Researcher basic information

• Ph.D. (Dentistry), Niigata University, Sep. 2015
• Master of Public Health, The University of Tokyo, Mar. 2022

• https://researchmap.jp/misuzu.sato?lang=en

• https://orcid.org/0000-0002-4752-8852
• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202301009422887739

• 40772504

• https://orcid.org/0000-0002-4752-8852

• 202301009422887739

• レセプトデータベース
• 歯科
• 臨床疫学
• 疫学

• Life Science, Social dentistry, 疫学 臨床疫学 レセプトデータベース

• Bachelor's degree program, School of Dental Medicine
• Doctoral (PhD) degree program, Graduate school of Dental Medicine

Research activity information

• Mar. 2021, 東京大学, 総長大賞
  コロナ禍における保健所支援活動
  保健所コロナ禍対策支援有志チーム
• May 2019, 第68回 日本口腔衛生学会・総会, 論文奨励賞
  地域在住高齢者における現在歯数および義歯の使用状況・主観的評価とフレイルとの関連についての横断研究
  佐藤美寿々;岩﨑正則;皆川久美子;小川祐司;山賀孝之;葭原明弘;宮﨑秀夫
• Jun. 2015, 第26回甲信越北陸口腔保健研究会総会・学術大会, 発表奨励賞
  地域在住高齢者におけるフレイル（虚弱）と現在歯数との関連についての横断研究
  佐藤美寿々,岩崎正則,葭原明弘,宮崎秀夫

• Multiple Tobacco Product Use and Dental Pain: A Cross-sectional Study
  T. Yamamoto; H. Abbas; M. Sato; M. Iwasaki; T. Tabuchi
  JDR Clinical & Translational Research, 06 Aug. 2026
  Scientific journal
• Relationship between end of life of older adults in long-term care facilities and full-time dental hygienist service: A 2-year multicenter study.
  Nami Machi; Yutaka Watanabe; Kazuhito Miura; Kimiya Ozaki; Misuzu Sato; Masanori Iwasaki; Maki Shirobe; Hirohiko Hirano; Yuki Ohara; Yoshihiro Kugimiya; Masataka Itoda; Takeshi Kikutani; Midori Tsuneishi; Yuko Kuboyama; Shinsuke Mizutani; Shigekazu Komoto; Yutaka Yamazaki
  Geriatrics & gerontology international, 16 Sep. 2025, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, AIM: This study aimed to examine the relationship between dental hygienist work arrangements in long-term care insurance facilities and the likelihood of residents dying in the facility (in-facility death) rather than in a hospital (hospital death). METHODS: In this 2-year, multicenter, longitudinal study, a baseline survey of 958 residents from 30 long-term care insurance facilities was conducted in 2019, followed by a 2-year outcome survey. The survey items comprised end-of-survey outcomes (death, inpatient discharge), length of stay, and resident preferences for end-of-life care in the facility. A modified Poisson analysis was conducted, with the dependent variable end of life in the facility coded as 1 (possible) or 0 (not possible) and whether the facility had a full-time hygienist representing the primary explanatory variable. RESULTS: Of the 958 residents (202 men and 742 women; mean age: 86.3 ± 8.1 years) included in the study, 464 were in the facility discharge group, and of these 142 (37.3%) died in the hospital and 239 (62.7%) died in the facility. Having access to a full-time dental hygienist (risk ratio [RR]: 1.23, 95% confidence interval [CI]: 1.03-1.46) and a preference for end of life in the facility (RR: 1.48, 95% CI: 1.23-1.79) were significantly associated with the end of life in the facility. CONCLUSIONS: The presence of a full-time dental hygienist in long-term care insurance facilities was associated with end of life in the facility for older adult residents requiring long-term care. Geriatr Gerontol Int 2025; ••: ••-••.
• Differences in health care expenditure due to the comorbidity status of periodontal disease and diabetes mellitus
  Anna Kinugawa; Kenji Takeuchi; Yudai Tamada; Taro Kusama; Misuzu Sato; Megumi Maeda; Fumiko Murata; Ken Osaka; Haruhisa Fukuda
  Journal of Periodontology, 96, 7, 760, 768, Jul. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: To investigate the differences in health care expenditure (HCE) due to the comorbidity status of periodontal disease (PD) and diabetes mellitus (DM). METHODS: This cohort study used health care claims and oral health screening data to identify participants with PD or DM and followed them for 1 year to assess their HCE. PD and DM were determined based on PD screening and medical claims data, respectively. The study participants were divided into four groups: participants without PD and DM (PD-/DM-), participants with PD and without DM (PD+/DM-), participants without PD and with DM (PD-/DM+), and participants with PD and DM (PD+/DM+). Covariates included age, sex, smoking status, and Charlson Comorbidity Index (CCI) score. A generalized linear model (GLM) with a gamma distribution and log link function was used to examine the association between comorbidity and annual HCE, and a two-part model was used to assess the differences in annual HCE. RESULTS: In total, 790 participants (mean age: 63.1, 30.3% male) were included. Compared with the PD-/DM- group, the relative cost ratio (RCR) for the PD+/DM+, PD-/DM+, PD+/DM- groups were 1.31 (95% confidence interval [CI]: 1.06-1.62), 1.27 (95% CI: 0.99-1.64), 1.01 (95% CI: 0.89-1.14) times higher, respectively. The adjusted mean annual HCE for the PD+/DM+, PD-/DM+, PD+/DM- groups were \59,328 (95% CI: 14,171-104,484), \50,228 (95% CI: -15,801-116,256), \-2,162 (95% CI: -24,598-20,274) higher than the PD-/DM- group, respectively. CONCLUSION: This study provides a significant contribution of PD to the increase in HCE, particularly in individuals with DM. PLAIN LANGUAGE SUMMARY: The association between periodontal disease (PD) and diabetes mellitus (DM) has commonly been described in previous literature, but the health expenditure incurred when PD and DM coexist is not clear. This study investigates the differences in health care expenditure (HCE) due to the comorbidity status of PD and DM. HCE is calculated from medical, dental, and pharmacy-dispensing expenditures from the claims data. PD was defined by periodontal pocket scores, and DM was determined based on medical records. Study participants were divided into four groups based on whether they had PD, DM, both, or neither. The results showed that people with both PD and DM had higher HCE compared with those without PD and DM. These findings may suggest the importance of cooperation between medical and dental professionals in the treatment of DM in terms of HCE.
• Association Between Undernutrition and the Number of Molar Occlusions in Older Persons Requiring Care in Long-Term Care Insurance Facilities
  Koji Takahashi; Yutaka Watanabe; Takuma Okumura; Yasushi Tamada; Misuzu Sato; Masanori Iwasaki; Maki Shirobe; Hirohiko Hirano; Yoshihiro Kugimiya; Masako Kishima; Kayoko Ito; Yasuyuki Iwasa; Yoshihiko Watanabe; Shinsuke Mizutani; Kazuharu Nakagawa; Shigekazu Komoto; Yutaka Yamazaki
  Nutrients, 17, 4, 630, 630, MDPI AG, 10 Feb. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Background/Objectives: Undernutrition increases the mortality risk in older persons requiring long-term care; further, it is associated with oral functions such as swallowing and chewing. Moreover, occlusion affects oral function and is crucially involved in nutritional intake. The present study aimed to examine the association between the number of molar occlusions and undernutrition according to body mass index (BMI) in older persons requiring long-term care. Methods: Japanese older persons requiring long-term care were categorized based on BMI (<20 kg/m2 vs. 20 kg/m2). We examined the association between undernutrition and the number of molar occlusions (one in each of the left and right premolars and molars, for a total of four). Results: Among 893 included participants, 440 (49.3%) had BMI < 20 kg/m2 and 453 (50.7%) had BMI > 20 kg/m2. Binomial logistic regression analysis revealed that BMI < 20 kg/m2 was significantly associated with increased number of molar occlusions (odds ratio: 0.52–0.70, 95% CI: 0.28–1.00). This indicated that a decrease in the number of molar occlusions was associated with malnutrition as determined through BMI in older persons requiring long-term care and residing in long-term care insurance facilities in Japan. Conclusions: Our findings suggest that maintaining occlusal support may help maintain nutritional status in older persons requiring long-term care.
• Impact of sending vouchers for a community-based oral screening program on dental service usage promotion among adults: a difference-in-difference analysis.
  Miho Ishimaru; Naoaki Kuroda; Sachiko Ono; Misuzu Sato; Jun Komiyama; Jun Aida; Nanako Tamiya
  BMC health services research, 24, 1, 1651, 1651, 26 Dec. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Community- and evidence-based approaches are essential for improving dental public health. We evaluated the effectiveness of sending vouchers in a community-based oral screening program to encourage dental visits and improve oral health among adults. METHODS: We analyzed the data from April 2014 to March 2019 obtained from administrative claims and screening program databases in Tsukuba City, Japan. This longitudinal observational study utilized the difference-in-difference approach to evaluate the impact of the screening program on dental service use. The exposure group, which comprised residents aged 30, 40, 50, 60, and 70 years who were eligible for the screening program and had received dental check-up vouchers, was compared with an age-matched control group, which comprised individuals aged ± 2 years. Dental service use was evaluated in terms of (1) whether monthly dental visits occurred, (2) the number of dental visits per person, and (3) the total monthly dental expenditure. RESULTS: Data were obtained from 43,438 residents (14,392 and 29,046 in the exposure and control groups, respectively). The program positively affected the likelihood of attending a dental visit (adjusted risk ratio, 1.04; 95% confidence interval [CI], 1.00-1.07) and the overall monthly expenditure on dental services (adjusted mean ratio, 1.03; 95% CI, 1.03-1.03). CONCLUSIONS: The oral screening program slightly increased dental service use among adults in Japan. The findings enable evidence-based policy-making on the improvement of the population-level oral health status.
• Reply to Letter to the Editor: Effect of periodontal therapy on glycaemic control in type 2 diabetes.
  Misuzu Sato; Sachiko Ono; Hideo Yasunaga
  Journal of clinical periodontology, 51, 9, 1255, 1255, 30 May 2024, [Peer-reviewed], [International Magazine]
  English
• Effect of periodontal therapy on glycaemic control in type 2 diabetes.
  Misuzu Sato; Sachiko Ono; Hayato Yamana; Akira Okada; Miho Ishimaru; Yosuke Ono; Masanori Iwasaki; Jun Aida; Hideo Yasunaga
  Journal of clinical periodontology, 51, 4, 380, 389, 03 Jan. 2024, [International Magazine]
  English, Scientific journal, AIM: This study aimed to elucidate the impact of periodontal therapy on glycaemic control in individuals with type 2 diabetes and various baseline blood glucose levels using a large-scale claims database from Japan. MATERIALS AND METHODS: Using the JMDC Claims Database, we identified individuals with type 2 diabetes who underwent health check-ups in the fiscal years 2018 or 2019 and were followed up until the next year's health check-up. We conducted a weighted cohort analysis using stabilized inverse probability weights for treatment and censoring to estimate the effect of periodontal therapy on changes in haemoglobin A1c levels within a year. Analysis was done for different baseline haemoglobin A1c categories: 6.5%-6.9%, 7.0%-7.9% and ≥8.0%. RESULTS: Of the 4279 insured persons included in the study, 957 received periodontal therapy. Overall, there was a tendency towards improved glycaemic control among those who received periodontal therapy. Participants with baseline haemoglobin A1c levels of 7.0%-7.9% who received periodontal therapy exhibited significantly better glycaemic control compared with those without dental visits (difference; -0.094 [95% confidence interval: -0.181 to -0.007]). CONCLUSIONS: Periodontal therapy may improve glycaemic control in individuals with diabetes, especially in those with haemoglobin A1c levels ≥7.0%.
• Dietary inflammatory index and number of functional teeth in middle-aged and older Japanese adults: A cross-sectional study using national survey data
  Masanori Iwasaki; Misuzu Sato; Dairo Takahashi; Takafumi Yamamoto
  Journal of Prosthodontic Research, 68, 4, 643, 649, Japan Prosthodontic Society, 2024, [Domestic magazines]
  English, Scientific journal, PURPOSE: To determine whether the number of functional teeth, including the remaining natural teeth and prosthetically restored missing teeth, is associated with the dietary inflammatory index (DII), a quantitative measure of the inflammatory potential of the overall diet, in middle-aged and older Japanese adults. METHODS: National survey data from a non-institutionalized Japanese population aged ≥45 years was analyzed. Multivariable linear regression analyses were performed to assess the association between the DII score, which was calculated based on dietary records, and the number of functional teeth, which was determined during dental examination. All regression analyses were stratified according to the age groups 45-64, 65-74, and ≥75 years. The association between functional tooth units (FTUs) and the DII was assessed using sensitivity analysis. RESULTS: In total, 2407 individuals (1053 men and 1354 women; mean age = 66.7 years) were included. Multivariable analysis revealed that the number of functional teeth was significantly inversely associated with the DII score among participants aged ≥75 years (regression coefficient per increase of one in the number of functional teeth = -0.050; 95% confidence interval = -0.089 to -0.010). The number of functional teeth was not associated with the DII score in younger age categories (i.e., those aged 45-74 years). As in the primary analysis, the number of FTUs was significantly inversely associated with the DII score only in the group aged ≥75 years. CONCLUSIONS: A greater number of functional teeth was associated with a lower DII (i.e., diet with greater anti-inflammatory potential) in Japanese adults aged ≥75 years.
• Studies of Health Insurance Claims Data in Japan: A Scoping Review
  Maiko Suto; Takehiro Sugiyama; Kenjiro Imai; Takashi Furuno; Mariko Hosozawa; Yuichi Ichinose; Noriko Ihana-Sugiyama; Tomoko Kodama; Ryuji Koizumi; Yuko Shimizu-Motohashi; Shunsuke Murata; Yayoi Nakamura; Mariko Niino; Misuzu Sato; Reina Taguchi; Misa Takegami; Motoko Tanaka; Kota Tsutsumimoto; Kentaro Usuda; Kenji Takehara; Hiroyasu Iso
  JMA Journal, 6, 3, 233, 245, Japan Medical Association, Jul. 2023, [Peer-reviewed]
  Scientific journal
• Impact of the national action plan for antimicrobial resistance on antibiotic use for mastitis using a Japanese nationwide database
  Takaaki Konishi; Michimasa Fujiogi; Misuzu Sato; Nobuaki Michihata; Hiroki Matsui; Kotoe Nishioka; Masahiko Tanabe; Yasuyuki Seto; Hideo Yasunaga
  BREAST CARE, 18, 2, 122, 129, Jan. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Amoxicillin vs third‐generation cephalosporin for infection prophylaxis after third molar extraction
  Misuzu Sato; Hayato Yamana; Sachiko Ono; Miho Ishimaru; Hiroki Matsui; Hideo Yasunaga
  Oral Diseases, 30, 2, 660, 668, 21 Nov. 2022, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, OBJECTIVES: Although amoxicillin is the first-line prophylactic drug for impacted mandibular third molar extraction, third-generation cephalosporins are widely prescribed in Japan. The lack of real-world evidence may be one reason for this inappropriate use. We evaluated differences in the incidence of surgical site infection between amoxicillin and third-generation cephalosporins for impacted mandibular third molar extraction. METHODS: Using the JMDC Claims Database, we identified dental visits with fully or horizontally impacted mandibular third molar extraction from April 2015 to March 2020. One-to-one propensity-score matching was conducted between amoxicillin and third-generation cephalosporin groups. The incidence of surgical site infection following extraction was compared in the matched pairs using McNemar's test. RESULTS: We identified 109,266 dental visits, including 39,514 (36.2%) patients who received amoxicillin and 69,752 (63.8%) patients who received third-generation cephalosporins. In the 39,514 matched pairs, the incidence of surgical site infection was 3.5% (n = 1399) for amoxicillin group and 3.7% (n = 1467) for third-generation cephalosporin group (p = 0.003). CONCLUSIONS: Amoxicillin was associated with a lower incidence of surgical site infection after impacted mandibular third molar extraction compared with third-generation cephalosporins. This result supports current guidelines and strengthens the importance of disseminating and implementing antimicrobial resistance control in dentistry.
• Trends in prophylactic antibiotic use for tooth extraction from 2015 to 2018 in Japan: An analysis using a health insurance claims database
  Misuzu Sato; Hayato Yamana; Sachiko Ono; Miho Ishimaru; Hiroki Matsui; Hideo Yasunaga
  Journal of Infection and Chemotherapy, 28, 4, 504, 509, Apr. 2022, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, INTRODUCTION: To describe patterns in antibiotic prophylaxis for tooth extraction following the 2016 Japanese National Action Plan on Antimicrobial Resistance. METHODS: Using a health insurance claims database, we retrospectively identified tooth extraction visits by patients aged ≥18 years from September 2015 to August 2018 and classified patients as undergoing extraction of a fully impacted or horizontally impacted mandibular wisdom tooth, being at risk of infective endocarditis or surgical site infection, or being at low risk. Antibiotic use and type of antibiotics prescribed on the day of tooth extraction were evaluated across the study period, with stratification by tooth extraction category and facility type (hospital or dental clinic). RESULTS: We identified 662,435 patients with tooth extraction. The mean age was 42.7 years, and 57% were male. Twelve percent underwent wisdom tooth extraction, 32% were high risk, and 10% visited hospitals. The proportion of antibiotic use was 83% overall and 82% among low-risk patients. This proportion remained similar throughout the study period. A shift from third-generation cephalosporins to amoxicillin was observed from 2015 to 2018: the proportion prescribed third-generation cephalosporins decreased from 58% to 34% in hospitals and from 57% to 56% in clinics, and the proportion prescribed amoxicillin increased from 16% to 37% in hospitals and from 6% to 10% in clinics. CONCLUSIONS: The pattern of prophylactic antibiotic use for tooth extraction gradually changed after the initiation of the National Action Plan. Further efforts are required to reduce potentially inappropriate prescriptions for low-risk patients, especially in dental clinics.
• A 5‐year longitudinal association between dietary fermented soya bean (natto) intake and tooth loss through bone mineral density in postmenopausal women: The Yokogoshi cohort study
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Toshiko Saito; Kaori Kitamura; Toshihiro Ansai; Kazutoshi Nakamura
  Gerodontology, 38, 3, 267, 275, Wiley, Sep. 2021, [International Magazine]
  English, Scientific journal
• Associations Between Periodontal Health/Treatment and Cognitive Impairment: Latest Evidence From Epidemiological Studies
  Misuzu Sato; Masanori Iwasaki; Kumiko Minagawa; Akane Miyamoto
  Current Oral Health Reports, 7, 2, 119, 128, Springer Science and Business Media {LLC}, Jun. 2020
  English, Scientific journal
• Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4-year cohort study.
  Masanori Iwasaki; George W Taylor; Misuzu Sato; Kumiko Minagawa; Toshihiro Ansai; Akihiro Yoshihara
  Journal of periodontology, 90, 8, 826, 833, Aug. 2019, [International Magazine]
  English, Scientific journal, BACKGROUND: People with chronic kidney disease (CKD) may have an increased risk of periodontal disease, but longitudinal evidence is sparse. METHODS: This 4-year cohort study assessed the association between CKD and changes in periodontal health status, defined by attachment loss (AL) progression, among older adults. Participants were 388 community-dwelling Japanese adults who were 70 years old at baseline with 7053 teeth. Estimated glomerular filtration rate (eGFR) was calculated by using baseline serum creatinine concentration. AL at six sites for every tooth was recorded at baseline and follow-up examinations. Multilevel logistic regression models estimated the tooth-specific risk of AL progression (≥1 site exhibiting a ≥3 mm increase in AL) with baseline CKD (eGFR < 60 mL/min/1.73 m2 ) as the principal exposure. RESULTS: At baseline, 27.8% of the study population (108/388 participants) had CKD. After 4 years, 21.8% of the studied teeth (1537/7053 teeth) exhibited AL progression. After applying inverse probability weighting and adjusting for potential confounders, including sex, use of devices for interdental cleaning, smoking, diabetes, tooth location, abutment for a removable denture, and highest AL, CKD was associated with significantly higher odds of AL progression (adjusted odds ratio: 1.73; 95% confidence interval: 1.15-2.60). CONCLUSIONS: The results suggest that CKD increases the risk of periodontal disease progression in older community-dwelling Japanese adults. Additional studies with more complete information, as well as in other geographic areas and age groups, are necessary to further generalize the findings.
• 地域在住高齢者における高次生活機能の加齢変化パターンと歯の本数の関連 10年間の前向きコホート研究
  岩崎 正則; 佐藤 美寿々; 葭原 明弘
  日本老年歯科医学会総会・学術大会プログラム・抄録集, 30回, P一般, 089, (一社)日本老年歯科医学会, Jun. 2019
  Japanese
• Correlation between Number of Teeth and Mortality: The Significance of Retaining 28 Teeth during Later Life
  IWASAKI Masanori; SATO Misuzu; MINAGAWA Kumiko; ANSAI Toshihiro; OGAWA Hiroshi; YOSHIHARA Akihiro
  JOURNAL OF DENTAL HEALTH, 69, 3, 131, 138, Japanese Society for Oral Health, 2019
  Japanese, This study aimed to examine trends in the number of teeth (NofT) by age, identify potential NofT trajectory patterns, and explore whether these trajectory patterns were associated with all-cause mortality among community-dwelling older adults. The study population consisted of 299 adults (baseline age, 70 years; 154 men and 145 women) who had 20 or more teeth. NofT data collected annually from 70 to 80 years of age were used to assign study members to trajectories applying group-based trajectory modeling. Three distinct NofT trajectories were identified: “retaining 28 teeth”; “mid-NofT, decreasing”; and “low-NofT, decreasing”. Survival analysis using Cox-proportional hazard modeling with a maximum follow-up of 15 years (from 70 to 85 years of age) showed that the “retaining 28 teeth” trajectory was associated with lower all-cause mortality (adjusted hazard ratio = 0.50, 95% confidence interval = 0.28‒0.89) compared with the “low-NofT, decreasing” trajectory. These study results indicate that there is heterogeneity in the trend of NofT by age among community-dwelling adults with 20 or more teeth in their 70s, and that retention of a larger number of teeth, ideally 28 teeth, during later life is associated with greater longevity.
• Association between the Numbers of Dentists/Dental Hygienists Working in Dental Clinics and Their Service Contents -From the Survey on the Cooperation of Dentistry Medical Function in Niigata-
  MINAGAWA Kumiko; YOSHIHARA Akihiro; SATO Misuzu; ARAI Setsuo; SEIDA Yoshikazu; MIYAZAKI Hideo
  JOURNAL OF DENTAL HEALTH, 69, 1, 10, 18, Japanese Society for Oral Health, 2019
  Japanese, With advanced aging, there are growing demands for the management of sick persons and medical liaison systems. In such a situation, clinics are expected to play roles as primary medical institutions, such as dealing with diverse patients and promoting community-based multi-professional collaboration. To clarify the association between the statuses of different types of professionals working in dental clinics and their service contents, a questionnaire survey was conducted, involving all dental clinics in Niigata Prefecture (1,186 as of August 1, 2012), along with examination of their service provision in July of the same year. Among these clinics, 950 that responded to the questionnaire without missing values were analyzed. With the number of dentists or dental hygienists working in the study clinics as an explanatory variable and those of dental assistants and clerks as covariances, logistic regression analysis was performed to analyze the contents of home dental care services. Ordered logistic regression analysis was also used to examine the management of patients with disabilities and the provision of feeding/swallowing guidance.
  
   The items only associated with the number of dental hygienists were home dental care services, visits to care facilities, dental hygiene guidance for care facilities, and the management of patients with disabilities (adjusted odds ratio [95% confidence interval]=1.12 [1.03-1.23], 1.11 [1.03-1.23], 1.31 [1.16-1.47], and 1.27 [1.16-1.40], respectively). The provision of feeding/swallowing guidance was only associated with the number of dentists (1.24 [1.04-1.48]).
  
   In order to promote the management of diverse patients in dental clinics and their liaison with hospitals, it may be necessary to enhance dentists’ awareness as a premise and basis for ensuring sufficient numbers of dentists and dental hygienists working in such clinics.
• Effect of lifestyle on 6-year periodontitis incidence or progression and tooth loss in older adults.
  Masanori Iwasaki; Wenche S Borgnakke; Hiroshi Ogawa; Takayuki Yamaga; Misuzu Sato; Kumiko Minagawa; Toshihiro Ansai; Akihiro Yoshihara; Hideo Miyazaki
  Journal of clinical periodontology, 45, 8, 896, 908, Aug. 2018, [International Magazine]
  English, Scientific journal, AIM: To evaluate the longitudinal association of combined healthy lifestyle factors with incidence or progression of periodontitis and tooth loss in older adults. MATERIALS AND METHODS: This 6-year study included 374 Japanese 70-year olds with 7,157 teeth, from a source eligible baseline population of 554 individuals. Four lifestyle factors-cigarette smoking, physical activity, relative weight, and dietary quality-were scored as healthy (1 point) or unhealthy (0 point). Adding the individual scores generated the "healthy lifestyle score" (0-4 points). Multilevel mixed-effects logistic regression models were applied to evaluate tooth-specific associations between the baseline healthy lifestyle score and the incidence or progression of periodontitis (increase in clinical attachment loss ≥3 mm) and tooth loss. RESULTS: After 6 years, 19.0% of the teeth exhibited periodontitis incidence or progression and 8.2% were lost. Compared with a healthy lifestyle score of 0-1 (least healthy), the highest score (4 points) was associated with a significantly lower tooth-specific risk of periodontitis (adjusted odds ratio = 0.32; 95% confidence interval: 0.16-0.62) and tooth loss (adjusted odds ratio = 0.42; 95% confidence interval: 0.23-0.77). CONCLUSIONS: Simultaneous adherence to multiple healthy lifestyle factors significantly lowers the risk of incidence or progression of periodontitis and tooth loss in older adults.
• Hyposalivation and 10-year all-cause mortality in an elderly Japanese population.
  Masanori Iwasaki; Wenche S Borgnakke; Akihiro Yoshihara; Kayoko Ito; Hiroshi Ogawa; Kaname Nohno; Misuzu Sato; Kumiko Minagawa; Toshihiro Ansai; Hideo Miyazaki
  Gerodontology, 35, 2, 87, 94, Jun. 2018, [International Magazine]
  English, Scientific journal, OBJECTIVE: To evaluate the association of salivary flow rate with all-cause mortality among older Japanese adults. We hypothesised that hyposalivation would be a marker for mortality. BACKGROUND: Hyposalivation, which is an objectively measurable decrease in salivary flow, is highly prevalent among older adults. It is associated with malnutrition and poor general health. METHODS: The study population comprised 600 community-dwelling Japanese adults (306 men and 294 women), who were 70 years old at baseline. They underwent stimulated salivary flow rate (SSFR) measurements and were followed up during a 10-year study period. After stratification by sex, the hazard ratios of all-cause mortality were estimated using Cox proportional hazards regression analysis comparing groups with and without hyposalivation (ie, SSFR < 0.7 mL/min). RESULTS: The baseline prevalence of hyposalivation was 27.8% (85/306) among men and 47.3% (139/294) among women. During a mean (standard deviation) follow-up period of 104 (27) months, 80 deaths occurred: 60 (75.0%) deaths among men and 20 (25.0%) deaths among women. After adjusting for the number of remaining teeth, smoking status, exercise, hypoalbuminemia, diabetes and cardiovascular disease, hyposalivation at baseline was significantly associated with all-cause mortality among men (adjusted hazard ratio, 1.71; 95% confidence interval, 1.01-2.89). In contrast, no association between SSFR and all-cause mortality existed among women. CONCLUSION: Hyposalivation could be a marker for all-cause mortality among older community-dwelling Japanese men. Future studies investigating the association between SSFR and cause-specific mortality are warranted.
• Dentition status and frailty in community-dwelling older adults: A 5-year prospective cohort study.
  Masanori Iwasaki; Akihiro Yoshihara; Misuzu Sato; Kumiko Minagawa; Mieko Shimada; Mamoru Nishimuta; Toshihiro Ansai; Yutaka Yoshitake; Hideo Miyazaki
  Geriatrics & gerontology international, 18, 2, 256, 262, Feb. 2018, [Domestic magazines]
  English, Scientific journal, AIM: To examine the longitudinal association between dentition status and incidence of frailty in older adults. METHODS: The present prospective cohort study included community-dwelling Japanese adults aged 75 years at baseline (n = 322). Dental examinations, biochemical blood examinations, physical performance and anthropometric measurements, and structured questionnaires were carried out at baseline. The presence of ≥20 teeth with nine or more occluding pairs of teeth was defined as functional dentition. Annual follow-up examinations, including physical performance, anthropometric measurements and structured questionnaires, were carried out over a 5-year period to determine the incidence of frailty, defined as three or more of the following five components derived from the Cardiovascular Health Study: weight loss, weakness, slowness, poor energy and low physical activity level. Adjusted hazard ratios of frailty incidence according to dentition status were calculated from Cox proportional hazards regression analyses. RESULTS: At baseline, 118 participants (36.6%) were defined as having functional dentition. During the follow up, 48 participants (14.9%) developed frailty. The adjusted hazard ratio for frailty in participants with functional dentition was 0.50 (95% confidence interval 0.25-0.98) compared with participants without functional dentition, after adjusting for sex, income, education, smoking status, body mass index, serum biomarkers and comorbidities. CONCLUSIONS: Functional dentition was significantly associated with a lower risk of frailty defined by the Cardiovascular Health Study frailty index in older Japanese adults. These results suggest that maintaining healthy and functional dentition into later life is important for frailty prevention. Geriatr Gerontol Int 2018; 18: 256-262.
• Relationship between Self-rated Tooth and Gingival Health and Self-rated General Health among General Japanese Subjects: The 8020 Health Study
  MINAGAWA Kumiko; YOSHIHARA Akihiro; SATO Misuzu; FUKAI Kakuhiro; ANDO Yuichi; SHIMAZAKI Yoshihiro; FURUTA Michiko; AIDA Jun; KANBARA Masaki; MIYAZAKI Hideo
  JOURNAL OF DENTAL HEALTH, 68, 4, 198, 206, Japanese Society for Oral Health, 2018
  Japanese, Self-rated health is a simple way of assessing the health status. It is also used for oral health research in general population surveys. However, limited information is available on younger populations aged under 65 years.
  
   Accordingly, the aim of this cross-sectional study was to investigate the association between the self-rated tooth and gingival health and self-rated general health based on a survey conducted by the 8020 Promotion Foundation in 2015.
  
   For this survey, questionnaires were mailed to 5,000 people, aged 20 to 79, who were selected by stratified two-stage random sampling from Japanese municipalities, and 2,465 people responded (response rate=49.3%).
  
   Data without missing responses from 1,972 participants were used for analysis.
  
   The subjects were divided into three groups according to age: young participants (aged 20-39 years), middle-aged participants (aged 40-59 years), and elderly participants (aged 60-79 years).
  
   An ordinal logistic regression model was created to evaluate the association between self-rated tooth and gingival health and self-rated general health for each group.
  
   Multivariable models were adjusted for the number of teeth, sex, employment status, subjective economic status, education, comorbidity, presence of an adviser, and body mass index.
  
   Based on the ordinal logistic regression analysis, participants with good self-rated tooth and gingival health had significantly better self-rated general health. The adjusted odds ratio (95% confidence interval) was 12.41 (7.22-21.34) for the young participants, 11.77 (7.50-18.48) for the middle-aged participants, and
  
  10.07 (6.55-15.50) for the elderly participants.
  
   The present study suggests that the self-rated tooth and gingival health is significantly correlated with self-rated general health among general Japanese subjects in all age groups.
• A 5-year longitudinal study of association of maximum bite force with development of frailty in community-dwelling older adults
  M. Iwasaki; A. Yoshihara; N. Sato; M. Sato; K. Minagawa; M. Shimada; M. Nishimuta; T. Ansai; Y. Yoshitake; T. Ono; H. Miyazaki
  JOURNAL OF ORAL REHABILITATION, 45, 1, 17, 24, Jan. 2018, [Peer-reviewed]
  English, Scientific journal
• Associations of Tooth Loss, Denture Use, and Self-perceived Denture Fit with Frailty in Community-dwelling Older Adults: A Cross-sectional Study
  SATO Misuzu; IWASAKI Masanori; MINAGAWA Kumiko; OGAWA Hiroshi; YAMAGA Takayuki; YOSHIHARA Akihiro; MIYAZAKI Hideo
  JOURNAL OF DENTAL HEALTH, 68, 2, 68, 75, Japanese Society for Oral Health, 2018, [Peer-reviewed], [Lead author, Corresponding author]
  Japanese,

   The aim of this cross-sectional study was to evaluate the associations of tooth loss, denture use, and self-perceived denture fit with frailty in community-dwelling older Japanese adults. The subjects were 344 Japanese adults (177 men and 167 women) aged 79 years in Niigata City (Japan), who participated in an oral and general health examination and a questionnaire survey in 2007. Frailty was defined as the presence of ≥ 2 of the following 3 factors derived and modified from the Study of Osteoporotic Fracture Criteria for Frailty: 1) weight loss ≥ 5% over 2 years, 2) inability to do chair stands, and 3) answer of "no" to the question "Do you feel full of energy?". Associations between frailty and tooth loss, denture use, and self-perceived denture fit were evaluated using logistic regression analysis. The multivariable models were adjusted for sex, body mass index, and mental health. The frequency of frailty in this study was 8.4%. Multivariable logistic regression indicated that tooth loss (per each additional tooth present, adjusted odds ratio [OR]=0.94; 95% confidence interval [CI]=0.90–0.99), the presence of 20 teeth or more (compared with the presence of less than 20 teeth, adjusted OR=0.39, 95% CI=0.15–0.97), denture non-use (compared with denture use, adjusted OR=17.89, 95% CI=5.00–64.32), and self-perceived ill-fitting denture (compared with well-fitting denture, adjusted OR=3.38, 95% CI=1.01–11.27) were significantly correlated with frailty. Our results suggest that tooth loss, denture non-use, and self-perceived ill-fitting denture were associated with frailty in community-dwelling older Japanese adults.

• Malnutrition and Oral Disease in the Elderly––Is There Any Bidirectional Relationship?
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Hideo Miyazaki
  Current Oral Health Reports, 4, 2, 70, 78, Springer Science and Business Media LLC, 21 Apr. 2017
  Scientific journal
• Association between tooth loss and medical costs related to stroke in healthy older adults aged over 75 years in Japan
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Toshihiro Ansai; Hideo Miyazaki
  Geriatrics & Gerontology International, 17, 2, 202, 210, Wiley, Feb. 2017, [Domestic magazines]
  English, Scientific journal, AIM: Growing evidence suggests that tooth loss is associated with increased risk of stroke. In the current study, we investigated cumulative medical costs related to stroke using data from the Advanced Elderly Medical Service System. We hypothesized that tooth loss was associated with an increase in medical costs related to stroke among older Japanese adults. METHODS: A total of 273 Japanese adults aged 80 years were enrolled in the current study. Baseline medical and dental examinations were carried out in June 2008. Medical care use and costs were monitored by linkage with National Health Insurance claim files from baseline to the end of February 2011. Medical costs related to stroke per month were calculated and examined for any association with the baseline number of remaining teeth using a linear regression model with robust standard errors. RESULTS: A total of 19 individuals were admitted to hospital for stroke during the follow-up period. A significant negative association was found between the number of teeth and medical costs related to stroke per month. The regression coefficients of the number of teeth in relation to medical costs related to stroke was -248 (95% CI -438 to -58, P = 0.011) in the crude model and -226 (95% CI -413 to -38, P = 0.018) after adjusting for other confounders. CONCLUSION: Within the limitations of the present study, the reported findings suggest an independent relationship of tooth loss with increase in medical cost related to stroke among older Japanese adults. Further studies are necessary to substantiate these findings. Geriatr Gerontol Int 2017; 17: 202-210.
• Longitudinal relationship of severe periodontitis with cognitive decline in older Japanese
  M. Iwasaki; A. Yoshihara; Y. Kimura; M. Sato; T. Wada; R. Sakamoto; Y. Ishimoto; E. Fukutomi; W. Chen; H. Imai; M. Fujisawa; K. Okumiya; G. W. Taylor; T. Ansai; H. Miyazaki; K. Matsubayashi
  Journal of periodontal research, 51, 5, 681, 688, 01 Oct. 2016
  Scientific journal
• Cystatin C-based estimated glomerular filtration rate and periodontitis.
  Masanori Iwasaki; George W Taylor; Misuzu Sato; Kazutoshi Nakamura; Akihiro Yoshihara; Hideo Miyazaki
  Gerodontology, 33, 3, 328, 34, Sep. 2016, [International Magazine]
  English, Scientific journal, BACKGROUND AND OBJECTIVE: Accumulating evidence suggests that decreased kidney function characterised by low estimated glomerular filtration rate (eGFR) may be associated with periodontitis. Recent studies have suggested that the use of cystatin C strengthens the association between the eGFR and the risks of adverse outcomes in decreased kidney function. The aim of this cross-sectional study was to investigate the association of cystatin C-based eGFR (eGFRcys) and creatinine-based eGFR (eGFRcreat), the commonly used method to assess kidney function, with periodontitis in 502 Japanese women (average age, 68.6 years). MATERIALS AND METHODS: GFR was estimated from serum cystatin C and serum creatinine, respectively, using the Japanese equation for GFR. Participants were classified into five groups according to their eGFRcys and eGFRcreat values. Poisson regression models with robust error variance assessed the associations of eGFRcys and eGFRcreat with periodontitis. Tests for trends were performed by fitting the five-category eGFR variables in their continuous form to the regression models. RESULTS: Participants with eGFRcys < 50 ml/min/1.73 m(2) were at significantly higher risk of periodontitis compared with the reference group (≥90 ml/min/1.73 m(2) ) (adjusted relative risk = 2.12, 95% confidence interval = 1.12 to 4.02). Additionally, there was a trend towards a higher risk of periodontitis among participants with lower eGFRcys values (p for trend in the multivariable model = 0.008). In contrast, eGFRcreat did not show a significant association with periodontitis. CONCLUSION: The findings of this study of Japanese older women showed that eGFRcys had a stronger and more linear association with periodontitis than eGFRcreat.
• Longitudinal association of dentition status with dietary intake in Japanese adults aged 75 to 80 years
  M. Iwasaki; A. Yoshihara; H. Ogawa; M. Sato; K. Muramatsu; R. Watanabe; T. Ansai; H. Miyazaki
  Journal of Oral Rehabilitation, 43, 10, 737, 744, Wiley, 21 Aug. 2016
  Scientific journal
• Maximum bite force at age 70 years predicts all-cause mortality during the following 13 years in Japanese men
  M. Iwasaki; A. Yoshihara; N. Sato; M. Sato; G. W. Taylor; T. Ansai; T. Ono; H. Miyazaki
  Journal of Oral Rehabilitation, 43, 8, 565, 574, 01 Aug. 2016
  Scientific journal
• Association between periodontitis and medical expenditure in older adults: A 33-month follow-up study
  Misuzu Sato; Masanori Iwasaki; Akihiro Yoshihara; Hideo Miyazaki
  Geriatrics & Gerontology International, 16, 7, 856, 864, Wiley, Jul. 2016, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
  English, Scientific journal, AIM: Along with rapid aging, medical expenditure for older adults has been increasing in Japan. Research has shown that periodontitis is a useful predictor for excess medical expenditure; however, limited information is available on the elderly population after adequately considering confounding factors. The aim of the present study was to evaluate the association between periodontitis and long-term medical expenditure in elderly Japanese. METHODS: Baseline health and periodontal examinations were carried out in June 2008. Japanese adults (n = 245) aged 80 years were classified into quartiles based on periodontal inflamed surface area (PISA), which quantifies the degree of periodontal inflammation. Medical care use and costs were monitored by assessment of the National Health Insurance claim files from the baseline survey through the end of February 2011. Multivariable analysis of the differences in medical expenditure among PISA quartiles was carried out using linear regression with robust standard errors. RESULTS: The participants in the fourth (with the largest PISA) and third quartiles had significantly higher inpatient medical expenditure compared with those of the first quartile (P < 0.01 and = 0.04, respectively). Participants in the fourth quartile had significantly higher total medical expenditure (P < 0.01) compared with the first quartile. A trend was observed of higher inpatient and total medical expenditure with increasing PISA. CONCLUSIONS: A significant association was found between periodontitis and future increase in medical expenditure, suggesting that periodontitis might be a modifiable factor for the reduction of excess medical expenditure among elderly Japanese. Geriatr Gerontol Int 2016; 16: 856-864.
• Serum antibody to Porphyromonas gingivalis in metabolic syndrome among an older Japanese population.
  Masanori Iwasaki; Kumiko Minagawa; Misuzu Sato; Noboru Kaneko; Susumu Imai; Akihiro Yoshihara; Hideo Miyazaki
  Gerodontology, 33, 2, 193, 200, Jun. 2016, [International Magazine]
  English, Scientific journal, BACKGROUND AND OBJECTIVE: Potentially significant associations between metabolic syndrome (MetS) and periodontal disease have been reported in recent studies; however, there is a dearth of literature regarding the relationship of MetS with serum antibody levels to periodontal pathogens. The aim of this cross-sectional study was to investigate the association between MetS and serum antibody to the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) in 216 Japanese individuals aged 79 years. MATERIALS AND METHODS: Serum antibody levels to P. gingivalis were measured by enzyme-linked immunosorbent assay. An elevated serum antibody response was defined as the upper quartile and was considered as the outcome variable. A multivariable logistic regression model was used to evaluate the association of MetS defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria with an elevated antibody status. Adjustments for gender, income, education, smoking status, dental-care utilisation patterns and brushing frequency were considered. RESULTS: The prevalence of MetS was 22.2% (n = 48). Study participants with MetS were 2.9 times more likely to have an elevated serum antibody to P. gingivalis (adjusted odds ratio = 2.91, 95% confidence interval = 1.24-6.85) after simultaneous adjustment for other covariates. CONCLUSION: Our findings suggest an independent relationship between MetS and serum antibody levels to P. gingivalis in the Japanese elderly. Additional longitudinal epidemiologic studies with larger, more diversified samples and more complete information are needed to substantiate our findings.
• Hyposalivation and dietary nutrient intake among community-based older Japanese.
  Masanori Iwasaki; Akihiro Yoshihara; Kayoko Ito; Misuzu Sato; Kumiko Minagawa; Kanako Muramatsu; Reiko Watanabe; Michael C Manz; Toshihiro Ansai; Hideo Miyazaki
  Geriatrics & gerontology international, 16, 4, 500, 7, Apr. 2016, [Domestic magazines]
  English, Scientific journal, AIM: Saliva is important for maintaining oral function and regulating oral health. Reduced saliva flow rate, which is common among older adults, has been reported to be associated with perceived chewing and swallowing difficulties; however, its relationship to actual nutrient intake is unclear. The aim of the present cross-sectional study was to evaluate the relationship between hyposalivation and nutrient intake among older Japanese adults. METHODS: The participants were 352 community-based Japanese aged 80 years. A stimulated salivary flow rate <0.5 mL/min was defined as hyposalivation. Multivariable analysis of differences in nutrient and food intake outcome variables, which were collected through a validated food frequency questionnaire, between groups with/without hyposalivation was carried out using general linear models. Models included adjustment for number of teeth, denture use, sex, income, education, body mass index, smoking status, alcohol use, diabetes, medication, activities of daily living, depression and total calorie intake. RESULTS: The hyposalivation group had significantly lower intake of n-3 polyunsaturated fatty acid, potassium, vitamin D, vitamin E, vitamin B6 and folate than the group without hyposalivation (P < 0.05) after adjusting for confounders. Vegetable, fish and shellfish consumption was significantly lower in the hyposalivation group (P < 0.05). CONCLUSIONS: Dietary intake was poorer in those with hyposalivation than among those without. A decrease in stimulated salivary flow rate could have negative effects on geriatric nutrition.
• Effects of Periodontal Diseases on Diabetes-Related Medical Expenditure
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Hideo Miyazaki
  Current Oral Health Reports, 3, 1, 7, 13, Springer Science and Business Media LLC, 13 Jan. 2016
  Scientific journal
• Oral health status in relation to cognitive function among older Japanese.
  Masanori Iwasaki; Yumi Kimura; Akihiro Yoshihara; Hiroshi Ogawa; Takayuki Yamaga; Misuzu Sato; Taizo Wada; Ryota Sakamoto; Yasuko Ishimoto; Eriko Fukutomi; Wenling Chen; Hissei Imai; Michiko Fujisawa; Kiyohito Okumiya; George W Taylor; Toshihiro Ansai; Hideo Miyazaki; Kozo Matsubayashi
  Clinical and experimental dental research, 1, 1, 3, 9, Oct. 2015, [International Magazine]
  English, Scientific journal, Epidemiologic data examining the relationship between oral health status and cognitive status are sparse, especially in Asian populations. This study aimed to assess whether periodontal disease and tooth loss were related to cognitive impairment among older Japanese. Study participants were 291 Japanese (101 men and 190 women, average age: 80.9 years), classified into three groups based on a clinical examination of oral health status: no periodontal disease, periodontal disease, and edentulous. Periodontal disease was defined using criteria recommended in the consensus report of the European Workshop in Periodontology with a modification. Cognitive impairment was defined using the results of the Mini-mental State Examination (MMSE) and Hasegawa Dementia Scale-Revised (HDS-R) scores. Multivariable logistic regression analyses assessed the relationship of the three-category oral health status variable (reference category = no periodontal disease) with low MMSE score (≤23) and low HDS-R score (≤20). Age, gender, years of education, body mass index, smoking status, drinking behavior, and history of cardiovascular disease were tested as potential confounders in the multivariable models. Periodontal disease and edentulous were significantly associated with greater odds of low cognitive performance after controlling for potential confounders. The multivariable adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for low MMSE score associated with periodontal disease and edentulous were 2.21 (1.01-4.84) and 2.28 (1.06-4.90), respectively. The multivariable adjusted ORs (95% CIs) for low HDS-R score associated with periodontal disease and edentulous were 4.85 (1.29-18.15) and 3.86 (1.05-14.20), respectively. Poor oral health status was significantly associated with cognitive impairment among community-dwelling older Japanese. Additional well-controlled longitudinal studies are needed to elucidate whether there may be a possible cause-and-effect relationship between oral health status and cognitive function.
• Longitudinal relationship between metabolic syndrome and periodontal disease among Japanese adults aged ≥70 years: the Niigata Study.
  Masanori Iwasaki; Misuzu Sato; Kumiko Minagawa; Michael C Manz; Akihiro Yoshihara; Hideo Miyazaki
  Journal of periodontology, 86, 4, 491, 8, Apr. 2015, [International Magazine]
  English, Scientific journal, BACKGROUND: There has been little evaluation in longitudinal epidemiologic studies of the effect of metabolic syndrome (MetS) on periodontal status. The specific aim of this longitudinal study is to investigate whether MetS in the Japanese population could be a risk factor for periodontal disease. METHODS: A total of 125 older adults from Japan for whom data were available for the years 2003 to 2006 were selected for the current study. Full-mouth periodontal status, measured as clinical attachment level (CAL), was recorded at baseline and in follow-up examinations. Development of periodontal disease was considered to be ≥2 teeth demonstrating a longitudinal loss of proximal attachment of ≥3 mm at the follow-up dental examination. A multivariable Poisson regression model with robust error variance was used to evaluate the association of MetS defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria with development of periodontal disease. Adjustments for sex, income, education, smoking status, number of teeth at baseline, mean CAL at baseline, pattern of visits to a dentist, and brushing frequency were considered. RESULTS: The prevalence of MetS was 21.6% (27/125). Study participants with MetS were approximately 2.6 times more likely to develop periodontal disease (adjusted relative risk 2.58, 95% confidence interval 1.17 to 5.67) after simultaneous adjustment for other covariates. CONCLUSIONS: These findings support the hypothesis that MetS may be a risk factor for periodontal disease in older Japanese individuals. Additional studies with larger, more diverse populations and more complete information are needed to substantiate the findings.
• Effect of periodontal treatment on adipokines in type 2 diabetes.
  Hiroshi Ogawa; Teerasak Damrongrungruang; Sayaka Hori; Kaname Nouno; Kumiko Minagawa; Misuzu Sato; Hideo Miyazaki
  World journal of diabetes, 5, 6, 924, 31, 15 Dec. 2014, [International Magazine]
  English, Scientific journal, The association between adipokines and inflammatory periodontal diseases has been studied over the last two decades. This review was intended to explore the observation that periodontal therapy may lead to an improvement of adipokines in diabetic patients. In summary, substantial evidence suggests that diabetes is associated with increased prevalence, extent and severity of periodontitis. Numerous mechanisms have been elucidated to explain the impact of diabetes on the periodontium. However, current knowledge concerning the role of major adipokines indicates only some of their associations with the pathogenesis of periodontitis in type 2 diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have positive effects on the diabetic condition, although evidence for this remains somewhat equivocal.
• Oral health status: relationship to nutrient and food intake among 80-year-old Japanese adults.
  Masanori Iwasaki; George W Taylor; Michael C Manz; Akihiro Yoshihara; Misuzu Sato; Kanako Muramatsu; Reiko Watanabe; Hideo Miyazaki
  Community dentistry and oral epidemiology, 42, 5, 441, 50, Oct. 2014, [International Magazine]
  English, Scientific journal, OBJECTIVES: The aim of this cross-sectional study was to investigate the relationship of oral health status defined on the basis of presence of posterior occluding pairs (POPs) and adequacy of removable denture fit as determined by self-report to nutrient and food intake among older Japanese. METHODS: The subjects were 353 Japanese aged 80 years in 2008 and were classified into four groups according to the number of POPs, defined as pairs of occluding natural, restored, or fixed prosthetic postcanine teeth (range: 0-8) and removable denture status. The groups were: (i) good dentition (n = 56; 8 POPs and no removable prosthesis), (ii) well-fitting dentures (n = 158; <8 POPs with self-reported good-fitting dentures), (iii) ill-fitting dentures (n = 70; <8 POPs with self-reported ill-fitting dentures), and (iv) compromised dentition (n = 69; <8 POPs and no removable prosthesis). Multivariable analysis of the differences in nutrient and food intake outcome variables which were collected via validated food frequency questionnaire among the four oral health status groups was conducted using general linear models. Results: Intake of multiple nutrients was significantly (P < 0.05) lower in the group with ill-fitting dentures or compromised dentition than in the good dentition group. Vegetable, fish, and shellfish consumption was significantly lower in the ill-fitting dentures or compromised dentition groups. No significant differences were seen in dietary intake between the well-fitting dentures and good dentition groups. Conclusions: Dietary intake was poorer in those with self-perceived ill-fitting dentures or fewer POPs than among those having all POPs. Regular dental care to maintain intact dentition, as well as dental treatment to replace missing teeth and ensure adequate denture fit and function, may be important to the diet intake and subsequent nutritional status of older Japanese.

• NDBオープンデータを用いた周術期等口腔機能管理関連算定状況の年次推移
  齋藤光紀; 佐藤美寿々; 岩崎正則, 口腔衛生学会雑誌(Web), 76, 2026
• 大規模コホートとリアルワールドデータを用いた口腔と全身疾患の関連についての研究
  大野幸子; 佐藤美寿々, 大規模コホートとリアルワールドデータを用いた口腔と全身疾患の関連についての研究 令和6年度 総括・分担研究報告書(Web), 2025
• 高齢者の保健事業と介護予防の一体的実施の推進及び効果検証のための研究 口腔に関する高齢者の保健事業と介護予防の一体的実施の効果検証
  渡邊裕; 佐藤美寿々, 高齢者の保健事業と介護予防の一体的実施の推進及び効果検証のための研究 令和6年度 総括・分担研究報告書(Web), 2025
• 後期高齢者における主観的口腔機能低下・歯科受診状況と新規要介護認定との関連
  阿部美也子; 佐藤美寿々; 渡邊裕; 大野幸子; 石丸美穂; 岩崎正則; 平田匠; 斎藤民; 樺山舞; 田中和美; 飯島勝矢; 津下一代, 日本公衆衛生学会総会抄録集(CD-ROM), 84th, 2025
• 幼少期の逆境体験とポジティブな経験がその後の歯痛に与える影響:横断研究
  山本貴文; 佐藤美寿々; 岩崎正則, 口腔衛生学会雑誌, 75, 増刊, 147, 147, 2025
  (一社)日本口腔衛生学会, Japanese
• 歯科領域における大規模診療報酬データベースに関する系統的レビュー
  佐藤 美寿々; 石丸 美穂; 大野 幸子; 井田 有亮, 口腔衛生学会雑誌, 74, 増刊, 113, 113, Apr. 2024
  (一社)日本口腔衛生学会, Japanese
• 糖尿病をもつ人の歯科受療行動と糖尿病診療ガイドライン改定の影響-ビッグデータを活用した実態把握及び受診につながる要因の分析
  佐藤美寿々; 佐藤美寿々; 石丸美穂; 大野幸子; 岩崎正則; 康永秀生, 8020公募研究報告書抄録(Web), 2024, 2024
• 糖尿病をもつ人における歯科受診状況の推移と糖尿病ガイドライン改定の影響
  佐藤美寿々; 佐藤美寿々; 大野幸子; 山名隼人; 石丸美穂; 岡田啓; 大野洋介; 横田勲; 岩崎正則; 康永秀生, 日本疫学会学術総会講演集(Web), 34th, 2024
• 歯周病と新規糖尿病発症の併存と年間医療費との関連:LIFE Study
  衣川安奈; 竹内研時; 竹内研時; 玉田雄大; 玉田雄大; 草間太郎; 佐藤美寿々; 福田治久; 小坂健, 口腔衛生学会雑誌, 74, 2024
• 歯周疾患に対するレセプトデータ病名・処置の妥当性の検証:LIFE Study
  大野幸子; 石丸美穂; 佐藤美寿々; 佐藤美寿々; 井田有亮; 竹内研時; 玉田雄大; 大野洋介; 村田典子; 前田恵; 福田治久, 日本疫学会学術総会講演集(Web), 34th, 2024
• 75歳居宅高齢者における口腔乾燥を起こす薬剤服薬と口腔健康状態の関連:LIFE study
  石丸美穂; 大野幸子; 佐藤美寿々; 竹内研時; 玉田雄大; 村田典子; 前田恵; 相田潤; 福田治久, 日本疫学会学術総会講演集(Web), 34th, 2024
• 高齢者の保健事業と介護予防の一体的実施の推進及び効果検証のための研究 口腔に関する高齢者の保健事業と介護予防の一体的実施の効果検証
  渡邊裕; 佐藤美寿々; 佐藤美寿々, 高齢者の保健事業と介護予防の一体的実施の推進及び効果検証のための研究 令和5年度 総括・分担研究報告書(Web), 2024
• 大規模コホートとリアルワールドデータを用いた口腔と全身疾患の関連についての研究
  大野幸子; 佐藤美寿々, 大規模コホートとリアルワールドデータを用いた口腔と全身疾患の関連についての研究 令和5年度 総括・分担研究報告書(Web), 2024
• 口腔衛生学から考えるSDH:デジタル時代の統合的アプローチ
  佐藤美寿々, 医療情報学連合大会論文集(CD-ROM), 44th, 2024
• 後期高齢者における主観的口腔機能低下・歯科受診状況と低栄養・身体的フレイルの関連
  佐藤美寿々; 岩崎正則; 渡邊裕; 石丸美穂; 大野幸子; 飯島勝矢; 遠又靖丈; 田中和美; 津下一代, 日本公衆衛生学会総会抄録集(CD-ROM), 83rd, 2024
• 高血圧患者における降圧薬の種類の違いと口腔健康状態の関連:LIFE Study
  石丸美穂; 大野幸子; 佐藤美寿々; 岡田啓; 相田潤; 村田典子; 前田恵; 福田治久, 日本公衆衛生学会総会抄録集(CD-ROM), 83rd, 502, 502, 2024
  日本公衆衛生学会, Japanese
• 複数のタバコ製品使用は歯痛と関連するか:横断研究
  山本貴文; 佐藤美寿々; 岩崎正則; 田淵貴大, 日本公衆衛生学会総会抄録集(CD-ROM), 83rd, 498, 498, 2024
  日本公衆衛生学会, Japanese
• 震災後の経済状況変化とオーラルフレイルに繋がる口腔機能低下との関連 ：因果媒介分析
  佐藤美寿々; 石丸美穂; 木野志保; 松山祐輔; 相田潤, 口腔衛生学会雑誌, 73巻増刊, May 2023, [Lead author]
• 東日本大震災被災者における震災後の外出頻度低下とオーラルフレイルに繋がる口腔機能低下との関連
  佐藤 美寿々; 石丸 美穂; 木野 志保; 松山 祐輔; 相田 潤, 口腔衛生学会雑誌, 73, 増刊, 143, 143, Apr. 2023
  (一社)日本口腔衛生学会, Japanese
• 地域歯科検診事業が成人住民の歯科利用促進に与える効果の検証:差分の差解析
  石丸美穂; 石丸美穂; 黒田直明; 黒田直明; 黒田直明; 大野幸子; 佐藤美寿々; 小宮山潤; 相田潤; 田宮菜奈子, 日本公衆衛生学会総会抄録集(CD-ROM), 82nd, 227, 227, 2023
  日本公衆衛生学会, Japanese
• 成人期における口腔の健康と全身の健康の関係性の解明のための研究 歯科医療介入の全身の健康への影響の分析
  大野幸子; 佐藤美寿々, 成人期における口腔の健康と全身の健康の関係性の解明のための研究 令和4年度 総括・分担研究報告書(Web), 2023
• 糖尿病をもつ人の歯科受療行為と糖尿病診療ガイドライン改定の影響-ビッグデータを活用した実態把握及び時系列分析
  佐藤美寿々; 佐藤美寿々; 石丸美穂; 大野幸子; 岩崎正則; 康永秀生, 8020公募研究報告書抄録(Web), 2023, 2023
• 日本におけるレセプトデータ研究の概況 スコーピングレビュー(会議録)
  須藤 茉衣子; 杉山 雄大; 今井 健二郎; 井花 庸子; 細澤 麻里子; 市瀬 雄一; 新野 真理子; 竹上 未紗; 臼田 謙太郎; 児玉 知子; 田口 怜奈; 佐藤 美寿々; 田中 素子; 竹原 健二; 磯 博康, 日本公衆衛生学会総会抄録集, 81回, 406, 406, Sep. 2022
  日本公衆衛生学会, Japanese
• 下顎埋伏智歯抜歯に伴う抜歯部位感染に対するアモキシシリンと第三世代セファロスポリン系抗菌薬の予防効果(会議録)
  佐藤美寿々; 石丸美穂, 口腔衛生学会雑誌, 72巻増刊, 増刊, 80, 80, Apr. 2022, [Lead author]
  (一社)日本口腔衛生学会, Japanese
• 抜歯処置に対する予防的抗菌薬の使用状況の年次推移 レセプトデータベース研究
  佐藤 美寿々; 山名 隼人; 大野 幸子; 石丸 美穂; 松居 宏樹; 康永 秀生, 日本公衆衛生学会総会抄録集, 80回, 264, 264, Nov. 2021, [Lead author]
  日本公衆衛生学会, Japanese
• 地域在住高齢者における歯の喪失と遊離糖類摂取量の関連(会議録)
  佐藤 美寿々; 岩崎 正則; 皆川 久美子; 宮本 茜; 葭原 明弘, 日本歯科医師会雑誌, 74, 4, 406, 406, Jul. 2021, [Lead author]
  (公社)日本歯科医師会, Japanese
• 高校生におけるインターネット依存度と永久歯う蝕との関連
  佐藤 美寿々; 皆川 久美子; 宮本 茜; 岩崎 正則, 口腔衛生学会雑誌, 70, 増刊, 112, 112, Mar. 2020
  (一社)日本口腔衛生学会, Japanese
• 地域在住高齢者における高次生活機能の加齢変化パターンと歯の本数の関連 10年間の前向きコホート研究(会議録)
  岩崎 正則; 佐藤 美寿々; 葭原 明弘, 老年歯科医学, 34, 2, 261, 261, Sep. 2019
  (一社)日本老年歯科医学会, Japanese
• 地域在住高齢者における現在歯数および義歯の使用状況・主観的評価とフレイルとの関連についての横断研究
  佐藤 美寿々, 口腔衛生学会雑誌, 69, 増刊, 66, 66, Apr. 2019
  (一社)日本口腔衛生学会, Japanese
• 動脈硬化と歯周病との関連 地域在住高齢者を対象とした横断研究
  佐藤 美寿々; 岩崎 正則; 皆川 久美子; 山賀 孝之; 小川 祐司, 口腔衛生学会雑誌, 69, 増刊, 164, 164, Apr. 2019
  (一社)日本口腔衛生学会, Japanese
• 納豆摂取と歯の喪失との関連 地域在住閉経後女性を対象とした縦断研究
  佐藤 美寿々; 岩崎 正則; 皆川 久美子; 葭原 明弘; 宮崎 秀夫, 口腔衛生学会雑誌, 68, 増刊, 112, 112, Apr. 2018
  (一社)日本口腔衛生学会, Japanese
• 高次生活機能の加齢に伴う変化の軌跡と歯の本数の関連についての縦断研究
  岩崎 正則; 佐藤 美寿々; 皆川 久美子; 安細 敏弘; 葭原 明弘; 小川 祐司; 宮崎 秀夫, 口腔衛生学会雑誌, 68, 増刊, 112, 112, Apr. 2018
  (一社)日本口腔衛生学会, Japanese
• セルフレポートによる歯周病有病者の検出についての検討
  皆川 久美子; 葭原 明弘; 佐藤 美寿々; 深井 穫博; 安藤 雄一; 嶋崎 義浩; 古田 美智子; 相田 潤; 神原 正樹; 宮崎 秀夫, 口腔衛生学会雑誌, 68, 増刊, 143, 143, Apr. 2018
  (一社)日本口腔衛生学会, Japanese
• 職域における歯科健診単独もしくは歯科健診と保健指導による行動変容
  金子 昇; 葭原 明弘; 野々村 絢子; 笹嶋 真嵩; 宮本 茜; 皆川 久美子; 佐藤 美寿々; 久保田 悠; 濃野 要; 山賀 孝之; 宮崎 秀夫, 口腔衛生学会雑誌, 68, 1, 37, 37, Jan. 2018
  (一社)日本口腔衛生学会, Japanese
• 一般地域住民における主観的口腔健康状態と全身健康状態の関連
  皆川 久美子; 葭原 明弘; 佐藤 美寿々; 深井 穫博; 安藤 雄一; 嶋崎 義浩; 古田 美智子; 相田 潤; 神原 正樹; 宮崎 秀夫, 口腔衛生学会雑誌, 68, 1, 37, 38, Jan. 2018
  (一社)日本口腔衛生学会, Japanese
• 刺激唾液分泌量低下と総死亡率との関連 地域在住高齢者における10年間のコホート研究
  佐藤 美寿々; 岩崎 正則; 伊藤 加代子; 濃野 要; 葭原 明弘; 宮崎 秀夫, 老年歯科医学, 32, 2, 159, 160, Sep. 2017, [Lead author]
  (一社)日本老年歯科医学会, Japanese
• 地域在住高齢者における最大咬合力とフレイルとの関連 5年間の前向きコホート研究
  岩崎 正則; 葭原 明弘; 佐藤 直子; 佐藤 美寿々; 安細 敏弘; 小野 高裕; 宮崎 秀夫, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 131, 131, Jun. 2017
  (一社)日本老年歯科医学会, Japanese
• 刺激唾液分泌量低下と総死亡率との関連 地域在住高齢者における10年間のコホート研究
  佐藤 美寿々; 岩崎 正則; 伊藤 加代子; 濃野 要; 葭原 明弘; 宮崎 秀夫, 日本老年歯科医学会総会・学術大会プログラム・抄録集, 28回, 155, 155, Jun. 2017
  (一社)日本老年歯科医学会, Japanese
• 地域在住高齢者における最大咬合力とフレイルとの関連 5年間の前向きコホート研究
  岩崎 正則; 葭原 明弘; 佐藤 直子; 五十嵐; 佐藤 美寿々; 安細 敏弘; 小野 高裕; 宮崎 秀夫, 老年歯科医学, 32, 2, 134, 135, Jun. 2017
  (一社)日本老年歯科医学会, Japanese
• 地域在住高齢者における健康習慣と歯の喪失・歯周病リスクの関連
  岩崎 正則; 葭原 明弘; 佐藤 美寿々; 安細 敏弘; 宮崎 秀夫, 口腔衛生学会雑誌, 67巻増刊, 増刊, 116, 116, Apr. 2017
  (一社)日本口腔衛生学会, Japanese
• 地域在住高齢者におけるフレイル(虚弱)と現在歯数との関連についての横断研究
  佐藤 美寿々; 岩崎 正則; 葭原 明弘; 宮崎 秀夫, 口腔衛生学会雑誌, 66, 1, 49, 49, Jan. 2016, [Lead author]
  (一社)日本口腔衛生学会, Japanese
• 地域在住高齢者における歯・口腔の健康が認知機能検査スコアに与える影響
  岩崎 正則; 葭原 明弘; 小川 祐司; 山賀 孝之; 佐藤 美寿々; 安細 敏弘; 宮崎 秀夫, 口腔衛生学会雑誌, 65, 2, 195, 195, Apr. 2015, [Peer-reviewed]
  (一社)日本口腔衛生学会, Japanese
• 高齢者における歯周病が医療費に及ぼす影響
  佐藤 美寿々; 岩崎 正則; 葭原 明弘; 宮崎 秀夫, 新潟歯学会雑誌, 44, 1, 56, 56, Jun. 2014, [Lead author]
  新潟歯学会, Japanese
• 8020(ハチマルニイマル)と全身の健康の関連に関する医療費分析調査
  岩崎 正則; 佐藤 美寿々; 葭原 明弘; 宮崎 秀夫, 口腔衛生学会雑誌, 64, 2, 164, 164, Apr. 2014
  (一社)日本口腔衛生学会, Japanese
• P-60 2型糖尿病患者のアディポネクチン遺伝子多型と歯周病との関連性について(ポスター)
  堀 沙耶香; 小川 祐司; 皆川 久美子; 佐藤 美寿々; 宮崎 秀夫, 口腔衛生学会雑誌, 63, 2, 195, 195, 30 Apr. 2013
  有限責任中間法人日本口腔衛生学会, Japanese

• RWDを用いた歯科疫学研究の紹介
  佐藤美寿々
  第 75 回日本口腔衛生学会 ･ 学術大会, 23 May 2026, Public symposium
  22 May 2026 - 24 May 2026
• Trends In Dental Visit Among People With Diabetes In Japan
  Misuzu Sato; Miho Ishimaru; Sachiko Ono; Masanori Iwasaki
  2026 IADR/AADOCR/CADR General Session, 27 Mar. 2026
• 口腔衛生学から考えるSDH：デジタル時代の統合的アプローチ
  佐藤美寿々
  第44回医療情報学連合大会, 24 Nov. 2024, Public symposium
  21 Nov. 2024 - 24 Nov. 2024
• 後期高齢者における主観的口腔機能低下・歯科受診状況と低栄養・身体的フレイルの関連
  佐藤美寿々; 岩﨑正則; 渡邊裕; 石丸美穂; 大野幸子; 飯島勝矢; 遠又靖丈; 田中和美; 津下一代
  第83回日本公衆衛生学会総会, 31 Oct. 2024
  29 Oct. 2024 - 31 Oct. 2024
• 歯科領域における大規模診療報酬データベースに関する系統的レビュー
  佐藤 美寿々; 石丸 美穂; 大野 幸子; 井田 有亮
  口腔衛生学会雑誌, Apr. 2024, (一社)日本口腔衛生学会, Japanese
  Apr. 2024 - Apr. 2024
• Effect of Periodontal Therapy on Glycemic Control in Type2 Diabetes
  M. Sato; S. Ono; H. Yamana; A. Okada; M. Ishimaru; Y. Ono; M. Iwasaki; J. Aida; H. Yasunaga
  2024 IADR/AADOCR/CADR General Session & Exhibition, 15 Mar. 2024
• 糖尿病をもつ人における歯科受診状況の推移と糖尿病ガイドライン改定の影響
  佐藤 美寿々; 大野 幸子; 山名 隼人; 石丸 美穂; 岡田 啓; 大野 洋介; 横田 勲; 岩崎 正則; 康永 秀生
  第34回日本疫学会学術総会, 02 Feb. 2024
• 75歳居宅高齢者における口腔乾燥を起こす薬剤服薬と口腔健康状態の関連：LIFE study
  石丸 美穂; 大野 幸子; 佐藤 美寿々; 竹内 研時; 玉田 雄大; 村田 典子; 前田 恵; 相田 潤; 福田 治久
  第34回日本疫学会学術総会, 02 Feb. 2024
• 歯周疾患に対するレセプトデータ病名・処置の妥当性の検証：LIFE Study
  大野 幸子; 石丸 美穂; 佐藤 美寿々; 井田 有亮; 竹内 研時; 玉田 雄大; 大野 洋介; 村田 典子; 前田 恵; 福田 治久
  第34回日本疫学会学術総会, Feb. 2024
• 糖尿病をもつ人における歯科受診状況の推移と糖尿病ガイドライン改定の影響
  佐藤 美寿々; 大野 幸子; 山名 隼人; 石丸 美穂; 岡田 啓; 大野 洋介; 横田 勲; 岩崎 正則; 康永 秀生
  Journal of Epidemiology, Jan. 2024, (一社)日本疫学会, Japanese
  Jan. 2024 - Jan. 2024
• 75歳居宅高齢者における口腔乾燥を起こす薬剤服薬と口腔健康状態の関連 LIFE study
  石丸 美穂; 大野 幸子; 佐藤 美寿々; 竹内 研時; 玉田 雄大; 村田 典子; 前田 恵; 相田 潤; 福田 治久
  Journal of Epidemiology, Jan. 2024, (一社)日本疫学会, Japanese
  Jan. 2024 - Jan. 2024
• 歯周疾患に対するレセプトデータ病名・処置の妥当性の検証 LIFE Study
  大野 幸子; 石丸 美穂; 佐藤 美寿々; 井田 有亮; 竹内 研時; 玉田 雄大; 大野 洋介; 村田 典子; 前田 恵; 福田 治久
  Journal of Epidemiology, Jan. 2024, (一社)日本疫学会, Japanese
  Jan. 2024 - Jan. 2024
• 2 型糖尿病のある人における歯周治療が血糖管理に与える影響
  佐藤美寿々; 大野幸子; 山名隼人; 岡田啓; 石丸美穂; 大野洋介; 岩崎正則; 相田潤; 康永秀生
  日本臨床疫学会第6回年次学術大会, 12 Nov. 2023
• 地域歯科検診事業が成人住民の歯科利用促進に与える効果の検証 差分の差解析
  石丸 美穂; 黒田 直明; 大野 幸子; 佐藤 美寿々; 小宮山 潤; 相田 潤; 田宮 菜奈子
  日本公衆衛生学会総会抄録集, Oct. 2023, 日本公衆衛生学会, Japanese
  Oct. 2023 - Oct. 2023
• 震災後の経済状況変化とオーラルフレイルに繋がる口腔機能低下との関連 ：因果媒介分析
  佐藤美寿々; 石丸美穂; 木野志保; 松山祐輔; 相田潤
  口腔衛生学会雑誌, May 2023
  May 2023 - May 2023
• 東日本大震災被災者における震災後の外出頻度低下とオーラルフレイルに繋がる口腔機能低下との関連
  佐藤 美寿々; 石丸 美穂; 木野 志保; 松山 祐輔; 相田 潤
  口腔衛生学会雑誌, Apr. 2023, (一社)日本口腔衛生学会, Japanese
  Apr. 2023 - Apr. 2023
• 日本におけるレセプトデータ研究の概況 スコーピングレビュー(会議録)
  須藤 茉衣子; 杉山 雄大; 今井 健二郎; 井花 庸子; 細澤 麻里子; 市瀬 雄一; 新野 真理子; 竹上 未紗; 臼田 謙太郎; 児玉 知子; 田口 怜奈; 佐藤 美寿々; 田中 素子; 竹原 健二; 磯 博康
  日本公衆衛生学会総会抄録集, Sep. 2022
  Sep. 2022 - Sep. 2022
• 下顎埋伏智歯抜歯に伴う抜歯部位感染に対するアモキシシリンと第三世代セファロスポリン系抗菌薬の予防効果(会議録)
  佐藤美寿々; 石丸美穂
  口腔衛生学会雑誌, Apr. 2022
  Apr. 2022 - Apr. 2022
• 抜歯処置に対する予防的抗菌薬の使用状況の年次推移 レセプトデータベース研究
  佐藤 美寿々; 山名 隼人; 大野 幸子; 石丸 美穂; 松居 宏樹; 康永 秀生
  日本公衆衛生学会総会抄録集, Nov. 2021, 日本公衆衛生学会, Japanese
  Nov. 2021 - Nov. 2021
• 地域在住高齢者における歯の喪失と遊離糖類摂取量の関連(会議録)
  佐藤 美寿々; 岩崎 正則; 皆川 久美子; 宮本 茜; 葭原 明弘
  日本歯科医師会雑誌, Jul. 2021
  Jul. 2021 - Jul. 2021
• 高校生におけるインターネット依存度と永久歯う蝕との関連
  佐藤 美寿々; 皆川 久美子; 宮本 茜; 岩崎 正則
  口腔衛生学会雑誌, Mar. 2020, (一社)日本口腔衛生学会, Japanese
  Mar. 2020 - Mar. 2020
• 地域在住高齢者における高次生活機能の加齢変化パターンと歯の本数の関連 10年間の前向きコホート研究(会議録)
  岩崎 正則; 佐藤 美寿々; 葭原 明弘
  老年歯科医学, Sep. 2019
  Sep. 2019 - Sep. 2019
• 動脈硬化と歯周病との関連 地域在住高齢者を対象とした横断研究
  佐藤 美寿々; 岩崎 正則; 皆川 久美子; 山賀 孝之; 小川 祐司
  口腔衛生学会雑誌, Apr. 2019, (一社)日本口腔衛生学会, Japanese
  Apr. 2019 - Apr. 2019
• セルフレポートによる歯周病有病者の検出についての検討
  皆川 久美子; 葭原 明弘; 佐藤 美寿々; 深井 穫博; 安藤 雄一; 嶋崎 義浩; 古田 美智子; 相田 潤; 神原 正樹; 宮崎 秀夫
  口腔衛生学会雑誌, Apr. 2018, (一社)日本口腔衛生学会, Japanese
  Apr. 2018 - Apr. 2018
• 高次生活機能の加齢に伴う変化の軌跡と歯の本数の関連についての縦断研究
  岩崎 正則; 佐藤 美寿々; 皆川 久美子; 安細 敏弘; 葭原 明弘; 小川 祐司; 宮崎 秀夫
  口腔衛生学会雑誌, Apr. 2018, (一社)日本口腔衛生学会, Japanese
  Apr. 2018 - Apr. 2018
• 納豆摂取と歯の喪失との関連 地域在住閉経後女性を対象とした縦断研究
  佐藤 美寿々; 岩崎 正則; 皆川 久美子; 葭原 明弘; 宮崎 秀夫
  口腔衛生学会雑誌, Apr. 2018, (一社)日本口腔衛生学会, Japanese
  Apr. 2018 - Apr. 2018
• 一般地域住民における主観的口腔健康状態と全身健康状態の関連
  皆川 久美子; 葭原 明弘; 佐藤 美寿々; 深井 穫博; 安藤 雄一; 嶋崎 義浩; 古田 美智子; 相田 潤; 神原 正樹; 宮崎 秀夫
  口腔衛生学会雑誌, Jan. 2018, (一社)日本口腔衛生学会, Japanese
  Jan. 2018 - Jan. 2018
• 職域における歯科健診単独もしくは歯科健診と保健指導による行動変容
  金子 昇; 葭原 明弘; 野々村 絢子; 笹嶋 真嵩; 宮本 茜; 皆川 久美子; 佐藤 美寿々; 久保田 悠; 濃野 要; 山賀 孝之; 宮崎 秀夫
  口腔衛生学会雑誌, Jan. 2018, (一社)日本口腔衛生学会, Japanese
  Jan. 2018 - Jan. 2018
• 刺激唾液分泌量低下と総死亡率との関連 地域在住高齢者における10年間のコホート研究
  佐藤 美寿々; 岩崎 正則; 伊藤 加代子; 濃野 要; 葭原 明弘; 宮崎 秀夫
  老年歯科医学, Sep. 2017
  Sep. 2017 - Sep. 2017
• 地域在住高齢者における最大咬合力とフレイルとの関連 5年間の前向きコホート研究
  岩崎 正則; 葭原 明弘; 佐藤 直子; 五十嵐; 佐藤 美寿々; 安細 敏弘; 小野 高裕; 宮崎 秀夫
  老年歯科医学, Jun. 2017
  Jun. 2017 - Jun. 2017
• 地域在住高齢者における健康習慣と歯の喪失・歯周病リスクの関連
  岩崎 正則; 葭原 明弘; 佐藤 美寿々; 安細 敏弘; 宮崎 秀夫
  口腔衛生学会雑誌, Apr. 2017
  Apr. 2017 - Apr. 2017
• 地域在住高齢者におけるフレイル(虚弱)と現在歯数との関連についての横断研究
  佐藤 美寿々; 岩崎 正則; 葭原 明弘; 宮崎 秀夫
  口腔衛生学会雑誌, Jan. 2016
  Jan. 2016 - Jan. 2016
• The association between periodontitis and medical expenditure in elderly type 2 diabetes patients.
  Sato M; Iwasaki M; Yoshihara A; Miyazaki H
  第63回国際歯科研究学会日本部会総会・学術大会
  30 Oct. 2015 - 31 Oct. 2015
• 地域在住高齢者における歯・口腔の健康が認知機能検査スコアに与える影響
  岩崎 正則; 葭原 明弘; 小川 祐司; 山賀 孝之; 佐藤 美寿々; 安細 敏弘; 宮崎 秀夫
  口腔衛生学会雑誌, Apr. 2015, (一社)日本口腔衛生学会, Japanese
  Apr. 2015 - Apr. 2015
• 高齢者における歯周病が医療費に及ぼす影響
  佐藤 美寿々; 岩崎 正則; 葭原 明弘; 宮崎 秀夫
  新潟歯学会雑誌, Jun. 2014
  Jun. 2014 - Jun. 2014
• 8020(ハチマルニイマル)と全身の健康の関連に関する医療費分析調査
  岩崎 正則; 佐藤 美寿々; 葭原 明弘; 宮崎 秀夫
  口腔衛生学会雑誌, Apr. 2014
  Apr. 2014 - Apr. 2014
• P-60 2型糖尿病患者のアディポネクチン遺伝子多型と歯周病との関連性について(ポスター)
  堀 沙耶香; 小川 祐司; 皆川 久美子; 佐藤 美寿々; 宮崎 秀夫
  口腔衛生学会雑誌, 30 Apr. 2013, 有限責任中間法人日本口腔衛生学会, Japanese
  30 Apr. 2013 - 30 Apr. 2013

• 予防歯科学, 2024年, 博士後期課程, 歯学院
• 予防歯科学研究Ⅰ, 2024年, 博士後期課程, 歯学院
• 予防歯科学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅰ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅲ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅳ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅴ, 2024年, 博士後期課程, 歯学院
• 基本技法, 2024年, 博士後期課程, 歯学院
• 社会口腔保健学, 2024年, 博士後期課程, 歯学院
• 社会口腔保健学研究Ⅰ, 2024年, 博士後期課程, 歯学院
• 社会口腔保健学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 食の科学, 2024年, 学士課程, 歯学部
• 衛生公衆衛生学・予防歯科学Ⅰ, 2024年, 学士課程, 歯学部
• 衛生公衆衛生学・予防歯科学Ⅱ, 2024年, 学士課程, 歯学部
• 衛生公衆衛生学・予防歯科学基礎実習, 2024年, 学士課程, 歯学部
• 予防歯科学臨床実習Ⅰ, 2024年, 学士課程, 歯学部
• 予防歯科学臨床実習Ⅱ, 2024年, 学士課程, 歯学部
• 社会歯科学, 2024年, 学士課程, 歯学部

• Aug. 2023 - Present
  日本疫学会
• Jul. 2021 - Present
  日本公衆衛生学会
• Aug. 2019 - Present
  日本臨床疫学会
• Apr. 2017 - Present
  日本老年歯科医学会
• Feb. 2013 - Present
  日本口腔衛生学会

• 世界初の包括的歯科情報データベース構築による歯周病と全身疾患の関連の定量的解明
  科学研究費助成事業
  01 Apr. 2026 - 31 Mar. 2030
  大野 幸子; 竹内 研時; 星 和人; 福田 治久; 井田 有亮; 石丸 美穂; 佐藤 美寿々; 相田 潤
  日本学術振興会, 基盤研究(B), 東京大学, 26K02599
• 歯周病がサルコペニア発症に与える影響の解明とリスクエンジンの開発：国際共同研究
  科学研究費助成事業
  01 Apr. 2025 - 31 Mar. 2029
  岩崎 正則; 平野 浩彦; 吉田 明弘; 中村 純也; 佐藤 美寿々; 小川 祐司
  日本学術振興会, 基盤研究(B), 北海道大学, 25K02833
• ビッグデータを用いた障がい者における歯科医療提供体制の見える化と潜在需要の推計
  科学研究費助成事業
  01 Apr. 2024 - 31 Mar. 2027
  佐藤 美寿々
  日本学術振興会, 若手研究, 北海道大学, 24K20093
• ビッグデータを用いたダウン症等に対するスペシャルニーズ歯科医療提供体制の実態把握
  科学研究費助成事業
  31 Aug. 2023 - 31 Mar. 2025
  佐藤 美寿々
  世界保健機関からGlobal Oral Health Action Plan (2023-2030)が新たに発出され、 全ての人に対する口腔保健の重要性が改めて強調された。なかでも、スペシャルケアを必要とする障がい者は、口腔疾患に罹患しやすいにも関わらず歯科へのアクセスが困難であることが大きな課題となっている。
  障がい者の中でも、ダウン症候群は比較的頻度の高い常染色体異常であり、歯周疾患の治療・定期管理の有用性や早期からの摂食機能療法の実施症例が報告されている。しかし、ダウン症候群をはじめとする障がい者に対する、個人診療所を含めた実臨床における歯科医療及び摂食機能療法の実施状況の全国的な動向は未だ明らかとなっていない。
  本研究の目的は、歯科ビッグデータを擁する大規模診療報酬データベースを用い、 個人歯科診療所を含む全国規模で、ダウン症候群をはじめとした障がい者に対する歯科処置及び摂食機能療法等スペシャルニーズ歯科医療の提供体制について実態把握を行うことである。
  2023年度は、大規模診療報酬データベースを用い、医科・歯科診療報酬レセプトデータの抽出、 結合、クリーニングを行い、ダウン症候群を含む対象者の同定、データセットの構築を行なった。
  また、予備的研究として、医科・歯科及び健診データを擁する大規模診療報酬データベースを用いて、一般集団での糖尿病をもつ人における歯周治療の効果を検証する研究を実施し、国内外での学会発表及び論文公表を行なった。
  日本学術振興会, 研究活動スタート支援, 北海道大学, 23K19735