Researcher basic information

• 博士（歯学）, 東北大学大学院歯学研究科, Sep. 2023

• https://researchmap.jp/yk180281?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202401009666375060

• 202401009666375060

• Bachelor's degree program, School of Dental Medicine
• Doctoral (PhD) degree program, Graduate school of Dental Medicine

Research activity information

• Oct. 2019, sian Academy of Orofacial Pain and Temporomandibular Disorders, SPECIAL AWARD, CASE REPORT CATEGORY
  A case of painful neuropathy in the inferior alveolar nerve due to pericoronitis of lower third molar
  Y.Kudo, F.Honma S.Asoda, W.Muraoka T.Nakagawa K.Wajima
• Mar. 2017, 東北大学, 総長賞

• Dexmedetomidine attenuates nociceptive responses compared with propofol during intravenous sedation for dental surgery: a prospective observational study.
  Saori Tada; Yukie Nitta; Yoko Kudo; Makiko Shibuya; Shigeru Takuma; Kanta Kido
  Journal of dental anesthesia and pain medicine, 26, 2, 121, 132, Apr. 2026, [International Magazine]
  English, Scientific journal, BACKGROUND: Dexmedetomidine (DEX) is an α2-adrenergic agonist widely used for intravenous sedation. Its pharmacological properties suggest autonomic modulatory effects; however, these remain insufficiently characterized during operative procedures. This pilot study compared autonomic responses to surgical stress of DEX and propofol (PPF) during third molar extraction using the Analgesia Nociception Index (ANI), a heart rate variability-derived marker of autonomic balance. METHODS: Adults aged ≥18 years undergoing extraction of mandibular third molars under intravenous sedation were prospectively enrolled. Sedation was maintained with either DEX or PPF infusion following a small pre-induction dose of midazolam. ANI was continuously recorded using a High-Frequency Variability Index module, with a 240-s moving average considered equivalent to ANI. The primary outcome was the minimum ANI value within each predefined 5-min intraoperative interval; percent change from baseline (%Δx) was also calculated to account for interindividual variability. Hemodynamic and respiratory variables were evaluated as secondary outcomes. Protocol deviations or incomplete ANI data prompted exclusion. Between-group comparisons were performed using the Wilcoxon rank-sum test, and p-values were interpreted descriptively given the exploratory study design. RESULTS: Thirty patients were enrolled, 24 (n = 12 per group) of whom were included in the final analysis. The baseline demographics, sedation depth (Ramsay Sedation Scale 3-4), and procedural characteristics were comparable. The minimum intraoperative ANI values were consistently higher with DEX; between-group differences were observed at 5-10, 10-15, 15-20, and 25-30 min after surgery onset (all unadjusted P < 0.05). The %Δx values were positive or near zero with DEX, whereas PPF showed progressively negative values with wider dispersion; ANI values intermittently fell below 50 only in the PPF group. Blood pressure was lower with DEX, whereas cardiorespiratory parameters remained similar. Patient State Index (PSI) during sedation was higher with DEX, but intraoperative PSI values were comparable. CONCLUSION: DEX was associated with greater intraoperative autonomic stability than PPF during intravenous sedation despite similar clinical sedation depths. These findings reflect the distinct pharmacological profiles of both agents. ANI monitoring provides objective insights into autonomic modulatory responses during sedation. Larger randomized trials are required to confirm these preliminary findings.
• Trigeminal Neuropathic Pain With Complicated Pathophysiology Caused by a Low-Level Impacted Mandibular Third Molar: A Case Report
  Yoko Kudo; Seiji Asoda; Wataru Muraoka; Koichi Waijima; Taneaki Nakagawa
  Cureus, 18 May 2025, [Peer-reviewed], [Lead author]
• Anaphylaxis Following a Third Exposure to Sugammadex
  Honoka Ishihara, DDS; Yukie Nitta; DDS, PhD.; Yoko Kudo; DDS, PhD.; Kanta Kido; DDS, PhD.
  Anesthesia progress, Aug. 2024, [Peer-reviewed]
• Differences in prevalence of self-reported oral hypofunction between older adult patients with rheumatoid arthritis and the general older population: A cross-sectional study using propensity score matching.
  Yoko Kudo; Kenji Takeuchi; Taro Kusama; Toshihisa Kojima; Yuko Waguri-Nagaya; Mako Nagayoshi; Katsunori Kondo; Kentaro Mizuta; Ken Osaka; Masayo Kojima
  Journal of oral rehabilitation, 14 Feb. 2024, [Peer-reviewed], [Lead author], [International Magazine]
  English, Scientific journal, OBJECTIVE: To examine the association between rheumatoid arthritis (RA) and oral hypofunction (OHF) using propensity score matching (PSM) to adjust for differences between older adults with RA and the general older adult population. METHODS: We conducted a cross-sectional survey among 189 older adults with RA in 2019 (mean age, 71.9 ± 3.6) and 47 178 independent older adult residents in 2016 (mean age, 71.6 ± 4.0), respectively. The questionnaire covered information on socio-demographic characteristics and OHF for both groups. Age, sex, educational level and smoking history were used to determine PSM. Prevalence ratios (PRs) and 95% confidence intervals (CIs) of self-reported OHF (fewer remaining teeth, decreased masticatory function, deterioration of swallowing function and oral dryness) were estimated using Poisson regressions. RESULT: OHF was observed in 44.4% of patients with RA and 27.5% of residents. Before PSM, the prevalence of OHF among patients with RA was higher than that of residents (PR, 1.75; 95% CI, 1.50-2.05). After PSM, there were 189 patients with RA and residents, and the prevalence of OHF among patients with RA was still higher (PR, 1.61; 95% CI, 1.22-2.13). Poisson regression showed that the prevalence of 19 or fewer teeth (PR, 1.06; 95% CI, 0.82-1.36), difficulties eating tough foods (PR, 1.18; 95% CI, 0.90-1.55), difficulties swallowing tea or soup (PR, 1.77; 95% CI, 1.19-2.63), and dry mouth (PR, 2.79; 95% CI, 1.90-4.07) was higher among patients with RA than residents. CONCLUSION: Compared with the general older adult population, patients with RA have a higher prevalence of self-reported OHF.
• Clinical value of entire-circumferential intraoperative frozen section analysis for the complete resection of superficial squamous cell carcinoma of the tongue.
  Seiji Asoda; Hidetaka Miyashita; Tomoya Soma; Kanako Munakata; Yuka Yamada; Yuta Yasui; Yoko Kudo; Shin Usuda; Toshihiro Hasegawa; Taneaki Nakagawa; Hiromasa Kawana
  Oral oncology, 123, 105629, 105629, Dec. 2021, [International Magazine]
  English, Scientific journal, OBJECTIVES: We aimed to evaluate the clinical value of an entire-circumferential intraoperative frozen section analysis (e-IFSA) for the complete resection of superficial squamous cell carcinoma (SCC) of the tongue. MATERIALS AND METHODS: A total 276 specimens from 51 patients with pT1-2, N0, mucosal or submucosal invasion SCC were analyzed to evaluate the diagnostic accuracy of the e-IFSA and the added value of the e-IFSA to iodine staining. The e-IFSA results were compared with the final histologic results obtained using permanent sections. All specimens for the e-IFSA were taken over the entire circumference 5 mm outside from the iodine unstained areas. The outline of the main resected specimen after taking these outer mucosal specimens were defined as the surgical margins determined by iodine staining alone. RESULTS: The e-IFSA results were in excellent agreement with final histological results (Cohen's kappa value: 0.85) and the e-IFSA showed high sensitivity (100%) and high negative predictive value (100%). The actual complete resection rate with an e-IFSA was 100% (51/51), and no patient required additional resection after surgery. In contrast, 10/51 patients (20%) patients showed residual atypical mucosal epithelium at or beyond the margin determined by iodine staining alone; this difference was statistically significant (P = 0.002). The 5-year local control rate and 5-year overall survival rate after this procedure were both 100%. CONCLUSION: An e-IFSA has additional value when performed in conjunction with iodine staining. An e-IFSA would be useful for achieving complete resection of superficial SCC of the tongue.
• An aspherical microlens assembly for deep brain fluorescence microendoscopy.
  Masaaki Sato; Shotaro Sano; Hiroki Watanabe; Yoko Kudo; Junichi Nakai
  Biochemical and biophysical research communications, 527, 2, 447, 452, 25 Jun. 2020, [International Magazine]
  English, Scientific journal, Fluorescence microendoscopy is becoming a standard technique in neuroscience for visualizing neuronal activity in the deep brain. Gradient refractive index (GRIN) lenses are increasingly used for fluorescence microendoscopy; however, they inherently suffer from strong aberrations and distortion. Aspherical lenses change their radius of curvature with distance from the optical axis and can effectively eliminate spherical aberrations. The use of these lenses has not been fully explored in deep brain fluorescence microendoscopy due to technical difficulties in manufacturing miniature aspherical lenses. In this study, we fabricated a novel microendoscope lens assembly comprised two nested pairs of aspherical microlenses made by precision glass molding. This assembly, which was 0.6 mm in diameter and 7.06 mm in length, was assembled in a stainless steel tube of 0.7 mm outer diameter. This assembly exhibited marked improvements in monochromatic and chromatic aberrations compared with a conventional GRIN lens, and is useful for deep brain fluorescence microendoscopy, as demonstrated by two-photon microendoscopic calcium imaging of R-CaMP1.07-labeled mouse hippocampal CA1 neurons. Our aspherical-lens-based approach offers a non-GRIN-lens alternative for fabrication of microendoscopic lenses.

• 0（ゼロ）から始めて，人の ○（輪）に支えられたペインクリニック
  工藤葉子
  第53回日本歯科麻酔学会総会・学術集会, 11 Oct. 2025, Invited oral presentation
  11 Oct. 2025 - 12 Oct. 2025
• High Frequency Variability Indexを用いた鎮静中の自律神経反応の観察：同一症例におけ るデクスメデトミジンとプロポフォールの使用経験
  新田幸絵; 多田沙織; 高木莉沙; 工藤葉子; 城戸幹太
  第53回日本歯科麻酔学会総会・学術集会, 11 Oct. 2025, Poster presentation
  11 Oct. 2025 - 12 Oct. 2025
• NDB オープンデータから読み取る最近の歯科麻酔のトレンド
  佐々木花乃; 新田幸絵; 工藤葉子; 城戸幹太
  第39回北海道臨床歯科麻酔学会・第40回東日本歯科麻酔学会, 12 Jul. 2025, Oral presentation
• 北海道大学歯学部 5 年生を対象とした卒業後の進路と歯科麻酔学に対する意識調査
  下野成美; 工藤葉子; 城戸幹太
  第39回北海道臨床歯科麻酔学会・第40回東日本歯科麻酔学会, 12 Jul. 2025, Oral presentation
• Sensory Characteristics of the Facial Region in Autism Model Mice
  Yoko Kudo; Masaaki Sato; Kanta Kido
  2025 International Association for Dental, Oral, and Craniofacial Research General Session & Exhibition, English, Poster presentation
  25 Jun. 2025 - 28 Jun. 2025
• レミマゾラム導入時に嘔吐反射と流涎過多を認めた一例
  工藤葉子; 新田幸絵; 城戸幹太
  第52回日本歯科麻酔学会総会・学術集会, Poster presentation
  25 Oct. 2024 - 27 Oct. 2024
• 連続発症した複数の重度歯槽骨吸収部の歯肉溝から歯肉アメーバが検出された一例
  工藤葉子; 杉浦剛; 飯久保正弘
  第33回日本口腔内科学会・第36回日本口腔診断学会・第43回日本歯科薬物療法学会・第32回日本口腔感染症学会4学会合同学術大会, Sep. 2023, Poster presentation
• 初診時に痛みの定位が悪く診断に苦慮した歯原性歯痛の１例,第27回日本口腔顔面痛学会学術大会
  工藤葉子; 庄司憲明; 水田健太郎; 千葉雅俊; 佐々木啓一
  第27回日本口腔顔面痛学会学術大会, Oct. 2022, Poster presentation
• 若年発症成人型糖尿病（MODY３）患者の額矯正手術に対する全身麻酔管理経験
  工藤葉子; 石川実花; 星島宏; 水田健太郎
  第49回日本歯科麻酔学会総会・学術大会, Oct. 2021, Poster presentation
• 歯科麻酔学臨床実習における双方向性オンライン教育プログラムの導入
  工藤葉子; 田中志典; 星島宏; 佐々木詩織; 佐々木晴香; 関口香; 柴田菫; 真藤裕基; 高山紘子; 安田真; 水田健太郎
  第48回日本歯科麻酔学会総会・学術集会, Oct. 2020, Poster presentation
• A case of painful neuropathy in the inferior alveolar nerve due to pericoronitis of lower third molar.
  Y.Kudo; F.Honma; S.Asoda; W.Muraoka; T.Nakagawa; K.Wajima
  19th AAOT＆9th OAPA Scientiffic Mettings, Oct. 2019, English, Poster presentation
• 同種造血幹細胞移植患者における味覚変化に関する臨床的検討.
  清水博之; 池浦一裕; 工藤葉子; 藤田康平; 加藤伸; 加藤淳; 森毅彦; 中川種昭; 角田和之
  日本口腔内科学会第29回総会, Sep. 2019, Oral presentation
• 頭痛が契機となりTMDと診断された「TMDに起因する頭痛」の1例
  臼田頌; 黄地健仁; 工藤葉子; 西須大徳; 池田浩子; 莇生田整冶; 河奈裕正; 中川種昭; 村岡渡
  第32回一般社団法人日本顎関節学会総会・学術大会, Jul. 2019, Poster presentation
• Tooth infection during the chemotherapy for malignant musculoskeletal tumor
  Ymada Y; Asoda S; Nakayama R; Takeuchi T; Kudo Y; Kawana H; Nakagawa T
  MASCC/ISOO, 2019
• 表在性舌癌切除における全周術中迅速病理診断
  莇生田整治; 宮下英高; 相馬智也; 宗像花楠子; 工藤葉子; 中川種昭; 河奈裕正
  第37回日本口腔腫瘍学会・学術大会, Jan. 2019, Invited oral presentation
• 同種造血幹細胞移植患者における唾液分泌量と唾液緩衝能に関する臨床的検討
  池浦一裕; 工藤葉子; 藤田康平; 佐藤英和; 加藤伸; 加藤淳; 森毅彦; 中川種昭; 角田和之
  日本がん口腔支持療法学会第4回学術大会, Dec. 2018, Oral presentation
• 同種造血幹細胞移植周術期における唾液腺機能の臨床的検討
  工藤葉子; 池浦一裕; 藤田康平; 佐藤英和; 加藤伸; 加藤淳; 森毅彦; 中川種昭; 角田和之
  第28回口腔内科学会・第31回口腔診断学会, Sep. 2018, Oral presentation
• レドロン酸およびデノスマブ関連顎骨壊死と有床義歯との関連性に関する臨床的検討
  浅野崇浩; 黄地健仁; 工藤葉子; 岡村衣里子; 臼田頌; 海住直樹; 新部邦透; 岩﨑良太郎; 有馬誠亮; 西山留美子; 鈴木啓介; 鈴木潔; 中川種昭; 堀江伸行
  第127回日本補綴歯科学会学術大会, Jun. 2018, Oral presentation
• マイコプラズマ関連の Stevens-Johnson症候群が強く疑われた一例
  福田 諒; 藤田康平; 加藤 伸; 小高利絵; 池浦一裕; 潮田裕梨; 金生茉莉; 工藤葉子; 小池将人; 佐藤英和; 大内健嗣; 高橋勇人; 中川種昭; 角田和之
  第27回口腔内科学会, Sep. 2017, Oral presentation

• 口腔病態学実習Ⅰ, 2024年, 博士後期課程, 歯学院
• 口腔病態学実習Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔病態学実習Ⅲ, 2024年, 博士後期課程, 歯学院
• 口腔病態学実習Ⅳ, 2024年, 博士後期課程, 歯学院
• 口腔病態学実習Ⅴ, 2024年, 博士後期課程, 歯学院
• 歯科侵襲生体反応解析学, 2024年, 博士後期課程, 歯学院
• 歯科侵襲生体反応防御学研究Ⅰ, 2024年, 博士後期課程, 歯学院
• 歯科周術期管理学, 2024年, 博士後期課程, 歯学院
• 歯科周術期管理学研究Ⅰ, 2024年, 博士後期課程, 歯学院
• 歯科周術期管理学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 歯科侵襲生体反応防御学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 歯科麻酔学, 2024年, 学士課程, 歯学部
• 歯科麻酔学臨床実習Ⅰ, 2024年, 学士課程, 歯学部
• 歯科麻酔学臨床実習Ⅱ, 2024年, 学士課程, 歯学部

• Apr. 2024 - Present
  日本歯科東洋医学会
• Dec. 2022 - Present
  日本障害者歯科学会
• Sep. 2021 - Present
  一般社団法人日本いたみ財団
• Jul. 2019 - Present
  日本顎関節学会
• Aug. 2018 - Present
  日本歯科麻酔学会
• Oct. 2017 - Present
  日本有病者歯科医療学会
• Jul. 2017 - Present
  日本口腔内科学会
• Jun. 2017 - Present
  日本口腔顔面痛学会
• May 2017 - Present
  日本口腔外科学会
• Mar. 2018 - Mar. 2019
  日本補綴歯科学会

• 自閉症モデルマウスの島皮質における顔面痛の情報処理メカニズムの解明
  科学研究費助成事業
  31 Jul. 2024 - 31 Mar. 2026
  工藤 葉子
  日本学術振興会, 研究活動スタート支援, 北海道大学, 24K23605
• 慢性疼痛と発達障害の併存メカニズムの全脳イメージング解析
  Apr. 2025 - Mar. 2026
  公益財団法人 秋山記念生命科学振興財団, Principal investigator
• in vivoカルシウムイメージングを用いた客観的疼痛評価方法の確立
  科学研究費助成事業
  08 Mar. 2023 - 31 Mar. 2024
  工藤 葉子
  2022年度に続き、実験に使用する遺伝子組み換えマウスの繁殖や移送の問題が重なり、実験が当初の計画通りに進まなかった。実験に使用する動物の確保に関する問題を含め、安定した環境で実験を行うことを考えなければならなくなった。2023年9月に博士課程を修了後、2023年10月からPDへ資格変更を行うタイミングを契機に、北海道大学大学院歯学研究院口腔病態学分野歯科麻酔学教室へ所属研究室を変更して研究活動を継続することにした。同大学医学部薬理学分野神経薬理学教室の佐藤正晃先生には、東北大学に所属していた頃から遺伝子組み換えマウスを凍結胚から起こして繁殖させ、飼育をしてもらい、供与していただいた。北海道大学に異動後は、神経薬理学教室と連携を図り、佐藤先生に師事しながら、遺伝子組み換えマウスの繁殖、飼育から自分で行うことになった。佐藤先生には、本研究のメインである二光子顕微鏡を用いたカルシウムイメージングの手技も理化学研究所で研修をしていた頃からご指導をいただいていたので、北海道大学へ異動したことによって、研究計画の相談や実験データのディスカッションが頻繁に行えるようになった。異動の手続きや荷物の搬送、研究環境のセットアップで研究活動が止まった時間も経験したが、研究全体としての進捗速度はこれから上がると考えている。
  学術研究員の期間は、理化学研究所や他大学への研修に行き、カルシウムイメージングの手技や慢性疼痛モデルマウス（眼窩下神経結紮マウス）の作成といった計画実現に必要な一つずつの手技を体得できた。これらを統合させて当初の目標である客観的疼痛評価方法の確立まではこの期間で成果を上げることは無理であったが、習得した技術を活かし、学術研究員の採用修了後も今回採択していただいた研究課題に継続して取り組み、成果が発表できるまで完遂したいと考えている。
  日本学術振興会, 特別研究員奨励費, 22KJ0196

• 日本ACLS協会 BLSインストラクター
  01 Oct. 2023 - 30 Sep. 2027
  Advisor, Organizing member
  日本ACLS協会