Maki Miyajima(Faculty of Health Sciences　Health Sciences　Department of Rehabilitation Science)

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Maki Miyajima

Faculty of Health Sciences　Health Sciences　Department of Rehabilitation Science Lecturer

Researcher basic information

■ Degree

保健科学博士, 北海道大学

■ URL
researchmap URL

https://researchmap.jp/mmiyajima?lang=en

ホームページURL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201801006579613919

■ Various IDs
J-Global ID

201801006579613919

■ Research Keywords and Fields
Research Keyword

細胞老化

慢性炎症

リハビリテーション

認知機能改善療法

自閉スペクトラム症

Research Field

Life Science, Rehabilitation science

Life Science, Psychiatry

■ Educational Organization

Bachelor's degree program, Departments of Health Sciences, School of Medicine

Master's degree program, Graduate School of Health Sciences

Doctoral (PhD) degree program, Graduate School of Health Sciences

Career

■ Career
Career

Oct. 2023 - Present
北海道大学大学院保健科学研究院講師

Mar. 2020 - Present
Sapporo Medical University

Apr. 2018 - Sep. 2023
北海道大学大学院保健科学研究院助教

Apr. 2013 - Mar. 2018
北仁会旭山病院

Committee Memberships

2019 - Present
作業療法の実践と科学, 査読委員

2018 - Present
日本作業療法学会, 演題審査委員

Research activity information

■ Papers

The impact of social and solitary activities on loneliness in older rural male adults: A path analysis study.
Shan Yun; Hiroki Okada; Yuri Matsuzaki; Maki Miyajima; Risa Takashima
Journal of rural health, 42, 1, e70131, Jan. 2026, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: Loneliness is a serious concern among older rural men. This study examined how social and solitary activities are associated with each other and collectively relate to loneliness through path analysis. Two models were hypothesized: (1) solitary activities performance is associated with social activities, thereby relating to loneliness, and (2) social activity participation is associated with solitary activities, which in turn relates to loneliness. METHODS: Data were collected from 510 men aged 65 years and older residing in a rural Japanese town using self-administered questionnaires. The study measured loneliness (Japanese version of the UCLA Loneliness Scale), performance in social and solitary activities (Self-completed Occupational Performance Index), number of social activities (Vivid Social Activities Checklist), and depressive symptoms (Geriatric Depression Scale). Structural equation modeling was conducted; model fit was assessed using absolute, incremental, and parsimony indices. FINDINGS: Model 2 demonstrated acceptable fit (χ2 = 0.923, comparative fit index = 1.000, normed fit index = 1.000, root mean square error of approximation<0.001, Akaike information criterion = 38.009, Expected Cross-Validation Index = 0.074, and Hoelter = 208.044). Social activities were associated with solitary activities, which were in turn related to loneliness. Solitary activities were indirectly associated with loneliness through depression. CONCLUSIONS: This study demonstrates that higher performance in social activities may support healthier, more autonomous solitary engagement as a component of the social-solitary balance that shapes loneliness among older rural men. Locally grounded opportunities that enable meaningful social connection in addition to enhancing rural work rhythms and self-directed solitary routines may help reduce loneliness and support well-being in later life.

Orchestration of Skin Pathology in Cutaneous Lupus Erythematosus by HLA Class I Down-Regulated Senescent Epidermal Basal Cells.
Sena Yamamoto; Yuki Saito; Tsukasa Sato; Seina Nakano; Dain Kasseki; Ayaka Nagao; Norihiro Miura; Kentaro Nagaoka; Arisa Kita; Maki Miyajima; Shogo Ijima; Koji Taniguchi; Atsushi Niida; Takako S Chikenji
Arthritis & rheumatology (Hoboken, N.J.), 77, 12, 1713, 1725, Dec. 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVE: To investigate the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE). METHODS: Cellular senescence profiling utilized datasets from the NCBI Gene Expression Omnibus database and Accelerating Medicines Partnership® (AMP®) Phase 1-Metro. Gene array data from GSE184989 (CLE: n = 68, control: n = 4), single-cell RNA sequencing data from GSE186476 (CLE: n = 7, control: n = 14), and AMP® Phase 1-Metro (SLE: n = 17) were utilized. In vitro experiments further examined the expression of p21WAF1/CIP1, type I interferon (IFN), human leukocyte antigen class I (HLA-I), and epidermal growth factor receptor (EGFR) signalling. Pharmacological clearance of senescent cells was performed using the senolytic drug fisetin in the SLE mouse model. RESULTS: p21WAF1/CIP1-high senescent epidermal basal cells in patients with CLE exhibit high type I IFN expression. These cells enhance IFN signalling in surrounding normal epidermal basal cells, leading to increased HLA-I expression. In contrast, senescent epidermal cells upregulate EGFR signalling, which downregulates HLA-I expression, allowing them to evade immune surveillance. This heterogeneity of HLA-I expression promotes CD8-positive T-mediated toxicity against normal epidermal basal cells, resulting in their apoptosis. Pharmacological clearance of senescent epidermal basal cells improved SLE-like skin lesions. CONCLUSION: Senescent cells create a microenvironment that directs cytotoxic T-cell-mediated responses against normal epidermis in CLE, contributing to disease pathology. Targeting senescent cells and their signalling pathways may offer novel therapeutic strategies for CLE and SLE skin lesions.

Loneliness and social participation among older Japanese adults: The influence of gender on social participation.
Yuri Matsuzaki; Risa Takashima; Hiroki Okada; Maki Miyajima
PloS one, 20, 11, e0334762, 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, Previous studies have demonstrated that social participation can alleviate loneliness; however, the specific types and characteristics of social participation that contribute to loneliness prevention remain unclear, particularly considering gender differences. In this study, we examined the gender-related influence of the types and characteristics of social participation on loneliness among older adults aged ≥65 years. A total of 381 participants (175 men and 206 women) from a regional city in Hokkaido, Japan, completed questionnaires assessing loneliness, social participation, life-space mobility, self-evaluation of abilities, and depression. Hierarchical multiple regression analysis revealed that loneliness among men was significantly associated with participation in neighborhood association activities, group exercise, and depression, suggesting that maintaining social roles and responsibilities through these activities is essential for reducing loneliness. In contrast, for women, no specific type of social participation had a significant effect on loneliness. However, correlation analysis indicated that women's loneliness was related to a broader range of social participation compared to that of men. These findings suggest that, for women, the extent of participation across various types of social participation is more important than engaging in specific types. Providing accessible opportunities for diverse forms of participation may be particularly effective in reducing loneliness among women. This study highlights the importance of developing gender-specific interventions to prevent loneliness. Tailored support strategies that consider the differing social roles, patterns of participation, and needs of men and women are necessary to effectively address loneliness among older adults.

Characteristics of Older Adults Experiencing High Loneliness Despite Active Social Participation: A Cross-Sectional Study.
Yuri Matsuzaki; Hiroki Okada; Maki Miyajima; Rika Hirayama; Risa Takashima
INQUIRY: The Journal of Health Care Organization, Provision, and Financing, 62, 469580251360650, 469580251360650, 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, Although social activity reduces loneliness levels, this relationship is not always consistent. Some older adults experience high loneliness despite active social participation. We aimed to clarify the characteristics of these individuals by focusing on their preference for solitude and satisfaction with and performance in valuable social and solitary activities. This cross-sectional survey included 3205 individuals aged ≥65 years and assessed loneliness, participation in social activities, preference for solitude, performance of valuable social and solitary activities, and depression. Participants were categorized into 3 groups based on the relationship between loneliness and social activity participation: higher social activity with a tendency toward loneliness, lower social activity without a tendency toward loneliness, and a correlated group. A one-way analysis of variance was conducted to clarify each group's characteristics. Structural equation modeling was used to explore the structure underlying the discrepancy between loneliness and social activity. Older adults experiencing high loneliness despite active social engagement preferred solitude, had low performance of valuable social and solitary activities, and reported high depression. In the high loneliness despite social activity group, a higher preference for solitude was associated with a decreased performance of social activities valuable to the individual, leading to reduced performance of solitary activities valuable to the individual. These effects contributed to increased depression, further exacerbating the discrepancy between loneliness and social activity. Some older adults may experience little to no benefit from increasing social activities. Social activities that consider older adults' solitude values could be more effective in addressing loneliness.

Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus.
Shogo Ijima; Yuki Saito; Sena Yamamoto; Kentaro Nagaoka; Taiki Iwamoto; Arisa Kita; Maki Miyajima; Tsukasa Sato; Akihiro Miyazaki; Takako S Chikenji
Immunity & ageing : I & A, 20, 1, 72, 72, 05 Dec. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remains elusive. Consequently, therapeutic interventions for oral lichen planus are limited to symptomatic management. This study provides evidence of the accumulation of senescent mesenchymal cells, CD8 + T cells, and natural killer cells in patients with oral lichen planus. We profiled the patients' tissues using the National Center for Biotechnology Information Gene Expression Omnibus database and found that senescence-related genes were upregulated in these tissues by gene set enrichment analysis. Immunohistochemical analysis showed increased senescent mesenchymal cells in the subepithelial layer of patients with oral lichen planus. Single-cell RNA-seq data retrieved from the Gene Expression Omnibus database of patients with oral lichen planus revealed that mesenchymal cells were marked by the upregulation of senescence-related genes. Cell-cell communication analysis using CellChat showed that senescent mesenchymal cells significantly influenced CD8 + T cells and natural killer cells via CXCL12-CXCR4 signaling, which is known to activate and recruit CD8 + T cells and NK cells. Finally, in vitro assays demonstrated that the secretion of senescence-associated factors from mesenchymal cells stimulated the activation of T cells and natural killer cells and promoted epithelial cell senescence and cytotoxicity. These findings suggest that the accumulation of mesenchymal cells with senescence-associated secretory phenotype may be a key driver of oral lichen planus pathogenesis.

孤立と孤独感の乖離が生じている高齢者の臨床的特徴
松崎由莉; 高島理沙; 宮島真貴; 岡田宏基
日本作業療法学会抄録集, 57回, OJ, 2, (一社)日本作業療法士協会, Nov. 2023, [Peer-reviewed]
Japanese

医療従事者における車椅子観察の視点～下肢に着目したアンケート調査～
浮田徳樹,相原彩香,宮島真貴
車椅子シーティング研究, 8, 1, 2, 10, Nov. 2023, [Peer-reviewed]
Scientific journal

The Effects of Cognitive Rehabilitation Targeting Frontal Lobe Executive Function in Mild Cognitive Impairment
Yuri Matsuzaki; Hidetoshi Omiya; Takayuki Hisakura; Hiroki Tanii; Maki Miyajima
Asian Journal of Occupational Therapy, 19, 1, 205, 212, Japanese Association of Occupational Therapists, 2023, [Peer-reviewed], [Corresponding author]
Scientific journal

Risk level-specific hazardous drinking factors of alcohol use disorders in Japanese university students
Miyajima Maki; Miyata Tomoki; Murakami Yui; Yotsumoto Kayano; Ukita Atsuki; MorimotoTakafumi; Kobayashi Masayoshi; Tanaka Hiroyuki; Yamada Sumie; Matsusaki Yuri; Inoue Takao
Journal of Substance Use, Oct. 2022, [Peer-reviewed], [Lead author]
Scientific journal

A Pilot Study of Illness Management and Recovery in Patients Acutely Admitted to a Psychiatric Ward
Maki Miyajima; Yukie Hatakeyama; Kazumasa Ichiki; Yuri Matsuzaki; Hazuki Niyama; Hidetoshi Omiya
Journal of Psychosocial Rehabilitation and Mental Health, Springer Science and Business Media LLC, 28 Jul. 2022, [Peer-reviewed], [Lead author]
Scientific journal

Intrathecal Injection of Mesenchymal Stromal Cell Cultured on 3D Fiber Ameliorates Multiple Organ Damage in Murine Lupus.
Yuki Saito; Maki Miyajima; Sena Yamamoto; Norihiro Miura; Tsukasa Sato; Arisa Kita; Shogo Ijima; Mineko Fujimiya; Takako S Chikenji
Stem cells translational medicine, 11, 6, 644, 658, Oxford University Press (OUP), 22 Jun. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Abstract

Up to 60% of patients with systemic lupus erythematosus (SLE) experience autonomic symptom. Sympathetic nervous system damage can cause dysfunction of the bone marrow that activates inflammatory cells, potentially causing multiple organ damage. We hypothesized that sympathetic nervous system damage would induce bone marrow dysfunction with multiple organ damage in SLE, and that multiple organ damage could be improved by therapy targeting the nervous system. Here, we showed that damage to autonomic nerves and Schwann cells occurred in the bone marrow and central nervous system of SLE model mice. A neurotoxic drug increased mortality and induced severe neuropathy and multiple organ damage, while a neuroprotective drug prevented multiple organ damage. The administration of bone marrow-derived mesenchymal stromal cells (BMSCs) cultured on a 3-dimensional fiber scaffold improved bone marrow neuropathy, skin lesions, kidney function, and mortality. Our results reveal that bone marrow neuropathy influence multiple organ damage associated with SLE, and improvement of bone marrow neuropathy by intrathecal injection of BMSC may be a target for SLE multiple-organ damage.

Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing.
Arisa Kita; Yuki Saito; Norihiro Miura; Maki Miyajima; Sena Yamamoto; Tsukasa Sato; Takatoshi Yotsuyanagi; Mineko Fujimiya; Takako S Chikenji
Communications biology, 5, 1, 310, 310, Springer Science and Business Media LLC, 05 Apr. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Abstract

Pathologic diabetic wound healing is caused by sequential and progressive deterioration of hemostasis, inflammation, proliferation, and resolution/remodeling. Cellular senescence promotes wound healing; however, diabetic wounds exhibit low levels of senescent factors and accumulate senescent cells, which impair the healing process. Here we show that the number of p15^INK4B + PDGFRα + senescent mesenchymal cells in adipose tissue increases transiently during early phases of wound healing in both non-diabetic mice and humans. Transplantation of adipose tissue from diabetic mice into non-diabetic mice results in impaired wound healing and an altered cellular senescence–associated secretory phenotype (SASP), suggesting that insufficient induction of adipose tissue senescence after injury is a pathological mechanism of diabetic wound healing. These results provide insight into how regulation of senescence in adipose tissue contributes to wound healing and could constitute a basis for developing therapeutic treatment for wound healing impairment in diabetes.

Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis.
Shogo Ijima; Yuki Saito; Kentaro Nagaoka; Sena Yamamoto; Tsukasa Sato; Norihiro Miura; Taiki Iwamoto; Maki Miyajima; Takako S Chikenji
Frontiers in immunology, 13, 960601, 960601, Oct. 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by the involvement of multiple organs. Lupus nephritis (LN) is a major risk factor for overall morbidity and mortality in SLE patients. Hence, designing effective drugs is pivotal for treating individuals with LN. Fisetin plays a senolytic role by specifically eliminating senescent cells, inhibiting cell proliferation, and exerting anti-inflammatory, anti-oxidant, and anti-tumorigenic effects. However, limited research has been conducted on the utility and therapeutic mechanisms of fisetin in chronic inflammation. Similarly, whether the effects of fisetin depend on cell type remains unclear. In this study, we found that LN-prone MRL/lpr mice demonstrated accumulation of Ki-67-positive myofibroblasts and p15INK4B-positive senescent tubular epithelial cells (TECs) that highly expressed transforming growth factor β (TGF-β). TGF-β stimulation induced senescence of NRK-52E renal TECs and proliferation of NRK-49F renal fibroblasts, suggesting that TGF-β promotes senescence and proliferation in a cell type-dependent manner, which is inhibited by fisetin treatment in vitro. Furthermore, fisetin treatment in vivo reduced the number of senescent TECs and myofibroblasts, which attenuated kidney fibrosis, reduced senescence-associated secretory phenotype (SASP) expression, and increased TEC proliferation. These data suggest that the effects of fisetin vary depending on the cell type and may have therapeutic effects in complex and diverse LN pathologies.

Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior.
Yuki Saito; Maki Miyajima; Sena Yamamoto; Tsukasa Sato; Norihiro Miura; Mineko Fujimiya; Takako S Chikenji
Frontiers in immunology, 12, 692321, 692321, 03 Nov. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Neuropsychiatric manifestations targeting the central, peripheral, and autonomic nervous system are common in systemic lupus erythematosus (SLE); collectively, these symptoms are termed neuropsychiatric SLE (NPSLE). Among a wide variety of neuropsychiatric symptoms, depression is observed in about 24-39% of SLE patients. Several cytokines and chemokines have been identified as biomarkers or therapeutic targets of NPSLE; in particular, the levels of type 1 interferons, TNFs, and IL-6 are elevated in SLE patient's cerebrospinal fluid (CSF), and these factors contribute to the pathology of depression. Here, we show that senescent neural cells accumulate in the hippocampal cornu ammonis 3 (CA3) region in MRL/lpr SLE model mice with depressive behavior. Furthermore, oral administration of fisetin, a senolytic drug, reduced the number of senescent neural cells and reduced depressive behavior in the MRL/lpr mice. In addition, transcription of several senescence and senescence-associated secretory phenotype (SASP) factors in the hippocampal region also decreased after fisetin treatment in the MRL/lpr mice. These results indicate that the accumulation of senescent neural cells in the hippocampus plays a role in NPSLE pathogenesis, and therapies targeting senescent cells may represent a candidate approach to treat NPSLE.

前頭葉/実行機能プログラム(FEP)を用いて認知機能の改善がみられた軽度認知障害(MCI)の事例
松崎由莉; 宮島真貴; 大宮秀淑
日本作業療法学会抄録集, 53回, PJ, 1F05, (一社)日本作業療法士協会, Sep. 2019, [Peer-reviewed], [Corresponding author]
Japanese

前頭葉/実行機能プログラム（FEP)を用いて認知機能の改善がみられたMCIの一例
松㟢由莉; 宮島真貴; 大宮秀淑
日本認知症予防学会誌, 9, 1, 17, 21, (一社)日本認知症予防学会, Sep. 2019, [Peer-reviewed], [Corresponding author]
Japanese, Scientific journal

The effect of Cognitive Remediation Therapy (CRT) on mild cognitive impairment (MCI)-Case report by Frontal/Executive Program (FEP)-
大宮秀淑; 松㟢由莉; 宮島真貴
札幌学院大学心理学紀要第2巻第１号, 2, 1, 1, 12, 札幌学院大学総合研究所 = Research Institute of Sapporo Gakuin University, 2019, [Peer-reviewed], [Last author]
Japanese, Research institution, The purpose of this study is to examine whether or not an intervention using Frontal / Executive Program （FEP） is effective to improve cognitive functions of people with MCI. Subject was a woman in her 80s who was living alone at the time of the intervention. With regard to her cognitive functions, she was aware of problems with memory, such as being not good at remembering. Total of 22 sessions of FEP were performed; two sessions a week, one on one, each session lasting about an hour. She was assessed to have MCI using MoCA-J. To obtain an objective evaluation before and after the intervention, the Brief Assessment of Cognition in Schizophrenia- Japanese version （BACS-J）, Wisconsin Card Sorting Test （WCST） and Continuous Performance Test （CPT） were performed. As a result, the subject's verbal fluency and digit sequencing performances before the intervention were notably low in BACS-J, but after the intervention, composite score, verbal memory and the Tower of London showed significant improvement. It was shown that FEP improves the results of cognitive function tests, such as reduction of errors in WCST and CPT, suggesting the applicability of FEP to people with MCI. Compared with other mental illnesses, the result of this study was characteristic because the subject's verbal fluency did not show enough improvement. In the future, it will be necessary to conduct further studies with more number of cases and to examine the specificity of MCI's cognitive functions.Article

Therapeutic responses to a frontal/executive programme in autism spectrum disorder: Comparison with schizophrenia.
Maki Miyajima; Hidetoshi Omiya; Kiyoko Yamashita; Kenji Yambe; Mie Matsui; Kenzo Denda
Hong Kong journal of occupational therapy : HKJOT, 31, 2, 69, 75, Dec. 2018, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

認知機能改善療法の紹介二疾患を対象にした前頭葉/実行機能プログラムの有効性の検討
宮島真貴; 大宮秀淑; 山下聖子; 山家研司; 傳田健三
日本作業療法学会抄録集, 51回, OH, 3, (一社)日本作業療法士協会, Sep. 2017, [Peer-reviewed], [Lead author]
Japanese

前頭葉・実行機能プログラム(Frontal/Executive Program;FEP)日本語版の紹介
大宮秀淑; 傳田健三; 山家研司; 松本出; 宮島真貴; 松井三枝
精神医学, 59, 3, 275, 281, (株)医学書院, Mar. 2017, [Peer-reviewed]
Japanese

自閉スペクトラム症に対する認知機能改善療法の効果研究 Frontal/Executive Program(FEP)の有効性
宮島真貴; 大宮秀淑; 山下聖子; 山家研司; 傳田健三
北海道児童青年精神保健学会会誌, 30, 30, 30, 北海道児童青年精神保健学会事務局, Nov. 2016, [Peer-reviewed], [Lead author]
Japanese

Pilot study of the effects of cognitive remediation therapy using the frontal/executive program for treating chronic schizophrenia
Hidetoshi Omiya; Kiyoko Yamashita; Tomoki Miyata; Yukie Hatakeyama; Maki Miyajima; Kenji Yambe; Izuru Matsumoto; Mie Matsui; Atsuhito Toyomaki; Kenzo Denda
Open Psychology Journal, 9, 121, 128, Bentham Science Publishers B.V., 01 Oct. 2016, [Peer-reviewed]
English, Scientific journal

The effects of cognitive remediation therapy using the frontal/executive program for autism spectrum disorder.
Maki Miyajima; Hidetoshi Omiya; Kiyoko Yamashita; Tomoki Miyata; Kenji Yambe; Mie Matsui; Kenzo Denda
International journal of psychiatry in medicine, 51, 3, 223, 35, Apr. 2016, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

統合失調と自閉スペクトラム症における認知機能障害の比較
宮島真貴; 大宮秀淑; 山下聖子; 山家研司; 傳田健三
最新精神医学, 21, 2, 145, 149, (株)世論時報社, Mar. 2016, [Peer-reviewed], [Lead author]
Japanese

自閉スペクトラム症に対する前頭葉/実行機能プログラム(FEP)を用いた認知機能改善療法の効果研究
宮島真貴; 大宮秀淑; 山家研司; 松井三枝; 傳田健三
作業療法, 35, 1, 22, 31, (一社)日本作業療法士協会, Feb. 2016, [Peer-reviewed], [Lead author]
Japanese

前頭葉/実行機能プログラムが有効であった成人期自閉スペクトラム症の1例
宮島真貴; 山下聖子; 松井三枝; 山家研司; 傳田健三
日本作業療法学会抄録集, 20, 2, 169, 175, (一社)日本作業療法士協会, Jun. 2015, [Peer-reviewed]
English

東日本大震災後の高校生における心理状態の変化心理的支援による1年後の変化から
井上貴雄; 船越俊一; 大宮秀淑; 宮島真貴; 傳田健三
こころの健康, 30, 1, 73, 73, 日本精神衛生学会, Jun. 2015
Japanese

統合失調症と広汎性発達障害の認知機能の比較
宮島真貴; 大宮秀淑; 宮田友樹; 山下聖子; 山家研司; 傳田健三
こころの健康, 30, 1, 72, 72, 日本精神衛生学会, Jun. 2015, [Peer-reviewed], [Lead author]
Japanese

前頭葉/実行機能プログラムが有効であった成人期自閉スペクトラム症の1例
宮島真貴; 大宮秀淑; 山下聖子; 松井三枝; 山家研司; 傳田健三
最新精神医学, 20, 2, 169, 175, (株)世論時報社, Mar. 2015, [Peer-reviewed], [Lead author]
Japanese

自然災害の諸要因が高校生の心理状態に及ぼす影響の検討東日本大震災から1年4ヵ月後の高校生実態調査
船越俊一; 大野高志; 小高晃; 奥山純子; 本多奈美; 井上貴雄; 佐藤祐基; 宮島真貴; 富田博秋; 傳田健三; 松岡洋夫
精神神経学雑誌, 116, 7, 541, 554, (公社)日本精神神経学会, Jul. 2014
Japanese

[Factors associated with the psychological impact of the Great East Japan earthquake on high school students 1 year and 4 months after the disaster].
Shunichi Funakoshi; Takashi Ohno; Akira Kodaka; Junko Okuyama; Nami Honda; Takao Inoue; Yuki Sato; Maki Miyajima; Hiroaki Tomita; Kenzou Denda; Hiroo Matsuoka
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 116, 7, 541, 54, 2014, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, The purpose of this study was to investigate factors associated with the psychological impact of the Great East Japan Earthquake on high school students 1 year and 4 months after the disaster, and clarify support needs of the students. In the outreach program for students of three high schools in coastal areas of southern Miyagi Prefecture, Japan, 1,973 students were surveyed after obtaining informed consent for participation. Questionnaires included: the Quick Inventory of Depressive Symptomatology (QIDS-J), Self-rating Anxiety Scale (SAS), Impact of Event Scale-revised (IES-R), and Connor-Davidson Resilience Scale (CD-RISC10). All scores were compared using SPSS 20.0 J between school grades, locations of the schools, and extent of damage due to the Great East Japan Earthquake. Our analysis showed a significant positive correlation between school grades and the level of anxiety. PTSR scores, but not anxiety nor depressive scores, of students whose lives have suffered extensive damage were significantly higher than those of students who have not. Students of high schools which have suffered extensive damage and use temporary buildings showed significantly higher levels of depression and anxiety, and significantly lower resilience, compared to students of high schools which were not damaged. Although previous findings demonstrated that younger children have a higher risk of being influenced by disasters, symptoms related to PTSR and depression were found frequently in the high school students as well. Among the high school students, our analysis showed a positive correlation between the level of anxiety and school grades, probably because the disaster has affected an influential and pivotal point in their lives.

小・中・高校生における抑うつ症状、躁症状および自閉傾向
井上貴雄; 佐藤祐基; 宮島真貴; 傳田健三
児童青年精神医学とその近接領域, 54, 5, 571, 587, (一社)日本児童青年精神医学会, Nov. 2013
Japanese

認知リハビリテーションをきっかけに福祉的就労につながった一症例 NEARによる実践
加藤ちえ; 井上貴雄; 宮島真貴; 豊巻敦人; 橋本直樹
日本作業療法学会抄録集, 47回, O199, O199, (一社)日本作業療法士協会, Jun. 2013
Japanese

統合失調症患者に対する認知矯正療法の効果神経認知機能とThe Schizophrenia Quality of Life Scale日本語版(JSQLS)の変化から
井上貴雄; 加藤ちえ; 宮島真貴; 豊巻敦人; 橋本直樹
日本作業療法学会抄録集, 47回, O202, O202, (一社)日本作業療法士協会, Jun. 2013
Japanese

Discrepancy of neural response between exogenous and endogenous task switching: an event-related potentials study.
Maki Miyajima; Atsuhito Toyomaki; Naoki Hashimoto; Ichiro Kusumi; Harumitsu Murohashi; Tsukasa Koyama
Neuroreport, 23, 11, 642, 6, 01 Aug. 2012, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

小・中・高校生の自閉傾向に関する実態調査自閉症スペクトラム指数日本語版(AQ-J)を用いて
宮島真貴; 井上貴雄; 佐藤祐基; 久住一郎; 傳田健三
最新精神医学, 17, 4, 364, 370, (株)世論時報社, Jul. 2012
Japanese

Comparison of neural responses between exogenous and endogenous rule shifting in cued switching task; an ERPs study.
Maki Miyajima; Atuhito Toyomaki; Ichiro Kusumi; Tsukasa Koyama
Proceedings of the 34th Annual Meeting of the Cognitive Science Society, CogSci 2012, Sapporo, Japan, August 1-4, 2012, cognitivesciencesociety.org, 2012, [Peer-reviewed]

気分障害における作業記憶課題遂行時の事象関連電位・事象関連同期の異常
豊巻敦人; 清水祐輔; 橋本直樹; 宮島真貴; 久住一郎; 小山司
臨床神経生理学, 39, 5, 486, 486, (一社)日本臨床神経生理学会, Oct. 2011
Japanese

【広汎性発達障害とcomorbidity】広汎性発達障害と気分障害
傳田健三; 佐藤祐基; 井上貴雄; 宮島真貴
児童青年精神医学とその近接領域, 52, 2, 143, 150, (一社)日本児童青年精神医学会, Apr. 2011
Japanese

■ Other Activities and Achievements

The Effects of Cognitive Rehabilitation Targeting Frontal Lobe Executive Function in Mild Cognitive Impairment
Yuri Matsuzaki; Hidetoshi Omiya; Maki Miyajima, The Journal of Neuropsychiatry and Clinical Neurosciences, 33, 3, 233, 257, Jul. 2021
American Psychiatric Association Publishing

前頭葉・実行機能プログラム(Frontal/Executive Program;FEP)日本語版の紹介
大宮秀淑; 傳田健三; 山家研司; 松本出; 宮島真貴; 松井三枝, 精神医学, 59, 3, 275, 281, Mar. 2017
(株)医学書院, Japanese

統合失調症患者に対する認知リハビリテーション(ブレインステーション)についての報告北海道大学病院精神科神経科の取り組み
井上貴雄; 橋本直樹; 豊巻敦人; 加藤ちえ; 岸展江; 國田幸治; 中谷紫乃; 川島るい; 佐藤昭宏; 成田学; 松尾萌; 宮島真貴; 清水祐輔; 久住一郎, 精神神経学雑誌, 115, 1, 101, 101, Jan. 2013
(公社)日本精神神経学会, Japanese

■ Books and other publications

最新作業療法学講座精神障害作業療法学
早坂友成
医歯薬出版, Feb. 2025, [Joint work]

精神科リハビリテーション評価法ハンドブック
早坂友成; 編著; 岩根達郎; 編著; 森元隆文
中外医学社, Apr. 2023, 9784498229464, [Joint work]

精神科実臨床における認知機能リハビリテーションの実践
久住, 一郎
中外医学社, Apr. 2023, 9784498229426, vi, 185p, Japanese, [Joint work]

■ Lectures, oral presentations, etc.

運動による間葉系前駆細胞の老化関連遺伝シグネチャーは糖尿病骨格筋で減弱する
葛石大入; 齋藤悠城; 宮島真貴; 佐藤吏紗; 山本瀬菜; 千見寺貴子
第46回日本炎症・再生医学会, Jul. 2025

うつ病患者およびモデルマウスにおける細胞老化関連遺伝子発現の変化
長尾彩花; 齋藤悠城; 佐藤吏紗; 山本瀬菜; 葛石大入; 宮島真貴; 千見寺貴子
第46回日本炎症・再生医学会, Jul. 2025

関節リウマチにおける老化細胞の同定と老化細胞除去による滑膜炎の抑制
葛石大入; 松本陽太; 宮島真貴; 佐藤吏紗; 山本瀬菜; 齋藤悠城; 千見寺貴子
第46回日本炎症・再生医学会, Jul. 2025

自閉スペクトラム症モデルマウスにおける細胞老化とシナプス刈り込み異常
宮島真貴; 齋藤悠城; 佐藤吏紗; 山本瀬奈; 外丸詩野; 石津明洋; 千見寺貴子
第１１回日本小児診療多職種学会, 08 Mar. 2025, Oral presentation
08 Mar. 2025 - 09 Mar. 2025

老化細胞の免疫回避機構が関わる皮膚エリテマトーデス病態
山本瀬菜; 齋藤悠城; 中野世那; 佐藤吏紗; 三浦倫寛; 長岡賢太郎; 北愛里紗; 宮島真貴; 井嶋翔吾; 谷口浩二; 新井田厚司; 千見寺貴子
日本薬学会第145年会, Mar. 2025

Preference for Solitude and Satisfaction with Occupation in Older Adults with Discrepancies Between Loneliness and Social Participation Levels
Yuri Matsuzaki; Maki Miyajima; Hiroki Okada; Rika Hirayama; Risa Takashima
The 8th Asia Pacific Occupational Therapy Congress 2024, 08 Nov. 2024, English
06 Nov. 2024 - 09 Nov. 2024

A Study on the Perceptions of Occupational Therapists in Japanese School Education and Interventions in Educational Settings
Riko Mioka; Karen Kida; Reika Takase; Maki Miyajima
The 8th Asia Pacific Occupational Therapy Congress 2024, 06 Nov. 2024, English
06 Nov. 2024 - 09 Nov. 2024

老化細胞の免疫回避機構に着眼したエリテマトーデスの皮膚病態の解明
山本瀬菜; 齋藤悠城; 中野世那; 佐藤吏紗; 三浦倫寛; 長岡賢太郎; 北愛里紗; 宮島真貴; 井嶋翔吾; 谷口浩二; 新井田厚司; 千見寺貴子
第97回日本生化学会大会, Nov. 2024

Senescent neural progenitor cells increased neurite outgrowth in mouse model of Maki Miyajima1 , Miyu Yokouchi1 , autism spectrum disorders
Maki Miyajima; Miyu Yokouchi; Yuki Saito; Tsukasa Sato; Sena Yamamoto、Utano Tomaru; Akihiro Ishizu; Takako S Chikenji
Cytokines 2024 & KAI 2024, Oct. 2024, English
20 Oct. 2024 - 23 Oct. 2024

Cellular senescence in the hippocampus regulates resilience to chronic stress by secreting neurogenic/protective factors
Tsukasa Sato; Yuki Saito; Sena Yamamoto; Norihiro Miura; Maki Miyajima; Takako S. Chikenji
Cytokines 2024＆ KAI 2024, Oct. 2024, English
20 Oct. 2024 - 23 Oct. 2024

HLA class I-downregulated senescent epidermal basal cells orchestrate skin pathology in systemic lupus erythematosus
Sena Yamamoto,Yuki Saito; Seina Nakano,Tsukasa Sato,Norihiro Miura,Kentaro Nagaoka,Arisa Kita; Maki Miyajima,Shogo Ijima,Koji Taniguchi,Atsushi Niida,Takako S. Chikenji
Cytokines 2024＆ KAI 2024, Oct. 2024, English, Oral presentation
20 Oct. 2024 - 23 Oct. 2024

細胞老化随伴分泌現象は全身性エリテマトーデスにおける表皮細胞の免疫原性を高める
山本瀬菜; 齋藤悠城; 井嶋翔吾; 北愛里紗; 三浦倫寛; 佐藤吏紗; 宮島真貴; 千見寺貴子
第45回日本炎症・再生医学会, Jul. 2024

Exercise-induced senescence-like gene signature in fibro/adipogenic progenitors is impaired in diabetes muscle
Y Saito; N Miura; S Yamamoto; T Sato; K Nagaoka; T Iwamoto; M Miyajima; A Kita; T. S; Chikenji
Cell Bio 23, Dec. 2023, Poster presentation
02 Dec. 2023 - 06 Dec. 2023

Cellular senescence in epidermal stem cells as a potential driver of lupus erythematosus skin lesions
S Yamamoto; Y Saito; T Sato; N Miura; K; Nagaoka,T; Iwamoto; M Miyajima; A Kita,T; S; Chikenji
Cell Bio 23, Dec. 2023, Poster presentation

Involvement of cellular senescence in the pathogenesis of lupus nephritis in mice
K Nagaoka; Y Saito; S Ijima; S; Yamamoto,T Sato; N Miura,T Iwamoto; M; Miyajima,T.S; Chikenji
Cell bio 23, Dec. 2023, Poster presentation

孤立と孤独感の乖離が生じている高齢者の臨床的特徴
松㟢由莉; 髙島理沙; 宮島真貴; 岡田宏基
第57回日本作業療法学会, 11 Nov. 2023

Social Activities Impacting Loneliness among Older Adults in Japan
Yuri Matsuzaki; Risa Takashima; Hiroki Okada; Maki Miyajima
6th FHS International Conference, 20 Oct. 2023

個別の前頭葉・実行機能プログラムにより認知機能が改善した医療観察法入院中の統合失調症の一例
國田幸治; 小野智矢; 大塚敬治; 高信径介; 宮島真貴; 賀古勇輝
第19回日本司法精神医学会大会, 09 Sep. 2023

自閉スペクトラム症モデルマウスにおける神経前駆細胞の細胞老化
宮島真貴; 齋藤悠城; 佐藤吏紗; 山本瀬菜; 三浦倫寛; 千見寺貴子
第44回日本炎症再生医学会, 12 Jul. 2023, Poster presentation

全身性エリテマトーデス皮膚炎における老化細胞の役割とシングルセル解析による病態解明
山本瀬菜; 齋藤悠城; 井嶋翔吾; 北愛里紗; 三浦倫寛; 佐藤吏紗; 宮島真貴; 千見寺貴子
第44回日本炎症再生医学会, 12 Jul. 2023, Poster presentation

滑膜線維芽細胞の細胞老化は関節リウマチにおける炎症性組織プライミング誘導に関与する
齋藤悠城; 岩本大輝; 山本瀬菜; 宮島真貴; 村橋靖崇; 寺本篤史; 射場浩介; 山下敏彦; 千見寺貴子
第44回日本炎症再生医学会, 12 Jul. 2023, Poster presentation

老化細胞除去薬フィセチンが尿細管細胞の細胞老化と腎再生に与える影響
長岡賢太郎; 齋藤悠城; 井嶋翔吾; 山本瀬菜; 佐藤吏紗; 三浦倫寛; 岩本大輝; 宮島真貴; 千見寺貴子
第22回日本再生医療学会, 23 Mar. 2023, Poster presentation

全身性エリテマトーデスの皮膚病態と再生に関わる老化表皮幹細胞
山本瀬菜; 齋藤悠城; 井嶋翔吾; 北愛里紗; 三浦倫寛; 佐藤吏紗; 宮島真貴; 千見寺貴子
第22回日本再生医療学会, 23 Mar. 2023, Oral presentation

海馬における細胞老化は神経新生を促進して慢性ストレス誘発性うつ様症状に抵抗する
佐藤吏紗; 齋藤悠城; 山本瀬菜; 三浦倫寛; 岩本大輝; 長岡賢太郎; 宮島真貴; 千見寺貴子
第22回日本再生医療学会, 23 Mar. 2023, Oral presentation

A PILOT STUDY OF ILLNESS MANAGEMENT AND RECOVERY IN PATIENTS ACUTELY ADMITTED TO A PSYCHIATRIC WARD
Yuri Matsusaki; Hidetoshi Omoiya; Yukie Hatakeyama; Kazumasa Ichiki; Hazuki Niyama; Maki Miyajima
The 22nd WPA World Congress of Psychiatry, 03 Aug. 2022, Poster presentation
03 Aug. 2022 - 06 Aug. 2022

The effects of cognitive rehabilitation targeting frontal lobe executive function in mild cognitive impairment
Yuri Matsuzaki; Hidetoshi Omiya; Maki Miyajima
The 22nd WPA World Congress of Psychiatry, 03 Aug. 2022, English, Poster presentation
03 Aug. 2022 - 06 Aug. 2022

全身性エリテマトーデスモデルマウスにおける骨髄神経障害は多臓器障害を悪化させる
齋藤悠城; 宮島真貴; 山本瀬菜; 三浦倫寛; 佐藤吏紗; 北愛里紗; 井嶋翔吾; 藤宮峯子; 千見寺貴子
第43回日本炎症再生学会, 06 Jul. 2022
06 Jul. 2022 - 07 Jul. 2022

フィセチンによる老化細胞除去はMRL/lprマウスのエリテマトーデス様皮膚病変を改善する
山本瀬菜; 齋藤悠城; 井嶋翔吾; 北愛里紗; 三浦倫寛; 佐藤吏紗; 宮島真貴; 千見寺貴子
第43回日本炎症再生学会, 06 Jul. 2022
06 Jul. 2022 - 07 Jul. 2022

Altered regulation of senescence-associated secretory phenotype in hippocampus modulates resilience to chronic mild psychiatric stress
Tsukasa Sato; Yuki Saito; Maki Miyajima; Sena Yamamoto; Norihiro Miura; Mineko Fujimiya; Takako S Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

Fisetin improved depressive behavior in murine lupus by decreasing senescent neural cell
Yuki Saito; Maki Miyajima; Sena Yamamoto; Tsukasa Sato; Norihiro Miura; Mineko Fujimiya; Takako S Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Oral presentation
12 Dec. 2021 - 15 Dec. 2021

Lower-expression of Cdkn2a is associated with dysregulation of fibro-adipogenic progenitors results in skeletal muscle atrophy and degeneration in diabetic mice
Norihiro Miura; Yuki Saito; Arisa Kita; Maki Miyajima; Tsukasa Sato; Sena Yamamoto; Mineko Fujimiya; Takako S Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

Senolysis by fisetin ameliorates lupus erythematosus-like skin lesions in MRL/lpr mice
Sena Yamamoto; Yuki Saito; Shogo Ijima; Arisa Kita; Norihiro Miura; Tsukasa Sato; Maki Miyajima; Mineko Fujimiya; Takako S Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

Dual role of TGF-β1 in cellular senescence of tubular cells and hyper-proliferation of fibroblasts to aggravate lupus nephritis
Shogo Ijima; Yuki Saito; Maki Miyajima; Mineko Fujimiya; Takako S. Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

Accumulation of senescent neurons in mice model of autism spectrum disorder with abnormal synaptic pruning
Maki Miyajima; Yuki Saito; Tsukasa Sato; Norihiro Miura; Sena Yamamoto; Mineko Fujimiya; Takako S. Chikenji
The 6th International Cell Senescence Association Conference, 13 Dec. 2021, Poster presentation
12 Dec. 2021 - 15 Dec. 2021

前頭葉/実行機能プログラム（FEP)を用いて認知機能の改善がみられた軽度認知障害（MCI)の事例
松㟢由莉、宮島真貴、大宮秀淑
第53回日本作業療法学会, Sep. 2019, Poster presentation
06 Sep. 2019 - 08 Sep. 2019

軽度認知障害に対する認知機能改善療法の有効性の検討
松㟢由莉、宮島真貴、大宮秀淑
第8回日本認知症予防学会, Sep. 2018, Poster presentation
22 Sep. 2018 - 24 Sep. 2018

認知機能改善療法の紹介二疾患を対象にした前頭葉/実行機能プログラムの有効性の検討
宮島真貴; 大宮秀淑; 山下聖子; 山家研司; 傳田健三
日本作業療法学会抄録集, Sep. 2017, Japanese

自閉スペクトラム症に対する認知機能改善療法の効果研究 Frontal/Executive Program(FEP)の有効性
宮島真貴; 大宮秀淑; 山下聖子; 山家研司; 傳田健三
北海道児童青年精神保健学会会誌, Nov. 2016, Japanese

自閉スペクトラム症に対するFrontal/Executive Programが有効であった例と、変化が認められなかった症例の比較
宮島真貴; 山下聖子; 山家研司; 松井三枝; 傳田健三
北海道児童青年精神保健学会会誌, Dec. 2015, Japanese

依存症に対するデイケアの取り組み解毒期を過ぎた患者を対象に
宮島真貴; 工藤望; 蓑島千晶; 山下聖子
北海道作業療法, Sep. 2015, Japanese

前頭葉/実行機能プログラムが有効であった成人期自閉スペクトラム症の1例
宮島真貴; 山下聖子; 松井三枝; 山家研司; 傳田健三
日本作業療法学会抄録集, Jun. 2015, Japanese

統合失調症患者における作業記憶障害の神経基盤と介入への示唆
宮島真貴; 豊巻敦人; 宮崎茜; 久住一郎
日本作業療法学会抄録集, Jun. 2013, Japanese

統合失調症患者に対する認知矯正療法の効果神経認知機能とThe Schizophrenia Quality of Life Scale日本語版(JSQLS)の変化から
井上貴雄; 加藤ちえ; 宮島真貴; 豊巻敦人; 橋本直樹
日本作業療法学会抄録集, Jun. 2013, Japanese

認知リハビリテーションをきっかけに福祉的就労につながった一症例 NEARによる実践
加藤ちえ; 井上貴雄; 宮島真貴; 豊巻敦人; 橋本直樹
日本作業療法学会抄録集, Jun. 2013, Japanese

統合失調症におけるrule shiftingの処理過程の解明事象関連電位による検討
宮島真貴; 豊巻敦人; 久住一郎
北海道作業療法, Sep. 2012, Japanese

外来作業療法に通う統合失調症患者に対する認知矯正療法の治療効果について
宮島真貴; 橋本直樹; 豊巻敦人; 久住一郎; 小山司
日本作業療法学会抄録集, Jun. 2012, Japanese

■ Syllabus

臨床実習Ⅱ（作）, 2024年, 学士課程, 医学部

地域・国際母子保健学, 2024年, 修士課程, 保健科学院

生体システム制御学演習, 2024年, 修士課程, 保健科学院

生体システム制御学特論, 2024年, 修士課程, 保健科学院

発達障害学, 2024年, 学士課程, 医学部

臨床実習Ⅲ（作）, 2024年, 学士課程, 医学部

臨床実習Ⅳ（作）, 2024年, 学士課程, 医学部

作業療法評価学総論, 2024年, 学士課程, 医学部

地域リハビリテーション, 2024年, 学士課程, 医学部

臨床実習Ⅰ（作）, 2024年, 学士課程, 医学部

作業療法概論, 2024年, 学士課程, 医学部

基礎作業学, 2024年, 学士課程, 医学部

リハビリテーション管理学, 2024年, 学士課程, 医学部

精神障害学Ⅰ, 2024年, 学士課程, 医学部

基礎作業学実習Ⅱ, 2024年, 学士課程, 医学部

作業療法理論, 2024年, 学士課程, 医学部

精神障害評価学演習, 2024年, 学士課程, 医学部

地域作業療法学実習, 2024年, 学士課程, 医学部

精神障害学Ⅱ, 2024年, 学士課程, 医学部

臨床実習Ⅱ（作）, 2024年, 学士課程, 医学部

作業療法研究法, 2024年, 学士課程, 医学部

作業療法研究法演習, 2024年, 学士課程, 医学部

■ Research Themes

細胞老化に着目した自閉スペクトラム症の病態解明と新規治療探索
科学研究費助成事業若手研究
01 Apr. 2023 - 31 Mar. 2026
宮島真貴
日本学術振興会, 若手研究, 北海道大学, 23K14811