博士（工学）, 大阪大学

センシング

有機合成

化学発光色素

蛍光色素

Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering), Electron device and electronic equipment

Bachelor's degree program, School of Science

Master's degree program, Graduate School of Environmental Science

Doctoral (PhD) degree program, Graduate School of Environmental Science

Mar. 2020, 日本分析化学会, 北海道分析化学賞
構造有機化学の手法を用いた環境によって発光色の変化する蛍光・化学発光プローブの開発
山田幸司

Apr. 2008, 日本化学会第88春季年会優秀講演賞（学術）
山田 幸司

Synthesis of a Fluorescent Solvatochromic Resin Using Suzuki–Miyaura Cross-Coupling and Its Optical Waveguide Spectra to Measure the Solvent Polarity on the Surface
Yu Otsuka; Guanglei Li; Hiromi Takahashi; Hisashi Satoh; Koji Yamada
Materials, 13, 20, 4483, 4492, MDPI AG, 10 Oct. 2020, [Peer-reviewed], [Corresponding author]
Scientific journal, We have established a novel analytical method for solvent polarity on resin surface by combining the synthesis of fluorescent solvatochromic resin with optical waveguide spectrometry. The fluorescent solvatochromic resin was obtained via Suzuki–Miyaura cross-coupling between 4-iodobenzoic acid immobilized on Wang resin and 5-[4-(N,N-dihexylamino)phenyl]-2-thienylboronic acid N-methyl-iminodiacetic acid (MIDA) ester. The optical waveguide spectrometry studies on the resin showed a strong fluorescent solvatochromism in various organic solvents.

Bright near-infrared chemiluminescent dyes: Phthalhydrazides conjugated with fluorescent BODIPYs
Guanglei Li; Takashi Hirano; Koji Yamada
DYES AND PIGMENTS, 178, Jul. 2020, [Peer-reviewed]
English, Scientific journal

A BODIPY-Based Fluorogenic Probe for Specific Imaging of Lipid Droplets.
Guanglei Li; Jianye Li; Yu Otsuka; Shuai Zhang; Masashi Takahashi; Koji Yamada
Materials (Basel, Switzerland), 13, 3, 03 Feb. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, We developed an easily accessible boron-dipyrromethene (BODIPY)-based fluorogenic probe, which we named LD-TB. This probe emits bright fluorescence in oil; when compared with aqueous solution, a significant enhancement of fluorescence brightness is observed. Cellular experiments confirmed that the probe stains the lipid droplets (LDs) specifically in both live and fixed cells, providing background-free images. Compared with Nile Red dye, a commonly used LD marker, LD-TB showed superior photostability. The sharp absorption and emission bands enable its multicolor imaging with blue and green probes. Importantly, the probe has proved to have low toxicity and is compatible with cell fixation. Our research provides a promising new fluorogenic probe for specific imaging of LDs.

A Straightforward Substitution Strategy to Tune BODIPY Dyes Spanning the Near-Infrared Region via Suzuki-Miyaura Cross-Coupling
Li Guanglei; Otsuka Yu; Matsumiya Takuya; Suzuki Toshiyuki; Li Jianye; Takahashi Masashi; Yamada Koji
MATERIALS, 11, 8, Aug. 2018, [Peer-reviewed]

3-[Bis(pyridin-2-ylmethyl)amino]-5-(4-carboxyphenyl)-BODIPY as Ratiometric Fluorescent Sensor for Cu2+
Hafuka, Akira; Satoh, Hisashi; Yamada, Koji; Takahashi, Masahiro; Okabe, Satoshi
MATERIALS, 11, 5, May 2018, [Peer-reviewed]
English, Scientific journal

Interactions of dissolved humic substances with oppositely charged fluorescent dyes for tracer techniques
Hafuka, Akira; Ding, Qing; Yamamura, Hiroshi; Yamada, Koji; Satoh, Hisashi
WATER RESEARCH, 85, 193, 198, Nov. 2015, [Peer-reviewed]
English, Scientific journal

Substituent Effects at the 5-Position of 3-[Bis(pyridine-2-ylmethyl)amino]-BODIPY Cation Sensor Used for Ratiometric Quantification of Cu2+
Akira Hafuka; Ryosuke Kando; Kohei Ohya; Koji Yamada; Satoshi Okabe; Hisashi Satoh
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 88, 3, 447, 454, Mar. 2015, [Peer-reviewed]
English, Scientific journal

Application of fluorescence spectroscopy using a novel fluoroionophore for quantification of zinc in urban runoff
Akira Hafuka; Hiroaki Yoshikawa; Koji Yamada; Tsuyoshi Kato; Masahiro Takahashi; Satoshi Okabe; Hisashi Satoh
WATER RESEARCH, 54, 12, 20, May 2014, [Peer-reviewed]
English, Scientific journal

Determination of Zn²⁺ in industrial wastewater by fluorescence spectroscopy with fluoroionophore
HAFUKA Akira; YOSHIKAWA Hiroaki; OHYA Kohei; YAMADA Koji; TAKAHASHI Masahiro; OKABE Satoshi; SATOH Hisashi
Journal of Japan Society of Civil Engineers, Ser. G (Environmental Research), 69, 7, III_275, III_280, 公益社団法人 土木学会, Nov. 2013, [Peer-reviewed]
Japanese, We applied a novel fluorescent indicator (i.e., fluoroionophore) for industrial wastewater to determine Zn²⁺ by using fluorescence spectroscopy. The fluoroionophore showed red-shifted fluorescence upon Zn²⁺ binding. The indicator exhibited ratiometric fluorescence spectral change with increase of Zn²⁺ concentrations. Zn²⁺ was successfully determined in real industrial wastewater matrix by using the fluoroionophore. In this research, we could demonstrate the potential application of fluorescence spectroscopy with the fluoroionophore to determine heavy metal ions in real wastewater.

Application of POLARIC (TM) fluorophores in an in vivo tumor model
Nako Maishi; Taisuke Kawamoto; Noritaka Ohga; Koji Yamada; Kosuke Akiyama; Kazuyuki Yamamoto; Takahiro Osawa; Yasuhiro Hida; Kyoko Hida
ONCOLOGY REPORTS, 30, 4, 1695, 1700, Oct. 2013, [Peer-reviewed]
English, Scientific journal

BODIPY-Based Ratiometric Fluoroionophores with Bidirectional Spectral Shifts for the Selective Recognition of Heavy Metal Ions
Akira Hafuka; Hiroki Taniyama; Sang-Hyun Son; Koji Yamada; Masahiro Takahashi; Satoshi Okabe; Hisashi Satoh
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 86, 1, 37, 44, Jan. 2013, [Peer-reviewed]
English, Scientific journal

Potential-modulated fluorescence spectroscopy of zwitterionic and dicationic membrane-potential-sensitive dyes at the 1,2-dichloroethane/water interface
Toshiyuki Osakai; Tatsuya Yoshimura; Daichi Kaneko; Hirohisa Nagatani; Sang-Hyun Son; Yutaka Yamagishi; Koji Yamada
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 404, 3, 785, 792, Aug. 2012, [Peer-reviewed]
English, Scientific journal

Design and Synthesis of a Chemiluminescent Solvatochromic Dye
Yutaka Yamagishi; Sang-Hyun Son; Maiko Yuasa; Koji Yamada
CHEMISTRY LETTERS, 41, 5, 504, 506, May 2012, [Peer-reviewed]
English, Scientific journal

Spectral Shifts of the Environment-sensitive Fluorophore POLARIC (TM) in Heterogeneous Interfaces
Sang-Hyun Son; Yutaka Yamagishi; Michiko Tani; Maiko Yuasa; Koji Yamada
CHEMISTRY LETTERS, 40, 9, 989, 991, Sep. 2011, [Peer-reviewed]
English, Scientific journal

A Systematic Analysis of Aromatic Heterocyclic Rings in Solvatochromic Fluorophores
Sang-Hyun Son; Yuko Abe; Maiko Yuasa; Yutaka Yamagishi; Naoki Sakai; Tokiyoshi Ayabe; Koji Yamada
CHEMISTRY LETTERS, 40, 4, 378, 380, Apr. 2011, [Peer-reviewed]
English, Scientific journal

A ratiometric fluorescent pH glass optode based on a boron-dipyrromethene derivative
Yosuke Ando; Shinji Iino; Koji Yamada; Keitaro Umezawa; Naoko Iwasawa; Daniel Citterio; Koji Suzuki
SENSORS AND ACTUATORS B-CHEMICAL, 121, 1, 74, 82, Jan. 2007, [Peer-reviewed]
English, Scientific journal

Photoswitchable magnetic nanoparticles of Prussian blue with amphiphilic azobenzene
M Taguchi; K Yamada; K Suzuki; O Sato; Y Einaga
CHEMISTRY OF MATERIALS, 17, 17, 4554, 4559, Aug. 2005
English, Scientific journal

Highly sodium-selective fluoroionophore based on conformational restriction of oligoethyleneglycol-bridged biaryl boron-dipyrromethene
K Yamada; Y Nomura; D Citterio; N Iwasawa; K Suzuki
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127, 19, 6956, 6957, May 2005
English, Scientific journal

Reversible photo-switching of the magnetization of iron oxide nanoparticles at room temperature
Mikami Rie; Taguchi Minori; Yamada Koji; Suzuki Koji; Sato Osamu; Einaga Yasuaki
Angewandte Chemie - International Edition, 43, 45, 6135, 6139, 19 Nov. 2004
English, <p>In the solid state at room temperature, reversible control of magnetic properties was achieved with photo-illumination of a composite material made up of γ-Fe₂O₃ nanoparticles encapsulated with n-octylamine and an azobenzene-containing amphiphilic compound (see picture).</p>

Morphological change of giant vesicles triggered by dehydrocondensation reaction
K Takakura; T Toyota; K Yamada; M Ishimaru; K Yasuda; T Sugawara
CHEMISTRY LETTERS, 3, 404, 405, Mar. 2002
English, Scientific journal

Microscopic Investigation of the Novel Self-Reproduction of Giant Vesicles
Toyota T; Takakura K; Yamada K; Ishimaru M; Yasuda K; Sugawara T
Biophysics, 41, 1, S27, The Biophysical Society of Japan General Incorporated Association, 10 Sep. 2001
Japanese

Preparation of BODIPY probes for multicolor fluorescence imaging studies of membrane dynamics
K Yamada; T Toyota; K Takakura; M Ishimaru; T Sugawara
NEW JOURNAL OF CHEMISTRY, 25, 5, 667, 669, 2001, [Peer-reviewed]
English, Scientific journal

Analysis of the autocatalytic self-reproduction of giant liposomes
Toyota T; Yamada K; Takakura K; Yasuda K; Yomo T; Sugawara T
Biophysics, 40, 1, S15, The Biophysical Society of Japan General Incorporated Association, 05 Aug. 2000
Japanese

Supramolecular Complexation of Porphyrin and Quinone with Two Coordination Bonds and Intramolecular Electron Transfer
Hiroshi Imahori; Koji Yamada; Eiichi Yoshizawa; Kiyoshi Hagiwara; Tadashi Okada; Yoshiteru Sakata
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 1, 1, 55, 66, 1997, [Peer-reviewed]
English, Scientific journal

Porphyrin-quinone supramolecule with two coordination bonds
Hiroshi Imahori; Eiichi Yoshizawa; Koji Yamada; Kiyoshi Hagiwara; Tadashi Okada; Yoshiteru Sakata
Journal of the Chemical Society, Chemical Communications, 11, 1133, 1134, 1995, [Peer-reviewed]
English, Scientific journal

変色型ボロンジピロメテン蛍光色素を用いた路面排水中Zn²⁺濃度の定量
羽深昭; 吉川弘晃; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 分析化学討論会講演要旨集, 73rd, 149, 04 May 2013
Japanese

網羅的重金属イオン分析に向けた新規変色型蛍光色素の開発
吉川弘晃; 羽深昭; 菅藤亮輔; 大屋光平; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本水環境学会年会講演集, 47th, 431, 11 Mar. 2013
Japanese

新規変色型蛍光色素を用いた路面排水中亜鉛濃度の定量
菅藤亮輔; 羽深昭; 吉川弘晃; 大屋光平; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本水環境学会年会講演集, 47th, 432, 11 Mar. 2013
Japanese

重金属測定用蛍光色素の理論的分子設計による高感度化
大屋光平; 羽深昭; 菅藤亮輔; 吉川弘晃; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本水環境学会年会講演集, 47th, 692, 11 Mar. 2013
Japanese

新規蛍光分子プローブを用いた環境水中重金属イオン分析
菅藤亮輔; 羽深昭; 吉川弘晃; 大屋光平; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 環境工学研究フォーラム講演集, 49th, 31, 33, 28 Nov. 2012
Japanese

新規変色型蛍光色素を用いた路面排水中亜鉛濃度の定量
吉川弘晃; 菅藤亮輔; 羽深昭; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本分析化学会年会講演要旨集, 61st, 315, 05 Sep. 2012
Japanese

重金属センサアレイに向けた変色型ボロンジピロメテン蛍光色素群の開発
菅藤亮輔; 吉川弘晃; 谷山拓生; 羽深昭; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 分析化学討論会講演要旨集, 72nd, 130, 05 May 2012
Japanese

新規変色型蛍光色素を用いた環境サンプル中の重金属イオン分析
谷山拓生; 羽深昭; 菅藤亮輔; 吉川弘晃; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本水環境学会年会講演集, 46th, 506, 14 Mar. 2012
Japanese

新規変色型蛍光色素を用いたクロムイオン分析
吉川弘晃; 羽深昭; 谷山拓生; 菅藤亮輔; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本水環境学会年会講演集, 46th, 676, 14 Mar. 2012
Japanese

新規変色型蛍光色素を用いた亜鉛イオン分析
羽深昭; 谷山拓生; 菅藤亮輔; 吉川弘晃; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本水環境学会年会講演集, 46th, 622, 14 Mar. 2012
Japanese

変色型ボロンジピロメテン蛍光色素を用いた重金属イオン分析
菅藤亮輔; 吉川弘晃; 谷山拓生; 羽深昭; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 化学系学協会北海道支部冬季研究発表会講演要旨集, 2012, 101, 31 Jan. 2012
Japanese

新規蛍光色素を用いた重金属イオン分析
羽深昭; 谷山拓生; 菅藤亮輔; 吉川弘晃; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 環境工学研究フォーラム講演集, 48th, 214, 216, 25 Nov. 2011
Japanese

重金属イオン分析に向けた新規蛍光色素の開発
菅藤亮輔; 羽深昭; 谷山拓生; 吉川弘晃; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 環境工学研究フォーラム講演集, 48th, 220, 222, 25 Nov. 2011
Japanese

Development of Novel Functional Luminescent Dyes Using Cross-Coupling Reaction
YAMADA Koji, Chemical engineering of Japan, 75, 9, 589, 592, 05 Sep. 2011
化学工学会, Japanese

オンサイト重金属イオン分析に向けた新規変色型蛍光色素の開発
谷山拓生; 羽深昭; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 土木学会年次学術講演会講演概要集(CD-ROM), 66th, ROMBUNNO.VII-192, 05 Aug. 2011
Japanese

新規変色型蛍光色素を用いた水サンプル中重金属イオンの簡易分析
羽深昭; 谷山拓生; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 土木学会年次学術講演会講演概要集(CD-ROM), 66th, ROMBUNNO.VII-191, 05 Aug. 2011
Japanese

重金属イオンの識別が可能な変色型ボロンジピロメテン蛍光色素の開発
谷山拓生; 菅藤亮輔; 羽深昭; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本化学会北海道支部夏季研究発表会講演要旨集, 2011, 150, 01 Jul. 2011
Japanese

変色型ボロンジピロメテン蛍光色素を用いた含水サンプル中での重金属イオンの簡易分析
菅藤亮輔; 谷山拓生; 羽深昭; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本化学会北海道支部夏季研究発表会講演要旨集, 2011, 149, 01 Jul. 2011
Japanese

Visible Detection of Water in Oil Using Solvatochromism of Organic Fluorescent Dye
Ryo Kato; Takahiro Nagasaka; Hongbo Zhou; Sang-Hyun Son; Toshiaki Hattori; Koji Yamada, BUNSEKI KAGAKU, 60, 6, 521, 526, Jun. 2011
Japanese

オンサイト重金属イオン分析に向けた新規変色型蛍光色素の開発
谷山拓生; 羽深昭; 菅藤亮輔; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本水環境学会年会講演集, 45th, 293, 18 Mar. 2011
Japanese

新規変色型蛍光色素を用いた水サンプル中の重金属検出
菅藤亮輔; 羽深昭; 谷山拓生; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本水環境学会年会講演集, 45th, 295, 18 Mar. 2011
Japanese

新規変色型蛍光色素を用いたレシオメトリー測定による重金属イオン分析
羽深昭; 谷山拓生; 菅藤亮輔; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 日本水環境学会年会講演集, 45th, 294, 18 Mar. 2011
Japanese

蛍光色素を用いたレシオメトリー測定による重金属イオン分析
羽深昭; 谷山拓生; 山田幸司; 高橋正宏; 岡部聡; 佐藤久, 環境工学研究フォーラム講演集, 47th, 184, 186, 12 Nov. 2010
Japanese

Development of Functional Chemiluminescent Dyes
YAMADA Koji, 光化学 = Photochemistry, 39, 1, 45, 46, 30 May 2008
Japanese

Fluorescent Molecular Sensors Based on Boron-Dipyrromethene Dye
YAMADA Koji, ぶんせき, 390, 293, 294, 05 Jun. 2007
Japanese

脱水縮合によって変色する蛍光反応インジケータ
第81回日本化学会春季年会, 2002

環境修復の科学と技術
北海道大学大学院環境科学院; 田中, 俊逸; 沖野, 龍文; 藏崎, 正明; 新岡, 正; 高橋, 洋介; 東條, 卓人; 山崎, 健一; 安住, 薫; 石塚, 真由美; 神谷, 裕一; 森川, 正章; 福井, 学; 坂入, 信夫; 古月, 文志; 山田, 幸司; 照井, 教文
北海道大学出版会, Mar. 2007, 9784832981805, vii, 256p, 図版[2]p, Japanese

統合環境分析法実習, 2024年, 修士課程, 環境科学院

環境適応学特論, 2024年, 修士課程, 環境科学院

化学Ⅱ, 2024年, 学士課程, 全学教育

蛍光ソルバトクロミック色素
Patent right, 山田 幸司; 山岸 裕; 綾部 時芳; 孫 尚鉉; 青柳 麻衣子; 平 敏夫, 五稜化学株式会社
特願2010-549509, 04 Feb. 2010
特許第5683967号
23 Jan. 2015
201503091320170131

ケイ光ソルバトクロミック色素
Patent right, 山田 幸司, 五稜化学株式会社
特願2008-261343, 08 Oct. 2008
特開2010-090268, 22 Apr. 2010
特許第5437615号
20 Dec. 2013
201403005942597476

ケイ光ソルバトクロミック色素及びその使用法
Patent right, 山田 幸司, 五稜化学株式会社
特願2008-023492, 04 Feb. 2008
特開2008-291210, 04 Dec. 2008
特許第5319130号
19 Jul. 2013
201303076208661919

蛍光ソルバトクロミック色素
Patent right, 山田 幸司; 山岸 裕; 綾部 時芳; 孫 尚鉉; 青柳 麻衣子; 平 敏夫, 国立大学法人北海道大学
JP2010051624, 04 Feb. 2010
WO2010-090265, 12 Aug. 2010
201203094773219155

ケイ光ソルバトクロミック色素
Patent right, 山田 幸司, 国立大学法人北海道大学
特願2008-261343, 08 Oct. 2008
特開2010-090268, 22 Apr. 2010
201003069584420045

ケイ光ソルバトクロミック色素及びその使用法
Patent right, 山田 幸司, 国立大学法人 北海道大学
特願2008-023492, 04 Feb. 2008
特開2008-291210, 04 Dec. 2008
200903096333515035

化学発光性化合物及びそれから成る標識剤
Patent right, 鈴木 孝治; 山田 幸司; 佐藤 朱美, 財団法人神奈川科学技術アカデミー
特願2006-061786, 07 Mar. 2006
特開2007-238489, 20 Sep. 2007
200903015731155456

化学発光性化合物及びそれから成る標識剤
Patent right, 鈴木 孝治; 山田 幸司; 佐藤 朱美, 財団法人神奈川科学技術アカデミー
特願2005-129094, 27 Apr. 2005
特開2006-306752, 09 Nov. 2006
200903019362083689