Researcher basic information

• Ph.D., Hokkaido University, Mar. 2013

• https://researchmap.jp/kenji-imamachi?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202101013940984180
• https://orcid.org/0000-0003-1090-3660

• https://orcid.org/0000-0003-1090-3660

• 202101013940984180

• がん支持療法 医科歯科連携

• Life Science, Surgical dentistry

• Bachelor's degree program, School of Dental Medicine
• Doctoral (PhD) degree program, Graduate school of Dental Medicine

Research activity information

• Efficacy and risks of drug holiday in the management of medication-related osteonecrosis of the jaw in cancer patients: a single-center retrospective study
  Hironobu Hata; Kenji Imamachi; Kazuhito Yoshikawa; Mayumi Kamaguchi; Toshihisa Osanai; Masashi Matsuzaka; Kenichi Watanabe; Nobumoto Tomioka; Toru Harabayashi; Katsuya Fujimoto; Satoshi Oizumi; Michihiro Ueda; Hiroaki Hiraga; Ikuya Miyamoto
  Supportive Care in Cancer, Feb. 2026
  Scientific journal
• がんMRONJ外来の開設 歯科のないがん診療病院との連携に向けて
  秦 浩信; 鎌口 真由美; 江戸 美奈子; 圖司 陽子; 森 麻葉; 宮本 亜有美; 遠藤 紗枝; 國井 信彦; 吉谷 夏純; 今待 賢治; 吉川 和人
  国立病院総合医学会講演抄録集, 79回, 551, 551, 国立病院総合医学会, Nov. 2025
  Japanese
• Investigation of the minimum uptake time for quantitative jawbone SPECT.
  Hironobu Hata; Kenji Hirata; Satoshi Shimomura; Kenji Imamachi; Takuya Asaka; Mayumi Kamaguchi; Kenta Miwa; Masashi Matsuzaka; Yoichi Mori; Toshikazu Nambu
  BMC oral health, 25, 1, 1611, 1611, 14 Oct. 2025, [International Magazine]
  English, Scientific journal, BACKGROUND: The range of imaging times recommended for bone scintigraphy is wide, and uptake times vary across facilities. In our previous quantitative evaluation of jawbone SPECT using [99mTc] Tc-HMDP, we reported that standardized uptake values at the 2-hour uptake time were comparable to those at the 3-hour uptake time. A reduction in the uptake time is of particular benefit to patients with poor general health conditions, such as those suffering from cancer. This study aimed to conduct additional research based on the hypothesis that further reduction of uptake time may be possible. METHODS: Forty patients scheduled for jawbone SPECT at our hospital's Department of Dentistry and Oral Surgery were enrolled in this study and assigned to two groups. The 1.0-hour uptake time group was imaged at two time points, 1.0 and 2.0 h, and the 1.5-hour uptake time group was imaged at two time points, 1.5 and 2.0 h, for jawbone lesions and parietal bone. We investigated statistically significant differences by comparing the maximum standardized uptake values (SUVmax) for each of the two groups using quantitative SPECT software. RESULTS: When the SUVmax of the 1.0-hour uptake time group was compared, the median SUVmax of the parietal bone was not significantly different. In contrast, the median SUVmax of jawbone lesions significantly increased to 6.40 and 8.10, respectively (p < 0.001). Similarly, in the 1.5-hour uptake time group, the median SUVmax of the parietal bone was not significantly different. The median SUVmax of the jawbone lesions increased to 7.22 and 8.03, respectively, with a statistically significant difference (p < 0.001). CONCLUSIONS: The uptake time required for quantitative SPECT evaluation of jawbone lesions using [99mTc] Tc-HMDP could not be further reduced from 2 h in 30-minute increments, and the shortest acceptable acquisition time for quantitative jawbone SPECT was 2 h.
• 下歯槽動脈への経カテーテル動脈塞栓術を併用して抜歯を施行した巨大動静脈奇形の1例
  今待 賢治; 佐藤 明; 秦 浩信; 金山 純一; 高橋 浩師; 北川 善政
  日本口腔外科学会雑誌, 71, 10, 464, 470, (公社)日本口腔外科学会, Oct. 2025
  Japanese
• ステロイド全身投与を要した免疫チェックポイント阻害薬による重症口腔粘膜炎の2例
  鎌口 真由美; 江戸 美奈子; 今待 賢治; 吉谷 夏純; 吉川 和人; 秦 浩信
  日本口腔科学会雑誌, 74, 3, 213, 213, (NPO)日本口腔科学会, Sep. 2025
  Japanese
• 迷走神経上神経節ならびに下神経節における温度センサーの分布
  佐藤 匡; 今待 賢治; 矢島 健大; 高橋 茂
  北海道歯学雑誌, 46, 14, 17, 北海道歯学会, Sep. 2025
  Japanese
• Distribution and possible function of transient receptor potential melastatin-7 in the rat cranial sensory ganglia.
  Hiroka Tsumaki; Tomohiro Fukunaga; Kaori Takahashi; Takehiro Yajima; Kenji Imamachi; Yuji Hatakeyama; Hiroyasu Kanetaka; Shigeru Takahashi; Tadasu Sato
  Biomedical research (Tokyo, Japan), 46, 5, 215, 224, 2025, [Domestic magazines]
  English, Scientific journal, The distribution of transient receptor potential melastatin 7 (TRPM7) was investigated in the trigeminal (TG), petrosal (PG), jugular (JG), and nodose ganglia (NG) in a rat model. Approximately half of the sensory neurons contained TRPM7-immunoreactivity in the TG, PG, JG, and NG. TRPM7-immunoreactive (-IR) sensory neurons had small- to medium-sized cell bodies. Triple immunofluorescence analysis revealed that TRPM7-IR sensory neurons showed mainly transient receptor potential vanilloid 1 (TRPV1) immunoreactivity, whereas less than 10% of TRPM7-IR neurons contained TRPV2-immunoreactivity. In the facial skin, some nerve fibers contained TRPM7-immunoreactivity and formed free nerve endings. Using a retrograde tracing method, 56% of cutaneous TG neurons contained TRPM7-immunoreactivity. Approximately half of TRPM7-IR cutaneous TG neurons contained TRPV1-immunoreactivity. Approximately two-thirds of PG, JG, and NG neurons innervating the external ear canal skin contained TRPM7-immunoreactivity. Most TRPM7-IR cutaneous PG, JG, and NG neurons contained TRPV1-immunoreactivity. However, TRPM7-IR neurons that innervate the tooth pulp and pharynx are relatively rare. This study suggests that the distribution of TRPM7 depends on the size of nerve cells and peripheral innervation. TRPM7 may be involved in pain sensation in the trigeminal, glossopharyngeal, and vagal ganglia sensory neurons.
• Apoptotic cell death during regressive changes in salivary glands: A morphological perspective
  Shigeru Takahashi; Akihiro Nezu; Akihiko Tanimura; Chikage Tamura; Kenji Imamachi; Tadasu Sato
  Journal of Oral Biosciences, Nov. 2024
  Scientific journal
• 診断に苦慮した口腔病変を伴ったクローン病の1例
  坂田 健一郎; 徳永 貴亮; 今待 賢治; 志村 拓海; 木村 拓; 松田 彩; 佐藤 明; 佐藤 淳; 北川 善政
  北海道歯学雑誌, 45, 69, 75, 北海道歯学会, Sep. 2024
  Japanese
• 診断に苦慮した口腔病変を伴ったクローン病の1例
  坂田 健一郎; 徳永 貴亮; 今待 賢治; 志村 拓海; 木村 拓; 松田 彩; 佐藤 明; 佐藤 淳; 北川 善政
  北海道歯学雑誌, 45, 69, 75, 北海道歯学会, Sep. 2024
  Japanese
• Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional study.
  Hironobu Hata; Satoshi Shimomura; Kenji Imamachi; Jun Sato; Takuya Asaka; Kenji Hirata; Kyousuke Funayama; Yoichi Mori; Masashi Matsuzaka; Toshikazu Nambu; Yoshimasa Kitagawa
  BMC oral health, 24, 1, 305, 305, 05 Mar. 2024, [International Magazine]
  English, Scientific journal, BACKGROUND: The long time required for bone uptake of radiopharmaceutical material after injection for bone scintigraphy is a burden for patients with poor health. Thus, to assess whether the uptake time could be reduced for single-photon emission computed tomography (SPECT) of the jawbone, this study evaluated differences in maximum standardized uptake values (SUVmax) within patients using SPECT imaging at 2 and 3 hours after radiopharmaceutical injection. METHODS: A total of 33 patients undergoing treatment or in post-treatment follow-up for medication-related osteonecrosis of the jaw, who visited our hospital between July 2020 and August 2021 and could receive SPECT twice on the same day, were enrolled in the study. Patients were injected with technetium-99 m hydroxymethylene diphosphonate (Tc-99 m HMDP) intravenously. The SUVmax for healthy parietal bones and jawbone lesions were calculated from the SPECT images using quantitative analysis software, and the SUVmax were compared between 2- and 3-hour uptake times. RESULTS: After exclusion, 30 patients were included in the study. In the 2-hour and 3-hour images, the median SUVmax of the parietal bones were 1.90 and 1.81, respectively, and those of the jawbone lesions were 9.25 and 9.39, respectively. The limits of agreement (LOA) ranged from - 0.33 to 0.25 in the parietal bones, and the %LOA ranged from - 9.8 to 17.3% in the jawbone lesions, showing high equivalence between the two uptake durations. The SUVmax showed no clinical differences between the 2- and 3-hour uptake durations for Tc-99 m HMDP SPECT of the jawbone. CONCLUSIONS: The results of this study justify a 2-3-hour uptake window when performing quantitative SPECT of the jawbone. Therefore, the minimum uptake time can potentially be reduced to only 2 hours.
• Osteoradionecrosis of the jaw suspicious of correlation with bone-modifying agent treatment: A case report
  Taku Kimura; Ken-ichiro Sakata; Kenji Imamachi; Yoshimasa Kitagawa
  Medicine: Case Reports and Study Protocols, Jan. 2024, [Peer-reviewed]
  English
• 北海道がんセンターにおけるがん診療医科歯科前連携システムの実績
  今待 賢治; 江戸 美奈子; 前田 豪樹; 平賀 博明; 秦 浩信
  日本医療マネジメント学会雑誌, 24, 3, 162, 169, (NPO)日本医療マネジメント学会, Dec. 2023
  Japanese
• Immunohistochemical investigation of nerve distribution in mature parotid and submandibular glands of rats with a liquid diet.
  Shigeru Takahashi; Chikage Tamura; Yoshiyuki Nakamichi; Kenji Imamachi; Tsuneyuki Yamamoto
  Folia morphologica, 25 Aug. 2023, [International Magazine]
  English, Scientific journal, BACKGROUND: Although feeding with a liquid diet does not affect the growth of rat submandibular glands, it inhibits the growth of rat parotid glands during growth periods. In these growth-inhibited parotid glands, the growth of parasympathetic nerves is also suppressed. Meanwhile, the mature parotid glands of animals maintained on a liquid diet become morphologically and functionally atrophic, however, there is no effect of a liquid diet on mature submandibular glands. The objective of the present study was to clarify whether the nerve distribution in the mature salivary glands of rats was affected by a liquid diet. MATERIALS AND METHODS: Seven-week-old male Wistar rats were used in this study. Half of the rats were kept on a pellet diet, and half were kept on a liquid diet, for 3, 7, 14, or 21 days. All rats were euthanised by isoflurane at each endpoint. Then, the parotid and submandibular glands were removed, frozen in liquid nitrogen, cryosectioned, and stained with antibodies against protein gene product 9.5 (PGP 9.5; general nerve marker), tyrosine hydroxylase (TH; sympathetic nerve marker), or neuronal nitric oxide synthase (nNOS; parasympathetic nerve marker). RESULTS: In parotid and submandibular glands of the pellet diet group, PGP 9.5- and TH-like immunoreactivity were seen around acini and ducts, and nNOS-like immunoreactivity was lower than PGP 9.5- and TH-like immunoreactivity. In the parotid glands of the liquid diet group, similar immunoreactivities were seen throughout the experimental period. The distribution of antibody labelling in the submandibular glands of the liquid diet group was similar to that of the pellet diet group and remained unchanged during the experimental period. CONCLUSIONS: The present study demonstrated no regressive effects of a liquid diet on the distribution of sympathetic or parasympathetic nerves in mature parotid glands and submandibular glands. This differed from inhibitory effects on the growth of parotid glands seen during growth periods.
• がん診療医科歯科前連携システムにおける歯科衛生士の役割
  江戸 美奈子; 今待 賢治; 圖司 陽子; 宮本 亜有美; 秦 浩信; 北海道歯科衛生士会
  日本歯科衛生学会雑誌, 17, 2, 99, 107, 日本歯科衛生学会, Feb. 2023
  Japanese
• Response to: Prognosis of metastatic bone cancer and myeloma patients and long‑term risk of medication‑related osteonecrosis of the jaw (MRONJ): some critical points.
  Hironobu Hata; Kenji Imamachi; Michihiro Ueda; Masashi Matsuzaka; Hiroaki Hiraga; Toshihisa Osanai; Toru Harabayashi; Katsuya Fujimoto; Satoshi Oizumi; Masato Takahashi; Kazuhito Yoshikawa; Jun Sato; Yutaka Yamazaki; Yoshimasa Kitagawa
  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 30, 12, 9693, 9695, Dec. 2022, [International Magazine]
  English
• Prognosis by cancer type and incidence of zoledronic acid-related osteonecrosis of the jaw: a single-center retrospective study.
  Hironobu Hata; Kenji Imamachi; Michihiro Ueda; Masashi Matsuzaka; Hiroaki Hiraga; Toshihisa Osanai; Toru Harabayashi; Katsuya Fujimoto; Satoshi Oizumi; Masato Takahashi; Kazuhito Yoshikawa; Jun Sato; Yutaka Yamazaki; Yoshimasa Kitagawa
  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 30, 5, 4505, 4514, May 2022, [International Magazine]
  English, Scientific journal, PURPOSE: Survival time after bisphosphonate use has been increasingly recognized to be associated with the incidence of medication-related osteonecrosis of the jaw (MRONJ); however, this has not been elucidated sufficiently in the literature. This study aimed to clarify the incidence of MRONJ and the corresponding survival rate of patients treated with zoledronic acid (ZA) for each type of cancer and obtain useful information for the oral/dental supportive care of cancer patients. METHODS: We evaluated 988 patients who were administered ZA at our hospital; among them, 862 patients with metastatic bone tumors or myeloma were included. RESULTS: The median survival time (MST) after ZA initiation was 35, 34, 8, 41, 12, and 6 months for patients with breast, prostrate, lung, myeloma, renal, and other cancers, respectively. Patients with cancers that had a short survival time (lung and other cancers [MST = 8 and 6 months, respectively] and cancers with MST < 10 months) did not develop MRONJ; this could be attributed to the shorter duration of ZA administration. The cumulative incidence of MRONJ in breast cancer, prostate cancer, and multiple myeloma was related to the frequency of anti-resorptive drug use and the increased risk over time. In renal cancer, the cumulative incidence of MRONJ increased early, although the MST was 12 months. CONCLUSION: For the dentists in charge of dental management, it is essential to be aware of prognosis-related factors, predict MRONJ risk for each cancer treatment, and use risk prediction in dental management planning, particularly for cancers with non-poor prognosis.
• Oral adverse events due to zinc deficiency after pancreaticoduodenectomy requiring continuous intravenous zinc supplementation: a case report and literature review.
  Hironobu Hata; Yojiro Ota; Katsuhiko Uesaka; Yutaka Yamazaki; Tsubasa Murata; Chika Murai; Kazuhito Yoshikawa; Kenji Imamachi; Takashi Yurikusa; Yoshimasa Kitagawa
  BMC oral health, 22, 1, 52, 52, 03 Mar. 2022, [International Magazine]
  English, Scientific journal, BACKGROUND: Zinc is mainly absorbed in the duodenum and proximal jejunum, which are removed during pancreaticoduodenectomy (PD). Little is known about the adverse oral events and skin disorders caused by zinc deficiency after PD. Herein, we reviewed studies on the development of zinc deficiency after PD and reported about a patient with zinc deficiency after PD who required home intravenous zinc replacement. CASE PRESENTATION: A 73-year-old woman with glossitis, taste disorder, and acrodermatitis enteropathica-like eruption on her fingers presented to the Division of Dentistry and Oral Surgery 69 days after PD. Her serum zinc level markedly decreased to 30 μg/dL. Oral zinc administration was inadequate to treat hypozincemia after PD; therefore, multi-trace elements were injected intravenously during readmission. Her serum zinc levels recovered, and her lesions gradually improved. Furthermore, a central venous port was implanted to maintain normal serum zinc levels, and she continued self-injecting zinc at home. CONCLUSIONS: Zinc deficiency after PD rarely occurs. The clinical oncologist community, including dentists responsible for the oral care of cancer patients, should be aware of the oral adverse events, such as dysgeusia, glossitis, and oral pain, associated with zinc deficiency after cancer surgery and that induced by chemotherapy or head and neck radiation therapy.
• Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study.
  Hironobu Hata; Shinya Takada; Jun Sato; Kazuhito Yoshikawa; Kenji Imamachi; Minako Edo; Tamotsu Sagawa; Koshi Fujikawa; Michihiro Ueda; Masashi Matsuzaka; Yoshimasa Kitagawa
  Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, 41, 4, 498, 504, Jul. 2021, [International Magazine]
  English, Scientific journal, AIMS: Symptomatic treatment is insufficient for chemotherapy- or targeted therapy-induced oral mucositis (OM) pain, and benzydamine mouthwash is not commercially available in Japan. We evaluated the analgesic effects of an in-hospital preparation of 0.25% indomethacin spray (IMS) on anticancer drug-induced OM pain. METHODS: This single-arm prospective trial enrolled 20 patients (median age 62.0 years) with OM and numerical rating scale scores of ≥5 who were undergoing chemotherapy or targeted therapy in our hospital. Pain scores were recorded using a visual analog scale (VAS) before and 30 min after IMS administration. Pain relief (PR) scores were recorded at 15, 30, and 60 min after IMS administration; total PR after 60 min (TOTPAR60 ) was calculated, and the mean PR score after 3 days (PR3days ) was determined. RESULTS: The median (interquartile range) OM grade of the participants was 2.0 (2.0-2.3). The VAS score decreased significantly at 30 min after IMS administration (p = .001). The median (interquartile range) TOTPAR60 and PR3days were 6.0 (3.8-7.3) and 2.0 (2.0-3.0), respectively. CONCLUSIONS: IMS helped improve patients' quality of life. The risk of systemic adverse effects was low because of the low dose administered. IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication.
• 認知症の高齢乳癌患者に生じたARONJの1例
  今待 賢治; 秦 浩信; 鎌口 真由美; 北川 善政
  日本口腔内科学会雑誌, 27, 1, 21, 25, (一社)日本口腔内科学会, Jun. 2021
  Japanese
• Quantitative bone single photon emission computed tomography analysis of the effects of duration of bisphosphonate administration on the parietal bone.
  Hironobu Hata; Tomoka Kitao; Jun Sato; Takuya Asaka; Kenji Imamachi; Masaaki Miyakoshi; Kenji Hirata; Keiichi Magota; Yamato Munakata; Tohru Shiga; Yutaka Yamazaki; Yoshimasa Kitagawa
  Scientific reports, 10, 1, 17461, 17461, 15 Oct. 2020, [International Magazine]
  English, Scientific journal, Effects of long-term bisphosphonate (BP) administration on the metabolism of healthy bone and the concomitant changes in imaging are unclear. Hence, we aimed to retrospectively investigate the effects of long-term BP administration on the intact parietal bone using the standardised uptake value (SUV) derived from single photon emission computed tomography (SPECT). We enrolled 29 patients who had odontogenic infection, osteoporosis, bone metastasis cancer, or rheumatoid arthritis, and classified them into BP-naïve: A (14 patients) and BP-treated: B, < 4 years (7 patients) and C, ≥ 4 years (8 patients) groups. We measured the maximum bilateral SUV (SUVmax) of the parietal bone using quantitative bone SPECT software. There were significant differences in the duration of BP administration and SUVmax of the parietal bone among the diseases (P < 0.0001 and P = 0.0086, respectively). There was a positive correlation between the duration of BP administration and SUVmax of the parietal bone (rs = 0.65, P = 0.0002). The SUVmax was significantly different between A and B (P = 0.02) and between A and C (P = 0.0024) groups. This is the first report on the correlation between long-term BP administration and the SUVmax of the parietal bone using the quantitative bone SPECT analysis.
• Monitoring indices of bone inflammatory activity of the jaw using SPECT bone scintigraphy: a study of ARONJ patients.
  Hironobu Hata; Tomoka Kitao; Jun Sato; Takuya Asaka; Noritaka Ohga; Kenji Imamachi; Kenji Hirata; Tohru Shiga; Yutaka Yamazaki; Yoshimasa Kitagawa
  Scientific reports, 10, 1, 11385, 11385, 09 Jul. 2020, [International Magazine]
  English, Scientific journal, Development of quantitative analysis software has enabled application of several standardised uptake values (SUV) for bone analysis in single photon emission computed tomography (SPECT). The present retrospective study aimed to develop a reliable method of monitoring bone inflammatory activity in antiresorptive agent-related osteonecrosis of the jaw (ARONJ) using SPECT quantitative analysis software. Fifteen ARONJ patients underwent SPECT before and after anti-inflammatory therapy. We calculated the mean maximum SUV (SUVmax) of the bilateral cranial bones using quantitative analysis software and used this as the control [C]. We attempted to adjust the SUVmax of the lesion [L] as follows: adjusted SUVmax (aSUVmax) = [L] - [C]. The optimum threshold to calculate the metabolic bone volume (MBV) (cm3) was [C] + 3. The threshold values obtained for each case were input to calculate MBV at each osteomyelitis site. Retrospectively, we compared aSUVmax and MBV of each patient's ARONJ before and after anti-inflammatory therapy. The patients' high aSUVmax or large MBV of the ARONJ reduced rapidly, reflecting individual clinical findings after treatment. Application of SPECT quantitative analysis software to monitor bone inflammatory activity in ARONJ could improve the prognosis-deciding abilities of clinicians and enable them to treat ARONJ effectively.
• 口腔癌患者における術後せん妄発症のリスク因子に関する後向き調査研究 E-PASSの有用性について
  坪井 香奈子; 佐藤 明; 黒嶋 雄志; 今待 賢治; 吉川 和人; 宮腰 昌明; 北川 善政
  日本口腔外科学会雑誌, 65, 7, 440, 446, (公社)日本口腔外科学会, Jul. 2019
  Japanese, 当科で経験した術後せん妄のリスク因子について検討するとともに、口腔癌手術においてE-PASS(estimation of physiologic ability and surgical stress)を応用し、せん妄発症の予測因子としての有用性について検討した。2010年1月～2017年5月に当科で口腔癌の手術を行った134名を対象とし、そのうち28名は2回以上の手術歴を有していたため1手術1例と考え合計164例とした。術後せん妄は164例中14例(8.5%)に発症した。せん妄発症の術前リスク因子ではBenzodiazepine(BZ)系薬服用歴と糖尿病で有意差を認め、手術に関するリスク因子では手術時間、出血量、気管切開術が、術後リスク因子では頸部ドレーンの留置と術後Alb値が抽出された。単変量解析で有意差を認めた術前リスク因子のうち、E-PASSの術前評価項目である術前リスクスコア(PRS)とE-PASSの構成要素に含まれていない術前リスク因子であるBZ系薬剤服用歴の2項目を説明変数とし多変量解析を行った結果、BZ系薬剤服用歴とPRS>0.36のそれぞれが独立したリスク因子であった。
• がん診療医科歯科前連携システム構築に向けた取り組み
  秦 浩信; 江戸 美奈子; 今待 賢治; 渡邊 健一; 菊地 久美子; 加藤 秀則
  日本医療マネジメント学会雑誌, 20, 1, 19, 26, (NPO)日本医療マネジメント学会, Jun. 2019
  Japanese
• 骨SPECT定量解析ソフトウェアにより顎骨骨髄炎のモニタリングを行った1例
  秦 浩信; 北尾 友香; 今待 賢治; 浅香 卓哉; 山崎 裕; 北川 善政
  日本口腔科学会雑誌, 68, 1, 38, 44, (NPO)日本口腔科学会, Mar. 2019
  Japanese
• 口腔癌に対する免疫チェックポイント阻害剤投与の実際と腫瘍内科医との連携 口腔癌に対する免疫療法 腫瘍内科との連携
  上田 倫弘; 林 信; 新山 宗; 秦 浩信; 今待 賢治
  日本口腔腫瘍学会誌, 30, 4, 135, 143, (一社)日本口腔腫瘍学会, Dec. 2018
  Japanese
• 頭頸部癌患者の口腔支持療法と地域連携
  秦 浩信; 吉川 和人; 今待 賢治; 村井 知佳; 上田 倫弘; 永橋 立望; 西山 典明; 安田 耕一; 本間 明宏; 北川 善政
  頭頸部癌, 44, 4, 380, 386, (一社)日本頭頸部癌学会, Dec. 2018
  Japanese
• 「周術期口腔機能管理(がん口腔支持療法)のこれから」 周術期口腔機能管理(がん支持療法)のこれから 都道府県がん診療連携拠点病院 がん専門病院歯科の立場から
  秦 浩信; 今待 賢治; 新山 宗; 林 信; 上田 倫弘
  日本口腔腫瘍学会誌, 30, 3, 80, 84, (一社)日本口腔腫瘍学会, Sep. 2018
  Japanese
• Quality of Survivalを考慮した頭頸部癌支持療法 頭頸部がん患者の口腔支持療法と地域連携
  秦 浩信; 吉川 和人; 今待 賢治; 上田 倫弘; 永橋 立望; 西山 典明; 安田 耕一; 本間 明宏; 北川 善政
  頭頸部癌, 44, 2, 115, 115, (一社)日本頭頸部癌学会, May 2018
  Japanese
• Regional dental cooperation and oral supportive care for head and neck cancer patients
  Hironobu Hata; Kazuhito Yoshikawa; Kenji Imamachi; Chika Murai; Michihiro Ueda; Tatsumi Nagahashi; Noriaki Nishiyama; Kouichi Yasuda; Akihiro Honma; Yoshimasa Kitagawa
  Japanese Journal of Head and Neck Cancer, 44, 4, 380, 386, 2018
  Scientific journal
• pp32r1 controls the decay of the RNA-binding protein HuR.
  Kenji Imamachi; Fumihiro Higashino; Tetsuya Kitamura; Wataru Kakuguchi; Aya Yanagawa-Matsuda; Makoto Ishikawa; Yoshimasa Kitagawa; Yasunori Totsuka; Masanobu Shindoh
  Oncology reports, 31, 3, 1103, 8, Mar. 2014, [International Magazine]
  English, Scientific journal, pp32 is a tumor suppressor and is one of the associated proteins of the RNA-binding protein HuR. The pp32-HuR complex is exported to the cytoplasm of cells under stress conditions, and HuR is degraded by caspases in the cytoplasm. In the present study, we examined the role of pp32r1, a member of the pp32 family that has oncogenic properties, in the decay of HuR. pp32r1 was found to be abundantly expressed in cancer cells, and overexpression of pp32r1 induced colony formation in soft-agar. pp32r1 was expressed in both the nucleus and cytoplasm, whereas pp32 was predominantly localized in the nucleus. Even with lethal stress such as staurosporine (STS), HuR in the cytoplasm was never downregulated, and caspase-3 activity was inhibited when cells expressed pp32r1. pp32r1 bound to HuR without interacting with pp32. In cancer cells, HuR survived in the cytoplasm of cells overexpressing pp32r1, although HuR was not expressed in the cytoplasm of pp32-expressing cells, similar to lethal stress conditions. Taken together, these results indicate that pp32r1 binds to HuR to avoid the caspase-mediated decay of HuR in the cytoplasm of cells. We suggest that this function contributes to the oncogenic activity of pp32r1.
• Difficulty in diagnosis of tetanus in Japan: Report of a case and review of the literature
  Takehiko Satoh; Jun Sato; Takahiro Abe; Akira Satoh; Kenji Imamachi; Yoshimasa Kitagawa
  JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 25, 1, 55, 60, Jan. 2013
  English
• 頭頸部癌患者を支えるチーム医療 北海道大学病院の頭頸部がん患者に対する口腔ケアの取り組み
  秦 浩信; 山崎 裕; 今待 賢治; 村井 知佳; 佐藤 淳; 水町 貴諭; 加納 里志; 本間 明宏; 福田 諭; 北川 善政
  頭頸部癌, 37, 4, 486, 493, (一社)日本頭頸部癌学会, Dec. 2011
  Japanese

• ステロイド全身投与を要した免疫チェックポイント阻害薬による重症口腔粘膜炎の2例
  鎌口 真由美; 江戸 美奈子; 今待 賢治; 吉谷 夏純; 吉川 和人; 秦 浩信, 日本口腔科学会雑誌, 74, 3, 213, 213, Sep. 2025
  (NPO)日本口腔科学会, Japanese
• 中咽頭扁平上皮癌における放射線性顎骨壊死の臨床的検討
  吉川 和人; 今待 賢治; 浅香 卓哉, 頭頸部癌, 51, 2, 162, 162, May 2025
  (一社)日本頭頸部癌学会, Japanese
• 当院で施行した鼻副鼻腔悪性腫瘍放射線治療の口腔管理における臨床的検討
  今待 賢治; 吉川 和人; 浅香 卓哉, 頭頸部癌, 51, 2, 230, 230, May 2025
  (一社)日本頭頸部癌学会, Japanese
• ステロイドの全身投与を要したニボルマブによる重症口腔粘膜炎の1例
  秦 浩信; 鎌口 真由美; 江戸 美奈子; 圖司 陽子; 森 麻葉; 宮本 亜有美; 遠藤 紗枝; 國井 信彦; 今待 賢治; 和田 麻友美; 吉川 和人, 国立病院総合医学会講演抄録集, 78回, O2, 2, Oct. 2024
  国立病院総合医学会, Japanese
• ステロイドの全身投与を要したニボルマブによる重症口腔粘膜炎の1例
  秦 浩信; 鎌口 真由美; 江戸 美奈子; 圖司 陽子; 森 麻葉; 宮本 亜有美; 遠藤 紗枝; 國井 信彦; 今待 賢治; 和田 麻友美; 吉川 和人, 国立病院総合医学会講演抄録集, 78回, O2, 2, Oct. 2024
  国立病院総合医学会, Japanese
• HBO単独あるいはHBOと低侵襲手術の併用が奏功した高齢者MRONJの3例
  木村 拓; 草野 圭佑; 大藏 太郎; 坂田 健一郎; 佐藤 淳; 浅香 卓哉; 今待 賢治; 北川 善政, 日本口腔科学会雑誌, 73, 2, 133, 134, Sep. 2024
  (NPO)日本口腔科学会, Japanese
• 長期生存乳癌患者の薬剤関連顎骨壊死に対して腐骨上義歯により口腔機能維持を目指した2例
  國井 信彦; 小野木 宏仲; 佐々木 敏博; 今待 賢治; 秦 浩信, 日本口腔リハビリテーション学会雑誌, 35, 1, 83, 84, Dec. 2022
  日本口腔リハビリテーション学会, Japanese
• がん治療に関連した口腔カンジダ症の臨床的検討
  今待 賢治; 秦 浩信; 北川 善政, 日本口腔診断学会雑誌, 35, 1, 98, 98, Feb. 2022
  (一社)日本口腔診断学会, Japanese
• がん治療に関連した口腔カンジダ症の臨床的検討
  今待 賢治; 秦 浩信; 北川 善政, 日本口腔内科学会雑誌, 27, 2, 98, 98, Dec. 2021
  (一社)日本口腔内科学会, Japanese
• がんの周術期口腔機能管理における病院間連携 末梢血幹細胞移植前に緊急の歯周治療を要した多発性骨髄腫の一例
  江戸 美奈子; 今待 賢治; 圖司 陽子; 宮本 亜有美; 諸橋 悠希; 國井 信彦; 秦 浩信, 国立病院総合医学会講演抄録集, 75回, 367, 367, Oct. 2021
  国立病院総合医学会, Japanese
• 口腔癌に対する治療戦略 進行口腔扁平上皮癌に対する治療法の再考
  上田 倫弘; 林 信; 新山 宗; 栗林 和代; 篠原 早紀; 秦 浩信; 今待 賢治, 日本癌治療学会学術集会抄録集, 59回, SY15, 4, Oct. 2021
  (一社)日本癌治療学会, English
• 口腔内カメラを用いた新たな口腔衛生指導法の有効性
  江戸 美奈子; 圖司 陽子; 宮本 亜有美; 諸橋 悠希; 今待 賢治; 國井 信彦; 秦 浩信, 日本歯科衛生学会雑誌, 16, 1, 73, 73, Aug. 2021
  日本歯科衛生学会, Japanese
• 待機時間2時間は充分か 顎骨SPECT定量解析における撮像待機時間の研究
  秦 浩信; 下村 悟史; 今待 賢治; 舩山 恭祐; 浅香 卓哉; 佐藤 淳; 平田 健司; 松坂 方士; 盛 洋一; 南部 敏和; 北川 善政, 核医学, 58, Suppl., S216, S216, 2021
  (一社)日本核医学会, Japanese
• 歯科衛生士が骨吸収抑制薬関連顎骨壊死の予防と管理に関与した2症例
  江戸 美奈子; 圖司 陽子; 宮本 亜有美; 諸橋 悠希; 今待 賢治; 國井 信彦; 秦 浩信, 国立病院総合医学会講演抄録集, 74回, O56, 1, Oct. 2020
  国立病院総合医学会, Japanese
• デンタルインプラント周囲炎による骨吸収抑制薬関連顎骨壊死 顎骨の病的骨折に至った前立腺癌骨転移の1例
  秦 浩信; 今待 賢治; 國井 信彦; 江戸 美奈子; 原林 透; 吉川 和人; 北川 善政, 国立病院総合医学会講演抄録集, 74回, P, 649, Oct. 2020
  国立病院総合医学会, Japanese
• 北海道におけるハイドロゲル創傷被覆・保護材の使用状況に関する実態調査(第1報)
  秦 浩信; 今待 賢治; 江戸 美奈子; 江端 正祐; 原田 祥二; 大聖 康洋; 山本 誠; 岡田 実継, 日本口腔ケア学会雑誌, 14, 3, 94, 94, Sep. 2020
  (一社)日本口腔ケア学会, Japanese
• 舌下型ガマ腫(ranula)に対しOK-432注入療法を行った1例
  秦 浩信; 國井 信彦; 今待 賢治; 江戸 美奈子; 新山 宗; 林 信; 上田 倫弘, 国立病院総合医学会講演抄録集, 73回, O49, 1, Nov. 2019
  国立病院総合医学会, Japanese
• 骨SPECT定量解析の抜歯判断への応用 ARONJ予防に向けた予備調査(第一報)
  秦 浩信; 北尾 友香; 今待 賢治; 浅香 卓哉; 佐藤 淳; 平田 賢治; 志賀 哲; 北川 善政, 核医学, 56, Suppl., S177, S177, Oct. 2019
  (一社)日本核医学会, Japanese
• 骨SPECTシンチグラフィ定量解析ソフトウェアによる骨髄炎の評価
  秦 浩信; 北尾 友香; 浅香 卓哉; 佐藤 淳; 宮腰 昌明; 大賀 則孝; 今待 賢治; 平田 賢治; 志賀 哲; 北川 善政, 核医学, 55, Suppl., S180, S180, Nov. 2018
  (一社)日本核医学会, English
• 骨SPECT定量解析ソフトウェアGI-BONEにより顎骨骨髄炎のモニタリングを行った1例
  秦 浩信; 北尾 友香; 今待 賢治; 江戸 美奈子; 國井 信彦; 上田 倫弘; 林 信; 新山 宗; 関澤 充規; 北川 善政, 国立病院総合医学会講演抄録集, 72回, 960, 960, Nov. 2018
  国立病院総合医学会, Japanese
• 医療安全管理の深化 全身麻酔手術時の口腔内リスク軽減に向けた取り組み(第一報) 義歯装着入室ゼロを目指して
  江戸 美奈子; 今待 賢治; 國井 信彦; 圖司 陽子; 宮本 亜有美; 土屋 健二; 森下 健康; 南 由紀恵; 上村 雅恵; 秦 浩信, 国立病院総合医学会講演抄録集, 72回, 1407, 1407, Nov. 2018
  国立病院総合医学会, Japanese
• Quality of Survivalを考慮した頭頸部癌支持療法 頭頸部がん患者の口腔支持療法と地域連携
  秦 浩信; 吉川 和人; 今待 賢治; 上田 倫弘; 永橋 立望; 西山 典明; 安田 耕一; 本間 明宏; 北川 善政, 頭頸部癌, 44, 2, 115, 115, May 2018
  (一社)日本頭頸部癌学会, Japanese
• 再発口腔癌患者に対してNivolumabを使用した4例
  林 信; 上田 倫弘; 新山 崇; 秦 浩信; 今待 賢治, 頭頸部癌, 44, 2, 212, 212, May 2018
  (一社)日本頭頸部癌学会, Japanese
• 歯科衛生士と他施設コメディカル間の口腔ケア情報共有の実際
  江戸 美奈子; 秦 浩信; 今待 賢治; 圖司 陽子; 金渕 亜有美; 吉川 和人; 國井 信彦; 新山 宗; 林 信; 上田 倫弘, 日本口腔診断学会雑誌, 31, 1, 114, 114, Feb. 2018
  (一社)日本口腔診断学会, Japanese
• 歯科衛生士と他施設コメディカル間の口腔ケア情報共有の実際
  江戸 美奈子; 秦 浩信; 今待 賢治; 圖司 陽子; 金渕 亜有美; 吉川 和人; 國井 信彦; 新山 宗; 林 信; 上田 倫弘, 日本口腔内科学会雑誌, 23, 2, 158, 158, Dec. 2017
  (一社)日本口腔内科学会, Japanese
• オトガイ下膿瘍を来したがん患者のMRONJの2例
  今待 賢治; 秦 浩信; 吉川 和人; 鎌口 真由美; 林 信; 上田 倫弘, 国立病院総合医学会講演抄録集, 71回, 1211, 1211, Nov. 2017
  国立病院総合医学会, Japanese
• がん患者のARONJに対する休薬の意義とリスク関する検討
  秦 浩信; 吉川 和人; 今待 賢治; 鎌口 真由美; 林 信; 上田 倫弘, 日本口腔科学会雑誌, 66, 2, 96, 96, Jul. 2017
  (NPO)日本口腔科学会, Japanese
• 骨髄炎の新たな評価方法としての骨SPECT定量解析ソフトGI-BONEの有用性
  秦 浩信; 浅香 卓哉; 大賀 則孝; 宮腰 昌明; 吉川 和人; 今待 賢治; 黒嶋 雄志; 佐藤 淳; 北川 善政, 日本口腔科学会雑誌, 66, 2, 126, 126, Jul. 2017
  (NPO)日本口腔科学会, Japanese
• 当科における後期高齢者口腔扁平上皮癌手術症例の臨床的検討
  今待 賢治; 坪井 香奈子; 黒嶋 雄志; 吉川 和人; 宮腰 昌明; 佐藤 明; 北川 善政, 頭頸部癌, 43, 2, 212, 212, May 2017
  (一社)日本頭頸部癌学会, Japanese
• 口腔内に初発症状を呈した急性前骨髄球性白血病の1例
  今待 賢治; 山崎 裕; 北川 善政, 日本口腔診断学会雑誌, 30, 1, 107, 107, Feb. 2017
  日本口腔診断学会, Japanese
• 口腔内に初発症状を呈した急性前骨髄球性白血病の1例
  今待 賢治; 山崎 裕; 北川 善政, 日本口腔診断学会雑誌, 30, 1, 107, 107, Feb. 2017
  (一社)日本口腔診断学会, Japanese
• 口腔内に初発症状を呈した急性前骨髄球性白血病の1例
  今待 賢治; 山崎 裕; 北川 善政, 日本口腔内科学会雑誌, 22, 2, 123, 123, Dec. 2016
  (一社)日本口腔内科学会, Japanese
• 角化嚢胞性歯原性腫瘍摘出術後、病的骨折部位に異常骨吸収を認めた1例
  宮腰 昌明; 大賀 則孝; 今待 賢治; 吉川 和人; 佐藤 千晴; 佐藤 明; 北川 善政, 口腔顎顔面外傷, 15, 1-2, 71, 71, Dec. 2016
  日本口腔顎顔面外傷学会, Japanese
• 口腔内に初発症状を呈した急性前骨髄球性白血病の1例
  今待 賢治; 山崎 裕; 北川 善政, 日本口腔内科学会雑誌, 22, 2, 123, 123, Dec. 2016
  (一社)日本口腔内科学会, Japanese
• 当院の第一期がん診療医科歯科前連携トライアルにおけるアンケート調査結果
  江戸 美奈子; 秦 浩信; 加藤 秀則; 菊地 久美子; 吉川 和人; 今待 賢治; 國井 信彦; 鎌口 真由美; 近藤 啓史, 国立病院総合医学会講演抄録集, 70回, P2, 3, Nov. 2016
  国立病院総合医学会, Japanese
• 北海道がんセンターにおけるがん診療医科歯科前連携システム構築の取り組み
  秦 浩信; 加藤 秀則; 菊地 久美子; 江戸 美奈子; 吉川 和人; 國井 信彦; 今待 賢治; 鎌口 真由美; 渡邊 健一; 高橋 將人; 永森 聡; 近藤 啓史, 国立病院総合医学会講演抄録集, 70回, P4, 5, Nov. 2016
  国立病院総合医学会, Japanese
• 舌扁平上皮癌stage II症例における臨床病理学的検討
  今待 賢治; 草深 公秀; 鬼塚 哲郎; 上條 朋之; 飯田 善幸; 百合草 健圭志, 頭頸部癌, 42, 2, 196, 196, May 2016
  (一社)日本頭頸部癌学会, Japanese
• 早期舌扁平上皮癌症例における後発リンパ節転移群の臨床病理学的検討
  今待 賢治; 草深 公秀; 鬼塚 哲郎; 今井 篤志; 上條 朋之; 飯田 善幸; 百合草 健圭志, 頭頸部癌, 41, 2, 213, 213, May 2015
  (一社)日本頭頸部癌学会, Japanese
• 鼻副鼻腔悪性黒色腫に対する陽子線治療後の顎骨壊死に関する臨床的検討
  古川 康平; 今待 賢治; 村山 重行; 百合草 健圭志, 頭頸部癌, 41, 2, 229, 229, May 2015
  (一社)日本頭頸部癌学会, Japanese
• 口腔に発生した偽血管肉腫様癌(Pseudoangiosarcomatous carcinoma:PAC)の2例
  草深 公秀; 上條 朋之; 飯田 善幸; 村井 知佳; 今待 賢治; 今井 篤志; 鬼塚 哲郎, 頭頸部癌, 41, 2, 236, 236, May 2015
  (一社)日本頭頸部癌学会, Japanese
• 発がん関連RNA結合タンパクHuRの分解抑制機構
  東野 史裕; 今待 賢治; 北村 哲也; 柳川 彩[松田]; 進藤 正信, 日本口腔科学会雑誌, 63, 4, 386, 386, Sep. 2014
  (NPO)日本口腔科学会, Japanese
• pp32r1はHuRと結合しクリベージを抑制することで細胞がん化誘導にはたらく
  今待 賢治; 東野 史裕; 北村 哲也; 松田 彩; 北川 善政; 進藤 正信, 日本口腔科学会雑誌, 63, 1, 121, 121, Jan. 2014
  (NPO)日本口腔科学会, Japanese
• 発がん活性を持つpp32r1はHuRと結合しその分解を抑制する
  今待 賢治, 北海道歯学雑誌, 33, 2, 203, 203, Mar. 2013
  北海道歯学会, Japanese
• pp32r1はRNA結合タンパクHuRと結合しその分解を抑制する(pp32r1 binds to RNA binding protein HuR to prevent its cleavage)
  今待 賢治; 北村 哲也; 柳川 彩; 進藤 正信; 東野 史裕, 日本癌学会総会記事, 71回, 442, 442, Aug. 2012
  (一社)日本癌学会, English
• 頭頸部癌患者を支えるチーム医療 大学病院での頭頸部がん治療における口腔ケアの取り組みについて
  秦 浩信; 山崎 裕; 佐藤 淳; 村田 翼; 村井 知佳; 今待 賢治; 本間 明宏; 北川 善政, 頭頸部癌, 37, 2, 181, 181, May 2011
  (一社)日本頭頸部癌学会, Japanese
• 下顎骨内に発生した多形腺腫の1例
  今待 賢治; 山崎 裕; 村井 知佳; 進藤 正信; 北川 善政, 日本口腔外科学会雑誌, 55, Suppl., 134, 134, Sep. 2009
  (公社)日本口腔外科学会, Japanese
• 頭頸部癌治療における口腔ケアの実際 頭頸部進行癌に対する再建手術の合併症減少に口腔ケアは寄与するか
  秦 浩信; 山崎 裕; 佐藤 淳; 村井 知佳; 中村 裕介; 今待 賢治; 北川 善政; 本間 明宏; 瀧 重成; 折舘 伸彦; 福田 諭; 斉藤 亮; 古川 洋志; 山本 有平; 関堂 充, 頭頸部癌, 35, 2, 71, 71, May 2009
  (一社)日本頭頸部癌学会, Japanese

• Post-Extraction Adverse Events In Patients On Bevacizumab: A Single Center Study.
  Kenji Imamachi; Hironobu Hata; Kazuhito Yoshikawa; Yoshimasa Kitagawa
  MASCC/ISOO Annual Meeting, Oral presentation
  24 Jun. 2021 - 26 Jun. 2021

• 口腔構造解析学, 2024年, 博士後期課程, 歯学院
• 口腔構造解析学研究, 2024年, 博士後期課程, 歯学院
• 口腔機能解剖学, 2024年, 博士後期課程, 歯学院
• 口腔機能解剖学研究, 2024年, 博士後期課程, 歯学院
• 口腔生物学と医学, 2024年, 博士後期課程, 歯学院
• 歯の解剖学, 2024年, 学士課程, 歯学部
• 解剖学・口腔解剖学Ⅰ, 2024年, 学士課程, 歯学部
• 解剖学・口腔解剖学Ⅱ, 2024年, 学士課程, 歯学部
• 解剖学・口腔解剖学実習, 2024年, 学士課程, 歯学部
• 健康と社会, 2024年, 学士課程, 全学教育

• 漢方を応用した経管栄養による口腔乾燥の予防法確立を目指して
  科学研究費助成事業
  01 Apr. 2026 - 31 Mar. 2029
  今待 賢治
  日本学術振興会, 基盤研究(C), 北海道大学, 26K12973
• Aiming for inter-facility standardization for quantitative SPECT of the jaw
  Grants-in-Aid for Scientific Research
  01 Apr. 2022 - 31 Mar. 2025
  秦 浩信; 北川 善政; 平田 健司; 三輪 建太; 今待 賢治; 佐藤 淳; 松坂 方士; 浅香 卓哉
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido Cancer Center(Department of Clinical Research), 22K10137
• 血管新生阻害薬使用患者における抜歯の安全性評価と治癒遅延予測バイオマーカーの確立
  科学研究費助成事業
  01 Apr. 2019 - 31 Mar. 2023
  今待 賢治
  本研究の目的は①血管新生阻害薬投与中のがん患者における抜歯の安全性を評価し創傷治癒遅延の頻度やリスク因子を明らかにすること。②休薬の必要性や休薬期間などを検討して血管新生阻害薬投与中の抜歯に関する新たなガイドラインの重要なエビデンスを確立すること。の2点である。単一施設での調査ではBVの継続群と休薬群では抜歯後有害事象について有意差は認めなかった（p=0.35）。リスク因子の検討ではタキサン系抗癌剤の併用で有意にリスクが上昇した（OR(オッズ比):17.50,p=0.018)。また、下顎大臼歯(OR:10.91,p=0.018)や、骨削除などを伴う外科的抜歯(OR:9.14,p=0.002)においても有意にリスクが上昇した。本研究成果については2021年6月にMASCC（Multinational Association of Supportive Care in Cancer）総会で報告した。
  また、抜歯の有無に限らず歯科介入を行ったBV投与患者の調査も進めており、その中でBV単独投与による薬剤関連顎骨壊死（MRONJ）が発生した症例が3例認めた。発生部位は下顎臼後部舌側、上顎大臼歯部口蓋側、口蓋隆起部であった。いずれも抜歯等を契機とせず、early srageで止まることが多く、治療に難渋するケースは少なかった。抜歯窩治癒遅延のメカニズムとも関連が深いと考えられ、今後も調査・研究を進める予定である。尚、MRONJ症例については、第66回日本口腔外科学会（2021年11月Web開催）にて報告した。
  これまでの調査ではBV投与中の抜歯に関して休薬は不要である可能性が高いが、下顎大臼歯や骨削を伴う侵襲の大きな抜歯、タキサン系抗癌剤との併用がある場合には休薬を考慮する必要があると考えられる。どの程度の期間の休薬が最も有効なのかなどについては更なる検討が必要であると考える。
  日本学術振興会, 若手研究, 独立行政法人国立病院機構北海道がんセンター(臨床研究部), 19K19219
• Standardization of SPECT quantitative analysis for osteomyelitis of the jaw and challenges for the development of treatment method of ARONJ
  Grants-in-Aid for Scientific Research
  01 Apr. 2019 - 31 Mar. 2022
  Hata Hironobu
  In this study, quantitative image analysis of bone SPECT was performed before and after medication related osteonecrosis of the jaw (MRONJ)'s anti-inflammatory treatment. As a result, we demonstrated that standardized uptake value(SUV) comparison and monitoring between patients in the same facility is possible. In addition, bone SPECT quantitative analysis proved to be a highly reproducible test method. When 14 new cases of SPECT imaging for dental osteomyelitis that did not use BP were added and compared, the SUV value of the parietal bone was higher than that of BP used cases MRONJ. It was found that dental osteomyelitis was significantly lower (p <0.01), and that there was a correlation between the duration of BP use and the SUV value of the parietal bone.These results were published in two English articles.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido Cancer Center(Department of Clinical Research), 19K10279