Researcher basic information

• Ph.D., Nara Institute of Science and Technology, Mar. 2018
• MSc, Nara Institute of Science and Technology, Mar. 2014
• D.D.S., Hokkaido University, Mar. 2011

• https://researchmap.jp/tomohiko-yoshizawa?lang=en

• https://orcid.org/0000-0001-6232-5941
• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201801016388905192
• https://sites.google.com/site/tomohikoyoshizawa/

• https://orcid.org/0000-0001-6232-5941

• 201801016388905192

• reward prediction
• ventral tegmental area
• dopamine
• Striatum
• Striosome
• Matrix
• Reinforcement Learning
• Area postrema

• Life Science, Neuroscience-general
• Life Science, Oral biological science

• Bachelor's degree program, School of Dental Medicine
• Doctoral (PhD) degree program, Graduate school of Dental Medicine

Research activity information

• Jul. 2025, The Japan Neuroscience Society, Neuroscience Research (NSR) Paper Award（NSR Excellent Paper Award）
  Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice
  Tomohiko Yoshizawa, Official journal, Japan, 36792500
• Jan. 2023, Japanese Neural Network Society, Winter Workshop on Mechanism of Brain and Mind 2023 Excellent Poster Award
  Tomohiko Yoshizawa, 36792500;13226328
• Sep. 2021, 第101回日本生理学会北海道地方会 優秀発表賞
  Tomohiko Yoshizawa, 13226328

• Neural correlates of licking behavior modulated by target position in the striatal matrix compartment
  Taishi Kimoto†; Tomohiko Yoshizawa†; Yuta Ishimaru; Tadashi Inui; Koichi Nakamura; Yasutaka Yawaka; Makoto Funahashi; †Contributed equally
  Neuroscience, 615, 158, 168, Elsevier BV, 03 Nov. 2026, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal, 49755545;36792500
• Neural responses prior to licking onset in the striatal matrix compartment in mice
  Yuta Ishimaru†; Tomohiko Yoshizawa†; Taishi Kimoto; Tadashi Inui; Yasutaka Yawaka; Makoto Funahashi; †Contributed equally
  Neuroscience, 589, 195, 204, Elsevier BV, 25 Oct. 2025, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal, 49755545;36792500;42865209;42624390
• Basolateral amygdala inhibition reduces avoidance in conditioned taste aversion—Transient chemogenetic silencing shifts behavior toward sustained licking
  Tadashi Inui; Emi Kikuchi; Yuto Suzuki; Momoko Hasegawa; Zimo Wei; Helai Huang; Tomohiko Yoshizawa; Makoto Funahashi
  Behavioural Brain Research, 495, 115784, 115784, Elsevier BV, Oct. 2025, [Peer-reviewed]
  English, Scientific journal
• Taste preference and conditioned taste aversion of the metallothionein-1/2 null mice
  Nanae Yasuura; Tadashi Inui; Tomohiko Yoshizawa; Norio Sogawa; Yoshiaki Sato; Makoto Funahashi
  Physiology & Behavior, 114757, 114757, Elsevier BV, 27 Nov. 2024, [Peer-reviewed]
  English, Scientific journal, 38536716
• Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice (NSR Excellent Papar Award)
  Tomohiko Yoshizawa; Makoto Funahashi
  Neuroscience Research, 212, 61, 68, Elsevier BV, 07 Nov. 2024, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal, 36792500
• Conditioned nausea induced by cisplatin and emetine identified by a taste reactivity test in rats.
  Shaoyi Su; Zimo Wei; Helai Huang; Tomohiko Yoshizawa; Tadashi Inui; Makoto Funahashi
  Physiology & Behavior, 114278, 114278, Elsevier BV, 21 Jun. 2023, [Peer-reviewed]
  English, Scientific journal
• Neuronal Representation of a Working Memory-Based Decision Strategy in the Motor and Prefrontal Cortico-Basal Ganglia Loops
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  eNeuro, 10, 6, ENEURO.0413, 22.2023, Society for Neuroscience, 01 Jun. 2023, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal, Abstract
  
  While animal and human decision strategies are typically explained by model-free and model-based reinforcement learning (RL), their choice sequences often follow simple procedures based on working memory (WM) of past actions and rewards. Here, we address how working memory-based choice strategies, such as win-stay-lose-switch (WSLS), are represented in the prefrontal and motor cortico-basal ganglia loops by simultaneous recording of neuronal activities in the dorsomedial striatum (DMS), the dorsolateral striatum (DLS), the medial prefrontal cortex (mPFC), and the primary motor cortex (M1). In order to compare neuronal representations when rats employ working memory-based strategies, we developed a new task paradigm, a continuous/intermittent choice task, consisting of choice and no-choice trials. While the continuous condition (CC) consisted of only choice trials, in the intermittent condition (IC), a no-choice trial was inserted after each choice trial to disrupt working memory of the previous choice and reward. Behaviors in CC showed high proportions of win-stay and lose-switch choices, which could be regarded as “a noisy WSLS strategy.” Poisson regression of neural spikes revealed encoding specifically in CC of the previous action and reward before action choice and prospective coding of WSLS action during action execution. A striking finding was that the DLS and M1 in the motor cortico-basal ganglia loop carry substantial WM information about previous choices, rewards, and their interactions, in addition to current action coding., 13226328;36792500
• Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia
  Tomohiko Yoshizawa; Yuuto Miyamura; Yuta Ochi; Riichiro Hira; Makoto Funahashi; Yutaka Sakai; Yilong; Cui; Yoshikazu Isomura
  bioRxiv, Cold Spring Harbor Laboratory, 06 Mar. 2023, [Lead author, Corresponding author]
  English, Abstract
  
  Animals optimize their actions by predicting and verifying their outcomes (e.g., rewards). Reward prediction often requires working memory (WM)-based information. To elucidate the neural basis of WM-based reward prediction, we compared the activity of dopamine (DA) neurons in the ventral tegmental area (VTA) in an alternate reward condition (WM-based) with that in a random (WM-free) reward condition in rats and mice. Positron emission tomography revealed greater VTA activation in the WM-based than the WM-free condition. Lateral and medial VTA neurons displayed differential electrophysiological spike activities reflecting WM-based and WM-free reward prediction error, respectively. Furthermore, phasic DA release in the dorsal and ventral striatum changed as WM-based and WM-free classical conditioning progressed. Consistent with our WM-based model, reward acquisition caused a DA dip only in the dorsal striatum. Thus a dual DA system processes WM-based and WM-free reward prediction in parallel., 36792500;13226328
• Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats.
  Shaoyi Su; Mayu Fujita; Zimo Wei; Heligh Huang; Tomohiko Yoshizawa; Tadashi Inui; Makoto Funahashi
  Physiology & behavior, 113565, 113565, 27 Aug. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, We investigated the effect of area postrema lesions and selective vagotomy of afferent fibers on emetine-induced nausea in rats. We evaluated the acquisition of the conditioned taste avoidance (CTA) to 0.1% saccharin solution after conditioning with emetine dihydrochloride (5.54 mg/kg, i.p., 1% BW). The CTA was measured in three groups of rats: a bilateral subdiaphragmatic afferent vagotomy group, an area postrema lesion group, and a sham lesion group. The bilateral vagotomy and sham groups of rats showed acquisition of CTA within 2 days of the test date. Taste avoidance was never conditioned in the area postrema lesion group. These results indicate that the area postrema plays a crucial role in the induction of emetine-induced nausea.
• An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping.
  Shun Hamada†; Masashi Nagase†; Tomohiko Yoshizawa†; Akari Hagiwara†; Yoshikazu Isomura; Ayako M Watabe; Toshihisa Ohtsuka; †Contributed equally
  Communications biology, 4, 1, 461, 461, 12 Apr. 2021, [Peer-reviewed], [Lead author], [International Magazine]
  English, Scientific journal, Optogenetic tools such as channelrhodopsin-2 (ChR2) enable the manipulation and mapping of neural circuits. However, ChR2 variants selectively transported down a neuron's long-range axonal projections for precise presynaptic activation remain lacking. As a result, ChR2 activation is often contaminated by the spurious activation of en passant fibers that compromise the accurate interpretation of functional effects. Here, we explored the engineering of a ChR2 variant specifically localized to presynaptic axon terminals. The metabotropic glutamate receptor 2 (mGluR2) C-terminal domain fused with a proteolytic motif and axon-targeting signal (mGluR2-PA tag) localized ChR2-YFP at axon terminals without disturbing normal transmission. mGluR2-PA-tagged ChR2 evoked transmitter release in distal projection areas enabling lower levels of photostimulation. Circuit connectivity mapping in vivo with the Spike Collision Test revealed that mGluR2-PA-tagged ChR2 is useful for identifying axonal projection with significant reduction in the polysynaptic excess noise. These results suggest that the mGluR2-PA tag helps actuate trafficking to the axon terminal, thereby providing abundant possibilities for optogenetic experiments.
• Effects of methyl methacrylate on the excitability of the area postrema neurons in rats.
  Tomohiko Yoshizawa; Makoto Funahashi
  Journal of oral biosciences, 62, 4, 306, 309, Dec. 2020, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, OBJECTIVES: The aim of the present study is to demonstrate the effects of inhaled methyl methacrylate (MMA) on the excitability of neurons in the area postrema (AP). We also investigated the relation between vagal afferent inputs and responding cells in the AP. METHODS: We set up two groups of experimental animals, such as rats inhaling MMA and rats inhaling room air. To visualize the changes of AP neuron excitability after inhalation of MMA for 90 min, c-Fos protein expression was identified and quantified by immunohistochemical analysis. Some rats receiving ventral gastric branch vagotomy were also subjected to the abovementioned experiment. RESULTS: The number of c-Fos-immunoreactive (Fos-ir) cells in the MMA group was more than six times greater than that of the control group (statistically significant, p < 0.01). In vagotomized rats inhaling MMA, markedly smaller number of Fos-ir cells was identified in the AP compared to that of rats inhaling MMA without vagotomy. CONCLUSIONS: These results indicate that inhalation of MMA increases neuronal excitability in the AP, suggesting that vagal afferent inputs are involved in the induction mechanism of Fos-ir cells by MMA., 13226328
• Reward-predictive neural activities in striatal striosome compartments
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  eNeuro, 5, 1, Society for Neuroscience, 29 Jan. 2018, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal

• Neural correlates of licking behavior modulated by target position in the striatal matrix compartment
  Taishi Kimoto†; Tomohiko Yoshizawa†; Yuta Ishimaru; Tadashi Inui; Koichi Nakamura; Yasutaka Yawaka; Makoto Funahashi; †Contributed equally, bioRxiv, 21 Apr. 2026, [Lead author, Corresponding author]
  Abstract
  
  The striatum is a major cortical input site of the basal ganglia and plays a critical role in the control of orofacial movements such as licking. However, how striatal activity relates to the spatial features of licking behavior remains unclear. In this study, we examined whether neural activity in the striatal matrix and striosomal compartments is associated with the spatial position of a licking target during an operant task. Head-fixed mice performed a licking task in which the target positions were varied across three spatial dimensions. Using fiber photometry in Calb1-IRES-Cre and Pdyn-IRES-Cre mice, we recorded calcium signals from matrix and striosomal neurons. Associations between neural activity, target position, and behavioral variables were quantified using linear mixed-effects modeling with cross-validation. Matrix activity prior to licking onset was primarily associated with the dorsal–ventral target position and reaction time. During licking, matrix activity was modulated by anterior–posterior and medial–lateral positions, independent of reaction time and lick count. In contrast, striosomal activity during licking was predominantly associated with the dorsal–ventral position. These findings demonstrate that neural matrix activity is systematically associated with spatial features of licking behavior, with distinct contributions before and during movement. Our results suggest that striatal matrix circuits provide task-relevant spatial signals for the control of orofacial actions.
  
  Significant Statement
  
  We show that neural activity in the striatal matrix is associated with the three-dimensional position of a licking target during an operant task. Activity prior to licking onset reflects dorsal–ventral position, whereas activity during licking is modulated by the anterior–posterior and medial–lateral positions. These findings indicate that matrix activity represents spatial aspects of licking behavior, supporting a role for the striatum in integrating motor execution with task-specific spatial information and pointing to the matrix compartment as a substrate for transforming spatial coordinates into action-specific motor commands., openRxiv, English, 49755545;36792500
• Neural responses prior to licking onset in the striatal matrix compartment in mice
  Yuta Ishimaru†; Tomohiko Yoshizawa†; Taishi Kimoto; Tadashi Inui; Yasutaka Yawaka; Makoto Funahashi; †Contributed equally, bioRxiv, 28 May 2025, [Lead author, Corresponding author]
  Abstract
  
  Licking is a continuous tongue thrust observed during drinking in rodents and humans and is often studied as an essential tongue movement for feeding and swallowing. The striatum, a component of the basal ganglia, plays a critical role in licking onset; however, it is unclear how the two compartments of the striatum—the matrix and striosomes—contribute to the control of licking onset. In this study, we used male and female transgenic mice that selectively expressed Cre recombinase in matrix or striosome neurons and subjected them to operant conditioning based on licking of a spout, during which neuronal activity in both compartments was measured using fiber photometry. Only matrix neurons showed responses prior to licking onset. In addition, the matrix neural response before licking onset was larger when mice licked a spout ipsilateral to the recording hemisphere of the brain than that observed when licking the contralateral spout. This response was observed similarly in mice conditioned to receive a reward regularly and those conditioned to receive a reward randomly, suggesting that the response was unrelated to whether the reward was predictable or unpredictable. Matrix neural activity was negatively correlated with the number of licks during the water intake behavior following the first lick. These findings suggest that matrix neurons are involved in the preparatory process for licking onset as well as in the regulation of licking frequency during water intake.
  
  Significant Statement
  
  This study demonstrated that during the expression of operant conditioning behaviors based on licking, striatal matrix neurons showed responses prior to licking onset. Additionally, these responses were larger when the mouse licked the spout ipsilateral to the brain hemisphere undergoing recording than when a spout in the contralateral direction was licked. This result was also true for mice conditioned using either regular or random reward conditions. Additionally, the number of licks during water ingestion behavior following the initial lick was negatively correlated with matrix neuron activity. These changes in matrix neuron activity are suggested to be involved in the preparatory process for licking onset, independent of reward prediction, and in the regulation of licking frequency during drinking., Cold Spring Harbor Laboratory, English, Technical report, 49755545;36792500;42865209;42624390
• The Basolateral Amygdala Mediates Aversive and Fearful Taste Memory
  Tadashi Inui; Emi Kikuchi; Yuto Suzuki; Momoko Hasegawa; Zimo Wei; Helai Huang; Tomohiko Yoshizawa; Makoto Funahashi, 2025
  Elsevier BV
• Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice
  Tomohiko Yoshizawa; Makoto Funahashi, bioRxiv, 19 Sep. 2024, [Lead author, Corresponding author]
  Abstract
  
  The striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. Striosomes comprise approximately 15% of the striatum by volume and are distributed mosaically. Therefore, it is difficult to selectively record dopamine dynamics in striosomes using traditional neurochemical measurements in behaving animals, and it is unclear whether distinct dynamics play a role in associative learning. In this study, we used transgenic mice selectively expressing Cre in striosomal neurons, combined with a fiber photometry technique, to selectively record dopamine release in striosomes during classical conditioning. Water-restricted mice could distinguish the conditioned stimulus (CS) associated with saccharin water from the air-puff-associated CS. The air-puff-associated CS evoked phasic dopamine release only in striosomes. Furthermore, air puff presentation induced dopamine release to striosomal neurons but suppressed release to putative matrix neurons. These findings suggest that dopamine is released in a differential manner in striosomes and the matrix in behaving animals and that dopamine release in striosomes is preferentially induced by the air-puff-associated CS and air puff presentation. These findings support the hypothesis that striosomal neurons play a dominant role in aversive stimuli prediction.
  
  Highlights
  
  Dopamine (DA) release was successfully measured in striosomes of behaving mice.
  
  A conditioned stimulus for aversive outcomes induced DA release in striosomes.
  
  In striosomes, rewarding and aversive unconditioned stimuli triggered DA release., Cold Spring Harbor Laboratory, English, Technical report, 36792500
• Neuronal representation of a working memory-based decision strategy in the motor and prefrontal cortico-basal ganglia loops
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya, bioRxiv, 07 Sep. 2022, [Lead author, Corresponding author]
  Abstract
  
  While animal and human decision strategies are typically explained by model-free and model-based reinforcement learning, their choice sequences often follow simple procedures based on working memory of past actions and rewards. Here we address how working memory-based choice strategies, such as win-stay-lose-switch (WSLS), are represented in the prefrontal and motor cortico-basal ganglia loops by simultaneous recording of neuronal activities in the dorsomedial striatum (DMS), the dorsolateral striatum (DLS), the medial prefrontal cortex (mPFC), and the primary motor cortex (M1). In order to compare neuronal representations when rats employ working memory-based strategies, we developed a new task paradigm, a continuous/intermittent choice task, consisting of choice and no-choice trials. While the continuous condition (CC) consisted of only choice trials, in the intermittent condition (IC), a no-choice trial was inserted after each choice trial to disrupt working memory of the previous choice and reward. Behaviors in CC showed high proportions of win-stay and lose-switch choices, which could be regarded as “a noisy WSLS strategy.” Poisson regression of neural spikes revealed encoding specifically in CC of the previous action and reward before action choice and prospective coding of WSLS action during action execution. A striking finding was that the DLS and M1 in the motor cortico-basal ganglia loop carry substantial WM information about previous choices, rewards, and their interactions, in addition to current action coding.
  
  Significance Statement
  
  Working memory-based decision strategies, such as win-stay-lose-switch (WSLS), are widely observed in humans and animals. To address neuronal bases of these strategies, we recorded neuronal activities of rat prefrontal and motor cortico-basal ganglia loops during continuous/intermittent choice tasks. The rat choice strategy was a noisy WSLS in the continuous choice condition, whereas non-WSLS was selected in the intermittent choice condition. In the continuous choice condition, the primary motor cortex and the dorsolateral striatum in the motor loop more strongly conveyed information about previous choices, rewards, and their interactions than the medial prefrontal cortex and the dorsomedial striatum in the prefrontal loop. These results demonstrate that the motor cortico-basal ganglia loop contributes to working memory-based decision strategies., Cold Spring Harbor Laboratory, English, Technical report, 36792500;13226328

• 風味嫌悪学習による条件刺激への接近行動とリック行動の変化
  青山 佳仁; 乾 賢; 吉澤 知彦; 舩橋 誠
  令和8年度日本生理学会北海道地方会, 29 Aug. 2026, Japanese, Oral presentation
  29 Aug. 2026 - 29 Aug. 2026
• うま味摂取経験によって形成されるうま味嗜好性のメカニズム解明
  長谷川桃子; 乾 賢; 吉澤 知彦; 舩橋 誠
  令和8年度日本生理学会北海道地方会, 29 Aug. 2026, Japanese, Oral presentation
  29 Aug. 2026 - 29 Aug. 2026
• 本学歯学部における「学生による臨床実習評価」 24年間のデータ分析
  根岸 淳; 吉澤 知彦; 松田 彩; 中村 光一; 坂口 究; 佐藤 嘉晃; 八若 保孝; 飯村 忠浩
  第45回日本歯科医学教育学会総会及び学術大会, Aug. 2026, Japanese, Poster presentation
  21 Aug. 2026 - 22 Aug. 2026
• 線条体マトリックス区画における舌運動方向の神経相関
  吉澤 知彦; 木本 大視; 石丸 佑太; 乾 賢; 舩橋 誠
  第103回日本生理学会大会, 12 Mar. 2026, English, Poster presentation
  10 Mar. 2026 - 12 Mar. 2026, 49755545;36792500;42865209;42624390
• 性周期が雌性ラットの塩味嗜好に及ぼす影響
  乾 賢; 長谷川 桃子; 青山 佳仁; 石丸 佑太; 鈴木 悠人; 吉澤 知彦; 舩橋 誠
  第103回日本生理学会大会, 12 Mar. 2026, English, Poster presentation
  10 Mar. 2026 - 12 Mar. 2026
• 舌運動関連神経活動の線条体コンパートメント間比較研究
  石丸 佑太; 吉澤 知彦; 木本 大視; 乾 賢; 八若 保孝; 舩橋 誠
  第11回北大・部局横断シンポジウム, 02 Oct. 2025, English, Poster presentation
  02 Oct. 2025 - 02 Oct. 2025, 49755545;36792500;42865209;42624390
• 連合学習時の線条体ストリオソーム区画におけるドーパミン分泌動態
  吉澤 知彦; 舩橋 誠
  第105回日本生理学会北海道地方会, 27 Sep. 2025, Japanese, Oral presentation
  27 Sep. 2025 - 27 Sep. 2025, 36792500;49931057
• 舌側方運動距離に相関する線条体マトリックス神経活動
  木本 大視; 吉澤 知彦; 石丸 佑太; 乾 賢; 舩橋 誠
  第105回日本生理学会北海道地方会, 27 Sep. 2025, Japanese, Oral presentation
  27 Sep. 2025 - 27 Sep. 2025, 49755545;36792500;42865209;42624390
• 舌運動制御における線条体マトリックス・ストリオソームの機能的差異
  石丸 佑太; 吉澤 知彦; 木本 大視; 乾 賢; 八若 保孝; 舩橋 誠
  第105回日本生理学会北海道地方会, 27 Sep. 2025, Japanese, Oral presentation
  27 Sep. 2025 - 27 Sep. 2025, 36792500;49755545;42624390;42865209
• 視床下部外側野の神経活動抑制が味覚嫌悪学習の表出に及ぼす影響
  乾 賢; 長谷川 桃子; 鈴木 悠人; 吉澤 知彦; 舩橋 誠
  2025年度日本味と匂学会第59回大会, 09 Sep. 2025, Poster presentation
  08 Sep. 2025 - 10 Sep. 2025
• うま味嗜好獲得メカニズム解明に向けた行動実験パラダイムの確立
  乾 賢; 長谷川 桃子; 石丸 佑太; 吉澤 知彦; 舩橋 誠
  第67回歯科基礎医学会学術大会, 06 Sep. 2025, Japanese, Poster presentation
  05 Sep. 2025 - 07 Sep. 2025
• Correlation between tongue movement direction and neural activity in the striatal matrix compartment
  Tomohiko Yoshizawa; Taishi Kimoto; Yuta Ishimaru; Tadaashi Inui; Makoto Funahashi
  The 67th Annual Meeting of Japanese Association for Oral Biology, 06 Sep. 2025, English, Poster presentation
  05 Sep. 2025 - 07 Sep. 2025, 49755545;36792500;42865209;42624390
• Neural activities regulating tongue movements in the striatal matrix and striosome compartments
  Yuta Ishimaru; Tomohiko Yoshizawa; Taishi Kimoto; Tadashi Inui; Makoto Funahashi
  The 67th Annual Meeting of Japanese Association for Oral Biology, 05 Sep. 2025, English, Poster presentation
  05 Sep. 2025 - 07 Sep. 2025, 49755545;36792500;42865209;42624390
• Single-nucleus transcriptomic and spatial analysis of dopaminergic neurons encoding temporally distinct reward predictions
  Kyohei Fujita; Tomohiko Yoshizawa; Yasuhiro Go; Yoshikazu Isomura
  The 48th Annual Meeting of the Japan Neuroscience Society, 26 Jul. 2025, English, Poster presentation
  47856865;43086143
• Possible roles for the striatal matrix and striosome compartments in the control of tongue movements
  Tomohiko Yoshizawa; Yuta Ishimaru; Taishi Kimoto; Tadashi Inui; Makoto Funahashi
  The 48th Annual Meeting of the Japan Neuroscience Society, 25 Jul. 2025, English, Poster presentation
  49755545;36792500;42865209;42624390
• Differential Roles of Glutamatergic and GABAergic Neurons in the Lateral Hypothalamus during Conditioned Taste Aversion Memory Retrieval
  Tadashi Inui; Yuto Suzuki; Zimo Wei; Helai Huang; Tomohiko Yoshizawa; Makoto Funahashi
  第102回日本生理学会大会, 17 Mar. 2025, English, Poster presentation
• 味覚嫌悪学習の想起に伴う視床室傍核から扁桃体基底外側核への入力
  鈴木 悠人; 乾 賢; 魏 紫茉; 黄 鶴来; 吉澤 知彦; 舩橋 誠
  第66回歯科基礎医学会学術大会, 03 Nov. 2024, Japanese, Poster presentation
• 甘味嫌悪記憶による摂食抑制にセロトニン受容体を介する神経活動が関与する可能性
  魏 紫茉; 黄 鶴来; 吉澤 知彦; 乾 賢; 舩橋 誠
  第66回歯科基礎医学会学術大会, 03 Nov. 2024, Japanese, Poster presentation
• Possible involvement of the nervous system for conditioned taste aversion in the mechanism of feeding disorder
  Z. Wei; H. Huang; T. Yoshizawa; T. Inui; M. Funahashi
  Society for Neuroscience Neuroscience 2024, 08 Oct. 2024, English, Poster presentation
  38536716
• 記憶を手がかりとする報酬予測における大脳基底核ドーパミン系の役割
  吉澤 知彦; 宮村 裕人; 越智 裕太; 平 理一郎; 舩橋 誠; 酒井 裕; 崔 翼龍; 礒村 宜和
  第104回日本生理学会北海道地方会, 07 Sep. 2024, Japanese, Oral presentation
  07 Sep. 2024 - 07 Sep. 2024, 36792500;43086143;42616086
• 視床室傍核ニューロンの味覚刺激に対する応答特性と味覚嫌悪学習の想起における役割
  鈴木 悠人; 乾 賢; 魏 紫茉; 黄 鶴来; 吉澤 知彦; 佐藤 嘉晃; 舩橋 誠
  第104回日本生理学会北海道地方会, 07 Sep. 2024, Japanese, Oral presentation
• 記憶を手がかりとする報酬予測における橋被蓋網様核の役割
  木本 大視; 吉澤 知彦; 舩橋 誠
  第104回日本生理学会北海道地方会, 07 Sep. 2024, Japanese, Oral presentation
  47856865;36792500
• Distinct dopamine dynamics in the striatal striosome and matrix compartments during operant conditioning
  Tomohiko Yoshizawa; Makoto Funahashi
  Neuro2024, 24 Jul. 2024, English, Poster presentation
  36792500
• Dopamine dynamics in striatal striosome compartments during classical and operant conditioning
  Tomohiko Yoshizawa; Makoto Funahashi
  Winter Workshop on Mechanism of Brain and Mind 2024, 09 Jan. 2024, English, Poster presentation
  36792500
• Parallel implementation of working and reference memory-based reward prediction in dual dopamine pathway to the striatum
  Tomohiko Yoshizawa; Yuuto Miyamura; Yuta Ochi; Riichiro Hira; Makoto Funahashi; Yutaka Sakai; Yilong Cui; Yoshikazu Isomura
  Society for Neuroscience Neuroscience 2023, 13 Nov. 2023, English, Poster presentation
  10 Nov. 2023 - 15 Nov. 2023, 36792500;42616086
• Distinct dopamine dynamics in the dorsal and ventral striatum during saccharin water intake
  Tomohiko Yoshizawa; Makoto Funahashi
  第65回歯科基礎医学会学術大会, 17 Sep. 2023, English, Poster presentation
  36792500
• Effects of conditioned taste aversion on feeding behavior
  Zimo Wei; Helai Huang; Tomohiko Yoshizawa; Tadashi Inui; Makoto Funahashi
  第65回歯科基礎医学会学術大会, 16 Sep. 2023, English, Poster presentation
  38536716
• Parallel processing of working memory-based and -free reward prediction in dual dopamine system of the basal ganglia
  Tomohiko Yoshizawa; Yuuto Miyamura; Yuta Ochi; Riichiro Hira; Makoto Funahashi; Yutaka Sakai; Yilong Cui; Yoshikazu Isomura
  The 46th Annual Meeting of the Japan Neuroscience Society, 03 Aug. 2023, English, Poster presentation
  36792500;42616086;43086143
• A multi-reservoir model enabling flexible behavior based on the presence of rule without reorganization of neural circuits.
  Yuuto Miyamura; Tomohiko Yoshizawa; Riichiro Hira; Yoshikazu Isomura
  The 100th Anniversary Annual Meeting of The Physiological Society of Japan, 16 Mar. 2023, English, Poster presentation
• Analysis of emetine-induced nausea in rats using a taste reactivity test
  Shaoyi Su; Emi Kikuchi; Zimo Wei; Helai Huang; Tomohiko Yoshizawa; Tadashi Inui; Makoto Funahashi
  The 100th Anniversary Annual Meeting of The Physiological Society of Japan, 14 Mar. 2023, English, Poster presentation
  38536716
• Working memory-based and -free reward prediction in dual dopamine system of the basal ganglia
  Tomohiko Yoshizawa; Yuuto Miyamura; Yuta Ochi; Riichiro Hira; Makoto Funahashi; Yutaka Sakai; Yilong Cui; Yoshikazu Isomura
  The 100th Anniversary Annual Meeting of The Physiological Society of Japan, 14 Mar. 2023, English, Poster presentation
  36792500
• Working memory-based and -free reward prediction in dual dopamine system of the basal ganglia
  Tomohiko Yoshizawa; Yuuto Miyamura; Yuta Ochi; Riichiro Hira; Makoto Funahashi; Yutaka Sakai; Yilong Cui; Yoshikazu Isomura
  Winter Workshop on Mechanism of Brain and Mind 2023, 06 Jan. 2023, English, Poster presentation
  36792500
• 作業記憶に基づく報酬予測を担う神経基盤
  吉澤知彦
  第8回北大・部局横断シンポジウム, 28 Oct. 2022, Japanese, Oral presentation
  36792500
• ゲーピング反応測定によるエメチン誘発条件付け悪心の解析
  蘇 韶懿; 菊池 媛美; 吉澤 知彦; 乾 賢; 舩橋 誠
  第64回歯科基礎医学会学術大会, 17 Sep. 2022, English, Poster presentation
• 若手研究者からみた研究費獲得の意義と申請書の実際
  吉澤 知彦
  若手研究者のための研究費申請書の書き方セミナー, 05 Sep. 2022, Japanese, Oral presentation
  05 Sep. 2022 - 05 Sep. 2022, [Invited]
• A neuronal basis underlying reward prediction based on hidden task rules
  Tomohiko Yoshizawa; Yuuto Miyamura; Yuta Ochi; Riichiro Hira; Makoto Funahashi; Yutaka Sakai; Yilong Cui; Yoshikazu Isomura
  Neuro2022, 02 Jul. 2022, English, Poster presentation
  36792500;42616086
• メタロチオネイン-1，2 欠損マウスの味覚嗜好性の変化
  保浦 七愛; 乾 賢; 蘇 韶懿; 吉澤 知彦; 十川 紀夫; 舩橋 誠
  第63回歯科基礎医学会学術大会, 10 Oct. 2021, English, Poster presentation
• ラットを用いたトラネキサム酸誘発悪心の行動学的解析
  藤田 麻由; 乾 賢; 吉澤 知彦; 舩橋 誠
  第63回歯科基礎医学会学術大会, 10 Oct. 2021, English, Poster presentation
• エメチンおよびシスプラチンによる条件付け味覚忌避における最後野の役割
  蘇 韶懿; 保浦 七愛; 吉澤 知彦; 乾 賢; 舩橋 誠
  第63回歯科基礎医学会学術大会, 09 Oct. 2021, English, Poster presentation
• 作業記憶に基づく意思決定戦略の大脳皮質-基底核回路における神経表現
  吉澤 知彦
  第101回日本生理学会北海道地方会, 11 Sep. 2021, Japanese, Oral presentation
  11 Sep. 2021 - 11 Sep. 2021, 13226328
• An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping
  Shun Hamada; Masashi Nagase; Tomohiko Yoshizawa; Akari Hagiwara; Yoshikazu Isomura; Ayako M Watabe; Toshihisa Ohtsuka
  The 44th Annual Meeting of the Japan Neuroscience Society, 31 Jul. 2021, English, Poster presentation
  13226328
• Neuronal representation of working memory-based decision strategy in the prefrontal and motor cortico-basal ganglia loops
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  The 44th Annual Meeting of the Japan Neuroscience Society, 30 Jul. 2021, English, Poster presentation
  13226328
• Establishment and demonstration of an analytical method to evaluate neuronal activity during sensorimotor transformation
  Masanori Kawabata; Satoshi Nonomura; Tomohiko Yoshizawa; Rios Alain; Tomomi Sakairi; Yutaka Sakai; Yoshikazu Isomura
  The 43rd Annual Meeting of the Japan Neuroscience Society, 30 Jul. 2020, English, Poster presentation
• 大脳基底核による報酬予測と強化学習
  吉澤 知彦
  第12回CBIR若手インスパイアシンポジウム, 12 Feb. 2020, Japanese, Nominated symposium
  12 Feb. 2020 - 12 Feb. 2020, [Invited]
• Modification of motor cortex forelimb lateralization preference in a hemiparkinsonian rat model
  Alain A Rios; Satoshi Nonomura; Tomohiko Yoshizawa; Masanori Kawabata; Tomomi Sakairi; Yutaka Sakai; Yoshikazu Isomura
  Neuro2019, 27 Jul. 2019, English, Poster presentation
• Distribution of sensory/motor-related information in the rat cerebral cortex
  Masanori Kawabata; Satoshi Nonomura; Tomohiko Yoshizawa; Alain Antonio Rios; Tomomi Sakairi; Yutaka Sakai; Yoshikazu Isomura
  Neuro2019, 26 Jul. 2019, English, Poster presentation
• Cell-type specific calcium imaging of striatal neurons in the striosome compartments during an odor-conditioning task
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  Basal Ganglia Gordon Research Conference, Mar. 2018, English, Poster presentation
  11 Mar. 2018 - 16 Mar. 2018
• Neural representation of sensory-state value in the striatal striosome compartment
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  Society for Neuroscience Neuroscience 2017, 14 Nov. 2017, English, Poster presentation
  11 Nov. 2017 - 15 Nov. 2017
• The striatal striosome compartment encodes the value of sensory stimulus
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  Society for Neuroscience Neuroscience 2016, 13 Nov. 2016, English, Poster presentation
  12 Nov. 2016 - 16 Nov. 2016
• Endoscope calcium imaging of rat hippocampus and mouse striatum by miniature microscope
  Makoto Ito; Tomohiko Yoshizawa
  The 8th Optogenetics symposium, 30 Sep. 2016, Japanese, Invited oral presentation
  [Invited], [Domestic Conference]
• The role of striatal patch neurons in reward-based learning
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  The 39th Annual Meeting of the Japan Neuroscience Society, 20 Jul. 2016, English, Poster presentation
• The activities of striatal patch neurons in classical conditioning
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  Winter Workshop on Mechanism of Brain and Mind 2016, 06 Jan. 2016, English, Poster presentation
• The role of the cortico-basal ganglia loops for reward-motivated choice motor behavior
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  The 38th Annual Meeting of the Japan Neuroscience Society, 29 Jul. 2015, English, Poster presentation
• Neural representations of memory-based and value-based decision strategies in the cortico-basal ganglia loops
  Makoto Ito; Tomohiko Yoshizawa; Kenji Doya
  The 38th Annual Meeting of the Japan Neuroscience Society, 28 Jul. 2015, English, Poster presentation
• Dissociation of working memory-based and value-based strategies in a free-choice task
  Makoto Ito; Tomohiko Yoshizawa; Kenji Doya
  The 37th Annual Meeting of the Japan Neuroscience Society, 12 Sep. 2014, English, Poster presentation
• Neural representation of task-level and motor information in the cortico-basal ganglia loops
  Tomohiko Yoshizawa; Makoto Ito; Kenji Doya
  The 37th Annual Meeting of the Japan Neuroscience Society, 11 Sep. 2014, English, Poster presentation

• 口腔生物学と医学, 2024年, 博士後期課程, 歯学院
• 咬合咀嚼生理学研究, 2024年, 博士後期課程, 歯学院
• 摂食行動制御学研究, 2024年, 博士後期課程, 歯学院
• 発表・論文執筆法演習Ⅰ, 2024年, 博士後期課程, 歯学院
• 発表・論文執筆法演習Ⅱ, 2024年, 博士後期課程, 歯学院
• 発表・論文執筆法演習Ⅲ, 2024年, 博士後期課程, 歯学院
• 頭顎口定位制御学, 2024年, 博士後期課程, 歯学院
• 頭顎口定位制御学, 2024年, 博士後期課程, 歯学院
• 頭顎口定位制御学研究, 2024年, 博士後期課程, 歯学院
• 生理学的解析技法, 2024年, 博士後期課程, 歯学院
• 関連臨床医学, 2024年, 学士課程, 歯学部
• 健康と社会, 2024年, 学士課程, 全学教育
• アクティブラーニング科目Ⅰ, 2024年, 学士課程, 歯学部
• 生理学・口腔生理学Ⅰ, 2024年, 学士課程, 歯学部
• 生理学・口腔生理学Ⅱ, 2024年, 学士課程, 歯学部
• 生理学・口腔生理学実習, 2024年, 学士課程, 歯学部

• Oct. 2023 - Present
  Japanese Neural Network Society
• Jul. 2021 - Present
  日本生理学会
• May 2021 - Present
  歯科基礎医学会
• May 2014 - Present
  THE JAPAN NEUROSCIENCE SOCIETY
• Society for Neuroscience (SfN)

• 線条体ストリオソームの縦断的活動計測による構造と神経ダイナミクスの統一理解
  Grants-in-Aid for Scientific Research
  Apr. 2025 - Mar. 2028
  Tomohiko Yoshizawa
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research(C), Hokkaido University, Principal investigator, Competitive research funding, 25K09843
• Neurophysiological study for the elucidation of the difference of the central mechanism of nausea and vomiting and the development of the nausea suppression therapy.
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  01 Apr. 2022 - 31 Mar. 2025
  舩橋 誠; 乾 賢; 吉澤 知彦
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 22K09900
• 記憶を手がかりとする報酬予測を担うドーパミンニューロンサブタイプの同定
  若手研究者のための研究支援制度 共同研究支援制度
  Aug. 2024 - Mar. 2025
  北海道大学, 北海道大学, Principal investigator
• Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice
  国際学術雑誌論文投稿支援事業
  Apr. 2024 - Mar. 2025
  吉澤 知彦
  北海道大学, 北海道大学
• 線条体ストリオソーム/マトリックスの学習時ドーパミンダイナミクスに係る相違の解明
  Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
  Apr. 2022 - Mar. 2025
  Tomohiko Yoshizawa
  Japan Society for the Promotion of Science, Grant-in-Aid for Early-Career Scientists, Hokkaido University, Principal investigator, 22K15217
• 作業記憶依存型報酬予測を担うドーパミンニューロンサブタイプの同定
  若手研究者のための研究支援制度
  Aug. 2023 - Mar. 2024
  北海道大学, 共同研究支援制度, 北海道大学, Principal investigator
• パーキンソン病発症に伴う線条体区画の異常神経活動の同定
  若手研究人材育成事業
  Jul. 2023 - Mar. 2024
  公益財団法人北海道科学技術総合振興センター, 若手研究人材・ネットワーク育成補助金(タレント補助金), 北海道大学, Principal investigator, T-1-28
• パーキンソン病発症に伴う線条体ストリオソーム/マトリックス異常神経活動の同定
  創成若手研究加速支援事業
  Apr. 2023 - Mar. 2024
  Hokkaido University, Hokkaido University, Principal investigator
• Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia
  海外交流助成
  Apr. 2023 - Mar. 2024
  The Ito Foundation, Hokkaido University, Principal investigator
• An electrophysiological study of glucose-sensing mechanism in the area postrema
  研究助成（奨励）
  Apr. 2021 - Mar. 2022
  THE AKIYAMA LIFE SCIENCE FOUNDATION, Hokkaido University, Principal investigator
• Development of brain state extraction method from large-scale neural activity data for brain algorithm estimation
  Grants-in-Aid for Scientific Research (KAKENHI)
  Apr. 2019 - Mar. 2022
  Tomohiko Yoshizawa
  Japan Society for the Promotion of Science (JSPS), Principal investigator, Competitive research funding

• Frontiers in Neural Circuits Review Editor
  Mar. 2021 - 2025
  Peer review
  Peer review etc
• Committee of the 34th Annual Meeting of the Japan Neural Network Society
  2023 - 2024
  Planning etc
  Competition etc
  Japan Neural Network Society

• 【最新脳科学】ドーパミンがあなたの行動を決めている
  08 May 2023
  Other than myself
  株式会社ニューズピックス
  NewsPicks
  ディープな科学, 36792500;13226328, [Internet]

• 2026 - Present
  DEI推進委員（北海道大学 大学院歯学研究院）
• 2023 - Present
  CBT実施専門委員（北海道大学 大学院歯学研究院）
• Apr. 2022 - Present
  FD委員（北海道大学 大学院歯学研究院）
• Jul. 2014 - Mar. 2017
  歯科医院勤務（非常勤）
  歯科医師として診療に従事
• Apr. 2011
  歯科医師免許取得