul. 2015
  Japanese
• 鳥インフルエンザウイルスはパンデミックを起こすか？
  喜田 宏, 臨床と微生物, 42, 3, 249, 254, May 2015
• 全粒子ワクチンは複数のクレードのH5N1高病原性鳥インフルエンザウイルスに対する記憶免疫反応を誘導する
  仲山 美沙子; 七戸 新太郎; 伊藤 靖; 石垣 宏仁; 北野 光崇; 有方 雅彦; Pham Van Loi; 石田 英晃; 北川 直子; 小笠原 一誠; 土屋 英明; 中村 紳一朗; 岡松 正敏; 迫田 義博; 市川 貴也; 喜田 宏; Le Quynh Mai; 伊藤 睦美; 河岡 義裕, 滋賀医学, 37, 146, 146, Mar. 2015
  (一社)滋賀県医師会, Japanese
• カニクイザルを用いたライブラリー由来全粒子不活化ワクチンのH7N9亜型インフルエンザウイルスに対する有効性
  伊藤靖; 七戸新太郎; 仲山美沙子; 石垣宏仁; 岡松正敏; 迫田義博; 喜田宏; 小笠原一誠, 日本ワクチン学会学術集会プログラム・抄録集, 19th, 2015
• ヒトH1インフルエンザウイルスは6硫酸化糖鎖構造をレセプターとするか?
  一宮智美; 高瀬明; 木下聖子; 喜田宏; 西原祥子, 日本糖質学会年会要旨集, 34th, 2015
• 北海道大学人獣共通感染症リサーチセンターザンビア拠点における感染症対策への取り組み
  小川寛人; 喜田宏, 最新医学, 2015
• Present and future seasonal influenza vacines
  Hiroshi KIDA, 化学療法の領域, 30, 12, 84, 89, Dec. 2014
• Update information of outbreaks of highly and low pathogenic avian influenza in poultry and wild birds
  Masatoshi OKAMATSU; Yoshihiro SAKODA; Hiroshi KIDA, 化学療法の領域, 30, 12, 25, 32, Dec. 2014
• インフルエンザの最新知見~鳥,パンデミックと季節性インフルエンザ対策をどうするか~1.日本および世界各地における高病原性および低病原性鳥インフルエンザウイルスの家禽および野鳥における感染状況
  岡松正敏; 迫田義博; 喜田宏, 化学療法の領域, 30, 12, 2173, 2180, 25 Nov. 2014
  Japanese
• 豚コレラウイルス非構造蛋白NS4BのN末端両親媒性ヘリックスは豚に対する病原性に関与する
  田村友和; RUGGLI Nicolas; LINGER Matthias; 長島尚史; 峯淳貴; 岡松正敏; HOFMANN Martin A; SUMMERFIELD Artur; 喜田宏; 迫田義博, 日本ウイルス学会学術集会プログラム・抄録集, 62nd, 250, 31 Oct. 2014
  Japanese
• 鳥インフルエンザウイルスのヒト型レセプター特異性獲得メカニズムの解析
  柳田里澄; 岡松正敏; 日尾野隆大; 迫田義博; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 62nd, 155, 31 Oct. 2014
  Japanese
• H5N1高病原性鳥インフルエンザ組換えワクシニアワクチン単回接種による免疫長期持続作用機序の解析
  安井文彦; 宗片圭祐; 倉石武; 服部正策; 藤幸知子; 米田美佐子; 迫田義博; 喜田宏; 甲斐知恵子; 小原道法, 日本ウイルス学会学術集会プログラム・抄録集, 62nd, 235, 31 Oct. 2014
  Japanese
• H5N1高病原性鳥インフルエンザウイルスがブタに感染するとSAα2,6Galレセプターに結合するウイルスが選択されるか?
  七戸新太郎; 迫田義博; 西達也; 日尾野隆大; 岡松正敏; 伊藤靖; 小笠原一誠; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 62nd, 154, 31 Oct. 2014
  Japanese
• 2010年から2014年に家禽及び野鳥から分離されたH5及びH7鳥インフルエンザウイルスの遺伝子と抗原性の解析
  迫田義博; 大河原彩子; 日尾野隆大; 小笠原浩平; 岡松正敏; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 62nd, 163, 31 Oct. 2014
  Japanese
• ニワトリのインフルエンザウイルスはフコシル化および硫酸化α2,3シアル酸糖鎖をレセプターとする
  岡松正敏; 日尾野隆大; 五十嵐学; DE VRIES Robert; 西原祥子; 高瀬明; PAULSON James C; 迫田義博; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 62nd, 154, 31 Oct. 2014
  Japanese
• H5N1インフルエンザウイルスに対する中和抗体を用いた受動免疫の感染防御効果
  吉田玲子; 伊藤靖; 七戸新太郎; 小笠原一誠; 日尾野隆大; 岡松正敏; 迫田義博; 喜田宏; LE Mai Quynh; 河岡義裕; 五十嵐学; 鈴木定彦; 高田礼人, 日本ウイルス学会学術集会プログラム・抄録集, 62nd, 234, 31 Oct. 2014
  Japanese
• Research activities of Hokudai center for Zoonosis Control in Zambia
  Hideaki Higashi; Hiroshi Kida, Journal of Disaster Research, 9, 5, 818, 822, 01 Oct. 2014
  Fuji Technology Press, English, Book review
• 鳥インフルエンザの現状と今後
  喜田 宏, 医薬ジャーナル, 50, 10, 107, 112, Oct. 2014
• 牛ウイルス性下痢ウイルス準種のcDNAクローン構築と自然免疫制御能の解析
  SHIOKAWA MAI; KATO AYANO; FUJIMOTO YURI; ABE YURI; TAMURA TOMOKAZU; NISHINE KAORU; MINE JUNKI; AOKI HIROSHI; FUKUSHO AKIO; KIDA HIROSHI; SAKODA YOSHIHIRO, 日本獣医学会学術集会講演要旨集, 157th, 396, 396, 11 Aug. 2014
  (公社)日本獣医学会, Japanese
• 2010年から2013年に家禽及び野鳥から分離されたH5及びH7鳥インフルエンザウイルスの遺伝子と抗原性の解析
  大河原彩子; 日尾野隆大; 小笠原浩平; 岡松正敏; 迫田義博; 喜田宏, 日本獣医学会学術集会講演要旨集, 157th, 411, 11 Aug. 2014
  Japanese
• 糖鎖アレイを用いたカモとニワトリのインフルエンザウイルスのレセプター特異性
  岡松正敏; DE VRIES Robert; 日尾野隆大; 迫田義博; PAULSON C James; 喜田宏, 日本獣医学会学術集会講演要旨集, 157th, 419, 11 Aug. 2014
  Japanese
• 豚コレラウイルス非構造蛋白NS4BのN末端領域は豚に対する病原性に関与する
  田村友和; RUGGLI Nicolas; 長島尚史; 峯淳貴; 岡松正敏; SUMMERFIELD Artur; HOFMANN Martin A; 喜田宏; 迫田義博, 日本獣医学会学術集会講演要旨集, 157th, 410, 11 Aug. 2014
  Japanese
• ニワトリのインフルエンザウイルスはフコシル化α2,3シアル酸糖鎖をレセプターとする
  日尾野隆大; 岡松正敏; 五十嵐学; 西原祥子; 高瀬明; 迫田義博; 喜田宏, 日本糖質学会年会要旨集, 33rd, 62, 23 Jul. 2014
  Japanese
• 不活化全粒子インフルエンザワクチンを内包したマイクロニードルアレイによる免疫誘導特性の評価
  小山田孝嘉; 来馬浩二; 島田俊雄; 迫田義博; 喜田宏, 日本DDS学会学術集会プログラム予稿集, 30th, 184, 01 Jul. 2014
  Japanese
• ワクチン研究者に聞く
  喜田 宏, ワクチンジャーナル, 2, 1, 40, 44, Jun. 2014
• 感染症研究国際ネットワーク研究の現状 7.ザンビア‐北海道大学人獣共通感染症リサーチセンターザンビア拠点
  東秀明; 東秀明; 喜田宏, 化学療法の領域, 30, 6, 1234, 1239, 25 May 2014
  Japanese
• 私のインフルエンザ研究
  喜田宏; 喜田宏; 喜田宏; 喜田宏, 臨床とウイルス, 42, 2, S6-S7, 01 May 2014
  Japanese
• 次世代型感染症ワクチン 今,インフルエンザワクチンに何が求められるか
  喜田宏; 喜田宏; 喜田宏; 喜田宏; 喜田宏, 最新医学, 69, 4, 858, 864, 10 Apr. 2014
  最新医学社, Japanese
• カニクイザルにおける2013年H7N9亜型インフルエンザウイルスに対するワクチンとNA阻害剤の効果
  伊藤靖; 仲山美沙子; 石垣宏仁; 石田英晃; 七戸新太郎; 岡松正敏; 迫田義博; 喜田宏; 喜田宏; 小笠原一誠, 日本病理学会会誌, 103, 1, 224, 26 Mar. 2014
  Japanese
• 免疫低下状態のカニクイザルにおけるH1N1亜型インフルエンザウイルスの病原性の解析
  伊藤靖; LOI Pham Van; 仲山美沙子; 石垣宏仁; 有方雅彦; 石田英晃; 北川直子; 小笠原一誠; 七戸新太郎; 岡松正敏; 迫田義博; 喜田宏; 喜田宏, 滋賀医学, 36, 142, 20 Mar. 2014
  Japanese
• どうする?鳥インフルエンザとパンデミックインフルエンザ
  喜田宏; 喜田宏, 日本環境感染学会誌, 29, Supplement, 137, 24 Jan. 2014
  Japanese
• 鳥インフルエンザウイルスの病原性と感染対策
  喜田宏; 喜田宏, 感染症, 44, 1, 13-18,9, 20 Jan. 2014
  Japanese
• 豚コレラウイルスALD/A76株の病原性解析に用いる完全長cDNAクローンおよびレプリコンの作出
  藤本悠理; 田村友和; 遠藤真由美; 吉野史; RUGGLI Nicolas; 喜田宏; 喜田宏; 迫田義博, 日本獣医学会学術集会講演要旨集, 157th, 2014
• 鳥インフルエンザ
  喜田宏; 喜田宏; 喜田宏; 喜田宏, 感染症内科, 1, 6, 564, 572, 28 Dec. 2013
  Japanese
• グローバル化する感染症の最新情報 ウイルス感染症 インフルエンザ
  喜田宏, 月刊臨床と研究, 90, 12, 1666, 1673, 20 Dec. 2013
  大道学館出版部, Japanese
• 微生物ABC インフルエンザウイルス
  喜田宏, Up-to-date子どもの感染症, 1, 2, 74, 81, 10 Dec. 2013
  メディカルレビュー社, Japanese
• 人獣共通感染症としてのインフルエンザ
  喜田宏, 月刊養豚界, 48, 11, 20, 24, 01 Nov. 2013
  緑書房, Japanese
• クローズアップ インフルエンザ インフルエンザウイルスの生態
  喜田宏, 小児内科, 45, 11, 1927, 1934, 01 Nov. 2013
  Japanese
• GANPトランスジェニックマウスを用いたH5N1高病原性鳥インフルエンザウイルスHAに対する汎クレード高親和性中和単クローン抗体の開発
  安井文彦; 桑原一彦; 飛田良美; 棟方翼; 斉藤誠; 七戸新太郎; 迫田義博; 喜田宏; 阪口薫雄; 小原道法, 日本ウイルス学会学術集会プログラム・抄録集, 61st, 153, 29 Oct. 2013
  Japanese
• 糖鎖アレイデータベースから抽出されたインフルエンザウイルス感染を増強する糖鎖構造
  一宮智美; 西原祥子; 木下聖子; 山本直樹; 喜田宏; 高瀬明, 日本ウイルス学会学術集会プログラム・抄録集, 61st, 239, 29 Oct. 2013
  Japanese
• 2010年に稚内で分離された2株の高病原性鳥インフルエンザウイルスの病原性比較
  直亨則; 梶原将大; 丸山隼輝; 木村享史; MANZOOR Rashid; 村松美笑子; 岡松正敏; 宮本洋子; 吉田玲子; 迫田義博; 喜田宏; 高田礼人, 日本ウイルス学会学術集会プログラム・抄録集, 61st, 150, 29 Oct. 2013
  Japanese
• 高病原性鳥インフルエンザ抗原タンパク質発現組換え麻疹ウイルスのサル感染モデルにおける防御効果の検討
  藤幸知子; 米田美佐子; 堀江亮; 倉石武; 池田房子; 石井美穂; 小見美央; 安井文彦; 宗片圭祐; 佐藤宏樹; 服部正策; 喜田宏; 小原道法; 甲斐知恵子, 日本ウイルス学会学術集会プログラム・抄録集, 61st, 155, 29 Oct. 2013
  Japanese
• 計算科学手法を用いたインフルエンザウイルスヘマグルチニンと亜型間交差反応性抗体との分子間相互作用の解析
  五十嵐学; 吉田玲子; 関嶋政和; 常盤広明; 喜田宏; 伊藤公人; 高田礼人, 日本ウイルス学会学術集会プログラム・抄録集, 61st, 239, 29 Oct. 2013
  Japanese
• ウイルス学の立場から―鳥インフルエンザとパンデミックインフルエンザ対策の基本―
  喜田宏, 感染症道場, 2, 4, 59, 61, 20 Oct. 2013
  Japanese
• Influenza virus-like particles containing HA, NA, and M1 induced protection in chickens against a lethal challenge with the highly pathogenic H5N1 avian influenza virus
  Motofumi Shimizu; Satomi Yanase; O. O. Chang Myint; Masatoshi Okamatsu; Yoshihiro Sakoda; Hiroshi Kida; Hiroshi Takaku; Hiroshi Takaku, Journal of Vaccines and Vaccination, 4, 04 Oct. 2013
• これからのインフルエンザ診療―的確な診断・適正な治療・先手の予防 H7N9およびH5N1鳥インフルエンザウイルスについて
  喜田宏, 感染と抗菌薬, 16, 3, 272, 277, 10 Sep. 2013
  ヴァンメディカル, Japanese
• H7N9およびH5N1鳥インフルエンザウイルスについて (特集 これからのインフルエンザ診療 : 的確な診断・適正な治療・先手の予防)
  喜田 宏, 感染と抗菌薬, 16, 3, 272, 277, Sep. 2013
  ヴァンメディカル, Japanese
• 抗PB2細胞内発現単クローン抗体のA型インフルエンザウイルスに対する感染抵抗性
  藤本佳万; 尾崎絹代; 前田雅弘; 西島謙一; 高桑弘樹; 大槻公一; 喜田宏; 小野悦郎, 日本獣医学会学術集会講演要旨集, 156th, 270, 30 Aug. 2013
  Japanese
• 牛ウイルス性下痢ウイルスのcDNAクローンの作出と自然免疫抑制機能の解析
  安部優里; 迫田義博; 三津橋和也; 田村友和; 小佐々隆志; 中村成幸; 喜田宏, 日本獣医学会学術集会講演要旨集, 156th, 265, 30 Aug. 2013
  Japanese
• H7低病原性鳥インフルエンザウイルスのニワトリに対する病原性獲得メカニズム
  市川貴也; 岡松正敏; 佐藤由佳; 日尾野隆大; 迫田義博; 喜田宏, 日本獣医学会学術集会講演要旨集, 156th, 269, 30 Aug. 2013
  Japanese
• Unmasking of the Nature of Avian Influenza for the Successful Control
  喜田 宏, 日本食品科学工学会誌 = Journal of the Japanese Society for Food Science and Technology, 60, 7, 371, 374, Jul. 2013
  日本食品科学工学会, Japanese
• 鳥インフルエンザの現状と対策
  岡松正敏; 喜田宏, 日本獣医師会雑誌, 66, 6, 352, 354, 20 Jun. 2013
  日本獣医師会, Japanese
• ニワトリのインフルエンザウイルスはニワトリ気管上皮に発現するフコシル化α2,3シアル酸糖鎖をレセプターとして認識する
  日尾野隆大; 岡松正敏; 西原祥子; 高瀬明; 迫田義博; 喜田宏, 日本獣医学会学術集会講演要旨集, 155th, 229, 04 Mar. 2013
  Japanese
• 鳥インフルエンザウイルスがブタに感染するとSAα2,6Galレセプターを認識するウイルスが選択される
  七戸新太郎; 岡松正敏; 迫田義博; 喜田宏, 日本獣医学会学術集会講演要旨集, 155th, 229, 04 Mar. 2013
  Japanese
• タイで分離されたEND陰性豚コレラウイルスの遺伝子と病原性の解析
  迫田義博; 三津橋和也; 田村友和; 長島尚史; 岡松正敏; NICOLAS Ruggli; SUGIRA Parchariyanon; WASANA Pinyochon; 喜田宏, 日本獣医学会学術集会講演要旨集, 155th, 226, 04 Mar. 2013
  Japanese
• 高病原性鳥インフルエンザとパンデミックインフルエンザ
  喜田宏, 感染症道場, 2, 1, 30, 33, 20 Jan. 2013
  メディカルレビュー社, Japanese
• ワクチニアウイルスDIs株を母体としたインフルエンザHA組換えワクチンの混合接種によるカニクイザルでの発症防御効果
  宗片圭祐; 安井文彦; 伊藤靖; 石井孝司; 七戸新太郎; 喜田宏; 小笠原一誠; 小原道法, 日本ワクチン学会学術集会プログラム・抄録集, 17th, 160, 2013
  Japanese
• カニクイザルでのH5N1高病原性トリインフルエンザ組換えワクシニアワクチンの単回接種による長期防御効果の検討
  安井文彦; 宗片圭祐; 倉石武; 服部正策; 藤幸知子; 米田美佐子; 迫田義博; 喜田宏; 甲斐知恵子; 小原道法, 日本ワクチン学会学術集会プログラム・抄録集, 17th, 87, 2013
  Japanese
• 急性呼吸器感染症の感染メカニズムと疫学,感染予防・制御に関する研究 鳥,ブタなどのインフルエンザ疫学と感染制御体制の検討
  喜田宏, 急性呼吸器感染症の感染メカニズムと疫学、感染予防・制御に関する研究 平成24年度 総括・分担研究報告書, 77, 81, 2013
  Japanese
• 蛍光イムノクロマトグラフィ法を用いた高病原性トリインフルエンザウイルスH5亜型の広域検出法の確立
  櫻井陽; 高山勝好; 野村奈美子; 迫田義博; 須田美彦; 小林行治; 阪口薫雄; 喜田宏; 小原道法; 芝崎太, 日本分子生物学会年会プログラム・要旨集(Web), 36th, WEB ONLY 3P-1007, 2013
  Japanese
• 微生物と感染症診療 高病原性鳥インフルエンザとパンデミックインフルエンザ
  喜田 宏, 感染症道場, 2, 1, 30, 33, Jan. 2013
  メディカルレビュー社, Japanese
• Unmasking of the Nature of Avian Influenza for the Successful Control
  Hiroshi Kida, JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, 60, 7, 371, 374, 2013
  Japanese
• パンデミックインフルエンザの発生に即応した,ワクチン製造用種ウイルス株の作出―インフルエンザウイルスライブラリーの利用―
  岡本成史; 竹中延之; 迫田義博; 岡松正敏; 山本直樹; ハリディ アーマド; 山田博司; 森康子; 喜田宏; 山西弘一, 日本ウイルス学会学術集会プログラム・抄録集, 60th, 263, 31 Oct. 2012
  Japanese
• 鳥インフルエンザウイルスがブタに感染するとSAα2,6Galレセプターを認識するウイルスが選択される
  七戸新太郎; 岡松正敏; 迫田義博; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 60th, 167, 31 Oct. 2012
  Japanese
• 豚コレラウイルス非構造蛋白N^proのアミノ酸を置換したウイルスの感染に対する豚の自然免疫応答と病原性の解析
  田村友和; 長島尚史; 山本直樹; 岡松正敏; NICOLAS Ruggli; 迫田義博; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 60th, 250, 31 Oct. 2012
  Japanese
• H3N2インフルエンザウイルスHAへの糖鎖付加と周辺アミノ酸残基にかかる選択圧の経詩的変化
  五十嵐学; 中尾亮; 喜田宏; 高田礼人; 伊藤公人, 日本ウイルス学会学術集会プログラム・抄録集, 60th, 318, 31 Oct. 2012
  Japanese
• Migratory birds and influenza
  喜田 宏, 科学, 82, 8, 918, 922, Aug. 2012
  岩波書店, Japanese
• Effects of Disinfectant Containing Glutaraldehyde Against Avian Influenza Virus
  SAKODA Yoshihiro; ENDO Mayumi; SATO Yuka; OKAMATSU Masatoshi; KIDA Hiroshi, Journal of the Japan Veterinary Medical Association, 65, 4, 303, 305, 20 Apr. 2012
  The inactivation of avian influenza virus using disinfectant including glutaraldehyde was investigated. The disinfectant showed sufficient effect to inactivate avian influenza virus with contamination of fecal materials in the mixture. However, the effectiveness of the disinfectant was limited under conditions with low reaction temperature. In addition, the disinfectant requires a longer reaction time to inactivate avian influenza virus than that of cationic detergent. It was concluded that disinfectant containing glutaraldehyde was effective to inactivate avian influenza viruses under appropriate conditions., Japan Veterinary Medical Association, Japanese
• 豚インフルエンザ総説 (特集 インフルエンザから豚を守ろう)
  喜田 宏; 七戸 新太郎, 養豚の友, 0, 515, 14, 16, Feb. 2012
  日本畜産振興会, Japanese
• Galectin-9は細胞およびマウスにおけるインフルエンザAウイルスの感染を抑制する
  服部ともえ; 服部ともえ; 丸山隼輝; 藤岡容一朗; 中山洋佑; 大場雄介; 仁木敏郎; 有川智博; 宮崎忠昭; 平島光臣; 喜田宏; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 60th, 2012
• 豚コレラウイルスの豚における増殖とサイトカイン応答
  長島尚史; 迫田義博; 田村友和; 山本直樹; 岡松正敏; NICOLAS Ruggli; 喜田宏; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 60th, 2012
• 豚コレラウイルスの病原性に関与するアミノ酸置換が宿主のサイトカイン応答に及ぼす影響
  長島尚史; 迫田義博; 田村友和; 栗林沙弥; 山本直樹; 岡松正敏; RUGGLI Nicolas; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 153rd, 2012
• 北海道で分離された牛ウイルス性下痢ウイルス1aおよび1b亜型株の遺伝子と抗原性の解析
  安部優里; 迫田義博; 三津橋和也; 田村友和; 長島尚史; 岡松正敏; 長井誠; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 154th, 2012
• 対談 鳥インフルエンザの諸問題
  柏木 征三郎; 喜田 宏, インフルエンザ, 13, 1, 9, 19, Jan. 2012
  メディカルレビュー社, Japanese
• Introduction : Strategy for the Control of Zoonoses
  喜田 宏, 最新医学, 66, 12, 2609, 2611, Dec. 2011
  最新医学社, Japanese
• 対談 人獣共通感染症の克服対策 (特集 人獣共通感染症の克服に向けて)
  倉田 毅; 喜田 宏, 最新医学, 66, 12, 2612, 2622, Dec. 2011
  最新医学社, Japanese
• Influenza
  喜田 宏, 最新医学, 66, 12, 2623, 2631, Dec. 2011
  最新医学社, Japanese
• 高病原性鳥インフルエンザと対策(3・最終回)鳥とヒトのインフルエンザ対策はいかにあるべきか
  喜田 宏, 鶏の研究, 86, 12, 22, 25, Dec. 2011
  木香書房, Japanese
• 高病原性鳥インフルエンザと対策(2)H5N1高病原性インフルエンザウイルスが常在化したのはなぜか
  喜田 宏, 鶏の研究, 86, 11, 14, 17, Nov. 2011
  木香書房, Japanese
• 高病原性鳥インフルエンザと対策(1)高病原性インフルエンザ発生の現状
  喜田 宏, 鶏の研究, 86, 10, 14, 17, Oct. 2011
  木香書房, Japanese
• 2009年のウズラ由来H7N6亜型高病原性鳥インフルエンザウイルスの感染経路の推定
  内田 裕子; 金平 克史; 真瀬 昌司; 竹前 喜洋; 渡辺 千晶; 笛吹 達史; 藤本 佳万; 伊藤 壽啓; 五十嵐 学; 伊藤 公人; 高田 礼人; 迫田 義博; 岡松 正敏; 山本 祐; 中村 菊保; 喜田 宏; 廣本 靖明; 津田 知幸; 西藤 岳彦, 動物衛生研究成果情報, 10, 15, 16, Sep. 2011
  (国研)農業・食品産業技術総合研究機構動物衛生研究所, Japanese
• 高病原性鳥インフルエンザの畜産と公衆衛生に与えるインパクト--ワクチン頼みから摘発・淘汰に転換することがウイルスを一掃する (特集 冬場に向けた衛生対策--畜種別の留意点と感染症予防対策・畜舎環境改善)
  喜田 宏, 畜産コンサルタント, 47, 9, 24, 29, Sep. 2011
  中央畜産会, Japanese
• 人獣共通感染症リサーチセンター・喜田宏氏の講演より インフルエンザウイルスの生態を知る
  喜田 宏, 養鶏の友, 595, 34, 41, Sep. 2011
  日本畜産振興会, Japanese
• 2010‐2011年に日本で野鳥から分離されたH5N1高病原性鳥インフルエンザウイルス
  岡松正敏; 伊藤啓史; 内田裕子; 迫田義博; 山本直樹; 曽田公輔; 笛吹達史; 尾崎弘一; 山口剛士; 村瀬敏之; 伊藤壽啓; 西藤岳彦; 喜田宏, 日本獣医学会学術集会講演要旨集, 152nd, 231, 31 Aug. 2011
  Japanese
• 高病原性鳥インフルエンザの防疫--迅速診断、摘発・淘汰が基本
  喜田 宏, 鶏の研究, 86, 6, 52, 54, Jun. 2011
  木香書房, Japanese
• 鳥インフル克服に向け抜本対策を (特集 「家畜災害」克服への検証)
  喜田 宏, AFCフォーラム, 58, 13, 3, 6, Apr. 2011
  日本政策金融公庫農林水産事業本部, Japanese
• 高病原性鳥インフルエンザの防疫 (特集 高病原性鳥インフルエンザの対策と実態)
  喜田 宏, 畜産技術, 0, 671, 2, 6, Apr. 2011
  畜産技術協会, Japanese
• 豚コレラウイルス非構造蛋白N^proへのアミノ酸変異導入による自然免疫の抑制と豚に対する病原性の上昇
  迫田義博; 田村友和; 長島尚史; 山本直樹; 岡松正敏; RUGGLI Nicolas; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 152nd, 2011
• 豚コレラ弱毒生ワクチン株の豚継代による病原性獲得に与る因子の検索
  田村友和; 迫田義博; 吉野史; 長島尚史; 山本直樹; 佐藤由佳; 岡松正敏; RUGGLI Nicolas; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 152nd, 2011
• 牛ウイルス性下痢ウイルス2b亜型(BVDV‐2b)株の性状
  TAMURA TOMOKAZU; SAKODA YOSHIHIRO; YOSHINO FUMI; SUGITA MASAHIKO; OKAMATSU MASATOSHI; NAGAI MAKOTO; ITO MIKA; AOKI HIROSHI; KIDA HIROSHI, 日本ウイルス学会学術集会プログラム・抄録集, 58th, 275, 15 Oct. 2010
  Japanese
• H3N2インフルエンザウイルスHAに付加された糖鎖は周辺エピトープを覆い隠していたか?〜糖鎖付加部位周辺アミノ酸残基の多様性変化の解析〜
  五十嵐学; 高田礼人; 喜田宏; 喜田宏; 喜田宏; 伊藤公人; 伊藤公人, 日本ウイルス学会学術集会プログラム・抄録集, 58th, 227, 15 Oct. 2010
  Japanese
• パンデミックインフルエンザAウイルス(H1N1)ヘマグルチニンに対するモノクローナル抗体の性状解析
  吉田玲子; 苫米地大輔; 五十嵐学; 宮本洋子; 加瀬哲男; 喜田宏; 喜田宏; 喜田宏; 高田礼人, 日本ウイルス学会学術集会プログラム・抄録集, 58th, 219, 15 Oct. 2010
  Japanese
• 牛ウイルス性下痢ウイルス2b亜型(BVDV‐2b)株の性状
  TAMURA TOMOKAZU; SAKODA YOSHIHIRO; YOSHINO FUMI; OKAMATSU MASATOSHI; NAGAI MAKOTO; ITO MIKA; AOKI HIROSHI; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 150th, 234, 234, 01 Sep. 2010
  (公社)日本獣医学会, Japanese
• パンデミックの出現に関する展望と今後の対策 (特集 検証「パンデミックインフルエンザ2009」)
  喜田 宏, 公衆衛生, 74, 8, 687, 690, Aug. 2010
  医学書院, Japanese
• Looking back upon the confusion of avian, swine, and pandemic influenza
  KIDA Hiroshi, Virus, 60, 1, 17, 20, 01 Jun. 2010
  日本ウィルス学会, Japanese
• Intravenous peramivir for treatment of influenza A and B infection in high-risk patients
  S. Kohno; H. Kida; M. Mizuguchi; N. Hirotsu; T. Ishida; J. Kadota; J. Shimada, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 14, E85, E86, Mar. 2010
  English, Summary international conference
• Epidemiology of avian influenza viruses in wild birds in Mongolia
  E. -O. Tseren-Ochir; B. Damdinjav; T. Sharkhuu; H. M. Kang; Y. Sakoda; B. Purevsuren; S. Ruuragchaa; Y. J. Lee; H. Kida; B. Khishgee; S. Sengee, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 14, E164, E165, Mar. 2010
  English, Summary international conference
• 近年北海道で分離された牛ウイルス性下痢ウイルスの遺伝子解析
  田村友和; 迫田義博; 杉田征彦; 吉野史; 岡松正敏; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 149th, 2010
• 近年北海道で分離された牛ウイルス性下痢ウイルスの遺伝子と抗原性の解析
  迫田義博; 田村友和; 杉田征彦; 吉野史; 岡松正敏; 喜田宏; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 58th, 2010
• H9N2インフルエンザウイルスはニワトリに対する病原性を獲得するか?
  曽田公輔; 浅倉真吾; 岡松正敏; 迫田義博; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 149th, 2010
• A Novel Type of Hereditary Motor and Sensory Neuropathy with Proximal Dominancy in the Lower Extremities Found in a Japanese Descent
  Shiroh Miura; Hiroki Shibata; Kazuhito Noda; Yoichiro Kaku; Hiroshi Kida; Akiko Iwaki; Mitsuyoshi Ayabe; Hisamichi Aizawa; Takayuki Taniwaki, ANNALS OF NEUROLOGY, 68, 4, S52, S52, 2010
  English, Summary international conference
• Avian, swine, and pandemic influenza: preparedness for pandemic influenza should be based on the measures how to control seasonal influenza
  喜田 宏, 最新医学, 65, 1, 13, 20, Jan. 2010
  最新医学社, Japanese
• Virucidal efficacy of povidone-iodine products against swine influenza viruses
  ITO Hiroshi; HIKIDA Muneo; YASHIRO Junko; KIDA Hiroshi; ITO Toshihiro, 日本化学療法学会雜誌 = Japanese journal of chemotherapy, 57, 6, 508, 510, 10 Nov. 2009
  Japanese
• MOUSE MODEL OF INFLUENZA VIRUS-ASSOCIATED ENCEPHALOPATHY OF CHILDHOOD
  T. Tanaka; Y. Sunden; G. Tanoue; K. Ochiai; Y. Sakoda; H. Kida; T. Umemura, JOURNAL OF COMPARATIVE PATHOLOGY, 141, 4, 277, 277, Nov. 2009
  English, Summary international conference
• ホモロジーモデリング法による新型H1N1インフルエンザウイルスのヘマグルチニンの抗原構造の解析
  五十嵐学; 伊藤公人; 吉田玲子; 喜田宏; 喜田宏; 喜田宏; 高田礼人, 日本ウイルス学会学術集会プログラム・抄録集, 57th, 180, 01 Oct. 2009
  Japanese
• インフルエンザウイルスのヘマグルチニンのMDS解析と変異予測への応用
  伊藤公人; 五十嵐学; 村上悌治; 喜田宏; 喜田宏; 高田礼人, 日本ウイルス学会学術集会プログラム・抄録集, 57th, 181, 01 Oct. 2009
  Japanese
• 鳥,ブタ,そしてパンデミックインフルエンザ--実はすべてインフルエンザ (特集 現場の経験を活かすパンデミック対策)
  喜田 宏, 月刊薬事, 51, 11, 1597, 1603, Oct. 2009
  じほう, Japanese
• 1SA2-07 Avian, swine, and pandemic influenza(1SA2 BSJ&ABA Joint Symposium, "Prion and Virus Infections",The 47th Annual Meeting of the Biophysical Society of Japan)
  Kida Hiroshi, Biophysics, 49, 1, S4, 20 Sep. 2009
  The Biophysical Society of Japan, English
• 本来あるべきインフルエンザ対策とは? (新型インフルエンザの実態)
  喜田 宏, メディカルバイオ, 6, 4, 75, 77, Jul. 2009
  オーム社, Japanese
• 鼎談 パンデミック前にH5N1ウイルスワクチンを接種すべきなのか,すべきではないのか
  河岡 義裕; 西村 秀一; 喜田 宏, インフルエンザ, 10, 3, 191, 202, Jul. 2009
  メディカルレビュー社, Japanese
• H5亜型ウイルスに対する鳥インフルエンザワクチンの開発 : 高力価のワクチンを開発. H7ウイルス用もスタンバイ
  磯田 典和; 迫田 義博; 喜田 宏, 化学と生物, 47, 5, 302, 304, 01 May 2009
  社団法人 日本農芸化学会, Japanese
• JAPHV [平成]20年度研修 特別講演 鳥インフルエンザと新型ウイルス[含 質疑応答]
  喜田 宏, 獣医公衆衛生研究, 11, 2, 27, 39, Mar. 2009
  全国公衆衛生獣医師協議会, Japanese
• 最優秀賞 インフルエンザウイルスの生態解明とライブラリーの構築--高病原性鳥インフルエンザの診断と予防への応用 (畜産大賞 『研究開発部門』最優秀賞・優秀賞の紹介)
  喜田 宏, 畜産技術, 0, 646, 43, 48, Mar. 2009
  畜産技術協会, Japanese
• 国内開発鳥インフルエンザワクチン
  佐々木 崇; 坂元 隆一; 今村 孝; 坂口 正士; 瀧川 義康; 西條 加須江; 澤田 章; 萩原 純子; 土屋 耕太郎; 林 志鋒; 國米 則秀; 扇谷 年昭; 曽田 公輔; 磯田 典和; 迫田 義博; 喜田 宏, 鶏病研究会報, 44, 4, 170, 174, 25 Feb. 2009
  鶏病研究会, Japanese
• H9N2インフルエンザウイルスはニワトリに対する病原性を獲得するか?
  曽田公輔; 浅倉真吾; 岡松正敏; 迫田義博; 喜田宏; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 57th, 2009
• 近年流行を起こしているH3N8馬インフルエンザウイルスの遺伝子と抗原性の解析
  本島昌幸; 岡松正敏; 浅倉真吾; 伊藤美加; 前田友起子; 福田奈穂; SODNOMDARJAA R.; 迫田義博; 喜田宏; 喜田宏, 日本ウイルス学会北海道支部夏季シンポジウム講演抄録, 43rd, 2009
• カニクイザルを用いた高病原性鳥インフルエンザウイルスに対するワクチンの防御効果の判定
  伊藤靖; 尾崎弘一; 曽田公輔; 迫田義博; 石垣宏仁; 仲山美沙子; 石田英晃; 永田智也; 三宅太一郎; 喜田宏; 喜田宏; 小笠原一誠, 日本ワクチン学会学術集会プログラム・抄録集, 13th, 2009
• 今年のインフルエンザをどう乗り切るか (特集 呼吸器領域における漢方薬のエビデンス) -- (新型・季節性インフルエンザ)
  岡部 信彦; 河合 直樹; 喜田 宏, 漢方医学, 33, 4, 468, 470, 2009
  臨床情報センター, Japanese
• 講演要旨 インフルエンザはどこから来たのか?[含 質疑応答]
  喜田 宏, 読売クオータリー, 0, 10, 72, 81, 2009
  読売新聞東京本社調査研究本部, Japanese
• 座談会 パンデミックインフルエンザ--鳥,ブタ,そしてヒトのインフルエンザ対策の要点
  喜田 宏; 西藤 岳彦; 岩崎 惠美子, Virus report, 6, 2, 12, 24, 2009
  医薬ジャーナル社, Japanese
• インフルエンザウイルスの起源,進化と宿主域--新型ウイルスの出現に備えて (特集・新型インフルエンザの流行とその対策)
  喜田 宏, 医薬ジャ-ナル, 44, 11, 85, 92, Nov. 2008
  医薬ジャ-ナル社, Japanese
• H5N1不活化インフルエンザワクチンのクレード間交差防御免疫能の解析
  村上晋; 岩佐彩香; 岩附(堀本)研子; 伊藤睦美; 木曽真紀; 喜田宏; 高田礼人; NIDOM Chairul A; LE QUYNH Mai; 山田晋弥; 今井博貴; 坂井(田川)優子; 河岡義裕; 堀本泰介, 日本ウイルス学会学術集会プログラム・抄録集, 56th, 224, 01 Oct. 2008
  Japanese
• 2008年北海道で発見された斃死オオハクチョウから分離したH5N1高病原性鳥インフルエンザウイルスの性状
  岡松正敏; 迫田義博; 吉田裕美; 田中智久; 津田祥美; 磯田典和; 中山絵里; 苫米地大輔; 松野啓太; 梅村孝司; 高田礼人; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 56th, 263, 01 Oct. 2008
  Japanese
• H5N1インフルエンザウイルスのPB2に会合する宿主細胞因子の同定とその機能解析
  塩崎拓也; 岩井淳; 河岡義裕; 高田礼人; 喜田宏; 宮崎忠昭, 日本ウイルス学会学術集会プログラム・抄録集, 56th, 379, 01 Oct. 2008
  Japanese
• インフルエンザウイルスHA遺伝子の塩基配列上に潜在する糖鎖付加ポテンシャルの解析
  五十嵐学; 伊藤公人; 喜田宏; 喜田宏; 喜田宏; 高田礼人, 日本ウイルス学会学術集会プログラム・抄録集, 56th, 144, 01 Oct. 2008
  Japanese
• 2008年北海道で発見された斃死オオハクチョウから分離したH5N1高病原性鳥インフルエンザウイルスの性状
  岡松正敏; 迫田義博; 吉田裕美; 田中智久; 津田祥美; 磯田典和; 中山絵里; 苫米地大輔; 松野啓太; 梅村孝司; 高田礼人; 喜田宏, 日本獣医学会学術集会講演要旨集, 146th, 193, 05 Sep. 2008
  Japanese
• Genetic Analyses of an H3N8 Influenza Virus Isolate, Causative Strain of the Outbreak of Equine Influenza at the Kanazawa Racecourse in Japan in 2007
  Mika Ito; Makoto Nagai; Yuji Hayakawa; Hirofumi Komae; Naruto Murakami; Syouichi Yotsuya; Shingo Asakura; Yoshihiro Sakoda; Hiroshi Kida, JOURNAL OF VETERINARY MEDICAL SCIENCE, 70, 9, 899, 906, Sep. 2008
  English
• Development of a pen-site test kit for the rapid diagnosis of H7 highly pathogenic avian influenza
  Rashid Manzoor; Yoshihiro Sakoda; Saori Sakabe; Tsuyoshi Mochizuki; Yasuharu Namba; Yoshimi Tsuda; Hiroshi Kida, JOURNAL OF VETERINARY MEDICAL SCIENCE, 70, 6, 557, 562, Jun. 2008
  English
• インフルエンザウイルスの生態
  喜田 宏, 臨床とウイルス, 36, 2, S19, S20, 16 May 2008
  Japanese
• Evaluation of Vaccination Program by Commercial Polyvalent Vaccines for Bovine Viral Diarrhea and Infectious Bovine Rhinotracheitis Based on Neutralizing Antibody Response
  ITO Asako; SAKODA Yoshihiro; KAMEYAMA Ken-ichiro; YAMAZAKI Yukio; USUI Akira; KIDA Hiroshi, Journal of the Japan Veterinary Medical Association, 61, 1, 39, 42, 20 Jan. 2008
  To establish an effective vaccination program for bovine viral diarrhea (BVD) and infectious bovine rhinotracheitis, cattle were inoculated with commercial polyvalent vaccines which contain inactivated BVD virus, which were seronegative for BVD virus and bovine herpes virus 1. A single shot of the vaccines induced little antibody response in these cattle. One month after the second vaccination, a significant presence of neutralizing antibodies was detected in cattle and antibody titers decreased gradually. It was also demonstrated that an additional shot of the vaccines at 12 months after the first vaccination induced antibody response enough to prevent manifestation of disease signs. On the basis of the present results, two vaccinations and an annual, Japan Veterinary Medical Association, Japanese
• 日本とモンゴルで馬から分離されたH3N8インフルエンザウイルスの遺伝子と抗原性の解析
  浅倉真吾; 浅倉真吾; 迫田義博; 迫田義博; 長井誠; 若本裕昌; 喜田宏; 喜田宏; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 56th, 2008
• 日本とモンゴルで馬から分離されたH3N8インフルエンザウイルスの遺伝子および抗原性の解析
  浅倉真吾; 迫田義博; 伊藤美加; 長井誠; 前田友起子; 福田奈穂; 阿部修二; BATCHULUUN D.; SODNOMDARJAA R.; 若本裕晶; 岡松正敏; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 146th, 2008
• H9N2インフルエンザウイルスはニワトリに対する病原性を獲得するか?
  曽田公輔; 曽田公輔; 浅倉真吾; 浅倉真吾; 岡松正敏; 岡松正敏; 迫田義博; 迫田義博; 喜田宏; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 146th, 2008
• 鳥インフルエンザウイルスの病原性獲得メカニズムの解析
  曽田公輔; 曽田公輔; 浅倉真吾; 浅倉真吾; 岡松正敏; 岡松正敏; 迫田義博; 迫田義博; 喜田宏; 喜田宏; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 56th, 2008
• インフルエンザウイルスHA遺伝子の塩基配列上に潜在する糖鎖付加ポテンシャルの解析
  五十嵐学; 伊藤公人; 喜田宏; 喜田宏; 喜田宏; 高田礼人, 日本ウイルス学会北海道支部夏季シンポジウム講演抄録, 42nd, 12, 2008
  Japanese
• アジア・アフリカ地域の鳥インフルエンザ 世界的まん延に危機感--「アジア・アフリカ地域における鳥インフルエンザの現状と国際的な取組みについてのシンポジウム」より
  喜田 宏; 山田 幸雄; 藤田 陽偉, 鶏の研究, 83, 1, 108, 111, Jan. 2008
  木香書房, Japanese
• 動物インフルエンザのグローバルサーベイランスと全ての亜型ウイルスライブラリーの構築
  梶原将大; 梶原将大; 迫田義博; 迫田義博; 伊藤壽啓; 高田礼人; 岸田典子; 五十嵐学; 磯田典和; 磯田典和; 曽田公輔; 曽田公輔; 喜田宏; 喜田宏; 喜田宏, 日本ウイルス学会学術集会プログラム・抄録集, 55th, 216, 01 Oct. 2007
  Japanese
• インフルエンザの過去, 現在, 未来
  喜田 宏, 臨床と微生物 = Clinical microbiology, 34, 5, 395, 401, 25 Sep. 2007
  Japanese
• 鳥インフルエンザに対するワクチンの開発
  磯田 典和; 喜田 宏, ファームステージ, 7, 6, 84, 87, Sep. 2007
  技術情報協会, Japanese
• 動物インフルエンザのグローバルサーベイランスと全ての亜型ウイルスライブラリーの構築
  梶原将大; 梶原将大; 迫田義博; 迫田義博; 伊藤壽啓; 高田礼人; 伊藤公人; 岸田典子; 五十嵐学; 磯田典和; 磯田典和; 曽田公輔; 曽田公輔; WEBSTER R.G; 喜田宏; 喜田宏; 喜田宏, 日本獣医学会学術集会講演要旨集, 144th, 91, 27 Aug. 2007
  Japanese
• Effects of Disinfectants Against Avian Influenza Viruses
  SAKODA Yoshihiro; YOSHIMI Yasushi; KUROKAWA Satoru; KIDA Hiroshi, Journal of the Japan Veterinary Medical Association, 60, 7, 519, 522, 20 Jul. 2007
  市販消毒薬5品の鳥インフルエンザウイルス不活化効果を調べた。消毒薬はいずれもウイルスの亜型と病原性に関わらず、高希釈でウイルスの感染性を消失させた。希釈した薬液の凍結融解の繰り返しは消毒効果に影響を与えなかったが、低温下および有機物として鶏糞を添加した場合、消毒効果の減少が認められた。以上の結果から、試験に用いた消毒薬は反応温度や有機物の混入などの環境要因を十分に理解した上で適切に使用すれば鳥インフルエンザウイルスの不活化に有効であることがわかった。, 日本獸医師会, Japanese
• 鳥インフルエンザのワクチン開発
  迫田 義博; 喜田 宏, 鶏病研究会報, 43, 1, 32, 33, 25 May 2007
  Japanese
• Genetic and pathobiological characterization of bovine viral diarrhea viruses recently isolated from cattle in Japan
  Keita Matsuno; Yoshihiro Sakoda; Ken-ichiro Kameyama; Kyuzo Tamai; Asako Ito; Hiroshi Kida, JOURNAL OF VETERINARY MEDICAL SCIENCE, 69, 5, 515, 520, May 2007
  English
• 人獣共通感染症の克服を目指して (特集 鳥インフルエンザを経験した京都からの発信)
  喜田 宏, 養鶏の友, 541, 36, 38, Mar. 2007
  日本畜産振興会, Japanese
• Effects of disinfectants against avian influenza virus
  迫田 義博; 関 令二; 喜田 宏, The Japanese journal of animal hygiene, 32, 2, 67, 70, Mar. 2007
  日本家畜衛生学会, Japanese
• Serological evidence of influenza A virus infection in Kuril harbor seals (Phoca vitulina stejnegeri) of Hokkaido, Japan
  Kei Fujii; Chiharu Kakumoto; Mari Kobayashi; Sachiko Saito; Tatsuya Kariya; Yukiko Watanabe; Yoshihiro Sakoda; Hiroshi Kida; Masatsugu Suzuki, JOURNAL OF VETERINARY MEDICAL SCIENCE, 69, 3, 259, 263, Mar. 2007
  English
• インフルエンザウイルス亜型間交差中和活性を有するモノクローナル抗体の解析
  吉田玲子; 五十嵐学; 喜田宏; 喜田宏; 喜田宏; 高田礼人, 日本ウイルス学会学術集会プログラム・抄録集, 54th, 347, 01 Nov. 2006
  Japanese
• グローバルサーベイランスの重要性 (特集 インフルエンザをめぐる諸問題)
  尾崎 弘一; 喜田 宏, アレルギ-・免疫, 13, 11, 1530, 1535, Nov. 2006
  医薬ジャ-ナル社, Japanese
• Efficacy of intracerebral vaccination against pseudorabies virus in mice
  Jae-Ho Shin; Yoshihiro Sakoda; Jae Hoon Kim; Tomohisa Tanaka; Hiroshi Kida; Takashi Kimura; Kenji Ochiai; Takashi Umemura, JOURNAL OF NEUROIMMUNOLOGY, 178, 114, 114, Sep. 2006
  English, Summary international conference
• Pathogenicity of H5N1 influenza A viruses isolated in Vietnam between late 2003 and 2005
  Yukiko Muramoto; Thi Quynh Mai Le; Lien Song Phuong; Tung Nguyen; Thu Ha Nguyen; Yuko Sakai-Tagawa; Taisuke Horimoto; Hiroshi Kida; Yoshihiro Kawaoka, JOURNAL OF VETERINARY MEDICAL SCIENCE, 68, 7, 735, 737, Jul. 2006
  English
• Molecular characterization of the hemagglutinin and neuraminidase genes of H5N1 influenza A viruses isolated from poultry in Vietnam from 2004 to 2005
  Y Muramoto; TQM Le; LS Phuong; T Nguyen; TH Nguyen; Y Sakai-Tagawa; K Iwatsuki-Horimoto; T Horimoto; H Kida; Y Kawaoka, JOURNAL OF VETERINARY MEDICAL SCIENCE, 68, 5, 527, 531, May 2006
  English
• 鳥インフルエンザウイルスについて (特集 高病原性鳥インフルエンザについて)
  喜田 宏, 畜産技術, 0, 611, 6, 11, Apr. 2006
  畜産技術協会, Japanese
• 人獣共通感染症としての高病原性鳥インフルエンザとワクチン (特集 インフルエンザウイルス感染症と関連するワクチンの臨床) -- (インフルエンザウイルス感染症の特殊な病態と合併症)
  喜田 宏, 日本医師会雑誌, 134, 10, 1940, 1944, Jan. 2006
  日本医師会, Japanese
• Improvement of a rapid diagnosis kit to detect either influenza a or B virus infections
  GR Bai; Y Sakoda; AS Mweene; N Fujii; H Minakawa; H Kida, JOURNAL OF VETERINARY MEDICAL SCIENCE, 68, 1, 35, 40, Jan. 2006
  English
• Ecology of influenza virus
  KIDA Y, 日本豚病研究会報 = Proceedings of the Japanese Pig Veterinary Society, 47, 16, 17, 01 Aug. 2005
  日本豚病研究会, Japanese
• 鼎談 ウイルスとその宿主をとりまく環境
  河岡 義裕; 倉根 一郎; 喜田 宏, Virus report, 2, 1, 8, 13, Jun. 2005
  医薬ジャーナル社, Japanese
• Ecology of avian influenza viruses
  Kida H, Medical entomology and zoology, 56, 0, 30, 30, 01 Jun. 2005
  The Japan Society of Medical Entomology and Zoology, Japanese
• 座談会 Avian influenza (鳥インフルエンザ特集号)
  Webster R. G; 永井 美之; 喜田 宏, インフルエンザ, 6, 2, 113, 124, Apr. 2005
  メディカルレビュー社, Japanese
• Nucleocapsid-like structures of Ebola virus reconstructed using electron tomography
  T Noda; K Aoyama; H Sagara; H Kida; Y Kawaoka, JOURNAL OF VETERINARY MEDICAL SCIENCE, 67, 3, 325, 328, Mar. 2005
  English
• Virucidal efficacy of povidone-iodine products against avian influenza viruses
  ITO Hiroshi; HIKIDA Muneo; OTSUKA Akira; YASHIRO Junko; KIDA Hiroshi; OTSUKI Koichi; ITO Toshihiro, Japanese Journal of Chemotherapy, 53, 1, 20, 22, 25 Jan. 2005
  Japanese
• 特集 2005年新年号座談会:新興・再興感染症の現状と防疫をめぐって
  喜田 宏; 栗本 まさ子; 高崎 智彦, 畜産技術, 0, 596, 2, 19, Jan. 2005
  畜産技術協会, Japanese
• 基礎から臨床へ 動物からヒトへ--人獣共通感染症を克服するために
  喜田 宏, 診断と治療, 92, 12, 2289, 2295, Dec. 2004
  診断と治療社, Japanese
• 新型インフルエンザと鳥インフルエンザ (特集:エマージング感染症の時代)
  喜田 宏, 現代化学, 0, 404, 27, 31, Nov. 2004
  東京化学同人, Japanese
• パネルディスカッション 平成16年度北日本養鶏研究大会より(3)高病原性鳥インフルエンザ--ワクチン接種の効果と論点について
  所 源亮; 喜田 宏; 境 政人, 鶏卵肉情報, 34, 20, 34, 37, 25 Oct. 2004
  鶏卵肉情報センタ-, Japanese
• パネルディスカッション 平成16年度北日本養鶏研究大会より(2)高病原性鳥インフルエンザ--ワクチン接種の効果と論点について
  所 源亮; 喜田 宏; 境 政人, 鶏卵肉情報, 34, 19, 18, 23, 10 Oct. 2004
  鶏卵肉情報センタ-, Japanese
• 鳥インフルエンザとは何か (特集 人と動物の共通感染症(1)鳥インフルエンザ)
  喜田 宏, 公衆衛生, 68, 10, 760, 763, Oct. 2004
  医学書院, Japanese
• パネルディスカッション 平成16年度北日本養鶏研究大会より(1)高病原性鳥インフルエンザ--ワクチン接種の効果と論点について
  所 源亮; 喜田 宏; 境 政人, 鶏卵肉情報, 34, 18, 38, 44, 25 Sep. 2004
  鶏卵肉情報センタ-, Japanese
• 鳥インフルエンザと新型インフルエンザ
  喜田 宏, 日本臨床免疫学会会誌 = Japanese journal of clinical immunology, 27, 4, 242, 242, 31 Aug. 2004
  日本臨床免疫学会, Japanese
• 人獣共通感染症の克服に向けて
  喜田 宏, 日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association, 57, 8, 471, 476, 20 Aug. 2004
  日本獣医師会, Japanese
• 座談会「高病原性鳥インフルエンザをめぐって」
  永井 美之; 大槻 公一; 岡部 信彦; 河岡 義裕; 喜田 宏; 倉田 毅; 佐多 徹太郎; 田代 眞人; 山口 成夫; 吉倉 廣, ウイルス, 54, 1, 123, 141, 30 Jun. 2004
  日本ウィルス学会, Japanese
• Avian influenza virus
  KIDA Hiroshi, Virus, 54, 1, 93, 96, 30 Jun. 2004
  Recent outbreaks of highly pathogenic avian influenza in chickens and ducks that occurred in 9 Asian countries including Japan alarmed to realize that there is no border for infections and gave a rise to great concern for human health as well as for agriculture. This H5N1 virus jumped the species barrier and caused severe disease with high mortality in humans in Viet Nam and Thailand ; 15 deaths of 22 cases and 8 of 12, respectively.A second concern was the possibility that the situation could give rise to another influenza pandemic in humans since genetic reassortment may occur between avian and human influenza viruses when a person is concurrently infected with viruses from both species. This process of gene swapping inside the human body can give rise to a new subtype of the influenza virus to which humans would not have immunity. The outbreaks also emphasized the need to continue active surveillance on avian influenza throughout the year to undertake aggressive emergency control measures as soon as an infection is detected., The Japanese Society for Virology, Japanese
• 鳥インフルエンザウイルスと新型インフルエンザウイルス
  喜田 宏, 臨床とウイルス, 32, 2, S18, 31 May 2004
  Japanese
• 鳥インフルエンザワクチン接種是非論争 ワクチン接種すべきでない
  喜田 宏, 週刊農林, 0, 1881, 8, 8, 15 Mar. 2004
  農林出版社, Japanese
• Subcutaneous hematoma due to frequent insulin injections in a single site
  Toshio Kahara; Shigeru Kawara; Akiko Shimizu; Azusa Hisada; Yutaka Noto; Hiroshi Kida, Internal Medicine, 43, 2, 148, 149, Feb. 2004
  English, Report scientific journal
• Development of malignancy after treatment of idiopathic membranous nephropathy [7] (multiple letters)
  Ming-Y.U. Lai; W.U.-Chang Yang; Chih-Ching Lin; Keiichi Yoshimoto; Hitoshi Yokoyama; Takashi Wada; Kengo Furuichi; Satoshi Goshima; Hiroshi Kida, Kidney International, 66, 1, 464, 465, 2004
  Blackwell Publishing Inc., English, Report scientific journal
• Avian influenza viruses as the origin of pandemic strains
  Hiroshi Kida, JOURNAL OF NEUROVIROLOGY, 14, 14, 14, 2004
  English, Summary international conference
• Crisis management and international cooperation to influenza pandemic. Surveillance of influenza strains and development of new vaccine.
  小田切孝人; 西藤岳彦; 板村繁之; 小淵正次; 今井正樹; 二宮愛; 山下和予; 谷口清洲; 喜田宏, インフルエンザパンデミックに対する危機管理体制と国際対応に関する研究 平成15年度 総括・分担研究報告書, 34, 37, 2004
  Japanese
• Host range of influenza viruses and the development of new anti influenza agents
  Y Suzuki; IPJ Hidari; D Miyamoto; T Suzuki; CT Guo; T Ito; H Kida; Y Kawaoka, JOURNAL OF CLINICAL VIROLOGY, 28, S104, S105, Dec. 2003
  English, Summary international conference
• 鳥インフルエンザウイルスの感染性に及ぼす消毒薬の効果について
  伊藤 壽啓; 喜田 宏; 大槻 公一, 家畜衛生学雑誌, 29, 2, 123, 126, Dec. 2003
  日本家畜衛生学会, Japanese
• 新型インフルエンザウイルス襲来 (世界を脅かす感染症とどう闘うか) -- (第1章 広がる脅威)
  野田 岳志; 喜田 宏; 河岡 義裕, 別冊日経サイエンス, 143, 10, 13, Nov. 2003
  日経サイエンス, Japanese
• The effects of antipyretics on influenza virus encephalitis in mice and chicks
  Y Sunden; CH Park; K Matsuda; A Anagawa; T Kimura; K Ochiai; H Kida; T Umemura, JOURNAL OF VETERINARY MEDICAL SCIENCE, 65, 11, 1185, 1188, Nov. 2003
  English
• Report of the 50th Annual Meeting of the Japanese Society for Virology
  KIDA Hiroshi, ウイルス, 53, 1, 93, 94, 01 Jun. 2003
  Japanese
• For the Prevention and Control of Pandemic Influenza
  KIDA Hiroshi, Virus, 53, 1, 71, 74, 01 Jun. 2003
  日本ウィルス学会, Japanese
• 牛ウイルス性下痢ウイルス非構造蛋白NS3に対するモノクローン抗体によるペスチウイルス属共通エピトープの検出
  TAMAI KYUZO; SAKODA YOSHIHIRO; AOKI HIROSHI; NAKAMURA SHIGEYUKI; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 135th, 131, 131, 25 Mar. 2003
  (公社)日本獣医学会, Japanese
• ヘルペスウイルスgBのα‐helix領域ペプチドによるウイルスの増殖阻害
  岡崎克則; 喜田宏, 日本獣医学会学術集会講演要旨集, 135th, 121, 25 Mar. 2003
  Japanese
• The immediate early gene of canine herpesvirus is transcribed through early and late phases
  M Miyoshi; K Okazaki; M Takiguchi; H Kida; A Hashimoto, JOURNAL OF VETERINARY MEDICAL SCIENCE, 64, 7, 627, 631, Jul. 2002
  English
• Zoonotic Influenza Virus : Emerging Mechanism of New Type Virus and Countermeasure to Influenza Virus
  KIDA Hiroshi, The Journal of veterinary epidemiology, 6, 1, 29, 33, 20 Jun. 2002
  1968年に出現した新型インフルエンザウイルスA/ホンコン/68 (H3N2) 株はカモがシベリアの営巣湖沼から家禽に持ち込んだウイルスとそれまでヒトに流行していたH2N2ウイルスが中国南部でブタの呼吸器に共感染して生じた遺伝子再集合体である。1957年の新型H2N2ウイルスも同様の経路で出現したものと推定される。1918年にスペインインフルエンザを引き起こしたH1N1ウイルスは北米大陸の系統の鳥類インフルエンザウイルスを起源とする。
  1997年に香港で18人に感染して6人を死亡させたH5N1ウイルスもまた, シベリアからカモが家禽に持ち込んだウイルスがニワトリに受け継がれる問に病原性を獲得したものである。1983年に米国ペンシルバニア州でH5N2ウイルスによる家禽ペストが発生して以来, 世界各地で家禽にインフルエンザが発生していることが判ってきた。水禽の弱毒ウイルスがニワトリに感染して伝播すると, ニワトリに対して病原性を獲得することがあり, これが家禽ペストを引き起こす。香港H5N1ウイルス事件はまた, 生鳥の小売りマーケットがインフルエンザウイルスの遺伝子プールであることを明らかにした。
  水禽, その営巣湖沼水, 家禽と家畜の疫学調査を強化し, 新型ウイルスの出現とその亜型を予測すると共に, 調査で分離されるウイルスの中から的確なワクチン株および診断抗原を選出して, 供給する計画がWHO, 日米医学協力研究会, 厚生労働省ならびに文部科学省に採択され, 動物インフルエンザのグローバルサーベイランスを推進している。, The Japan Society of Veterinary Epidemiology, Japanese
• Electron-dense deposition patterns and the outcomes of idiopathic membranous nephropathy in Japanese
  H. Yokoyama; Keiichi Yoshimoto; Takashi Wada; Kengo Furuichi; Satoshi Goshima; Hiroshi Kida; Ken-Ichi Kobayashi, Medical Electron Microscopy, 35, 2, 81, 86, Jun. 2002
  English, Book review
• インフルエンザウイルスのリバースジェネティクス--ウイルス改造現場からのレポート (特集 感染症発症の分子機構 宿主と病原体の分子の攻防)
  八田 正人; 渡辺 登喜子; 喜田 宏, モレキュラ-メディシン, 39, 2, 188, 195, Feb. 2002
  中山書店, Japanese
• 基礎 自然界におけるゲノムプールと新型インフルエンザウイルス (特集 微生物ゲノム情報と医学--基礎と臨床)
  喜田 宏, 現代医療, 34, 5, 1041, 1046, 2002
  現代医療社, Japanese
• 鼎談 新型インフルエンザウイルスの出現とインフルエンザ脳炎・脳症
  喜田 宏; 富樫 武弘; 河岡 義裕, インフルエンザ, 2, 3, 191, 206, Jul. 2001
  メディカルレビュー社, Japanese
• 基礎 新型インフルエンザウイルスの出現に備える
  喜田 宏, インフルエンザ, 2, 2, 127, 135, Apr. 2001
  メディカルレビュー社, Japanese
• 「新型」ウイルス出現のメカニズムとその流行予防対策 (特集 インフルエンザ) -- (21世紀のインフルエンザ)
  喜田 宏, 小児科診療, 63, 12, 2138, 2142, Dec. 2000
  診断と治療社, Japanese
• Genetic manipulation of influenza A viruses
  WATANABE Tokiko; KIDA Hiroshi; KAWAOKA Yoshihiro, Uirusu, 50, 1, 1, 9, 01 Jun. 2000
  A型インフルエンザウイルスは, 8本のマイナス鎖のRNA分節を遺伝子として持つウイルスである。最近, 我々は細胞内に存在するRNAポリメラーゼを利用することにより, 効率よくインフルエンザウイルス様粒子 (virus-like particles: VLP) を作出する系を確立し, さらに, その遺伝子が全てcDNAに由来するインフルエンザウイルスを生成する遺伝子操作技術を開発した。この技術を用いて, 細胞に1度だけ感染しウイルス蛋白質は発現するが, 新たな感染性粒子は産生しない"半生"インフルエンザワクチンを設計した。その効果をマウスを用いて検定したところ,"半生"ワクチンは顕著な感染防御効果を示した。このように, 新しい遺伝子操作技術はインフルエンザウイルスを自由に設計することを可能とし, 基礎研究のみならずワクチンやベクター開発に広く貢献することが期待される。, The Japanese Society for Virology, Japanese
• イヌヘルペスウイルス(CHV)感染新生子犬の脳病変におけるウイルス抗原及びウイルスゲノムの分布
  西野亜紀; 滝口満喜; 橋本晃; 岡崎克則; 喜田宏, 日本獣医学会学術集会講演要旨集, 129th, 47, 01 Mar. 2000
  Japanese
• ウシヘルペスウイルス1のリセプター特異性
  岡崎克則; 高田礼人; 喜田宏, 日本獣医学会学術集会講演要旨集, 129th, 86, 01 Mar. 2000
  Japanese
• ウマヘルペスウイルス1型脳脊髄炎のマウスを用いた実験的再現
  佐藤栄一; 梅村孝司; 落合謙爾; 向谷竜介; 岡崎克則; 喜田宏; 和田隆一, 日本獣医学会学術集会講演要旨集, 129th, 41, 01 Mar. 2000
  Japanese
• インフルエンザウイルスの分子生物学2 宿主域とレセプター特異性
  喜田宏, 治療学, 34, 33, 37, 2000
• インフルエンザは人獣共通伝染病-新型ウイルス出現のメカニズムと流行予防
  喜田宏, 綜合臨床, 49, 252, 255, 2000
• 新型インフルエンザウイルス出現のしくみと対策 (免疫と感染・癌)
  喜田 宏, 免疫, 2000, 0, 228, 235, 2000
  中山書店, Japanese
• 新型インフルエンザウイルスはどこからくるのか:出現のメカニズムと流行の予防 (特集 インフルエンザ 最強のウイルスの謎に迫る)
  喜田 宏, 細胞工学, 19, 1, 27, 32, Jan. 2000
  秀潤社, Japanese
• 動物とヒトのインフルエンザ--新型ウイルス出現と抗原変異
  喜田 宏, 動生協会々報, 32, 4, 1, 10, Oct. 1999
  動物用生物学的製剤協会, Japanese
• Detection of canine herpesvirus DNA in the ganglionic neurons and the lymph node lymphocytes of latently infected dogs
  M Miyoshi; Y Ishii; M Takiguchi; A Takada; J Yasuda; A Hashimoto; K Okazaki; H Kida, JOURNAL OF VETERINARY MEDICAL SCIENCE, 61, 4, 375, 379, Apr. 1999
  English
• 新型インフルエンザウイルスの出現メカニズムとその対策 (主題 かぜ症候群)
  喜田 宏, 小児科診療, 62, 3, 340, 345, Mar. 1999
  診断と治療社, Japanese
• 新型インフルエンザの発生メカニズムと対策 (特集 感染症研究)
  喜田 宏, 学術月報, 52, 2, 182, 187, Feb. 1999
  日本学術振興会, Japanese
• 東シベリア先住民とイヌイットから検出されたコーカソイド系JCウイルス
  杉本智恵; DEMENEV V; 関野吉晴; 本庄健男; 小嶋一男; 北村唯一; 加藤温; 喜田宏; 余郷嘉明, 日本分子生物学会年会プログラム・講演要旨集, 22nd, 1999
• インフルエンザの動物種間伝播 : 新型ウイルスの出現に果たすカモ, 家禽とブタの役割
  喜田宏, 化学療法の領域, 15, 29, 34, 1999
• インフルエンザの動物間伝搬 : 新型ウイルス出現に果たすカモ、家禽とブタの役割
  喜田宏, 化学療法の領域, 15, 1365, 1370, 1999
• The development of safety test method for the genetic recombination vaccine. (The Ministry of Health and Welfare S).
  田代真人; 板村繁之; 西村秀一; 西藤岳彦; 榎並正芳; 喜田宏, 新型インフルエンザワクチンの開発・製造・品質管理に関する研究研究報告書 平成10年度, 4, 14, 1999
  Japanese
• Rescue of transfectant influenza A virus for vaccine production against newly emerging influenza caused by H5N1 virus
  ITAMURA Shigeyuki; NISHIMURA Hidekazu; OMOE Katsuhiko; NEROME Kuniaki; UKITA Toshiyuki; KANDA Tadahito; AIZAKI Hideki; MATSUURA Yoshiharu; MIYAMURA Tatsuo; TAKEUCHI Kaoru; TANABAYASHI Kiyoshi; SAITO Takehiko; TASHIRO Masato; YAMASAKI Syudo; ENAMI Masayoshi; ENAMI Kazue; OKAZAKI Katsunori; KIDA Hiroshi, 日本分子生物学会年会プログラム・講演要旨集, 21, 0, 340, 340, 01 Dec. 1998
  Japanese
• Origin of native East Siberians as viewed from JC virus.
  SUGIMOTO Chie; DEMENEV Vladimir; HONJO Takeo; KOJUMA Kazuo; KIDA Hiroshi; KOBAYASHI Nobuyoshi; YOGO Yoshiaki, 日本分子生物学会年会プログラム・講演要旨集, 21, 0, 345, 345, 01 Dec. 1998
  Japanese
• 新型インフルエンザウイルスの出現予測と流行防止
  喜田 宏, 科学, 68, 9, 691, 699, Sep. 1998
  岩波書店, Japanese
• Detection of antibody for hemagglutinin of avian influenza virus in pig of China.
  NINOMIYA AI; YASUDA JIRO; TAKADA AYAHITO; OKAZAKI KATSUNORI; SHORTRIDGE K F; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 126th, 142, Aug. 1998
  Japanese
• Function of cattle herpesvirus 1gB glycoprotein.
  OKAZAKI KATSUNORI; FUJII SANAE; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 126th, 110, Aug. 1998
  Japanese
• Identification of the latent infected part of canine herpesvirus.
  MIYOSHI MASAHIRO; ISHII YUKI; TAKIGUCHI MITSUYOSHI; YASUDA JUN; HASHIMOTO AKIRA; TAKADA AYAHITO; OKAZAKI KATSUNORI; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 125th, 140, Mar. 1998
  Japanese
• 人獣共通伝染病・インフルエンザの疫学
  喜田 宏, 家畜診療, 414, 3, 14, Dec. 1997
  全国農業共済協会, Japanese
• Structure of the pre-early gene of canine herpesvirus.
  MIYOSHI MASAHIRO; TAKIGUCHI MITSUYOSHI; YASUDA JUN; HASHIMOTO AKIRA; OKAZAKI KATSUNORI; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 124th, 150, Sep. 1997
  Japanese
• Analysis of the intracellular invasion of cattle herpesvirus 1.
  NAGANO TOKIKO; OKAZAKI KATSUNORI; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 124th, 149, Sep. 1997
  Japanese
• Involvement of heparin-like substances in cellular infiltration process of cattle herpesvirus 1.
  OKAZAKI KATSUNORI; OTSUKA HARUKI; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 124th, 149, Sep. 1997
  Japanese
• Functional analysis of Ebola virus surface glycoprotein. Expression by plasmid and utilization of G protein deleted VSV.
  TAKADA AKIHITO; SANCHEZ A; WHITT M A; YOSHIDA HIROSHI; OKAZAKI KATSUNORI; KAWAOKA YOSHIHIRO, 日本獣医学会学術集会講演要旨集, 124th, 147, Sep. 1997
  Japanese
• Sialyl-linkage mediated selection for the appearance of host cell variants of influenza A viruses
  Y Suzuki; T Ito; H Masuda; A Takada; A Kawamoto; K Otsuki; D Miyamoto; T Suzuki; H Kida; Y Kawaoka, FASEB JOURNAL, 11, 9, A1443, A1443, Jul. 1997
  English, Summary international conference
• Laboratory of Microbiology
  KIDA Hiroshi; OKAZAKI Katsunori; TAKADA Ayato, Japanese journal of veterinary research, 45, 1, 32, 33, 30 May 1997
  北海道大学, English
• Expression of recombinant protein in mammal cell with baculovirus as a vector.
  AOKI HIROFUMI; SAKODA YOSHIHIRO; TSUCHIYA YOSHINORI; SHOJI IKUO; MATSUURA ZENJI; TAKADA AYAHITO; KIDA HIROSHI; SUGIYAMA KIMIHIRO; FUKUSHO AKIO, 日本獣医学会学術集会講演要旨集, 123rd, 153, Mar. 1997
  Japanese
• Serodiagnosis of influenza by the detection of anti-NS1 antibody.
  OZAKI KOICHI; OKAZAKI KATSUNORI; ITO TOSHIHIRO; IMAGAWA HIROSHI; SUGITA SHIGEO; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 123rd, 150, Mar. 1997
  Japanese
• Distribution of influenza virus in water bird nesting place in Siberia.
  OKAZAKI KATSUNORI; ITO TOSHIHIRO; TAKAKUWA HIROKI; IMAI MASAKI; HATTA MASATO; DEMENEV V A; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 123rd, 151, Mar. 1997
  Japanese
• インフルエンザウイルスの生態--新型ウイルスの出現に備えて
  喜田 宏, 蛋白質核酸酵素, 42, 2, 145, 153, Feb. 1997
  共立出版, Japanese
• 動物界におけるインフルエンザウイルスの生態と新型ウイルス出現のメカニズム
  喜田宏, 日本臨床, 55, 2521, 2526, 1997
• N-acetyl neuraminic acid-2,6-galactoselinkage is abundantin amnion but not in allantois of chicken eggs: Implication on efficient isolation of human influenza viruses in the former compartment and selection of egg variants
  Ito, T; Suzuki, T; Takada, A; Kawamoto, A; Otsuki, K; Masuda, H; Yamada, M; Suzuki, Y; Kida, H; Kawaoka, Y, Journal of Virology, 71, 3357, 3362, 1997
• Viral diseases of livestock in Zambia
  Aaron S. Mweene; Girja S. Pandey; Peter Sinyangwe; Andrew Nambota; Kenny Samui; Hiroshi Kida, Japanese Journal of Veterinary Research, 44, 2, 89, 105, Aug. 1996
  English, Book review
• Structure and function of influenza viruses RNA polymerase PB2.
  HATTA MASATO; MASUNAGA KENJI; ITO TOSHIHIRO; OKAZAKI KATSUNORI; TOYODA TETSUYA; ISHIHAMA AKIRA; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 122nd, 89, Aug. 1996
  Japanese
• Mechanism of infectivity neutralization of influenza virus by anti-hemagglutinin antibody.
  IMAI MASAKI; ITO TOSHIHIRO; OKAZAKI KATSUNORI; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 122nd, 88, Aug. 1996
  Japanese
• Research on infectious cattle rhinotracheitis infection prevention vaccine.
  YANO JUN; ARONMUUINE; IMAI MASAKI; OZAKI KOICHI; NAGANO TOKIKO; NINOMIYA AI; ITO TOSHIHIRO; OKAZAKI KATSUNORI; KIDA HIROSHI, 日本獣医学会学術集会講演要旨集, 122nd, 191, Aug. 1996
  Japanese
• インフルエンザA型ウイルスのシアル酸分子種に対する結合特異性と宿主粘膜表皮細胞のシアル酸組成
  堀池 剛; 鈴木 隆; 増田 裕幸; 山崎 泰広; 山田 未佳; 宮本 大誠; 木曽 真; 長谷川 明; 伊藤 壽啓; 喜田 宏; 河岡 義裕; 鈴木 康夫, 日本分子生物学会年会プログラム・講演要旨集, 19, 0, 90, 90, Aug. 1996
  Japanese
• インフルエンザウイルスの宿主変異と受容体シアロ糖鎖認識
  鈴木 康夫; 山田 未佳; 増田 裕幸; 堀池 剛; 鈴木 隆; 宮本 大誠; 木曾 真; 長谷川 明; 伊藤 壽啓; 喜田 宏; 河岡 義弘; WEBSTER R. g, 日本分子生物学会年会プログラム・講演要旨集, 19, 0, 391, 391, 01 Aug. 1996
  Japanese
• Antigenic and genetic analyses of the hemagglutinin of influenza viruses isolated from pigs in 1993
  K Katsuda; T Shirahata; H Kida; H Goto, JOURNAL OF VETERINARY MEDICAL SCIENCE, 57, 6, 1023, 1027, Dec. 1995
  English
• ウマヘルペスウイルス1型(EHV1)gC糖蛋白の細胞吸着活性
  菅原靖広; 松村富夫; 喜田宏; 岡崎克則, 日本獣医学会学術集会講演要旨集, 120th, 113, Sep. 1995
  Japanese
• BRAIN-LESIONS IN CHICKENS EXPERIMENTALLY INFECTED WITH A NEUROADAPTED STRAIN OF MESOGENIC NEWCASTLE-DISEASE VIRUS
  MI BHAIYAT; Y KOBAYASHI; C ITAKURA; MA ISLAM; H KIDA, JOURNAL OF VETERINARY MEDICAL SCIENCE, 57, 2, 237, 244, Apr. 1995
  English
• 抗血清およびアシクロビルによる新生仔犬の犬ヘルペスウイルス感染症の発病阻止効果
  浅野真知; 滝口満喜; 安田準; 橋本晃; 喜田宏; 平井克哉, 日本獣医学会学術集会講演要旨集, 119th, 235, Mar. 1995
  Japanese
• インフルエンザウイルスの起源,進化と予測
  喜田 宏, 学術月報, 47, 10, p1065, 1071, Oct. 1994
  日本学術振興会, Japanese
• PROTECTION OF MICE AGAINST AUJESZKYS-DISEASE VIRUS-INFECTION BY INTRANASAL VACCINATION WITH INACTIVATED VIRUS
  A TAKADA; Y SHIMIZU; H KIDA, JOURNAL OF VETERINARY MEDICAL SCIENCE, 56, 4, 633, 637, Aug. 1994
  English
• Pulsed intravenous methylprednisolone combined with oral steroids as the initial treatment of inflammatory myopathies
  S. Matsubara; Y. Sawa; M. Takamori; H. Yokoyama; H. Kida, Journal of Neurology, Neurosurgery and Psychiatry, 57, 8, 1008, 1994
  BMJ Publishing Group, English, Report scientific journal
• 新型インフルエンザウイルスの出現にかかわる動物とその役割 (野生動物の個体群動態と感染症<特集>)
  喜田 宏, 獣医畜産新報, 47, 1, p33, 36, Jan. 1994
  文永堂出版, Japanese
• 水禽営巣地におけるインフルエンザウイルスの存続
  喜田宏; 伊藤寿啓; 清水悠紀臣; 岡崎克則; 河岡義裕; WEBSTER R G, 日本獣医学会学術集会講演要旨集, 115th, 172, Apr. 1993
  Japanese
• 新型インフルエンザウイルスの出現機構
  喜田 宏, 化学と生物, 31, 3, 154, 162, Mar. 1993
  学会出版センタ-, Japanese
• ESTABLISHMENT OF A FELINE T-LYMPHOBLASTOID CELL-LINE SUSCEPTIBLE TO FELINE IMMUNODEFICIENCY VIRUSES
  S FUJIMOTO; M MASUDA; E ONO; H KIDA; Y SHIMIZU, MICROBIOLOGY AND IMMUNOLOGY, 37, 5, 415, 418, 1993
  English, Introduction scientific journal
• DETECTION OF FELINE HERPESVIRUS-1 TRANSCRIPTS IN TRIGEMINAL GANGLIA OF LATENTLY INFECTED CATS
  Y OHMURA; E ONO; T MATSUURA; H KIDA; Y SHIMIZU, ARCHIVES OF VIROLOGY, 129, 1-4, 341, 347, 1993
  English, Introduction scientific journal
• インフルエンザウイルスの生態--新型ウイルスの出現機構とその予測 (日本ウイルス学会シンポジウム--ウイルス学の進展--1991年)
  喜田 宏, ウイルス, 42, 1, 73, 75, Jun. 1992
  日本ウィルス学会, Japanese
• 北方圏の水禽営巣地点におけるインフルエンザウイルスおよびパラミクソウイルスの分布‐1991年
  伊藤寿啓; 岡崎克則; 河岡義裕; 小野悦郎; 清水悠紀臣; WEBSTER R G; 喜田宏, 日本獣医学会学術集会講演要旨集, 113th, 176, Apr. 1992
  Japanese
• ANTIBODY-RESPONSES OF SWINE TO TYPE-A INFLUENZA-VIRUSES IN THE MOST RECENT SEVERAL YEARS
  H GOTO; M TAKAI; H IGUCHI; W BENKELE; C OHTA; Y YAMAMOTO; H KIDA; S NORO; N SAKURADA, JOURNAL OF VETERINARY MEDICAL SCIENCE, 54, 2, 235, 241, Apr. 1992
  English
• THE EFFECT OF EXPERIMENTAL-INFECTION OF MOUSE PREIMPLANTATION EMBRYOS WITH PARAMYXO-VIRUS SENDAI
  C LAVILLAAPELO; H KIDA; H KANAGAWA, JOURNAL OF VETERINARY MEDICAL SCIENCE, 54, 2, 335, 340, Apr. 1992
  English
• Enhancement of intestinal immunity of domestic animals.
  Shimizu Y; Kida H; Ito T, Rep. Ito. Mem. Found., 9, 61, 65, 1991
  English
• ウイルス性呼吸器病の新しいワクチン (肺疾患への新しいアプロ-チ<特集>)
  喜田 宏, 獣医畜産新報, 43, 6, p343, 346, Jun. 1990
  文永堂出版, Japanese
• CLONING AND EXPRESSION OF A PILI GENE OF CORYNEBACTERIUM-RENALE IN ESCHERICHIA-COLI
  S ABE; T SAITO; T KOGA; E ONO; R YANAGAWA; T ITO; H KIDA; Y SHIMIZU, JAPANESE JOURNAL OF VETERINARY SCIENCE, 52, 1, 11, 18, Feb. 1990
  English
• Enhancement of intestinal immunity of domestic animals.
  Shimizu Y; Kida H; Ito T, Rep. Ito. Mem. Found., 8, 74, 78, 1990
  English
• Nature of renal involvement in the acro-renal-ocular syndrome
  T. Naito; H. Kida; H. Yokoyama; T. Abe; S. Takeda; D. Uno; N. Hattori, Nephron, 51, 1, 115, 118, 1989
  English, Book review
• BIOLOGICAL-ACTIVITIES OF MONOCLONAL-ANTIBODIES TO THE HEMAGGLUTININ-NEURAMINIDASE (HN) PROTEIN OF NEWCASTLE-DISEASE VIRUS
  GB ABENES; H KIDA; R YANAGAWA, JAPANESE JOURNAL OF VETERINARY SCIENCE, 48, 2, 353, 362, Apr. 1986
  English
• 鳥類インフルエンザウイルス
  喜田 宏, ウイルス, 34, 2, 109, 119, Dec. 1984
  日本ウィルス学会, Japanese
• 鳥類パラミクソウイルスの分類
  喜田 宏, 日本獣医師会雑誌, 36, 2, p55, 61, Feb. 1983
  日本獸医師会, Japanese
• AVIAN PARAMYXOVIRUSES POSSESSING ANTIGENICALLY RELATED HN BUT DISTINCT M-PROTEINS
  GB ABENES; H KIDA; R YANAGAWA, ARCHIVES OF VIROLOGY, 77, 1, 71, 76, 1983
  English, Introduction scientific journal
• LEPTOSPIRA-INTERROGANS SEROVAR HARDJO INFECTION IN COWS OF HOKKAIDO, JAPAN - SEROLOGICAL EVIDENCE
  M TSUCHIMOTO; H KIDA; R YANAGAWA; S INUI, JAPANESE JOURNAL OF VETERINARY SCIENCE, 45, 6, 811, 814, 1983
  English, Introduction scientific journal
• AN AVIAN INFLUENZA-VIRUS OF WHICH INFECTIVITY IS NEUTRALIZED BY ANTISERA LACKING HEMAGGLUTINATION-INHIBITION ACTIVITY
  S YODEN; H KIDA; R YANAGAWA, ARCHIVES OF VIROLOGY, 74, 2-3, 205, 210, 1982
  English, Introduction scientific journal
• HOST SPECIES-RELATED ANTIGENIC GROUPS OF AVIAN INFLUENZA-VIRUSES POSSESSING H-4 HEMAGGLUTININ REVEALED BY MONOCLONAL-ANTIBODIES
  H FUKUSHI; R YANAGAWA; H KIDA, ARCHIVES OF VIROLOGY, 72, 3, 217, 221, 1982
  English, Introduction scientific journal
• ISOLATION AND IDENTIFICATION OF PARAMYXOVIRUSES FROM JAPANESE BUNTINGS (EMBERIZA-SPODOCEPHALA) AND DUCKS (ANAS-CRECCA AND ANAS-PENELOPE)
  H KIDA; E HONDA; R YANAGAWA; Y MATSUURA; Y KAWAOKA; S TAKAI; E ISOGAI; C OTA, JAPANESE JOURNAL OF VETERINARY SCIENCE, 44, 2, 317, &, 1982
  English
• SEROLOGICAL SURVEY OF INFLUENZA-A VIRUS-INFECTION IN MINK
  K YAGYU; R YANAGAWA; Y MATSUURA; H FUKUSHI; H KIDA; H NODA, JAPANESE JOURNAL OF VETERINARY SCIENCE, 44, 4, 691, 693, 1982
  English, Introduction scientific journal
• ISOLATION OF ORTHOMYXOVIRUSES AND PARAMYXOVIRUSES FROM FERAL BIRDS IN HOKKAIDO, JAPAN 1980 AND 1981
  GB ABENES; K OKAZAKI; H FUKUSHI; H KIDA; E HONDA; K YAGYU; M TSUJI; H SATO; E ONO; R YANAGAWA; N YAMAUCHI, JAPANESE JOURNAL OF VETERINARY SCIENCE, 44, 5, 703, 708, 1982
  English
• A NEW PARAMYXOVIRUS ISOLATED FROM AN AMADUVADE FINCH (ESTRILDA-AMANDAVA)
  Y MATSUOKA; H KIDA; R YANAGAWA, JAPANESE JOURNAL OF VETERINARY SCIENCE, 42, 2, 161, 167, 1980
  English
• Distribution of Antibodies against Various Influenza A Viruses in Animals
  ONTA Tokio; KIDA Hiroshi; KAWANO Jun-ichi; MATSUOKA Yumiko; YANAGAWA Ryo, The Japanese journal of veterinary science, 40, 4, 451, 454, 25 Aug. 1978
  Japanese Society of Veterinary Science, English
• インフルエンザウイルスに対するγ-Inhibitorの加熱による活性化の機序
  喜田 宏, 医学と生物学, 88, 2, 79, 84, Feb. 1974
  緒方医学化学研究所医学生物学速報会