Researcher basic information

• PH.D, Tokyo Institute of Technology, Mar. 2010

• https://researchmap.jp/SRyuzaki?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201701011971508348

• 201701011971508348

• Material Science
• Plasmonics
• Nanobiodeviec
• Organic Device

• Nanotechnology/Materials, Analytical chemistry
• Life Science, Biophysics
• Nanotechnology/Materials, Nanobioscience

• Bachelor's degree program, School of Science
• Master's degree program, Graduate School of Chemical Sciences and Engineering
• Doctoral (PhD) degree program, Graduate School of Chemical Sciences and Engineering

Research activity information

• Feb. 2024, プラズモニック化学研究会, 若手奨励賞最優秀賞
• Oct. 2023, 株式会社リバネス, Tech Planter 最優秀賞
  龍崎奏
• Oct. 2023, 大日本印刷株式会社, Tech Planter DNP賞
  龍崎奏
• May 2023, Royal Society of Chemistry, and The Society of Nano Science and Technology, Nanoscale Horizons Award
  Sou Ryuzaki
• Feb. 2023, 北海道未来創造スタートアップ育成相互支援ネットワーク, HSFC Demo Day 優秀賞
  龍崎奏
• Apr. 2022, 科学技術振興機構CREST[細胞外微粒子], Young Innovator Award
• Jul. 2021, DV-Xα研究協会, 奨励賞
• Dec. 2017, IOP Publishing, Nanotechnology, Highlights of 2017
• Aug. 2017, 9th International Conference on Molecular Electronics and Bioelectronics, The Best Poster Award
• Mar. 2016, 第63回応用物理学会春季学術講演会, 講演奨励賞
• Oct. 2010, 財団法人手島工業教育資金団, 手島記念博士論文賞
• Mar. 2007, 東京工業大学原子核工学専攻., 最優秀論文発表賞

• Glomerular routing of tumor-derived extracellular vesicles substantiates urinary biopsy.
  Shota Kawaguchi; Taiga Ajiri; Rina Mitsuya; Reiko Tsuchiya; Koki Kunitake; Yoshikazu Tanaka; Takeshi Yokoyama; Kiichi Sato; Yusuke Sato; Zetao Zhu; Kunanon Chattrairat; Yasuko Kobayashi; Kimiko Inoue; Keisuke Imaeda; Kosei Ueno; Sou Ryuzaki; Akira Kato; Yasuyuki Kimura; Atsushi Natsume; Ryosuke Kojima; Takao Yasui
  Science advances, 12, 8, eaeb0555, 20 Feb. 2026, [International Magazine]
  English, Scientific journal, Urinary small extracellular vesicles (sEVs), which can reflect systemic conditions, hold great promise for noninvasive cancer diagnostics, yet the mechanism by which tumor-derived sEVs reach urine remains unclear. Here, we demonstrate that the glomerulus actively transcytoses circulating tumor-derived sEVs into urine. Using CRISPR guide RNA-tagged glioma sEVs and bioluminescent/fluorescent green-enhanced nano-lantern (GeNL)-tagged lung and pancreatic cancer sEVs, we tracked their journey from tumors to urine in multiple mouse models. In vivo and in vitro analyses revealed endocytic uptake and transcytotic release by glomerular cells, accompanied by changes in sEV size and surface composition. GeNL-tagged sEVs consistently showed higher signals in urine than plasma, indicating selective excretion. These findings redefine the glomerulus as a dynamic regulator of sEV processing and establish a mechanistic foundation for urinary liquid biopsy.
• Plasmon-Enhanced Photoluminescence of Interlayer Excitons Induced on WSe2/MoS2 Heterobilayers
  Keisuke Imaeda; Yusuke Takahashi; Shimba Ushikoshi; Takahiko Endo; Yasumitsu Miyata; Kosuke Nagashio; Sou Ryuzaki; Kosei Ueno
  The Journal of Physical Chemistry Letters, 17, 6, 1670, 1676, 12 Feb. 2026, [International Magazine]
  English, Scientific journal, Excitonic light emission from transition-metal dichalcogenides (TMDs) heterobilayers has attracted considerable attention as a promising platform for atomically thin light sources. However, their emission efficiency is limited by the momentum mismatch between the valleys of the constituent TMD monolayers, and hence improving the emission quantum yield is highly desirable for their practical implementation in light-emitting devices. Here, we achieve a 10-fold enhancement of momentum-indirect emission by resonantly coupling plasmonic nanostructures with the WSe2/MoS2 heterobilayer. We observe a pronounced acceleration of the radiative recombination process of interlayer excitons in the plasmon-heterobilayer coupled system, demonstrating that the emission enhancement originates from the plasmonic Purcell effect. Our findings provide valuable insight into the influence of the plasmonic Purcell effect on momentum-indirect radiative transitions in TMD heterobilayers and offer compelling evidence that plasmonic nanostructures can effectively promote such transitions, paving the way for the development of highly efficient light-emitting devices based on TMD heterobilayers.
• Gap-Controlled Plasmon Dephasing and Near-Field Confinement in Metal–Insulator–Metal Nanostructures
  Hiroki Takeuchi; Xiongjunyi Qian; Xiao-Tong Pan; Keisuke Imaeda; Sou Ryuzaki; Kosei Ueno
  The Journal of Physical Chemistry C, 11 Dec. 2025
  Scientific journal
• High-Q Plasmonic Nanocavities Enabled by Integration of Au Nanogap Dimers with a Distributed Bragg Reflector
  Keisuke Imaeda; Rin Miyazaki; Sou Ryuzaki; Kosei Ueno
  The Journal of Physical Chemistry C, 13 Mar. 2025
  Scientific journal
• Coherent acoustic vibrations of Au nanoblocks and their modulation by Al2O3 layer deposition
  Keisuke Imaeda; Yuto Shikama; Shimba Ushikoshi; Satoshi Sakai; Sou Ryuzaki; Kosei Ueno
  The Journal of Chemical Physics, 160, 14, 14 Apr. 2024, [International Magazine]
  English, Scientific journal, Coherent acoustic phonons induced in metallic nanostructures have attracted tremendous attention owing to their unique optomechanical characteristics. The frequency of the acoustic phonon vibration is highly sensitive to the material adsorption on metallic nanostructures and, therefore, the acoustic phonon offers a promising platform for ultrasensitive mass sensors. However, the physical origin of acoustic frequency modulation by material adsorption has been partially unexplored so far. In this study, we prepared Al2O3-deposited Au nanoblocks and measured their acoustic phonon frequencies using time-resolved pump-probe measurements. By precisely controlling the thickness of the Al2O3 layer, we systematically investigated the relation between the acoustic phonon frequency and the deposited Al2O3 amounts. The time-resolved measurements revealed that the acoustic breathing modes were predominantly excited in the Au nanoblocks, and their frequencies increased with the increment of the Al2O3 thickness. From the relationship between the acoustic phonon frequency and the Al2O3 thickness, we revealed that the acoustic phonon frequency modulation is attributed to the density change of the whole sample. Our results would provide fruitful information for developing quantitative mass sensing devices based on metallic nanostructures.
• Exploring Hybrid States and Their Ultrafast Dynamics in Exciton–Plasmon Strong Coupling Systems
  Hiroki Takeuchi; Keisuke Imaeda; Sou Ryuzaki; Kosei Ueno
  The Journal of Physical Chemistry C, 15 Feb. 2024
  Scientific journal
• Transient Nascent Adhesion at the Initial Stage of Cell Adhesion Visualized on a Plasmonic Metasurface
  Shi Ting Lee; Thasaneeya Kuboki; Satoru Kidoaki; Yukiko Aida; Sou Ryuzaki; Koichi Okamoto; Yusuke Arima; Kaoru Tamada
  Advanced NanoBiomed Research, 2100100, 2100100, Wiley, Jan. 2022
  Scientific journal
• Field effect control of translocation dynamics in surround-gate nanopores
  Makusu Tsutsui; Sou Ryuzaki; Kazumichi Yokota; Yuhui He; Takashi Washio; Kaoru Tamada; Tomoji Kawai
  Communications Materials, 2, 1, Dec. 2021
  English, Scientific journal
• Effect of chemically induced permittivity changes on the plasmonic properties of metal nanoparticles
  Noboru Saito; Sou Ryuzaki; Yuta Tsuji; Yutaka Noguchi; Rintaro Matsuda; Pangpang Wang; Daisuke Tanaka; Yusuke Arima; Koichi Okamoto; Kazunari Yoshizawa; Kaoru Tamada
  Communications Materials, 2, 1, Dec. 2021
  English, Scientific journal
• Rapid Discrimination of Extracellular Vesicles by Shape Distribution Analysis
  Sou Ryuzaki; Takao Yasui; Makusu Tsutsui; Kazumichi Yokota; Yuki Komoto; Piyawan Paisrisarn; Noritada Kaji; Daisuke Ito; Kaoru Tamada; Takahiro Ochiya; Masateru Taniguchi; Yoshinobu Baba; Tomoji Kawai
  Analytical Chemistry, 93, 18, 7037, 7044, 11 May 2021, [International Magazine]
  English, Scientific journal
• Layer Number-Dependent Enhanced Photoluminescence from a Quantum Dot Metamaterial Optical Resonator
  Haruka Takekuma; Junfu Leng; Kazutaka Tateishi; Yang Xu; Yinthai Chan; Sou Ryuzaki; Pangpang Wang; Koichi Okamoto; Kaoru Tamada
  ACS Applied Electronic Materials, 3, 1, 468, 475, 26 Jan. 2021
  English, Scientific journal
• High Axial and Lateral Resolutions on Self-Assembled Gold Nanoparticle Metasurfaces for Live-Cell Imaging
  Shihomi Masuda; Thasaneeya Kuboki; Satoru Kidoaki; Shi Ting Lee; Sou Ryuzaki; Koichi Okamoto; Yusuke Arima; Kaoru Tamada
  ACS Applied Nano Materials, 3, 11, 11135, 11142, American Chemical Society ({ACS}), 25 Nov. 2020
  Scientific journal
• Pore Structures for High-Throughput Nanopore Devices
  Sou Ryuzaki; Rintaro Matsuda; Masateru Taniguchi
  Micromachines, 11, 10, 893, 893, Sep. 2020, [International Magazine]
  English, Scientific journal
• Flexibly tunable surface plasmon resonance by strong mode coupling using a random metal nanohemisphere on mirror
  Okamoto, K.; Okura, K.; Wang, P.; Ryuzaki, S.; Tamada, K.
  Nanophotonics, 9, 10, 3409, 3418, 2020
  Scientific journal
• Finite-difference time-domain simulations of inverted cone-shaped plasmonic nanopore structures
  Matsuda, R.; Ryuzaki, S.; Okamoto, K.; Arima, Y.; Tsutsui, M.; Taniguchi, M.; Tamada, K.
  Journal of Applied Physics, 127, 24, 2020
  Scientific journal
• Tuning the Emission Colors of Self-Assembled Quantum Dot Monolayers via One-Step Heat Treatment for Display Applications
  Leng, J.; Xu, Y.; Chan, Y.; Wang, P.; Ryuzaki, S.; Okamoto, K.; Tamada, K.
  ACS Applied Nano Materials, 3, 4, 3214, 3222, American Chemical Society ({ACS}), 2020
  Scientific journal
• Comparison of the mechanical strength of a monolayer of silver nanoparticles both in the freestanding state and on a soft substrate
  Wang, P.; Ryuzaki, S.; Gao, L.; Shinohara, S.; Saito, N.; Okamoto, K.; Tamada, K.; Yamada, S.
  Journal of Applied Physics, 125, 13, 2019
  English, Scientific journal
• Micro-photoluminescence mapping of light emissions from aluminum-coated InGaN/GaN quantum wells
  Tateishi, K.; Wang, P.; Ryuzaki, S.; Funato, M.; Kawakami, Y.; Okamoto, K.; Tamada, K.
  Applied Physics Express, 12, 5, 2019
  English, Scientific journal
• How to make microscale pores on a self-assembled Ag nanoparticle monolayer
  Takekuma, H.; Tagomori, K.; Shinohara, S.; Masuda, S.; Xu, Y.; Chan, Y.; Wang, P.; Ryuzaki, S.; Okamoto, K.; Tamada, K.
  Colloids and Interface Science Communications, 30, 2019
  English, Scientific journal
• Comparison of LSPR-mediated enhanced fluorescence excited by S- and P-polarized light on a two-dimensionally assembled silver nanoparticle sheet
  Ishijima, A.; Wang, P.; Ryuzaki, S.; Okamoto, K.; Tamada, K.
  Applied Physics Letters, 113, 17, 2018
  Scientific journal
• Surface plasmon resonance effect of silver nanoparticles on the enhanced efficiency of inverted hybrid organic-inorganic solar cell
  Wulandari, P.; Handayani, Y.S.; Hidayat, R.; Wang, P.; Ryuzaki, S.; Okamoto, K.; Tamada, K.
  Journal of Nonlinear Optical Physics and Materials, 27, 2, 2018
  English, Scientific journal
• Durability improvements of two-dimensional metal nanoparticle sheets by molecular cross-linked structures between nanoparticles
  Saito, N.; Ryuzaki, S.; Wang, P.; Park, S.; Sakai, N.; Tatsuma, T.; Okamoto, K.; Tamada, K.
  Japanese Journal of Applied Physics, 57, 3, 2018
  English, Scientific journal
• Micro-photoluminescence mapping of surface plasmon enhanced light emissions from InGaN/GaN quantum wells
  Tateishi, K.; Wang, P.; Ryuzaki, S.; Funato, M.; Kawakami, Y.; Okamoto, K.; Tamada, K.
  Applied Physics Letters, 111, 17, 2017
  English, Scientific journal
• Rapid structural analysis of nanomaterials in aqueous solutions
  Ryuzaki, S.; Tsutsui, M.; He, Y.; Yokota, K.; Arima, A.; Morikawa, T.; Taniguchi, M.; Kawai, T.
  Nanotechnology, 28, 15, 155501, 155501, 2017, [International Magazine]
  English, Scientific journal
• Photoexcited carrier dynamics in organic solar cells
  Ryuzaki, S.; Onoe, J.
  Organic Solar Cells: Materials, Devices, Interfaces, and Modeling, 2017
  Scientific journal
• Graphene-Au nanoparticle based vertical heterostructures: A novel route towards high-ZT Thermoelectric devices
  Juang, Z.-Y.; Tseng, C.-C.; Shi, Y.; Hsieh, W.-P.; Ryuzaki, S.; Saito, N.; Hsiung, C.-E.; Chang, W.-H.; Hernandez, Y.; Han, Y.; Tamada, K.; Li, L.-J.
  Nano Energy, 38, 385, 391, 2017
  Scientific journal
• Large patternable metal nanoparticle sheets by photo/e-beam lithography
  Saito, N.; Wang, P.; Okamoto, K.; Ryuzaki, S.; Tamada, K.
  Nanotechnology, 28, 43, 435705, 435705, 2017, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• High-resolution imaging of a cell-attached nanointerface using a gold-nanoparticle two-dimensional sheet
  Masuda, S.; Yanase, Y.; Usukura, E.; Ryuzaki, S.; Wang, P.; Okamoto, K.; Kuboki, T.; Kidoaki, S.; Tamada, K.
  Scientific Reports, 7, 1, 3720, 3720, 2017, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Electrical trapping mechanism of single-microparticles in a pore sensor
  Arima, A.; Tsutsui, M.; He, Y.; Ryuzaki, S.; Taniguchi, M.
  AIP Advances, 6, 11, 2016
  English, Scientific journal
• Electromagnetically induced transparency of a plasmonic metamaterial light absorber based on multilayered metallic nanoparticle sheets
  Okamoto, K.; Tanaka, D.; Degawa, R.; Li, X.; Wang, P.; Ryuzaki, S.; Tamada, K.
  Scientific Reports, 6, 36165, 36165, 2016, [International Magazine]
  English, Scientific journal
• Silver nanoparticles with tunable work functions
  Wang, P.; Tanaka, D.; Ryuzaki, S.; Araki, S.; Okamoto, K.; Tamada, K.
  Applied Physics Letters, 107, 15, 2015
  English, Scientific journal
• Local charge transport properties of hydrazine reduced monolayer graphene oxide sheets prepared under pressure condition
  Ryuzaki, S.; Meyer, J.A.S.; Petersen, Sø.; Nørgaard, K.; Hassenkam, T.; Laursen, B.W.
  Applied Physics Letters, 105, 9, 2014
  English, Scientific journal
• Graphene/hexagonal boron nitride/graphene nanopore for electrical detection of single molecules
  He, Y.; Tsutsui, M.; Ryuzaki, S.; Yokota, K.; Taniguchi, M.; Kawai, T.
  NPG Asia Materials, 6, 6, 2014
  English, Scientific journal
• Anomaly in the electric resistivity of one-dimensional uneven peanut-shaped C60 polymer film at a low temperature
  Ryuzaki, S.; Onoe, J.
  Applied Physics Letters, 104, 11, 2014
  Scientific journal
• Basic aspects for improving the energy conversion efficiency of hetero-junction organic photovoltaic cells
  Sou Ryuzaki; Jun Onoe
  NANO REVIEWS & EXPERIMENTS, 4, 1, 2013, [International Magazine]
  English, Scientific journal
• High speed DNA denaturation using microheating devices
  Furuhashi, M.; Okamoto, Y.; Onoshima, D.; Ohshiro, T.; Ryuzaki, S.; Yokota, K.; Tsutsui, M.; Taniguchi, M.; Nakatani, K.; Baba, Y.; Kawai, T.
  Applied Physics Letters, 103, 2, 2013
  English, Scientific journal
• In situ nondestructive impedance spectroscopic study of nanostructured heterojunction organic photovoltaic cells
  Ryuzaki, S.; Onoe, J.
  Japanese Journal of Applied Physics, 52, 6 PART 2, 2013
  English, Scientific journal
• Trapping and identifying single-nanoparticles using a low-aspect-ratio nanopore
  Tsutsui, M.; Maeda, Y.; He, Y.; Hongo, S.; Ryuzaki, S.; Kawano, S.; Kawai, T.; Taniguchi, M.
  Applied Physics Letters, 103, 1, 2013
  English, Scientific journal
• Electron transport properties of air-exposed one-dimensional uneven peanut-shaped C60 polymer films
  Ryuzaki, S.; Nishiyama, M.; Onoe, J.
  Diamond and Related Materials, 33, 12, 15, 2013
  English, Scientific journal
• Photo-generated carrier dynamics in the vicinity of the donor/acceptor interface of organic solar cells
  Ryuzaki, S.; Onoe, J.
  IEEJ Transactions on Electronics, Information and Systems, 132, 8, 1, 8, 2012
  English, Scientific journal
• Influence of charge accumulation of photogenerated carriers in the vicinity of donor/acceptor interface on the open-circuit voltage of zinc-porphyrin/ C60 heterojunction organic photovoltaic cells
  Ryuzaki, S.; Onoe, J.
  Journal of Physics D: Applied Physics, 44, 26, 2011
  English, Scientific journal
• Effects of inter-molecular charge-transfer excitons on the external quantum efficiency of zinc-porphyrin/C60 heterojunction photovoltaic cells
  Ryuzaki, S.; Kai, T.; Toda, Y.; Adachi, S.; Onoe, J.
  Journal of Physics D: Applied Physics, 44, 14, 2011
  English, Scientific journal
• X-ray diffraction and infrared multiple-angle incidence resolution spectroscopic studies on the crystal structure and molecular orientation of zinc-porphyrin thin films on a SiO2/Si substrate
  Ryuzaki, S.; Hasegawa, T.; Onoe, J.
  Journal of Applied Physics, 105, 11, 2009
  Scientific journal
• X-ray diffraction and scanning electron microscopic studies on the crystal structure and surface/interface morphology of zinc-octaethylporphyrin films on an indium tin oxide substrate spin coated with 3,4-polyethylenedioxythiophene: polystyrenesulfonate
  Ryuzaki, S.; Onoe, J.
  Journal of Applied Physics, 106, 2, 2009
  Scientific journal
• The crystallinity and surface morphology of zinc octaethylporphyrin thin films on an indium-tin-oxide substrate
  Ryuzaki, S.; Onoe, J.
  Journal of Applied Physics, 103, 3, 2008
  Scientific journal
• Femtosecond carrier dynamics in electron-beam-irradiated C60 film
  Toda, Y.; Ryuzaki, S.; Onoe, J.
  Applied Physics Letters, 92, 9, 2008
  Scientific journal
• In situ X-ray photoelectron spectroscopic study of metalloporphyrin- fullerene alternative-deposited thin films
  Ryuzaki, S.; Ishii, T.; Onoe, J.
  Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers, 46, 8 A, 5363, 5366, INSTITUTE OF PURE AND APPLIED PHYSICS, 2007
  English, Scientific journal

• EVs : 細胞外小胞の生物学 : エクソソームをはじめとする多様な小胞の生理・病理の理解と新しい解析法
  中野, 明彦; 吉森, 保; 華山, 力成
  羊土社, Dec. 2021, 9784758103992, 207p, Japanese, [Contributor]
• 化学75-5月号「注目の論文：エクソソームの表面タンパク質を見分ける」
  龍崎奏
  May 2020, [Contributor]
• Organic Solar Cells : Materials, Devices, Interfaces, and Modeling
  Sou Ryuzaki
  Dec. 2017, [Contributor]

• バイオマーカーとしての細胞外小胞
  龍崎奏
  1. ⾰新的エネルギー・物質変換⽅法に関する光・量⼦ビーム応⽤技術調査専⾨委員会, 01 Mar. 2026
  [Invited]
• 1粒子解析技術を用いたバイオデバイスの実装
  龍崎奏
  大学発新産業創出基金事業 プログラム間連携戦略会議, 12 Dec. 2025
  [Invited]
• ナノポアデバイスを⽤いた細胞外⼩胞解析
  龍崎奏
  iGCOREセミナー, 30 Jul. 2025
  [Invited]
• ナノポアデバイスの最前線
  龍崎奏
  第7回名古屋大学エネルギー理工学セミナー, 26 Jun. 2025
  [Invited]
• 電気泳動とナノポアデバイス
  第75回日本電気泳動学会シンポジウム, 12 May 2025
  [Invited]
• 電気泳動とラマン分光法
  龍崎奏
  第44回キャピラリー電気泳動シンポジウム, 10 Oct. 2024
  [Invited]
• ナノテクノロジーによる未来医療のアプローチ
  龍崎奏
  第71回応用物理学会春季学術講演会, 23 Mar. 2024
  [Invited]
• 分子軌道論的プラズモニクス
  龍崎奏
  第4回次世代プラズモニック化学への挑戦, 14 Mar. 2024
• 1粒子解析技術の社会実装
  龍崎奏
  北海道・札幌Life Science INDEX vol.4, 11 Mar. 2024
  [Invited]
• Nanopore Devices for Single Nanoparticles
  Sou Ryuzaki
  KJF-ICOMEP 2023, 02 Sep. 2023
  [Invited]
• Rapid Raman spectroscopy for extracellular vesicles.
  Sou Ryuzaki
  2023 KBCS-Hokkaido University Joint Symposium on BioChip Technology,, 28 Jun. 2023
  [Invited]
• Fabrication of nanopore devices for Exosomes
  Sou Ryuzaki
  35th International Microprocesses and Nanotechnology Conference, 08 Nov. 2022, English, Invited oral presentation
  08 Nov. 2022 - 11 Nov. 2022, [Invited]
• ナノポアデバイスによるエクソソーム1粒子解析技術
  龍崎奏
  日本細胞外小胞学会, 24 Oct. 2022
  [Invited]

• 無機化学Ⅲ, 2024年, 学士課程, 理学部

• 2022 - Present
  日本化学会
• 2021 - Present
  日本分析化学会
• 2021 - Present
  American Chemical Society
• 2005 - Present
  DV-Xα研究協会
• 2005 - Present
  ナノ学会
• 2005 - Present
  応用物理学会

• A Study of Viral Material Engineering
  Grants-in-Aid for Scientific Research
  01 Apr. 2026 - 31 Mar. 2030
  谷口 正輝; 龍崎 奏
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (S), The University of Osaka, 25K24711
• Development of a novel diagnostic method for lung cancer based on extracellular vesicle (EV) molecular profiling
  Grants-in-Aid for Scientific Research
  01 Apr. 2026 - 31 Mar. 2029
  加藤 達哉; 畑中 佳奈子; 畑中 豊; 新垣 雅人; 龍崎 奏
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 26K10227
• プラズモニックナノ構造と機械学習を用いたmiRNA分布識別法の開発
  科学研究費助成事業
  01 Apr. 2025 - 31 Mar. 2028
  龍崎 奏
  日本学術振興会, 基盤研究(C), 北海道大学, 25K08449
• 1粒子解析技術を用いたバイオデバイスの実装
  大学発新産業創出基金事業（北海道大学）
  Apr. 2025 - Mar. 2028
  龍崎奏
  科学技術振興機構, Principal investigator
• 無細胞合成による脂質ナノ粒子の高速改変技術の研究開発
  医薬品開発の進展に資する革新的技術の創出研究【若手育成枠】
  Apr. 2025 - Mar. 2028
  日本医療研究開発機構, Coinvestigator
• Development of a single particle analysis platform and a comprehensive understanding of the diversity of bacterial membrane vesicles
  Grants-in-Aid for Scientific Research
  01 Apr. 2024 - 31 Mar. 2027
  田代 陽介; 龍崎 奏; 横山 文秋
  膜小胞は多様な生物学的機能を有するナノ粒子であり、病原因子の運搬や細胞間コミュニケーション、免疫応答の制御など、宿主との相互作用において重要な役割を担っている。しかし、これまでの研究は主に集団平均に基づいた解析が中心であり、個々の膜小胞が示す構造的・機能的な不均一性には十分に着目されてこなかった。そこで本研究では、「クローナルな細菌からいかにして多様な膜小胞が放出されるのか」という本質的な問いに対し、一微粒子ごとの組成・特性を解析する技術と、一細胞単位で放出された膜小胞を評価する技術を統合し、その解明を試みた。
  
  
  初年度は、膜小胞の多様性の理解に向けて、大腸菌由来膜小胞の形成機構に関与する遺伝子変異株を用いた比較解析を実施した。特に、膜小胞産生量の高い変異株に着目し、透過型電子顕微鏡による形態観察を行った結果、複数の株において多重膜構造を有する膜小胞が確認された。さらに、各変異株の細胞壁を抽出・観察したところ、多重膜小胞を形成する株では細胞壁構造に微細な孔（ポア）が形成されていた。これらの結果から、細胞壁のリモデリング機能の低下が膜小胞の構造的多様性の出現に関与している可能性が示された。
  
  
  一方で、一細菌レベルの膜小胞産生を評価するための観察技術の構築も進めた。具体的には、個々の細菌を捕捉するセルトラップ構造と、放出された膜小胞を捉えるナノ高さ構造を備えたナノ・マイクロ流体デバイスを設計・作製した。作製したデバイスに細菌を導入したところ、細菌が安定的に捕捉され、膜小胞の放出挙動をリアルタイムで計測可能であった。今後は、当該デバイスを改良し、膜小胞産生の個体差を統計的に解析するシステムを構築する予定である。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Shizuoka University, 24K01666
• Biosensor based on surface molecular information of extracellular vesicles
  Grants-in-Aid for Scientific Research
  01 Apr. 2022 - 31 Mar. 2025
  Ryuzaki Sou
  In this study, "single-particle surface molecular analysis technology," originally developed by the applicant, was employed to measure the surface molecules of various extracellular vesicles (EVs) secreted from different cancer cell lines, as well as EVs isolated from the plasma of cancer patients. Classification and surface molecular profiling of individual EVs were performed. As a result, classification analysis using optimized machine learning achieved an identification accuracy exceeding 95%. Interestingly, EVs derived from anatomically or functionally related organs exhibited relatively high similarity in their surface molecular profiles. Future expansion of sample size and clinical study scale is expected to facilitate the development of a novel cancer diagnostic method based on EV surface molecular information.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 23K23195
• Biosensor based on surface molecular information of extracellular vesicles
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
  01 Apr. 2022 - 31 Mar. 2025
  龍崎 奏; 馬場 英司
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 22H01927
• Metal multi-nanopore structures for quantum dot lasing
  Grants-in-Aid for Scientific Research
  01 Apr. 2019 - 31 Mar. 2022
  Ryuzaki Sou
  A novel laser has been developed by metal multi-nanopore structure with a diameter of ca.100 nm filled with a solution in which quantum dots (QDs) are dispersed. The Fabry-Perot type lasing is caused by plasmonic resonances between the emission from QDs and the metal multi-nanopore structure. In this study, the following results have been mainly achieved. (1) Development of a method to control the emission characteristics of quantum dots after synthesis, (2) Fabrication and characterization of plasmonic nanopores, (3) Revealing the correlation between electronic state at the metal-organic interface and plasmon resonance properties, (4) Fabry-Perot type lasing by the metal multi-nanopore structure.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kyushu University, 19K05234
• Exosome analysis device for cancer early diagnosis
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
  01 Apr. 2016 - 31 Mar. 2020
  Baba Yoshinobu
  Exosomes are extracellular vesicles and play an important role for cancer tumorigenesis, cancer progression, and cancer metastasis. And, exosomes have more information than conventional blood biomarkers. Recently, researchers expected exosomes as the next-generation cancer diagnosis biomarkers. In this research, we proposed a device to demonstrate rapid and precise analysis of cancer specific exosomes using nanospace unique features. And furthermore, we had a goal to aim for cancer diagnosis system, which could achieve higher speed and more accurate diagnosis than conventional systems.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Nagoya University, 16H02091
• 形状と組成情報に基づく1粒子解析技術の開発
  戦略的な研究開発の推進 戦略的創造研究推進事業 さきがけ
  2017 - 2020
  龍崎 奏
  本研究では、液中に浮遊している微粒子の「形状情報」と「組成情報」を同時に計測する革新的1粒子解析技術の開発をねらいとしています。生体微粒子において、「形状」と「組成」の相関性を解明することは、その微粒子の機能解明へと繋がります。本研究では、がん転移の指向性などに関わっているとされているエクソソームの「形状」と「組成」の相関性を明らかにし、構造的な観点からエクソソームの機能解析を目指します。
  科学技術振興機構, 九州大学
• Nanopore devices for structural analysis of nanobio materials
  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)
  01 Apr. 2015 - 31 Mar. 2018
  Ryuzaki sou; TANIGUCHI Masateru
  Rapid structural analysis of nanoscale matter in a liquid environment represents innovative technologies that reveal the identities and functions of biologically important molecules. However, there is currently no method with high spatio-temporal resolution that can scan individual particles in solutions to gain structural information. Here we report the development of a nanopore platform realizing quantitative structural analysis for suspended nanomaterials in solutions. We used a low thickness-to-diameter aspect ratio pore architecture for achieving cross sectional areas of analyte (i.e. tomograms). Combining this with multiphysics simulation methods to translate ionic current data into tomograms, we demonstrated rapid structural analysis of many kind of single vesicles and EVs. The present results indicate this structural analysis is very powerful tool to identify nano-bioparticles and have a potential as novel nanobio sensors from the view point of particle shapes.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (A), Kyushu University, 15H05417
• Complex 3D nanometamaterials composed of self-assembled metal nanoparticles
  Grants-in-Aid for Scientific Research
  01 Apr. 2014 - 31 Mar. 2018
  Tamada Kaoru; OKAMOTO Koichi; RYUZAKI Sou; WANG Pangpang; PARK Cheomin; WULANDARI Pristuti; LI Lain-Jong; CRAIG S. J. Vincent; CHAN Yin Thai; YANG Xu
  This study aimed at multidimensional self-assembly of metallic nanoparticles, and theoretical and experimental elucidation of novel optical phenomena developed in this study, and development of novel nano-optical devices using these phenomena. The main scientific achievement is to reveal the origin of color change observed on multidimensional self-assembled metal nanoparticle sheets on a metal substrate, as "electromagnetically induced transparency (EIT)". The main achievements in application are
  development of colorimetric sensors by use of EIT and super resolution imaging of cell attached nano interface. These our original studies disseminate the fundamental field of plasmonic and nanometamaterials to the world.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Kyushu University, 26246005
• Nanopore devices for a structural analysis of single molecules
  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
  01 Apr. 2013 - 31 Mar. 2015
  RYUZAKI Sou
  Nanopore devices consisting of a surround gating electrode causing a decrease in speed of nanomaterials passing through the nanopore have been fabricated in order to analyze structures of the materials. The gating voltage via a gating electrode resulted in 240 times slower speed of nanoparticles passing through a nanopore than that without the gating voltage, and DNA also showed 10 times slower speed under the gating voltage. In addition, the shapes and structures of these materials passing through a nanopore were quantitatively revealed by analysing changes in ionic current due to the material translation.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Kyushu University, 25790029

• 微粒子試料のスペクトルデータの生成方法、微粒子の解析方法、微粒子の判別方法、がん細胞由来のエクソソームの有無の判定方法、微粒子のスペクトル計測用基板、微粒子のスペクトル計測用デバイスおよび微粒子のスペクトル計測用装置
  Patent right, 龍▲崎▼ 奏; 松田 倫太郎; 谷口 正輝; 小本 祐貴, 国立大学法人北海道大学, 国立大学法人大阪大学
  JP2022042861, 18 Nov. 2022
  特許第7759631号
  202503019688283704
• 情報取得方法、判定方法、および情報取得装置
  Patent right, 龍崎 奏; 上野 貢生; 今枝 佳祐; 加藤 朗, 国立大学法人北海道大学
  特願2023-141223, 31 Aug. 2023
  特開2025-034695, 13 Mar. 2025
  202503010247740533
• 積層体、積層体の製造方法および黒体フィルム
  Patent right, 龍▲崎▼ 奏; 斎藤 昴, 国立大学法人九州大学
  特願2020-170338, 08 Oct. 2020
  特開2022-062373, 20 Apr. 2022
  202203012159416654
• 撮像装置、撮像装置の制御方法、および制御プログラム
  Patent right, 谷口 正輝; 龍▲崎▼ 奏, 国立大学法人大阪大学
  特願2020-155668, 16 Sep. 2020
  特開2022-049450, 29 Mar. 2022
  202203001933472226
• 癌識別方法
  Patent right, 谷口 正輝; 筒井 真楠; 川合 知二; 馬場 嘉信; 安井 隆雄; 落谷 孝広; 龍崎 奏; 玉田 薫, 国立大学法人大阪大学
  特願2020-136366, 12 Aug. 2020
  特開2020-201272, 17 Dec. 2020
  202003010918372805
• エクソソームの形状分布の解析装置、がん検査装置、エクソソームの形状分布の解析方法、及びがん検査方法
  Patent right, 谷口 正輝; 筒井 真楠; 川合 知二; 馬場 嘉信; 安井 隆雄; 落谷 孝広; 龍崎 奏; 玉田 薫, 国立大学法人大阪大学, 国立研究開発法人国立がん研究センター
  特願2016-038204, 29 Feb. 2016
  特開2017-156168, 07 Sep. 2017
  特許第6762494号
  202003009985065439
• 試料作製装置および試料作製方法
  Patent right, 川合 知二; 谷口 正輝; 龍崎 奏; 橘田 和美; 高畠 令王奈; 真野 潤一; 中江 裕樹; 布藤 聡; 吉井 淳治, 国立大学法人大阪大学, 国立研究開発法人農業・食品産業技術総合研究機構, 株式会社ファスマック
  特願2015-072796, 31 Mar. 2015
  特開2015-198652, 12 Nov. 2015
  特許第6610858号
  201903010405138482
• 物質の移動速度の制御方法および制御装置
  Patent right, 川合 知二; 龍▲崎▼ 奏; 谷口 正輝, クオンタムバイオシステムズ株式会社
  特願2012-286115, 27 Dec. 2012
  特開2014-126554, 07 Jul. 2014
  特許第6282036号
  201803017148792211
• エクソソームの形状分布の解析装置、がん検査装置、エクソソームの形状分布の解析方法、及びがん検査方法
  Patent right, 谷口 正輝; 筒井 真楠; 川合 知二; 馬場 嘉信; 安井 隆雄; 落谷 孝広; 龍崎 奏; 玉田 薫, 国立大学法人大阪大学, 国立大学法人名古屋大学, 国立研究開発法人国立がん研究センター
  特願2016-038204, 29 Feb. 2016
  特開2017-156168, 07 Sep. 2017
  201703011238255104
• 一粒子解析装置および解析方法
  Patent right, 本郷 禎人; 川合 知二; 筒井 真楠; 谷口 正輝; 龍▲崎▼ 奏, 株式会社東芝, 国立大学法人大阪大学
  特願2014-504909, 11 Mar. 2013
  特許第5866652号
  201603010160634495
• 試料作製装置および試料作製方法
  Patent right, 川合 知二; 谷口 正輝; 龍崎 奏; 橘田 和美; 高畠 令王奈; 真野 潤一; 中江 裕樹; 布藤 聡; 吉井 淳治, 国立大学法人大阪大学, 国立研究開発法人農業・食品産業技術総合研究機構, 特定非営利活動法人バイオチップコンソーシアム
  特願2015-072796, 31 Mar. 2015
  特開2015-198652, 12 Nov. 2015
  201503011303071445
• 物質の移動速度の制御方法および制御装置
  Patent right, 川合 知二; 龍▲崎▼ 奏; 谷口 正輝, 国立大学法人大阪大学
  特願2012-286115, 27 Dec. 2012
  特開2014-126554, 07 Jul. 2014
  201403099412151986
• 一粒子解析装置および解析方法
  Patent right, 本郷 禎人; 川合 知二; 筒井 真楠; 谷口 正輝; 龍▲崎▼ 奏, 株式会社東芝, 国立大学法人大阪大学
  JP2013056690, 11 Mar. 2013
  WO2013-137209, 19 Sep. 2013
  201503005282402764

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  24 Sep. 2025 - 26 Sep. 2025
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  23 Sep. 2025 - 26 Sep. 2025
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  30 Aug. 2023 - 02 Sep. 2023
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