Researcher basic information

• 学士（歯学）, Hokkaido University, Mar. 2006
• 博士（歯学）, 新潟大学, Mar. 2010

• https://researchmap.jp/masanori.iwasaki?lang=en

• 80584614

• 201001094709049490

• 口腔衛生学
• 予防歯科学
• 老年歯科医学

• Life Science, Social dentistry

• Bachelor's degree program, School of Dental Medicine
• Doctoral (PhD) degree program, Graduate school of Dental Medicine

Research activity information

• Aug. 2024, Gerodontology, The Robin Heath Citation Award 2024
• Jun. 2023, 日本老年医学会 Geriatrics & Gerontology International Best reviewer award 2022
• Jun. 2019, 日本老年歯科医学会, 優秀奨励論文賞（ライオンアワード）
  岩﨑 正則
• 2018, 日本口腔衛生学会, 学術賞 LION AWARD
  岩﨑 正則
• 2012, 日本口腔衛生学会, 論文奨励賞
  岩﨑 正則
• 2010, JADR, Young Investigator Award of JADR
  Iwasaki Masanori

• Is Appendicular Lean Soft Tissue Mass a Clinically Valid Diagnostic Marker for Sarcopenia?
  Yosuke Osuka; Sho Hatanaka; Narumi Kojima; Takashi Shida; Takahisa Ohta; Keiko Motokawa; Ayako Edahiro; Maki Shirobe; Masanori Iwasaki; Hirohiko Hirano; Shuichi Awata; Hiroyuki Sasai
  Geriatrics & gerontology international, 18 Nov. 2025, [Domestic magazines]
  English, Scientific journal, AIM: Geriatric experts have long debated the inclusion of appendicular lean soft tissue mass (ALSTM) in the diagnostic criteria for sarcopenia. This study examined whether a diagnostic model for sarcopenia that excludes appendicular lean soft tissue mass (ALSTM) is equivalent to one that includes ALSTM in discriminating health-related outcomes. METHODS: Community-dwelling older adults from the Itabashi Longitudinal Study on Aging in Tokyo, Japan, were included. Based on the AWGS2019 criteria, we developed two diagnostic models: Model 1, including low handgrip strength/gait speed and low ALSTM assessed by bioelectrical impedance analysis, and Model 2, excluding low ALSTM. Health-related outcomes were self-reported falls and hospitalization in the past year. Differences in area under the receiver operating characteristic curve (AUC) and 95% confidence intervals (CI) between the two models were estimated using 1000 bootstrap samples. RESULTS: In total, 2432 participants (median age: 76 years; 53.2% men) without missing data were analyzed. Falls and hospitalization were reported by 17.8% and 15.3% of participants, respectively. The AUCs [95% CIs] of Models 1 and 2 were 0.61 [0.59, 0.64] and 0.61 [0.58, 0.64] for falls and 0.65 [0.62, 0.68] and 0.64 [0.61, 0.67] for hospitalization, respectively. The differences (Model 2-Model 1) in AUCs [95% CI] between the two models were -0.004 [-0.015, 0.006] for falls and -0.004 [-0.014, 0.004] for hospitalization, with the CIs within the pre-specified equivalence margin (±0.05). CONCLUSIONS: Diagnostic models excluding ALSTM demonstrated equivalent discrimination ability to those including ALSTM, raising questions about the necessity of ALSTM assessment for sarcopenia diagnosis.
• Oral Frailty, Dental Visits, and Healthy Life Expectancy: A 6-Year Prospective Cohort Among Japanese Older Adults
  Safira Khairinisa; Sakura Kiuchi; Yusuke Matsuyama; Masanori Iwasaki; Jun Aida
  GERIATRICS & GERONTOLOGY INTERNATIONAL, 21 Oct. 2025
  English, Scientific journal
• Relationship between end of life of older adults in long-term care facilities and full-time dental hygienist service: A 2-year multicenter study
  Nami Machi; Yutaka Watanabe; Kazuhito Miura; Kimiya Ozaki; Misuzu Sato; Masanori Iwasaki; Maki Shirobe; Hirohiko Hirano; Yuki Ohara; Yoshihiro Kugimiya; Masataka Itoda; Takeshi Kikutani; Midori Tsuneishi; Yuko Kuboyama; Shinsuke Mizutani; Shigekazu Komoto; Yutaka Yamazaki
  GERIATRICS & GERONTOLOGY INTERNATIONAL, 16 Sep. 2025
  English, Scientific journal
• Effect of health promotion interventions in supermarkets on dietary variety among Japanese older adults: a protocol for a cluster non-randomised parallel-group comparative trial.
  Tatsunosuke Gomi; Keiko Motokawa; Maki Shirobe; Masanori Iwasaki; Misato Hayakawa; Ayako Edahiro; Hirohiko Hirano
  BMJ open, 15, 9, e099985, 03 Sep. 2025, [International Magazine]
  English, Scientific journal, INTRODUCTION: With an ageing population, prevention of frailty among older adults has become a critical public health issue. Dietary habits are one of the essential components in frailty prevention, which involves promoting changes in dietary behaviours, such as including dietary variety. However, community-level health promotion interventions face significant challenges, including limited spatial access to food, which is important as it is not easy to change the behaviour of older adults. The dissemination of community-level health promotion interventions targeting dietary behavioural changes among older adults remains unclear. Therefore, this study aimed to evaluate the effects of supermarket-based health promotion interventions on dietary variety among older Japanese adults. METHODS AND ANALYSIS: This study is a cluster non-randomised parallel-group comparative trial involving 15 supermarkets in the Yamanashi and Nagano Prefectures, Japan. Seven supermarkets will be assigned to the intervention group and eight to the control group. The intervention group will receive a health promotion programme consisting of three components to enhance dietary diversity: information, education and support delivery. The intervention design incorporates social marketing strategies, and programme evaluation will be conducted concurrently. Data, including the Dietary Variety Score (DVS) for the primary outcome, will be collected through postal and electronic surveys at baseline and at 1, 2 and 3 years, with the 3-year follow-up serving as the primary endpoint for effectiveness evaluation. Statistical analyses will use a generalised linear mixed model, focusing on changes in the DVS as the primary outcome. Sensitivity and subgroup analyses will be performed to assess the generalisability of the findings. ETHICS AND DISSEMINATION: The Tokyo Metropolitan Institute for Geriatrics and Gerontology Research Ethics Committee has approved the research protocol (approval number: R23-116). The results will be disseminated through conference presentations and publication in peer-reviewed international journals. TRIAL REGISTRATION NUMBER: UMIN000056023.
• Periodontal Inflammation and Serum Inflammatory Markers in Community-Dwelling Older Adults in Japan: The Otassha Study.
  Masanori Iwasaki; Maki Shirobe; Yuki Ohara; Keiko Motokawa; Takashi Shida; Yoshiko Motohashi; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Yutaka Watanabe; Hiroyuki Sasai; Shuichi Obuchi; Hirohiko Hirano
  Journal of clinical periodontology, 52, 8, 1099, 1107, Aug. 2025, [International Magazine]
  English, Scientific journal, AIM: To investigate the associations between periodontal inflammation-as determined by the periodontal inflamed surface area (PISA)-and serum inflammatory markers in community-dwelling older adults in Japan. MATERIALS AND METHODS: This cross-sectional study included 470 adults (mean age: 73.1 years). The composite inflammatory marker z-score (CIMZ) was calculated as the sum of the participants' individual z-scores for C-reactive protein (CRP), interleukin-1beta (IL-1β), IL-6 and tumour necrosis factor-α (TNF-α). The associations of PISA (quartiles) with individual biomarkers (continuous, log-transformed) and CIMZ (dichotomized, highest quartile or not) were assessed using linear or Poisson regression models. RESULTS: Compared with participants in the lowest PISA quartile (Q1), those in Q3 and Q4 had significantly (p < 0.05) higher CRP and IL-6 levels. Statistically significant linear trends (p trend < 0.05) across the PISA quartiles were observed for CRP and IL-6. The multivariable adjusted prevalence ratios (95% confidence intervals) of high CIMZ (reference: Q1) were 1.20 (0.68-2.14), 1.66 (0.96-2.88) and 1.90 (1.08-3.34) (p trend = 0.01) in individuals in PISA Q2-Q4. CONCLUSIONS: Older adults with high periodontal inflammation had high serum CRP and IL-6 concentrations and composite summary inflammatory indicator values. Periodontal inflammation is a potential modifiable factor of elevated inflammatory status among older adults in Japan.
• Descriptive Epidemiology of Oral Function in Middle-Aged and Older Japanese Individuals.
  Maki Shirobe; Masanori Iwasaki; Kentaro Igarashi; Keiko Motokawa; Ayako Edahiro; Shiho Morishita; Chiaki Matsubara; Tatsunosuke Gomi; Manami Ejiri; Hisashi Kawai; Maki Inoue; Shino Yamaguchi; Ayaka Isobe; Hisako Hikiji; Tatsuji Nishihara; Hiroyuki Sasai; Kazushige Ihara; Yoshinori Fujiwara; Shuichi Obuchi; Hirohiko Hirano
  Gerodontology, 02 Jul. 2025, [International Magazine]
  English, Scientific journal, OBJECTIVE: To describe age-group differences in oral function in middle-aged and older Japanese adults. BACKGROUND: To facilitate oral function management, it is essential research spanning a wider age range. MATERIALS AND METHODS: We conducted a secondary analysis of data in 2023 from two distinct populations. The Otassha Study included community-dwelling adults aged ≥ 65 years in Tokyo. The second sample consisted of middle-aged workers aged ≥ 40 years employed at municipal offices in Fukuoka. Survey items included tongue coating index, mucosal wetness, occlusal force, oral diadochokinesis, tongue pressure, masticatory function, swallowing function and the prevalence of oral hypofunction. Trend tests and binary logistic regression analysis were conducted. The dependent variable was the presence of oral hypofunction, and the independent variable was the age group. RESULTS: Our analysis included 645 participants (275 men and 370 women, aged 40-89 years). The prevalence of oral hypofunction and low oral function in six elements, except mucosal wetness, showed a significant linear association by age group. The prevalence of oral hypofunction was higher in the 80s (adjusted odds ratio: 3.4, 95% confidence interval: 1.4-8.3) than in the reference category (60s). CONCLUSION: Expanding middle-aged participant data and conducting longitudinal studies are essential for understanding age-related changes in oral function. These efforts will help inform effective strategies to address oral functional decline.
• Dental visit avoidance during the COVID-19 pandemic is associated with oral frailty in Japanese community-dwelling older adults.
  Masanori Iwasaki; Maki Shirobe; Keiko Motokawa; Asuka Takeda; Yosuke Osuka; Narumi Kojima; Hiroyuki Sasai; Hiroki Inagaki; Fumiko Miyamae; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata
  Geriatrics & gerontology international, 25, 6, 758, 763, Jun. 2025, [Domestic magazines]
  English, Scientific journal, AIM: Dental visits; that is, receiving oral healthcare and treatment by dental professionals, are important for maintaining oral health. Owing to the possibility of contracting COVID-19, individuals have been reluctant to visit medical institutions. How the oral function of older individuals in Japan has been affected by dental visit avoidance is unknown. We examined the association between COVID-19-related dental visit avoidance and oral frailty status among community-dwelling older adults. METHODS: This cross-sectional study targeted community-dwelling adults aged ≥70 years who participated in the Itabashi Longitudinal Study on Aging. Those with self-perceived dental care needs and without incomplete data were included in the analysis. Oral frailty was assessed using the Oral Frailty 5-item Checklist. Dental visit status during the COVID-19 pandemic was determined via questionnaire. Poisson regression analysis was used, in which dental visit status (3 categories: COVID-19-related dental visit avoidance; dental visit avoidance for other reasons; and no dental visit avoidance [reference]) was set as the independent variable, and oral frailty (present or absent) was set as the dependent variable. RESULTS: Among the 854 participants analyzed (average age 77.8 years, 377 men and 477 women), 50.2% had oral frailty, and 13.1% avoided dental visits because of COVID-19, even when they had something wrong with their mouth. After adjusting for health characteristics and sociodemographic background, COVID-19-related dental visit avoidance was associated with oral frailty (prevalence ratio 1.24, 95% confidence interval 1.05-1.48). CONCLUSIONS: Our study showed a greater oral frailty prevalence among community-dwelling older adults who avoided dental visits because of COVID-19. Geriatr Gerontol Int 2025; 25: 758-763.
• Dietary n-6 and n-3 Polyunsaturated Fatty Acids and Tooth Loss in Community-Dwelling Older Japanese People.
  Akihiro Yoshihara; Masanori Iwasaki; Kana Suwama; Ayuko Odajima; Keiko Kabasawa; Yumi Ito; Junta Tanaka
  Gerodontology, 04 Apr. 2025, [International Magazine]
  English, Scientific journal, OBJECTIVE: This study investigated the associations between baseline n-6 and n-3 polyunsaturated fatty acid levels and the number of teeth lost subsequently over 5 years. BACKGROUND: The relationship between n-3 and n-6 polyunsaturated fatty acids and tooth loss remains unclear. Previous studies have been limited to older individuals aged 70 and above, and no research has been conducted that takes into account a broader age range. MATERIAL AND METHODS: Participants (n = 1534) attended both the baseline survey and the follow-up survey conducted 5 years later. Poisson regression analyses were conducted after converting the number of teeth present at baseline into an adjustment variable. The dependent variable was the number of lost teeth over a five-year period. The exposure variables were each quintile of self-reported n-3 and n-6 polyunsaturated fatty acid intake levels (g/1000 kcal) and the ratio of self-reported n-6 to n-3 polyunsaturated fatty acid intake levels (n-6:n-3 ratio) adjusted by age, sex, smoking, use of dental floss or interdental brush and history of diabetes mellitus. RESULTS: Higher n-3 fatty acid intake (5th quintile, incidence rate ratio (IRR): 0.21, p < 0.001) and a lower dietary n-6:n-3 ratio (≤ 4.0) significantly lower tooth loss risk. Conversely, higher n-6 intake (5th quintile, IRR: 1.32, p = 0.006) was associated with the likelihood of tooth loss. Younger age, flossing and adequate chewing ability were associated with better dental outcomes. CONCLUSION: Balanced dietary intake, particularly higher n-3 fatty acids and a lower n-6:n-3 ratio, helps preserve dental health by reducing tooth loss risk.
• Relationship between masticatory function and sarcopenic obesity in community-dwelling older adults aged 75 or older: a cross-sectional study.
  Hikaru Shiraki; Satoko Kakuta; Yumi Kimura; Masanori Iwasaki; Chihiro Masaki; Taizo Wada; Kozo Matsubayashi; Yasuko Ishimoto; Michiko Fujisawa; Kiyohito Okumiya; Ryuji Hosokawa; Ryota Sakamoto; Toshihiro Ansai
  BMC geriatrics, 25, 1, 191, 191, 22 Mar. 2025, [International Magazine]
  English, Scientific journal, OBJECTIVE: The relationship between sarcopenic obesity and masticatory function is poorly understood. This study aims to explore this association in community-dwelling individuals aged 75 years or older. METHODS: This study analyzed data from 236 community-dwelling adults aged 75 years or older. Masticatory function was assessed using spectrophotometric measurement of gum color differences before and after chewing color-changeable gum (ΔE*ab). Participants were categorized into tertiles of masticatory function based on their ΔE*ab values. The tertiles were defined as low, intermediate, and high. Sarcopenic obesity was assessed using the Consensus statement of the Japanese Working Group on Sarcopenic Obesity. Bayesian multinomial logistic regression was employed to examine the relationship between masticatory function and sarcopenic obesity. RESULTS: The prevalence rates for obesity, sarcopenia, and sarcopenic obesity were 15.3%, 24.2%, and 9.7%, respectively. After adjusting for covariates, participants with high masticatory function had a significantly lower posterior estimate of sarcopenic obesity (posterior estimate: -1.83 [95% credible interval: -3.66, -0.22]) and sarcopenia (posterior estimate: -1.97 [95% credible interval: -3.37, -0.72]) compared with participants with low masticatory function. However, no significant associations were observed between masticatory function and obesity. CONCLUSIONS: These findings suggest that high masticatory function is associated with a significantly lower prevalence of sarcopenic obesity in older adults.
• Oral Health Management by Dental Hygienists and Older Adults' Food Forms in Long‐Term Care Facilities: A 1‐Year Longitudinal Study
  Kaoru Inamoto; Kimiya Ozaki; Yutaka Watanabe; Yutaka Yamazaki; Yuki Ohara; Masanori Iwasaki; Hirohiko Hirano; Midori Tsuneishi; Tsuyoshi Kodama; Mitsuyoshi Yoshida; Shunsuke Minakuchi
  Gerodontology, 42, 3, 416, 428, 19 Mar. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, OBJECTIVE: To date, no studies have directly investigated the association between oral health management (OHM) and food forms. Therefore, this study aimed to investigate the association between OHM by dental hygienists and food forms in older adults admitted to long-term care facilities (LTCFs). BACKGROUND: OHM involves oral health maintenance by dental hygienists and may prevent weight loss and pneumonia in older adults admitted to LTCFs. MATERIALS AND METHODS: Older adults in LTCFs in Japan (n = 273) who participated in baseline (2018) and follow-up (2019) surveys were evaluated. Basic characteristics, medical history, OHM status, oral maintenance management status, food forms, and oral conditions were investigated at baseline. After 1 year, a follow-up survey was conducted only on food items. Furthermore, factors associated with the maintenance or improvement in food forms after 1 year were examined using binomial logistic regression analysis. RESULTS: Overall, 273 (69.2%) older adults in LTCFs required OHM by dental hygienists during the follow-up year, of whom 142 (52.0%) received OHM and 88 maintained or improved their regular diet. The analyses revealed that the maintenance or improvement in food forms after 1 year was significantly associated with OHM implementation (odds ratio: 2.01, 95% confidence interval: 1.03-3.90). CONCLUSION: OHM in older adults in Japanese LTCFs was associated with the maintenance or improvement in food forms, emphasising the importance of OHM for these individuals. OHM may also maintain or improve eating and swallowing functions, improving nutritional status.
• Response to the Letter to the Editor, "Is oral frailty a cause or a consequence?".
  Masanori Iwasaki; Maki Shirobe; Keiko Motokawa; Tomoki Tanaka; Kazunori Ikebe; Takayuki Ueda; Shunsuke Minakuchi; Masahiro Akishita; Hidenori Arai; Katsuya Iijima; Hiroyuki Sasai; Shuichi Obuchi; Hirohiko Hirano
  Geriatrics & gerontology international, 25, 4, 640, 641, 19 Feb. 2025, [Domestic magazines]
  English
• Association Between Dietary Variety and Masticatory Behaviors Measured Using Wearable Device Among Community-Dwelling Older Adults in Japan: A Multilevel Meal-by-Meal Analysis.
  Kana Eguchi; Maki Shirobe; Masanori Iwasaki; Keiko Motokawa; Tatsunosuke Gomi; Lena Kalantar; Misato Hayakawa; Ayako Edahiro; Hiroyuki Sasai; Shuichi Awata; Hirohiko Hirano
  Nutrients, 17, 4, 15 Feb. 2025, [International Magazine]
  English, Scientific journal, Background: Consuming a variety of foods is believed to promote thorough chewing; however, it remains unclear whether individuals who consume various foods actually chew them thoroughly. Therefore, this study aimed to examine the association between dietary variety and masticatory behaviors, measured using wearable devices, among community-dwelling older adults. Methods: Participants were from the Itabashi Longitudinal Study of Aging, meeting the eligibility criteria, including the ability to exchange messages via smartphone or computer. Masticatory behaviors (number of chews, chewing duration, and speed) and meal photo data were objectively measured using an ear-worn bite sensor and its application for two or three meals per day for at least three days at home. The "modified Dietary Variety Score (m-DVS)" (range 0-10, with higher values indicating greater dietary variety) was calculated by registered dietitians. Generalized linear mixed models assessed the association between m-DVS as the exposure variable and masticatory behaviors as the outcome variable. Covariates included sociodemographic status, health behavior, health status, oral health, and oral function. Results: Five hundred and eighty-seven mealtime data entries from 63 participants were included in the analysis. The m-DVS was significantly positively associated with the number of chews (cycles, unstandardized regression coefficient = 116.5, 95% confidence interval [CI] = 85.2 to 147.8) and chewing duration (min, unstandardized regression coefficient = 1.7, 95% CI = 1.3 to 2.2). Conclusions: Consuming more varied food groups was associated with more chews and longer chewing duration among community-dwelling older adults, potentially promoting thorough chewing.
• Association Between Undernutrition and the Number of Molar Occlusions in Older Persons Requiring Care in Long-Term Care Insurance Facilities
  Koji Takahashi; Yutaka Watanabe; Takuma Okumura; Yasushi Tamada; Misuzu Sato; Masanori Iwasaki; Maki Shirobe; Hirohiko Hirano; Yoshihiro Kugimiya; Masako Kishima; Kayoko Ito; Yasuyuki Iwasa; Yoshihiko Watanabe; Shinsuke Mizutani; Kazuharu Nakagawa; Shigekazu Komoto; Yutaka Yamazaki
  Nutrients, 17, 4, 10 Feb. 2025, [International Magazine]
  English, Scientific journal, Background/Objectives: Undernutrition increases the mortality risk in older persons requiring long-term care; further, it is associated with oral functions such as swallowing and chewing. Moreover, occlusion affects oral function and is crucially involved in nutritional intake. The present study aimed to examine the association between the number of molar occlusions and undernutrition according to body mass index (BMI) in older persons requiring long-term care. Methods: Japanese older persons requiring long-term care were categorized based on BMI (<20 kg/m2 vs. 20 kg/m2). We examined the association between undernutrition and the number of molar occlusions (one in each of the left and right premolars and molars, for a total of four). Results: Among 893 included participants, 440 (49.3%) had BMI < 20 kg/m2 and 453 (50.7%) had BMI > 20 kg/m2. Binomial logistic regression analysis revealed that BMI < 20 kg/m2 was significantly associated with increased number of molar occlusions (odds ratio: 0.52-0.70, 95% CI: 0.28-1.00). This indicated that a decrease in the number of molar occlusions was associated with malnutrition as determined through BMI in older persons requiring long-term care and residing in long-term care insurance facilities in Japan. Conclusions: Our findings suggest that maintaining occlusal support may help maintain nutritional status in older persons requiring long-term care.
• Association between oral health-related quality of life and physical frailty among community-dwelling older adults: A 2-year longitudinal study.
  Satoko Kakuta; Masanori Iwasaki; Yumi Kimura; Takatoshi Hiroshimaya; Ji-Woo Park; Taizo Wada; Yasuko Ishimoto; Michiko Fujisawa; Kiyohito Okumiya; Kozo Matsubayashi; Ryuji Hosokawa; Hiroshi Ogawa; Ryota Sakamoto; Toshihiro Ansai
  The Journal of frailty & aging, 14, 1, 100008, 100008, Feb. 2025, [International Magazine]
  English, Scientific journal, BACKGROUND: Frailty is a major health concern among older adults, and its association with oral health-related quality of life (OHRQoL) remains underexplored in longitudinal studies. OBJECTIVE: To investigate the association between baseline OHRQoL and physical frailty incidence at a 2-year follow-up in community-dwelling older adults. DESIGN: Prospective longitudinal study. SETTING: The study was conducted within the Tosa Longitudinal Aging Study framework in Japan. PARTICIPANTS: This study included 144 community-dwelling older adults (50 men and 94 women; median age, 81.0 years) with complete data who participated in the Tosa Longitudinal Aging Study in 2016 and 2018 and were not categorized as physical frailty in 2016. MEASUREMENTS: Baseline assessment included OHRQoL, which was evaluated using the General Oral Health Assessment Index (GOHAI; range 12-60), with higher scores indicating better OHRQoL, oral function, and general health status. The incidence of physical frailty was defined using the revised Japanese version of the Cardiovascular Health Study criteria. The association between the GOHAI score and physical frailty was assessed using logistic regression analysis. RESULTS: The median baseline GOHAI score was 58. The incidence of frailty after a 2-year follow-up was 13.9 % among the participants (18.0 and 11.7 % for men and women, respectively). Each point of the GOHAI score was associated with an 11 % reduction in frailty risk over 2 years after adjusting by age, sex, number of teeth, Food Diversity Score, Geriatric Depression Scale score, eating alone, smoking, and more than five medications (adjusted odds ratio: 0.893; 95 % confidence interval: 0.810-0.984). CONCLUSIONS: This longitudinal study showed that a higher baseline OHRQoL, based on the GOHAI score, was linked to a lower incidence of physical frailty among community-dwelling older adults after 2 years.
• [Cross-sectional study of factors related to declining participation in community gathering places providing communal meals: A social marketing framework].
  Tatsunosuke Gomi; Keiko Motokawa; Maki Shirobe; Masanori Iwasaki; Ayako Edahiro; Shuichi Obuchi; Yoshinori Fujiwara; Hidenori Arai; Shuichi Awata; Hirohiko Hirano
  [Nihon koshu eisei zasshi] Japanese journal of public health, 72, 1, 22, 31, 30 Jan. 2025, [Domestic magazines]
  Japanese, Scientific journal, Objectives While Community gathering places known as "kayoi-no-ba" providing communal meals play a crucial role in promoting the health of older adults, the researches supporting their operations and maintenance is limited. Social marketing has been successful in implementing strategic public health programs. This study aimed to identify factors associated with declining participation in kayoi-no-ba providing communal meals using a social marketing framework based on the 4Ps marketing mix (product, promotion, place, and price).Methods In November 2019, this cross-sectional study surveyed kayoi-no-ba providing communal meals nationwide via a mail. A total of 580 kayoi-no-ba organizers with complete data participated. Changes in the number of participants were assessed using a questionnaire in order to determine the decrease since their establishment. Survey items were organized based on the 4Ps marketing mix framework and treated as independent variables. Multivariate Poisson regression analysis was conducted with participant decrease as the dependent variable, and prevalence ratios (PR) were calculated. The opening period and the number of participants at the time of the survey were included as covariates.Results A total of 154 kayoi-no-ba experienced the decline in participants (26.6%). Multivariate analysis revealed the following. For product variables, a high frequency of monthly events was significantly associated with a lower PR for participant decrease (0.92). Among promotion variables, kayoi-no-ba with a registration system had a significantly higher PR for participant decrease (1.49). For place variables, a higher population density in the region was significantly associated with a lower PR (0.90), whereas a higher ratio of the population aged 65 years and older was significantly associated with a higher PR (1.05). The price variables did not show a significant association with the decrease in participants.Conclusions Except price, the other three marketing 4Ps were significantly associated with decreases in participants at kayoi-no-ba providing communal meals. Future efforts should focus on developing and evaluating kayoi-no-ba strategies to ensure sustained participant engagement and promote the health of older adults through communal meals.
• Association between Oral Function and Masticatory Behaviors Measured Using a Wearable Device in Community-dwelling Older Adults：A Preliminary Study
  Eguchi Kana; Motokawa Keiko; Iwasaki Masanori; Shirobe Maki; Gomi Tatsunosuke; Kalantar Lena; Hayakawa Misato; Edahiro Ayako; Inagaki Hiroki; Sasai Hiroyuki; Awata Shuichi; Hirano Hirohiko
  Ronen Shika Igaku, 40, 1, 54, 64, Japanese Society of Gerodontology, 2025
  Japanese, Purpose：Differences in masticatory behaviors, such as number of chews and chewing speed, according to the status of oral function could be useful for the early detection of oral functional decline. To clarify the masticatory behaviors of community-dwelling older adults with slight oral functional decline, we examined the association between oral function and masticatory behaviors using the wearable bitescan^®（BS）device.
  
  
  Methods：Participants who met the inclusion criteria, such as the ability to communicate via smartphone, were recruited from the Itabashi Longitudinal Study on Aging. Based on oral function measurements, participants without any of the seven diagnostic criteria for oral hypofunction were categorized into the robust group, whereas those who met one or two diagnostic criteria were categorized into the pre-decline group. The outcome variables were masticatory behaviors（number of chews, chewing speed, number of chews per bite［average and maximum］, food intake, and chewing time）during consumption of the standardized test food measured using BS. The exposure variable was oral function（dichotomous：robust or pre-decline）. The covariates were sex, age, body mass index, educational status, and Charlson Comorbidity Index. A multiple linear regression analysis was conducted.
  
  
  Results：A total of 35 participants（mean±standard deviation age, 74.2±3.2 years）were included. Of these, 12 were women, and 30 were included in the pre-decline group. Multiple linear regression analysis showed that a slight decline in oral function was significantly associated with a lower number of chews（cycles［unstandardized regression coefficient］（B）, －79.32；95% confidence interval［CI］, －134.65, －23.99）, slower chewing speed（cycles/minute［B］, －0.01；95% CI, －0.16, －0.04）, a lower average number of chews per bite（cycles［B］, －0.41；95% CI, －0.77, －0.06）, and a reduced maximum number of chews per bite（B, －0.38；95% CI, －0.67, －0.10）.
  
  
  Conclusion：Community-dwelling older adults with slight oral functional decline had slower chewing speeds and fewer number of chews.
• [Cross-sectional association between social isolation and nutritional status among older urban adults: The Itabashi Longitudinal Study on Aging].
  Lena Käläntär; Tatsunosuke Gomi; Keiko Motokawa; Misato Hayakawa; Yurie Mikami; Maki Shirobe; Masanori Iwasaki; Narumi Kojima; Yosuke Osuka; Hiroyuki Sasai; Hiroki Inagaki; Fumiko Miyamae; Ayako Edahiro; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata
  Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 62, 1, 70, 77, 2025, [Domestic magazines]
  Japanese, Scientific journal, AIM: The social isolation of older Japanese adults with infrequent contact with others diminishes appetite, reduces food intake, and worsens their nutritional status. However, there is insufficient evidence regarding the association between social isolation and nutritional status, with studies primarily confined to rural and suburban areas. This cross-sectional study aimed to investigate the association between social isolation and nutritional status among older adults residing in urban areas. METHODS: This cross-sectional analysis included 1,052 adults (mean age, 78 years). Nutritional status was assessed using the Mini Nutritional Assessment® Short Form, with a score of 11 or below indicating malnutrition. Applying the abbreviated Lubben Social Network Scale, a score < 12 was considered indicative of social isolation. Logistic regression was applied to the entire population, then the population was separated by sex, with social isolation as the independent variable and malnutrition as the dependent variable. The covariates included age, living alone, economic status, health, daily activities, smoking habits, drinking habits, and years of education. RESULTS: Social isolation was observed in 41.7% (n = 439) of the total population, while malnutrition was observed in 27.4% (n = 288). Social isolation was significantly associated with malnutrition (odds ratio: 1.41, 95% confidence interval: 1.06-1.88). Sex subgroup analyses revealed that a significant association was retained only among female participants. CONCLUSIONS: Social isolation has been associated with malnutrition among older urban adults in Japan. Future longitudinal studies of the nutritional status of socially isolated individuals are essential.
• Oral frailty and its association with systemic health: A narrative review
  Yutaka Watanabe; Nami Matsuda; Kazuhito Miura; Yuki Ohara; Masanori Iwasaki; Hirohiko Hirano; Kazunori Ikebe; Katsuya Iijima; Yukari Kono; Yutaka Yamazaki
  Oral Science International, Jan. 2025, [Peer-reviewed]
  Scientific journal
• 口腔機能低下症の現在地 2023年度 口腔機能低下症ワーキンググループ成果報告
  池邉 一典; 岩崎 正則; 上田 貴之; 平野 浩彦; 古屋 純一; 高橋 利士; 水口 俊介
  老年歯科医学, 39, 3, 178, 181, (一社)日本老年歯科医学会, Dec. 2024
  Japanese
• Predictive Factors for Swallowing Function Decline in Older Adults With Alzheimer's Disease: A 1-Year Longitudinal Study.
  Maki Shirobe; Ayako Edahiro; Keiko Motokawa; Shiho Morishita; Yuki Ohara; Yutaka Watanabe; Masanori Iwasaki; Hirohiko Hirano
  Journal of oral rehabilitation, 52, 3, 375, 383, 26 Nov. 2024, [International Magazine]
  English, Scientific journal, BACKGROUND: By 2060, the global burden of dementia, particularly Alzheimer's disease (AD), is expected to increase significantly, necessitating effective palliative care strategies. Dysphagia, a common condition among people with dementia, leads to malnutrition, aspiration pneumonia, and a reduced quality of life. OBJECTIVE: This study aimed to identify oral health management factors that could predict a decline in swallowing function in older adults with AD. METHODS: Data from the Akita-Omorimachi study, which included 63 adults diagnosed with AD, were analysed. Swallowing function was assessed using the modified water-swallowing test (MWST) at baseline and after 1 year. RESULTS: The results indicated that 25.4% of participants exhibited a decline in swallowing function, as indicated by a decrease from the highest MWST score of 5 at baseline to a lower score at follow-up. Poisson regression analysis revealed that refusal of oral care (incidence rate ratio (IRR): 7.28), tongue coating (IRR: 4.21), and unclear articulation of /ka/ (IRR: 5.79) were significant predictors of swallowing function decline. The participants with these indicators had a higher risk of developing dysphagia. CONCLUSIONS: These findings suggest that factors related to specific oral health problems may predict poor swallowing function in older adults with AD. Moreover, implementing targeted oral care interventions, including person-centered care and regular tongue cleaning, may improve the outcomes in this vulnerable population. Despite the limitations of this study, including a small sample size, the results underscore the importance of comprehensive oral health management in preventing dysphagia-related complications.
• Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants
  Bin Zhou; Archie W Rayner; Edward W Gregg; Kate E Sheffer; Rodrigo M Carrillo-Larco; James E Bennett; Jonathan E Shaw; Christopher J Paciorek; Rosie K Singleton; Ana Barradas Pires; Gretchen A Stevens; Goodarz Danaei; Victor PF Lhoste; Nowell H Phelps; Rachel A Heap; Lakshya Jain; Yse D'Ailhaud De Brisis; Agnese Galeazzi; Andre P Kengne; Anu Mishra; Nayu Ikeda; Hsien-Ho Lin; Carlos A Aguilar-Salinas; Ranjit Mohan Anjana; Habiba Ben Romdhane; Kairat Davletov; Shubash Ganapathy; Christin Heidemann; Yousef Saleh Khader; Young-Ho Khang; Avula Laxmaiah; Jean Claude N Mbanya; Viswanathan Mohan; KM Venkat Narayan; Meda E Pavkov; Eugène Sobngwi; Alisha N Wade; Novie O Younger-Coleman; Tomasz Zdrojewski; Leandra Abarca-Gómez; Mohsen Abbasi-Kangevari; Hanan F Abdul Rahim; Niveen M Abu-Rmeileh; Shalkar Adambekov; Robert J Adams; Wichai Aekplakorn; Shoaib Afzal; Imelda A Agdeppa; Javad Aghazadeh-Attari; Charles Agyemang; Noor Ani Ahmad; Ali Ahmadi; Naser Ahmadi; Nastaran Ahmadi; Soheir H Ahmed; Wolfgang Ahrens; Kamel Ajlouni; Sarah F Al-Hamli; Halima Al-Hinai; Jawad A Al-Lawati; Deena Al Asfoor; Monira Alarouj; Fadia AlBuhairan; Shahla AlDhukair; Mohamed M Ali; Mohammed K Ali; Anna V Alieva; Farbod Alinezhad; Abdullah Alkandari; Ala'a Alkerwi; Eman Aly; Deepak N Amarapurkar; Lars Bo Andersen; Sigmund A Anderssen; Dolores S Andrade; Alireza Ansari-Moghaddam; Hajer Aounallah-Skhiri; Joana Araújo; Tahir Aris; Raphael E Arku; Nimmathota Arlappa; Krishna K Aryal; Thor Aspelund; Felix K Assah; Batyrbek Assembekov; Shiu Lun Au Yeung; Juha Auvinen; Mária Avdičová; Kishwar Azad; Ana Azevedo; Mohsen Azimi-Nezhad; Fereidoun Azizi; Flora Bacopoulou; Nagalla Balakrishna; Yulia Balanova; Mohamed Bamoshmoosh; Maciej Banach; Piotr Bandosz; José R Banegas; Carlo M Barbagallo; Alberto Barcelo; Maja Baretić; Lena Barrera; Marta Barreto; Abdul Basit; Anwar M Batieha; Aline P Batista; Louise A Baur; Antonisamy Belavendra; Theodora Benedek; Mikhail Benet; Michaela Benzeval; Salim Berkinbayev; Antonio Bernabe-Ortiz; Ximena Berrios Carrasola; Heloísa Bettiol; Augustin F Beybey; Santosh K Bhargava; Yufang Bi; Elysée Claude Bika Lele; Mukharram M Bikbov; Bihungum Bista; Peter Bjerregaard; Espen Bjertness; Marius B Bjertness; Cecilia Björkelund; Katia V Bloch; Anneke Blokstra; Martin Bobak; Bernhard O Boehm; Jose G Boggia; Carlos P Boissonnet; Stig E Bojesen; Marialaura Bonaccio; Alice Bonilla-Vargas; Herman Borghs; Steve Botomba; Pascal Bovet; Imperia Brajkovich; Hermann Brenner; Lizzy M Brewster; Garry R Brian; Yajaira Briceño; Miguel Brito; Gloria Bueno; Anna Bugge; Frank Buntinx; Antonio Cabrera de León; Roberta B Caixeta; Günay Can; Ana Paula C Cândido; Mario V Capanzana; Naděžda Čapková; Eduardo Capuano; Rocco Capuano; Vincenzo Capuano; Viviane C Cardoso; Axel C Carlsson; Felipe F Casanueva; Laura Censi; Marvin Cervantes–Loaiza; Charalambos A Chadjigeorgiou; Parinya Chamnan; Snehalatha Chamukuttan; Queenie Chan; Fadi J Charchar; Nish Chaturvedi; Chien-Jen Chen; Huashuai Chen; Long-Sheng Chen; Ching-Yu Cheng; Bahman Cheraghian; Angela Chetrit; Shu-Ti Chiou; María-Dolores Chirlaque; Jerzy Chudek; Renata Cifkova; Massimo Cirillo; Frank Claessens; Janine Clarke; Emmanuel Cohen; Hans Concin; Cyrus Cooper; Cojocaru R Cosmin; Simona Costanzo; Melanie J Cowan; Chris Cowell; Amelia C Crampin; Ana B Crujeiras; Juan J Cruz; Felipe V Cureau; Sarah Cuschieri; Graziella D'Arrigo; Eleonora d'Orsi; Haroldo da Silva-Ferreira; Jean Dallongeville; Albertino Damasceno; Rachel Dankner; Saeed Dastgiri; Luc Dauchet; Amalia De Curtis; Giovanni de Gaetano; Stefaan De Henauw; David De Ridder; Mohan Deepa; Vincent Jr DeGennaro; Stefaan Demarest; Elaine Dennison; Valérie Deschamps; Meghnath Dhimal; Zivka Dika; Shirin Djalalinia; Chiara Donfrancesco; Maria Dorobantu; Nico Dragano; Wojciech Drygas; Shufa Du; Yong Du; Charmaine A Duante; Priscilla Duboz; Rosemary B Duda; Anar Dushpanova; Vilnis Dzerve; Elzbieta Dziankowska-Zaborszczyk; Narges Ebrahimi; Ricky Eddie; Ebrahim Eftekhar; Vasiliki Efthymiou; Eruke E Egbagbe; Robert Eggertsen; Sareh Eghtesad; Clara Ladi Ejembi; Mohammad El-Khateeb; Jalila El Ati; Denise Eldemire-Shearer; Roberto Elosua; Ofem Enang; Rajiv T Erasmus; Cihangir Erem; Gul Ergor; Louise Eriksen; Johan G Eriksson; Ali Esmaeili; Roger G Evans; Guy Fagherazzi; Noushin Fahimfar; Ildar Fakhradiyev; Albina A Fakhretdinova; Caroline H Fall; Elnaz Faramarzi; Mojtaba Farjam; Farshad Farzadfar; Yosef Farzi; Mohammad Reza Fattahi; Asher Fawwad; Francisco J Felix-Redondo; Trevor S Ferguson; Daniel Fernández-Bergés; Desha R Fernando; Thomas Ferrao; Marika Ferrari; Marco M Ferrario; Catterina Ferreccio; Eldridge Ferrer; Edith JM Feskens; Günther Fink; David Flood; Maria Forsner; Sandrine Fosse-Edorh; Edward F Fottrell; Heba M Fouad; Damian K Francis; Guillermo Frontera; Isti I Fujiati; Matsuda Fumihiko; Takuro Furusawa; Zbigniew Gaciong; Fabio Galvano; Sarah P Garnett; Jean-Michel Gaspoz; Magda Gasull; Andrea Gazzinelli; Ulrike Gehring; Ebrahim Ghaderi; Seyyed-Hadi Ghamari; Ali Ghanbari; Erfan Ghasemi; Oana-Florentina Gheorghe-Fronea; Anup Ghimire; Alessandro Gialluisi; Simona Giampaoli; Francesco Gianfagna; Tiffany K Gill; Jonathan Giovannelli; Glen Gironella; Aleksander Giwercman; Marcel Goldberg; David Goltzman; Aleksandra Gomula; Helen Gonçalves; Mauer Gonçalves; David A Gonzalez-Chica; Marcela Gonzalez-Gross; Juan P González-Rivas; Angel R Gonzalez; Atsushi Goto; Frederic Gottrand; Dušan Grafnetter; Maria G Grammatikopoulou; Andriene Grant; Anne Sameline Grimsgaard; Tomasz Grodzicki; Anders Grøntved; Giuseppe Grosso; Dongfeng Gu; Vilmundur Gudnason; Ramiro Guerrero; Idris Guessous; Unjali P Gujral; Rajeev Gupta; Laura Gutierrez; Xinyi Gwee; Seongjun Ha; Rosa Haghshenas; Hamid Hakimi; Ian R Hambleton; Behrooz Hamzeh; Dominique Hange; Sari Hantunen; Jie Hao; Javad Harooni; Seyed Mohammad Hashemi-Shahri; Jun Hata; Alison J Hayes; Jiang He; Rafael dos Santos Henrique; Ana Henriques; Sauli Herrala; Karl-Heinz Herzig; Ramin Heshmat; Allan G Hill; Sai Yin Ho; Michelle Holdsworth; Reza Homayounfar; Wilma M Hopman; Andrea RVR Horimoto; Claudia Hormiga; Bernardo L Horta; Leila Houti; Christina Howitt; Thein Thein Htay; Aung Soe Htet; Maung Maung Than Htike; José María Huerta; Ilpo Tapani Huhtaniemi; Laetitia Huiart; Martijn Huisman; Monica Hunsberger; Abdullatif Husseini; Inge Huybrechts; Licia Iacoviello; Ellina M Iakupova; Anna G Iannone; Norazizah Ibrahim Wong; Chinwuba Ijoma; Vilma E Irazola; Takafumi Ishida; Sheikh Mohammed Shariful Islam; Duygu Islek; Till Ittermann; Masanori Iwasaki; Tuija Jääskeläinen; Jeremy M Jacobs; Hashem Y Jaddou; Michel Jadoul; Bakary Jallow; Kenneth James; Kazi M Jamil; Edward Janus; Marjo-Riitta Jarvelin; Grazyna Jasienska; Ana Jelaković; Bojan Jelaković; Garry Jennings; Anjani Kumar Jha; AM Jibo; Ramon O Jimenez; Karl-Heinz Jöckel; Jari J Jokelainen; Jost B Jonas; Josipa Josipović; Farahnaz Joukar; Jacek Jóźwiak; Anthony Kafatos; Eero O Kajantie; Zhanna Kalmatayeva; Ofra Kalter-Leibovici; Argyro Karakosta; Khem B Karki; Marzieh Katibeh; Prasad Katulanda; Jussi Kauhanen; Gyulli M Kazakbaeva; François F Kaze; Calvin Ke; Sirkka Keinänen-Kiukaanniemi; Roya Kelishadi; Maryam Keramati; Mathilde Kersting; Kazem Khalagi; Arsalan Khaledifar; Davood Khalili; Bahareh Kheiri; Motahareh Kheradmand; Alireza Khosravi Farsani; Ursula Kiechl-Kohlendorfer; Sophia J Kiechl; Stefan Kiechl; Hyeon Chang Kim; Andrew Kingston; Heidi Klakk; Jana Klanova; Michael Knoflach; Patrick Kolsteren; Jürgen König; Raija Korpelainen; Paul Korrovits; Jelena Kos; Seppo Koskinen; Sudhir Kowlessur; Slawomir Koziel; Wolfgang Kratzer; Susi Kriemler; Peter Lund Kristensen; Steinar Krokstad; Daan Kromhout; Ruzena Kubinova; Urho M Kujala; Mukhtar Kulimbet; Vaitheeswaran Kulothungan; Meena Kumari; Vladimir Kutsenko; Catherine Kyobutungi; Quang Ngoc La; Tiina Laatikainen; Demetre Labadarios; Carl Lachat; Youcef Laid; Lachmie Lall; Anne Langsted; Tiina Lankila; Vera Lanska; Georg Lappas; Bagher Larijani; Tint Swe Latt; Martino Laurenzi; Gwenaëlle Le Coroller; Jeannette Lee; Terho Lehtimäki; Daniel Lemogoum; Gabriel M Leung; Charlie Lim; Wei-Yen Lim; M Fernanda Lima-Costa; Yi-Jing Lin; Lars Lind; Lauren Lissner; Liping Liu; Xiaotian Liu; Wei-Cheng Lo; Helle-Mai Loit; Esther Lopez-Garcia; Tania Lopez; José Eugenio Lozano; Dalia Luksiene; Annamari Lundqvist; Nuno Lunet; Thomas Lung; Michala Lustigová; Guansheng Ma; George LL Machado-Coelho; Aristides M Machado-Rodrigues; Enguerran Macia; Luisa M Macieira; Ahmed A Madar; Gladys E Maestre; Stefania Maggi; Dianna J Magliano; Emmanuella Magriplis; Gowri Mahasampath; Bernard Maire; Marcia Makdisse; Konstantinos Makrilakis; Mohammad-Reza Malekpour; Fatemeh Malekzadeh; Reza Malekzadeh; Sofia Malyutina; Lynell V Maniego; Yannis Manios; Fariborz Mansour-Ghanaei; Enzo Manzato; Mala Ali Mapatano; Anie Marcil; Francisco Mardones; Paula Margozzini; Pedro Marques-Vidal; Larissa Pruner Marques; Reynaldo Martorell; Luis P Mascarenhas; Mannix Masimango Imani; Masoud Masinaei; Shariq R Masoodi; Ellisiv B Mathiesen; Prashant Mathur; Tandi E Matsha; Anselmo J Mc Donald Posso; Shelly R McFarlane; Stephen T McGarvey; Scott B McLean; Breige A McNulty; Sounnia Mediene Benchekor; Kirsten Mehlig; Amir Houshang Mehrparvar; Jesus D Melgarejo; Fabián Méndez; Ana Maria B Menezes; Alibek Mereke; Indrapal I Meshram; Diane T Meto; Nathalie Michels; Cláudia S Minderico; GK Mini; Juan Francisco Miquel; J Jaime Miranda; Mohammad Reza Mirjalili; Daphne Mirkopoulou; Pietro A Modesti; Sahar Saeedi Moghaddam; Kazem Mohammad; Mohammad Reza Mohammadi; Zahra Mohammadi; Noushin Mohammadifard; Reza Mohammadpourhodki; Muhammad Fadhli Mohd Yusoff; Iraj Mohebbi; Niels C Møller; Dénes Molnár; Amirabbas Momenan; Roger A Montenegro Mendoza; Mahmood Moosazadeh; Farhad Moradpour; Alain Morejon; Luis A Moreno; Karen Morgan; Suzanne N Morin; George Moschonis; Alireza Moslem; Mildrey Mosquera; Malgorzata Mossakowska; Aya Mostafa; Seyed-Ali Mostafavi; Eugen Mota; Jorge Mota; Maria Mota; Mohammad Esmaeel Motlagh; Jorge Motta; Kelias P Msyamboza; Thet Thet Mu; Maria L Muiesan; Patricia B Munroe; Jaakko Mursu; Kamarul Imran Musa; Norlaila Mustafa; Muel Telo MC Muyer; Iraj Nabipour; Gabriele Nagel; Balkish M Naidu; Farid Najafi; Jana Námešná; Ei Ei K Nang; Vinay B Nangia; Take Naseri; Ana J Navarro-Ramírez; Nareemarn Neelapaichit; Azim Nejatizadeh; Ilona Nenko; Flavio Nervi; Tze Pin Ng; Chung T Nguyen; Nguyen D Nguyen; Quang Ngoc Nguyen; Michael Y Ni; Peng Nie; Ramfis E Nieto-Martínez; Guang Ning; Toshiharu Ninomiya; Nobuo Nishi; Marianna Noale; Oscar A Noboa; Mitsuhiko Noda; Børge G Nordestgaard; Davide Noto; Mohannad Al Nsour; Irfan Nuhoğlu; Moffat Nyirenda; Terence W O'Neill; Kyungwon Oh; Ryutaro Ohtsuka; Mohd Azahadi Omar; Altan Onat; Sok King Ong; Obinna Onodugo; Pedro Ordunez; Rui Ornelas; Pedro J Ortiz; Clive Osmond; Afshin Ostovar; Johanna A Otero; Charlotte B Ottendahl; Akaninyene Otu; Ellis Owusu-Dabo; Elena Pahomova; Luigi Palmieri; Wen-Harn Pan; Demosthenes Panagiotakos; Songhomitra Panda-Jonas; Zengchang Pang; Francesco Panza; Mariela Paoli; Suyeon Park; Mahboubeh Parsaeian; Chona F Patalen; Nikhil D Patel; Raimund Pechlaner; Ivan Pećin; João M Pedro; Sergio Viana Peixoto; Markku Peltonen; Alexandre C Pereira; Thaliane Mayara Pessôa dos Prazeres; Niloofar Peykari; Modou Cheyassin Phall; Son Thai Pham; Rafael N Pichardo; Iris Pigeot; Hynek Pikhart; Aida Pilav; Pavel Piler; Freda Pitakaka; Aleksandra Piwonska; Andreia N Pizarro; Pedro Plans-Rubió; Silvia Plata; Barry M Popkin; Miquel Porta; Anil Poudyal; Farhad Pourfarzi; Akram Pourshams; Hossein Poustchi; Dorairaj Prabhakaran; Rajendra Pradeepa; Alison J Price; Jacqueline F Price; Rui Providencia; Jardena J Puder; Soile Puhakka; Margus Punab; Qing Qiao; Mostafa Qorbani; Hedley K Quintana; Tran Quoc Bao; Ricardas Radisauskas; Salar Rahimikazerooni; Olli Raitakari; Ambady Ramachandran; Manuel Ramirez-Zea; Jacqueline Ramke; Elisabete Ramos; Rafel Ramos; Lekhraj Rampal; Sanjay Rampal; Sheena E Ramsay; Daniel A Rangel Reina; Ravindra P Rannan-Eliya; Mohammad-Mahdi Rashidi; Josep Redon; Jane DP Renner; Cézane P Reuter; Luis Revilla; Negar Rezaei; Abbas Rezaianzadeh; Yeunsook Rho; Fernando Rigo; Leanne M Riley; Ulf Risérus; Reina G Roa; Louise Robinson; Wendy E Rodríguez-Anderson; Fernando Rodríguez-Artalejo; María del Cristo Rodriguez-Perez; Laura A Rodríguez-Villamizar; Andrea Y Rodríguez; Ulla Roggenbuck; Peter Rohloff; Rosalba Rojas-Martinez; Elisabetta L Romeo; Annika Rosengren; Joel GR Roy; Adolfo Rubinstein; Maria Ruiz-Castell; Paola Russo; Petra Rust; Marcin Rutkowski; Charumathi Sabanayagam; Hamideh Sabbaghi; Harshpal S Sachdev; Alireza Sadjadi; Ali Reza Safarpour; Sare Safi; Saeid Safiri; Mohammad Hossien Saghi; Olfa Saidi; Satoko Sakata; Nader Saki; Sanja Šalaj; Benoit Salanave; Jukka T Salonen; Massimo Salvetti; Jose Sánchez-Abanto; Diana A Santos; Lèlita C Santos; Maria Paula Santos; Rute Santos; Tamara R Santos; Jouko L Saramies; Luis B Sardinha; Nizal Sarrafzadegan; Yoko Sato; Kai-Uwe Saum; Stefan Savin; Norie Sawada; Mariana Sbaraini; Marcia Scazufca; Beatriz D Schaan; Herman Schargrodsky; Christa Scheidt-Nave; Sabine Schipf; Amand Floriaan Schmidt; Börge Schmidt; Carsten O Schmidt; Peter Schnohr; Catherine Mary Schooling; Ben Schöttker; Sara Schramm; Sylvain Sebert; Moslem Sedaghattalab; Aye Aye Sein; Abhijit Sen; Sadaf G Sepanlou; Jennifer Servais; Ronel Sewpaul; Svetlana Shalnova; Seyed Morteza Shamshirgaran; Coimbatore Subramaniam Shanthirani; Maryam Sharafkhah; Sanjib K Sharma; Almaz Sharman; Amaneh Shayanrad; Ali Akbar Shayesteh; Kenji Shibuya; Hana Shimizu-Furusawa; Rahman Shiri; Marat Shoranov; Namuna Shrestha; Khairil Si-Ramlee; Alfonso Siani; Mark J Siedner; Diego Augusto Santos Silva; Xueling Sim; Mary Simon; Judith Simons; Leon A Simons; Michael Sjöström; Jolanta Slowikowska-Hilczer; Przemysław Slusarczyk; Liam Smeeth; Stefan Söderberg; Agustinus Soemantri; Vincenzo Solfrizzi; Mohammad Hossein Somi; Aïcha Soumaré; Alfonso Sousa-Poza; Mafalda Sousa-Uva; Karen Sparrenberger; Jan A Staessen; Andreas Stang; Bill Stavreski; Jostein Steene-Johannessen; Peter Stehle; Aryeh D Stein; Jochanan Stessman; Jakub Stokwiszewski; Karien Stronks; Milton F Suarez-Ortegón; Phalakorn Suebsamran; Machi Suka; Chien-An Sun; Jianping Sun; Johan Sundström; Paibul Suriyawongpaisal; René Charles Sylva; E Shyong Tai; Furusawa Takuro; Abdonas Tamosiunas; Eng Joo Tan; Baimakhan Tanabayev; Nikhil Tandon; Mohammed Rasoul Tarawneh; Carolina B Tarqui-Mamani; Anne Taylor; Tania Tello; Yih Chung Tham; KR Thankappan; Holger Theobald; Xenophon Theodoridis; Nihal Thomas; Amanda G Thrift; Erik J Timmermans; Hanna K Tolonen; Janne S Tolstrup; Maciej Tomaszewski; Murat Topbas; Michael J Tornaritis; Maties Torrent; Laura Torres-Collado; Giota Touloumi; Pierre Traissac; Areti Triantafyllou; Oanh TH Trinh; Yu-Hsiang Tsao; Thomas Tsiampalis; Shoichiro Tsugane; John Tuitele; Azaliia M Tuliakova; Marshall K Tulloch-Reid; Tomi-Pekka Tuomainen; Maria L Turley; Evangelia Tzala; Christophe Tzourio; Peter Ueda; Eunice Ugel; Flora AM Ukoli; Hanno Ulmer; Hannu MT Uusitalo; Gonzalo Valdivia; Damaskini Valvi; Rob M van Dam; Bert-Jan van den Born; Johan Van der Heyden; Hoang Van Minh; Lenie van Rossem; Natasja M Van Schoor; Irene GM van Valkengoed; Dirk Vanderschueren; Diego Vanuzzo; Anette Varbo; Senthil K Vasan; Tomas Vega; Toomas Veidebaum; Gustavo Velasquez-Melendez; Charlotte Verdot; Giovanni Veronesi; Roosmarijn Verstraeten; Cesar G Victora; Lucie Viet; Luis Villarroel; Jesus Vioque; Jyrki K Virtanen; Bharathi Viswanathan; Peter Vollenweider; Ari Voutilainen; Martine Vrijheid; Janette Walton; Wan Mohamad Wan Bebakar; Wan Nazaimoon Wan Mohamud; Chongjian Wang; Huijun Wang; Ningli Wang; Qian Wang; Weiqing Wang; Ya Xing Wang; Yi-Ren Wang; Ying-Wei Wang; S Goya Wannamethee; Karen Webster-Kerr; Niels Wedderkopp; Wenbin Wei; Leo D Westbury; Peter H Whincup; Kurt Widhalm; Indah S Widyahening; Andrzej Więcek; Nilmini Wijemunige; Rainford J Wilks; Karin Willeit; Peter Willeit; Tom Wilsgaard; Bogdan Wojtyniak; Roy A Wong-McClure; Andrew Wong; Emily B Wong; Mark Woodward; Chao-Chun Wu; Frederick C Wu; Haiquan Xu; Liang Xu; Yu Xu; Nor Azwany Yaacob; Li Yan; Weili Yan; Tabara Yasuharu; Chao-Yu Yeh; Moein Yoosefi; Akihiro Yoshihara; San-Lin You; Yu-Ling Yu; Ahmad Faudzi Yusoff; Ahmad A Zainuddin; Farhad Zamani; Sabina Zambon; Antonis Zampelas; Abdul Hamid Zargar; Ko Ko Zaw; Tajana Zeljkovic Vrkic; Yi Zeng; Bing Zhang; Lei Zhang; Luxia Zhang; Zhen-Yu Zhang; Ming-Hui Zhao; Wenhua Zhao; Bekbolat Zholdin; Paul Zimmet; Marie Zins; Emanuel Zitt; Nada Zoghlami; Julio Zuñiga Cisneros; Majid Ezzati
  The Lancet, Elsevier BV, Nov. 2024
  Scientific journal
• Weight Loss and Number of Present Teeth in Community-Dwelling Japanese Older Adults: A Cross-Sectional Study in Niigata.
  Sachiko Takehara; Masayuki Ueno; Akihiro Yoshihara; Masanori Iwasaki; Kana Suwama; Kumiko Minagawa; Ichiei Narita; Junta Tanaka; Hiroshi Ogawa; Yumi Ito
  Journal of oral rehabilitation, 52, 2, 169, 180, 01 Nov. 2024, [International Magazine]
  English, Scientific journal, BACKGROUND AND OBJECTIVES: Weight loss is a critical health issue among the older population. This study aimed to explore the association between weight loss and oral health in older adults. METHODS: We used cross-sectional data from the Uonuma Chronic Kidney Disease Cohort Study. The binary logistic regression models were fitted to estimate the relationship between weight loss and independent variables including the number of teeth present. RESULTS: The participants included 1656 females and 1625 males. There were 1217 females (73.4%) and 1236 males (76.0%) with normal BMI (18.5 ≤ BMI < 25) in the previous year. Weight loss was determined over a 12-month period. Individuals with normal BMI in previous year, and those with weight loss (≥ 5%) or those whom maintained a stable weight were further analysed. The regression analysis (model 3, fully adjusted) showed that females with 0 and 1-10 teeth present had a higher likelihood of losing weight (OR = 4.07; 95% CI = 1.85-8.93, OR = 2.33; 95% CI = 1.24-4.39) compared with those with 20 or more teeth. Current smokers had a higher likelihood of losing weight (OR = 3.15; 95% CI = 1.01-9.76) than lifelong abstainers. Among males, both current and previous smokers showed a higher likelihood of losing weight (OR = 4.94; 95%CI = 1.76-13.8, OR = 3.35; 95% CI = 1.29-8.68) than those who never smoked. CONCLUSIONS: This study indicates that the number of teeth and smoking are both linked to weight loss in females. However, in males, the association between the number of teeth and weight loss may be compromised due to the high prevalence of smoking in this group.
• Consensus statement on "Oral frailty" from the Japan Geriatrics Society, the Japanese Society of Gerodontology, and the Japanese Association on Sarcopenia and Frailty.
  Tomoki Tanaka; Hirohiko Hirano; Kazunori Ikebe; Takayuki Ueda; Masanori Iwasaki; Shunsuke Minakuchi; Hidenori Arai; Masahiro Akishita; Koichi Kozaki; Katsuya Iijima
  Geriatrics & gerontology international, 24, 11, 1111, 1119, 07 Oct. 2024, [Domestic magazines]
  English, Scientific journal, The concept of oral frailty was first proposed in Japan in 2014 by the "Joint Working Committee on Oral Frailty," consisting of three academic societies-the Japan Geriatrics Society, the Japanese Society of Gerodontology, and the Japanese Association on Sarcopenia and Frailty-to enhance public understanding of oral frailty. Oral frailty is a state between robust oral function (a "healthy mouth") and its decline, characterized by slight declines in oral function, including tooth loss and difficulties in eating and communicating, which increase the risk of impaired oral functional capacity but can be reversed with proper intervention and treatment. Oral frailty can be assessed using the Oral Frailty 5-item Checklist (OF-5) without the need for a dental health professional. Oral frailty is defined as having at least two of the following components: (i) fewer teeth, (ii) difficulty chewing, (iii) difficulty swallowing, (iv) dry mouth, and (v) low articulatory oral motor skills. Approximately 40% of community-dwelling older adults have oral frailty. Oral frailty is associated with poor dietary variety, social isolation, physical frailty, disability, and mortality. This statement introduces the concept and definition of oral frailty, a new assessment tool (OF-5), and concept diagrams for healthcare professionals and the general public. These tools aim to promote public awareness and facilitate collaboration between medical and dental healthcare providers. Geriatr Gerontol Int 2024; ••: ••-••.
• Is urinary taurine associated with protein intake? Itabashi Longitudinal Study on Aging.
  Keiko Motokawa; Maki Shirobe; Masanori Iwasaki; Yosuke Komatsu; Takuya Shibasaki; Yasuaki Wada; Yurie Mikami; Misato Hayakawa; Takashi Shida; Hiroyuki Sasai; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata
  Geriatrics & gerontology international, 24, 9, 987, 989, 13 Aug. 2024, [Domestic magazines]
  English
• General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants
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Peter Stehle; Aryeh D Stein; George S Stergiou; Jakub Stokwiszewski; Ekaterina Stoyanova; Gareth Stratton; Karien Stronks; Lela Sturua; Milton F Suarez-Ortegón; Phalakorn Suebsamran; Gerhard Sulo; Johan Sundström; Paibul Suriyawongpaisal; Boyd A Swinburn; René Charles Sylva; Lucjan Szponar; E Shyong Tai; Konstantinos D Tambalis; Abdonas Tamosiunas; Baimakhan Tanabayev; Maya Tanrygulyyeva; Mohammed Rasoul Tarawneh; Jakob Tarp; Carolina B Tarqui-Mamani; Radka Taxová Braunerová; Saskia Te Velde; William R Tebar; Grethe S Tell; Tania Tello; KR Thankappan; Xenophon Theodoridis; Sathish Thirunavukkarasu; Nihal Thomas; Amanda G Thrift; Ľubica Tichá; Erik J Timmermans; Dwi Hapsari Tjandrarini; Anne Tjonneland; Janne S Tolstrup; Murat Topbas; Laura Torres-Collado; Giota Touloumi; Pierre Traissac; Areti Triantafyllou; Atul Trivedi; Lechaba Tshepo; Panagiotis Tsintavis; John Tuitele; Azaliia M Tuliakova; Marshall K Tulloch-Reid; Fikru Tullu; Tomi-Pekka Tuomainen; Maria L Turley; Evangelia Tzala; Themistoklis Tzotzas; Christophe Tzourio; Peter Ueda; Eunice Ugel; Flora AM Ukoli; Zhamyila Usupova; Hannu MT Uusitalo; Nalan Uysal; Gonzalo Valdivia; Damaskini Valvi; Rob M van Dam; Bert-Jan van den Born; Johan Van der Heyden; Yvonne T van der Schouw; Wendy Van Lippevelde; Hoang Van Minh; Natasja M Van Schoor; Irene GM van Valkengoed; Dirk Vanderschueren; Diego Vanuzzo; Gregorio Varela-Moreiras; Luz Nayibe Vargas; Senthil K Vasan; Daniel G Vasques; Tomas Vega; Gustavo Velasquez-Melendez; Biruta Velika; Charlotte Verdot; Maïté Verloigne; Giovanni Veronesi; WM Monique Verschuren; Roosmarijn Verstraeten; Lucie Viet; Frøydis N Vik; Monica Vilar; Salvador Villalpando; Jesus Vioque; Jyrki K Virtanen; Marjolein Visser; Bharathi Viswanathan; Mihaela Vladulescu; Henry Völzke; Ari Voutilainen; Martine Vrijheid; Alisha N Wade; Wan Mohamad Wan Bebakar; Wan Nazaimoon Wan Mohamud; Rildo de Souza Wanderley Júnior; Chongjian Wang; Huijun Wang; Ningli Wang; Qian Wang; Xiangjun Wang; Ya Xing Wang; Ying-Wei Wang; S Goya Wannamethee; Nicholas Wareham; Olivia Wartha; Adelheid Weber; Karen Webster-Kerr; Niels Wedderkopp; Daniel Weghuber; Wenbin Wei; Leo Westbury; Peter H Whincup; Kremlin Wickramasinghe; Kurt Widhalm; Indah S Widyahening; Andrzej Więcek; Rainford J Wilks; Karin Willeit; Peter Willeit; Julianne Williams; Tom Wilsgaard; Bogdan Wojtyniak; Roy A Wong-McClure; Andrew Wong; Emily B Wong; Frederick C Wu; Justyna Wyszyńska; Haiquan Xu; Liang Xu; Nor Azwany Yaacob; Li Yan; Weili Yan; Yang Yang; Martha Yépez García; Moein Yoosefi; Akihiro Yoshihara; Novie O Younger-Coleman; Yu-Ling Yu; Yunjiang Yu; Ahmad Faudzi Yusoff; Vassilis Zafiropulos; Ahmad A Zainuddin; Farhad Zamani; Sabina Zambon; Antonis Zampelas; Maria Elisa Zapata; Ko Ko Zaw; Tomasz Zdrojewski; Magdalena Żegleń; Kristyna Zejglicova; Tajana Zeljkovic Vrkic; Bing Zhang; Zhen-Yu Zhang; Yanitsa V Zhecheva; Bekbolat Zholdin; Paul Zimmet; Marie Zins; Julio Zuñiga Cisneros; Monika Zuziak; Majid Ezzati
  The Lancet, 404, 10455, 851, 863, Elsevier BV, Aug. 2024
  Scientific journal
• Association between oral frailty and nutritional status among hemodialysis patients aged ≥50 years.
  Masanori Iwasaki; Yuko Ohta; Natsuka Furusho; Satoko Kakuta; Kosuke Muraoka; Toshihiro Ansai; Shuji Awano; Masayo Fukuhara; Hidetoshi Nakamura
  Geriatrics & gerontology international, 01 Aug. 2024, [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, AIM: Malnutrition is a prevalent health issue among hemodialysis patients. Oral frailty, a condition characterized by impairments in multiple oral health aspects and functions, has been associated with nutritional status in the general population. We aimed to determine whether oral frailty was associated with nutritional status in hemodialysis patients aged ≥50 years. Our secondary aim was to determine the prevalence of oral frailty in this population. METHODS: This cross-sectional study included hemodialysis patients who were admitted to a single medical center. According to the Oral Frailty 5-item Checklist, oral frailty is characterized by the presence of two or more of the following criteria: (i) fewer teeth, (ii) difficulty in chewing, (iii) difficulty in swallowing, (iv) dry mouth, and (v) low articulatory oral motor skills. Patients' nutritional status was assessed using the Geriatric Nutritional Risk Index (GNRI). Multivariable ordinal logistic regression analysis was performed to assess the association between oral frailty and nutritional status (classified into three categories according to the GNRI: >98, 92-98, and <92). RESULTS: In total, 152 hemodialysis patients (55 women and 97 men) with a mean age of 70.4 years were included. The prevalence of oral frailty was 61.2%. After adjusting for health characteristics and sociodemographic background, oral frailty was associated with poor nutritional status according to the GNRI (odds ratio = 2.04, 95% confidence interval = 1.02-4.09). CONCLUSIONS: In this study, approximately 60% of hemodialysis patients aged ≥50 years exhibited oral frailty, and hemodialysis patients with oral frailty had poor nutritional status according to the GNRI. Geriatr Gerontol Int 2024; ••: ••-••.
• Evaluation of a Novel Immunochromatographic Device for Detecting Porphyromonas gingivalis in Patients with Periodontal Disease.
  Rieko Yamanaka; Michihiko Usui; Kaoru Kobayashi; Satoru Onizuka; Shingo Kasai; Kotaro Sano; Shou Hironaka; Ryota Yamasaki; Shinji Yoshii; Tsuyoshi Sato; Wataru Fujii; Masanori Iwasaki; Wataru Ariyoshi; Keisuke Nakashima; Tatsuji Nishihara
  International journal of molecular sciences, 25, 15, 26 Jul. 2024, [International Magazine]
  English, Scientific journal, Porphyromonas gingivalis is the most pathogenic periodontal bacterium in the world. Recently, P. gingivalis has been considered responsible for dysbiosis during the development of periodontitis. This study aimed to evaluate a novel immunochromatographic device using monoclonal antibodies against P. gingivalis in subgingival plaques. A total of 72 patients with chronic periodontitis and 53 periodontally healthy volunteers underwent clinical and microbiological examinations. Subgingival plaque samples were analyzed for the presence of P. gingivalis and compared using real-time polymerase chain reaction (PCR). In the periodontitis group, a significant positive correlation was observed between the test device scores and the real-time PCR results. The specificity, positive predictive value, negative predictive value, and accuracy of the test device for P. gingivalis, as determined by real-time PCR, were 98%, 94%, 89%, and 90%, respectively. There were significant differences in bacterial counts by real-time PCR among the groups with different ranges of device scores. Additionally, there was a significant positive correlation between the device scores for P. gingivalis and periodontal parameters. These results suggest that this novel immunochromatographic device can be effectively used for rapid detection and semi-quantification of P. gingivalis in subgingival plaques.
• Association Between Low Kidney Function and Excess Weight Concerning Unfavourable Periodontal Health among Community-dwelling Older Japanese Women.
  Akihiro Yoshihara; Masanori Iwasaki; Kana Suwama; Kazutoshi Nakamura
  Oral health & preventive dentistry, 22, 293, 300, 23 Jul. 2024, [International Magazine]
  English, Scientific journal, PURPOSE: To investigate the association of low renal function and overweight with poor periodontal condition in community-dwelling older Japanese women. MATERIALS AND METHODS: In total, 359 older women (age range: 55-74 years) participated in this study. Two periodontal parameters - the number of teeth with a probing pocket depth (PPD) or clinical attachment level (CAL) ≥ 4 mm - were used as the dependent variables. The principal independent variables were low renal function as defined by the estimated glomerular filtration rate (eGFR) and overweight as defined by the body mass index. Poisson regression analysis was used to calculate the ratio of means (RM). RESULTS: The RMs of the number of teeth with a PPD or CAL ≥ 4 mm in an adjusted model without an interaction term were 1.21- or 1.27-fold higher among those with an eGFR < 60, while those among the participants with an eGFR < 60 in the adjusted model with interaction terms for the number of teeth with a PPD or CAL ≥ 4 mm were 1.43- or 1.36-fold higher. In addition, increments of periodontal risk with low renal function and overweight showed a slightly smaller to negative trend. CONCLUSION: The present findings suggest a connection between unfavourable periodontal health and both renal function and being overweight among older Japanese women. A weak negative interaction was also found between poor renal condition and overweight in relation to periodontal condition.
• Serum albumin redox state as an indicator of dietary protein intake among community-dwelling older adults.
  Keiko Motokawa; Maki Shirobe; Masanori Iwasaki; Yasuaki Wada; Fuka Tabata; Kazuhiro Shigemoto; Yurie Mikami; Misato Hayakawa; Yosuke Osuka; Narumi Kojima; Hiroyuki Sasai; Hiroki Inagaki; Fumiko Miyamae; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata
  Clinical nutrition ESPEN, 63, 157, 161, 22 Jun. 2024, [International Magazine]
  English, Scientific journal, BACKGROUND AND AIMS: Serum markers capable of detecting mild levels of undernutrition, such as insufficient dietary protein intake (IDPI), have not been established among community-dwelling older adults. Although the serum albumin redox state, expressed as the ratio of reduced albumin (Alb) to total Alb (the reduced albumin ratio), has the potential to overcome this challenge, empirical epidemiological data are lacking. This study aimed to investigate the association between a serum reduced Alb ratio and dietary protein intake among community-dwelling older adults. METHODS: This study analyzed cross-sectional data from 1,005 community dwelling population (572 males and 433 females) aged 70-84 years who participated in the Itabashi Longitudinal Study on Aging. Exclusion criteria included participants with incomplete data, individuals with a history of kidney disease and high C-reactive protein (CRP) levels. The dietary protein intake was estimated using validated food frequency questionnaires. The IDPI was defined as not meeting the level recommended by the Dietary Reference Intakes for Japanese (Men ≥60 g/day, Women ≥50 g/day). RESULTS: IDPI was observed in 14.1% of the study population. Logistic regression analyses adjusted for sex, age, body weight and malnutrition showed that a serum reduced Alb ratio was significantly associated with IDPI (odds ratio = 0.962, 95% confidence interval = 0.926-0.999), whereas serum albumin concentration was not (odds ratio = 0.549, 95% confidence interval = 0.285-1.061). CONCLUSIONS: A serum reduced Alb ratio would be a useful indicator of protein insufficiency among community-dwelling older adults.
• Association of oral frailty with medical expenditure in older Japanese adults: The study of late-stage older adults in Tottori (START Tottori).
  Eri Arai; Yutaka Watanabe; Sayuri Nakagawa; Yuki Ohara; Masanori Iwasaki; Hirohiko Hirano; Kazunori Ikebe; Takahiro Ono; Katsuya Iijima; Akira Adachi; Takao Watanabe; Yutaka Yamazaki
  Gerodontology, 17 Jun. 2024, [International Magazine]
  English, Scientific journal, OBJECTS: This study aimed to determine the association between annual medical expenses and oral frailty in later-stage older adults (aged ≥ 75 years). No studies have investigated the association between medical costs and oral frailty, which would elucidate the association between oral frailty and the deterioration of mental and overall physical function. MATERIALS AND METHODS: In this cross-sectional study, 2190 adults (860 men and 1330 women aged 75-94 years) covered by the Medical System for the Elderly and residing in Tottori Prefecture, Japan, between April 2016 and March 2019, were included. Participants were classified into three groups: healthy, pre-orally frail or orally frail, based on dental health screening findings. The medical and dental expenses over the years, number of days of consultations and comorbidities were obtained from the Japanese Health Insurance Claims Database. RESULTS: The number of days of medical and dental consultations and annual medical expenses for outpatient care differed among the three study groups. A significant association was observed between oral frailty and high annual expenses for outpatient medical and dental care. Oral frailty was associated with higher medical expenses in participants with poor masticatory function. Higher and lower dental expenses were associated with subjective poor masticatory function and subjective impairment of swallowing function respectively. CONCLUSION: Medical and dental expenses for orally frail older adults are high, indicating that oral frailty may be related to the occurrence and severity of diseases other than oral health issues. Future studies should examine the mechanism by which oral weakness affects physical and mental functions.
• オーラルフレイルの新たな概念と評価方法 国民に向けてのさらなる普及・啓発と多職種連携の推進
  上田 貴之; 飯島 勝矢; 池邉 一典; 岩崎 正則; 田中 友規; 平野 浩彦; 水口 俊介
  日本歯科評論, 84, 6, 77, 82, (株)ヒョーロン・パブリッシャーズ, Jun. 2024
  Japanese
• Association Between Oral Malodor and Dementia: An 11-Year Follow-Up Study in Japan
  Duc Sy Minh Ho; Takashi Zaitsu; Hikaru Ihira; Masanori Iwasaki; Akihiro Yoshihara; Seitaro Suzuki; Manami Inoue; Kazumasa Yamagishi; Nobufumi Yasuda; Jun Aida; Tomohiro Shinozaki; Atsuhi Goto; Shoichiro Tsugane; Norie Sawada
  Journal of Alzheimer's Disease Reports, 8, 1, 805, 816, IOS Press, 17 May 2024, [Peer-reviewed]
  English, Scientific journal, Background: As infrequent social interaction is a potential risk of dementia, oral malodor may increase the risk of dementia, including Alzheimer’s disease. Objective: This study investigated the association between malodor and dementia. Methods: We used the Japan Public Health Center-based Prospective Study data obtained at Yokote City. A total of 1,493 individuals aged 56 to 75 years underwent a dental examination and self-reported survey from May 2005 to January 2006. Follow-up for the onset of dementia was conducted using long-term care insurance data from 2006 to 2016. Hazard ratios of oral malodor on dementia were estimated by the Cox proportional hazards model. The inverse probability-weighted Cox model was used as a sensitivity analysis. Results: The study comprised 1493 participants (53.6% women) with a mean age of 65.6 (SD = 5.8) years old; at the end of the follow-up, 6.4% (n = 96) developed dementia, and the percentage was 20.7 in severe malodor group. Throughout 15274.133 person-years of follow-up, the average incidence rate for the onset of dementia per 1000 person-years was 6.29. The highest incidence rate was seen in participants with severe malodor (22.4 per 1000 person-years). After adjusting for confounders, compared to those with no malodor, there was a 3.8 (95% confidence interval: 1.5 to 9.4) times greater hazard of developing dementia in participants with severe malodor. The inverse probability weighted Cox model confirmed the same trend with an adjusted marginal hazard ratio of 4.4 (1.2 to 16.4). CONCLUSIONS: A significant association between oral malodor and the onset of dementia exists.
• Oral frailty, appetite and dietary variety in late-stage older adults: A cross-sectional study (the STudy of lAte-stage oldeR adulTs in Tottori; START Tottori).
  Sayuri Nakagawa; Kazuhito Miura; Eri Arai; Kenshu Taira; Yutaka Watanabe; Maki Shirobe; Keiko Motokawa; Yuki Ohara; Masanori Iwasaki; Hirohiko Hirano; Takahiro Ono; Akira Adachi; Takao Watanabe; Yutaka Yamazaki
  Geriatrics & gerontology international, 07 May 2024, [Domestic magazines]
  English, Scientific journal, AIM: Efforts to combat frailty and preserve good health in older adults have highlighted oral frailty as an early indicator of overall frailty. Individuals showing oral frailty are at an elevated risk of insufficient nutritional intake compared with those without oral frailty; however, underlying mechanisms remain poorly explored. In this cross-sectional study, we aimed to examine the link between oral frailty and undernutrition, especially regarding poor appetite and low dietary diversity. METHODS: The analysis included 2727 late-stage older adults (mean age 79.9 ± 4.3 years) who underwent dental checkups in a prefecture in Japan from 2016 to 2020. The examination involved a questionnaire survey (covering basic information, frailty screening index, appetite index: Simplified Nutritional Appetite Questionnaire; and dietary variety: Dietary Variety Score) and a measurement survey (including intraoral confirmation, oral diadochokinesis and masticatory efficiency test). Individuals with three or more indications of poor oral function, identified through oral function assessment, were defined as showing oral frailty. Binomial logistic regression and path analyses examined associations among oral frailty, Simplified Nutritional Appetite Questionnaire and Dietary Variety Score. RESULTS: Among those analyzed, 1208 (44.3%) participants were categorized into the oral frailty group. Binomial logistic regression analysis showed that Simplified Nutritional Appetite Questionnaire (odds ratio for oral frailty per 1-point increase 0.88, 95% confidence interval 0.84-0.93) and Dietary Variety Score (odds ratio 0.95, 95% confidence interval 0.92-0.98) were significantly associated with oral frailty. The path analysis showed individual associations between each examined factor. CONCLUSIONS: Oral frailty was associated with decreased appetite and dietary variety in late-stage older adults. Geriatr Gerontol Int 2024; ••: ••-••.
• Higher-level competence: Results from the Integrated Longitudinal Studies on Aging in Japan (ILSA-J) on the shape of associations with impaired physical and cognitive functions.
  Takumi Abe; Yoshinori Fujiwara; Akihiko Kitamura; Yu Nofuji; Yukiko Nishita; Hyuma Makizako; Seungwon Jeong; Masanori Iwasaki; Minoru Yamada; Narumi Kojima; Katsuya Iijima; Shuichi Obuchi; Ken Shinmura; Rei Otsuka; Takao Suzuki
  Geriatrics & gerontology international, 24, 4, 352, 358, Apr. 2024, [Domestic magazines]
  English, Scientific journal, AIM: This study aimed to examine the relationships between levels of competence and impaired physical and cognitive functions in older adults. METHODS: We used a data set of the Integrated Longitudinal Studies on Aging in Japan for 2017 including 5475 community-dwelling older adults. Levels of competence were assessed using the Japan Science and Technology Agency Index of Competence (JST-IC). Grip strength (low grip strength: <28 kg for men and <18 kg for women) and gait speed (slow gait speed: <1.0 m/s for both sexes) were evaluated as physical function measurements, and the Mini-Mental State Examination (cognitive decline: <24 on the Mini-Mental State Examination) was used to assess cognitive function. RESULTS: The JST-IC had areas under the curve estimated from receiver operating characteristic analysis ranging from 0.65 to 0.73 for detecting low function as assessed by these tests. Restricted cubic spline curves showed that the shape of the association between the JST-IC and impaired function depended on sex and the test used. The comparison between perfect and imperfect JST-IC scores showed significant differences in the prevalence of low grip strength in both sexes, slow gait speed in women, and cognitive decline in men. CONCLUSIONS: It may be insufficient to identify those with impaired physical or cognitive function using the JST-IC. The shape of the association with the JST-IC varies across their measurements. Our findings can help interpret JST-IC scores in the context of low physical and cognitive functions. Geriatr Gerontol Int 2024; 24: 352-358.
• Proposal and validation of an equation to identify sarcopenia using bioelectrical impedance analysis-derived parameters
  Takashi Shida; Sho Hatanaka; Takahisa Ohta; Yosuke Osuka; Narumi Kojima; Keiko Motokawa; Masanori Iwasaki; Fumiko Miyamae; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata; Hiroyuki Sasai
  Nutrition, 112453, 112453, Elsevier BV, Apr. 2024
  Scientific journal
• Feasibility of Oral Function Evaluation According to Dementia Severity in Older Adults with Alzheimer's Disease.
  Maki Shirobe; Ayako Edahiro; Keiko Motokawa; Shiho Morishita; Yoshiko Motohashi; Chiaki Matsubara; Masanori Iwasaki; Yutaka Watanabe; Hirohiko Hirano
  Nutrients, 16, 7, 28 Mar. 2024, [International Magazine]
  English, Scientific journal, Oral function evaluation in older adults with dementia is important for determining appropriate and practical dietary support plans; however, it can be challenging due to their difficulties in comprehending instructions and cooperating during assessments. The feasibility of oral function evaluation has not been well studied. This cross-sectional study aimed to determine the feasibility of oral function evaluation in older adults with Alzheimer's disease (AD) according to Functional Assessment Staging of Alzheimer's Disease (FAST) stages. In total, 428 older adults with AD (45 men and 383 women; mean age: 87.2 ± 6.2 years) were included. Multilevel logistic regression models were used to examine the prevalence of participants who were unable to perform oral function evaluations, including oral diadochokinesis (ODK), repeated saliva swallow test (RSST), and modified water swallow test (MWST). In comparison to the reference category (combined FAST stage 1-3), FAST stage 7 was associated with the infeasibility of ODK (adjusted odds ratio, 95% confidence interval = 26.7, 4.2-168.6), RSST (5.9, 2.2-16.1), and MWST (8.7, 1.6-48.5, respectively). Oral function evaluation is difficult in older adults with severe AD. Simpler and more practical swallowing function assessments and indicators that can be routinely observed are required.
• オーラルフレイルに関する3学会合同ステートメント
  神崎 恒一; 水口 俊介; 荒井 秀典; 秋下 雅弘; 飯島 勝矢; 池邉 一典; 岩崎 正則; 上田 貴之; 田中 友規; 平野 浩彦; オーラルフレイルに関する3学会合同ワーキンググループ
  老年歯科医学, 38, 4, 106, 116, (一社)日本老年歯科医学会, Mar. 2024
  Japanese
• Association of decreased frequency of conversation with depression, oral function and eating alone: A cross‐sectional study of older adults during the COVID‐19 pandemic
  Yasuko Ishimoto; Yumi Kimura; Taizo Wada; Kiichi Hirayama; Emiko Kato; Mai Tatsuno; Michiko Fujisawa; Yoriko Kasahara; Masahiro Nakatsuka; Mitsuhiro Nose; Masanori Iwasaki; Satoko Kakuta; Mayumi Hirosaki; Kiyohito Okumiya; Kozo Matsubayashi; Ryota Sakamoto
  Geriatrics and Gerontology International, Mar. 2024, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, AimThis study examined the associations between geriatric factors and decreased opportunities for conversation among older adults amid a period of self‐restraint during the COVID‐19 pandemic.MethodsA cross‐sectional questionnaire‐based survey was carried out in October 2020. The participants were 204 residents aged ≥65 years staying at a private care home in Kyoto city, Japan. Logistic regression analysis was carried out with the reduction of conversation opportunities as the dependent variable, and geriatric factors as independent variables after adjusting for age and sex. We compared the decreased frequency of opportunities between residents in the assisted living wing and in the nursing care wing of the private care home.ResultsThe percentages of respondents who reported a decrease in the opportunities for conversation among themselves were 43.9% for residents in the assisted living wing and 19.7% for those in the nursing care wing. After adjusting for age and sex, the opportunities for conversation was significantly associated with the basic activities of daily living (OR 1.07, 95% CI 1.01–1.12), instrumental self‐maintenance (OR 1.25, 95% CI 1.08–1.46), intellectual activity (OR 1.35, 95% CI 1.09–1.66), depression (OR 1.13, 95% CI 1.04–1.23), depressive mood (OR 3.83, 95% CI 1.98–7.42), decreased motivation (OR 3.11, 95% CI 1.58–6.12), appetite loss (OR 4.32, 95% CI 1.54–12.07), swallowing function (OR 1.05, 95% CI 1.00–1.10), chewing difficulty (OR 2.50, 95% CI 1.31–4.75) and eating alone (OR 2.5, 95% CI 1.35–4.62).ConclusionDecreased opportunities for conversation was more perceived among older adults with higher daily functioning, suggesting that it is associated with depressed mood, oral function and solitary eating. Geriatr Gerontol Int 2024; 24: 385–391.
• Sex-specific factors associated with acceptance of smartwatches among urban older adults: the Itabashi longitudinal study on aging
  Naoki Deguchi; Yosuke Osuka; Narumi Kojima; Keiko Motokawa; Masanori Iwasaki; Hiroki Inagaki; Fumiko Miyamae; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata; Hiroyuki Sasai
  Frontiers in Public Health, 12, Frontiers Media SA, 23 Feb. 2024
  Scientific journal, Smartwatches (SW) are wearable devices that support daily life and monitor an individual’s health and activity status. This information is utilized to promote behavior modification, which could help prevent chronic diseases and manage the health of older adults. Despite being interested in SWs, older adults tend to decrease their SW usage as they age. Therefore, understanding the acceptance of SWs among older individuals can facilitate individual health management through digital health technology. This study investigated the factors associated with the acceptance of SWs among older adults in Japan and the variations in the factors by sex. This study utilized data from the 2022 Itabashi Longitudinal Study on Aging, an ongoing cohort study conducted by the Tokyo Metropolitan Institute for Geriatrics and Gerontology. We included 899 eligible individuals aged ≥65 years. Participants were classified into three groups: possessing SW (possessor group), not possessing SW but interested in possession in the future (interest group), and not interested in possession in the future (non-interest group) using a self-administered questionnaire. The level of SW acceptance was operationally defined as follows: low (non-interest group), medium (interest group), and high (possessor group). Further, we evaluated the association of acceptance and purchase intentions of SWs with sociodemographic variables, technology literacy, and health variables. Among the participants, 4.2% possessed SWs, with no significant sex difference (men, 4.2%; women, 4.3%). Among men, age &lt; 75 years, obesity, diabetes, and dyslipidemia were significantly associated with SW acceptance level. Contrastingly, among women, age &lt; 75 years, living alone, higher household income, and a high score for new device use in the technology literacy category were significantly associated with SW acceptance level. Health-related factors were associated with SW acceptance in men, while technology literacy and sociodemographic factors were associated with SW acceptance in women. Our findings may inform the development of sex-specific interventions and policies for increasing SW utilization among older adults in Japan.
• Prevalence of oral frailty and its association with dietary variety, social engagement, and physical frailty: Results from the Oral Frailty 5-Item Checklist.
  Masanori Iwasaki; Maki Shirobe; Keiko Motokawa; Tomoki Tanaka; Kazunori Ikebe; Takayuki Ueda; Shunsuke Minakuchi; Masahiro Akishita; Hidenori Arai; Katsuya Iijima; Hiroyuki Sasai; Shuichi Obuchi; Hirohiko Hirano
  Geriatrics & gerontology international, 23 Feb. 2024, [Lead author, Corresponding author], [Domestic magazines]
  English, Scientific journal, AIM: This cross-sectional study had two aims: to assess the prevalence of oral frailty (OF), according to the Oral Frailty 5-Item Checklist (OF-5), among community-dwelling older adults; and to examine the associations among oral frailty, dietary variety, social engagement, and physical frailty. METHODS: We pooled data from two population-based studies (the Otassha Study and the Itabashi Longitudinal Study on Aging). With the OF-5, OF is characterized by the presence of two or more of the following: (i) fewer teeth, (ii) difficulty in chewing, (iii) difficulty in swallowing, (iv) dry mouth, and (v) low articulatory oral motor skills. We calculated the OF prevalence for each sex. We assessed dietary variety, social engagement, and physical frailty. Generalized structural equation modeling was employed to investigate the associations among oral frailty, low dietary variety (dietary variety score ≤3), social isolation (Lubben Social Network Scale score <12), and physical frailty (Japanese version of the Cardiovascular Health Study score ≥3). RESULTS: A total of 1206 individuals (626 women and 580 men) with a mean age of 74.7 years were included. The prevalence of OF was 36.7%, and it increased with age; however, there was no significant sex difference. OF was significantly indirectly associated with physical frailty via low dietary variety (odds ratio, 1.43; 95% confidence interval, 1.04-1.97) and social isolation (odds ratio, 1.42; 95% confidence interval, 1.04-1.94). CONCLUSIONS: Two of five community-dwelling older adults exhibited OF. Low dietary variety and social isolation are potential underlying mechanisms through which OF is indirectly associated with physical frailty. Geriatr Gerontol Int 2024; ••: ••-••.
• Association between dry eye and periodontal disease in community-dwelling Japanese adults: data from the Uonoma cohort study
  Kaung Myat Thwin; Noboru Kaneko; Hikaru Okubo; Takayuki Yamaga; Kana Suwama; Akihiro Yoshihara; Masanori Iwasaki; Yumi Ito; Junta Tanaka; Ichiei Narita; Hiroshi Ogawa
  BMC Oral Health, 24, 1, Springer Science and Business Media LLC, 08 Jan. 2024
  Scientific journal, Abstract
  
  Background
  
  While research has explored the risk of periodontal disease in various eye conditions, the link between dry eye and periodontal disease remains underexplored, especially in Japanese adults. This study aims to investigate the association between dry eye and periodontal disease in community-dwelling Japanese adults.
  
  Methods
  
  This study is a subset of the Uonuma cohort study, which includes Japanese adults aged 40 years and older residing in the Uonuma area of Niigata Prefecture, Japan. Participants completed a self-administered, paper-based questionnaire. Statistical analyses, including the chi-square test, independent t test, ANOVA test, and logistic regressions, were employed to assess the association of periodontal disease with independent variables.
  
  Results
  
  Among 36,488 participants (average age 63.3 years, 47.4% men), 39.3% had a history of periodontal disease, and gender differences were statistically significant (p < 0.001). Significant associations were found between periodontal disease and dry eye diagnosis or symptoms. Univariable logistic regression revealed links between periodontal disease and age, gender, living status, alcohol consumption, remaining teeth, bite molar availability, and history of dry eye disease or symptoms. Multiple-adjusted regression found that doctor-diagnosed dry eye was associated with a higher likelihood of periodontal disease (odds ratio, 1.12; 95% confidence interval, 1.03–1.22). Participants who never experienced dryness or foreign body sensation had lower ORs of periodontal disease than those who always experienced such symptoms across all models.
  
  Conclusion
  
  A significant correlation was found between dry eye and periodontal disease in Japanese adults. Regular check-ups, early detection, and effective management of both conditions are strongly recommended.
• Effect of periodontal therapy on glycaemic control in type 2 diabetes
  Misuzu Sato; Sachiko Ono; Hayato Yamana; Akira Okada; Miho Ishimaru; Yosuke Ono; Masanori Iwasaki; Jun Aida; Hideo Yasunaga
  Journal of Clinical Periodontology, Wiley, 03 Jan. 2024
  Scientific journal, Abstract
  
  Aim
  
  This study aimed to elucidate the impact of periodontal therapy on glycaemic control in individuals with type 2 diabetes and various baseline blood glucose levels using a large‐scale claims database from Japan.
  
  Materials and Methods
  
  Using the JMDC Claims Database, we identified individuals with type 2 diabetes who underwent health check‐ups in the fiscal years 2018 or 2019 and were followed up until the next year's health check‐up. We conducted a weighted cohort analysis using stabilized inverse probability weights for treatment and censoring to estimate the effect of periodontal therapy on changes in haemoglobin A1c levels within a year. Analysis was done for different baseline haemoglobin A1c categories: 6.5%–6.9%, 7.0%–7.9% and ≥8.0%.
  
  Results
  
  Of the 4279 insured persons included in the study, 957 received periodontal therapy. Overall, there was a tendency towards improved glycaemic control among those who received periodontal therapy. Participants with baseline haemoglobin A1c levels of 7.0%–7.9% who received periodontal therapy exhibited significantly better glycaemic control compared with those without dental visits (difference; −0.094 [95% confidence interval: −0.181 to −0.007]).
  
  Conclusions
  
  Periodontal therapy may improve glycaemic control in individuals with diabetes, especially in those with haemoglobin A1c levels ≥7.0%.
• Associations of polypharmacy with frailty severity and each frailty phenotype in community-dwelling older adults: Itabashi Longitudinal Study on Aging.
  Kaori Daimaru; Yosuke Osuka; Narumi Kojima; Katsuyoshi Mizukami; Keiko Motokawa; Masanori Iwasaki; Hiroki Inagaki; Fumiko Miyamae; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata; Hiroyuki Sasai
  Geriatrics & gerontology international, 02 Jan. 2024, [Domestic magazines]
  English, Scientific journal, AIM: Although polypharmacy and frailty are concerns in older adults, there is limited understanding of their association, particularly regarding frailty severity and its phenotypes within this population. This study aimed to examine the association between polypharmacy and frailty severity or frailty phenotypes in community-dwelling older Japanese adults. METHODS: This cross-sectional study included 1021 older adults from the Itabashi Longitudinal Study on Aging. Men accounted for 45.4%, and the mean age (standard deviation) was 77.9 (5.1) years. Participants were classified into frail (n = 67), pre-frail (n = 543), and robust (n = 411) groups using the revised Japanese Cardiovascular Health Study criteria. Polypharmacy was defined as using five or more self-reported prescription drugs. Ordinal and binomial logistic regression analyses examined the association between polypharmacy and frailty severity or frailty phenotypes (weight loss, weakness, exhaustion, slowness, and low activity). These models were adjusted for age, sex, body mass index, number of comorbidities, living status, employment status, years of education, as well as drinking and smoking habits. RESULTS: The prevalence of frailty in participants with and without polypharmacy was 10.1% and 5.0%, respectively. Participants with polypharmacy were more likely to have frailty (adjusted odds ratio [95% confidence interval], 1.89 [1.40-2.57]), weight loss (1.81 [1.00-3.27]), weakness (1.50 [1.08-2.09]), and slowness (2.25 [1.29-3.94]) compared with the no-polypharmacy group. CONCLUSIONS: Polypharmacy was associated with frailty severity and three frailty phenotypes. Longitudinal studies are required to investigate whether polypharmacy can predict the development and progression of frailty. Geriatr Gerontol Int 2024; ••: ••-••.
• Dietary inflammatory index and number of functional teeth in middle-aged and older Japanese adults: A cross-sectional study using national survey data
  Masanori Iwasaki; Misuzu Sato; Dairo Takahashi; Takafumi Yamamoto
  Journal of Prosthodontic Research, 68, 4, 643, 649, Japan Prosthodontic Society, 2024
  Scientific journal
• Social Activity and Functional Decline among Community-Dwelling Older Adults in Thailand and Japan: A Comparative Cohort Study
  Kwanchit Sasiwongsaroj; Yumi Kimura; Yasuko Ishimoto; Masanori Iwasaki; Matana Kettratad-Pruksapong; Sutee Suksudaj; Yupin Songpaisan; Ryota Sakamoto; Taizo Wada; Michiko Fujisawa; Kiyohito Okumiya; Hideo Miyazaki; Kozo Matsubayashi
  International Journal of Gerontology, 18, 1, 18, 23, Jan. 2024
  Scientific journal
• Questionnaire for Medical Checkup of Old-Old is non-inferior to the Kihon Checklist in screening frailty among independent older adults aged 75 years and older: The Itabashi Longitudinal Study on Aging.
  Naoki Deguchi; Yosuke Osuka; Narumi Kojima; Keiko Motokawa; Masanori Iwasaki; Hiroki Inagaki; Fumiko Miyamae; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata; Hiroyuki Sasai
  Geriatrics & gerontology international, 12 Dec. 2023, [Domestic magazines]
  English, Scientific journal, AIM: The Questionnaire for Medical Checkup of Old-Old (QMCOO) is a 15-item dichotomous questionnaire developed for the early detection and intervention of frailty in a nationwide health checkup program targeting the old-old (i.e. aged ≥75 years). The Kihon Checklist (KCL) is a 25-item questionnaire widely used for screening and self-monitoring frailty status in administrative settings. With fewer items than the KCL, the QMCOO might expedite the frailty screening process. This study tested whether the QMCOO shows noninferiority in detecting frailty compared with the KCL. METHODS: Overall, 645 participants aged ≥75 years in the Itabashi Longitudinal Study on Aging were assessed for their frailty status according to the revised Japanese version of the Cardiovascular Health Study criteria. They also completed the QMCOO and the KCL simultaneously. We compared the discriminative performance of the two questionnaires using non-inferiority testing with an operationally defined non-inferiority margin of 10% of the area under the receiver operating characteristic curve computed from the KCL. RESULTS: The prevalence of frailty was 8.8%. The area under the receiver operating characteristic curve for the QMCOO in determining frailty was 0.76 (95% CI 0.70, 0.82), and the corresponding area under the receiver operating characteristic curve for the KCL was 0.77 (95% CI 0.69, 0.84). The QMCOO was not inferior to the KCL for frailty discrimination (P for non-inferiority = 0.006). CONCLUSIONS: The accuracy of the QMCOO for determining frailty was not inferior to that of the KCL. The QMCOO might be more acceptable and useful, as it can be applied in a shorter time with fewer questions than the KCL. Geriatr Gerontol Int 2023; ••: ••-••.
• A neighbour to consult with is important in dementia‐friendly communities: associated factors of self‐efficacy allowing older adults to continue living alone in community settings
  Chiaki Ura; Hiroki Inagaki; Mika Sugiyama; Fumiko Miyamae; Ayako Edahiro; Kae Ito; Masanori Iwasaki; Hiroyuki Sasai; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata
  Psychogeriatrics, Wiley, 05 Dec. 2023
  Scientific journal
• The association between trypsin-like protease activity in the oral cavity and kidney function in Japanese workers.
  Masanori Iwasaki; Maki Inoue; Michihiko Usui; Wataru Ariyoshi; Keisuke Nakashima; Yoshie Nagai-Yoshioka; Tatsuji Nishihara
  Journal of clinical periodontology, 28 Nov. 2023, [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, AIM: To evaluate the association between trypsin-like protease (TLP) activity in the oral cavity as an indicator of periodontal health status and kidney function in Japanese workers. MATERIALS AND METHODS: This cross-sectional study included 1117 Japanese workers (mean age = 43.8 years). Tongue-swab TLP activity was quantified as a* value (the redness intensity of the matrix disc of the TLP activity assessment kit; a larger value indicates more intense enzymatic activity in the samples and poorer periodontal health status). Kidney function was assessed using the estimated glomerular filtration rate (eGFR; a lower value indicates poorer kidney function). We performed ordinal logistic regression analyses to assess the association of the a* value with three eGFR categories: ≥90, 60-89 and <60 mL/min/1.73 m2 . RESULTS: The prevalence for each eGFR category was as follows: ≥90 (31.6%), 60-89 (63.8%) and <60 mL/min/1.73 m2 (4.6%). After adjusting for potential confounders, the a* value was found to be significantly associated with reduced kidney function. The multivariable-adjusted odds ratio (95% confidence interval) for reduced kidney function was 1.12 (1.02-1.22) per unit increase in the a* value. CONCLUSIONS: Higher TLP activity was associated with reduced kidney function in Japanese workers.
• Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
  Bin Zhou; Kate E. Sheffer; James E. Bennett; Edward W. Gregg; Goodarz Danaei; Rosie K. Singleton; Jonathan E. Shaw; Anu Mishra; Victor P. F. Lhoste; Rodrigo M. Carrillo-Larco; Andre P. Kengne; Nowell H. Phelps; Rachel A. Heap; Archie W. Rayner; Gretchen A. Stevens; Chris J. Paciorek; Leanne M. Riley; Melanie J. Cowan; Stefan Savin; Stephen Vander Hoorn; Yuan Lu; Meda E. Pavkov; Giuseppina Imperatore; Carlos A. Aguilar-Salinas; Noor Ani Ahmad; Ranjit Mohan Anjana; Kairat Davletov; Farshad Farzadfar; Clicerio González-Villalpando; Young-Ho Khang; Hyeon Chang Kim; Tiina Laatikainen; Avula Laxmaiah; Jean Claude N. Mbanya; K. M. Venkat Narayan; Ambady Ramachandran; Alisha N. Wade; Tomasz Zdrojewski; Mohsen Abbasi-Kangevari; Hanan F. Abdul Rahim; Niveen M. Abu-Rmeileh; Shalkar Adambekov; Robert J. Adams; Wichai Aekplakorn; Imelda A. Agdeppa; Javad Aghazadeh-Attari; Charles Agyemang; Ali Ahmadi; Naser Ahmadi; Nastaran Ahmadi; Soheir H. Ahmed; Kamel Ajlouni; Halima Al-Hinai; Badreya Al-Lahou; Jawad A. Al-Lawati; Deena Al Asfoor; Nawal M. Al Qaoud; Monira Alarouj; Fadia AlBuhairan; Shahla AlDhukair; Maryam A. Aldwairji; Mohamed M. Ali; Farbod Alinezhad; Abdullah Alkandari; Husam F. Alomirah; Eman Aly; Deepak N. Amarapurkar; Lars Bo Andersen; Sigmund A. Anderssen; Dolores S. Andrade; Alireza Ansari-Moghaddam; Hajer Aounallah-Skhiri; Tahir Aris; Nimmathota Arlappa; Krishna K. Aryal; Felix K. Assah; Batyrbek Assembekov; Juha Auvinen; Mária Avdičová; Kishwar Azad; Mohsen Azimi-Nezhad; Fereidoun Azizi; Flora Bacopoulou; Nagalla Balakrishna; Mohamed Bamoshmoosh; Maciej Banach; Piotr Bandosz; José R. Banegas; Carlo M. Barbagallo; Alberto Barceló; Maja Baretić; Lena Barrera; Abdul Basit; Anwar M. Batieha; Aline P. Batista; Louise A. Baur; Antonisamy Belavendra; Habiba Ben Romdhane; Mikhail Benet; Salim Berkinbayev; Antonio Bernabe-Ortiz; Ximena Berrios Carrasola; Heloísa Bettiol; Augustin F. Beybey; Santosh K. Bhargava; Elysée Claude Bika Lele; Mukharram M. Bikbov; Bihungum Bista; Peter Bjerregaard; Espen Bjertness; Marius B. Bjertness; Cecilia Björkelund; Katia V. Bloch; Anneke Blokstra; Simona Bo; Martin Bobak; Jose G. Boggia; Marialaura Bonaccio; Alice Bonilla-Vargas; Herman Borghs; Pascal Bovet; Imperia Brajkovich; Hermann Brenner; Lizzy M. Brewster; Garry R. Brian; Yajaira Briceño; Miguel Brito; Anna Bugge; Frank Buntinx; Antonio Cabrera de León; Roberta B. Caixeta; Günay Can; Ana Paula C. Cândido; Mario V. Capanzana; Naděžda Čapková; Eduardo Capuano; Rocco Capuano; Vincenzo Capuano; Viviane C. Cardoso; Axel C. Carlsson; Felipe F. Casanueva; Laura Censi; Marvin Cervantes‐Loaiza; Parinya Chamnan; Snehalatha Chamukuttan; Queenie Chan; Fadi J. Charchar; Nish Chaturvedi; Huashuai Chen; Bahman Cheraghian; María-Dolores Chirlaque; Jerzy Chudek; Renata Cifkova; Massimo Cirillo; Frank Claessens; Emmanuel Cohen; Hans Concin; Cyrus Cooper; Simona Costanzo; Chris Cowell; Ana B. Crujeiras; Juan J. Cruz; Felipe V. Cureau; Sarah Cuschieri; Graziella D’Arrigo; Eleonora d’Orsi; Jean Dallongeville; Albertino Damasceno; Saeed Dastgiri; Amalia De Curtis; Giovanni de Gaetano; Stefaan De Henauw; Mohan Deepa; Vincent DeGennaro; Stefaan Demarest; Elaine Dennison; Valérie Deschamps; Meghnath Dhimal; Zivka Dika; Shirin Djalalinia; Chiara Donfrancesco; Guanghui Dong; Maria Dorobantu; Marcus Dörr; Nico Dragano; Wojciech Drygas; Yong Du; Charmaine A. Duante; Priscilla Duboz; Anar Dushpanova; Elzbieta Dziankowska-Zaborszczyk; Narges Ebrahimi; Ricky Eddie; Ebrahim Eftekhar; Vasiliki Efthymiou; Eruke E. Egbagbe; Sareh Eghtesad; Mohammad El-Khateeb; Jalila El Ati; Denise Eldemire-Shearer; Roberto Elosua; Ofem Enang; Rajiv T. Erasmus; Raimund Erbel; Cihangir Erem; Gul Ergor; Louise Eriksen; Johan G. Eriksson; Ali Esmaeili; Roger G. Evans; Ildar Fakhradiyev; Caroline H. Fall; Elnaz Faramarzi; Mojtaba Farjam; Yosef Farzi; Mohammad Reza Fattahi; Asher Fawwad; Francisco J. Felix-Redondo; Trevor S. Ferguson; Daniel Fernández-Bergés; Marika Ferrari; Catterina Ferreccio; Haroldo S. Ferreira; Eldridge Ferrer; Edith J. M. Feskens; David Flood; Maria Forsner; Sandrine Fosse; Edward F. Fottrell; Heba M. Fouad; Damian K. Francis; Guillermo Frontera; Takuro Furusawa; Zbigniew Gaciong; Sarah P. Garnett; Magda Gasull; Andrea Gazzinelli; Ulrike Gehring; Ebrahim Ghaderi; Seyyed-Hadi Ghamari; Ali Ghanbari; Erfan Ghasemi; Oana-Florentina Gheorghe-Fronea; Anup Ghimire; Alessandro Gialluisi; Simona Giampaoli; Francesco Gianfagna; Tiffany K. Gill; Glen Gironella; Aleksander Giwercman; David Goltzman; Aleksandra Gomula; Helen Gonçalves; Mauer Gonçalves; David A. Gonzalez-Chica; Marcela Gonzalez-Gross; Juan P. González-Rivas; María-Elena González-Villalpando; Angel R. Gonzalez; Frederic Gottrand; Dušan Grafnetter; Tomasz Grodzicki; Anders Grøntved; Ramiro Guerrero; Unjali P. Gujral; Rajeev Gupta; Laura Gutierrez; Xinyi Gwee; Rosa Haghshenas; Hamid Hakimi; Ian R. Hambleton; Behrooz Hamzeh; Willem A. Hanekom; Dominique Hange; Sari Hantunen; Jie Hao; Rachakulla Hari Kumar; Javad Harooni; Seyed Mohammad Hashemi-Shahri; Jun Hata; Christin Heidemann; Rafael dos Santos Henrique; Sauli Herrala; Karl-Heinz Herzig; Ramin Heshmat; Sai Yin Ho; Michelle Holdsworth; Reza Homayounfar; Wilma M. Hopman; Andrea R. V. R. Horimoto; Claudia Hormiga; Bernardo L. Horta; Leila Houti; Christina Howitt; Thein Thein Htay; Aung Soe Htet; Maung Maung Than Htike; José María Huerta; Ilpo Tapani Huhtaniemi; Martijn Huisman; Abdullatif Husseini; Inge Huybrechts; Licia Iacoviello; Ellina M. Iakupova; Anna G. Iannone; Norazizah Ibrahim Wong; Chinwuba Ijoma; Vilma E. Irazola; Takafumi Ishida; Godsent C. Isiguzo; Sheikh Mohammed Shariful Islam; Duygu Islek; Till Ittermann; Masanori Iwasaki; Tuija Jääskeläinen; Jeremy M. Jacobs; Hashem Y. Jaddou; Michel Jadoul; Bakary Jallow; Kenneth James; Kazi M. Jamil; Edward Janus; Marjo-Riitta Jarvelin; Grazyna Jasienska; Ana Jelaković; Bojan Jelaković; Garry Jennings; Anjani Kumar Jha; Ramon O. Jimenez; Karl-Heinz Jöckel; Jari J. Jokelainen; Jost B. Jonas; Pradeep Joshi; Josipa Josipović; Farahnaz Joukar; Jacek Jóźwiak; Anthony Kafatos; Eero O. Kajantie; Zhanna Kalmatayeva; Khem B. Karki; Marzieh Katibeh; Jussi Kauhanen; Gyulli M. Kazakbaeva; François F. Kaze; Calvin Ke; Sirkka Keinänen-Kiukaanniemi; Roya Kelishadi; Maryam Keramati; Mathilde Kersting; Yousef Saleh Khader; Arsalan Khaledifar; Davood Khalili; Bahareh Kheiri; Motahareh Kheradmand; Alireza Khosravi; Ursula Kiechl-Kohlendorfer; Sophia J. Kiechl; Stefan Kiechl; Andrew Kingston; Heidi Klakk; Jana Klanova; Michael Knoflach; Patrick Kolsteren; Jürgen König; Raija Korpelainen; Paul Korrovits; Jelena Kos; Seppo Koskinen; Sudhir Kowlessur; Slawomir Koziel; Susi Kriemler; Peter Lund Kristensen; Daan Kromhout; Ruzena Kubinova; Urho M. Kujala; Mukhtar Kulimbet; Pawel Kurjata; Catherine Kyobutungi; Quang Ngoc La; Demetre Labadarios; Carl Lachat; Youcef Laid; Lachmie Lall; Tiina Lankila; Vera Lanska; Georg Lappas; Bagher Larijani; Tint Swe Latt; Martino Laurenzi; Nils Lehmann; Terho Lehtimäki; Daniel Lemogoum; Gabriel M. Leung; Yanping Li; M. Fernanda Lima-Costa; Hsien-Ho Lin; Lars Lind; Lauren Lissner; Xiaotian Liu; Esther Lopez-Garcia; Tania Lopez; José Eugenio Lozano; Dalia Luksiene; Annamari Lundqvist; Nuno Lunet; Michala Lustigová; George L. L. Machado-Coelho; Aristides M. Machado-Rodrigues; Enguerran Macia; Luisa M. Macieira; Ahmed A. Madar; Gladys E. Maestre; Stefania Maggi; Dianna J. Magliano; Emmanuella Magriplis; Gowri Mahasampath; Bernard Maire; Marcia Makdisse; Mohammad-Reza Malekpour; Fatemeh Malekzadeh; Reza Malekzadeh; Kodavanti Mallikharjuna Rao; Sofia Malyutina; Lynell V. Maniego; Yannis Manios; Masimango Imani Mannix; Fariborz Mansour-Ghanaei; Enzo Manzato; Paula Margozzini; Joany Mariño; Larissa Pruner Marques; Reynaldo Martorell; Luis P. Mascarenhas; Masoud Masinaei; Ellisiv B. Mathiesen; Tandi E. Matsha; Anselmo J. Mc Donald Posso; Shelly R. McFarlane; Stephen T. McGarvey; Sounnia Mediene Benchekor; Kirsten Mehlig; Amir Houshang Mehrparvar; Jesus D. Melgarejo; Fabián Méndez; Ana Maria B. Menezes; Alibek Mereke; Indrapal I. Meshram; Diane T. Meto; Cláudia S. Minderico; G. K. Mini; Juan Francisco Miquel; J. Jaime Miranda; Mohammad Reza Mirjalili; Pietro A. Modesti; Sahar Saeedi Moghaddam; Mostafa K. Mohamed; Kazem Mohammad; Mohammad Reza Mohammadi; Zahra Mohammadi; Noushin Mohammadifard; Reza Mohammadpourhodki; Viswanathan Mohan; Muhammad Fadhli Mohd Yusoff; Iraj Mohebbi; Niels C. Møller; Dénes Molnár; Amirabbas Momenan; Charles K. Mondo; Roger A. Montenegro Mendoza; Eric Monterrubio-Flores; Mahmood Moosazadeh; Farhad Moradpour; Alain Morejon; Luis A. Moreno; Karen Morgan; Suzanne N. Morin; Alireza Moslem; Mildrey Mosquera; Malgorzata Mossakowska; Aya Mostafa; Seyed-Ali Mostafavi; Mohammad Esmaeel Motlagh; Jorge Motta; Kelias P. Msyamboza; Thet Thet Mu; Maria L. Muiesan; Jaakko Mursu; Kamarul Imran Musa; Norlaila Mustafa; Muel Telo M. C. Muyer; Iraj Nabipour; Gabriele Nagel; Balkish M. Naidu; Farid Najafi; Jana Námešná; Vinay B. Nangia; Take Naseri; Nareemarn Neelapaichit; Azim Nejatizadeh; Ilona Nenko; Flavio Nervi; Tze Pin Ng; Chung T. Nguyen; Quang Ngoc Nguyen; Michael Y. Ni; Peng Nie; Ramfis E. Nieto-Martínez; Toshiharu Ninomiya; Marianna Noale; Oscar A. Noboa; Davide Noto; Mohannad Al Nsour; Irfan Nuhoğlu; Terence W. O’Neill; Augustine N. Odili; Kyungwon Oh; Ryutaro Ohtsuka; Mohd Azahadi Omar; Altan Onat; Sok King Ong; Obinna Onodugo; Pedro Ordunez; Rui Ornelas; Pedro J. Ortiz; Clive Osmond; Afshin Ostovar; Johanna A. Otero; Charlotte B. Ottendahl; Akaninyene Otu; Ellis Owusu-Dabo; Luigi Palmieri; Wen-Harn Pan; Songhomitra Panda-Jonas; Francesco Panza; Mariela Paoli; Suyeon Park; Mahboubeh Parsaeian; Nikhil D. Patel; Raimund Pechlaner; Ivan Pećin; João M. Pedro; Sergio Viana Peixoto; Markku Peltonen; Alexandre C. Pereira; Thaliane Mayara Pessôa dos Prazeres; Niloofar Peykari; Modou Cheyassin Phall; Son Thai Pham; Hiep Hoang Phan; Rafael N. Pichardo; Hynek Pikhart; Aida Pilav; Pavel Piler; Freda Pitakaka; Aleksandra Piwonska; Andreia N. Pizarro; Pedro Plans-Rubió; Silvia Plata; Miquel Porta; Anil Poudyal; Farhad Pourfarzi; Akram Pourshams; Hossein Poustchi; Rajendra Pradeepa; Rui Providencia; Jardena J. Puder; Solie Puhakka; Margus Punab; Mostafa Qorbani; Hedley K. Quintana; Tran Quoc Bao; Salar Rahimikazerooni; Olli Raitakari; Manuel Ramirez-Zea; Jacqueline Ramke; Rafel Ramos; Lekhraj Rampal; Sanjay Rampal; Daniel A. Rangel Reina; Mohammad-Mahdi Rashidi; Josep Redon; Jane D. P. Renner; Cézane P. Reuter; Luis Revilla; Negar Rezaei; Abbas Rezaianzadeh; Fernando Rigo; Reina G. Roa; Louise Robinson; Fernando Rodríguez-Artalejo; María del Cristo Rodriguez-Perez; Laura A. Rodríguez-Villamizar; Andrea Y. Rodríguez; Ulla Roggenbuck; Peter Rohloff; Elisabetta L. Romeo; Annika Rosengren; Adolfo Rubinstein; Petra Rust; Marcin Rutkowski; Hamideh Sabbaghi; Harshpal S. Sachdev; Alireza Sadjadi; Ali Reza Safarpour; Sare Safi; Saeid Safiri; Mohammad Hossien Saghi; Olfa Saidi; Nader Saki; Sanja Šalaj; Benoit Salanave; Jukka T. Salonen; Massimo Salvetti; Jose Sánchez-Abanto; Diana A. Santos; Lèlita C. Santos; Maria Paula Santos; Tamara R. Santos; Jouko L. Saramies; Luis B. Sardinha; Nizal Sarrafzadegan; Kai-Uwe Saum; Mariana Sbaraini; Marcia Scazufca; Beatriz D. Schaan; Christa Scheidt-Nave; Sabine Schipf; Carsten O. Schmidt; Ben Schöttker; Sara Schramm; Sylvain Sebert; Moslem Sedaghattalab; Aye Aye Sein; Sadaf G. Sepanlou; Ronel Sewpaul; Teresa Shamah-Levy; Seyed Morteza Shamshirgaran; Maryam Sharafkhah; Sanjib K. Sharma; Almaz Sharman; Amaneh Shayanrad; Ali Akbar Shayesteh; Hana Shimizu-Furusawa; Rahman Shiri; Namuna Shrestha; Khairil Si-Ramlee; Diego Augusto Santos Silva; Mary Simon; Judith Simons; Leon A. Simons; Michael Sjöström; Jolanta Slowikowska-Hilczer; Przemysław Slusarczyk; Liam Smeeth; Eugène Sobngwi; Stefan Söderberg; Agustinus Soemantri; Reecha Sofat; Vincenzo Solfrizzi; Mohammad Hossein Somi; Aïcha Soumaré; Alfonso Sousa-Poza; Karen Sparrenberger; Jan A. Staessen; Bill Stavreski; Jostein Steene-Johannessen; Peter Stehle; Aryeh D. Stein; Jochanan Stessman; Jakub Stokwiszewski; Karien Stronks; Milton F. Suarez-Ortegón; Phalakorn Suebsamran; Johan Sundström; Paibul Suriyawongpaisal; René Charles Sylva; Moyses Szklo; Abdonas Tamosiunas; Mohammed Rasoul Tarawneh; Carolina B. Tarqui-Mamani; Anne Taylor; Julie Taylor; Tania Tello; K. R. Thankappan; Holger Theobald; Xenophon Theodoridis; Nihal Thomas; Amanda G. Thrift; Erik J. Timmermans; Dwi Hapsari Tjandrarini; Hanna K. Tolonen; Janne S. Tolstrup; Maciej Tomaszewski; Murat Topbas; Laura Torres-Collado; Pierre Traissac; Areti Triantafyllou; John Tuitele; Azaliia M. Tuliakova; Marshall K. Tulloch-Reid; Tomi-Pekka Tuomainen; Evangelia Tzala; Christophe Tzourio; Peter Ueda; Eunice Ugel; Flora A. M. Ukoli; Hanno Ulmer; Hannu M. T. Uusitalo; Gonzalo Valdivia; Bert-Jan van den Born; Johan Van der Heyden; Hoang Van Minh; Lenie van Rossem; Natasja M. Van Schoor; Irene G. M. van Valkengoed; Elisabeth M. van Zutphen; Dirk Vanderschueren; Diego Vanuzzo; Senthil K. Vasan; Tomas Vega; Gustavo Velasquez-Melendez; Roosmarijn Verstraeten; Lucie Viet; Salvador Villalpando; Jesus Vioque; Jyrki K. Virtanen; Bharathi Viswanathan; Ari Voutilainen; Wan Mohamad Wan Bebakar; Wan Nazaimoon Wan Mohamud; Chongjian Wang; Ningli Wang; Qian Wang; Ya Xing Wang; Ying-Wei Wang; S. Goya Wannamethee; Karen Webster-Kerr; Niels Wedderkopp; Wenbin Wei; Leo D. Westbury; Peter H. Whincup; Kurt Widhalm; Indah S. Widyahening; Andrzej Więcek; Rainford J. Wilks; Johann Willeit; Peter Willeit; Tom Wilsgaard; Bogdan Wojtyniak; Andrew Wong; Emily B. Wong; Mark Woodward; Frederick C. Wu; Haiquan Xu; Liang Xu; Nor Azwany Yaacob; Li Yan; Weili Yan; Moein Yoosefi; Akihiro Yoshihara; Novie O. Younger-Coleman; Yu-Ling Yu; Yunjiang Yu; Ahmad Faudzi Yusoff; Ahmad A. Zainuddin; Farhad Zamani; Sabina Zambon; Antonis Zampelas; Ko Ko Zaw; Tajana Zeljkovic Vrkic; Yi Zeng; Zhen-Yu Zhang; Bekbolat Zholdin; Paul Zimmet; Emanuel Zitt; Nada Zoghlami; Julio Zuñiga Cisneros; Majid Ezzati
  Nature Medicine, Springer Science and Business Media LLC, 09 Nov. 2023
  Scientific journal, Abstract
  
  Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.
• Social isolation and well‐being among families of middle‐aged and older hikikomori people
  Sachiko Yamazaki; Chiaki Ura; Hiroki Inagaki; Mika Sugiyama; Fumiko Miyamae; Ayako Edahiro; Kae Ito; Masanori Iwasaki; Hiroyuki Sasai; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata
  Psychogeriatrics, Wiley, 06 Nov. 2023
  Scientific journal
• Development of a multiple masticatory function model based on the evaluation of sarcopenia: A cross-sectional survey of the Otassha study.
  Masaharu Murakami; Hirohiko Hirano; Masanori Iwasaki; Maki Shirobe; Ayako Edahiro; Shuichi Obuchi; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Keiko Motokawa
  Archives of oral biology, 155, 105803, 105803, Nov. 2023, [International Magazine]
  English, Scientific journal, OBJECTIVE: The masticatory function is intricately linked to several factors like natural teeth count, occlusion, masticatory muscles, and tongue coordination. This study's goal was to formulate a comprehensive masticatory function model, considering sarcopenia's conceptual structure, and subsequently validate its measurement efficacy. DESIGN: The study encompassed 753 participants (59.1 % women; mean age: 73.0 ± 5.1 years) from an urban community. The model amalgamated masseter muscle mass, occlusal force, and mixing ability. Based on the Asian Working Group for Sarcopenia 2019 classification, participants were categorized into a multiple masticatory dysfunction (MMD) or severe MMD (S-MMD) group. Logistic regression analysis gauged the model's validity, using serum albumin levels and self-reported chewing difficulties as dependent variables. RESULTS: Of the total, 61 (8.1 %) participants exhibited MMD, while 24 (3.2 %) had S-MMD. S-MMD was correlated with low serum albumin levels (odds ratio: 3.62; 95 % confidence interval: 1.07-12.29) and heightened self-reported chewing difficulties (odds ratio: 2.82; 95 % confidence interval: 1.09-7.28). CONCLUSIONS: Our multiple masticatory function model offers a straightforward approach for assessing MMD. Furthermore, the study establishes a link between S-MMD, nutritional vulnerability, and self-reported chewing challenges, thus affirming the model's credibility.
• Relationship between phase angle and lower-extremity function in older adults: Itabashi Longitudinal Study on Aging
  Sho Hatanaka; Yosuke Osuka; Narumi Kojima; Keiko Motokawa; Misato Hayakawa; Yurie Mikami; Masanori Iwasaki; Hiroki Inagaki; Fumiko Miyamae; Tsuyoshi Okamura; Hirohiko Hirano; Shuichi Awata; Hiroyuki Sasai
  Nutrition, 112289, 112289, Elsevier BV, Oct. 2023
  Scientific journal
• Barrier to sharing a dementia diagnosis with neighbors in Tokyo.
  Tsuyoshi Okamura; Tsutomu Taga; Hiroki Inagaki; Fumiko Miyamae; Chiaki Ura; Mika Sugiyama; Ayako Edahiro; Maki Shirobe; Keiko Motokawa; Narumi Kojima; Yosuke Osuka; Masanori Iwasaki; Hiroyuki Sasai; Hirohiko Hirano; Shuichi Awata
  Geriatrics & gerontology international, 23, 10, 761, 763, Oct. 2023, [Domestic magazines]
  English
• Associations between Plasma Antibody Levels against Porphyromonas gingivalis and Atrial Fibrillation among Community-Dwelling Older Individuals in Japan: A Cross-Sectional Study.
  Takashi Hoshino; Noboru Kaneko; Akihiro Yoshihara; Masanori Iwasaki; Kana Suwama; Yumi Ito; Junta Tanaka; Ichiei Narita; Hiroshi Ogawa
  Oral health & preventive dentistry, 21, 1, 339, 346, 27 Sep. 2023, [International Magazine]
  English, Scientific journal, PURPOSE: To investigate the association between plasma antibody levels against Porphyromonas gingivalis (PG) and atrial fibrillation (AF) history in community-dwelling older individuals in Japan. MATERIALS AND METHODS: This study was a subset of the Uonuma cohort study, including 3091 participants aged 60-79 years. Data were collected, including AF history as a dependent variable, plasma immunoglobulin G antibody levels against PG as an independent variable, and previously reported AF risk factors and demographic information as covariates. RESULTS: The median age of the participants was 69 years. Of the 3091 participants, 1411 (45.6%) were men, and 56 (1.8%) had an AF history. AF prevalence was significantly higher in participants with higher antibody levels against PG than in those with lower antibody levels (3.0% vs 1.4%; p = 0.005). Multivariable logistic regression analysis showed that participants with higher antibody levels against PG had twofold higher odds of having AF (odds ratio = 2.13; 95% confidence interval = 1.23-3.69). Restricted cubic spline analysis indicated a nonlinear relationship between antibody levels against PG and AF history. CONCLUSION: Plasma antibody levels against PG were associated with AF history in community-dwelling older individuals in Japan.
• Validation of self-reported articulatory oral motor skill against objectively measured repetitive articulatory rate in community-dwelling older Japanese adults: The Otassha Study.
  Masanori Iwasaki; Maki Shirobe; Keiko Motokawa; Misato Hayakawa; Kazuhito Miura; Lena Kalantar; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Yutaka Watanabe; Shuichi Obuchi; Hirohiko Hirano
  Geriatrics & gerontology international, 23, 10, 729, 735, 06 Sep. 2023, [Domestic magazines]
  English, Scientific journal, AIM: To assess the validity of self-reported articulatory oral motor skill against objectively measured repetitive articulatory rate (oral diadochokinesis [oral-DDK]) as a gold standard index for articulatory oral motor skill in community-dwelling older Japanese adults. METHODS: This cross-sectional study included 607 Japanese adults (mean age = 73.9 years). A single-item self-report questionnaire for articulatory oral motor skill was developed. Study participants completed a 1-month-interval test-retest protocol to assess reliability of the questionnaire, and the protocol was tested by the kappa statistic. Oral-DDK with /ta/ (i.e., the number of repetitions of the monosyllable /ta/ per second) was measured during the on-site examination. Low oral-DDK performance was defined as <5.2 times/s in men and <5.4 times/s in women. Oral-DDK performance, oral functions other than articulatory oral motor skill, and physical frailty were compared in the groups with and without self-reported low articulatory oral motor skill as determined by the response to the questionnaire. RESULTS: Self-reported low articulatory oral motor skill was identified in 18.5% of the study population. The self-report questionnaire had good test-retest reliability, with a kappa statistic of 0.71. Self-reported low articulatory oral motor skill was significantly associated with a lower value of oral-DDK with /ta/ and a higher proportion of low oral-DDK performance, difficulties in chewing and swallowing, dry mouth, and physical frailty. Self-report had high specificity (83.1%) but low sensitivity (42.1%) for detecting low oral-DDK performance. CONCLUSIONS: A single-item self-report questionnaire for articulatory oral motor skill had acceptable test-retest reliability and was associated with objectively measured articulatory oral motor skill. Geriatr Gerontol Int 2023; ••: ••-••.
• Oral frailty five-item checklist to predict adverse health outcomes in community-dwelling older adults: A Kashiwa cohort study.
  Tomoki Tanaka; Hirohiko Hirano; Kazunori Ikebe; Takayuki Ueda; Masanori Iwasaki; Maki Shirobe; Shunsuke Minakuchi; Masahiro Akishita; Hidenori Arai; Katsuya Iijima
  Geriatrics & gerontology international, 23, 9, 651, 659, Sep. 2023, [Domestic magazines]
  English, Scientific journal, AIM: To enable easy assessment of oral frailty; that is, an overlapping slight decline in multifaceted oral function, in any setting, we developed the oral frailty five-item checklist (OF-5), and examined its predictive validity for increased risks of physical frailty, physical disability and mortality among community-dwelling older adults. METHODS: This population-based cohort study randomly selected 2044 residents in Kashiwa, Japan, with no long-term care needs. Baseline data were collected in 2012, and follow-up data were collected in 2013, 2014, 2016, 2018 and 2021. The OF-5 includes five measures: fewer teeth, difficulty in chewing, difficulty in swallowing, dry mouth and low articulatory oral motor skills. Physical frailty was defined according to the Cardiovascular Health Study criteria. Physical disability and mortality determined from the long-term care insurance receipt database were followed for 9 years. RESULTS: Of 2031 eligible participants (mean age 73.1 ± 5.6 years; 51.1% women), 39.3% individuals with ≥2 OF-5 points had significantly increased prevalence and new-onset rate of physical frailty. After adjusting for potential confounders, oral frailty, defined as ≥2 OF-5 points, was associated with increased risks of physical disability (adjusted hazard ratio 1.40; 95% confidence interval 1.14-1.72) and mortality (adjusted hazard ratio 1.44; 95% confidence interval 1.11-1.87). The highest adjusted hazard ratios were observed in older adults with coexisting physical and oral frailty. CONCLUSIONS: The OF-5 showed strong predictive validity for physical frailty, physical disability and mortality in Japanese older adults. This assessment tool can be implemented in various settings and foster comprehensive prevention through interprofessional collaboration. Geriatr Gerontol Int 2023; 23: 651-659.
• アルコール摂取状況と歯の喪失との関連についての研究 魚沼コホート研究ベースライン調査
  諏訪間 加奈; 岩崎 正則; 伊藤 由美; 葭原 明弘
  口腔衛生学会雑誌, 73, 3, 177, 184, (一社)日本口腔衛生学会, Jul. 2023
  Japanese
• Association between Death or Hospitalization and Observable Variables of Eating and Swallowing Function among Elderly Residents in Long-Term Care Facilities: A Multicenter Prospective Cohort Study.
  Maaya Takeda; Yutaka Watanabe; Kenshu Taira; Kazuhito Miura; Yuki Ohara; Masanori Iwasaki; Kayoko Ito; Junko Nakajima; Yasuyuki Iwasa; Masataka Itoda; Yasuhiro Nishi; Yoshihiko Watanabe; Masako Kishima; Hirohiko Hirano; Maki Shirobe; Shunsuke Minakuchi; Mitsuyoshi Yoshida; Yutaka Yamazaki
  Healthcare (Basel, Switzerland), 11, 13, 22 Jun. 2023, [International Magazine]
  English, Scientific journal, This 1-year multicenter prospective cohort study aimed to determine the association between observable eating and swallowing function factors and outcomes (death/hospitalization or survival) among elderly persons in long-term care insurance facilities in Japan. Baseline assessments of factors, such as language, drooling, halitosis, hypersalivation, tongue movement, perioral muscle function, coughing, respiration after swallowing, rinsing, and oral residue, among others, were conducted. A score of 0 was considered positive, and a score of 1 or 2 was considered negative. Patient age, sex, body mass index, Barthel index, and Clinical Dementia Rating were recorded. The death/hospitalization or survival rates over 1 year were recorded, and patients were allocated into groups depending on the respective outcome (death/hospitalization group or survival group) and baseline characteristics. A total of 986 residents from 32 facilities were included, with 216 in the death/hospitalization group and 770 in the survival group. Language, salivation, halitosis, perioral muscle, coughing, respiration after swallowing, rinsing, and oral residue were significantly associated with the outcomes (p < 0.05). Therefore, routine performance of these simple assessments by caregivers may allow early detection and treatment to prevent death, pneumonia, aspiration, and malnutrition in elderly persons.
• Serum levels of vitamin D and periodontal inflammation in community-dwelling older Japanese adults: The Otassha Study.
  Masanori Iwasaki; Keiko Motokawa; Maki Shirobe; Misato Hayakawa; Yuki Ohara; Yoshiko Motohashi; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Yasuyuki Sakata; Kazushige Ihara; Yutaka Watanabe; Shuichi Obuchi; Hirohiko Hirano
  Journal of clinical periodontology, 50, 9, 1167, 1175, 15 Jun. 2023, [International Magazine]
  English, Scientific journal, AIM: To evaluate the association between vitamin D status and periodontal inflammation as determined by the periodontal inflamed surface area (PISA) in community-dwelling older adults. MATERIALS AND METHODS: This cross-sectional study included 467 Japanese adults (mean age = 73.1 years) who underwent full-mouth periodontal examinations and measurements of serum levels of 25-hydroxyvitamin D (25(OH)D). We used linear regression and restricted cubic spline models to analyse the association between exposure (serum 25(OH)D) and outcome (PISA). RESULTS: The linear regression model showed that, after adjusting for potential confounders, participants in the lowest quartile of serum 25(OH)D had 41.0 mm2 more PISA (95% confidence interval [CI]: 4.6-77.5) than the reference group (the highest quartile of serum 25(OH)D). The spline model showed that the association between serum 25(OH)D and PISA was non-linear and restricted to the low 25(OH)D range. PISA initially sharply decreased as serum 25(OH)D increased, and then the decreasing trend slowed and plateaued. The inflection point with the minimum PISA value was a serum 25(OH)D level of 27.1 ng/mL, above which there was no decreasing trend in PISA with increasing serum 25(OH)D levels. CONCLUSIONS: Low vitamin D status had an L-shaped association with periodontal inflammation in this cohort of Japanese adults.
• 5- to 15-Year Survival of Immediately Loaded Implants in Fully Edentulous Maxillae: A Multilevel Analysis in a Retrospective Cohort Study
  Yusuke Kondo; Chihiro Masaki; Taro Mukaibo; Haruka Takesue Yano; Masanori Iwasaki; Ryuji Hosokawa
  Int J Oral Macillofac Implants, 38, 3, 516, 522, Jun. 2023, [Peer-reviewed]
• Diminishing benefits of urban living for children and adolescents’ growth and development
  NCD Risk Factor Collaboration, NCD-RisC
  Nature, 615, 7954, 874, 883, Springer Science and Business Media LLC, 29 Mar. 2023, [Peer-reviewed]
  Scientific journal, Abstract
  
  Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being^1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m^–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.
• Association between Dementia Severity and Oral Hygiene Management Issues in Older Adults with Alzheimer's Disease: A Cross-Sectional Study.
  Maki Shirobe; Ayako Edahiro; Keiko Motokawa; Shiho Morishita; Yuki Ohara; Yoshiko Motohashi; Masanori Iwasaki; Yutaka Watanabe; Hirohiko Hirano
  International journal of environmental research and public health, 20, 5, 21 Feb. 2023, [International Magazine]
  English, Scientific journal, Oral hygiene management issues vary across types and clinical stages of dementia. We aimed to clarify the issues related to oral hygiene management in older adults with Alzheimer's disease (AD) according to stages defined by the Functional Assessment Staging of Alzheimer's Disease (FAST). In all, 397 records (45 men and 352 women; average age, 86.8 years; age range, 65-106) from older adults with AD were used for the cross-sectional study. We used data from a cohort of older adults (≥65 years old) who required long-term care and lived in the Omorimachi area of Yokote City, Akita Prefecture, Japan. Multilevel logistic regression analysis was conducted to examine the associations of the FAST stage, set as the exposure variable, with oral hygiene management parameters set as outcome variables. Compared to the reference category (combined FAST stage 1-3), FAST stages 6 and 7 had significantly higher odds ratios for refusal of oral health care, dependence in performing oral health care, and rinsing and gargling disability. FAST stages 4 and 7 were associated with dental plaque accumulation. Oral health care for older adults with AD should be planned appropriately according to dementia severity.
• Nutritional Evaluation and Results of an Oral Care Project in Buzen City
  Okada Keiko; Hamasaki Tomoko; Kakuta Satoko; Park Ji-Woo; Shigeyama Hiroyo; Kataoka Shota; Yamada Shima; Sakai Rie; Serita Chiho; Shiraki Hikaru; Hoshino Yukitaka; Sagara Ken; Hiroshimaya Takatoshi; Iwasaki Masanori; Aosa Taishi; Matsumoto Kenichi; Ishida Shoji; Demizu Mikio; Taira Yasusi; Otsu Natsumi; Kuratomi Keitaro; Kanemitu Mayumi; Suenaga Kimie; Kawabata Masumi; Tari Hisami; Tujimoto Tosimi; Sonoda Machiko; Yuda Hikaru; Torii Hiroko; Ito Mihoko; Kiko Manami; Nakano Nagisa; Tsutsui Shuichi; Ansai Toshihiro
  The Japanese Journal of Nutrition and Dietetics, 81, 1, 40, 49, The Japanese Society of Nutrition and Dietetics, 01 Feb. 2023
  Japanese, Objective: Buzen City is developing a home-visit dental-care project for the elderly. In this study, we surveyed and analyzed oral health before and after oral care with an aim to clarify the relationship between and changes in nutrition, nutrient intake, diversity of food intake, oral health, and general health conditions.
  
  Activity Content: In all, 207 residents of Buzen City aged 65 years or higher participated in our study. The baseline assessment included the determination of oral, physical, and nutritional status and dietary intake along with blood tests. Dentists, dental hygienists, and registered dietitians provided oral care and nutritional guidance to the participants, after which the participants were re-evaluated.
  
  Results: The participants' skeletal muscle index and mass after receiving oral care were significantly higher than the corresponding values at baseline. Furthermore, following oral care, the percentage of participants with good nutritional status increased. Therefore, multivariate logistic regression analysis was performed using the Mini Nutritional Assessment Short Form (MNA-SF) during the re-assessment. Consequently, we found that the baseline SMI and dietary variety score (DVS) were significantly associated with malnutrition.
  
  Future Tasks: This study is a practical and significant approach, since improvement in oral, nutritional, and general health conditions. Home-visit dental treatment and oral care provide an advantage in terms of understanding the eating habits and living conditions of individuals. However, there are few cases of collaboration between dentists and registered dietitians. In the future, we aim to develop a model system of oral nutrition collaboration.
• A cross-sectional study of the association between periodontitis and physical activity in the Japanese population.
  Masanori Iwasaki; Akihiro Yoshihara; Kana Suwama; Takashi Zaitsu; Seitaro Suzuki; Hikaru Ihira; Norie Sawada; Jun Aida
  Journal of periodontal research, 58, 2, 350, 359, 15 Jan. 2023, [International Magazine]
  English, Scientific journal, OBJECTIVE: The aim of this study was to determine whether physical activity (PA) is associated with periodontitis in the Japanese population. BACKGROUND: The potential association between PA and periodontitis has not been thoroughly investigated in the Japanese population. METHODS: We used cross-sectional data from the Japan Public Health Center-based Prospective Study for the Next-Generation Oral Health Study. Periodontitis was determined by a full-mouth periodontal examination. PA was assessed using a validated questionnaire. We performed multivariable ordinal logistic regression analyses to assess the association of total PA (the first quintile was set as the reference category) with periodontitis (three categories: no/mild, moderate, and severe), stratified by sex. The associations of periodontitis with domain- and intensity-specific PA were also studied in separate logistic regression models. RESULTS: This study included 2160 Japanese adults [1414 women and 746 men; mean (standard deviation) age 58.1 (9.6) years]. After adjusting for potential confounders, total PA was inversely associated with the presence and severity of periodontitis in women. The multivariable-adjusted odds ratios (95% confidence intervals) for periodontitis in the second to fifth quintiles (compared with the first quintile) of total PA were 0.81 (0.59-1.12), 0.74 (0.53-1.02), 0.77 (0.55-1.06), and 0.64 (0.46-0.89), respectively (p for trend = .01). We did not find different results when we further investigated the associations of periodontitis with domain- and intensity-specific PA. By contrast, PA was not associated with periodontitis in men. CONCLUSION: Total PA had an inverse, linear association with the presence and severity of periodontitis in Japanese women but not in Japanese men. Further prospective studies are required to determine the association between PA and periodontitis.
• 日本人男性労働者における主食の重ね食べと歯周病の関連についての横断研究
  岩崎 正則; 福原 正代; 大田 祐子; 藤澤 律子; 角田 聡子; 片岡 正太; 茂山 博代; 正木 千尋; 安細 敏弘; 細川 隆司
  口腔衛生学会雑誌, 73, 1, 42, 50, (一社)日本口腔衛生学会, Jan. 2023
  Japanese
• Association between sarcopenia and oral functions in community-dwelling older adults: A cross-sectional study.
  Yoshihiro Kugimiya; Masanori Iwasaki; Yuki Ohara; Keiko Motokawa; Ayako Edahiro; Maki Shirobe; Yutaka Watanabe; Yu Taniguchi; Satoshi Seino; Takumi Abe; Shuichi Obuchi; Hisashi Kawai; Takeshi Kera; Yoshinori Fujiwara; Akihiko Kitamura; Kazushige Ihara; Hunkyung Kim; Shoji Shinkai; Hirohiko Hirano
  Journal of cachexia, sarcopenia and muscle, 14, 1, 429, 438, Wiley, 05 Dec. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Few studies have examined the state of oral function in older adults with sarcopenia. We assessed the oral functions of community-dwelling older adults with sarcopenia from multiple perspectives to clarify their potentially low oral function. METHODS: A total of 1517 (86.2%; 990 women, 527 men; mean age 76.1 ± 7.6 years) participants were included in this study. Grip strength, gait speed and skeletal muscle mass index were assessed, and sarcopenia was evaluated according to the criteria of the Asian Working Group for Sarcopenia 2019. The degree of tongue coating, oral moisture, occlusal force, tongue-lip motor function, tongue pressure, masticatory function and swallowing function were assessed. The criteria for oral hypofunction (a disease that is a combination of multiple low oral functions) were used to assess oral function. Statistical analyses were performed using Kolmogorov-Smirnov test, unpaired t-test, Mann-Whitney U test, χ2 test, and univariate and multivariable logistic regression analyses, with each oral function as the dependent variable and sarcopenia as one of the independent variables. The significance level was set at P < 0.05. RESULTS: The prevalence rates of sarcopenia and severe sarcopenia were 14.2% and 3.8%, respectively. The prevalence of oral hypofunction was 39.9%. Compared with the robust group, the sarcopenia and severe sarcopenia groups tended to have a higher frequency of the following components (all P < 0.01): low occlusal force, low tongue-lip motor function, low tongue pressure, low masticatory function, low swallowing function and oral hypofunction. Univariate logistic regression analysis showed that sarcopenia was associated with low occlusal force, low tongue-lip motor function, low tongue pressure, low masticatory function, low swallowing function and oral hypofunction. The odds ratios and 95% confidence intervals of sarcopenia for each oral function were 2.62 [2.00, 3.43], 2.21 [1.69, 2.89], 3.66 [2.79, 4.81], 3.23 [2.46, 4.25], 1.66 [1.26, 2.20] and 3.59 [2.72, 4.72], respectively. Multivariable logistic regression analysis showed that sarcopenia was associated with low occlusal force (1.63 [1.10, 2.40]), low tongue pressure (2.28 [1.65, 3.15]), low masticatory function, (1.94 [1.27, 2.97]), low swallowing function (1.64 [1.17, 2.28]) and oral hypofunction (2.17 [1.52, 3.09]). CONCLUSIONS: This study demonstrated that multiple aspects of oral function were low among community-dwelling older adults with sarcopenia. The potential decline in oral functions in older adults with sarcopenia may have been overlooked until now. This study indicates the need for dental perspectives in intervening with older adults with sarcopenia and the need to encourage them to see dental professionals.
• Associations among internet addiction, lifestyle behaviors, and dental caries among high school students in Southwest Japan.
  Masanori Iwasaki; Satoko Kakuta; Toshihiro Ansai
  Scientific reports, 12, 1, 17342, 17342, 15 Oct. 2022, [International Magazine]
  English, Scientific journal, Internet addiction (IA) negatively affects adolescents' lifestyle behaviors. Inappropriate lifestyle behaviors could have negative effects on dental health. This cross-sectional study aimed to test whether IA was indirectly associated with dental caries through unhealthy lifestyle behaviors among high school students in southwest Japan. IA was characterized by a Young's Internet Addiction Test score of ≥ 50, unhealthy lifestyle behaviors by a cumulative count of 8 different lifestyle behaviors (termed the unhealthy lifestyle behavior index [ULBI]), and dental caries by the number of decayed, missing, and filled permanent teeth (DMFT). Poisson regression and linear regression models were fitted to the relationship, with IA as the exposure, the ULBI as the mediator, and the DMFT as the outcome. The natural indirect effect (NIE) and the proportion mediated by the ULBI were estimated by performing a mediation analysis. Overall, 1562 high school students were included. IA was observed in 406 participants and was associated with a larger DMFT. The ULBI significantly mediated the association between IA and the DMFT (NIE: incidence rate ratio = 1.05, 95% confidence interval = 1.03-1.07, proportion mediated = 64.3%). Dental caries was more common in our cohort of high school students with IA, which is partially explained by these students having unhealthy lifestyle behaviors.
• 口腔機能とサルコペニアの関係の検討 Otassya・Kusatsu Studyからの知見
  釘宮 嘉浩; 岩崎 正則; 本川 佳子; 枝広 あや子; 白部 麻樹; 渡邊 裕; 大渕 修一; 河合 恒; 江尻 愛美; 伊藤 久美子; 阿部 巧; 藤原 佳典; 北村 明彦; 新開 省二; 平野 浩彦
  日本サルコペニア・フレイル学会雑誌, 6, Suppl., 211, 211, (一社)日本サルコペニア・フレイル学会, Oct. 2022
  Japanese
• The Ability of a Novel Trypsin-like Peptidase Activity Assay Kit to Detect Red-Complex Species
  Michihiko Usui; Masanori Iwasaki; Wataru Ariyoshi; Kaoru Kobayashi; Shingo Kasai; Rieko Yamanaka; Keisuke Nakashima; Tatsuji Nishihara
  Diagnostics, 12, 9, 2172, 2172, MDPI AG, 08 Sep. 2022
  Scientific journal, The trypsin-like peptidase activity assay kit measures the trypsin-like protease produced by three red-complex species, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, causing periodontitis, and detects the presence of these bacteria in samples. The purpose of this study was to investigate the relationship between the detection of TLPs by a novel TLP-AA, ADCHECK and the detection of red-complex pathogens by real-time PCR using tongue swabs from patients with periodontitis. The detection limit of trypsin-like protease activity by ADCHECK was validated using the culture supernatants of two different Porphyromonas gingivalis bacterial strains. Real-time PCR was performed to determine the number of red-complex species in the tongue coatings of patients with periodontal disease. Trypsin-like protease activity in tongue-swab samples was scored using ADCHECK. ADCHECK successfully detected trypsin-like protease activity in 103 Porphyromonas gingivalis bacterial strains. The specificity, positive predictive value, negative predictive value, and accuracy of ADCHECK for the presence of red-complex pathogens determined by real-time PCR were 90%, 97%, 98%, and 92%, respectively. ADCHECK is an effective tool for the detection of red-complex pathogens.
• Periodontal status is associated with oral function in community‐dwelling older adults, independent of dentition status
  Yui Ueno; Masanori Iwasaki; Yumi Kimura; Satoko Kakuta; Chihiro Masaki; Taizo Wada; Ryota Sakamoto; Yasuko Ishimoto; Michiko Fujisawa; Kiyohito Okumiya; Toshihiro Ansai; Kozo Matsubayashi; Ryuji Hosokawa
  Journal of Periodontal Research, Wiley, 04 Sep. 2022
  Scientific journal
• Association between denture use and food form in older adults requiring long-term care: A multicenter cross-sectional study.
  Kenshu Taira; Yutaka Watanabe; Kazutaka Okada; Miyako Kondo; Maaya Takeda; Kayoko Ito; Junko Nakajima; Masanori Iwasaki; Masataka Itoda; Ken Inohara; Rikimaru Sasaki; Yasuhiro Nishi; Junichi Furuya; Yoshihiko Watanabe; George Umemoto; Masako Kishima; Takashi Tohara; Yuji Sato; Mitsuyohi Yoshida; Yutaka Yamazaki
  Journal of prosthodontic research, 67, 3, 366, 375, 19 Aug. 2022, [Domestic magazines]
  English, Scientific journal, PURPOSE: This study aimed to determine whether denture use contributes to maintaining and improving food forms in long-term care facility (LTCFs) residents. METHODS: In 888 residents of 37 LTCFs in Japan, the following were investigated: nutritional intake status, food forms, age, sex, Barthel index (BI), clinical dementia rating (CDR), number of teeth present, number of occlusal supports, swallowing function, and use of dentures. Among all residents, those who were well-nourished and had ≤9 occlusal supports were analyzed. Based on standardized criteria, the food forms consumed by the subjects were divided into two groups: dysphagia and normal diet, which were further classified into four levels. Analysis was performed using a generalized estimation equation with the four levels of food forms as dependent variables and age, sex, BI, CDR, presence of dysphagia, number of teeth present, and use of dentures as independent variables. RESULTS: The final analysis included 622 (70.0%) residents. Of these, 380 (61.1%) used dentures. The analyses revealed that food form was significantly associated with age (adjusted odds ratio [OR], 0.98), BI (OR, 1.04), number of teeth present (OR, 1.03), presence of dysphagia (OR, 0.44), and use of dentures (OR, 2.82). CONCLUSION: Denture use was associated with food forms among Japanese LTCF residents. This indicates that the use of dentures is related to the maintenance of food forms, even in the elderly who participate in few activities of daily living, have reduced cognitive function, and require long-term care.
• 通所サービス利用者の歯科医療ニーズの実態および歯科衛生士によるアセスメントの有用性の検討
  小原 由紀; 白部 麻樹; 森下 志穂; 松原 ちあき; 濱 芳央子; 川島 貴重; 有松 ひとみ; 久保山 裕子; 岩崎 正則; 平野 浩彦
  日本歯科衛生学会雑誌, 17, 1, 95, 95, 日本歯科衛生学会, Aug. 2022
  Japanese
• 高齢者の口腔機能に影響を与える新規歯周組織評価指標の横断調査による検証
  上野 結衣; 岩崎 正則; 野代 知孝; 宗政 翔; 向坊 太郎; 近藤 祐介; 正木 千尋; 平野 浩彦; 細川 隆司
  日本補綴歯科学会誌, 14, 特別号, 151, 151, (公社)日本補綴歯科学会, Jul. 2022
  Japanese
• 静電容量型感圧センサシートを用いた咬合力測定装置による咬合力の基準値の検討
  目黒 郁美; 五十嵐 憲太郎; 岩崎 正則; 釘宮 嘉浩; 伊藤 誠康; 河相 安彦; 渡邊 裕; 平野 浩彦
  日本補綴歯科学会誌, 14, 特別号, 303, 303, (公社)日本補綴歯科学会, Jul. 2022
  Japanese
• 高齢者の口腔機能に影響を与える新規歯周組織評価指標の横断調査による検証
  上野 結衣; 岩崎 正則; 野代 知孝; 宗政 翔; 向坊 太郎; 近藤 祐介; 正木 千尋; 平野 浩彦; 細川 隆司
  日本補綴歯科学会誌, 14, 特別号, 151, 151, (公社)日本補綴歯科学会, Jul. 2022
  Japanese
• Factors Predicting Tongue Pressure Decline among Community-Dwelling Older Adults: The Takashimadaira Study.
  Chika Takahashi; Masanori Iwasaki; Keiko Motokawa; Yutaka Watanabe; Misato Hayakawa; Yurie Mikami; Maki Shirobe; Hiroki Inagaki; Ayako Edahiro; Yuki Ohara; Hirohiko Hirano; Shoji Shinkai; Shuichi Awata
  International journal of environmental research and public health, 19, 13, 26 Jun. 2022, [International Magazine]
  English, Scientific journal, A limited number of longitudinal studies have explored factors contributing to decreases in tongue pressure (TP). This longitudinal study aimed to clarify the factors affecting TP decline among community-dwelling older adults. We followed the Takashimadaira Study participants with a baseline TP ≥ 30 kPa for 2 years. A TP of <30 kPa at follow-up was defined as TP decline. We used Poisson regression with robust standard errors to explore the factors related to TP decline. The studied baseline variables were dental status, sociodemographic characteristics, health behaviors, appetite, medical conditions, physical function, cognitive status, and anthropometric and body composition characteristics. Inverse probability weighting (IPW) was used to adjust for selection bias. Overall, 357 individuals (159 men and 198 women) with a mean (standard deviation) age of 75.9 (4.1) years were included in the analyses. Of these, 59 study participants (16.5%) exhibited TP decline. After adjusting for baseline TP and applying IPW, poor appetite (incident rate ratio [95% confidence interval] = 1.58 [1.01-2.48]), low skeletal muscle mass index (1.66 [1.02-2.70]), and cognitive impairment (1.93 [1.12-3.33]) were associated with TP decline. In conclusion, we demonstrated that baseline appetite, body composition, and cognitive status could predict future TP decline among community-dwelling older adults.
• Older adults' preferences for and actual situations of artificial hydration and nutrition in end-of-life care: An 11-year follow-up study in a care home.
  Taizo Wada; Yasuko Ishimoto; Kiichi Hirayama; Emiko Kato; Mai Tatsuno; Michiko Fujisawa; Yumi Kimura; Yoriko Kasahara; Eriko Fukutomi; Hissei Imai; Masahiro Nakatsuka; Mitsuhiro Nose; Masanori Iwasaki; Satoko Kakuta; Mayumi Hirosaki; Kiyohito Okumiya; Kozo Matsubayashi; Ryota Sakamoto
  Geriatrics & gerontology international, 22, 8, 581, 587, 18 Jun. 2022, [Domestic magazines]
  English, Scientific journal, AIM: To clarify older adults' preferences for and actual situations of artificial hydration and nutrition (AHN) in end-of-life care in a care home. METHODS: Participants were residents of a care home who had completed advance directives regarding preferred methods of AHN from 2009 to 2018. Advance directives alone were available from April 2009 to June 2016 (Wave 1), and advance care planning for AHN including advance directives was introduced in July 2016 (Wave 2). AHN preferences included (i) intensive methods (percutaneous endoscopic gastrostomy, nasogastric tube feeding and total parenteral nutrition), (ii) drip infusion, and (iii) oral intake only. Participants were followed until the end of 2020, and we checked whether decisions about AHN were based on older adults' preferences. RESULTS: In total, 272 participants had completed advance directives. Most participants preferred "oral intake only" (59.5%), followed by drip infusion (32.0%) and intensive methods (8.5%) in advance directives. Ninety of the 272 participants completed advance directives twice; 83.3% did not change their AHN preferences from Wave 1 to Wave 2. By the end of 2020, 93 of the 272 participants died in the care home. AHN was provided according to older adults' preferences in 48.9% (oral intake only), in 51.4% (drip infusion) and in 55.6% (intensive methods) of cases respectively. CONCLUSIONS: Most participants preferred oral intake only, and their preferences were reflected in decisions about actual situations of AHN in end-of-life care. To prepare for advanced dementia and senility, early advance care planning for AHN should be promoted. Geriatr Gerontol Int ••; ••: ••-•• Geriatr Gerontol Int 2022; ••: ••-••.
• 通所介護サービス利用者における低栄養リスクに関連する要因の検討
  小原 由紀; 岩崎 正則; 白部 麻樹; 岩佐 康行; 森下 志穂; 恒石 美登里; 小玉 剛; 平野 浩彦; 渡邊 裕; 吉田 光由; 水口 俊介
  日本老年歯科医学会総会・学術大会プログラム・抄録集, 33回, P2, 08, (一社)日本老年歯科医学会, Jun. 2022
  Japanese
• Observational Variables for Considering a Switch from a Normal to a Dysphagia Diet among Older Adults Requiring Long-Term Care: A One-Year Multicenter Longitudinal Study.
  Maaya Takeda; Yutaka Watanabe; Takae Matsushita; Kenshu Taira; Kazuhito Miura; Yuki Ohara; Masanori Iwasaki; Kayoko Ito; Junko Nakajima; Yasuyuki Iwasa; Masataka Itoda; Yasuhiro Nishi; Junichi Furuya; Yoshihiko Watanabe; George Umemoto; Masako Kishima; Hirohiko Hirano; Yuji Sato; Mitsuyoshi Yoshida; Yutaka Yamazaki
  International journal of environmental research and public health, 19, 11, 28 May 2022, [International Magazine]
  English, Scientific journal, This one-year multicenter longitudinal study aimed to assess whether older adult residents of long-term care facilities should switch from a normal to a dysphagia diet. Using the results of our previous cross-sectional study as baseline, older adults were subdivided into those who maintained a normal diet and those who switched to a dysphagia diet. The explanatory variables were age, sex, body mass index (BMI), Barthel Index, clinical dementia rating (CDR), and 13 simple and 5 objective oral assessments (remaining teeth, functional teeth, oral diadochokinesis, modified water swallowing test, and repetitive saliva swallowing test), which were used in binomial logistic regression analysis. Between-group comparison showed a significantly different BMI, Barthel Index, and CDR. Significant differences were also observed in simple assessments for language, drooling, tongue movement, perioral muscle function, and rinsing and in objective assessments. In multi-level analysis, switching from a normal to a dysphagia diet was significantly associated with simple assessments of tongue movement, perioral muscle function, and rinsing and with the objective assessment of the number of functional teeth. The results suggest that simple assessments can be performed regularly to screen for early signs of discrepancies between food form and eating/swallowing functions, which could lead to the provision of more appropriate food forms.
• Standard Values and Concurrent Validity of a Newly Developed Occlusal Force-Measuring Device among Community-Dwelling Older Adults: The Otassha Study.
  Masanori Iwasaki; Ichinosuke Maeda; Yota Kokubo; Yoshitomo Tanaka; Tetsuji Ueno; Yuki Ohara; Keiko Motokawa; Misato Hayakawa; Maki Shirobe; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Yutaka Watanabe; Shuichi Obuchi; Hirohiko Hirano
  International journal of environmental research and public health, 19, 9, 04 May 2022, [International Magazine]
  English, Scientific journal, Recently, an occlusal force-measuring device with a capacitive-type pressure-mapping sensor (OFMD-CPS) was developed. We aimed to establish age- and sex-specific standard values for OFMD-CPS-measured occlusal force (OF) and to assess the concurrent validity of the OFMD against another OF measuring system with a pressure-sensitive sheet (Dental Prescale II). Using data from a population-based study, we calculated the OFMD-CPS-measured OF means and deciles in 5-year age groups for each sex. The OFMD-CPS-measured OF was validated against the Dental Prescale II-measured OF with Spearman correlation coefficients. Furthermore, we calculated the area under the receiver operating characteristic curve (AUC) against the preexisting Dental Prescale II-measured OF cutoff value of 350 N. In total, 596 individuals (236 men and 360 women) with a mean (standard deviation (SD)) age of 73.7 (6.7) years were included in the analyses. The mean (SD) OFMD-CPS-measured OFs were 581.6 (284.6) N in men and 446.9 (209.9) N in women. There was a strong positive correlation (Spearman's Rho = 0.73) between OFMD-CPS-measured and Dental Prescale II-measured OF. The diagnostic accuracy of the OFMD-CPS-measured OF for the Dental Prescale II-measured OF cutoff value was high (AUC = 0.88). In conclusion, we demonstrated standard values and concurrent validity of OFMD-CPS-measured OF in community-dwelling older adults.
• フレイルおよび認知症と口腔健康の関係に焦点化した人生100年時代を見据えた歯科治療指針作成に関する研究
  平野 浩彦; 佐藤 裕二; 飯島 勝矢; 小玉 剛; 古屋 純一; 上田 貴之; 恒石 美登里; 渡邊 裕; 岩崎 正則; 小原 由紀; 枝広 あや子
  日本歯科医学会誌, 41, 27, 31, 日本歯科医学会, Mar. 2022
  Japanese
• Population-based reference values for tongue pressure in Japanese older adults: A pooled analysis of over 5,000 participants.
  Masanori Iwasaki; Yuki Ohara; Keiko Motokawa; Misato Hayakawa; Maki Shirobe; Ayako Edahiro; Yutaka Watanabe; Shuichi Awata; Tsuyoshi Okamura; Hiroki Inagaki; Naoko Sakuma; Shuichi Obuchi; Hisashi Kawai; Manami Ejiri; Kumiko Ito; Yoshinori Fujiwara; Akihiko Kitamura; Yu Nofuji; Takumi Abe; Katsuya Iijima; Tomoki Tanaka; Bo-Kyung Son; Shoji Shinkai; Hirohiko Hirano
  Journal of prosthodontic research, 67, 1, 62, 69, 27 Jan. 2022, [Domestic magazines]
  English, Scientific journal, PURPOSE: To establish age- and sex-specific population reference values for tongue pressure (TP) in community-dwelling Japanese older adults. METHODS: For this analysis, we pooled four population-based studies on community-dwelling adults aged ≥65 years that measured TP using a JMS tongue pressure measuring device. We calculated the means and deciles of TP per 5-year age group for each sex. We also estimated age trends in TP for men and women. RESULTS: In total, 5,083 individuals (2,150 men and 2,933 women, with a mean [standard deviation] age of 75.2 [6.5] years) were included in the present analysis. In male participants, the mean (standard deviation) TPs for ages 65-69, 70-74, 75-79, 80-84, and ≥85 years were 34.0 (8.4), 32.2 (8.1), 30.8 (8.3), 28.4 (8.9), and 24.4 (8.2) kPa, respectively. In female participants, the corresponding values were 31.5 (7.1), 30.5 (7.5), 29.6 (7.3), 28.4 (8.0), and 26.4 (7.6) kPa, respectively. For both sexes, there were significant declining trends in TP with advanced age. In addition, the interaction between age and sex had a significant effect on TP (regression coefficient [95% confidence interval] = -0.18 [-0.25 to -0.11] when age was modeled as a continuous variable and sex was modeled as a categorical variable [coded as 0=women, 1=men]). CONCLUSION: This study determined age- and sex-specific reference values for TP, presented as means and deciles, in community-dwelling Japanese older adults aged ≥65 years. This study also demonstrated sex differences in age-related declines in TP.
• Capacitive-Type Pressure-Mapping Sensor for Measuring Bite Force.
  Masanori Iwasaki; Ichinosuke Maeda; Yota Kokubo; Yoshitomo Tanaka; Tetsuji Ueno; Wataru Takahashi; Yutaka Watanabe; Hirohiko Hirano
  International journal of environmental research and public health, 19, 3, 24 Jan. 2022, [International Magazine]
  English, Scientific journal, Bite force is an important indicator of masticatory performance. However, existing methods for measuring bite force are either ineffective or expensive. Hence, we developed a novel capacitive-type pressure-mapping sensor that converts mechanical forces into changes in capacitance and calculates bite force. A portable device was fabricated based on this sensor sheet, and the accuracy of the bite-force measurements provided by the device was evaluated. The sensor has a thickness of 1.6 mm and has 63 measurement points. It was inserted into a dental model, where the output value was measured and compared with that of a universal testing machine (AG-IS 100 kN). A regression equation to estimate the bite force was obtained based on the relationship between the output of the capacitive-type pressure-mapping sensor and that of the load cell of the universal testing machine. The estimated bite force from the sensor and the quadratic regression equation closely resembled the known load applied by the compression tester (R2 = 0.992). We therefore conclude that the developed sensor can measure bite force accurately and effectively. A device with a built-in capacitive-type pressure-mapping sensor can potentially be a user-friendly tool for bite-force measurements in both clinical and epidemiological settings.
• Relationship between Eating Alone and Poor Appetite Using the Simplified Nutritional Appetite Questionnaire.
  Yurie Mikami; Keiko Motokawa; Maki Shirobe; Ayako Edahiro; Yuki Ohara; Masanori Iwasaki; Misato Hayakawa; Yutaka Watanabe; Hiroki Inagaki; Hunkyung Kim; Shoji Shinkai; Shuichi Awata; Hirohiko Hirano
  Nutrients, 14, 2, 14 Jan. 2022, [International Magazine]
  English, Scientific journal, One prominent factor associated with malnutrition is poor appetite. In Japan, the number of older adults living alone has increased annually. Those living alone tended to eat alone, which may lead to poor appetite. This study aimed to investigate the association between eating alone and poor appetite using an index called the Simplified Nutritional Appetite Questionnaire (SNAQ). We surveyed 818 people aged 70 and over in Takashimadaira, Itabashi-ku, Tokyo, Japan, in 2016. Comparisons were made between two groups, a poor appetite group (n = 295) and a good appetite group (n = 523), and results indicate that the poor appetite group had a higher rate of eating alone than the good appetite group (38.0% vs. 20. 1%: p < 0.001). Multivariable logistic regression (OR; 95%CI) was performed and poor appetite was significantly associated with the Geriatric Depression Scale (GDS) score (1.707; 1.200-2.427), the number of medications (1.061; 1.007-1.118), JST score (0.894; 0.841-0.950), the indication of "very healthy" on a self-rated health scale (0.343; 0.152-0.774), and reports of eating alone (1.751; 1.130-2.712). Our results suggest that eating alone is associated with a poor appetite.
• [Regular dental visits and changes in oral health among high school students during the coronavirus disease pandemic: A study using data from medical checkup at a school].
  Masanori Iwasaki; Satoko Kakuta; Toshihiro Ansai
  [Nihon koshu eisei zasshi] Japanese journal of public health, 68, 12, 865, 875, 24 Dec. 2021, [Domestic magazines]
  Japanese, Scientific journal, Objective Continuous oral health care and regular dental visits are important for maintaining oral health. As a result of the high communicability of the coronavirus disease (COVID-19), individuals are reluctant to visit medical institutions. It is as yet unclear how the oral health of the population has been affected by the interruption of regular medical services during the COVID-19 pandemic. This study aimed to examine the association between the status of regular dental visits and changes in oral health among high school students during the pandemic using data from routine medical checkups conducted at a school, as well as data obtained from a questionnaire-based survey conducted simultaneously with medical checkups.Methods This study included 878 participants (comprising freshmen and sophomores) during the 2019 academic year from a high school in Fukuoka prefecture, Japan. Data on the frequency of dental checkups and anxiety related to dental visits during the pandemic was obtained through a questionnaire-based survey. Changes in dental health and gingival status between 2019 and 2020 were determined using data from routine medical checkups at the school. Poisson regression analysis with robust standard errors was used to evaluate the association between changes in dental health and gingival status and the status of regular dental visits.Results Of 878 participants, 417 (47.5%) did not have regular dental visits, 320 (36.4%) continued to have regular dental visits, and 141 (16.1%) had interrupted regular dental visits during the pandemic. In the interrupted regular dental visit group, 30.5% of participants were anxious about visiting a dental institution, which was a significantly higher proportion than other groups. Of the 521 participants who did not have gingival inflammation at the time of dental checkup in 2019, gingival inflammation at the time of dental checkup in 2020 was observed in 31.0% of participants having no regular dental visits, 20.2% participants having regular dental visits, and 38.2% participants having interrupted regular dental visits. The multivariable adjusted incidence rate ratios were 1.95 [95% confidence interval (CI), 1.34-2.84] in the interrupted regular dental visit group and 1.50 (95%CI,1.07-2.10) in the no regular dental visit group. There was no significant association between interruption of regular dental visits and changes in dental health status.Conclusion The study results showed that there was a significant association between interruptions in regular dental visits and anxiety related to dental visits during the COVID-19 pandemic, and that a higher proportion of participants who had interruptions in regular dental visits had gingival inflammation at the time of the medical checkup at the school.
• Association between dry mouth and physical frailty among community-dwelling older adults in Japan: The Otassha Study.
  Yuki Ohara; Hisashi Kawai; Maki Shirobe; Masanori Iwasaki; Keiko Motokawa; Ayako Edahiro; Hunkyung Kim; Yoshinori Fujiwara; Kazuhige Ihara; Yutaka Watanabe; Shuichi Obuchi; Hirohiko Hirano
  Gerodontology, 39, 1, 41, 48, 11 Nov. 2021, [International Magazine]
  English, Scientific journal, OBJECTIVE: To elucidate the relationship between physical frailty and dry mouth among community-dwelling older adults in Japan. BACKGROUND: Oral hypofunction is associated with physical frailty in older adults. Dry mouth, subjectively evaluated as xerostomia and objectively measured as hyposalivation, is highly prevalent in older adults. However, few reports have used both measures of dry mouth and investigated their association with physical frailty. MATERIALS AND METHODS: This cross-sectional study included 643 individuals (mean age, 73.9 years) from the Otassha Study in 2019. Xerostomia was assessed using the 5-item Summated Xerostomia Inventory (SXI). Hyposalivation was assessed by measuring the amount of resting saliva using the modified cotton roll method. Frailty phenotypes were defined by weakness, slowness, weight loss, low physical activity level and exhaustion components, and served as the outcome variable. Participants with three or more components were considered physically frail, and those with one or two components were considered pre-frail. Ordinal logistic regression analyses were performed to evaluate the associations between physical frailty and xerostomia and hyposalivation. RESULTS: Among the participants, 4.5% and 49.8% had physical frailty and pre-frailty, respectively. In ordinal logistic regression analysis adjusted for demographic and health characteristics, the SXI score was associated with physical frailty status (adjusted odds ratio for a one-point increase in SXI, 1.12; 95% confidence interval, 1.06-1.19). However, no difference was observed between the amount of resting saliva and severity of physical frailty. CONCLUSION: Xerostomia is associated with physical frailty among community-dwelling older adults in Japan. CLINICAL TRIAL REGISTRATION: Not applicable.
• Pneumonia incidence and oral health management by dental hygienists in long-term care facilities: A 1-year prospective multicentre cohort study.
  Kaoko Hama; Yasuyuki Iwasa; Yuki Ohara; Masanori Iwasaki; Kayoko Ito; Junko Nakajima; Takae Matsushita; Takashi Tohara; Mayumi Sakamoto; Masataka Itoda; Ken Inohara; Yoshie Ozaki; Rikimaru Sasaki; Yasuhiro Nishi; Midori Tsuneishi; Junichi Furuya; Yutaka Watanabe; Yoshihiko Watanabe; Yuji Sato; Mitsuyoshi Yoshida
  Gerodontology, 09 Nov. 2021, [International Magazine]
  English, Scientific journal, OBJECTIVE: To investigate the association between oral health management (OHM) by dental hygienists and the occurrence of pneumonia, and determine the effectiveness of OHM in pneumonia prevention. BACKGROUND: In long-term care facilities in Japan, the need for professional OHM is increasing with an increase in the number of severely debilitated residents. MATERIALS AND METHODS: A 1-year prospective multicentre cohort study was conducted using data from 504 residents (63 men; mean age: 87.4 ± 7.8 years) in Japanese long-term care facilities. Basic information, medical history, willingness to engage in oral hygiene behaviour, need for OHM and oral conditions were investigated at baseline. In addition, information on the occurrence of pneumonia was collected using a follow-up survey after one year. A Poisson regression analysis with robust standard errors was conducted, with pneumonia as the dependent variable, and factors associated with OHM and pneumonia occurrence as explanatory variables. RESULTS: Overall, 349 (69.2%) residents required OHM by dental hygienists during that year of follow-up. Of those, 238 (68.2%) were provided with OHM, and 18 (7.5%) developed pneumonia. Among the 111 patients (31.8%) who were not provided with OHM, 21 (18.9%) developed pneumonia. The OHM group had lower pneumonia rates than the non-OHM group (prevalence rate ratio: 0.374; 95% CI: 0.210-0.665). CONCLUSION: Oral health management by dental hygienists was associated with a lower incidence of pneumonia among residents of long-term care facilities, underlining the importance of professional OHM for such individuals. It is recommended that OHM be practised routinely in long-term care facilities.
• 認知症重症度に注目したアルツハイマー型認知症高齢者の口腔衛生管理課題に関する検討
  白部 麻樹; 枝広 あや子; 本川 佳子; 小原 由紀; 森下 志穂; 本橋 佳子; 岩崎 正則; 渡邊 裕; 平野 浩彦
  日本公衆衛生学会総会抄録集, 80回, 439, 439, 日本公衆衛生学会, Nov. 2021
  Japanese
• The association of oral function with dietary intake and nutritional status among older adults: Latest evidence from epidemiological studies.
  Masanori Iwasaki; Hirohiko Hirano; Yuki Ohara; Keiko Motokawa
  The Japanese dental science review, 57, 128, 137, Nov. 2021, [International Magazine]
  English, Scientific journal, Inadequate and poor quality of diet and malnutrition are common and associated with adverse health outcomes, including morbidity and mortality, among older persons. This review aimed to establish the latest evidence from studies investigating the association between oral function and nutrition among older adults. An electronic search of MEDLINE using PubMed for literature published in English between March 2018 and March 2021 was conducted, and 27 papers were identified. The selected studies comprised 23 observational studies (17 cross-sectional and 6 longitudinal studies) and 4 interventional studies. Most of the observational studies demonstrated the following associations in older adults: older adults with poor oral function are likely to have poorer dietary intake and poorer nutritional status, and malnourished older adults are likely to have poorer oral function. The results of the intervention studies demonstrated that the combination of prosthodontic treatment and dietary counseling is more effective for improving dietary intake and nutritional status in older persons with tooth loss than the prosthodontic treatment alone. Our review confirmed that a relationship exists between oral function and nutrition and revealed the need for additional high-quality studies investigating comprehensive oral function, rather than a single aspect of oral function, with regard to nutritional status.
• Etiology of aggressive periodontitis in individuals of African descent.
  Akihiro Yoshida; Amal Bouziane; Samir Erraji; Leila Lakhdar; Meryem Rhissassi; Hideo Miyazaki; Toshihiro Ansai; Masanori Iwasaki; Oumkeltoum Ennibi
  The Japanese dental science review, 57, 20, 26, Nov. 2021, [International Magazine]
  English, Scientific journal, Aggressive periodontitis (AgP) is a form of periodontitis that affects adolescents and has a significantly higher prevalence in individuals of African descent. AgP typically shows familial aggregation, suggesting a genetic predisposition. Young age, good health status, rapid attachment loss, and familial aggregation are the primary features of this disease. AgP has been closely linked to specific bacterial strains of Aggregatibacter actinomycetemcomitans. A. actinomycetemcomitans strains isolated from patients with AgP produce leukotoxin (LtxA), which specifically affects polymorphonuclear leukocytes in primates, especially humans. High-throughput 16S rRNA gene sequencing and bioinformatics analyses revealed differences in the subgingival microbiota between patients with AgP and those with chronic periodontitis (ChP). The genera Atopobium and Prevotella show increased prevalences in AgP than in ChP. According to AgP susceptibility, several single nucleotide polymorphisms have been detected in different genes in individuals of African descent. Interleukin (IL)-1α and IL-1β genetic polymorphisms may be associated with the severity of both ChP and AgP. An elevated serum level of IL-17 produced by Th17 cells may be a characteristic of AgP. Analyses of the relationships among bacteria, host defenses, genetic predisposition, and numerous other factors are required to understand the progression of this disease.
• Relationship between weight loss and regular dental management of older adults residing in long-term care facilities: a 1-year multicenter longitudinal study.
  Yusuke Sunakawa; Hideki Tsugayasu; Yutaka Watanabe; Takae Matsushita; Yuki Ohara; Masanori Iwasaki; Maki Shirobe; Kayoko Ito; Junko Nakajima; Yasuyuki Iwasa; Masataka Itoda; Rikimaru Sasaki; Yasuhiro Nishi; Junichi Furuya; Yoshihiko Watanabe; Yukie Ishiguro; Hirohiko Hirano; Yuji Sato; Mitsuyoshi Yoshida; Yutaka Yamazaki
  European geriatric medicine, 13, 1, 221, 231, 28 Oct. 2021, [International Magazine]
  English, Scientific journal, PURPOSE: This study aimed to determine the association between home visits by a dentist and regular oral hygiene management by a dental hygienist (regular dental management: RDM) and weight loss among older adults in long-term care facilities. METHODS: A total of 468 older residents from 26 Japanese long-term care facilities participated in two surveys in 2018 and 2019. Participants were divided into two groups based on their diet during the baseline survey (regular diet, n = 256; dysphagia diet, n = 212). Participants with a regular diet were further divided into those who exhibited a weight loss ≥ 5% over 1 year (weight loss group: n = 77) and those with a weight loss < 5% (consistent weight group: n = 179). The explanatory variables were age, sex, baseline weight, Barthel index, and clinical dementia rating, as well as the patients' medical history of pneumonia, stroke, diabetes, and depression (which is reportedly associated with weight). Additionally, a Poisson regression with robust standard error, was carried out to analyze the explanatory variables, namely the prevalence of RDM noted during the study and functional teeth (which seemed to affect weight loss). RESULTS: A multivariate analysis revealed that older residents' lack of RDM, clinical dementia assessment, and their history of pneumonia (prevalence rate ratio: 0.35, 95% confidence interval 0.24-0.95) were all significantly associated with weight loss when on a regular diet. CONCLUSION: Thus, weight loss and RDM were related to each other. Weight loss may be suppressed by incorporating RDMs during the early nursing care for older residents on regular diets.
• Interrelationships among whole-body skeletal muscle mass, masseter muscle mass, oral function, and dentition status in older Japanese adults.
  Masanori Iwasaki; Hirohiko Hirano; Keiko Motokawa; Maki Shirobe; Ayako Edahiro; Yuki Ohara; Hisashi Kawai; Motonaga Kojima; Shuichi Obuchi; Hiroshi Murayama; Yoshinori Fujiwara; Kazushige Ihara; Shoji Shinkai; Akihiko Kitamura
  BMC geriatrics, 21, 1, 582, 582, 20 Oct. 2021, [International Magazine]
  English, Scientific journal, BACKGROUND: Generalized loss of skeletal muscle mass (SMM) may modulate or otherwise affect the loss of masseter muscle mass and be responsible for low masseter muscle performance and strength (i.e., low oral function). Moreover, dentition status can affect oral function independent of the muscle state. This cross-sectional study aimed to simultaneously investigate the relationships among whole-body SMM, masseter muscle mass, oral function (masseter muscle performance and strength), and dentition status in 1349 Japanese adults (mean age = 73.6 years). METHODS: We determined the estimated masseter muscle mass (e-MMM) based on morphological measurements of the masseter muscle. Masseter muscle performance was assessed via masticatory performance evaluation scores using gum, and strength was assessed as the maximal occlusal force. Dentition status was assessed as the number of functional teeth. SMM was measured by bioelectrical impedance analysis. Structural equation modeling stratified by sex was employed to investigate associations among SMM, e-MMM, gum score, occlusal force, and number of functional teeth. RESULTS: The direct path from SMM to e-MMM was statistically significant, as was the direct path from e-MMM to oral function (gum score and maximum occlusal force) for both sexes. We additionally confirmed that SMM indirectly affected gum score and maximum occlusal force via e-MMM (men; standardized coefficient [95% CI] = 3.64 [1.31 to 5.96] for maximum occlusal force and 0.01 [0.01 to 0.02] for gum score, women; 2.01 [0.38 to 3.81] for maximum occlusal force and 0.01 [0.002 to 0.01] for gum score). The number of functional teeth had direct effects on e-MMM, gum score, and maximum occlusal force. CONCLUSIONS: Low SMM was significantly indirectly associated with poor oral function through a low masseter muscle mass, and dentition status was independently associated with oral function.
• Association between Weight Loss and Food Form in Older Individuals Residing in Long-Term Care Facilities: 1-Year Multicenter Longitudinal Study.
  Akemi Endo; Yutaka Watanabe; Takae Matsushita; Kazutaka Okada; Yuki Ohara; Masanori Iwasaki; Kayoko Ito; Junko Nakajima; Yasuyuki Iwasa; Masataka Itoda; Rikimaru Sasaki; Yasuhiro Nishi; Junichi Furuya; Yoshihiko Watanabe; George Umemoto; Masako Kishima; Hirohiko Hirano; Yuji Sato; Mitsuyoshi Yoshida; Yutaka Yamazaki
  International journal of environmental research and public health, 18, 20, 14 Oct. 2021, [International Magazine]
  English, Scientific journal, Changing the food form for older adults requiring nursing care from a regular to dysphagia diet is thought to impact their nutritional status. We assessed the association between changes in food form and weight loss over 1 year in older adults. Older adults residing in long-term care facilities in Japan (n = 455) who participated in the baseline (2018) and follow-up (2019) surveys were divided into two groups (regular diet, n = 284; dysphagia diet, n = 171). The regular diet group was further divided into the weight loss (n = 80; weight loss ≥5% over 1 year) and weight maintenance (n = 204; weight loss <5%) groups. After 1 year, the Barthel Index significantly decreased, and the proportion of participants who switched from a regular diet to a dysphagia diet significantly increased in the weight loss group than in the weight maintenance group. Multivariate logistic regression analysis found that Barthel index variation (odds ratio (OR): 0.97, 95% confidence interval (CI): 0.94‒0.99), change from a regular diet to a dysphagia diet (OR: 4.41, 95% CI: 1.87‒10.41), and body weight at baseline (OR = 1.06, 95% CI: 1.01‒1.11) were significantly associated with weight loss. Our results suggest that maintaining the food form inhibits weight loss and improves health outcomes in older adults.
• Sleep duration and severe periodontitis in middle-aged Japanese workers.
  Masanori Iwasaki; Michihiko Usui; Wataru Ariyoshi; Keisuke Nakashima; Yoshie Nagai-Yoshioka; Maki Inoue; Kaoru Kobayashi; Tatsuji Nishihara
  Journal of clinical periodontology, 03 Oct. 2021, [International Magazine]
  English, Scientific journal, AIM: To evaluate the association between sleep duration and severe periodontitis in Japanese workers. MATERIALS AND METHODS: This cross-sectional study included 1130 workers (mean age 43.0 years) who underwent full-mouth periodontal examinations and health check-ups and completed a self-administered questionnaire that included questions on sleep duration. We used logistic regression and a restricted cubic spline model to analyze the data. RESULTS: Severe periodontitis was identified in 6.3% of the study population. The percentages of those with <5, 5-5.9, 6-6.9, 7-7.9, and ≥8 hours of sleep were 6.7%, 17.4%, 40.3%, 26.3%, and 8.9%, respectively. After adjusting for potential confounders, study participants who slept <5 hours were more likely to have severe periodontitis (adjusted odds ratio=2.64; 95% confidence interval=1.06-6.60) than those who slept 7-7.9 hours. The spline model, with a reference value of 399 minutes (the median sleep duration), showed a nonlinear association between sleep duration and severe periodontitis, where an increased prevalence of severe periodontitis was observed among only those with a shorter sleep duration. The prevalence of severe periodontitis was not increased with longer sleep duration. CONCLUSIONS: Short sleep duration was associated with severe periodontitis in this cohort of Japanese adults. This article is protected by copyright. All rights reserved.
• サルコペニアが舌口唇運動機能に与える影響の縦断的検討 お達者健診研究
  釘宮 嘉浩; 岩崎 正則; 小原 由紀; 本川 佳子; 枝広 あや子; 白部 麻樹; 渡邊 裕; 河合 恒; 大渕 修一; 藤原 佳典; 井原 一成; 上田 貴之; 平野 浩彦
  日本サルコペニア・フレイル学会雑誌, 5, Suppl., 225, 225, (一社)日本サルコペニア・フレイル学会, Oct. 2021
  Japanese
• 口腔機能低下症とサルコペニアの関連の検討:お達者健診研究
  釘宮 嘉浩; 岩崎 正則; 小原 由紀; 本川 佳子; 枝広 あや子; 白部 麻樹; 渡邊 裕; 大渕 修一; 平野 浩彦; 上田 貴之
  老年歯科医学, 36, 2, 106, 106, (一社)日本老年歯科医学会, Sep. 2021
  Japanese
• Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
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Baltazar Nunes; Terence W O'Neill; Dermot O'Reilly; Caleb Ochimana; Eiji Oda; Augustine N Odili; Kyungwon Oh; Kumiko Ohara; Ryutaro Ohtsuka; Valérie Olié; Maria Teresa A Olinto; Isabel O Oliveira; Mohd Azahadi Omar; Altan Onat; Sok King Ong; Lariane M Ono; Pedro Ordunez; Rui Ornelas; Pedro J Ortiz; Clive Osmond; Sergej M Ostojic; Afshin Ostovar; Johanna A Otero; Kim Overvad; Ellis Owusu-Dabo; Fred Michel Paccaud; Cristina Padez; Elena Pahomova; Karina Mary de Paiva; Andrzej Pająk; Domenico Palli; Luigi Palmieri; Wen-Harn Pan; Songhomitra Panda-Jonas; Francesco Panza; Mariela Paoli; Dimitrios Papandreou; Soon-Woo Park; Suyeon Park; Winsome R Parnell; Mahboubeh Parsaeian; Patrick Pasquet; Nikhil D Patel; Halyna Pavlyshyn; Ivan Pećin; Mangesh S Pednekar; João M Pedro; Nasheeta Peer; Sergio Viana Peixoto; Markku Peltonen; Alexandre C Pereira; Karen GDA Peres; Marco A Peres; Annette Peters; Janina Petkeviciene; Niloofar Peykari; Son Thai Pham; Rafael N Pichardo; Iris Pigeot; Hynek Pikhart; Aida Pilav; Lorenza Pilotto; Freda Pitakaka; Aleksandra Piwonska; Andreia n Pizarro; Pedro Plans-Rubió; Ozren Polašek; Miquel Porta; Anil Poudyal; Farhad Pourfarzi; Akram Pourshams; Hossein Poustchi; Rajendra Pradeepa; Alison J Price; Jacqueline F Price; Rui Providencia; Soile E Puhakka; Maria Puiu; Margus Punab; Radwan F Qasrawi; Mostafa Qorbani; Daniel Queiroz; Tran Quoc Bao; Ivana Radić; Ricardas Radisauskas; Salar Rahimikazerooni; Mahfuzar Rahman; Olli Raitakari; Manu Raj; Ellina M Rakhimova; Sudha Ramachandra Rao; Ambady Ramachandran; Elisabete Ramos; Lekhraj Rampal; Sanjay Rampal; Daniel A Rangel Reina; Vayia Rarra; Cassiano Ricardo Rech; Josep Redon; Paul Ferdinand M Reganit; Valéria Regecová; Luis Revilla; Abbas Rezaianzadeh; Robespierre Ribeiro; Elio Riboli; Adrian Richter; Fernando Rigo; Tobias F Rinke de Wit; Raphael M Ritti-Dias; Cynthia Robitaille; Fernando Rodríguez-Artalejo; María del Cristo Rodriguez-Perez; Laura A Rodríguez-Villamizar; Ulla Roggenbuck; Rosalba Rojas-Martinez; Dora Romaguera; Elisabetta L Romeo; Annika Rosengren; Joel GR Roy; Adolfo Rubinstein; Jean-Bernard Ruidavets; Blanca Sandra Ruiz-Betancourt; Maria Ruiz-Castell; Iuliia A Rusakova; Paola Russo; Marcin Rutkowski; Charumathi Sabanayagam; Hamideh Sabbaghi; Harshpal S Sachdev; Alireza Sadjadi; Ali Reza Safarpour; Sare Safi; Saeid Safiri; Olfa Saidi; Sibel Sakarya; Nader Saki; Benoit Salanave; Eduardo Salazar Martinez; Diego Salmerón; Veikko Salomaa; Jukka T Salonen; Massimo Salvetti; Jose Sánchez-Abanto; Susana Sans; Diana A Santos; Ina S Santos; Lèlita C Santos; Maria Paula Santos; Rute Santos; Jouko L Saramies; Luis B Sardinha; Giselle Sarganas; Nizal Sarrafzadegan; Thirunavukkarasu Sathish; Kai-Uwe Saum; Savvas Savva; Norie Sawada; Mariana Sbaraini; Marcia Scazufca; Beatriz D Schaan; Herman Schargrodsky; Sabine Schipf; Carsten O Schmidt; Peter Schnohr; Ben Schöttker; Sara Schramm; Constance Schultsz; Aletta E Schutte; Sylvain Sebert; Aye Aye Sein; Abhijit Sen; Idowu O Senbanjo; Sadaf G Sepanlou; Jennifer Servais; Svetlana A Shalnova; Teresa Shamah-Levy; Morteza Shamshirgaran; Coimbatore Subramaniam Shanthirani; Maryam Sharafkhah; Sanjib K Sharma; Jonathan E Shaw; Amaneh Shayanrad; Ali Akbar Shayesteh; Zumin Shi; Kenji Shibuya; Hana Shimizu-Furusawa; Dong Wook Shin; Majid Shirani; Rahman Shiri; Namuna Shrestha; Khairil Si-Ramlee; Alfonso Siani; Rosalynn Siantar; Abla M Sibai; Caroline Ramos de Moura Silva; Diego Augusto Santos Silva; Mary Simon; Judith Simons; Leon A Simons; Michael Sjöström; Jolanta Slowikowska-Hilczer; Przemyslaw Slusarczyk; Liam Smeeth; Hung-Kwan So; Fernanda Cunha Soares; Eugène Sobngwi; Stefan Söderberg; Agustinus Soemantri; Reecha Sofat; Vincenzo Solfrizzi; Mohammad Hossein Somi; Emily Sonestedt; Yi Song; Thorkild IA Sørensen; Elin P Sørgjerd; Maroje Sorić; Charles Sossa Jérome; Aïcha Soumaré; Bente Sparboe-Nilsen; Karen Sparrenberger; Jan A Staessen; Gregor Starc; Bill Stavreski; Jostein Steene-Johannessen; Peter Stehle; Aryeh D Stein; George S Stergiou; Jochanan Stessman; Jutta Stieber; Doris Stöckl; Tanja Stocks; Jakub Stokwiszewski; Karien Stronks; Maria Wany Strufaldi; Machi Suka; Chien-An Sun; Yn-Tz Sung; Paibul Suriyawongpaisal; Rody G Sy; Holly E Syddall; René Charles Sylva; Moyses Szklo; E Shyong Tai; Mari-Liis Tammesoo; Abdonas Tamosiunas; Eng Joo Tan; Xun Tang; Frank Tanser; Yong Tao; Mohammed Rasoul Tarawneh; Carolina B Tarqui-Mamani; Anne Taylor; Julie Taylor; William R Tebar; Grethe S Tell; Tania Tello; Yih Chung Tham; KR Thankappan; Holger Theobald; Xenophon Theodoridis; Lutgarde Thijs; Mikael Thinggaard; Nihal Thomas; Barbara Thorand; Betina H Thuesen; Erik J Timmermans; Dwi H Tjandrarini; Anne Tjonneland; Ulla Toft; Hanna K Tolonen; Janne S Tolstrup; Murat Topbas; Roman Topór-Madry; María José Tormo; Michael J Tornaritis; Maties Torrent; Laura Torres-Collado; Giota Touloumi; Pierre Traissac; Areti Triantafyllou; Dimitrios Trichopoulos; Antonia Trichopoulou; Oanh TH Trinh; Atul Trivedi; Lechaba Tshepo; Shoichiro Tsugane; Azaliia M Tuliakova; Marshall K Tulloch-Reid; Fikru Tullu; Tomi-Pekka Tuomainen; Jaakko Tuomilehto; Maria L Turley; Gilad Twig; Per Tynelius; Christophe Tzourio; Peter Ueda; Eunice Ugel; Hanno Ulmer; Hannu MT Uusitalo; Gonzalo Valdivia; Damaskini Valvi; Rob M van Dam; Bert-Jan van den Born; Johan Van der Heyden; Yvonne T van der Schouw; Koen Van Herck; Hoang Van Minh; Natasja M Van Schoor; Irene GM van Valkengoed; Elisabeth M van Zutphen; Dirk Vanderschueren; Diego Vanuzzo; Anette Varbo; Senthil K Vasan; Tomas Vega; Toomas Veidebaum; Gustavo Velasquez-Melendez; Giovanni Veronesi; WM Monique Verschuren; Roosmarijn Verstraeten; Cesar G Victora; Lucie Viet; Salvador Villalpando; Paolo Vineis; Jesus Vioque; Jyrki K Virtanen; Sophie Visvikis-Siest; Bharathi Viswanathan; Tiina Vlasoff; Peter Vollenweider; Ari Voutilainen; Alisha N Wade; Janette Walton; Elvis OA Wambiya; Wan Mohamad Wan Bebakar; Wan Nazaimoon Wan Mohamud; Rildo de Souza Wanderley Júnior; Ming-Dong Wang; Ningli Wang; Qian Wang; Xiangjun Wang; Ya Xing Wang; Ying-Wei Wang; S Goya Wannamethee; Nicholas Wareham; Wenbin Wei; Aneta Weres; Bo Werner; Peter H Whincup; Kurt Widhalm; Andrzej Wiecek; Rainford J Wilks; Johann Willeit; Peter Willeit; Emmanuel A Williams; Tom Wilsgaard; Bogdan Wojtyniak; Roy A Wong-McClure; Andrew Wong; Tien Yin Wong; Jean Woo; Frederick C Wu; Shouling Wu; Justyna Wyszynska; Haiquan Xu; Liang Xu; Nor Azwany Yaacob; Weili Yan; Ling Yang; Xiaoguang Yang; Yang Yang; Tabara Yasuharu; Xingwang Ye; Panayiotis K Yiallouros; Moein Yoosefi; Akihiro Yoshihara; San-Lin You; Novie O Younger-Coleman; Ahmad Faudzi Yusoff; Ahmad A Zainuddin; Seyed Rasoul Zakavi; Farhad Zamani; Sabina Zambon; Antonis Zampelas; Maria Elisa Zapata; Ko Ko Zaw; Kristyna Zejglicova; Tajana Zeljkovic Vrkic; Yi Zeng; Luxia Zhang; Zhen-Yu Zhang; Dong Zhao; Ming-Hui Zhao; Shiqi Zhen; Yingfeng Zheng; Bekbolat Zholdin; Dan Zhu; Marie Zins; Emanuel Zitt; Yanina Zocalo; Nada Zoghlami; Julio Zuñiga Cisneros; Majid Ezzati
  The Lancet, 398, 10304, 957, 980, Elsevier BV, Sep. 2021, [Peer-reviewed]
  English, Scientific journal
• Interruption of regular dental visits during the COVID‐19 pandemic due to concerns regarding dental visits was associated with periodontitis in Japanese office workers
  Masanori Iwasaki; Michihiko Usui; Wataru Ariyoshi; Keisuke Nakashima; Yoshie Nagai‐Yoshioka; Maki Inoue; Kaoru Kobayashi; Tatsuji Nishihara
  Journal of Periodontal Research, 56, 6, 1091, 1098, Wiley, 25 Aug. 2021, [International Magazine]
  English, Scientific journal, OBJECTIVE: To investigate the interrelationships among concerns regarding dental visits, the status of regular dental visits, and periodontal health during the coronavirus disease 2019 (COVID-19) pandemic. BACKGROUND: Continuous oral health care and regular dental visits are important for maintaining periodontal health. Due to the possibility of contracting COVID-19, individuals have been reluctant to visit medical institutions. It is unclear how the periodontal health of the Japanese population has been affected by the interruption of regular dental visits during the COVID-19 pandemic and how concerns regarding dental visits have affected attendance at regular dental visits. METHODS: This study included 199 Japanese office workers in one municipal office at Fukuoka Prefecture, Japan (average age = 42.6 years; age range = 19-77 years; 123 men and 76 women). Periodontitis was defined based on a full-mouth periodontal examination. The status of regular dental visits during the COVID-19 pandemic and concerns regarding dental visits were obtained via questionnaire. We tested the hypothesis that concerns regarding dental visits would indirectly affect periodontal health through the interruption of regular dental visits during the COVID-19 pandemic. We used mediation analysis, in which concerns regarding dental visits (present or absent) were set as the exposure, periodontitis (present or absent) was set as the outcome, and the status of regular dental visits (continued during the COVID-19 pandemic or not) was set as the mediator. RESULTS: Of the 199 study participants, 108 had a habit of attending regular dental visits. Of these, 31 (28.7%) discontinued regular dental visits during the COVID-19 pandemic. Compared to the individuals who continued regular dental visits, those who discontinued regular dental visits had a higher prevalence of periodontitis (49.4% vs 77.4%, p < 0.05) and concerns regarding dental visits (22.1% vs 64.5%, p < 0.05). Discontinuing regular dental visits significantly mediated the association between concerns regarding dental visits and periodontitis (natural indirect effect: odds ratio = 1.68, 95% confidence interval = 1.02-2.79, proportion mediated = 64.3%). CONCLUSION: The study results showed that individuals who discontinued regular dental visits during the COVID-19 pandemic due to concerns regarding dental visits had relatively poor periodontal health.
• Denture wearing is associated with nutritional status among older adults requiring long-term care: A cross-sectional study
  Ayami Meguro; Yuki Ohara; Masanori Iwasaki; Ayako Edahiro; Maki Shirobe; Kentaro Igarashi; Keiko Motokawa; Masayasu Ito; Yutaka Watanabe; Yasuhiko Kawai; Hirohiko Hirano
  Journal of Dental Sciences, Elsevier BV, Aug. 2021
  Scientific journal
• Validation of a self-report questionnaire for periodontitis in a Japanese population.
  Masanori Iwasaki; Michihiko Usui; Wataru Ariyoshi; Keisuke Nakashima; Yoshie Nagai-Yoshioka; Maki Inoue; Kaoru Kobayashi; Wenche S Borgnakke; George W Taylor; Tatsuji Nishihara
  Scientific reports, 11, 1, 15078, 15078, 23 Jul. 2021, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, We aimed to assess the validity of the self-report questionnaire for periodontitis in a Japanese population. A Japanese 9-item self-report questionnaire, developed by translating English-version questions that were used to detect periodontitis, was validated against full-mouth clinically-assessed periodontitis in 949 Japanese adults (average age = 43.2 years). Multivariable logistic regression modeling was used to calculate the area under the receiver operating characteristic curve (AUC), wherein the periodontitis case definition of the Centers for Disease Control and Prevention/American Academy of Periodontology was considered the gold standard. Severe, moderate, and mild periodontitis were identified in 6.2%, 30.0%, and 6.7% of the study population, respectively. Self-reported oral health questions combined with socio-demographic and health-related variables had an AUC > 0.70 (range, 0.71-0.87) for any periodontitis category. Four oral health questions ("have gum disease," "loose tooth," "lost bone," and "bleeding gums") were selected in the parsimonious model for severe periodontitis. The periodontitis screening score generated by the responses to these four questions had an AUC, sensitivity, and specificity of 0.82, 73.1%, and 74.3%, respectively, where the cut-off was set at 2 points. In conclusion, a locally adapted version of the self-report questionnaire had an acceptable diagnostic capacity for the detection of periodontitis in this study population.
• 地域在宅超高齢者の食事パターンと栄養素摂取量、栄養状態および嚥下状態との関連
  秋山 理加; 濱嵜 朋子; 岩崎 正則; 角田 聡子; 片岡 正太; 茂山 博代; 濃野 要; 葭原 明弘; 小川 祐司; 安細 敏弘; 宮崎 秀夫
  口腔衛生学会雑誌, 71, 3, 136, 146, (一社)日本口腔衛生学会, Jul. 2021
  Japanese
• Factors Associated with Denture Non-use in Older Adults Requiring Long-Term Care
  Ayami Meguro; Yuki Ohara; Ayako Edahiro; Maki Shirobe; Masanori Iwasaki; Kentaro Igarashi; Keiko Motokawa; Masayasu Ito; Yutaka Watanabe; Yasuhiko Kawai; Hirohiko Hirano
  Archives of Gerontology and Geriatrics, 95, 104412, 104412, Elsevier BV, Jul. 2021
  Scientific journal
• Oral hypofunction and malnutrition among community-dwelling older adults: Evidence from the Otassha study.
  Masanori Iwasaki; Keiko Motokawa; Yutaka Watanabe; Maki Shirobe; Yuki Ohara; Ayako Edahiro; Hisashi Kawai; Yoshinori Fujiwara; Hunkyung Kim; Kazushige Ihara; Shuichi Obuchi; Hirohiko Hirano
  Gerodontology, 01 Jul. 2021, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, OBJECTIVE: This study investigated the association between oral hypofunction and malnutrition among community-dwelling older adults. BACKGROUND: Oral hypofunction, a 7-component phenotype of the clinical features of oral health, has been described in Japan. Data about its association with nutritional status are limited. MATERIALS AND METHODS: This cross-sectional study enrolled 715 adults (mean age, 73.5 years; range, 65-91 years) from the Otassha Study. Oral hypofunction was defined as the presence of ≥3 of the following 7 components: poor oral hygiene; oral dryness; low occlusal force; low articulatory oral motor skill; low tongue pressure; low masticatory performance; and compromised swallowing function. The Mini Nutritional Assessment® -Short Form (MNA® -SF) was used to assess the nutritional status. Malnutrition was defined as having an MNA® -SF score of seven or less. The association between oral hypofunction and nutritional status was evaluated using ordinal logistic regression analyses. RESULTS: The prevalence rates of oral hypofunction and malnutrition were 42.7% and 4.1%, respectively. Multivariable Poisson regression analyses revealed that oral hypofunction was associated with malnutrition. The adjusted relative risk of malnutrition in the study participants with oral hypofunction was 3.00 with a 95% confidence interval of 1.29-6.98. CONCLUSION: Community-dwelling older adults whose oral functions were compromised in multiple aspects had poor nutritional status.
• Relationship between Oral Hypofunction and Sarcopenia in Community-Dwelling Older Adults: The Otassha Study.
  Yoshihiro Kugimiya; Masanori Iwasaki; Yuki Ohara; Keiko Motokawa; Ayako Edahiro; Maki Shirobe; Yutaka Watanabe; Shuichi Obuchi; Hisashi Kawai; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Takayuki Ueda; Hirohiko Hirano
  International journal of environmental research and public health, 18, 12, 21 Jun. 2021, [International Magazine]
  English, Scientific journal, Oral hypofunction, resulting from a combined decrease in multiple oral functions, may affect systemic-condition deterioration; however, few studies have examined the association between oral hypofunction and general health among older adults. In this cross-sectional study, we examined the relationship between oral hypofunction and sarcopenia in community-dwelling older adults. We included 878 adults (268 men and 610 women, mean age 76.5 ± 8.3 years). Tongue coating index, oral moisture, occlusal force, oral diadochokinesis (/pa/,/ta/,/ka/), tongue pressure, mas-ticatory function, and swallowing function were evaluated as indicators of oral hypofunction. Grip strength, gait speed, and skeletal muscle mass index were measured as diagnostic sarcopenia parameters. The association between oral hypofunction and sarcopenia was examined via logistic regression using sarcopenia as the dependent variable. Oral hypofunction prevalence was 50.5% overall, 40.3% in men, and 54.9% in women. The prevalence of sarcopenia was 18.6% overall, 9.7% in men, and 22.5% in women. A logistic regression showed oral hypofunction, age, body mass index, higher-level functional capacity, and serum albumin level were significantly associated with sarcopenia. Sarcopenia occurred at an increased frequency in patients diagnosed with oral hypofunction (odds ratio: 1.59, 95% confidence interval: 1.02-2.47); accordingly, oral hypofunction appears to be significantly associated with sarcopenia.
• 口腔機能低下症とサルコペニアの関連の検討 The Otassha Study
  釘宮 嘉浩; 岩崎 正則; 小原 由紀; 川本 佳子; 枝広 あや子; 白部 麻樹; 渡邊 裕; 大渕 修一; 平野 浩彦; 上田 貴之
  日本老年歯科医学会総会・学術大会プログラム・抄録集, 32回, 合同3, 3(歯), (一社)日本老年歯科医学会, Jun. 2021
  Japanese
• The oral function of community-dwelling older adults complaining of an oral function deterioration: An examination using the oral function-related items of the Questionnaire for Latter-stage Elderly People
  Yoshihiro Kugimiya; Masanori Iwasaki; Yuki Ohara; Keiko Motokawa; Ayako Edahiro; Maki Shirobe; Yutaka Watanabe; Shuichi Obuchi; Hisashi Kawai; Takeshi Kera; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Kentaro Igarashi; Daichi Hoshino; Hirohiko Hirano
  Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 58, 2, 245, 254, The Japan Geriatrics Society, 25 Apr. 2021
  Scientific journal
• 地域在住高齢者における口腔機能低下有訴者の口腔機能 後期高齢者の質問票を構成する口腔機能関連項目を用いた検討
  釘宮 嘉浩; 岩崎 正則; 小原 由紀; 本川 佳子; 枝広 あや子; 白部 麻樹; 渡邊 裕; 大渕 修一; 河合 恒; 解良 武士; 藤原 佳典; 井原 一成; 金 憲経; 五十嵐 憲太郎; 星野 大地; 平野 浩彦
  日本老年医学会雑誌, 58, 2, 245, 254, (一社)日本老年医学会, Apr. 2021
  Japanese
• A population-based cross-sectional study of the association between periodontitis and arterial stiffness among the older Japanese population.
  Masanori Iwasaki; Yumi Kimura; Takayuki Yamaga; Naomune Yamamoto; Motonao Ishikawa; Taizo Wada; Ryota Sakamoto; Yasuko Ishimoto; Michiko Fujisawa; Kiyohito Okumiya; Kuniaki Otsuka; Kozo Matsubayashi; Hiroshi Ogawa
  Journal of periodontal research, 56, 2, 423, 431, Apr. 2021, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, OBJECTIVE: To investigate the potential association between periodontitis and arterial stiffness among the older Japanese population. BACKGROUND: The prevalence of periodontitis is increasing in Japanese older adults. Arterial stiffness increases the risks of cardiovascular events and death, morbidity, and dementia. METHODS: This secondary analysis of data from a cross-sectional study evaluated the periodontal inflamed surface area (PISA), reflecting the amount of inflamed periodontal tissue that was estimated by a full-mouth periodontal examination. Severe periodontitis was defined per the parameters provided by the Centers for Disease Control/American Academy of Periodontology. The Cardio-Ankle Vascular Index (CAVI) was used for measuring the overall stiffness of the artery, and higher CAVI indicated increased arterial stiffness. An ordinal logistic regression model was used to evaluate the association between periodontitis and arterial stiffness. RESULTS: The analysis included 185 Japanese adults [35% men; age, mean (standard deviation) 80.2 (4.4) years]. The average PISA and the prevalence of severe periodontitis were 64.4 mm2 and 27.6%, respectively; 54 (29.2%), 56 (30.3%), and 75 (40.5%) participants were stratified to the CAVI < 9, 9 ≤ CAVI <10, and CAVI ≥ 10 groups, respectively. After adjusting for potential confounders, the odds ratio of the prevalence and severity of arterial stiffness evaluated using CAVI was 1.06 [95% confidence interval (CI) 1.01 to 1.10] for PISA per 10 mm2 and 2.12 (95% CI 1.09 to 4.11) for severe periodontitis. CONCLUSION: Periodontitis was associated with arterial stiffness among Japanese older adults. Further studies are needed to investigate whether arterial stiffness is an intermediate factor in the pathway between periodontitis and systemic diseases, including cardiovascular disease and dementia.
• Association between periodontitis and the Mediterranean diet in young Moroccan individuals.
  Masanori Iwasaki; Oum Keltoum Ennibi; Amal Bouziane; Samir Erraji; Leila Lakhdar; Meryem Rhissassi; Toshihiro Ansai; Akihiro Yoshida; Hideo Miyazaki
  Journal of periodontal research, 56, 2, 408, 414, Apr. 2021, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, BACKGROUND & OBJECTIVES: Adherence to the Mediterranean diet (MedDiet) has been reported to be associated with a lower risk of various chronic diseases. This cross-sectional study aimed to investigate the potential association between adherence to the MedDiet and periodontitis, which is highly prevalent in young Moroccan individuals. METHODS: We evaluated 1075 Moroccan individuals (72% women, mean [standard deviation] age = 20.2 [1.5] years). Adherence to the MedDiet was assessed using the MedDiet score (MDS) based on the frequency of intake of eight food groups (vegetables, legumes, fruits, cereals or potatoes, fish, red meat, dairy products, and olive oil). A value of 0 (unhealthy) or 1 (healthy) was assigned to each food group, and the MDS (range, 0-8 points) was generated by adding the individual scores, with a higher score indicating better adherence to the MedDiet. The logistic regression model was used to evaluate the MDS (high [5-8 points]/low [0-4 points]) and each component score (1/0) with the presence of periodontitis, which was determined through full-mouth periodontal examinations. Age, sex, and oral health behavior were considered as potential confounders. RESULTS: In total, 693 (64.5%) study participants showed high MDSs. Periodontitis was observed in 71 (6.6%) participants. No significant association between MDS and periodontitis was observed. Nonetheless, olive oil consumption, a component of the MDS, showed a significant inverse association with periodontitis (adjusted odds ratio = 0.55; 95% confidence interval, 0.32-0.96). CONCLUSIONS: The MedDiet was not significantly associated with periodontitis among young Moroccans. However, frequent consumption of olive oil may have a protective effect against periodontitis, although the temporal association needs to be clarified in further studies.
• Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
  Maria LC Iurilli; Bin Zhou; James E Bennett; Rodrigo M Carrillo-Larco; Marisa K Sophiea; Andrea Rodriguez-Martinez; Honor Bixby; Bethlehem D Solomon; Cristina Taddei; Goodarz Danaei; Mariachiara Di Cesare; Gretchen A Stevens; Leanne M Riley; Stefan Savin; Melanie J Cowan; Pascal Bovet; Albertino Damasceno; Adela Chirita-Emandi; Alison J Hayes; Nayu Ikeda; Rod T Jackson; Young-Ho Khang; Avula Laxmaiah; Jing Liu; J Jaime Miranda; Olfa Saidi; Sylvain Sebert; Maroje Sorić; Gregor Starc; Edward W Gregg; Leandra Abarca-Gómez; Ziad A Abdeen; Shynar Abdrakhmanova; Suhaila Abdul Ghaffar; Hanan F Abdul Rahim; Niveen M Abu-Rmeileh; Jamila Abubakar Garba; Benjamin Acosta-Cazares; Robert J Adams; Wichai Aekplakorn; Kaosar Afsana; Shoaib Afzal; Imelda A Agdeppa; Javad Aghazadeh-Attari; Carlos A Aguilar-Salinas; Charles Agyemang; Mohamad Hasnan Ahmad; Noor Ani Ahmad; Ali Ahmadi; Naser Ahmadi; Soheir H Ahmed; Wolfgang Ahrens; Gulmira Aitmurzaeva; Kamel Ajlouni; Hazzaa M Al-Hazzaa; Badreya Al-Lahou; Rajaa Al-Raddadi; Monira Alarouj; Fadia AlBuhairan; Shahla AlDhukair; Mohamed M Ali; Abdullah Alkandari; Ala'a Alkerwi; Kristine Allin; Mar Alvarez-Pedrerol; Eman Aly; Deepak N Amarapurkar; Parisa Amiri; Norbert Amougou; Philippe Amouyel; Lars Bo Andersen; Sigmund A Anderssen; Lars Ängquist; Ranjit Mohan Anjana; Alireza Ansari-Moghaddam; Hajer Aounallah-Skhiri; Joana Araújo; Inger Ariansen; Tahir Aris; Raphael E Arku; Nimmathota Arlappa; Krishna K Aryal; Thor Aspelund; Felix K Assah; Maria Cecília F Assunção; May Soe Aung; Juha Auvinen; Mária Avdicová; Shina Avi; Ana Azevedo; Mohsen Azimi-Nezhad; Fereidoun Azizi; Mehrdad Azmin; Bontha V Babu; Maja Bæksgaard Jørgensen; Azli Baharudin; Suhad Bahijri; Jennifer L Baker; Nagalla Balakrishna; Mohamed Bamoshmoosh; Maciej Banach; Piotr Bandosz; José R Banegas; Joanna Baran; Carlo M Barbagallo; Alberto Barceló; Amina Barkat; Aluisio JD Barros; Mauro Virgílio Gomes Barros; Abdul Basit; Joao Luiz D Bastos; Iqbal Bata; Anwar M Batieha; Rosangela L Batista; Zhamilya Battakova; Assembekov Batyrbek; Louise A Baur; Robert Beaglehole; Silvia Bel-Serrat; Antonisamy Belavendra; Habiba Ben Romdhane; Judith Benedics; Mikhail Benet; Ingunn Holden Bergh; Salim Berkinbayev; Antonio Bernabe-Ortiz; Gailute Bernotiene; Heloísa Bettiol; Jorge Bezerra; Aroor Bhagyalaxmi; Sumit Bharadwaj; Santosh K Bhargava; Zulfiqar A Bhutta; Hongsheng Bi; Yufang Bi; Daniel Bia; Elysée Claude Bika Lele; Mukharram M Bikbov; Bihungum Bista; Dusko J Bjelica; Peter Bjerregaard; Espen Bjertness; Marius B Bjertness; Cecilia Björkelund; Katia V Bloch; Anneke Blokstra; Simona Bo; Martin Bobak; Lynne M Boddy; Bernhard O Boehm; Heiner Boeing; Jose G Boggia; Elena Bogova; Carlos P Boissonnet; Stig E Bojesen; Marialaura Bonaccio; Vanina Bongard; Alice Bonilla-Vargas; Matthias Bopp; Herman Borghs; Lien Braeckevelt; Lutgart Braeckman; Marjolijn CE Bragt; Imperia Brajkovich; Francesco Branca; Juergen Breckenkamp; João Breda; Hermann Brenner; Lizzy M Brewster; Garry R Brian; Lacramioara Brinduse; Sinead Brophy; Graziella Bruno; H Bas Bueno-de-Mesquita; Anna Bugge; Marta Buoncristiano; Genc Burazeri; Con Burns; Antonio Cabrera de León; Joseph Cacciottolo; Hui Cai; Tilema Cama; Christine Cameron; José Camolas; Günay Can; Ana Paula C Cândido; Felicia Cañete; Mario V Capanzana; Nadežda Capková; Eduardo Capuano; Vincenzo Capuano; Marloes Cardol; Viviane C Cardoso; Axel C Carlsson; Esteban Carmuega; Joana Carvalho; José A Casajús; Felipe F Casanueva; Ertugrul Celikcan; Laura Censi; Marvin Cervantes-Loaiza; Juraci A Cesar; Snehalatha Chamukuttan; Angelique W Chan; Queenie Chan; Himanshu K Chaturvedi; Nish Chaturvedi; Norsyamlina Che Abdul Rahim; Miao Li Chee; Chien-Jen Chen; Fangfang Chen; Huashuai Chen; Shuohua Chen; Zhengming Chen; Ching-Yu Cheng; Bahman Cheraghian; Angela Chetrit; Ekaterina Chikova-Iscener; Arnaud Chiolero; Shu-Ti Chiou; María-Dolores Chirlaque; Belong Cho; Kaare Christensen; Diego G Christofaro; Jerzy Chudek; Renata Cifkova; Michelle Cilia; Eliza Cinteza; Frank Claessens; Janine Clarke; Els Clays; Emmanuel Cohen; Hans Concin; Susana C Confortin; Cyrus Cooper; Tara C Coppinger; Eva Corpeleijn; Simona Costanzo; Dominique Cottel; Chris Cowell; Cora L Craig; Amelia C Crampin; Ana B Crujeiras; Semánová Csilla; Alexandra M Cucu; Liufu Cui; Felipe V Cureau; Ewelina Czenczek-Lewandowska; Graziella D'Arrigo; Eleonora d'Orsi; Liliana Dacica; María Ángeles Dal Re Saavedra; Jean Dallongeville; Camilla T Damsgaard; Rachel Dankner; Thomas M Dantoft; Parasmani Dasgupta; Saeed Dastgiri; Luc Dauchet; Kairat Davletov; Guy De Backer; Dirk De Bacquer; Giovanni de Gaetano; Stefaan De Henauw; Paula Duarte de Oliveira; David De Ridder; Karin De Ridder; Susanne R de Rooij; Delphine De Smedt; Mohan Deepa; Alexander D Deev; Vincent Jr DeGennaro; Abbas Dehghan; Hélène Delisle; Francis Delpeuch; Stefaan Demarest; Elaine Dennison; Katarzyna Dereń; Valérie Deschamps; Meghnath Dhimal; Augusto F Di Castelnuovo; Juvenal Soares Dias-da-Costa; María Elena Díaz-Sánchez; Alejandro Diaz; Zivka Dika; Shirin Djalalinia; Visnja Djordjic; Ha TP Do; Annette J Dobson; Maria Benedetta Donati; Chiara Donfrancesco; Silvana P Donoso; Angela Döring; Maria Dorobantu; Ahmad Reza Dorosty; Kouamelan Doua; Nico Dragano; Wojciech Drygas; Jia Li Duan; Charmaine A Duante; Priscilla Duboz; Rosemary B Duda; Vesselka Duleva; Virginija Dulskiene; Samuel C Dumith; Anar Dushpanova; Vilnis Dzerve; Elzbieta Dziankowska-Zaborszczyk; Ricky Eddie; Ebrahim Eftekhar; Eruke E Egbagbe; Robert Eggertsen; Sareh Eghtesad; Gabriele Eiben; Ulf Ekelund; Mohammad El-Khateeb; Jalila El Ati; Denise Eldemire-Shearer; Marie Eliasen; Paul Elliott; Reina Engle-Stone; Macia Enguerran; Rajiv T Erasmus; Raimund Erbel; Cihangir Erem; Louise Eriksen; Johan G Eriksson; Jorge Escobedo-de la Peña; Saeid Eslami; Ali Esmaeili; Alun Evans; David Faeh; Albina A Fakhretdinova; Caroline H Fall; Elnaz Faramarzi; Mojtaba Farjam; Victoria Farrugia Sant'Angelo; Farshad Farzadfar; Mohammad Reza Fattahi; Asher Fawwad; Francisco J Felix-Redondo; Trevor S Ferguson; Romulo A Fernandes; Daniel Fernández-Bergés; Daniel Ferrante; Thomas Ferrao; Marika Ferrari; Marco M Ferrario; Catterina Ferreccio; Eldridge Ferrer; Jean Ferrieres; Thamara Hubler Figueiró; Anna Fijalkowska; Günther Fink; Krista Fischer; Leng Huat Foo; Maria Forsner; Heba M Fouad; Damian K Francis; Maria do Carmo Franco; Ruth Frikke-Schmidt; Guillermo Frontera; Flavio D Fuchs; Sandra C Fuchs; Isti I Fujiati; Yuki Fujita; Matsuda Fumihiko; Takuro Furusawa; Zbigniew Gaciong; Mihai Gafencu; Andrzej Galbarczyk; Henrike Galenkamp; Daniela Galeone; Myriam Galfo; Fabio Galvano; Jingli Gao; Manoli Garcia-de-la-Hera; Marta García-Solano; Dickman Gareta; Sarah P Garnett; Jean-Michel Gaspoz; Magda Gasull; Adroaldo Cesar Araujo Gaya; Anelise Reis Gaya; Andrea Gazzinelli; Ulrike Gehring; Harald Geiger; Johanna M Geleijnse; Ali Ghanbari; Erfan Ghasemi; Oana-Florentina Gheorghe-Fronea; Simona Giampaoli; Francesco Gianfagna; Tiffany K Gill; Jonathan Giovannelli; Glen Gironella; Aleksander Giwercman; Konstantinos Gkiouras; Justyna Godos; Sibel Gogen; Marcel Goldberg; Rebecca A Goldsmith; David Goltzman; Santiago F Gómez; Aleksandra Gomula; Bruna Goncalves Cordeiro da Silva; Helen Gonçalves; David A Gonzalez-Chica; Marcela Gonzalez-Gross; Margot González-Leon; Juan P González-Rivas; Clicerio González-Villalpando; María-Elena González-Villalpando; Angel R Gonzalez; Frederic Gottrand; Antonio Pedro Graça; Sidsel Graff-Iversen; Dušan Grafnetter; Aneta Grajda; Maria G Grammatikopoulou; Ronald D Gregor; Tomasz Grodzicki; Else Karin Grøholt; Anders Grøntved; Giuseppe Grosso; Gabriella Gruden; Dongfeng Gu; Emanuela Gualdi-Russo; Pilar Guallar-Castillón; Andrea Gualtieri; Elias F Gudmundsson; Vilmundur Gudnason; Ramiro Guerrero; Idris Guessous; Andre L Guimaraes; Martin C Gulliford; Johanna Gunnlaugsdottir; Marc J Gunter; Xiu-Hua Guo; Yin Guo; Prakash C Gupta; Rajeev Gupta; Oye Gureje; Beata Gurzkowska; Enrique Gutiérrez-González; Laura Gutierrez; Felix Gutzwiller; Seongjun Ha; Farzad Hadaegh; Charalambos A Hadjigeorgiou; Rosa Haghshenas; Hamid Hakimi; Jytte Halkjær; Ian R Hambleton; Behrooz Hamzeh; Dominique Hange; Abu AM Hanif; Sari Hantunen; Jie Hao; Rachakulla Hari Kumar; Seyed Mohammad Hashemi-Shahri; Maria Hassapidou; Jun Hata; Teresa Haugsgjerd; Jiang He; Yuan He; Yuna He; Regina Heidinger-Felso; Mirjam Heinen; Tatjana Hejgaard; Marleen Elisabeth Hendriks; Rafael dos Santos Henrique; Ana Henriques; Leticia Hernandez Cadena; Sauli Herrala; Victor M Herrera; Isabelle Herter-Aeberli; Ramin Heshmat; Allan G Hill; Sai Yin Ho; Suzanne C Ho; Michael Hobbs; Michelle Holdsworth; Reza Homayounfar; Clara Homs; Wilma M Hopman; Andrea RVR Horimoto; Claudia M Hormiga; Bernardo L Horta; Leila Houti; Christina Howitt; Thein Thein Htay; Aung Soe Htet; Maung Maung Than Htike; Yonghua Hu; José María Huerta; Ilpo Tapani Huhtaniemi; Laetitia Huiart; Constanta Huidumac Petrescu; Martijn Huisman; Abdullatif Husseini; Chinh Nguyen Huu; Inge Huybrechts; Nahla Hwalla; Jolanda Hyska; Licia Iacoviello; Jesús M Ibarluzea; Mohsen M Ibrahim; Norazizah Ibrahim Wong; M Arfan Ikram; Violeta Iotova; Vilma E Irazola; Takafumi Ishida; Muhammad Islam; Sheikh Mohammed Shariful Islam; Masanori Iwasaki; Jeremy M Jacobs; Hashem Y Jaddou; Tazeen Jafar; Kenneth James; Kazi M Jamil; Konrad Jamrozik; Imre Janszky; Edward Janus; Juel Jarani; Marjo-Riitta Jarvelin; Grazyna Jasienska; Ana Jelakovic; Bojan Jelakovic; Garry Jennings; Anjani Kumar Jha; Chao Qiang Jiang; Ramon O Jimenez; Karl-Heinz Jöckel; Michel Joffres; Mattias Johansson; Jari J Jokelainen; Jost B Jonas; Jitendra Jonnagaddala; Torben Jørgensen; Pradeep Joshi; Farahnaz Joukar; Dragana P Jovic; Jacek J Jóźwiak; Anne Juolevi; Gregor Jurak; Iulia Jurca Simina; Vesna Juresa; Rudolf Kaaks; Felix O Kaducu; Anthony Kafatos; Eero O Kajantie; Zhanna Kalmatayeva; Ofra Kalter-Leibovici; Yves Kameli; Freja B Kampmann; Kodanda R Kanala; Srinivasan Kannan; Efthymios Kapantais; Argyro Karakosta; Line L Kårhus; Khem B Karki; Marzieh Katibeh; Joanne Katz; Peter T Katzmarzyk; Jussi Kauhanen; Prabhdeep Kaur; Maryam Kavousi; Gyulli M Kazakbaeva; Ulrich Keil; Lital Keinan Boker; Sirkka Keinänen-Kiukaanniemi; Roya Kelishadi; Cecily Kelleher; Han CG Kemper; Andre P Kengne; Maryam Keramati; Alina Kerimkulova; Mathilde Kersting; Timothy Key; Yousef Saleh Khader; Davood Khalili; Kay-Tee Khaw; Bahareh Kheiri; Motahareh Kheradmand; Alireza Khosravi; Ilse MSL Khouw; Ursula Kiechl-Kohlendorfer; Stefan Kiechl; Japhet Killewo; Dong Wook Kim; Hyeon Chang Kim; Jeongseon Kim; Jenny M Kindblom; Heidi Klakk; Magdalena Klimek; Jeannette Klimont; Jurate Klumbiene; Michael Knoflach; Bhawesh Koirala; Elin Kolle; Patrick Kolsteren; Jürgen König; Raija Korpelainen; Paul Korrovits; Magdalena Korzycka; Jelena Kos; Seppo Koskinen; Katsuyasu Kouda; Viktoria A Kovacs; Sudhir Kowlessur; Slawomir Koziel; Jana Kratenova; Wolfgang Kratzer; Susi Kriemler; Peter Lund Kristensen; Steiner Krokstad; Daan Kromhout; Herculina S Kruger; Ruzena Kubinova; Renata Kuciene; Urho M Kujala; Enisa Kujundzic; Zbigniew Kulaga; R Krishna Kumar; Marie Kunešová; Pawel Kurjata; Yadlapalli S Kusuma; Kari Kuulasmaa; Catherine Kyobutungi; Quang Ngoc La; Fatima Zahra Laamiri; Tiina Laatikainen; Carl Lachat; Youcef Laid; Tai Hing Lam; Christina-Paulina Lambrinou; Edwige Landais; Vera Lanska; Georg Lappas; Bagher Larijani; Tint Swe Latt; Laura Lauria; Maria Lazo-Porras; Gwenaëlle Le Coroller; Khanh Le Nguyen Bao; Agnès Le Port; Tuyen D Le; Jeannette Lee; Jeonghee Lee; Paul H Lee; Nils Lehmann; Terho Lehtimäki; Daniel Lemogoum; Naomi S Levitt; Yanping Li; Merike Liivak; Christa L Lilly; Wei-Yen Lim; M Fernanda Lima-Costa; Hsien-Ho Lin; Xu Lin; Yi-Ting Lin; Lars Lind; Allan Linneberg; Lauren Lissner; Mieczyslaw Litwin; Lijuan Liu; Wei-Cheng Lo; Helle-Mai Loit; Khuong Quynh Long; Luis Lopes; Oscar Lopes; Esther Lopez-Garcia; Tania Lopez; Paulo A Lotufo; José Eugenio Lozano; Janice L Lukrafka; Dalia Luksiene; Annamari Lundqvist; Robert Lundqvist; Nuno Lunet; Charles Lunogelo; Michala Lustigová; Edyta Łuszczki; Guansheng Ma; Jun Ma; Xu Ma; George LL Machado-Coelho; Aristides M Machado-Rodrigues; Luisa M Macieira; Ahmed A Madar; Stefania Maggi; Dianna J Magliano; Sara Magnacca; Emmanuella Magriplis; Gowri Mahasampath; Bernard Maire; Marjeta Majer; Marcia Makdisse; Päivi Mäki; Fatemeh Malekzadeh; Reza Malekzadeh; Rahul Malhotra; Kodavanti Mallikharjuna Rao; Sofia K Malyutina; Lynell V Maniego; Yannis Manios; Jim I Mann; Fariborz Mansour-Ghanaei; Enzo Manzato; Paula Margozzini; Anastasia Markaki; Oonagh Markey; Eliza Markidou Ioannidou; Pedro Marques-Vidal; Larissa Pruner Marques; Jaume Marrugat; Yves Martin-Prevel; Rosemarie Martin; Reynaldo Martorell; Eva Martos; Katharina Maruszczak; Stefano Marventano; Luis P Mascarenhas; Shariq R Masoodi; Ellisiv B Mathiesen; Prashant Mathur; Alicia Matijasevich; Tandi E Matsha; Christina Mavrogianni; Artur Mazur; Jean Claude N Mbanya; Shelly R McFarlane; Stephen T McGarvey; Martin McKee; Stela McLachlan; Rachael M McLean; Scott B McLean; Breige A McNulty; Sounnia Mediene Benchekor; Jurate Medzioniene; Parinaz Mehdipour; Kirsten Mehlig; Amir Houshang Mehrparvar; Aline Meirhaeghe; Jørgen Meisfjord; Christa Meisinger; Ana Maria B Menezes; Geetha R Menon; Gert BM Mensink; Maria Teresa Menzano; Alibek Mereke; Indrapal I Meshram; Andres Metspalu; Haakon E Meyer; Jie Mi; Kim F Michaelsen; Nathalie Michels; Kairit Mikkel; Karolina Milkowska; Jody C Miller; Cláudia S Minderico; GK Mini; Juan Francisco Miquel; Mohammad Reza Mirjalili; Daphne Mirkopoulou; Erkin Mirrakhimov; Marjeta Mišigoj-Durakovic; Antonio Mistretta; Veronica Mocanu; Pietro A Modesti; Sahar Saeedi Moghaddam; Bahram Mohajer; Mostafa K Mohamed; Shukri F Mohamed; Kazem Mohammad; Zahra Mohammadi; Noushin Mohammadifard; Reza Mohammadpourhodki; Viswanathan Mohan; Salim Mohanna; Muhammad Fadhli Mohd Yusoff; Iraj Mohebbi; Farnam Mohebi; Marie Moitry; Drude Molbo; Line T Møllehave; Niels C Møller; Dénes Molnár; Amirabbas Momenan; Charles K Mondo; Michele Monroy-Valle; Eric Monterrubio-Flores; Kotsedi Daniel K Monyeki; Jin Soo Moon; Mahmood Moosazadeh; Leila B Moreira; Alain Morejon; Luis A Moreno; Karen Morgan; Suzanne N Morin; Erik Lykke Mortensen; George Moschonis; Malgorzata Mossakowska; Aya Mostafa; Anabela Mota-Pinto; Jorge Mota; Mohammad Esmaeel Motlagh; Jorge Motta; Marcos André Moura-dos-Santos; Malay K Mridha; Kelias P Msyamboza; Thet Thet Mu; Magdalena Muc; Boban Mugoša; Maria L Muiesan; Parvina Mukhtorova; Martina Müller-Nurasyid; Neil Murphy; Jaakko Mursu; Elaine M Murtagh; Kamarul Imran Musa; Sanja Music Milanovic; Vera Musil; Norlaila Mustafa; Iraj Nabipour; Shohreh Naderimagham; Gabriele Nagel; Balkish M Naidu; Farid Najafi; Harunobu Nakamura; Jana Námešná; Ei Ei K Nang; Vinay B Nangia; Martin Nankap; Sameer Narake; Paola Nardone; Matthias Nauck; William A Neal; Azim Nejatizadeh; Chandini Nekkantti; Keiu Nelis; Liis Nelis; Ilona Nenko; Martin Neovius; Flavio Nervi; Chung T Nguyen; Nguyen D Nguyen; Quang Ngoc Nguyen; Ramfis E Nieto-Martínez; Yury P Nikitin; Guang Ning; Toshiharu Ninomiya; Sania Nishtar; Marianna Noale; Oscar A Noboa; Helena Nogueira; Teresa Norat; Maria Nordendahl; Børge G Nordestgaard; Davide Noto; Natalia Nowak-Szczepanska; Mohannad Al Nsour; Irfan Nuhoglu; Eha Nurk; Terence W O'Neill; Dermot O'Reilly; Galina Obreja; Caleb Ochimana; Angélica M Ochoa-Avilés; Eiji Oda; Kyungwon Oh; Kumiko Ohara; Claes Ohlsson; Ryutaro Ohtsuka; Örn Olafsson; Maria Teresa A Olinto; Isabel O Oliveira; Mohd Azahadi Omar; Altan Onat; Sok King Ong; Lariane M Ono; Pedro Ordunez; Rui Ornelas; Ana P Ortiz; Pedro J Ortiz; Merete Osler; Clive Osmond; Sergej M Ostojic; Afshin Ostovar; Johanna A Otero; Kim Overvad; Ellis Owusu-Dabo; Fred Michel Paccaud; Cristina Padez; Ioannis Pagkalos; Elena Pahomova; Karina Mary de Paiva; Andrzej Pajak; Domenico Palli; Alberto Palloni; Luigi Palmieri; Wen-Harn Pan; Songhomitra Panda-Jonas; Arvind Pandey; Francesco Panza; Dimitrios Papandreou; Soon-Woo Park; Suyeon Park; Winsome R Parnell; Mahboubeh Parsaeian; Ionela M Pascanu; Patrick Pasquet; Nikhil D Patel; Ivan Pecin; Mangesh S Pednekar; Nasheeta Peer; Gao Pei; Sergio Viana Peixoto; Markku Peltonen; Alexandre C Pereira; Marco A Peres; Napoleón Pérez-Farinós; Cynthia M Pérez; Valentina Peterkova; Annette Peters; Astrid Petersmann; Janina Petkeviciene; Ausra Petrauskiene; Emanuela Pettenuzzo; Niloofar Peykari; Son Thai Pham; Rafael N Pichardo; Daniela Pierannunzio; Iris Pigeot; Hynek Pikhart; Aida Pilav; Lorenza Pilotto; Francesco Pistelli; Freda Pitakaka; Aleksandra Piwonska; Andreia N Pizarro; Pedro Plans-Rubió; Bee Koon Poh; Hermann Pohlabeln; Raluca M Pop; Stevo R Popovic; Miquel Porta; Georg Posch; Anil Poudyal; Dimitrios Poulimeneas; Hamed Pouraram; Farhad Pourfarzi; Akram Pourshams; Hossein Poustchi; Rajendra Pradeepa; Alison J Price; Jacqueline F Price; Rui Providencia; Jardena J Puder; Iveta Pudule; Soile E Puhakka; Maria Puiu; Margus Punab; Radwan F Qasrawi; Mostafa Qorbani; Tran Quoc Bao; Ivana Radic; Ricardas Radisauskas; Salar Rahimikazerooni; Mahfuzar Rahman; Mahmudur Rahman; Olli Raitakari; Manu Raj; Ellina Rakhimova; Sherali Rakhmatulloev; Ivo Rakovac; Sudha Ramachandra Rao; Ambady Ramachandran; Jacqueline Ramke; Elisabete Ramos; Rafel Ramos; Lekhraj Rampal; Sanjay Rampal; Vayia Rarra; Ramon A Rascon-Pacheco; Mette Rasmussen; Cassiano Ricardo Rech; Josep Redon; Paul Ferdinand M Reganit; Valéria Regecová; Luis Revilla; Abbas Rezaianzadeh; Lourdes Ribas-Barba; Robespierre Ribeiro; Elio Riboli; Adrian Richter; Fernando Rigo; Natascia Rinaldo; Tobias F Rinke de Wit; Ana Rito; Raphael M Ritti-Dias; Juan A Rivera; Cynthia Robitaille; Romana Roccaldo; Daniela Rodrigues; Fernando Rodríguez-Artalejo; María del Cristo Rodriguez-Perez; Laura A Rodríguez-Villamizar; Ulla Roggenbuck; Rosalba Rojas-Martinez; Nipa Rojroongwasinkul; Dora Romaguera; Elisabetta L Romeo; Rafaela V Rosario; Annika Rosengren; Ian Rouse; Joel GR Roy; Adolfo Rubinstein; Frank J Rühli; Jean-Bernard Ruidavets; Blanca Sandra Ruiz-Betancourt; Maria Ruiz-Castell; Emma Ruiz Moreno; Iuliia A Rusakova; Kenisha Russell Jonsson; Paola Russo; Petra Rust; Marcin Rutkowski; Charumathi Sabanayagam; Elena Sacchini; Harshpal S Sachdev; Alireza Sadjadi; Ali Reza Safarpour; Saeid Safiri; Nader Saki; Benoit Salanave; Eduardo Salazar Martinez; Diego Salmerón; Veikko Salomaa; Jukka T Salonen; Massimo Salvetti; Margarita Samoutian; Jose Sánchez-Abanto; Sandjaja; Susana Sans; Loreto Santa Marina; Diana A Santos; Ina S Santos; Lèlita C Santos; Maria Paula Santos; Osvaldo Santos; Rute Santos; Sara Santos Sanz; Jouko L Saramies; Luis B Sardinha; Nizal Sarrafzadegan; Thirunavukkarasu Sathish; Kai-Uwe Saum; Savvas Savva; Mathilde Savy; Norie Sawada; Mariana Sbaraini; Marcia Scazufca; Beatriz D Schaan; Angelika Schaffrath Rosario; Herman Schargrodsky; Anja Schienkiewitz; Sabine Schipf; Carsten O Schmidt; Ida Maria Schmidt; Peter Schnohr; Ben Schöttker; Sara Schramm; Stine Schramm; Helmut Schröder; Constance Schultsz; Aletta E Schutte; Aye Aye Sein; Rusidah Selamat; Vedrana Sember; Abhijit Sen; Idowu O Senbanjo; Sadaf G Sepanlou; Victor Sequera; Luis Serra-Majem; 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Angela Spinelli; Igor Spiroski; Jan A Staessen; Hanspeter Stamm; Maria G Stathopoulou; Kaspar Staub; Bill Stavreski; Jostein Steene-Johannessen; Peter Stehle; Aryeh D Stein; George S Stergiou; Jochanan Stessman; Ranko Stevanovic; Jutta Stieber; Doris Stöckl; Tanja Stocks; Jakub Stokwiszewski; Ekaterina Stoyanova; Gareth Stratton; Karien Stronks; Maria Wany Strufaldi; Lela Sturua; Ramón Suárez-Medina; Machi Suka; Chien-An Sun; Johan Sundström; Yn-Tz Sung; Jordi Sunyer; Paibul Suriyawongpaisal; Boyd A Swinburn; Rody G Sy; Holly E Syddall; René Charles Sylva; Moyses Szklo; Lucjan Szponar; E Shyong Tai; Mari-Liis Tammesoo; Abdonas Tamosiunas; Eng Joo Tan; Xun Tang; Maya Tanrygulyyeva; Frank Tanser; Yong Tao; Mohammed Rasoul Tarawneh; Jakob Tarp; Carolina B Tarqui-Mamani; Radka Taxová Braunerová; Anne Taylor; Julie Taylor; Félicité Tchibindat; William R Tebar; Grethe S Tell; Tania Tello; Yih Chung Tham; KR Thankappan; Holger Theobald; Xenophon Theodoridis; Lutgarde Thijs; Nihal Thomas; Betina H Thuesen; Lubica Tichá; Erik J Timmermans; Anne Tjonneland; Hanna K Tolonen; Janne S Tolstrup; Murat Topbas; Roman Topór-Madry; Liv Elin Torheim; María José Tormo; Michael J Tornaritis; Maties Torrent; Laura Torres-Collado; Stefania Toselli; Giota Touloumi; Pierre Traissac; Thi Tuyet-Hanh Tran; Dimitrios Trichopoulos; Antonia Trichopoulou; Oanh TH Trinh; Atul Trivedi; Lechaba Tshepo; Maria Tsigga; Shoichiro Tsugane; Azaliia M Tuliakova; Marshall K Tulloch-Reid; Fikru Tullu; Tomi-Pekka Tuomainen; Jaakko Tuomilehto; Maria L Turley; Gilad Twig; Per Tynelius; Themistoklis Tzotzas; Christophe Tzourio; Peter Ueda; Eunice Ugel; Flora AM Ukoli; Hanno Ulmer; Belgin Unal; Zhamyila Usupova; Hannu MT Uusitalo; Nalan Uysal; Justina Vaitkeviciute; Gonzalo Valdivia; Susana Vale; Damaskini Valvi; Rob M van Dam; Johan Van der Heyden; Yvonne T van der Schouw; Koen Van Herck; Hoang Van Minh; Natasja M Van Schoor; Irene GM van Valkengoed; Dirk Vanderschueren; Diego Vanuzzo; Anette Varbo; Gregorio Varela-Moreiras; Patricia Varona-Pérez; Senthil K Vasan; Tomas Vega; Toomas Veidebaum; Gustavo Velasquez-Melendez; Biruta Velika; Giovanni Veronesi; WM Monique Verschuren; Cesar G Victora; Giovanni Viegi; Lucie Viet; Salvador Villalpando; Paolo Vineis; Jesus Vioque; Jyrki K Virtanen; Marjolein Visser; Sophie Visvikis-Siest; Bharathi Viswanathan; Mihaela Vladulescu; Tiina Vlasoff; Dorja Vocanec; Peter Vollenweider; Henry Völzke; Ari Voutilainen; Sari Voutilainen; Martine Vrijheid; Tanja GM Vrijkotte; Alisha N Wade; Aline Wagner; Thomas Waldhör; Janette Walton; Elvis OA Wambiya; Wan Mohamad Wan Bebakar; Wan Nazaimoon Wan Mohamud; Rildo de Souza Wanderley Júnior; Ming-Dong Wang; Ningli Wang; Qian Wang; Xiangjun Wang; Ya Xing Wang; Ying-Wei Wang; S Goya Wannamethee; Nicholas Wareham; Adelheid Weber; Niels Wedderkopp; Deepa Weerasekera; Daniel Weghuber; Wenbin Wei; Aneta Weres; Bo Werner; Peter H Whincup; Kurt Widhalm; Indah S Widyahening; Andrzej Wiecek; Rainford J Wilks; Johann Willeit; Peter Willeit; Julianne Williams; Tom Wilsgaard; Bogdan Wojtyniak; Roy A Wong-McClure; Andrew Wong; Jyh Eiin Wong; Tien Yin Wong; Jean Woo; Mark Woodward; Frederick C Wu; Jianfeng Wu; Li Juan Wu; Shouling Wu; Haiquan Xu; Liang Xu; Nor Azwany Yaacob; Uruwan Yamborisut; Weili Yan; Ling Yang; Xiaoguang Yang; Yang Yang; Nazan Yardim; Mehdi Yaseri; Tabara Yasuharu; Xingwang Ye; Panayiotis K Yiallouros; Moein Yoosefi; Akihiro Yoshihara; Qi Sheng You; San-Lin You; Novie O Younger-Coleman; Safiah Md Yusof; Ahmad Faudzi Yusoff; Luciana Zaccagni; Vassilis Zafiropulos; Ahmad A Zainuddin; Seyed Rasoul Zakavi; Farhad Zamani; Sabina Zambon; Antonis Zampelas; Hana Zamrazilová; Maria Elisa Zapata; Abdul Hamid Zargar; Ko Ko Zaw; Tomasz Zdrojewski; Kristyna Zejglicova; Tajana Zeljkovic Vrkic; Yi Zeng; Luxia Zhang; Zhen-Yu Zhang; Dong Zhao; Ming-Hui Zhao; Wenhua Zhao; Shiqi Zhen; Wei Zheng; Yingfeng Zheng; Bekbolat Zholdin; Maigeng Zhou; Dan Zhu; Marie Zins; Emanuel Zitt; Yanina Zocalo; Julio Zuñiga Cisneros; Monika Zuziak; Majid Ezzati; Sarah Filippi
  eLife, 10, eLife Sciences Publications, Ltd, 09 Mar. 2021, [Peer-reviewed]
  Scientific journal, From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
• Preliminary investigation of family caregiver burden and oral care provided to homebound older patients.
  Yuki Ohara; Masanori Iwasaki; Keiko Motokawa; Hirohiko Hirano
  Clinical and experimental dental research, 7, 5, 840, 844, 08 Mar. 2021, [International Magazine]
  English, Scientific journal, OBJECTIVES: Family caregivers play an important role in maintaining the oral health of homebound older adults. Thus, this preliminary study investigated family caregivers' burdens and the oral care they provide to homebound older patients. MATERIAL AND METHODS: A cross-sectional survey was conducted. A questionnaire was distributed to 230 family caregivers of homebound older patients. We used the Japanese version of the Zarit Burden Interview (J-ZBI) to measure caregiver burden. The cut-off score for the J-ZBI was 21 points. Caregivers with a care burden score below 21 points formed the mild group, while those scoring 21 points or more were included in the moderate/severe group. The differences between the groups were examined. The implementation status of oral care was assessed by the amount of time caregivers spent providing oral care and related concerns. The degree of independence for homebound older patients was measured using the Barthel Index. Multiple logistic regression analyses were conducted to determine the factors associated with the severity of caregiver burden. RESULTS: A total of 114 caregivers returned the questionnaires by mail (response rate: 49.6%). The moderate/severe care burden group represented 80.7% of the caregivers. A multiple logistic regression analysis revealed that the level of patient independence and time spent performing oral care were significantly associated with the severity of caregiver burden. CONCLUSIONS: The results show that family caregivers experiencing high caregiver burden spent less time providing oral care than caregivers who reported less caregiver burden. Thus, support for oral health management provided by oral health professionals is considered necessary for family with a high caregiver burden of homebound older patients.
• Oral frailty and gait performance in community-dwelling older adults: findings from the Takashimadaira study.
  Masanori Iwasaki; Yutaka Watanabe; Keiko Motokawa; Maki Shirobe; Hiroki Inagaki; Yoshiko Motohashi; Yurie Mikami; Yu Taniguchi; Yosuke Osuka; Satoshi Seino; Hunkyung Kim; Hisashi Kawai; Ryota Sakurai; Ayako Edahiro; Yuki Ohara; Hirohiko Hirano; Shoji Shinkai; Shuichi Awata
  Journal of prosthodontic research, 65, 4, 467, 473, 22 Feb. 2021, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
  English, Scientific journal, PURPOSE: This cross-sectional study compared gait performance between community-dwelling older adults with and without accumulated deficits in oral health, defined as oral frailty. METHODS: A total of 1,082 individuals (439 men and 643 women; mean age, 77.1 years) from the Takashimadaira study were included in the current analysis. Based on a multifaceted oral health assessment, oral frailty was defined as having three or more of the following six components: (i) fewer teeth, (ii) low masticatory performance, (iii) low articulatory oral motor skills, (iv) low tongue pressure, (v) difficulties in eating, and (vi) swallowing. Eight gait parameters were assessed using an electronic walkway. Gait characteristics comparison between groups with and without oral frailty was performed using multiple linear regression models. Models were adjusted for age, sex, educational status, income, smoking, drinking, physical activity level, height, body mass index, comorbidities, and the presence of chronic pain. RESULTS: Oral frailty was observed in 227 (21.0%) participants. After adjusting for potential confounders, the participants with oral frailty had slower gait speed, shorter stride and step length, wider step width, and longer double support duration as well as higher variability of stride length and step length. CONCLUSIONS: Oral frailty was associated with poor gait performance among community-dwelling older adults.
• Low Dietary Variety and Diabetes Mellitus Are Associated with Frailty among Community-Dwelling Older Japanese Adults: A Cross-Sectional Study.
  Misato Hayakawa; Keiko Motokawa; Yurie Mikami; Kaori Yamamoto; Maki Shirobe; Ayako Edahiro; Masanori Iwasaki; Yuki Ohara; Yutaka Watanabe; Hisashi Kawai; Motonaga Kojima; Shuichi Obuchi; Yoshinori Fujiwara; Hunkyung Kim; Kazushige Ihara; Hiroki Inagaki; Shoji Shinkai; Shuichi Awata; Atsushi Araki; Hirohiko Hirano
  Nutrients, 13, 2, 16 Feb. 2021, [International Magazine]
  English, Scientific journal, The association between dietary diversity and frailty remains unknown in older people. We evaluated whether a limited dietary variety is associated with frailty in older adults with diabetes mellitus (DM). This cross-sectional investigation included 1357 adults (median age: 77 years, women: 61.3%). DM was determined by self-reporting, the Dietary Variety Score (DVS) was used to evaluate dietary variety, and the revised Japanese version of the Cardiovascular Health Study criteria evaluated frailty. Participants were divided into 4 groups: no DM/high DVS (non-DMHV), no DM/low DVS (non-DMLV), DM/high DVS (DMHV), and DM/low DVS (DMLV). The prevalence of frailty in each group was 3.6%, 6.7%, 6.7%, and 12.2%. After adjusting for covariates, logistic regression analysis revealed the highest odds ratio (OR) of frailty in the DMLV (non-DMLV, OR = 2.18 (95% confidence interval (CI): 1.25-3.83); DMHV, OR = 1.87 (95% CI: 0.63-5.52); DML, OR = 5.03 (95% CI: 2.05-12.35)). Another logistic regression analysis revealed that a low DVS and DM were independently associated with frailty. Both a low dietary variety and DM were independently related to frailty in older people and the combination increased the prevalence of frailty. These findings suggest that high dietary variety could be important for the prevention of frailty in people with DM.
• Relationship between Mortality and Oral Function of Older People Requiring Long-Term Care in Rural Areas of Japan: A Four-Year Prospective Cohort Study.
  Shiho Morishita; Yuki Ohara; Masanori Iwasaki; Ayako Edahiro; Keiko Motokawa; Maki Shirobe; Junichi Furuya; Yutaka Watanabe; Takeo Suga; Yayoi Kanehisa; Akitugu Ohuchi; Hirohiko Hirano
  International journal of environmental research and public health, 18, 4, 10 Feb. 2021, [International Magazine]
  English, Scientific journal, Oral ingestion influences the life sustenance, quality of life, and dignity of older adults. Thus, it is an important issue in medical care and the welfare of older adults. The purpose of this four-year prospective cohort study was to investigate the relationship between mortality and oral function among older adults who required long-term care and were living in different settings in a rural area of Japan. This study included 289 participants aged 65 and older who required long-term care and lived in the former Omorimachi area in Yokote City, Akita Prefecture, located in northern Japan. Following the baseline survey, mortality data were collected over four years; 102 participants (35.3%) died during that time. A significant difference was noted in the overall survival rates between the groups with good and deterioration of oral function such as oral dryness, rinsing ability, swallowing function, and articulation, based on Log-rank test results. After adjusting for various potential confounders using Cox proportional-hazards regression, oral dryness (HR: 1.83, 95% confidence interval: 1.12-3.00) was significantly associated with mortality within four years. This study revealed that oral dryness influences the life prognosis of older adults who receive long-term care in different settings.
• Relationship between Chewing Ability and Nutritional Status in Japanese Older Adults: A Cross-Sectional Study.
  Keiko Motokawa; Yurie Mikami; Maki Shirobe; Ayako Edahiro; Yuki Ohara; Masanori Iwasaki; Yutaka Watanabe; Hisashi Kawai; Takeshi Kera; Shuichi Obuchi; Yoshinori Fujiwara; Kazushige Ihara; Hirohiko Hirano
  International journal of environmental research and public health, 18, 3, 29 Jan. 2021, [International Magazine]
  English, Scientific journal, OBJECTIVES: This study aimed to determine the relationship between objective chewing ability and the nutritional status of Japanese community-dwelling elders. DESIGN: A cross-sectional study. PARTICIPANTS: A total of 509 community-dwelling elders living in the Tokyo metropolitan area participated in a comprehensive survey conducted in October 2013. MEASUREMENTS: The basic characteristics were sex, age, and body mass index. Undernutrition was examined through serum albumin levels. Chewing ability was examined through color-changeable xylitol gum by evaluating the color changes in chewing gum. Nutritional intake was examined using the semi-quantitative food frequency questionnaire. RESULTS: In the poor chewing ability group, all nutrient intake levels were significantly low, except for carbohydrates, and intake levels for all food groups were significantly low, except for cereals, confectionery, sugars, seasonings, and spices. Additionally, after adjusting for covariates for sex, age, Tokyo Metropolitan Institute of Gerontology-Index of Competence (TMIG-IC) score, Mini-Mental State Examination (MMSE) score, body mass index (BMI), stroke, number of functional teeth, energy intake, and protein intake, chewing ability was found to be significantly associated with undernutrition. CONCLUSION: We concluded that chewing ability was closely associated with nutrient and different food groups' intake, as well as undernutrition, among Japanese community-dwelling elders. Thus, to ensure comprehensive nutritional management, nutritionists and dentists should collaborate when treating the same patients.
• Relationship between the rate of a decreased oral function and the nutrient intake in community-dwelling older persons: An examination using oral function-related items in a questionnaire for latter-stage elderly people
  Yoshihiro Kugimiya; Keiko Motokawa; Kaori Yamamoto; Misato Hayakawa; Yurie Mikami; Masanori Iwasaki; Yuki Ohara; Maki Shirobe; Ayako Edahiro; Yutaka Watanabe; Shuichi Obuchi; Hisashi Kawai; Takeshi Kera; Yoshinori Fujiwara; Kazushige Ihara; Hunkyung Kim; Hirohiko Hirano
  Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 58, 1, 91, 100, The Japan Geriatrics Society, 25 Jan. 2021
  Scientific journal
• A 5-year longitudinal association between dietary fermented soya bean (natto) intake and tooth loss through bone mineral density in postmenopausal women: The Yokogoshi cohort study.
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Toshiko Saito; Kaori Kitamura; Toshihiro Ansai; Kazutoshi Nakamura
  Gerodontology, 38, 3, 267, 275, 04 Jan. 2021, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, OBJECTIVE: In this 5-year cohort study, we aimed to determine whether the intake of natto, a fermented soya bean food product, has an indirect effect on tooth loss incidence through BMD changes among postmenopausal women. BACKGROUND: Evidence indicates (1) that natto has a beneficial effect on bone health and (2) that a decrease in bone mineral density (BMD) is associated with tooth loss. METHODS: The study recruited 435 postmenopausal women (average age = 64.2 years). Natto intake (exposure) was assessed at baseline using a food frequency questionnaire. Lumbar spine BMD and number of teeth were measured at baseline and 5-year follow-up. BMD change (mediator) and the number of teeth lost (outcome) over time were calculated. The mediation model consisted of these 3 variables. Mediation analysis was performed to test the indirect effect of the natto intake measured through BMD change on tooth loss. RESULTS: During the study, the mean number of teeth lost was 1.2 (standard deviation = 1.8), and the mean BMD decline was 2.5% (standard deviation = 7.1). After adjusting for potential confounders, increasing habitual natto intake was significantly indirectly associated with a lower incidence of tooth loss mediated by BMD change (incidence rate ratio of tooth loss among women with "≥1 pack/day" natto intake was 0.90 [95% confidence interval = 0.82-0.99] compared to those with natto consumption of "rarely"). CONCLUSIONS: Dietary natto intake is significantly indirectly associated with a lower incidence of tooth loss among postmenopausal women, and systemic bone density could be a mediator of this association.
• Nutritional status and body composition in cognitively impaired older persons living alone: The Takashimadaira study.
  Masanori Iwasaki; Keiko Motokawa; Yutaka Watanabe; Misato Hayakawa; Yurie Mikami; Maki Shirobe; Hiroki Inagaki; Ayako Edahiro; Yuki Ohara; Hirohiko Hirano; Shoji Shinkai; Shuichi Awata
  PloS one, 16, 11, e0260412, 2021, [International Magazine]
  English, Scientific journal, OBJECTIVES: To investigate nutritional status and body composition in cognitively impaired older persons living alone. METHODS: This cross-sectional study included 1051 older adults (633 women and 418 men, mean age: 77.1 years) from the Takashimadaira study. The study participants were categorized according to whether they lived alone, which was confirmed via questionnaire, and had cognitive impairment, which was defined as having a Mini Mental State Examination-Japanese score ≤23. Nutritional status was evaluated using the serum albumin level. The fat-free mass index (FFMI) was calculated based on anthropometric and body composition measurements. A logistic regression model with the outcome of a low serum albumin level (serum albumin <4 g/dL) and low FFMI (<16 kg/m2 in men and <14 kg/m2 in women) were used to analyze the data. RESULTS: The percentages of participants in the living alone (-)/cognitive impairment (-) group, the living alone (+)/cognitive impairment (-) group, the living alone (-)/cognitive impairment (+) group, and the living alone (+)/cognitive impairment (+) group were 54.8%, 37.3%, 5.6%, and 2.3%, respectively. Compared to the living alone (-)/cognitive impairment (-) group, the living alone (+)/cognitive impairment (+) group was more likely to have a low serum albumin level (adjusted odds ratio = 3.10, 95% confidence interval = 1.31 to 7.33) and low FFMI (adjusted odds ratio = 2.79, 95% confidence interval = 1.10 to 7.06) after adjusting for potential confounders. CONCLUSION: Cognitively impaired older adults living alone had poorer nutrition than cognitively normal and cohabitating persons in this study. Our results highlight the importance of paying extra attention to nutritional status for this group of community-dwelling older adults.
• Evaluation of the ability of the trypsin-like peptidase activity assay to detect severe periodontitis.
  Masanori Iwasaki; Michihiko Usui; Wataru Ariyoshi; Keisuke Nakashima; Yoshie Nagai-Yoshioka; Maki Inoue; Kaoru Kobayashi; Tatsuji Nishihara
  PloS one, 16, 8, e0256538, 2021, [International Magazine]
  English, Scientific journal, OBJECTIVES: N-benzoyl-DL-arginine peptidase (trypsin-like peptidase) is specifically produced by certain strains of periodontitis-associated bacteria. We aimed to examine the effectiveness of an objectively quantified trypsin-like peptidase activity assay (TLP-AA) for detecting severe periodontitis. METHODS: The study population included 347 adults (108 men and 239 women; average age, 43.3 years) who underwent a full-mouth periodontal examination. Specimens for the TLP-AA were obtained using tongue swabs. Using a color reader, the TLP-AA results were obtained as a* values, with higher positive a* values indicating an increased intense enzymatic activity. The predictive validity of the TLP-AA results for severe periodontitis was assessed using receiver operating characteristic curve analysis and the periodontitis case definition provided by the Centers for Disease Control and Prevention/American Academy of Periodontology as the gold standard. Furthermore, multivariable logistic regression analyses were performed to predict severe periodontitis using the TLP-AA results and health characteristics, as the exposure variables. RESULTS: Severe periodontitis was observed in 5.2% of the participants. TLP-AA had high diagnostic accuracy for severe periodontitis, with an area under the curve of 0.83 (95% confidence interval [CI]: 0.75-0.92). The cut-off score for the a* value that best differentiated individuals with severe periodontitis was 0.09, with a sensitivity of 83% and specificity of 77%. Multivariable logistic regression analyses revealed that the TLP-AA results were significantly associated with severe periodontitis after adjusting for health characteristics (adjusted odds ratios: 1.90 [95% CI: 1.37-2.62] for the a* value). CONCLUSIONS: Objectively quantified TLP-AA results are potentially useful for detecting severe periodontitis in epidemiological surveillance.
• 地域在住高齢者における口腔機能低下の有訴者率と栄養素等摂取量の関連 後期高齢者の質問票を構成する口腔機能関連項目を用いた検討
  釘宮 嘉浩; 本川 佳子; 山本 かおり; 早川 美知; 三上 友里江; 岩崎 正則; 小原 由紀; 白部 麻樹; 枝広 あや子; 渡邊 裕; 大渕 修一; 河合 恒; 解良 武士; 藤原 佳典; 井原 一成; 金 憲経; 平野 浩彦
  日本老年医学会雑誌, 58, 1, 91, 100, (一社)日本老年医学会, Jan. 2021
  Japanese
• Dentition status and 10-year higher-level functional capacity trajectories in older adults.
  Masanori Iwasaki; Akihiro Yoshihara
  Geriatrics & gerontology international, 21, 1, 48, 53, Jan. 2021, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
  English, Scientific journal, AIM: The effect of dentition status on higher-level functional capacity patterns over time remains unclear. We aimed to identify distinct higher-level functional capacity trajectories in individuals aged 70-80 years, and examine whether dentition status at 70 years predicted the trajectory. METHODS: The study included 551 community-dwelling adults aged 70 years at baseline. Higher-level functional capacity was measured using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC) up to the age of 80 years. A higher TMIG-IC score indicated a higher level of competence. Group-based trajectory modeling was used to identify distinct TMIG-IC trajectories. The number of teeth, use of dentures, sex and education were added as baseline group membership predictors. Dental visits, health behaviors, body mass index and comorbidities during observation were added as time-varying covariates. RESULTS: Three TMIG-IC trajectories were identified: "high/stable" (65.3%), "middle/decline" (24.5%) and "low/decline" (10.2%). A lower number of teeth and non-denture use were associated with increased odds of a low/decline trajectory relative to a high/stable trajectory (odds ratio 1.09, 95% confidence interval 1.04-1.14 [per one decrease] and odds ratio 3.96, 95% confidence interval 1.54-10.16, respectively). CONCLUSIONS: Older adults with fewer teeth and those without dentures at the age of 70 years were more likely to follow a trajectory toward functional decline with low baseline TMIG-IC scores, which further declines by the age of 80 years. These findings suggest that preserving natural teeth later in life, as well as using dentures, could contribute toward maintaining a higher-level functional competence. Geriatr Gerontol Int 2021; 21: 48-53.
• A Two-Year Longitudinal Study of the Association between Oral Frailty and Deteriorating Nutritional Status among Community-Dwelling Older Adults.
  Masanori Iwasaki; Keiko Motokawa; Yutaka Watanabe; Maki Shirobe; Hiroki Inagaki; Ayako Edahiro; Yuki Ohara; Hirohiko Hirano; Shoji Shinkai; Shuichi Awata
  International journal of environmental research and public health, 18, 1, 30 Dec. 2020, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, BACKGROUND: Limited longitudinal studies exist to evaluate whether poor oral health and functions affect the incidence of deteriorating nutritional status. We investigated if there were longitudinal associations between oral frailty, defined as accumulated deficits in oral health, and deteriorating nutritional status among community-dwelling older adults. METHODS: The study population consisted of 191 men and 275 women (mean age, 76.4 years) from the Takashimadaira Study. Multifaced oral health assessment was performed at baseline, and oral frailty was defined as having ≥3 of the following six components: fewer teeth, low masticatory performance, low articulatory oral motor skill, low tongue pressure, and difficulties in chewing and swallowing. Nutritional status assessment was performed at baseline and two-year follow-up using the Mini Nutritional Assessment®-Short Form (MNA®-SF). Deteriorating nutritional status was defined as a decline in the nutritional status categories based on the MNA®-SF score during the study period. The association between oral frailty and deteriorating nutritional status was assessed using logistic regression analyses. RESULTS: Oral frailty was observed in 67 (14.4%) participants at baseline. During the study, 58 (12.4%) participants exhibited deteriorating nutritional status. After adjusting for potential confounders, oral frailty was significantly associated with deteriorating nutritional status (adjusted odds ratio, 2.24; 95% confidence interval, 1.08-4.63). CONCLUSION: Community-dwelling older adults with oral frailty had an increased risk of deteriorating nutritional status.
• [Assessment of participation and its associated lifestyle factors in the 2016 National Survey of Dental Diseases: an analysis through record linkage with National Health and Nutrition Survey].
  Yuichi Ando; Nayu Ikeda; Nobuo Nishi; Rumi Tano; Masanori Iwasaki; Hiroko Miura
  [Nihon koshu eisei zasshi] Japanese journal of public health, 19 Dec. 2020, [Domestic magazines]
  Japanese, Scientific journal
• Association between anorexia and hyposalivation in community-dwelling older adults in Japan: a 6-year longitudinal study.
  Yuki Ohara; Hisashi Kawai; Maki Shirobe; Keiko Motokawa; Yoshinori Fujiwara; Hunkyung Kim; Kazushige Ihara; Shuichi Obuchi; Ayako Edahiro; Masanori Iwasaki; Yutaka Watanabe; Hirohiko Hirano
  BMC geriatrics, 20, 1, 504, 504, 25 Nov. 2020, [International Magazine]
  English, Scientific journal, BACKGROUND: Hyposalivation is associated with the nutritional status. Anorexia of ageing, defined as an age-related decrease in appetite and food intake, presents even in healthy adults and is considered an independent predictor of malnutrition, frailty, and mortality. However, the relationship between anorexia and hyposalivation of ageing is unclear. Thus, the present longitudinal study aimed to investigate the incidence of hyposalivation and its relationship with anorexia in community-dwelling older people in Japan. METHODS: The study population comprised 220 individuals (80 men and 140 women) aged 65-86 years at baseline. The participants underwent comprehensive health check-ups, including dental examinations and anthropometry, and face-to-face interviews in 2013 and 2019. Hyposalivation was determined on the basis of the unstimulated salivary flow rate measured using the modified cotton roll method. Anorexia was defined as a score of ≤29 in the Japanese version of the Council on Nutrition Appetite Questionnaire. Logistic regression analyses were used to test whether the presence of anorexia at baseline was an independent predictor of hyposalivation. RESULTS: Hyposalivation developed at a rate of 19.5% during the 6-year observation period. Anorexia was observed in 95 (43.2%) participants at baseline. After adjusting for potential confounding factors, anorexia (adjusted odds ratio [AOR], 2.65; 95% confidence interval [CI], 1.26-5.57) and polypharmacy (AOR, 3.29; CI, 1.06-10.19) were significant predictors of hyposalivation. CONCLUSION: Loss of appetite is independently correlated with and a risk factor for hyposalivation in older adults. Anorexia of ageing may have negative effects on the salivary flow rate in such settings. Salivation should be a standard feature in clinical assessments of the older adults.
• 地域在住高齢者における歯周疾患リスクとフレイルの関連 2年間の縦断研究
  松原 ちあき; 白部 麻樹; 岩崎 正則; 小原 由紀; 枝広 あや子; 本川 佳子; 稲垣 宏樹; 渡邊 裕; 平野 浩彦; 古屋 純一; 水口 俊介; 新開 省二; 粟田 主一
  日本サルコペニア・フレイル学会雑誌, 4, Suppl., 177, 177, (一社)日本サルコペニア・フレイル学会, Nov. 2020
  Japanese
• A Preliminary Study on the Ability of the Trypsin-Like Peptidase Activity Assay Kit to Detect Periodontitis.
  Masanori Iwasaki; Michihiko Usui; Wataru Ariyoshi; Keisuke Nakashima; Yoshie Nagai-Yoshioka; Maki Inoue; Tatsuji Nishihara
  Dentistry journal, 8, 3, 01 Sep. 2020, [International Magazine]
  English, Scientific journal, This study aimed to explore whether the Trypsin-Like Peptidase Activity Assay Kit (TLP-AA-Kit), which measures the activity of N-benzoyl-dl-arginine peptidase (trypsin-like peptidase), can be used as a reliable tool for periodontitis detection in population-based surveillance. In total, 105 individuals underwent a full-mouth periodontal examination and provided tongue swabs as specimens for further analyses. The results of the TLP-AA-Kit were scored between 1 and 5; higher scores indicated higher trypsin concentrations. Receiver operating characteristic analyses were used to evaluate the predictive validity of the TLP-AA-Kit, where the periodontitis case definition provided by the Centers for Disease Control/American Academy of Periodontology served as the reference. Severe and moderate periodontitis were identified in 4.8% and 16.2% of the study population, respectively. The TLP-AA-Kit showed high diagnostic accuracy for severe periodontitis, with an area under the curve of 0.93 (95% confidence interval = 0.88-0.99). However, the diagnostic accuracy of the TLP-AA-Kit for moderate/severe periodontitis was not reliable. While further studies are necessary to validate our results, the results provided herein highlight the potential of the TLP-AA-Kit as a useful tool for the detection of periodontitis, particularly in severe cases, for population-based surveillance.
• 認知症重症度別の口腔衛生管理に関わる拒否等の症状の実態把握
  白部 麻樹; 枝広 あや子; 小原 由紀; 森下 志穂; 本川 佳子; 本橋 佳子; 五十嵐 憲太郎; 岩崎 正則; 渡邊 裕; 平野 浩彦
  日本歯科衛生学会雑誌, 15, 1, 96, 96, 日本歯科衛生学会, Aug. 2020
  Japanese
• 地域在住高齢者は人工的水分・栄養方法についてのアドバンス・ケア・プランニング(ACP)を望んでいるか?
  和田 泰三; 竜野 真維; 藤澤 道子; 木村 友美; 岩崎 正則; 石本 恭子; 加藤 恵美子; 平山 貴一; 松林 公蔵; 坂本 龍太
  日本老年医学会雑誌, 57, Suppl., 72, 72, (一社)日本老年医学会, Jul. 2020
  Japanese
• 地域在住高齢者の高次ADL低下とフレイルとの関連
  木村 友美; 石本 恭子; 岩崎 正則; 坂本 龍太; 笠原 順子; 藤澤 道子; 加藤 恵美子; 竜野 真維; 和田 泰三; 松林 公蔵
  日本老年医学会雑誌, 57, Suppl., 83, 83, (一社)日本老年医学会, Jul. 2020
  Japanese
• 地域在住後期高齢者における残存歯数と転倒の関連
  渡辺 真光; 濃野 要; 星野 剛志; 田村 浩平; 角田 聡子; 岩崎 正則; 石本 恭子; 木村 友美; 坂本 龍太; 小川 祐司
  日本老年医学会雑誌, 57, Suppl., 134, 134, (一社)日本老年医学会, Jul. 2020
  Japanese
• The relationship between masticatory performance and intakes of foods and nutrients in Japanese male workers: A cross-sectional study.
  Fuyoko Kawashima Bori; Masayo Fukuhara; Chihiro Masaki; Yuko Ohta; Ikuo Nakamichi; Satoko Sakata; Kenichi Goto; Shota Kataoka; Satoko Kakuta; Masanori Iwasaki; Toshihiro Ansai; Ryuji Hosokawa
  Journal of oral rehabilitation, 47, 9, 1142, 1149, 29 Jun. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Although many studies have been conducted on the relationship between masticatory performance and nutrient ingestion in the elderly, few large-scale studies have been carried out using relatively young individuals. OBJECTIVES: The objective of this study was to clarify the association between the masticatory performance evaluated by the gummy-jelly test, not by visual examination, and nutrient ingestion state based on the brief self-administered diet history questionnaire (BDHQ). METHODS: This was a cross-sectional survey of 540 male workers. Somatometry, blood pressure measurement, blood test and medical interview were performed as a periodic health check-up. In the dental check-up, an oral examination, gummy-jelly test (glucosensor) and survey of ingested food and nutrients using BDHQ were performed. The participants were classified into two groups with low and normal values of masticatory performance. Participants with a score on the gummy-jelly test below 150 mg/dL or 150 mg/dL or higher were included in the low and normal groups, respectively. RESULTS: Two hundred and forty-eight participants (45.8%) had low masticatory performance, and 292 (53.2%) had normal masticatory performance. The intakes of some minerals and vitamins, such as calcium, vitamin D, vitamin B2 , small fish with bones and non-oily fish, were significantly lower in the low masticatory group than in the normal group. In contrast, the intake of sugar for coffee and tea and that of chicken were significantly higher in the low masticatory group than in the normal group. CONCLUSION: This study suggested that low masticatory performance can affect nutrient intake, which may cause non-communicable diseases.
• Repositioning of the global epicentre of non-optimal cholesterol.
  NCD Risk Factor Collaboration; NCD-RisC
  Nature, 582, 7810, 73, 77, Jun. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal, High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.
• バス運転手を対象とした咀嚼機能と栄養摂取に関する横断研究
  川島 芙蓉子; 正木 千尋; 福原 正代; 角田 聡子; 片岡 正太; 岩崎 正則; 安細 敏弘; 細川 隆司
  口腔衛生学会雑誌, 70, 2, 106, 107, (一社)日本口腔衛生学会, Apr. 2020
  Japanese
• 高校生におけるインターネット依存度と永久歯う蝕との関連
  佐藤 美寿々; 皆川 久美子; 宮本 茜; 岩崎 正則
  口腔衛生学会雑誌, 70, 増刊, 112, 112, (一社)日本口腔衛生学会, Mar. 2020
  Japanese
• Combined effect of poor appetite and low masticatory function on sarcopenia in community-dwelling Japanese adults aged ≥ 75 years: A 3-year cohort study.
  Soichiro Senoo; Masanori Iwasaki; Yumi Kimura; Satoko Kakuta; Chihiro Masaki; Taizo Wada; Ryota Sakamoto; Yasuko Ishimoto; Michiko Fujisawa; Kiyohito Okumiya; Toshihiro Ansai; Kozo Matsubayashi; Ryuji Hosokawa
  Journal of oral rehabilitation, 47, 5, 643, 650, 19 Feb. 2020, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, OBJECTIVE: This study aimed to investigate the longitudinal association of the combination of poor appetite (PA) and low masticatory function (LMF) with sarcopenia in community-dwelling older adults. METHODS: In total, 173 community-dwelling Japanese adults aged ≥ 75 years participated in the 3-year cohort study. Appetite assessment using the Simplified Nutritional Appetite Questionnaire (SNAQ) and masticatory function assessment using spectrophotometric measurement of differences in gum colour before and after masticating colour-changeable chewing gum (ΔE*ab) were performed at baseline. SNAQ score of ≤ 14 was defined as PA. The lowest tertile of ΔE*ab was defined as LMF. Follow-up examinations were administered annually over a 3-year period to determine sarcopenia incidence, which was defined by the criteria proposed by the Asian Working Group for Sarcopenia. Adjusted hazard ratios (HRs) of sarcopenia incidence according to the presence of PA and LMF were calculated using Cox proportional hazards regression models. RESULTS: At baseline, 81 participants (46.8%) had neither PA nor LMF, 34 (19.7%) had PA alone, 35 (20.2%) had LMF alone, and 23 (13.3%) had both PA and LMF. On follow-up, 31 participants (17.9%) developed sarcopenia. After adjusting for covariates, the adjusted HR for sarcopenia in participants with both PA and LMF was 4.4 (95% confidence interval = 1.6-12.2) compared with those without PA or LMF. PA or LMF alone was not significantly associated with sarcopenia development. CONCLUSIONS: Coexisting PA and LMF increase the risk of sarcopenia development among community-dwelling Japanese adults aged ≥ 75 years.
• National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries
  NCD Risk Factor Collaboration; NCD-RisC
  International Journal of Epidemiology, 49, 1, 173, 192, Oxford University Press (OUP), 01 Feb. 2020, [Peer-reviewed]
  Scientific journal,
  
  
  Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries.
  
  
  
  
  
  We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group.
  
  
  
  
  
  Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China.
  
  
  
  
  
  HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.
  
  
  
• Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants
  Andrea Rodriguez-Martinez; Bin Zhou; Marisa K Sophiea; James Bentham; Christopher J Paciorek; Maria LC Iurilli; Rodrigo M Carrillo-Larco; James E Bennett; Mariachiara Di Cesare; Cristina Taddei; Honor Bixby; Gretchen A Stevens; Leanne M Riley; Melanie J Cowan; Stefan Savin; Goodarz Danaei; Adela Chirita-Emandi; Andre P Kengne; Young-Ho Khang; Avula Laxmaiah; Reza Malekzadeh; J Jaime Miranda; Jin Soo Moon; Stevo R Popovic; Thorkild IA Sørensen; Maroje Soric; Gregor Starc; Ahmad A Zainuddin; Edward W Gregg; Zulfiqar A Bhutta; Robert Black; Leandra Abarca-Gómez; Ziad A Abdeen; Shynar Abdrakhmanova; Suhaila Abdul Ghaffar; Hanan F Abdul Rahim; Niveen M Abu-Rmeileh; Jamila Abubakar Garba; Benjamin Acosta-Cazares; Robert J Adams; Wichai Aekplakorn; Kaosar Afsana; Shoaib Afzal; Imelda A Agdeppa; Javad Aghazadeh-Attari; Carlos A Aguilar-Salinas; Charles Agyemang; Mohamad Hasnan Ahmad; Noor Ani Ahmad; Ali Ahmadi; Naser Ahmadi; Soheir H Ahmed; Wolfgang Ahrens; Gulmira Aitmurzaeva; Kamel Ajlouni; Hazzaa M Al-Hazzaa; Amani Rashed Al-Othman; Rajaa Al-Raddadi; Monira Alarouj; Fadia AlBuhairan; Shahla AlDhukair; Mohamed M Ali; Abdullah Alkandari; Ala'a Alkerwi; Kristine Allin; Mar Alvarez-Pedrerol; Eman Aly; Deepak N Amarapurkar; Parisa Amiri; Norbert Amougou; Philippe Amouyel; Lars Bo Andersen; Sigmund A Anderssen; Lars Ängquist; Ranjit Mohan Anjana; Alireza Ansari-Moghaddam; Hajer Aounallah-Skhiri; Joana Araújo; Inger Ariansen; Tahir Aris; Raphael E Arku; Nimmathota Arlappa; Krishna K Aryal; Thor Aspelund; Felix K Assah; Maria Cecília F Assunção; May Soe Aung; Juha Auvinen; Mária Avdicová; Ana Azevedo; Mohsen Azimi-Nezhad; Fereidoun Azizi; Mehrdad Azmin; Bontha V Babu; Maja Bæksgaard Jørgensen; Azli Baharudin; Suhad Bahijri; Jennifer L Baker; Nagalla Balakrishna; Mohamed Bamoshmoosh; Maciej Banach; Piotr Bandosz; José R Banegas; Joanna Baran; Carlo M Barbagallo; Alberto Barceló; Amina Barkat; Aluisio JD Barros; Mauro Virgílio Gomes Barros; Abdul Basit; Joao Luiz D Bastos; Iqbal Bata; Anwar M Batieha; Rosangela L Batista; Zhamilya Battakova; Assembekov Batyrbek; Louise A Baur; Robert Beaglehole; Silvia Bel-Serrat; Antonisamy Belavendra; Habiba Ben Romdhane; Judith Benedics; Mikhail Benet; James E Bennett; Salim Berkinbayev; Antonio Bernabe-Ortiz; Gailute Bernotiene; Heloísa Bettiol; Jorge Bezerra; Aroor Bhagyalaxmi; Sumit Bharadwaj; Santosh K Bhargava; Zulfiqar A Bhutta; Hongsheng Bi; Yufang Bi; Daniel Bia; Elysée Claude Bika Lele; Mukharram M Bikbov; Bihungum Bista; Dusko J Bjelica; Peter Bjerregaard; Espen Bjertness; Marius B Bjertness; Cecilia Björkelund; Katia V Bloch; Anneke Blokstra; Simona Bo; Martin Bobak; Lynne M Boddy; Bernhard O Boehm; Heiner Boeing; Jose G Boggia; Elena Bogova; Carlos P Boissonnet; Stig E Bojesen; Marialaura Bonaccio; Vanina Bongard; Alice Bonilla-Vargas; Matthias Bopp; Herman Borghs; Pascal Bovet; Lien Braeckevelt; Lutgart Braeckman; Marjolijn CE Bragt; Imperia Brajkovich; Francesco Branca; Juergen Breckenkamp; João Breda; Hermann Brenner; Lizzy M Brewster; Garry R Brian; Lacramioara Brinduse; Sinead Brophy; Graziella Bruno; H Bas Bueno-de-Mesquita; Anna Bugge; Marta Buoncristiano; Genc Burazeri; Con Burns; Antonio Cabrera de León; Joseph Cacciottolo; Hui Cai; Tilema Cama; Christine Cameron; José Camolas; Günay Can; Ana Paula C Cândido; Felicia Cañete; Mario V Capanzana; Nadežda Capková; Eduardo Capuano; Vincenzo Capuano; Marloes Cardol; Viviane C Cardoso; Axel C Carlsson; Esteban Carmuega; Joana Carvalho; José A Casajús; Felipe F Casanueva; Ertugrul Celikcan; Laura Censi; Marvin Cervantes-Loaiza; Juraci A Cesar; Snehalatha Chamukuttan; Angelique W Chan; Queenie Chan; Himanshu K Chaturvedi; Nish Chaturvedi; Norsyamlina Che Abdul Rahim; Chien-Jen Chen; Fangfang Chen; Huashuai Chen; Shuohua Chen; Zhengming Chen; Ching-Yu Cheng; Bahman Cheraghian; Angela Chetrit; Ekaterina Chikova-Iscener; Arnaud Chiolero; Shu-Ti Chiou; Adela Chirita-Emandi; María-Dolores Chirlaque; Belong Cho; Kaare Christensen; Diego G Christofaro; Jerzy Chudek; Renata Cifkova; Michelle Cilia; Eliza Cinteza; Frank Claessens; Janine Clarke; Els Clays; Emmanuel Cohen; Hans Concin; Susana C Confortin; Cyrus Cooper; Tara C Coppinger; Eva Corpeleijn; Simona Costanzo; Dominique Cottel; Chris Cowell; Cora L Craig; Amelia C Crampin; Ana B Crujeiras; Semánová Csilla; Alexandra M Cucu; Liufu Cui; Felipe V Cureau; Graziella D'Arrigo; Eleonora d'Orsi; Liliana Dacica; María Ángeles Dal Re Saavedra; Jean Dallongeville; Albertino Damasceno; Camilla T Damsgaard; Goodarz Danaei; Rachel Dankner; Thomas M Dantoft; Parasmani Dasgupta; Saeed Dastgiri; Luc Dauchet; Kairat Davletov; Guy De Backer; Dirk De Bacquer; Giovanni de Gaetano; Stefaan De Henauw; Paula Duarte de Oliveira; David De Ridder; Karin De Ridder; Susanne R de Rooij; Delphine De Smedt; Mohan Deepa; Alexander D Deev; Vincent Jr DeGennaro; Abbas Dehghan; Hélène Delisle; Francis Delpeuch; Stefaan Demarest; Elaine Dennison; Katarzyna Deren; Valérie Deschamps; Klodian Dhana; Meghnath Dhimal; Augusto F Di Castelnuovo; Juvenal Soares Dias-da-Costa; María Elena Díaz-Sánchez; Alejandro Diaz; Zivka Dika; Shirin Djalalinia; Visnja Djordjic; Ha TP Do; Annette J Dobson; Maria Benedetta Donati; Chiara Donfrancesco; Silvana P Donoso; Angela Döring; Maria Dorobantu; Ahmad Reza Dorosty; Kouamelan Doua; Wojciech Drygas; Jia Li Duan; Charmaine A Duante; Priscilla Duboz; Rosemary B Duda; Vesselka Duleva; Virginija Dulskiene; Samuel C Dumith; Anar Dushpanova; Vilnis Dzerve; Elzbieta Dziankowska-Zaborszczyk; Ricky Eddie; Ebrahim Eftekhar; Eruke E Egbagbe; Robert Eggertsen; Sareh Eghtesad; Gabriele Eiben; Ulf Ekelund; Mohammad El-Khateeb; Jalila El Ati; Denise Eldemire-Shearer; Marie Eliasen; Paul Elliott; Reina Engle-Stone; Macia Enguerran; Rajiv T Erasmus; Raimund Erbel; Cihangir Erem; Louise Eriksen; Johan G Eriksson; Jorge Escobedo-de la Peña; Saeid Eslami; Ali Esmaeili; Alun Evans; David Faeh; Albina A Fakhretdinova; Caroline H Fall; Elnaz Faramarzi; Mojtaba Farjam; Victoria Farrugia Sant'Angelo; Farshad Farzadfar; Mohammad Reza Fattahi; Asher Fawwad; Francisco J Felix-Redondo; Trevor S Ferguson; Romulo A Fernandes; Daniel Fernández-Bergés; Daniel Ferrante; Thomas Ferrao; Marika Ferrari; Marco M Ferrario; Catterina Ferreccio; Eldridge Ferrer; Jean Ferrieres; Thamara Hubler Figueiró; Anna Fijalkowska; Günther Fink; Krista Fischer; Bernhard Föger; Leng Huat Foo; Maria Forsner; Heba M Fouad; Damian K Francis; Maria do Carmo Franco; Oscar H Franco; Ruth Frikke-Schmidt; Guillermo Frontera; Flavio D Fuchs; Sandra C Fuchs; Isti I Fujiati; Yuki Fujita; Matsuda Fumihiko; Takuro Furusawa; Zbigniew Gaciong; Mihai Gafencu; Andrzej Galbarczyk; Henrike Galenkamp; Daniela Galeone; Myriam Galfo; Fabio Galvano; Jingli Gao; Manoli Garcia-de-la-Hera; Marta García-Solano; Dickman Gareta; Sarah P Garnett; Jean-Michel Gaspoz; Magda Gasull; Adroaldo Cesar Araujo Gaya; Anelise Reis Gaya; Andrea Gazzinelli; Ulrike Gehring; Harald Geiger; Johanna M Geleijnse; Ali Ghanbari; Erfan Ghasemi; Oana-Florentina Gheorghe-Fronea; Simona Giampaoli; Francesco Gianfagna; Tiffany K Gill; Jonathan Giovannelli; Glen Gironella; Aleksander Giwercman; Konstantinos Gkiouras; Justyna Godos; Sibel Gogen; Rebecca A Goldsmith; David Goltzman; Santiago F Gómez; Aleksandra Gomula; Bruna Goncalves Cordeiro da Silva; Helen Gonçalves; David A Gonzalez-Chica; Marcela Gonzalez-Gross; Margot González-Leon; Juan P González-Rivas; Clicerio González-Villalpando; María-Elena González-Villalpando; Angel R Gonzalez; Frederic Gottrand; Antonio Pedro Graça; Sidsel Graff-Iversen; Dušan Grafnetter; Aneta Grajda; Maria G Grammatikopoulou; Ronald D Gregor; Tomasz Grodzicki; Else Karin Grøholt; Anders Grøntved; Giuseppe Grosso; Gabriella Gruden; Dongfeng Gu; Emanuela Gualdi-Russo; Pilar Guallar-Castillón; Andrea Gualtieri; Elias F Gudmundsson; Vilmundur Gudnason; Ramiro Guerrero; Idris Guessous; Andre L Guimaraes; Martin C Gulliford; Johanna Gunnlaugsdottir; Marc J Gunter; Xiu-Hua Guo; Yin Guo; Prakash C Gupta; Rajeev Gupta; Oye Gureje; Beata Gurzkowska; Enrique Gutiérrez-González; Laura Gutierrez; Felix Gutzwiller; Seongjun Ha; Farzad Hadaegh; Charalambos A Hadjigeorgiou; Rosa Haghshenas; Hamid Hakimi; Jytte Halkjær; Ian R Hambleton; Behrooz Hamzeh; Dominique Hange; Abu AM Hanif; Sari Hantunen; Rachakulla Hari Kumar; Seyed Mohammad Hashemi-Shahri; Maria Hassapidou; Jun Hata; Teresa Haugsgjerd; Alison J Hayes; Jiang He; Yuan He; Yuna He; Regina Heidinger-Felso; Mirjam Heinen; Tatjana Hejgaard; Marleen Elisabeth Hendriks; Rafael dos Santos Henrique; Ana Henriques; Leticia Hernandez Cadena; Sauli Herrala; Victor M Herrera; Isabelle Herter-Aeberli; Ramin Heshmat; Allan G Hill; Sai Yin Ho; Suzanne C Ho; Michael Hobbs; Albert Hofman; Ingunn Holden Bergh; Michelle Holdsworth; Reza Homayounfar; Clara Homs; Wilma M Hopman; Andrea RVR Horimoto; Claudia M Hormiga; Bernardo L Horta; Leila Houti; Christina Howitt; Thein Thein Htay; Aung Soe Htet; Maung Maung Than Htike; Yonghua Hu; José María Huerta; Ilpo Tapani Huhtaniemi; Constanta Huidumac Petrescu; Abdullatif Husseini; Chinh Nguyen Huu; Inge Huybrechts; Nahla Hwalla; Jolanda Hyska; Licia Iacoviello; Jesús M Ibarluzea; Mohsen M Ibrahim; Norazizah Ibrahim Wong; Nayu Ikeda; M Arfan Ikram; Violeta Iotova; Vilma E Irazola; Takafumi Ishida; Muhammad Islam; Sheikh Mohammed Shariful Islam; Masanori Iwasaki; Rod T Jackson; Jeremy M Jacobs; Hashem Y Jaddou; Tazeen Jafar; Kenneth James; Kazi M Jamil; Konrad Jamrozik; Imre Janszky; Edward Janus; Juel Jarani; Marjo-Riitta Jarvelin; Grazyna Jasienska; Ana Jelakovic; Bojan Jelakovic; Garry Jennings; Anjani Kumar Jha; Chao Qiang Jiang; Ramon O Jimenez; Karl-Heinz Jöckel; Michel Joffres; Mattias Johansson; Jari J Jokelainen; Jost B Jonas; Torben Jørgensen; Pradeep Joshi; Farahnaz Joukar; Dragana P Jovic; Jacek J Józwiak; Anne Juolevi; Gregor Jurak; Iulia Jurca Simina; Vesna Juresa; Rudolf Kaaks; Felix O Kaducu; Anthony Kafatos; Eero O Kajantie; Zhanna Kalmatayeva; Ofra Kalter-Leibovici; Yves Kameli; Kodanda R Kanala; Srinivasan Kannan; Efthymios Kapantais; Khem B Karki; Marzieh Katibeh; Joanne Katz; Peter T Katzmarzyk; Jussi Kauhanen; Prabhdeep Kaur; Maryam Kavousi; Gyulli M Kazakbaeva; Ulrich Keil; Lital Keinan Boker; Sirkka Keinänen-Kiukaanniemi; Roya Kelishadi; Cecily Kelleher; Han CG Kemper; Andre P Kengne; Maryam Keramati; Alina Kerimkulova; Mathilde Kersting; Timothy Key; Yousef Saleh Khader; Davood Khalili; Young-Ho Khang; Kay-Tee Khaw; Bahareh Kheiri; Motahareh Kheradmand; Alireza Khosravi; Ilse MSL Khouw; Ursula Kiechl-Kohlendorfer; Stefan Kiechl; Japhet Killewo; Dong Wook Kim; Hyeon Chang Kim; Jeongseon Kim; Jenny M Kindblom; Heidi Klakk; Magdalena Klimek; Jeannette Klimont; Jurate Klumbiene; Michael Knoflach; Bhawesh Koirala; Elin Kolle; Patrick Kolsteren; Jürgen König; Raija Korpelainen; Paul Korrovits; Magdalena Korzycka; Jelena Kos; Seppo Koskinen; Katsuyasu Kouda; Viktoria A Kovacs; Sudhir Kowlessur; Slawomir Koziel; Wolfgang Kratzer; Susi Kriemler; Peter Lund Kristensen; Steiner Krokstad; Daan Kromhout; Branimir Krtalic; Herculina S Kruger; Ruzena Kubinova; Renata Kuciene; Urho M Kujala; Enisa Kujundzic; Zbigniew Kulaga; R Krishna Kumar; Marie Kunešová; Pawel Kurjata; Yadlapalli S Kusuma; Kari Kuulasmaa; Catherine Kyobutungi; Quang Ngoc La; Fatima Zahra Laamiri; Tiina Laatikainen; Carl Lachat; Youcef Laid; Tai Hing Lam; Christina-Paulina Lambrinou; Edwige Landais; Vera Lanska; Georg Lappas; Bagher Larijani; Tint Swe Latt; Laura Lauria; Avula Laxmaiah; Maria Lazo-Porras; Khanh Le Nguyen Bao; Agnès Le Port; Tuyen D Le; Jeannette Lee; Jeonghee Lee; Paul H Lee; Nils Lehmann; Terho Lehtimäki; Daniel Lemogoum; Naomi S Levitt; Yanping Li; Merike Liivak; Christa L Lilly; Wei-Yen Lim; M Fernanda Lima-Costa; Hsien-Ho Lin; Xu Lin; Yi-Ting Lin; Lars Lind; Allan Linneberg; Lauren Lissner; Mieczyslaw Litwin; Jing Liu; Lijuan Liu; Wei-Cheng Lo; Helle-Mai Loit; Khuong Quynh Long; Luis Lopes; Oscar Lopes; Esther Lopez-Garcia; Tania Lopez; Paulo A Lotufo; José Eugenio Lozano; Janice L Lukrafka; Dalia Luksiene; Annamari Lundqvist; Robert Lundqvist; Nuno Lunet; Charles Lunogelo; Michala Lustigová; Edyta Luszczki; Guansheng Ma; Jun Ma; Xu Ma; George LL Machado-Coelho; Aristides M Machado-Rodrigues; Suka Machi; Luisa M Macieira; Ahmed A Madar; Stefania Maggi; Dianna J Magliano; Sara Magnacca; Emmanuella Magriplis; Gowri Mahasampath; Bernard Maire; Marjeta Majer; Marcia Makdisse; Päivi Mäki; Fatemeh Malekzadeh; Reza Malekzadeh; Rahul Malhotra; Kodavanti Mallikharjuna Rao; Sofia K Malyutina; Lynell V Maniego; Yannis Manios; Jim I Mann; Fariborz Mansour-Ghanaei; Enzo Manzato; Paula Margozzini; Anastasia Markaki; Oonagh Markey; Eliza Markidou Ioannidou; Pedro Marques-Vidal; Larissa Pruner Marques; Jaume Marrugat; Yves Martin-Prevel; Rosemarie Martin; Reynaldo Martorell; Eva Martos; Stefano Marventano; Luis P Mascarenhas; Shariq R Masoodi; Ellisiv B Mathiesen; Prashant Mathur; Alicia Matijasevich; Tandi E Matsha; Christina Mavrogianni; Artur Mazur; Jean Claude N Mbanya; Shelly R McFarlane; Stephen T McGarvey; Martin McKee; Stela McLachlan; Rachael M McLean; Scott B McLean; Breige A McNulty; Sounnia Mediene-Benchekor; Jurate Medzioniene; Parinaz Mehdipour; Kirsten Mehlig; Amir Houshang Mehrparvar; Aline Meirhaeghe; Jørgen Meisfjord; Christa Meisinger; Ana Maria B Menezes; Geetha R Menon; Gert BM Mensink; Maria Teresa Menzano; Alibek Mereke; Indrapal I Meshram; Andres Metspalu; Jie Mi; Kim F Michaelsen; Nathalie Michels; Kairit Mikkel; Karolina Milkowska; Jody C Miller; Cláudia S Minderico; GK Mini; Juan Francisco Miquel; J Jaime Miranda; Mohammad Reza Mirjalili; Daphne Mirkopoulou; Erkin Mirrakhimov; Marjeta Mišigoj-Durakovic; Antonio Mistretta; Veronica Mocanu; Pietro A Modesti; Sahar Saeedi Moghaddam; Bahram Mohajer; Mostafa K Mohamed; Shukri F Mohamed; Kazem Mohammad; Zahra Mohammadi; Noushin Mohammadifard; Reza Mohammadpourhodki; Viswanathan Mohan; Salim Mohanna; Muhammad Fadhli Mohd Yusoff; Iraj Mohebbi; Farnam Mohebi; Marie Moitry; Drude Molbo; Line T Møllehave; Niels C Møller; Dénes Molnár; Amirabbas Momenan; Charles K Mondo; Michele Monroy-Valle; Eric Monterrubio-Flores; Kotsedi Daniel K Monyeki; Jin Soo Moon; Mahmood Moosazadeh; Leila B Moreira; Alain Morejon; Luis A Moreno; Karen Morgan; Suzanne N Morin; Erik Lykke Mortensen; George Moschonis; Malgorzata Mossakowska; Aya Mostafa; Anabela Mota-Pinto; Jorge Mota; Mohammad Esmaeel Motlagh; Jorge Motta; Marcos André Moura-dos-Santos; Malay K Mridha; Kelias P Msyamboza; Thet Thet Mu; Magdalena Muc; Boban Mugoša; Maria L Muiesan; Parvina Mukhtorova; Martina Müller-Nurasyid; Neil Murphy; Jaakko Mursu; Elaine M Murtagh; Kamarul Imran Musa; Sanja Music Milanovic; Vera Musil; Norlaila Mustafa; Iraj Nabipour; Shohreh Naderimagham; Gabriele Nagel; Balkish M Naidu; Farid Najafi; Harunobu Nakamura; Jana Námešná; Ei Ei K Nang; Vinay B Nangia; Martin Nankap; Sameer Narake; Paola Nardone; Matthias Nauck; William A Neal; Azim Nejatizadeh; Keiu Nelis; Liis Nelis; Ilona Nenko; Martin Neovius; Flavio Nervi; Chung T Nguyen; D Nguyen; Quang Ngoc Nguyen; Ramfis E Nieto-Martínez; Yury P Nikitin; Guang Ning; Toshiharu Ninomiya; Sania Nishtar; Marianna Noale; Oscar A Noboa; Helena Nogueira; Teresa Norat; Maria Nordendahl; Børge G Nordestgaard; Davide Noto; Natalia Nowak-Szczepanska; Mohannad Al Nsour; Irfan Nuhoglu; Eha Nurk; Terence W O'Neill; Dermot O'Reilly; Galina Obreja; Caleb Ochimana; Angélica M Ochoa-Avilés; Eiji Oda; Kyungwon Oh; Kumiko Ohara; Claes Ohlsson; Ryutaro Ohtsuka; Örn Olafsson; Maria Teresa A Olinto; Isabel O Oliveira; Mohd Azahadi Omar; Altan Onat; Sok King Ong; Lariane M Ono; Pedro Ordunez; Rui Ornelas; Ana P Ortiz; Pedro J Ortiz; Merete Osler; Clive Osmond; Sergej M Ostojic; Afshin Ostovar; Johanna A Otero; Kim Overvad; Ellis Owusu-Dabo; Fred Michel Paccaud; Cristina Padez; Ioannis Pagkalos; Elena Pahomova; Karina Mary de Paiva; Andrzej Pajak; Domenico Palli; Alberto Palloni; Luigi Palmieri; Wen-Harn Pan; Songhomitra Panda-Jonas; Arvind Pandey; Francesco Panza; Dimitrios Papandreou; Soon-Woo Park; Suyeon Park; Winsome R Parnell; Mahboubeh Parsaeian; Ionela M Pascanu; Patrick Pasquet; Nikhil D Patel; Mangesh S Pednekar; Nasheeta Peer; Sergio Viana Peixoto; Markku Peltonen; Alexandre C Pereira; Marco A Peres; Napoleón Pérez-Farinós; Cynthia M Pérez; Valentina Peterkova; Annette Peters; Astrid Petersmann; Janina Petkeviciene; Ausra Petrauskiene; Emanuela Pettenuzzo; Niloofar Peykari; Son Thai Pham; Rafael N Pichardo; Daniela Pierannunzio; Iris Pigeot; Hynek Pikhart; Aida Pilav; Lorenza Pilotto; Francesco Pistelli; Freda Pitakaka; Aleksandra Piwonska; Andreia N Pizarro; Pedro Plans-Rubió; Bee Koon Poh; Hermann Pohlabeln; Raluca M Pop; Stevo R Popovic; Miquel Porta; Georg Posch; Anil Poudyal; Dimitrios Poulimeneas; Hamed Pouraram; Farhad Pourfarzi; Akram Pourshams; Hossein Poustchi; Rajendra Pradeepa; Alison J Price; Jacqueline F Price; Rui Providencia; Jardena J Puder; Iveta Pudule; Soile E Puhakka; Maria Puiu; Margus Punab; Radwan F Qasrawi; Mostafa Qorbani; Tran Quoc Bao; Ivana Radic; Ricardas Radisauskas; Salar Rahimikazerooni; Mahfuzar Rahman; Mahmudur Rahman; Olli Raitakari; Manu Raj; Ellina Rakhimova; Sherali Rakhmatulloev; Ivo Rakovac; Sudha Ramachandra Rao; Ambady Ramachandran; Jacqueline Ramke; Elisabete Ramos; Rafel Ramos; Lekhraj Rampal; Sanjay Rampal; Vayia Rarra; Ramon A Rascon-Pacheco; Mette Rasmussen; Cassiano Ricardo Rech; Josep Redon; Paul Ferdinand M Reganit; Valéria Regecová; Luis Revilla; Abbas Rezaianzadeh; Lourdes Ribas-Barba; Robespierre Ribeiro; Elio Riboli; Adrian Richter; Fernando Rigo; Natascia Rinaldo; Tobias F Rinke de Wit; Ana Rito; Raphael M Ritti-Dias; Juan A Rivera; Cynthia Robitaille; Romana Roccaldo; Daniela Rodrigues; Fernando Rodríguez-Artalejo; María del Cristo Rodriguez-Perez; Laura A Rodríguez-Villamizar; Ulla Roggenbuck; Rosalba Rojas-Martinez; Nipa Rojroongwasinkul; Dora Romaguera; Elisabetta L Romeo; Rafaela V Rosario; Annika Rosengren; Ian Rouse; Joel GR Roy; Adolfo Rubinstein; Frank J Rühli; Jean-Bernard Ruidavets; Blanca Sandra Ruiz-Betancourt; Emma Ruiz Moreno; Iuliia A Rusakova; Kenisha Russell Jonsson; Paola Russo; Petra Rust; Marcin Rutkowski; Charumathi Sabanayagam; Elena Sacchini; Harshpal S Sachdev; Alireza Sadjadi; Ali Reza Safarpour; Sare Safi; Saeid Safiri; Olfa Saidi; Nader Saki; Benoit Salanave; Eduardo Salazar Martinez; Diego Salmerón; Veikko Salomaa; Jukka T Salonen; Massimo Salvetti; Margarita Samoutian; Jose Sánchez-Abanto; Sandjaja; Susana Sans; Loreto Santa Marina; Diana A Santos; Ina S Santos; Lèlita C Santos; Maria Paula Santos; Osvaldo Santos; Rute Santos; Sara Santos Sanz; Jouko L Saramies; Luis B Sardinha; Nizal Sarrafzadegan; Thirunavukkarasu Sathish; Kai-Uwe Saum; Savvas Savva; Mathilde Savy; Norie Sawada; Mariana Sbaraini; Marcia Scazufca; Beatriz D Schaan; Angelika Schaffrath Rosario; Herman Schargrodsky; Anja Schienkiewitz; Karin Schindler; Sabine Schipf; Carsten O Schmidt; Ida Maria Schmidt; Peter Schnohr; Ben Schöttker; Sara Schramm; Stine Schramm; Helmut Schröder; Constance Schultsz; Aletta E Schutte; Sylvain Sebert; Aye Aye Sein; Rusidah Selamat; Vedrana Sember; Abhijit Sen; Idowu O Senbanjo; Sadaf G Sepanlou; Victor Sequera; Luis Serra-Majem; Jennifer Servais; Ludmila Ševcíková; Svetlana A Shalnova; Teresa Shamah-Levy; Morteza Shamshirgaran; Coimbatore Subramaniam Shanthirani; Maryam Sharafkhah; Sanjib K Sharma; Jonathan E Shaw; Amaneh Shayanrad; Ali Akbar Shayesteh; Lela Shengelia; Zumin Shi; Kenji Shibuya; Hana Shimizu-Furusawa; Dong Wook Shin; Youchan Shin; Majid Shirani; Rahman Shiri; Namuna Shrestha; Khairil Si-Ramlee; Alfonso Siani; Rosalynn Siantar; Abla M Sibai; Antonio M Silva; Diego Augusto Santos Silva; Mary Simon; Judith Simons; Leon A Simons; Agneta Sjöberg; Michael Sjöström; Gry Skodje; Jolanta Slowikowska-Hilczer; Przemyslaw Slusarczyk; Liam Smeeth; Hung-Kwan So; Fernanda Cunha Soares; Grzegorz Sobek; Eugène Sobngwi; Morten Sodemann; Stefan Söderberg; Moesijanti YE Soekatri; Agustinus Soemantri; Reecha Sofat; Vincenzo Solfrizzi; Mohammad Hossein Somi; Emily Sonestedt; Yi Song; Thorkild IA Sørensen; Elin P Sørgjerd; Maroje Soric; Charles Sossa Jérome; Victoria E Soto-Rojas; Aïcha Soumaré; Slavica Sovic; Bente Sparboe-Nilsen; Karen Sparrenberger; Angela Spinelli; Igor Spiroski; Jan A Staessen; Hanspeter Stamm; Gregor Starc; Maria G Stathopoulou; Kaspar Staub; Bill Stavreski; Jostein Steene-Johannessen; Peter Stehle; Aryeh D Stein; George S Stergiou; Jochanan Stessman; Ranko Stevanovic; Jutta Stieber; Doris Stöckl; Tanja Stocks; Jakub Stokwiszewski; Ekaterina Stoyanova; Gareth Stratton; Karien Stronks; Maria Wany Strufaldi; Lela Sturua; Ramón Suárez-Medina; Machi Suka; Chien-An Sun; Johan Sundström; Yn-Tz Sung; Jordi Sunyer; Paibul Suriyawongpaisal; Boyd A Swinburn; Rody G Sy; Holly E Syddall; René Charles Sylva; Moyses Szklo; Lucjan Szponar; E Shyong Tai; Mari-Liis Tammesoo; Abdonas Tamosiunas; Eng Joo Tan; Xun Tang; Frank Tanser; Yong Tao; Mohammed Rasoul Tarawneh; Jakob Tarp; Carolina B Tarqui-Mamani; Radka Taxová Braunerová; Anne Taylor; Julie Taylor; Félicité Tchibindat; William R Tebar; Grethe S Tell; Tania Tello; KR Thankappan; Holger Theobald; Xenophon Theodoridis; Lutgarde Thijs; Nihal Thomas; Betina H Thuesen; Lubica Tichá; Erik J Timmermans; Anne Tjonneland; Hanna K Tolonen; Janne S Tolstrup; Murat Topbas; Roman Topór-Madry; Liv Elin Torheim; María José Tormo; Michael J Tornaritis; Maties Torrent; Laura Torres-Collado; Stefania Toselli; Pierre Traissac; Thi Tuyet-Hanh Tran; Dimitrios Trichopoulos; Antonia Trichopoulou; Oanh TH Trinh; Atul Trivedi; Lechaba Tshepo; Maria Tsigga; Shoichiro Tsugane; Azaliia M Tuliakova; Marshall K Tulloch-Reid; Fikru Tullu; Tomi-Pekka Tuomainen; Jaakko Tuomilehto; Maria L Turley; Per Tynelius; Themistoklis Tzotzas; Christophe Tzourio; Peter Ueda; Eunice Ugel; Flora AM Ukoli; Hanno Ulmer; Belgin Unal; Zhamyila Usupova; Hannu MT Uusitalo; Nalan Uysal; Justina Vaitkeviciute; Gonzalo Valdivia; Susana Vale; Damaskini Valvi; Rob M van Dam; Johan Van der Heyden; Yvonne T van der Schouw; Koen Van Herck; Hoang Van Minh; Irene GM van Valkengoed; Dirk Vanderschueren; Diego Vanuzzo; Anette Varbo; Gregorio Varela-Moreiras; Patricia Varona-Pérez; Senthil K Vasan; Tomas Vega; Toomas Veidebaum; Gustavo Velasquez-Melendez; Biruta Velika; Giovanni Veronesi; WM Monique Verschuren; Cesar G Victora; Giovanni Viegi; Lucie Viet; Salvador Villalpando; Paolo Vineis; Jesus Vioque; Jyrki K Virtanen; Marjolein Visser; Sophie Visvikis-Siest; Bharathi Viswanathan; Mihaela Vladulescu; Tiina Vlasoff; Dorja Vocanec; Henry Völzke; Ari Voutilainen; Sari Voutilainen; Martine Vrijheid; Tanja GM Vrijkotte; Alisha N Wade; Aline Wagner; Thomas Waldhör; Janette Walton; Elvis OA Wambiya; Wan Mohamad Wan Bebakar; Wan Nazaimoon Wan Mohamud; Rildo de Souza Wanderley Júnior; Ming-Dong Wang; Ningli Wang; Qian Wang; Xiangjun Wang; Ya Xing Wang; Ying-Wei Wang; S Goya Wannamethee; Nicholas Wareham; Adelheid Weber; Niels Wedderkopp; Deepa Weerasekera; Daniel Weghuber; Wenbin Wei; Aneta Weres; Bo Werner; Peter H Whincup; Kurt Widhalm; Indah S Widyahening; Andrzej Wiecek; Rainford J Wilks; Johann Willeit; Peter Willeit; Julianne Williams; Tom Wilsgaard; Bogdan Wojtyniak; Roy A Wong-McClure; Andrew Wong; Jyh Eiin Wong; Tien Yin Wong; Jean Woo; Mark Woodward; Frederick C Wu; Jianfeng Wu; Li Juan Wu; Shouling Wu; Haiquan Xu; Liang Xu; Nor Azwany Yaacob; Uruwan Yamborisut; Weili Yan; Ling Yang; Xiaoguang Yang; Yang Yang; Nazan Yardim; Mehdi Yaseri; Tabara Yasuharu; Xingwang Ye; Panayiotis K Yiallouros; Moein Yoosefi; Akihiro Yoshihara; Qi Sheng You; San-Lin You; Novie O Younger-Coleman; Safiah Md Yusof; Ahmad Faudzi Yusoff; Luciana Zaccagni; Vassilis Zafiropulos; Ahmad A Zainuddin; Seyed Rasoul Zakavi; Farhad Zamani; Sabina Zambon; Antonis Zampelas; Hana Zamrazilová; Maria Elisa Zapata; Abdul Hamid Zargar; Ko Ko Zaw; Tomasz Zdrojewski; Tajana Zeljkovic Vrkic; Yi Zeng; Luxia Zhang; Zhen-Yu Zhang; Dong Zhao; Ming-Hui Zhao; Wenhua Zhao; Shiqi Zhen; Wei Zheng; Yingfeng Zheng; Bekbolat Zholdin; Maigeng Zhou; Dan Zhu; Yanina Zocalo; Julio Zuñiga Cisneros; Monika Zuziak; Majid Ezzati
  The Lancet, 396, 10261, 1511, 1524, Elsevier BV, 2020, [Peer-reviewed]
  Scientific journal
• 学童期における唾液中乳酸脱水素酵素とストレスの関連について
  田村 浩平; 葭原 明弘; 諏訪間 加奈; 角田 聡子; 岩崎 正則; 安細 敏弘; 小川 祐司
  口腔衛生学会雑誌, 70, 1, 47, 48, (一社)日本口腔衛生学会, Jan. 2020, [Peer-reviewed]
  Japanese
• Associations between periodontal health/treatment and cognitive impairment: Latest evidence from epidemiological studies
  Misuzu Sato; Masanori Iwasaki; Kumiko Minagawa; Akane Miyamoto
  Current Oral Health Reports, 2020, [Peer-reviewed], [Invited], [Corresponding author]
• 日本とドイツにおける口腔健康とその費用効率性に関する比較(A Comparison of Oral Health in Japan and Germany and Its Cost Efficiency)
  Kocher Thomas; Iwasaki Masanori; Yoshihara Akihiro; Hoshino Takashi
  老年歯科医学, 34, 3, 342, 353, (一社)日本老年歯科医学会, Dec. 2019
  English, 日本とドイツには共に診療報酬制の法定健康保険制度があり、しかも口腔健康に関する代表的な調査研究が存在している。ドイツの代表的研究であるDeutsche Mundgesundheitsstudie(DMS III、DMS IV、DMS V研究)と日本の厚生労働省による歯科疾患実態調査のデータを利用し、両国の一般集団にみられる口腔健康と歯科健康保険制度のパフォーマンスを比較した。1997年におけるドイツ人の成人集団(35〜44歳)の平均歯数は25.3本、2014年では27.2本であった。日本の1999年の成人集団では27.2本、2016年では28.3本であった。高齢集団(65〜74歳)に関しては、上記と同じ2時点においてドイツ人の場合には平均歯数は10.1本と15.5本、日本人の場合には14.7本と22.7本であり、両国において歯数は増加していた。上記のように両国間の比較では成人集団、高齢集団のいずれの場合でも日本人の残存歯数の方が多かった。ドイツ人1人当たりの歯科診療医療費は上記と同じ2時点において216ユーロと302ユーロ、日本人では178ユーロと195ユーロであった。残存歯数の観点から総合的に判断するとドイツよりも日本の方が歯科医療費資源を効率的に利用していると考えられた。
• A Comparison of Oral Health in Japan and Germany and Its Cost Efficiency
  Kocher Thomas; Iwasaki Masanori; Yoshihara Akihiro; Hoshino Takashi
  老年歯科医学, 34, 3, 342, 353, (一社)日本老年歯科医学会, Dec. 2019, [Peer-reviewed]
  English
• Association between anorexia and poor chewing ability among community-dwelling older adults in Japan.
  Yumi Kimura; Masanori Iwasaki; Yasuko Ishimoto; Kwanchit Sasiwongsaroj; Ryota Sakamoto; Taizo Wada; Michiko Fujisawa; Kiyohito Okumiya; Hideo Miyazaki; Kozo Matsubayashi
  Geriatrics & gerontology international, 19, 12, 1290, 1292, Dec. 2019, [Peer-reviewed], [Domestic magazines]
  English
• Predicting gingivitis using visual gingival redness examination on 11 years old Japanese schoolchildren: A ROC analysis
  Lisdrianto Hanindriyo; Akihiro Yoshihara; Hiro-O Ito; Kana Suwama; Satoko Kakuta; Makoto Fukui; Masanori Iwasaki; Naofumi Tamaki; Toshihiro Ansai
  PEDIATRIC DENTAL JOURNAL, 29, 2, 66, 71, Aug. 2019, [Peer-reviewed]
  English, Scientific journal
• 加齢に伴う歯数の変化の軌跡と生命予後の関連 高齢期に28歯を維持することの意義
  岩崎 正則; 佐藤 美寿々; 皆川 久美子; 安細 敏弘; 小川 祐司; 葭原 明弘
  口腔衛生学会雑誌, 69, 3, 131, 138, (一社)日本口腔衛生学会, Jul. 2019, [Peer-reviewed], [Lead author, Corresponding author]
  Japanese
• A polymorphism rs6815464 in the macrophage erythroblast attacher gene is associated with low bone mineral density in postmenopausal Japanese women.
  Yulan Che; Noriko Sugita; Akihiro Yoshihara; Masanori Iwasaki; Hideo Miyazaki; Kazutoshi Nakamura; Hiromasa Yoshie
  Gene, 700, 1, 6, 05 Jun. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND AND PURPOSES: Osteoporosis and osteopenia are multifactorial diseases characterized by low bone mineral density (BMD) and are susceptible to genetic and environmental risk factors. The macrophage erythroblast attacher (MAEA) was discovered as a protein to mediate the attachment of erythroid cells to macrophages and is essential for bone marrow hematopoiesis. MAEA is expressed in a wide range of cells and tissues including osteoblasts and osteoclasts. Recent studies have shown that a single nucleotide polymorphism (SNP) rs6815464 (C/G) in the MAEA gene increases the susceptibility of type 2 diabetes mellitus. However, the contribution of MAEA to bone metabolism remains unknown. Therefore, we performed this study to evaluate the association between MAEA polymorphism and low BMD. METHODS: In a cross-sectional study with postmenopausal Japanese women living in the Yokogoshi area, Niigata City, we evaluated whether rs6815464 was associated with low BMD. Blood samples were collected from 353 subjects (age 63.8 ± 5.4 years). The MAEA genotype was determined by TaqMan assay. BMD was assessed by dual-energy X-ray absorptiometry at the lumbar spine (L2-L4), hip and femoral neck. Low BMD was defined as a T-score <-1. RESULTS: The percentage of subjects with low BMD in the lumbar spine, total hip and femoral neck were 71%, 75% and 84% respectively. After adjusting age, BMI, HbA1c, smoking and alcohol consumption, the G-allele carriage was found to be associated with low BMD of total hip (odds ratio = 2.11, 95% CI: 1.14-3.91, P = 0.018), but not of the lumbar spine or femoral neck. CONCLUSION: The MAEA gene polymorphism rs6815464 was associated with low hip BMD in postmenopausal Japanese women.
• Interaction between beta-3 adrenergic receptor genotype and environmental factors on periodontal progression.
  Akihiro Yoshihara; Noboru Kaneko; Kaname Nohno; Masanori Iwasaki
  Journal of clinical periodontology, 46, 6, 623, 630, Jun. 2019, [Peer-reviewed], [International Magazine]
  English, OBJECTIVES: The purpose of this longitudinal study was to evaluate the relationship between beta-3 adrenergic receptor polymorphism and environmental factors such as smoking on periodontal disease by considering effect modification. MATERIALS AND METHODS: A total of 294 subjects who participated in all follow-up surveys over the 6-year study period were analysed. After dividing subjects into tertiles according to the number of years exposed to smoking, we conducted Poisson regression analysis to compare the incidence rate ratio (IRR) for periodontal disease events during the 6-year study period with beta-3 adrenergic receptor genotype (1: Arg allele carriers, 2: Arg allele non-carriers) for each tertile adjusted for other four variables. RESULTS: The number of years exposed to smoking (mean ± standard deviation) for the 1st, 2nd and 3rd tertiles was 0 ± 0, 20.1 ± 9.1 and 45.3 ± 7.7 years, respectively. The IRRs ± SE were 0.89 ± 0.08 (p = 0.218) for the 1st tertile, 1.93 ± 0.36 (p < 0.001) for the 2nd tertile and 2.56 ± 0.23 (p < 0.001) for the 3rd tertile. CONCLUSION: There was a clear dose-response relationship between beta-3 adrenergic receptor genotype and periodontal disease progression based on the number of years exposed to smoking.
• MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females: A cross-sectional study.
  Yulan Che; Noriko Sugita; Akihiro Yoshihara; Masanori Iwasaki; Hideo Miyazaki; Kazutoshi Nakamura; Hiromasa Yoshie
  Archives of oral biology, 102, 128, 134, Jun. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal, OBJECTIVES: Macrophage erythroblast attacher (MAEA) is a membrane protein that regulates the development of mature macrophages by mediating attachment with erythroblasts. A polymorphism rs6815464 (C/G) in MAEA gene was reported to be associated with type II diabetes. Along with diabetes, osteoporosis shows an increased prevalence in postmenopausal females, and both diseases have been reported to be associated with periodontitis. Therefore, we explored the relevance of the MAEA polymorphism to periodontitis, bone mineral density (BMD) and haemoglobin A1c (HbA1c). DESIGN: This was a cross-sectional study with the final sample comprised of 344 postmenopausal Japanese females. Probing pocket depth (PPD) and clinical attachment level (CAL) were measured. Genotype was determined by TaqMan assay. Blood biochemical parameters and BMD of the lumbar spine were evaluated. RESULTS: No differences were found in age, body mass index, HbA1c, BMD, number of teeth, bone metabolism parameters between the genotypes. Mean CAL and percentage of sites with PPD or CAL ≥ 5 mm were higher in the G-allele carriers than in the non-carriers. Multiple logistic regression analyses revealed that G-allele carriage was associated with severe periodontitis (odds ratio = 3.73, 95% CI = 1.36-10.19). CONCLUSION: Our results suggested that the MAEA gene polymorphism was independently associated with severe periodontitis.
• Periodontitis, periodontal inflammation, and mild cognitive impairment: A 5-year cohort study.
  Masanori Iwasaki; Yumi Kimura; Hiroshi Ogawa; Takayuki Yamaga; Toshihiro Ansai; Taizo Wada; Ryota Sakamoto; Yasuko Ishimoto; Michiko Fujisawa; Kiyohito Okumiya; Hideo Miyazaki; Kozo Matsubayashi
  Journal of periodontal research, 54, 3, 233, 240, Jun. 2019, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, BACKGROUND AND OBJECTIVES: Identification of modifiable factors for mild cognitive impairment (MCI) is important since individuals with MCI are at a high risk of dementia and disability. Previous studies have suggested a potential association between periodontitis and cognitive impairment, but the results remain inconclusive. We designed a 5-year longitudinal study to explore the association between MCI and periodontitis and periodontal inflammation in older adults. METHODS: This study included 179 community-dwelling dentate individuals (62 men and 117 women, average age: 80.1 years). A full-mouth periodontal examination at six sites per tooth was performed at baseline. Case definitions provided by the European Workshop in Periodontology Group C (EWP definition) and the Centers for Disease Control/American Academy of Periodontology (CDC/AAP definition) were used to define severe periodontitis. Additionally, the periodontal inflamed surface area (PISA), reflecting the amount of inflamed periodontal tissue, was calculated using clinical periodontal parameters. Follow-up cognitive examinations for MCI diagnosis were performed by neurologists 1, 2, 3, and 5 years after baseline. Odds ratios (ORs) for MCI according to the presence of periodontitis and periodontal inflammation at baseline were calculated using multilevel mixed-effects logistic regression. RESULTS: At baseline, 56.4% and 27.4% of the participants had severe periodontitis by the EWP and CDC/AAP definitions, respectively. After adjusting for follow-up period and other baseline health characteristics (age, sex, smoking status, educational level, physical activity level, obesity, depression, and diabetes), severe periodontitis by either definition was significantly associated with MCI (for the EWP definition: adjusted OR = 3.58, 95% confidence interval [CI] = 1.45-8.87; for the CDC/AAP definition: adjusted OR = 2.61, 95% CI = 1.08-6.28). Periodontal inflammation assessed by PISA was also significantly associated with a higher OR for MCI (adjusted OR = 1.05, 95% CI = 1.01-1.10, per 10-mm2 increase in PISA). CONCLUSION: Severe periodontitis and periodontal inflammation were associated with incident MCI among older community-dwelling men and women.
• 高齢者における咀嚼能力、食欲とサルコペニアとの関連 3年間の前向きコホート研究
  妹尾 宗一郎; 岩崎 正則; 正木 千尋; 近藤 祐介; 安細 敏弘; 細川 隆司
  日本補綴歯科学会誌, 11, 特別号, 314, 314, (公社)日本補綴歯科学会, May 2019
  Japanese
• Predicting gingivitis using visual gingival redness examination on 11 years old Japanese schoolchildren: A ROC analysis
  Lisdrianto Hanindriyo; Akihiro Yoshihara; Hiro-O. Ito; Kana Suwama; Satoko Kakuta; Makoto Fukui; Masanori Iwasaki; Naofumi Tamaki; Toshihiro Ansai
  Pediatric Dental Journal, 29, 2, 66, 71, May 2019, [Peer-reviewed]
• Rising rural body-mass index is the main driver of the global obesity epidemic in adults.
  NCD Risk Factor Collaboration; NCD-RisC
  Nature, 569, 7755, 260, 264, May 2019, [Peer-reviewed], [International Magazine]
  English, Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3-6. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.
• バス運転手における糖尿病、不眠度、食習慣および歯周病の関連(第一報)
  芹田 千穂; 片岡 正太; 廣島屋 貴俊; 茂山 博代; 角田 聡子; 福原 正代; 正木 千尋; 岩崎 正則; 安細 敏弘; 細川 隆司
  口腔衛生学会雑誌, 69, 増刊, 162, 162, (一社)日本口腔衛生学会, Apr. 2019
  Japanese
• 動脈硬化と歯周病との関連 地域在住高齢者を対象とした横断研究
  佐藤 美寿々; 岩崎 正則; 皆川 久美子; 山賀 孝之; 小川 祐司
  口腔衛生学会雑誌, 69, 増刊, 164, 164, (一社)日本口腔衛生学会, Apr. 2019
  Japanese
• Effect of chronic kidney disease on progression of clinical attachment loss in older adults: A 4-year cohort study.
  Iwasaki M; Taylor GW; Sato M; Minagawa K; Ansai T; Yoshihara A
  Journal of periodontology, 90, 8, 826, 833, Feb. 2019, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, BACKGROUND: People with chronic kidney disease (CKD) may have an increased risk of periodontal disease, but longitudinal evidence is sparse. METHODS: This 4-year cohort study assessed the association between CKD and changes in periodontal health status, defined by attachment loss (AL) progression, among older adults. Participants were 388 community-dwelling Japanese adults who were 70 years old at baseline with 7053 teeth. Estimated glomerular filtration rate (eGFR) was calculated by using baseline serum creatinine concentration. AL at six sites for every tooth was recorded at baseline and follow-up examinations. Multilevel logistic regression models estimated the tooth-specific risk of AL progression (≥1 site exhibiting a ≥3 mm increase in AL) with baseline CKD (eGFR < 60 mL/min/1.73 m2 ) as the principal exposure. RESULTS: At baseline, 27.8% of the study population (108/388 participants) had CKD. After 4 years, 21.8% of the studied teeth (1537/7053 teeth) exhibited AL progression. After applying inverse probability weighting and adjusting for potential confounders, including sex, use of devices for interdental cleaning, smoking, diabetes, tooth location, abutment for a removable denture, and highest AL, CKD was associated with significantly higher odds of AL progression (adjusted odds ratio: 1.73; 95% confidence interval: 1.15-2.60). CONCLUSIONS: The results suggest that CKD increases the risk of periodontal disease progression in older community-dwelling Japanese adults. Additional studies with more complete information, as well as in other geographic areas and age groups, are necessary to further generalize the findings.
• The Association between Tongue Pressure and Nutrient Intake in Adults Receiving Home Care Services
  YAMADA Shima; IWASAKI Masanori; KAKUTA Satoko; KATAOKA Shota; SAKAI Rie; HAMASAKI Tomoko; OKADA Keiko; TSUTSUI Syuichi; ANSAI Toshihiro
  JOURNAL OF DENTAL HEALTH, 69, 4, 189, 197, Japanese Society for Oral Health, 2019
  Japanese,

   This cross-sectional study aimed to elucidate the relationship between tongue pressure and nutrient intake in adults receiving home care services.

   The study population consisted of 95 adults (mean age, 84.6 years) who received home care services covered by long-term care insurance. Tongue pressure was measured using a tongue pressure measurement device. A tongue pressure <20 kPa was defined as a low tongue pressure. Daily dietary intake of the following five nutrients was estimated using a brief-type self-administered diet history questionnaire: protein, vitamin D, vitamin E, vitamin C, and folate. According to the criteria proposed by a previous study or the Recommended Dietary Allowance (RDA) / the Adequate Intake (AI) proposed by the Dietary Reference Intakes for Japanese (2015), the above five nutrients were scored as low (1 point) or acceptable (0 point). The sum of the individual scores (0–5 points) gave the quantity of nutrients with levels below the proposed criteria. Using this score as an outcome, the association between tongue pressure and nutrient intake was estimated by Poisson regression analysis.

   A low tongue pressure was found to be significantly associated with nutrient levels below the proposed criteria (rate ratio = 1.8, 95% confidence interval = 1.2–2.7 for the criteria proposed by the previous study; rate ratio = 1.7, 95% confidence interval = 1.2–2.5 for the RDA or AI criteria).

   These findings suggest that low tongue pressure results in insufficient nutrient intake in adults receiving home care services.

• 小児の歯肉炎評価におけるGCFの応用に関する検討
  角田 聡子; 邵 仁浩; 葭原 明弘; 福井 誠; 岩崎 正則; 諏訪間 加奈; 鶴田 実穂; 平山 綾; 片岡 正太; 茂山 博代; 横田 誠; 牛島 直文; 玉木 直文; 伊藤 博夫; 安細 敏弘
  口腔衛生学会雑誌, 69, 1, 19, 26, (一社)日本口腔衛生学会, Jan. 2019, [Peer-reviewed]
  Japanese
• Ten-year survival of immediate-loading implants in fully edentulous mandibles in the Japanese population: a multilevel analysis.
  Kazuhiko Kaneda; Yusuke Kondo; Chihiro Masaki; Taro Mukaibo; Shintaro Tsuka; Akiko Tamura; Fumiko Aonuma; Kouhei Shinmyouzu; Masanori Iwasaki; Toshihiro Ansai; Ryuji Hosokawa
  Journal of prosthodontic research, 63, 1, 35, 39, Jan. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal, PURPOSE: To evaluate the long-term clinical results of and risk factors for immediate-loading implant treatment of completely edentulous mandibles. METHODS: We retrospectively studied 220 implants in 52 patients who received immediate-loading implants in fully edentulous mandibles. Kaplan-Meier survival analyses, log-rank tests, and multilevel mixed-effects parametric survival analysis was used for statistical analyses. RESULTS: Thirteen of implants in seven patients failed, and the 10-year cumulative implant survival rate was 93.9 % and significantly (p=0.049) higher in women than in men. None of the predictor variables were significantly associated with implant survival, although sex tended to be associated with implant survival. CONCLUSIONS: Immediate-loading implant treatment for completely edentulous mandibles had acceptable clinical results in the long term. Although we could not identify significant risk factors, we established a multilevel mixed-effects parametric survival analysis with the immediate-loading implant survival data.
• Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community-dwelling elderly.
  Akihiro Yoshihara; Noboru Kaneko; Masanori Iwasaki; Kaname Nohno; Hideo Miyazaki
  Journal of clinical periodontology, 45, 6, 672, 679, Jun. 2018, [Peer-reviewed], [International Magazine]
  English, OBJECTIVES: The aim of this study was to investigate the possible correlation between vitamin D receptor (VDR) gene polymorphism and susceptibility to chronic kidney disease (CKD) and periodontal disease. MATERIAL AND METHODS: This study analysed 345 participants, who were all 79 years of age. Kidney function levels were determined based on the estimated glomerular filtration rate (eGFR; non-reduced function: ≥60 and reduced function: <60 ml min-1  1.73 m-2 ). VDR TaqI genotyping was also studied. We calculated the periodontal inflamed surface area (PISA). After classifying participants into quartile groups according to eGFR or PISA values, the subjects were then split into two groups (highest quartile versus the other three groups combined). Multiple logistic regression analysis was performed to evaluate the odds ratios between the eGFR and VDR TaqI genotype with the different PISA groups. The eGFR was set as the dependent variable while the VDR TaqI genotype, HbA1C, gender, smoking habits and body mass index were defined as independent variables. RESULTS: A significant association was observed between the VDR TaqI genotype and eGFR in the PISA high group (odds ratio = 3.97, p = .027). CONCLUSION: Study results suggest that VDR TaqI genotype might be associated with CKD during inflammatory conditions caused by periodontal disease.
• Hyposalivation and 10-year all-cause mortality in an elderly Japanese population
  Masanori Iwasaki; Wenche S. Borgnakke; Akihiro Yoshihara; Kayoko Ito; Hiroshi Ogawa; Kaname Nohno; Misuzu Sato; Kumiko Minagawa; Toshihiro Ansai; Hideo Miyazaki
  Gerodontology, 35, 2, 87, 94, Blackwell Munksgaard, 01 Jun. 2018, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Association between objectively measured chewing ability and frailty: A cross-sectional study in central Thailand.
  Masanori Iwasaki; Yumi Kimura; Kwanchit Sasiwongsaroj; Matana Kettratad-Pruksapong; Sutee Suksudaj; Yasuko Ishimoto; Nai-Yuan Chang; Ryota Sakamoto; Kozo Matsubayashi; Yupin Songpaisan; Hideo Miyazaki
  Geriatrics & gerontology international, 18, 6, 860, 866, Jun. 2018, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
  English, Scientific journal, AIM: Limited data are available on the association between oral function and frailty, especially in developing countries. Additionally, the association between objectively assessed chewing function and frailty has not been well studied. The present cross-sectional study tested the hypothesis that objectively measured poor chewing ability is associated with frailty in community-dwelling older Thai adults. METHODS: The study population comprised 141 people in Nakhon Pathom, Thailand (median age 72 years). Demographic and clinical data were collected at a community center. Participants were asked to chew a gum designed for assessing chewing ability. The differences in gum color before and after chewing (ΔE*ab) were calculated and used as the exposure variable, where a lower ΔE*ab indicates lower chewing ability. Frailty phenotypes were defined by weakness, slowness, weight loss, low physical activity level and exhaustion components, and used as the outcome variable. Participants with three or more components were considered frail, and those with one or two components were considered pre-frail. Ordinal logistic regression analyses were carried out to assess the association of objective chewing ability with frailty. RESULTS: Of the 141 participants, 32 (22.7%) were categorized as frail and 78 (55.3%) as pre-frail. In the analysis adjusted for demographic and health characteristics, the adjusted odds ratio of the presence and severity of frailty was significantly higher in participants with lower ΔE*ab (adjusted odds ratio for one decrease in ΔE*ab 1.05, 95% confidence interval 1.01-1.10, P = 0.03). CONCLUSIONS: Objectively measured chewing ability was significantly associated with frailty in community-dwelling older Thai adults. Geriatr Gerontol Int 2018; 18: 860-866.
• Relationship between autoantibody associated with rheumatoid arthritis and tooth loss.
  Yuko Hayashi; George Taylor; Akihiro Yoshihara; Masanori Iwasaki; Stuart A Gansky; Hideo Miyazaki
  Gerodontology, 21 May 2018, [Peer-reviewed], [International Magazine]
  English, INTRODUCTION: This study evaluated the relationship between serum Rheumatoid Factor (RF) levels and tooth loss in a community-dwelling elderly Japanese women. It was hypothesised that women with high baseline RF levels would experience greater tooth loss over 10 years than age-matched women with lower baseline serum RF levels. MATERIALS AND METHODS: The study population consisted of 197 women aged 70 years with ≥12 teeth at baseline. One hundred and twenty-four participants completed a 10-year follow-up and were divided into 2 groups according to their baseline serum RF levels as follows: RF negative (<15 U/mL; n = 114) and RF positive (>15 U/mL; n = 10). Negative binomial regression was used to investigate the relationship between baseline RFs and tooth lost over the 10-year period. RF and its interaction with the baseline number of teeth were independent variables, with 9 other adjustment covariates. RESULTS: Baseline RFs were significantly associated with tooth loss (P = .035). In addition, a statistical interaction between baseline RFs and baseline number of teeth was identified (P = .023), modifying the association between RFs and tooth loss. The adjusted incidence rate ratio (IRR) for RF-positive participants with 21 baseline teeth was 1.88 (95% confidence interval (95% CI): 0.76, 4.65). IRRs obtained for participants who had 25 baseline teeth (3.02; 95% CI: 1.03, 8.83) or 30 baseline teeth (5.47; 95% CI: 1.29, 23.13) suggested that RF-positive participants with a high number of baseline teeth would exhibit greater tooth loss than RF-negative participants. CONCLUSION: High serum RF levels were associated with a greater IRR for future tooth loss in elderly Japanese women.
• Effect of lifestyle on 6-year periodontitis incidence or progression and tooth loss in older adults.
  Iwasaki M; Borgnakke WS; Ogawa H; Yamaga T; Sato M; Minagawa K; Ansai T; Yoshihara A; Miyazaki H
  Journal of clinical periodontology, 45, 8, 896, 908, May 2018, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, AIM: To evaluate the longitudinal association of combined healthy lifestyle factors with incidence or progression of periodontitis and tooth loss in older adults. MATERIALS AND METHODS: This 6-year study included 374 Japanese 70-year olds with 7,157 teeth, from a source eligible baseline population of 554 individuals. Four lifestyle factors-cigarette smoking, physical activity, relative weight, and dietary quality-were scored as healthy (1 point) or unhealthy (0 point). Adding the individual scores generated the "healthy lifestyle score" (0-4 points). Multilevel mixed-effects logistic regression models were applied to evaluate tooth-specific associations between the baseline healthy lifestyle score and the incidence or progression of periodontitis (increase in clinical attachment loss ≥3 mm) and tooth loss. RESULTS: After 6 years, 19.0% of the teeth exhibited periodontitis incidence or progression and 8.2% were lost. Compared with a healthy lifestyle score of 0-1 (least healthy), the highest score (4 points) was associated with a significantly lower tooth-specific risk of periodontitis (adjusted odds ratio = 0.32; 95% confidence interval: 0.16-0.62) and tooth loss (adjusted odds ratio = 0.42; 95% confidence interval: 0.23-0.77). CONCLUSIONS: Simultaneous adherence to multiple healthy lifestyle factors significantly lowers the risk of incidence or progression of periodontitis and tooth loss in older adults.
• Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants
  NCD Risk Factor Collaboration; NCD-RisC
  International Journal of Epidemiology, 47, 3, 872, 883i, Oxford University Press (OUP), May 2018, [Peer-reviewed]
  Scientific journal
• 納豆摂取と歯の喪失との関連 地域在住閉経後女性を対象とした縦断研究
  佐藤 美寿々; 岩崎 正則; 皆川 久美子; 葭原 明弘; 宮崎 秀夫
  口腔衛生学会雑誌, 68, 増刊, 112, 112, (一社)日本口腔衛生学会, Apr. 2018
  Japanese
• 高次生活機能の加齢に伴う変化の軌跡と歯の本数の関連についての縦断研究
  岩崎 正則; 佐藤 美寿々; 皆川 久美子; 安細 敏弘; 葭原 明弘; 小川 祐司; 宮崎 秀夫
  口腔衛生学会雑誌, 68, 増刊, 112, 112, (一社)日本口腔衛生学会, Apr. 2018
  Japanese
• Dentition status and frailty in community-dwelling older adults: A 5-year prospective cohort study
  Masanori Iwasaki; Akihiro Yoshihara; Misuzu Sato; Kumiko Minagawa; Mieko Shimada; Mamoru Nishimuta; Toshihiro Ansai; Yutaka Yoshitake; Hideo Miyazaki
  Geriatrics and Gerontology International, 18, 2, 256, 262, Blackwell Publishing, 01 Feb. 2018, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Association between Eating Assessment Tool-10 (EAT-10) and the Health, Dental, and Nutritional Status of Elderly Individuals Living at Home
  AKIYAMA Rika; HAMASAKI Tomoko; SAKAI Rie; IWASAKI Masanori; KAKUTA Satoko; SOH Inho; YOSHIHARA Akihiro; MIYAZAKI Hideo; ANSAI Toshihiro
  JOURNAL OF DENTAL HEALTH, 68, 2, 76, 84, Japanese Society for Oral Health, 2018
  Japanese,

   This study investigated the relationship between dysphagia and the nutritional status of elderly individuals living at home when screened with Eating Assessment Tool-10 (EAT-10). A total of 129 participants (62 males, 67 females, aged 85 years) were surveyed. Participants were sent a questionnaire by mail and asked to complete and return it to the authors. Assessments included in the questionnaire were EAT-10, the self-reported number of teeth, Short-form Mini Nutritional Assessment (MNA-SF), a subjective health evaluation, Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-Index of Competence), Oral Health Impact Profile-49 (OHIP), and number of foods that can be masticated. To evaluate variation in the study's variables, the analysis was based on established scores of EAT-10: those suspected of having dysphagia score above three; those with no suspicion of dysphagia score below two.

   When screened with EAT-10, 52.7% of the participants were classified as being suspected of having dysphagia. There were significant correlations between dysphagia and a low OHIP score (p<0.001), the number of foods that can be masticated (p<0.001), subjective health evaluation (p<0.001), and MNA-SF (p=0.007).

   Furthermore, logistic regression analysis revealed that the nutritional status was associated with dysphagia (p=0.043)．These findings suggest the association of dysphagia with malnutrition in elderly people living at home.

• Association of Eating Assessment Tool-10 Results with Oral Hygiene, Oral Function, and Nutritional Status of Elderly Individuals in Long-term Care Facility
  AKIYAMA Rika; ANSAI Toshihiro; HAMASAKI Tomoko; SAKAI Rie; KATAOKA Shota; KAKUTA Satoko; SOH Inho; TOMOE Miki; AWANO Shuji; IWASAKI Masanori
  JOURNAL OF DENTAL HEALTH, 68, 3, 128, 136, Japanese Society for Oral Health, 2018
  Japanese,

   In this study, we investigated the association of results obtained with Eating Assessment Tool-10 (EAT-10) and Repetitive Saliva Swallowing Test (RSST) with the oral hygiene, oral function, and nutritional status of elderly individuals. A total of 90 subjects (21 males, 69 females, average age: 86.0±7.2 years) were enrolled. We assessed the cleanliness of tooth surfaces as oral hygiene, mouth-opening capacity as the masticatory function, and Short-form Mini Nutritional Assessment (MNA-SF) findings as the nutritional status, as well as subjective symptoms related to swallowing. Associations between subjects with and without the risk of developing dysphagia were analyzed based on EAT-10 and RSST scores, while path analysis was also conducted. There were significant correlations of dysphagia assessed by EAT-10 with tooth surface cleanliness and the mouth-opening capacity, as well as the subjective symptoms of hard to swallow and choking. In addition, significant correlations of dysphagia assessed by RSST with the mouth-opening capacity, tongue movement, and number of chewable foods, as well as the subjective symptoms of hard to swallow and choking shown in MNA-SF findings were noted. Path analysis results indicated a weak association between EAT-10 and RSST, while there were significant paths from EAT-10 to tooth surface cleanliness and stains on the tongue, as well as the subjective symptoms of hard to swallow and choking, and significant paths or trends from RSST to tongue movement, number of chewable foods, and MNA-SF findings. The present results indicate that EAT-10 is influenced by factors related to oral hygiene and subjective symptoms, while factors influencing RSST are related to the masticatory function and nutritional status. It is suggested that findings obtained by screening with EAT-10 are correlated with those with RSST, although the specific characteristics are different.

• A Pilot Study of the Relationship between Whole-body Skeletal Muscle Mass and Tongue Pressure in ≥75-year-old Individuals Requiring Home-based Care Support
  HIROSHIMAYA Takatoshi; IWASAKI Masanori; SAKAI Rie; KAKUTA Satoko; HAMASAKI Tomoko; KATAOKA Shota; TSUTSUI Syuichi; ANSAI Toshihiro
  JOURNAL OF DENTAL HEALTH, 68, 3, 145, 152, Japanese Society for Oral Health, 2018
  Japanese,

   Tongue pressure is the force produced by contact between the anterior part of the hard palate and tongue, which is composed chiefly of muscle tissue. Tongue pressure is one of the objective indicators of oral function. Low whole-body skeletal muscle mass has been reported to be associated with functional impairment and physical disability. However, little is known about the relationship between whole-body skeletal muscle mass and oral function. This study aimed to elucidate the relationship between whole-body skeletal muscle mass and tongue pressure in individuals aged ≥75 years old requiring home-based support.

   This study included 64 individuals aged ≥75 years (average age = 86.4 years; 18 men and 46 women) who used home-based care support covered by long-term care insurance. Tongue pressure was measured using a tongue pressure measurement device. In addition, limb skeletal muscle mass was measured by a body composition analyzer. Subsequently, the skeletal muscle index (SMI) was calculated by dividing the absolute limb skeletal muscle mass by the height in meters squared. Then, the association between tongue pressure and SMI was estimated by robust regression analysis. Variables that showed a significant correlation with tongue pressure in univariate analysis were included as potential confounders in the multivariable model.

   Univariate analysis showed a significant positive correlation between SMI and tongue pressure. This remained significant after adjusting for potential confounders (regression coefficient=3.6; 95% confidence interval=1.6–5.5; p<0.01).

   In conclusion, this study demonstrated a significant positive correlation between whole-body skeletal muscle mass and tongue pressure in individuals aged ≥75 years old requiring home-based care support.

• Associations among Oral Function, Nutritional Status, and Nutrient Intake in Elderly Individuals Living at Home and Receiving Nursing Care
  SAKAI Rie; ANSAI Toshihiro; HAMASAKI Tomoko; KAKUTA Satoko; HIROSHIMAYA Takatoshi; SOH Inho; KATAOKA Shota; OKADA Keiko; TSUTSUI Syuichi; IWASAKI Masanori
  JOURNAL OF DENTAL HEALTH, 68, 4, 207, 218, Japanese Society for Oral Health, 2018
  Japanese,

   We investigated associations among the oral function, nutritional status, and nutrient intake in elderly individuals living at home and receiving nursing care. The subjects of this study were 63 individuals (25 males, 38 females) aged 65 years or older (average: 83.5±6.8 years). All subjects agreed to undergo a dental examination and answer survey questions regarding their diet. Using the Revised Oral Assessment Guide, we graded 8 intraoral items with a score of 1-3 points to determine the oral function. A total score of 8 points indicated a good function, 9-12 points indicated a mild decrease, and 13 or more indicated a severe decrease in function. The latter 2 groups were combined into a decreased group (oral function decrease of 9 or more points). Age, body mass index, skeletal muscle index, grip strength, and Mini Nutritional Assessment - Short Form results were not significantly different between the good and decreased groups. The good group showed significantly higher values of Alb (≥4.0 g/dL) and tongue pressure (≥35 kPa), and there were also significantly fewer individuals who required nursing care, based on recognition independence, as compared with the decreased group. Date on nutrient intake were extracted from answers to a brief-type self-administered diet history questionnaire, and they were also compared between the groups. The good group contained a significantly higher number of individuals who ate more than the recommended dietary allowance of protein for individuals aged 70 years or older, and had a lower intake of vitamin C. Regarding the nutrient food group intake, subjects in the good group consumed root crops, legumes, and fatty fish significantly more frequently, while those in the decreased group showed a significantly more frequent intake of potatoes, citrus fruits, and confectionery. Associations among a lower oral function, the nutrition status, and food group intake were noted in our results. Our study suggested that the appropriate management of oral care and nutrition can promote a better oral condition, which is important for effective care and living support for elderly individuals. In addition, collaboration between dental and diet professionals is considered helpful.

• 視診による歯肉炎評価の有用性
  渡辺 真光; 葭原 明弘; 諏訪間 加奈; 角田 聡子; 岩崎 正則; 安細 敏弘; 宮崎 秀夫
  口腔衛生学会雑誌, 68, 1, 36, 37, (一社)日本口腔衛生学会, Jan. 2018
  Japanese
• 地域在住高齢者における現在歯数および義歯の使用状況・主観的評価とフレイルとの関連についての横断研究
  佐藤美寿々; 岩崎正則; 皆川久美子; 小川祐司; 山賀孝之; 葭原明弘; 宮崎秀夫
  口腔衛生会誌, 68, 2, 68, 75, (一社)日本口腔衛生学会, 2018, [Peer-reviewed]
  Japanese, Scientific journal
• A 5-year longitudinal study of association of maximum bite force with development of frailty in community-dwelling older adults
  Iwasaki M; A. Yoshihara; N. Sato; M. Sato; K. Minagawa; M. Shimada; M. Nishimuta; T. Ansai; Y. Yoshitake; T. Ono; H. Miyazaki
  JOURNAL OF ORAL REHABILITATION, 45, 1, 17, 24, Jan. 2018, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Periodontal disease and pneumonia mortality in haemodialysis patients: A 7-year cohort study
  Masanori Iwasaki; George W. Taylor; Shuji Awano; Akihiro Yoshida; Shota Kataoka; Toshihiro Ansai; Hidetoshi Nakamura
  Journal of Clinical Periodontology, 45, 1, 38, 45, Blackwell Munksgaard, 01 Jan. 2018, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults
  NCD Risk Factor Collaboration; NCD-RisC
  LANCET, 390, 10113, 2627, 2642, Dec. 2017, [Peer-reviewed]
  English, Scientific journal
• Relationships among sense of coherence, oral health status, nutritional status and care need level of older adults according to path analysis.
  Nanae Dewake; Tomoko Hamasaki; Rie Sakai; Shima Yamada; Yuko Nima; Miki Tomoe; Satoko Kakuta; Masanori Iwasaki; Inho Soh; Yoshihiro Shimazaki; Toshihiro Ansai
  Geriatrics & gerontology international, 17, 11, 2083, 2088, Nov. 2017, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, AIM: Sense of coherence (SOC) is a measurement of ability of an individual to cope with psychological stress and remain in good health. The aim of the present study was to examine the relationships among SOC score, oral health status, nutritional status and care need level of older adults using path analysis. METHODS: We enrolled 53 older adults (17 men and 36 women) who were attending a day care service (mean age 80.4 ± 6.5 years). SOC was assessed using a 13-item, seven-scale instrument. Oral health status (number of present teeth, denture use) and nutritional status (assessed with Mini-Nutritional Assessment Short-Form) were also evaluated. Path analysis was used to examine the relationship of SOC with other related factors, including care need level. RESULTS: The mean SOC score was 57.0 ± 13.9. Mini-Nutritional Assessment Short-Form results showed that one participant (1.8%) was malnourished, 26 (49.1%) were at risk of malnutrition and 26 (49.1%) had normal nutritional status. Participants with high SOC scores showed a strong positive attitude, had a relatively large number of teeth, were in good nutritional condition and showed low care need levels. CONCLUSIONS: The present results showed that maintaining a high SOC level and good oral health help to reduce care need levels in older adults, and also prevent a worsening of their nutritional condition. Geriatr Gerontol Int 2017; 17: 2083-2088.
• 政策声明 認知症に対する口腔保健の予防的役割
  葭原 明弘; 安藤 雄一; 深井 穫博; 安細 敏弘; 伊藤 博夫; 佐々木 健; 山本 龍生; 皆川 久美子; 宮本 茜; 岩崎 正則; 竹内 研時; 日本口腔衛生学会; 日本口腔衛生学会疫学研究委員会および政策声明委員会
  口腔衛生学会雑誌, 67, 4, 251, 259, (一社)日本口腔衛生学会, Oct. 2017
  Japanese
• Relationship between renal function and periodontal disease in community-dwelling elderly women with different genotypes.
  Akihiro Yoshihara; Noriko Sugita; Masanori Iwasaki; Yanming Wang; Hideo Miyazaki; Hiromasa Yoshie; Kazutoshi Nakamura
  Journal of clinical periodontology, 44, 5, 484, 489, May 2017, [Peer-reviewed], [International Magazine]
  English, Scientific journal, OBJECTIVES: The aim of this study was to examine the association between periodontal disease and renal function in elderly women with different genotypes. MATERIAL AND METHODS: A total of 332 postmenopausal never-smoking women were analysed. Poor renal function was defined as serum cystatin C > 0.91 mg/l. Periodontal disease markers such as periodontal inflamed surface area (PISA) were evaluated. Selected variables, including PISA quartile, body mass index (BMI), HbA1C and age in Arg allele carriers and non-carriers based on the beta-3 adrenergic receptor, or between Ala allele carriers and non-carriers based on peroxisome proliferator-activated receptor gamma, were analysed using multiple logistic regression analysis. RESULTS: The odds ratios of serum cystatin C level and PISA (fourth quartile) were significantly positive for both Arg (2.52; p = 0.035) and Ala allele non-carriers (2.36; p = 0.021). A significant association was also found between serum cystatin C level and BMI for both Arg (1.18; p = 0.001) and Ala allele non-carriers (1.12; p = 0.003). CONCLUSION: The results of this study suggest that periodontal inflammation might be associated with renal function. Furthermore, in both the Arg and Ala allele non-carriers, the associations between BMI and PISA for renal function became stronger.
• Malnutrition and Oral Disease in the Elderly––Is There Any Bidirectional Relationship?
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Hideo Miyazaki
  Current Oral Health Reports, 4, 2, 70, 78, Springer Science and Business Media LLC, 21 Apr. 2017
  Scientific journal
• 80歳地域住民における歯周病と糖尿病の生命予後への影響
  田上 綾香; 園木 一男; 秋房 住郎; 福原 正代; 粟野 秀慈; 角田 聡子; 邵 仁浩; 岩崎 正則; 安細 敏弘
  日本歯周病学会会誌, 59, 1, 19, 27, (NPO)日本歯周病学会, Apr. 2017
  Japanese
• 透析患者における唾液分泌量低下と健康関連Quality of Lifeの関連
  有永 靖; 岩崎 正則; 粟野 秀慈; 伊藤 加代子; 吉田 明弘; 角田 聡子; 邵 仁浩; 安細 敏弘
  口腔衛生学会雑誌, 67, 2, 64, 69, (一社)日本口腔衛生学会, Apr. 2017, [Peer-reviewed], [Corresponding author]
  Japanese
• Relationships between pathologic subjective halitosis, olfactory reference syndrome, and social anxiety in young Japanese women.
  Miho Tsuruta; Toru Takahashi; Miki Tokunaga; Masanori Iwasaki; Shota Kataoka; Satoko Kakuta; Inho Soh; Shuji Awano; Hiromi Hirata; Masaharu Kagawa; Toshihiro Ansai
  BMC psychology, 5, 1, 7, 7, 14 Mar. 2017, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Pathologic subjective halitosis is known as a halitosis complaint without objective confirmation of halitosis by others or by halitometer measurements; it has been reported to be associated with social anxiety disorder. Olfactory reference syndrome is a preoccupation with the false belief that one emits a foul and offensive body odor. Generally, patients with olfactory reference syndrome are concerned with multiple body parts. However, the mouth is known to be the most common source of body odor for those with olfactory reference syndrome, which could imply that the two conditions share similar features. Therefore, we investigated potential causal relationships among pathologic subjective halitosis, olfactory reference syndrome, social anxiety, and preoccupations with body part odors. METHODS: A total of 1360 female students (mean age 19.6 ± 1.1 years) answered a self-administered questionnaire regarding pathologic subjective halitosis, olfactory reference syndrome, social anxiety, and preoccupation with odors of body parts such as mouth, body, armpits, and feet. The scale for pathologic subjective halitosis followed that developed by Tsunoda et al.; participants were divided into three groups based on their scores (i.e., levels of pathologic subjective halitosis). A Bayesian network was used to analyze causal relationships between pathologic subjective halitosis, olfactory reference syndrome, social anxiety, and preoccupations with body part odors. RESULTS: We found statistically significant differences in the results for olfactory reference syndrome and social anxiety among the various levels of pathologic subjective halitosis (P < 0.001). Residual analyses indicated that students with severe levels of pathologic subjective halitosis showed greater preoccupations with mouth and body odors (P < 0.05). Bayesian network analysis showed that social anxiety directly influenced pathologic subjective halitosis and olfactory reference syndrome. Preoccupations with mouth and body odors also influenced pathologic subjective halitosis. CONCLUSIONS: Social anxiety may be a causal factor of pathologic subjective halitosis and olfactory reference syndrome.
• Association between tooth loss and medical costs related to stroke in healthy older adults aged over 75 years in Japan
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Toshihiro Ansai; Hideo Miyazaki
  GERIATRICS & GERONTOLOGY INTERNATIONAL, 17, 2, 202, 210, Feb. 2017, [Peer-reviewed], [Lead author, Corresponding author]
  English, Scientific journal
• Periodontitis and health-related quality of life in hemodialysis patients
  Masanori Iwasaki; Wenche S. Borgnakke; Shuji Awano; Akihiro Yoshida; Tomoko Hamasaki; Gou Teratani; Shota Kataoka; Satoko Kakuta; Inho Soh; Toshihiro Ansai; Hidetoshi Nakamura
  Clinical and Experimental Dental Research, 3, 1, 13, 18, Wiley-Blackwell, 01 Feb. 2017, [Peer-reviewed]
  English, Scientific journal
• Effects of periodontal disease and diabetes mellitus on the life prognosis in an 80-year-old community population
  Tagami Ayaka; Sonoki Kazuo; Akifusa Sumio; Fukuhara Masayo; Awano Shuji; Kakuta Satoko; Soh Inho; Iwasaki Masanori; Ansai Toshihiro
  Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology), 59, 1, 19, 27, JAPANESE SOCIETY OF PERIODONTOLOGY, 2017
  Japanese, To determine whether presence of periodontal disease and diabetes mellitus influence the life prognosis in 80-year-old subjects, oral and medical examinations were conducted in 697 residents of Fukuoka Prefecture of Japan who were 80 years old in 1997, and the dates and causes of death among these residents were determined 5 years and 12 years later. We analyzed the all-cause death, pneumonia death, cardiovascular-disease death and cancer death rates between the subjects with mild periodontal disease (no. of teeth with a probing depth ≥4 mm = 0-4; n = 526) and those with severe periodontal disease (no. of teeth with a probing depth ≥4 mm ≥5; n = 169), and also between the 77 diabetic patients (history of diabetes mellitus and/or random blood sugar levels ≥200 mg/dl) and 620 non-diabetic subjects. The relative risk of pneumonia death in the severe periodontal disease group was 2.28 times higher at the 12-year follow-up as compared to that in the mild periodontal disease group. On the other hand, the relative risks of cardiovascular-disease death and cancer death were not affected by the severity of the periodontal disease. The relative risks of pneumonia death and all-cause death determined at the 12-year follow-up were higher in the diabetic patients than in the non-diabetic subjects. When we analyzed four other subject groups (mild periodontal disease+non-diabetic, mild periodontal disease+diabetic, severe periodontal disease+non-diabetic, and severe periodontal disease+diabetic), the relative risk of pneumonia death at the 12-year follow-up was 2.90 times higher in the severe periodontal disease+non-diabetic group, 5.93 times higher in the mild periodontal disease+diabetic group, and 6.20 times higher in the severe periodontal disease+diabetic group as compared to that in the mild periodontal disease+non-diabetic group. The relative risks of all-cause death in the mild periodontal disease+diabetic group and severe periodontal disease+diabetic group were 2.24 times higher and 2.21 times higher, respectively, as compared to the relative risk in the mild periodontal disease+non-diabetic group. In the 80-year-old study population, it appeared that severe periodontal disease and diabetes mellitus independently increased the risk of pneumonia death, but when diabetes mellitus was present concomitantly with severe periodontal disease, the risk of pneumonia death appeared to be further increased.
• Do Community-dwelling 75-year-old People with 20 or More Teeth Have a Healthy Dietary Pattern?
  KIMURA Hideki; WATANABE Tomoko; SUZUKI Ayuho; IWASAKI Masanori; YOSHIHARA Akihiro; OGAWA Hiroshi; MIYAZAKI Hideo
  JOURNAL OF DENTAL HEALTH, 67, 3, 172, 180, Japanese Society for Oral Health, 2017
  Japanese,

  The oral health of elderly people is not only important in the maintenance of solid nutrition and articulation but also for their quality of life (QOL). The presence of ≥20 teeth is one of the criteria in the maintenance of the oral function and general health. In 2015, the Ministry of Health, Labour and Welfare of Japan announced the guideline called "Healthy Diet", which supports the longevity of Japanese people. We examined the association between the presence of ≥20 teeth and healthy diet among 75-year-old people. This study included 338 people aged 75 years who participated in the Niigata Elderly Study (2003), in which oral examination, medical checkup, and a brief-type self-administered diet history questionnaire (BDHQ) survey had been carried out. A healthy dietary pattern was defined according to Japan's healthy diet guideline. The healthy diet assumes that one meal consists of three main dishes: grain dish, fish or meat dish, and vegetable dish. For each dish, there are lower and upper limits on the amount of food consumed per meal. For this reason, we set the per-day lower limit as equal to three times the lower limit for a meal. In this study, the sufficiency group satisfied all three dish divisions (i.e., those who achieved a healthy dietary pattern), and the insufficiency group did not meet at least one dish division. The association between the presence of ≥20 teeth and a healthy dietary pattern was evaluated using multivariable logistic regression. As a result, individuals with ≥20 teeth had significantly higher odds of having a healthy dietary pattern (adjusted odds ratio, 1.7; 95% confidence interval: 1.1–2.6). In conclusion, our results suggest that there is a relationship between the presence of ≥20 teeth and meal patterns in elderly people.

• Malnutrition and oral disease in the elderly – is there any bidirectional relationship?
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Hideo Miyazaki
  Current Oral Health Reports, 4, 2, 70, 78, 2017, [Peer-reviewed], [Invited], [Lead author]
• The association between dentition status and sarcopenia in Japanese adults aged 75years
  M. Iwasaki; Y. Kimura; H. Ogawa; T. Wada; R. Sakamoto; Y. Ishimoto; M. Fujisawa; K. Okumiya; T. Ansai; H. Miyazaki; K. Matsubayashi
  JOURNAL OF ORAL REHABILITATION, 44, 1, 51, 58, Jan. 2017, [Peer-reviewed]
  English, Scientific journal
• Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants
  NCD Risk Factor Collaboration; NCD-RisC
  LANCET, 389, 10064, 37, 55, Jan. 2017, [Peer-reviewed]
  English, Scientific journal
• Longitudinal association of dentition status with dietary intake in Japanese adults aged 75 to 80 years
  Iwasaki M; A. Yoshihara; H. Ogawa; M. Sato; K. Muramatsu; R. Watanabe; T. Ansai; H. Miyazaki
  JOURNAL OF ORAL REHABILITATION, 43, 10, 737, 744, Oct. 2016, [Peer-reviewed]
  English, Scientific journal
• Longitudinal relationship of severe periodontitis with cognitive decline in older Japanese
  Iwasaki M; A. Yoshihara; Y. Kimura; M. Sato; T. Wada; R. Sakamoto; Y. Ishimoto; E. Fukutomi; W. Chen; H. Imai; M. Fujisawa; K. Okumiya; G. W. Taylor; T. Ansai; H. Miyazaki; K. Matsubayashi
  JOURNAL OF PERIODONTAL RESEARCH, 51, 5, 681, 688, Oct. 2016, [Peer-reviewed]
  English, Scientific journal
• Bidirectional relationship between renal function and periodontal disease in older Japanese women.
  Akihiro Yoshihara; Masanori Iwasaki; Hideo Miyazaki; Kazutoshi Nakamura
  Journal of clinical periodontology, 43, 9, 720, 6, Sep. 2016, [Peer-reviewed], [International Magazine]
  English, OBJECTIVES: The purpose of this study was to evaluate the reciprocal effects of chronic kidney disease (CKD) and periodontal disease. MATERIAL AND METHODS: A total of 332 postmenopausal never smoking women were enrolled, and their serum high-sensitivity C-reactive protein, serum osteocalcin and serum cystatin C levels were measured. Poor renal function was defined as serum cystatin C > 0.91 mg/l. Periodontal disease markers, including clinical attachment level and the periodontal inflamed surface area (PISA), were also evaluated. Logistic regression analysis was conducted to evaluate the relationships between renal function and periodontal disease markers, serum osteocalcin level and hsCRP level. The prevalence-rate ratios (PRRs) on multiple Poisson regression analyses were determined to evaluate the relationships between periodontal disease markers and serum osteocalcin, serum cystatin C and serum hsCRP levels. RESULTS: On logistic regression analysis, PISA was significantly associated with serum cystatin C level. The odds ratio for serum cystatin C level was 2.44 (p = 0.011). The PRR between serum cystatin C level and periodontal disease markers such as number of sites with clinical attachment level ≥6 mm was significantly positive (3.12, p < 0.001). Similar tendencies were shown for serum osteocalcin level. CONCLUSION: This study suggests that CKD and periodontal disease can have reciprocal effects.
• Cystatin C-based estimated glomerular filtration rate and periodontitis
  Masanori Iwasaki; George W. Taylor; Misuzu Sato; Kazutoshi Nakamura; Akihiro Yoshihara; Hideo Miyazaki
  GERODONTOLOGY, 33, 3, 328, 334, Sep. 2016, [Peer-reviewed]
  English, Scientific journal
• Maximum bite force at age 70 years predicts all-cause mortality during the following 13 years in Japanese men
  Iwasaki M; A. Yoshihara; N. Sato; M. Sato; G. W. Taylor; T. Ansai; T. Ono; H. Miyazaki
  JOURNAL OF ORAL REHABILITATION, 43, 8, 565, 574, Aug. 2016, [Peer-reviewed]
  English, Scientific journal
• Association between periodontitis and medical expenditure in older adults: A 33-month follow-up study.
  Misuzu Sato; Masanori Iwasaki; Akihiro Yoshihara; Hideo Miyazaki
  Geriatrics & gerontology international, 16, 7, 856, 64, Jul. 2016, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, AIM: Along with rapid aging, medical expenditure for older adults has been increasing in Japan. Research has shown that periodontitis is a useful predictor for excess medical expenditure; however, limited information is available on the elderly population after adequately considering confounding factors. The aim of the present study was to evaluate the association between periodontitis and long-term medical expenditure in elderly Japanese. METHODS: Baseline health and periodontal examinations were carried out in June 2008. Japanese adults (n = 245) aged 80 years were classified into quartiles based on periodontal inflamed surface area (PISA), which quantifies the degree of periodontal inflammation. Medical care use and costs were monitored by assessment of the National Health Insurance claim files from the baseline survey through the end of February 2011. Multivariable analysis of the differences in medical expenditure among PISA quartiles was carried out using linear regression with robust standard errors. RESULTS: The participants in the fourth (with the largest PISA) and third quartiles had significantly higher inpatient medical expenditure compared with those of the first quartile (P < 0.01 and = 0.04, respectively). Participants in the fourth quartile had significantly higher total medical expenditure (P < 0.01) compared with the first quartile. A trend was observed of higher inpatient and total medical expenditure with increasing PISA. CONCLUSIONS: A significant association was found between periodontitis and future increase in medical expenditure, suggesting that periodontitis might be a modifiable factor for the reduction of excess medical expenditure among elderly Japanese. Geriatr Gerontol Int 2016; 16: 856-864.
• Association between Dietary Intake and Bone Mineral Density in Japanese Postmenopausal Women: The Yokogoshi Cohort Study.
  Harumi Hirata; Kaori Kitamura; Toshiko Saito; Ryosaku Kobayashi; Masanori Iwasaki; Akihiro Yoshihara; Yumi Watanabe; Rieko Oshiki; Tomoko Nishiwaki; Kazutoshi Nakamura
  The Tohoku journal of experimental medicine, 239, 2, 95, 101, Jun. 2016, [Peer-reviewed], [Domestic magazines]
  English, Diet and food intake play an important role in the development of osteoporosis. However, apart from calcium and vitamin D, how nutrients affect bone status is not fully understood. The purpose of this study was to determine cross-sectional and longitudinal associations between dietary intake and bone mineral density (BMD) in Japanese postmenopausal women. This 5-year cohort study included 600 community-dwelling women aged 55-74 years at baseline in 2005. Information on demographics, nutrition, and lifestyle was obtained through interviews, and nutritional and dietary intake was assessed using a validated food frequency questionnaire. BMD measurements were performed by dual energy X-ray absorptiometry. In 2010, 498 women underwent follow-up BMD examinations. Multiple linear regression analysis was performed to determine associations of predictor variables with BMD, adjusting for confounders. In cross-sectional analyses, coffee or black tea consumption was positively associated with lumbar spine (P = 0.004) and total hip (P = 0.003) BMD, and alcohol intake was positively associated with femoral neck (P = 0.005) and total hip (P = 0.001) BMD. In longitudinal analyses, vitamin K (P = 0.028) and natto (fermented soybeans) (P = 0.023) were positively associated with lumbar spine BMD, and meat or meat product consumption was inversely associated with total hip (P = 0.047) BMD. In conclusion, dietary factors other than calcium and vitamin D intake are predictors of bone mass and bone loss in Japanese postmenopausal women. In particular, natto intake is recommended for preventing postmenopausal bone loss on the basis of current evidence.
• Serum antibody to Porphyromonas gingivalis in metabolic syndrome among an older Japanese population
  Masanori Iwasaki; Kumiko Minagawa; Misuzu Sato; Noboru Kaneko; Susumu Imai; Akihiro Yoshihara; Hideo Miyazaki
  GERODONTOLOGY, 33, 2, 193, 200, Jun. 2016, [Peer-reviewed]
  English, Scientific journal
• A century of trends in adult human height
  NCD Risk Factor Collaboration; NCD-RisC
  eLIFE, e13410, May 2016, [Peer-reviewed]
• Hyposalivation and dietary nutrient intake among community-based older Japanese
  Masanori Iwasaki; Akihiro Yoshihara; Kayoko Ito; Misuzu Sato; Kumiko Minagawa; Kanako Muramatsu; Reiko Watanabe; Michael C. Manz; Toshihiro Ansai; Hideo Miyazaki
  GERIATRICS & GERONTOLOGY INTERNATIONAL, 16, 4, 500, 507, Apr. 2016, [Peer-reviewed]
  English, Scientific journal
• Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants
  NCD Risk Factor Collaboration; NCD-RisC
  LANCET, 387, 10026, 1377, 1396, Apr. 2016, [Peer-reviewed]
  English, Scientific journal
• Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants
  NCD Risk Factor Collaboration; NCD-RisC
  LANCET, 387, 10027, 1513, 1530, Apr. 2016, [Peer-reviewed]
  English, Scientific journal
• PPARγ gene polymorphism, C-reactive protein level, BMI and periodontitis in post-menopausal Japanese women.
  Yangming Wang; Noriko Sugita; Akihiro Yoshihara; Masanori Iwasaki; Hideo Miyazaki; Kazutoshi Nakamura; Hiromasa Yoshie
  Gerodontology, 33, 1, 44, 51, Mar. 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Several studies have reported inconsistent results regarding the association between the PPARγPro12Ala polymorphism and obesity. Obese individuals had higher C-reactive protein (CRP) levels compared with those of normal weight, and PPARγ activation could significantly reduce serum high-sensitive CRP level. We have previously suggested that the Pro12Ala polymorphism represents a susceptibility factor for periodontitis, which is a known risk factor for increased CRP level. OBJECTIVES: The aim was to investigate associations between PPARγ gene polymorphism, serum CRP level, BMI and/or periodontitis among post-menopausal Japanese women. MATERIALS AND METHODS: The final sample in this study comprised 359 post-menopausal Japanese women. Periodontal parameters, including PD, CAL and BOP, were measured per tooth. PPARγPro12Ala genotype was determined by PCR-RFLP. Hs-CRP value was measured by a latex nephelometry assay. RESULTS: No significant differences in age, BMI or periodontal parameters were found between the genotypes. The percentages of sites with PD ≥ 4 mm were significantly higher among the hsCRP ≥ 1 mg/l group than the hsCRP < 1 mg/l group (p = 0.003). Positive correlations were found between serum hsCRP levels and the percentages of sites with PD ≥ 4 mm (p = 0.043) in PPARγ Ala allele carriers, and BMI (p = 0.033) in non-carriers. After adjustment for model covariates, BMI was significantly associated with serum hsCRP level. CONCLUSION: The PPARγPro12Ala polymorphism was not independently associated with periodontitis, serum CRP level or BMI in post-menopausal Japanese women. However, serum hsCRP level correlated with periodontitis in Ala allele carriers, and with BMI in non-carriers.
• Effects of Periodontal Diseases on Diabetes-Related Medical Expenditure
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Hideo Miyazaki
  Current Oral Health Reports, 3, 1, 7, 13, 2016, [Peer-reviewed], [Invited], [Lead author]
• Oral health status in relation to cognitive function among older Japanese.
  Masanori Iwasaki; Yumi Kimura; Akihiro Yoshihara; Hiroshi Ogawa; Takayuki Yamaga; Misuzu Sato; Taizo Wada; Ryota Sakamoto; Yasuko Ishimoto; Eriko Fukutomi; Wenling Chen; Hissei Imai; Michiko Fujisawa; Kiyohito Okumiya; George W Taylor; Toshihiro Ansai; Hideo Miyazaki; Kozo Matsubayashi
  Clinical and experimental dental research, 1, 1, 3, 9, Oct. 2015, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Epidemiologic data examining the relationship between oral health status and cognitive status are sparse, especially in Asian populations. This study aimed to assess whether periodontal disease and tooth loss were related to cognitive impairment among older Japanese. Study participants were 291 Japanese (101 men and 190 women, average age: 80.9 years), classified into three groups based on a clinical examination of oral health status: no periodontal disease, periodontal disease, and edentulous. Periodontal disease was defined using criteria recommended in the consensus report of the European Workshop in Periodontology with a modification. Cognitive impairment was defined using the results of the Mini-mental State Examination (MMSE) and Hasegawa Dementia Scale-Revised (HDS-R) scores. Multivariable logistic regression analyses assessed the relationship of the three-category oral health status variable (reference category = no periodontal disease) with low MMSE score (≤23) and low HDS-R score (≤20). Age, gender, years of education, body mass index, smoking status, drinking behavior, and history of cardiovascular disease were tested as potential confounders in the multivariable models. Periodontal disease and edentulous were significantly associated with greater odds of low cognitive performance after controlling for potential confounders. The multivariable adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for low MMSE score associated with periodontal disease and edentulous were 2.21 (1.01-4.84) and 2.28 (1.06-4.90), respectively. The multivariable adjusted ORs (95% CIs) for low HDS-R score associated with periodontal disease and edentulous were 4.85 (1.29-18.15) and 3.86 (1.05-14.20), respectively. Poor oral health status was significantly associated with cognitive impairment among community-dwelling older Japanese. Additional well-controlled longitudinal studies are needed to elucidate whether there may be a possible cause-and-effect relationship between oral health status and cognitive function.
• The Interaction Between β-3 Adrenergic Receptor and Peroxisome Proliferator-Activated Receptor Gamma Gene Polymorphism to Periodontal Disease in Community-Dwelling Elderly Japanese.
  Akihiro Yoshihara; Noriko Sugita; Masanori Iwasaki; Yanming Wang; Hideo Miyazaki; Hiromasa Yoshie; Kazutoshi Nakamura
  Journal of periodontology, 86, 8, 955, 63, Aug. 2015, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: It has been hypothesized that β-3 adrenergic receptor and peroxisome proliferator-activated receptor gamma (PPARγ) might have gene-environmental and gene-gene interactions in periodontal disease. The purpose of this study is to elucidate the interaction between β-3 adrenergic receptor and PPARγ gene polymorphism with periodontal disease. METHODS: Three hundred thirty-two postmenopausal females were enrolled, and their serum high-sensitivity C-reactive protein (hsCRP) and hemoglobin A1c (HbA1c) were examined. β-3 adrenergic receptor and PPARγ genotypes were then determined. An oral examination was performed. The number of remaining teeth was counted, and the probing depth (PD) and clinical attachment level (CAL) were measured. Prevalence-rate ratios (PRRs) were calculated by multiple Poisson regression analyses to evaluate the relationship among periodontal disease markers, such as the number of sites with CAL 4 to 5 or ≥6 mm or PD 4 to 5 or ≥6 mm, and β-3 adrenergic receptor polymorphisms, PPARγ polymorphisms, and the interaction term adjusted by age, hsCRP, and HbA1c, after converting the number of remaining teeth (n) to an offset variable. RESULTS: In the participants with body mass index (BMI) ≥25, PRRs of β-3 adrenergic receptor genotype (Trp/Arg and Arg/Arg) for periodontal disease markers were 0.13 to 0.70 (P <0.0001 to 0.74), those of PPARγ genotype (Pro/Pro) were 0.66 to 3.14 (P = 0.01 to 0.68), and those of the interaction term for the two genotypes were 1.69 to 12.61 (P <0.0001 to 0.33). However, in the participants with BMI <25, a constant tendency was not observed. CONCLUSION: The results confirmed a positive relationship between the interaction term for β-3 adrenergic receptor genotype and PPARγ genotype and various periodontal markers in obese elderly females.
• Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331288 participants
  NCD Risk Factor Collaboration; NCD-RisC
  LANCET DIABETES & ENDOCRINOLOGY, 3, 8, 624, 637, Aug. 2015, [Peer-reviewed]
  English, Scientific journal
• Association between dental status and food diversity among older Japanese
  Iwasaki M; Y. Kimura; A. Yoshihara; H. Ogawa; T. Yamaga; T. Takiguchi; T. Wada; R. Sakamoto; Y. Ishimoto; E. Fukutomi; W. Chen; H. Imai; M. Fujisawa; K. Okumiya; M. C. Manz; H. Miyazaki; K. Matsubayashi
  COMMUNITY DENTAL HEALTH, 32, 2, 104, 110, Jun. 2015, [Peer-reviewed]
  English, Scientific journal
• Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women
  Y. Hanai; N. Sugita; Y. Wang; A. Yoshihara; Iwasaki M; H. Miyazaki; K. Nakamura; H. Yoshie
  ARCHIVES OF ORAL BIOLOGY, 60, 4, 533, 539, Apr. 2015, [Peer-reviewed]
  English, Scientific journal
• 地域在住高齢者における歯・口腔の健康が認知機能検査スコアに与える影響
  岩崎 正則; 葭原 明弘; 小川 祐司; 山賀 孝之; 佐藤 美寿々; 安細 敏弘; 宮崎 秀夫
  口腔衛生学会雑誌, 65, 2, 195, 195, (一社)日本口腔衛生学会, Apr. 2015, [Peer-reviewed]
  Japanese
• Relationship between metabolic syndrome and periodontitis in 80-year-old Japanese subjects.
  K Minagawa; Iwasaki M; H Ogawa; A Yoshihara; H Miyazaki
  Journal of periodontal research, 50, 2, 173, 9, Apr. 2015, [Peer-reviewed], [International Magazine]
  English, BACKGROUND AND OBJECTIVE: Potentially significant associations between metabolic syndrome (MetS) and periodontitis have been reported in recent studies; however, there are limited data on their association in the very old. The aim of this cross-sectional study was to investigate the association between MetS and periodontitis among 80-year-old Japanese subjects. MATERIAL AND METHODS: The subjects were 234 Japanese aged 80 years old who participated in a health and periodontal examination in June 2008 in Niigata city, Japan, and were classified into three groups: (i) severe periodontitis: having six or more interproximal sites with clinical attachment level ≥ 6 mm and three or more interproximal sites with probing pocket depth (PPD) ≥ 5 mm (not on the same tooth) (n = 19); (ii) moderate periodontitis: having six or more interproximal sites with clinical attachment level ≥ 4 mm or six or more interproximal sites with PPD ≥ 5 mm (not on the same tooth) (n = 162); and (iii) no or mild periodontitis: neither "moderate" nor "severe" periodontitis (n = 53). MetS was defined using the modified criteria of the guidelines for the diagnosis of MetS in Japan. An ordinal logistic regression model was used to evaluate the association between MetS and periodontitis. Adjustments for gender, income, education, smoking status, dental visiting patterns, brushing frequency, exercise habits and dietary energy and food intake were considered. RESULTS: Overall, 57 individuals (24.4%) were diagnosed as having MetS. MetS was associated with the presence and severity of periodontitis (crude odds ratio = 2.24, 95% confidence interval = 1.14-4.41). This association remained statistically significant after multivariate adjustments (adjusted odds ratio = 2.10, 95% confidence interval = 1.03-4.28). CONCLUSION: Our findings provide evidence of an association between MetS and periodontitis in elderly Japanese.
• Longitudinal Relationship Between Metabolic Syndrome and Periodontal Disease Among Japanese Adults Aged >= 70 Years: The Niigata Study
  Masanori Iwasaki; Misuzu Sato; Kumiko Minagawa; Michael C. Manz; Akihiro Yoshihara; Hideo Miyazaki
  JOURNAL OF PERIODONTOLOGY, 86, 4, 491, 498, Apr. 2015, [Peer-reviewed]
  English, Scientific journal
• Low dietary diversity among older Japanese adults with impaired dentition
  Iwasaki M; Kimura Y; Yoshihara A; Ogawa H; Yamaga T; Wada T; Sakamoto R; Ishimoto Y; Fukutomi E; Chen W; Imai H; Fujisawa M; Okumiya K; Manz MC; Ansai T; Miyazaki H; Matsubayashi K
  Journal of Dentistry and Oral Hygiene, 7, 4, 71, 77, 2015, [Peer-reviewed]
• Oral health status: relationship to nutrient and food intake among 80-year-old Japanese adults
  Masanori Iwasaki; George W. Taylor; Michael C. Manz; Akihiro Yoshihara; Misuzu Sato; Kanako Muramatsu; Reiko Watanabe; Hideo Miyazaki
  COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY, 42, 5, 441, 450, Oct. 2014, [Peer-reviewed]
  English, Scientific journal
• Association between low renal function and tooth loss over 5 years.
  Akihiro Yoshihara; Masanori Iwasaki; Hideo Miyazaki; Kazutoshi Nakamura
  Gerodontology, 31, 2, 111, 6, Jun. 2014, [Peer-reviewed], [International Magazine]
  English, OBJECTIVES: This longitudinal study evaluated the relationship between low renal function and tooth loss in elderly subjects. MATERIAL AND METHODS: Subjects comprised 406 female subjects (55-74 years old) who agreed to participate in a baseline examination and a follow-up examination after 5 years. Serum cystatin C levels were used to assess renal function. Multiple logistic regression analysis was used to evaluate the relationship between tooth loss and change in serum cystatin C levels over 5 years. Tooth loss over 5 years (0: no, 1: yes) was used as the dependent variable. Seven variables were used as independent variables, including change in serum cystatin C levels over 5 years. RESULTS: Results of multiple logistic regression analysis showed that cystatin C change over 5 years, age, number of remaining teeth at baseline, number of sites with ≥4 mm clinical attachment level at baseline and serum 25-hydroxyvitamin D levels at baseline were significantly associated with tooth loss. The odds ratio for tooth loss with cystatin C change over 5 years was 7.70 (p=0.029). CONCLUSION: This study indicates a relationship between serum cystatin C levels and number of missing teeth, and thus suggests that low renal function is associated with tooth loss.
• The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese.
  Akihiro Yoshihara; Noriko Sugita; Masanori Iwasaki; Hideo Miyazaki; Kazutoshi Nakamura
  Journal of clinical periodontology, 41, 5, 460, 6, May 2014, [Peer-reviewed], [International Magazine]
  English, Scientific journal, OBJECTIVES: The purpose of this study was to elucidate whether the association between beta-3 adrenergic receptor polymorphism and periodontal disease is modified by body weight. MATERIAL AND METHODS: We enrolled 332 postmenopausal women and determined their HbA1C levels (%) and beta-3 adrenergic receptor (rs4994) genotypes. Periodontal parameters including clinical attachment level (CAL) were measured. After selecting subjects for each body mass index (BMI) level, the prevalence rate ratio (PRR) by multiple Poisson regression analysis was calculated to evaluate the relationship between periodontal disease and beta-3 adrenergic receptor polymorphism. The number of sites with CAL≥6 mm was used as a dependent variable, and beta-3 adrenergic receptor genotype [categorized as Arg non-carriers (reference) or Arg carriers], age (y) and HbA1C (%) were adopted as independent variables. We converted the number of probing sites (n) to an offset variable. RESULTS: The PRR of the beta-3 adrenergic receptor genotype for the number of sites of CAL≥6 mm showed a positive association in subjects with BMI≥25.0 and increased markedly with BMI. The PRR in subjects with BMI≥30 was 3.10 (p < 0.0001). CONCLUSION: This study indicates a positive association between periodontal disease and the beta-3 adrenergic receptor genotype in obese individuals.
• Association between low bone mineral density and clinical attachment loss in Japanese postmenopausal females
  Masanori Iwasaki; George W. Taylor; Kazutoshi Nakamura; Akihiro Yoshihara; Hideo Miyazaki
  Journal of Periodontology, 84, 12, 1708, 1716, Dec. 2013, [Peer-reviewed]
  English, Scientific journal
• Serum albumin levels and 10-year tooth loss in a 70-year-old population
  A. Yoshihara; Iwasaki M; H. Ogawa; H. Miyazaki
  JOURNAL OF ORAL REHABILITATION, 40, 9, 678, 685, Sep. 2013, [Peer-reviewed]
  English, Scientific journal
• Dietary antioxidants and periodontal disease in community-based older Japanese: a 2-year follow-up study
  Masanori Iwasaki; Paula Moynihan; Michael C. Manz; George W. Taylor; Akihiro Yoshihara; Kanako Muramatsu; Reiko Watanabe; Hideo Miyazaki
  PUBLIC HEALTH NUTRITION, 16, 2, 330, 338, Feb. 2013, [Peer-reviewed]
  English, Scientific journal
• Peroxisome proliferator-activated receptor (PPAR) γ polymorphism, vitamin d, bone mineral density and periodontitis in postmenopausal women
  Y. Wang; N. Sugita; A. Yoshihara; M. Iwasaki; H. Miyazaki; K. Nakamura; H. Yoshie
  Oral Diseases, 19, 5, 501, 506, 2013, [Peer-reviewed]
  English, Scientific journal
• High serum 25-hydroxyvitamin D levels do not retard postmenopausal bone loss in Japanese women: the Yokogoshi study.
  Kaori Kitamura; Kazutoshi Nakamura; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Tomoko Nishiwaki; Masanori Iwasaki; Akihiro Yoshihara
  Archives of osteoporosis, 8, 153, 153, 2013, [Peer-reviewed], [International Magazine]
  English, UNLABELLED: We conducted a cohort study exploring an association between serum 25-hydroxyvitamin D (serum 25(OH)D) and parathyroid hormone (PTH) levels and 5-year changes in bone mineral density (BMD) in 482 postmenopausal women. High serum 25(OH)D levels do not retard postmenopausal bone loss within the lumbar spine or femoral neck, and high PTH levels potentially increase hip bone loss. PURPOSE: The aim of this study was to explore an association between serum 25(OH)D levels and 5-year changes in BMD in postmenopausal women. METHODS: This 5-year cohort study included 482 women between 55 and 74 years of age who lived in a community in Japan. Medical examinations were conducted in 2005 and 2010. Data were obtained on baseline serum 25(OH)D and intact parathyroid hormone (iPTH) levels. Outcomes of this study were 5-year changes in BMDs of the lumbar spine and femoral neck. Covariates included years since menopause, body mass index (BMI), lifestyle factors, and weight change. Changes in BMDs among quartiles of serum 25(OH)D were compared with analysis of covariance. RESULTS: The mean age of subjects was 63.1 years, and mean serum 25(OH)D levels were 56.0 nmol/L. Age and decrease in weight were significantly associated with decreases in BMDs of both the lumbar spine (P for trend < 0.001 and =0.002, respectively) and femoral neck (P for trend = 0.026 and <0.001, respectively); low BMI was associated with a decrease in lumbar spine BMD (P for trend < 0.001). No significant associations were found between serum 25(OH)D levels and changes in BMDs. High serum iPTH levels were associated with a greater decrease in femoral neck BMD (P for trend = 0.026). CONCLUSIONS: High serum 25(OH)D levels do not retard postmenopausal bone loss within the lumbar spine or femoral neck, and high PTH levels potentially increase hip bone loss.
• Serum Antibody to Porphyromonas gingivalis in Chronic Kidney Disease
  Iwasaki M; G. W. Taylor; M. C. Manz; N. Kaneko; S. Imai; A. Yoshihara; H. Miyazaki
  JOURNAL OF DENTAL RESEARCH, 91, 9, 828, 833, Sep. 2012, [Peer-reviewed]
  English, Scientific journal
• Change in bone mineral density and tooth loss in Japanese community-dwelling postmenopausal women: a 5-year cohort study
  Masanori Iwasaki; Kazutoshi Nakamura; Akihiro Yoshihara; Hideo Miyazaki
  JOURNAL OF BONE AND MINERAL METABOLISM, 30, 4, 447, 453, Jul. 2012, [Peer-reviewed]
  English, Scientific journal
• 地域在住高齢者におけるメタボリックシンドロームと歯周病の関連
  坂入 久美子; 岩崎 正則; 小川 祐司; 葭原 明弘; 宮崎 秀夫
  新潟歯学会雑誌, 42, 1, 63, 64, 新潟歯学会, Jun. 2012
  Japanese
• 地域在住高齢者におけるメタボリックシンドロームと歯周病の関連
  坂入 久美子; 岩崎 正則; 小川 祐司; 葭原 明弘; 宮崎 秀夫
  口腔衛生学会雑誌, 62, 2, 217, 217, (一社)日本口腔衛生学会, Apr. 2012
  Japanese
• Relations of Serum Ascorbic Acid and alpha-tocopherol to Periodontal Disease
  M. Iwasaki; M. C. Manz; G. W. Taylor; A. Yoshihara; H. Miyazaki
  JOURNAL OF DENTAL RESEARCH, 91, 2, 167, 172, Feb. 2012, [Peer-reviewed]
  English, Scientific journal
• Periodontal Disease and Decreased Kidney Function in Japanese Elderly
  Masanori Iwasaki; George W. Taylor; Willem Nesse; Arjan Vissink; Akihiro Yoshihara; Hideo Miyazaki
  AMERICAN JOURNAL OF KIDNEY DISEASES, 59, 2, 202, 209, Feb. 2012, [Peer-reviewed]
  English, Scientific journal
• 地域在住女性高齢者における咀嚼能力判定試験と開眼片足立ち保持時間の関連
  岩崎正則; 葭原明弘; 宮崎秀夫
  日本口腔衛生学会雑誌, 62, 289, 295, 2012, [Peer-reviewed], [Lead author]
  Japanese, Scientific journal
• Mineral content of calcium and magnesium in the serum and longitudinal periodontal progression in Japanese elderly smokers.
  Akihiro Yoshihara; Masanori Iwasaki; Hideo Miyazaki
  Journal of clinical periodontology, 38, 11, 992, 7, Nov. 2011, [Peer-reviewed], [International Magazine]
  English, OBJECTIVE: Evidence from physiological and clinical studies regarding the mechanism by which calcium and magnesium are associated with periodontal disease, adjusted for smoking habits, is lacking. This longitudinal study evaluated the association of serum calcium levels and the calcium/magnesium (Ca/Mg) ratio with periodontal disease progression among smokers and non-smokers. MATERIAL AND METHODS: A total of 309 subjects aged 73 years were included. Follow-up surveys were carried out every year for 6 years. After dividing subjects into smokers and non-smokers, multiple logistic regression analysis for men was performed to evaluate the relationship between the serum Ca/Mg ratio and periodontal disease progression. We used the 25th percentile of periodontal disease events for 6 years as the dependent variable and seven other variables, including quartiles for serum Ca/Mg ratios, as independent variables. RESULTS: There was a clear dose-response relationship of Ca/Mg ratio quartiles for periodontal disease events among smokers. Significant differences in odds ratios in the first and second quartiles were seen compared with the fourth quartile (reference): 6.28 (p=0.014) and 5.96 (p=0.022), respectively. However, there was no significant dose-response relationship among non-smokers. CONCLUSION: A low serum Ca/Mg ratio was significantly associated with periodontal disease progression in Japanese elderly smokers.
• 特定健診対象者における歯周疾患スクリーニングテストとメタボリックシンドロームとの関連性
  岩崎 正則; 葭原 明弘; 宮崎 秀夫
  口腔衛生学会雑誌, 61, 5, 573, 580, (一社)日本口腔衛生学会, Oct. 2011
  Japanese
• 成人期および高齢期における咀嚼回数と体格の関連
  岩崎 正則; 葭原 明弘; 宮崎 秀夫
  口腔衛生学会雑誌, 61, 5, 563, 572, (一社)日本口腔衛生学会, Oct. 2011
  Japanese
• Physical activity and 5-year changes in physical performance tests and bone mineral density in postmenopausal women: the Yokogoshi Study.
  Kaori Kitamura; Kazutoshi Nakamura; Ryosaku Kobayashi; Rieko Oshiki; Toshiko Saito; Mari Oyama; Shunsuke Takahashi; Tomoko Nishiwaki; Masanori Iwasaki; Akihiro Yoshihara
  Maturitas, 70, 1, 80, 4, Sep. 2011, [Peer-reviewed], [International Magazine]
  English, OBJECTIVE: The effect of physical activity on musculoskeletal health in older adults is not completely understood. The aim of this study was to determine the relationship between physical activity and 5-year changes in physical performance tests and bone mineral density (BMD) in postmenopausal women. STUDY DESIGN: The design was a 5-year cohort study. MAIN OUTCOME MEASURES: Subjects were 507 women (55-74 years old) living in a rural community in Japan. Physical activity assessed included housework, farm work, and moderate leisure-time physical activity within the previous week. Measurements at baseline included handgrip strength, walking time (timed "Up & Go" test) and BMD of the femoral neck and vertebrae. Five-year changes in these measures (outcome variables) were compared among groups with different levels of physical activity by analysis of covariance. RESULTS: Women who did not do housework performed worse in changes in handgrip strength (difference=2.22 kg, P=0.0201) and worse in changes in the walking time (difference=0.54 s, P=0.0072) than those who did housework alone. Women who spent at least 9h per week (median=24) doing farm work performed better in changes in handgrip strength (difference=0.28 kg, P=0.0334), but worse in changes in the walking time (difference=0.66 s, P<0.0001) than those who did not do farm work. However, leisure-time activity was not associated with changes in any outcome variable, and none of the physical activities predicted BMD changes. CONCLUSIONS: Engaging in housework and farm work are determinants of physical function in postmenopausal women, which may help them maintain independence in daily living.
• Dietary ratio of n-6 to n-3 polyunsaturated fatty acids and periodontal disease in community-based older Japanese: A 3-year follow-up study
  Masanori Iwasaki; George W. Taylor; Paula Moynihan; Akihiro Yoshihara; Kanako Muramatsu; Reiko Watanabe; Hideo Miyazaki
  PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 85, 2, 107, 112, Aug. 2011, [Peer-reviewed]
  English, Scientific journal
• Relationship between Saturated Fatty Acids and Periodontal Disease
  Iwasaki M; M. C. Manz; P. Moynihan; A. Yoshihara; K. Muramatsu; R. Watanabe; H. Miyazaki
  JOURNAL OF DENTAL RESEARCH, 90, 7, 861, 867, Jul. 2011, [Peer-reviewed]
  English, Scientific journal
• Dietary omega-3 fatty acid may control periodontal disease Low dietary docosahexaenoic acid might be a significant risk factor of periodontal disease progression
  Masanori Iwasaki; Akihiro Yoshihara; Paula Moynihan; Reiko Watanabe; Hideo Miyazaki
  AGRO FOOD INDUSTRY HI-TECH, 21, 6, 34, 37, Nov. 2010, [Peer-reviewed]
  English, Scientific journal
• Longitudinal relationship between dietary omega-3 fatty acids and periodontal disease
  Masanori Iwasaki; Akihiro Yoshihara; Paula Moynihan; Reiko Watanabe; George W. Taylor; Hideo Miyazaki
  NUTRITION, 26, 11-12, 1105, 1109, Nov. 2010, [Peer-reviewed]
  English, Scientific journal
• 飽和脂肪酸が歯周病の発症・進行に与える影響
  岩崎 正則; 葭原 明弘; 村松 芳多子; 渡邊 令子; 宮崎 秀夫
  口腔衛生学会雑誌, 60, 4, 388, 388, (一社)日本口腔衛生学会, Aug. 2010
  Japanese
• 高齢者における咀嚼回数と食品群別摂取量および栄養素等摂取量との関連
  岩崎 正則; 葭原 明弘; 村松 芳多子; 渡邊 令子; 宮崎 秀夫
  口腔衛生学会雑誌, 60, 2, 128, 138, (一社)日本口腔衛生学会, Apr. 2010
  Japanese
• The Relationship between the Speed of Eating and Nutritional Intake of Japanese Aged 80 Years Old Based on Responses to a Brief-type Self-administered Diet History Questionnaire
  IWASAKI Masanori; YOSHIHARA Akihiro; MURAMATSU Kanako; WATANABE Reiko; MIYAZAKI Hideo
  Journal of dental health, 60, 1, 30, 37, The Japanese Society for Dental Health, 2010, [Peer-reviewed]
  Japanese, Scientific journal, A brief-type self-administered diet history questionnaire (BDHQ) is a validated method of dietary assessment. This study investigated the relationship between the speed of eating, which is considered an eating behavior, and the estimated nutrient intake using the BDHQ in community-dwelling Japanese aged 80 years old. Three hundred and fifty-four participants (174 males and 180 females) aged 80 years old who participated in both dental examinations and BDHQ assessment conducted in 2008 were included in the analysis. The speed of eating was self-reported by giving a response chosen from five qualitative categories: 'very fast', 'relatively fast', 'medium', 'relatively slowly', and 'very slowly'. The five categories were classified into two categories for statistical analysis, that is, participants who answered 'very fast' and 'relatively fast' were defined as 'eating fast', while those who answered 'medium', 'relatively slowly', and 'very slowly' were defined as 'eating slowly'. The nutrient intake was calculated from the BDHQ using the ad-hoc program developed for nutrient calculation based on BDHQ responses. The estimated nutrient intake was compared between the two groups defined as eating 'fast' or 'slowly'. Furthermore, multivariable linear regression analysis was conducted using the speed of eating, gender, BMI, number of teeth, and masticatory function as independent variables to assess the influence on the estimated nutrient intake. The participants defined as eating 'fast' consumed significantly more zinc, copper, cryptoxanthin, and vitamin C than participants defined as eating 'slowly' (p=0.012, p=0.022, p=0.007, and p=0.049, respectively; Student's t-test). Moreover, the zinc, copper, cryptoxanthin, and vitamin C intakes of participants defined as eating 'fast' remained significantly higher than those of participants defined as eating 'slowly' after simultaneously adjusting for possible confounders (p=0.027, p=0.039, p=0.004, and p=0.043, respectively). The findings of this study suggest that Japanese people aged 80 years old who define themselves as eating fast consume higher levels of nutrients that are included in meat, fish, shellfish, vegetables, and fruits.
• Longitudinal study on the relationship between serum albumin and periodontal disease
  Masanori Iwasaki; Akihiro Yoshihara; Toshinobu Hirotomi; Hiroshi Ogawa; Nobuhiro Hanada; Hideo Miyazaki
  JOURNAL OF CLINICAL PERIODONTOLOGY, 35, 4, 291, 296, Apr. 2008, [Peer-reviewed]
  English, Scientific journal

• Measuring the Invisible: Microbial Diagnostics for Periodontitis-A Narrative Review
  Michihiko Usui; Suzuka Miyagi; Rieko Yamanaka; Yuichiro Oka; Kaoru Kobayashi; Tsuyoshi Sato; Kotaro Sano; Satoru Onizuka; Maki Inoue; Wataru Fujii; Masanori Iwasaki; Wataru Ariyoshi; Keisuke Nakashima; Tatsuji Nishihara, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26, 20, 19 Oct. 2025
  English, Book review
• 幼少期の逆境体験とポジティブな経験がその後の歯痛に与える影響:横断研究
  山本貴文; 佐藤美寿々; 岩崎正則, 口腔衛生学会雑誌, 75, 2025
• 食事摂取におけるNa/K比と現在歯数との関連(魚沼コホート研究)第二報:調味料・食品との関連
  諏訪間加奈; 岩崎正則; 伊藤由美; 中村夢衣; 柴田佐都子; 竹原祥子; 葭原明弘, 口腔衛生学会雑誌, 75, 2025
• 食事摂取におけるナトリウム/カリウム(Na/K)比と現在歯数との関連(魚沼コホート研究)第一報
  中村夢衣; 岩崎正則; 伊藤由美; 諏訪間加奈; 柴田佐都子; 竹原祥子; 葭原明弘, 口腔衛生学会雑誌, 75, 2025
• 腎機能と自己申告による現在歯数との関連(魚沼コホート調査ベースラインデータより)—Relationship between Renal Function and Self-reported Number of Current Teeth (From the Uonuma Cohort Study Baseline Data)
  皆川 久美子; 葭原 明弘; 宮本 茜; 諏訪間 加奈; 岩崎 正則; 竹原 祥子; 小川 祐司, 口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health / 日本口腔衛生学会 編, 74, 2, 125, 134, Apr. 2024
  東京 : 日本口腔衛生学会, Japanese
• 後期高齢者における主観的口腔機能低下・歯科受診状況と低栄養・身体的フレイルの関連
  佐藤美寿々; 岩崎正則; 渡邊裕; 石丸美穂; 大野幸子; 飯島勝矢; 遠又靖丈; 田中和美; 津下一代, 日本公衆衛生学会総会抄録集(CD-ROM), 83rd, 2024
• 複数のタバコ製品使用は歯痛と関連するか:横断研究
  山本貴文; 佐藤美寿々; 岩崎正則; 田淵貴大, 日本公衆衛生学会総会抄録集(CD-ROM), 83rd, 2024
• 地域在住高齢者における定期歯科受診状況とオーラルフレイル(OF-5)の関連性の検討:お達者健診研究
  松原ちあき; 松原ちあき; 白部麻樹; 本川佳子; 枝広あや子; 五味達之祐; 岩崎正則; 岩崎正則; 大渕修一; 平野浩彦, 日本老年歯科医学会学術大会(Web), 35th, 2024
• 糖尿病をもつ人の歯科受療行為と糖尿病診療ガイドライン改定の影響-ビッグデータを活用した実態把握及び時系列分析
  佐藤美寿々; 佐藤美寿々; 石丸美穂; 大野幸子; 岩崎正則; 康永秀生, 8020公募研究報告書抄録(Web), 2023, 2023
• 日本人中年期男女における睡眠時間と歯周病の関連
  岩崎 正則; 臼井 通彦; 有吉 渉; 中島 啓介; 吉岡 香絵; 井上 真紀; 小林 薫; 西原 達次, Journal of Epidemiology, 32, Suppl.1, 168, 168, Jan. 2022
  (一社)日本疫学会, Japanese
• Associations Between Periodontal Health/Treatment and Cognitive Impairment: Latest Evidence From Epidemiological Studies
  Misuzu Sato; Masanori Iwasaki; Kumiko Minagawa; Akane Miyamoto, Current Oral Health Reports, 7, 2, 119, 128, Jun. 2020
  Book review
• 農村地域における高齢者の食行動と健康度との関連
  木村 友美; 坂本 龍太; 和田 泰三; 藤澤 道子; 奥宮 清人; 石本 恭子; 加藤 恵美子; 竜野 真維; 岩崎 正則; 松林 公蔵, 日本老年医学会雑誌, 56, Suppl., 109, 109, May 2019
  (一社)日本老年医学会, Japanese
• 75歳以上地域在住高齢者におけるフレイルとADL、転倒、うつ傾向、QOLとの関連
  笠原 順子; 木村 友美; 石本 恭子; 岩崎 正則; 坂本 龍太; 松林 公蔵, 日本老年医学会雑誌, 55, Suppl., 151, 152, May 2018
  (一社)日本老年医学会, Japanese
• アジア地域に暮らす高齢者のフレイル 日本とタイにおける混合研究法を用いた考察
  木村 友美; 石本 恭子; 岩崎 正則; 笠原 順子; 和田 泰三; 藤澤 道子; 坂本 龍太; 奥宮 清人; 松林 公蔵, 日本老年医学会雑誌, 55, Suppl., 108, 108, May 2018
  (一社)日本老年医学会, Japanese
• 委員会報告 平成28年歯科疾患実態調査の解析作業報告および今後に向けた提言
  安藤 雄一; 岩﨑 正則; 竹内 倫子; 北村 雅保; 玉置 洋; 柳澤 智仁, 口腔衛生学会雑誌 = Journal of dental health : official publication of Japanese Society for Oral Health / 日本口腔衛生学会 編, 68, 2, 106, 113, Apr. 2018
  東京 : 日本口腔衛生学会, Japanese
• Effects of ritual tooth extraction on development of mandibular torus in Jomon people of Japan
  KATAOKA Shota; IWASAKI Masanori; TAKAHASHI Toru; TSURUTA Miho; KAKUTA Satoko; SOH Inho; ANSAI Toshihiro, Asian Journal of Paleopathology, 2, 2018
• 高齢者における口腔と栄養
  岩崎 正則; 小川 祐司; 木村 友美; 葭原 明弘; 宮崎 秀夫, ヘルスサイエンス・ヘルスケア, 17, 2, 46, 52, Dec. 2017
  深井保健科学研究所, Japanese
• 地域在住高齢者のフレイルと食事摂取状況との関連
  木村友美; 石本恭子; 岩崎正則; 笠原順子; 坂本龍太; 和田泰三; 奥宮清人; 藤澤道子; 松林公蔵, 日本老年医学会雑誌, 54, 162, 25 May 2017
  Japanese
• 地域在住高齢者におけるフレイルスコアと転倒スコアの関連
  石本 恭子; 木村 友美; 岩崎 正則; 和田 泰三; 笠原 順子; 坂本 龍太; 藤澤 道子; 奥宮 清人; 松林 公蔵, 日本老年医学会雑誌, 54, Suppl., 159, 160, May 2017
  (一社)日本老年医学会, Japanese
• 施設利用高齢者の食欲指標SNAQと栄養状態及び健康関連QOLとの関連性について
  山田志麻; 岩崎正則; 濱嵜朋子; 増田渉; 田川辰也; 角田聡子; 安細敏弘, 栄養学雑誌, 75, 5 Supplement, 2017
• 地域在住高齢者の食欲不振と栄養・口腔状況およびQOLとの関連
  木村友美; 岩崎正則; 奥宮清人; 和田泰三; 藤澤道子; 坂本龍太; 石本恭子; 大塚邦明; 宮崎秀夫; 松林公蔵, 日本老年医学会雑誌, 53, 88, 18 May 2016
  Japanese
• Effects of Periodontal Diseases on Diabetes-Related Medical Expenditure
  Masanori Iwasaki; Misuzu Sato; Akihiro Yoshihara; Hideo Miyazaki, Current Oral Health Reports, 3, 1, 7, 13, Mar. 2016
  Book review
• EBM : evidence-based medicine : Oral health and nutrition
  岩﨑 正則, 8020 : はち・まる・にい・まる : 財団法人8020推進財団会誌, 15, 32, 35, Jan. 2016
  8020推進財団, Japanese
• 在宅高齢者における簡易嚥下状態評価(EAT-10)と栄養状態および栄養素摂取との関連
  濱嵜朋子; 廣冨敏伸; 秋山理加; 岩崎正則; 邵仁浩; 粟野秀慈; 山田志麻; 巴美樹; 葭原明弘; 宮崎秀夫; 安細敏弘, 口腔衛生学会雑誌, 65, 2, 2015
• The relationship between oral health and medical expenditures among older adults
  岩﨑 正則; 葭原 明弘; 宮﨑 秀夫, 8020 : はち・まる・にい・まる : 財団法人8020推進財団会誌, 14, 112, 114, Jan. 2015
  8020推進財団, Japanese
• 高齢者における歯・口腔の健康と全身の健康の関連に関する医療費分析調査 (8020推進財団 指定研究事業報告)
  岩﨑 正則; 葭原 明弘; 宮﨑 秀夫, 8020 : はち・まる・にい・まる : 財団法人8020推進財団会誌, 13, 111, 113, Jan. 2014
  8020推進財団, Japanese
• O-10 地域在住女性高齢者における腎機能と歯周組織の炎症部位面積に関する横断調査(一般口演)
  岩崎 正則; 葭原 明弘; 宮崎 秀夫, 口腔衛生学会雑誌, 63, 2, 148, 148, 30 Apr. 2013
  有限責任中間法人日本口腔衛生学会, Japanese
• 高齢者における歯・口腔の健康と全身の健康の関連に関する医療費分析調査
  葭原 明弘; 岩崎 正則; 宮崎 秀夫, 8020: はち・まる・にい・まる, 12, 102, 103, Jan. 2013
  (公財)8020推進財団, Japanese
• 口腔の健康と全身の健康 : 新潟高齢者研究の結果から
  宮﨑 秀夫; 葭原 明弘; 岩崎 正則, 日本歯科衛生学会雑誌, 7, 1, 24, 34, Aug. 2012
  日本歯科衛生学会, Japanese
• Longitudinal study on the relationship between serum albumin and periodontal disease
  Iwasaki Masanori, 新潟歯学会雑誌, 41, 1, 39, 40, Jun. 2011
  新潟歯学会, Japanese
• 血清アルブミンと歯周病の関係についての経年的評価
  岩崎 正則; 葭原 明弘; 廣冨 敏伸; 小川 祐司; 花田 信弘; 宮崎 秀夫, 新潟歯学会雑誌, 38, 1, 46, 46, Jun. 2008
  新潟歯学会, Japanese

• Geriatric Medicine (老年医学) 60巻 6号
  4. オーラルフレイルと口腔機能低下症
  Mar. 2022, [Contributor]
• 新編衛生学・公衆衛生学
  安井利一; 尾﨑哲則; 埴岡隆; 森田学; 山下喜久; 岸光男; 嶋﨑義浩, 第2章 疫学
  Feb. 2021, [Contributor]
• 臨床栄養 臨時増刊号 特集 管理栄養士・栄養士が知っておきたい口腔のミニマムエッセンス オーラルフレイルの視点から
  歯・口腔の健康と栄養に関する最近の研究報告（文献レビュー）
  Sep. 2020, [Contributor]
• <平成28年>歯科疾患実態調査報告
  岩﨑 正則, 永久歯う蝕の状況および保有（喪失）状況（5歳以上）・補綴の状況・歯肉の状況・歯ブラシの使用状況・顎関節の自覚症状（6歳以上）・歯や口の状態および清掃状況
  May 2019, [Contributor]
• 健康長寿のための口腔保健と栄養をむすぶエビデンスブック
  深井, 穫博, 栄養摂取と口腔保健の関係; 食事の多様性と口腔保健
  医歯薬出版, 2019, 9784263445624, viii, 163p, [Contributor]
• 認知症の人への歯科治療ガイドライン
  日本老年歯科医学会; 日本医療研究開発機構研究費「認知症の容態に応じた歯科診療等の口腔管理及び栄養マネジメントによる経口摂取支援に関する研究」ガイドライン作成班, コンセンサスボードメンバー
  医歯薬出版, 2019, 9784263445563, xiii, 176p, Japanese, [Others]
• 文献ベースで歯科臨床の疑問に答えるチェアサイドQ&A 予防歯科編 PART1
  於保, 孝彦; 予防歯科臨床教育協議会, デンタルフロス「フロスを使うと歯にすきまができるのではないか」と言われた。
  クインテッセンス出版, Dec. 2018, 9784781206585, 119p, Japanese, [Contributor]
• 臨床歯科栄養学 : 歯科に求められる栄養の基礎知識
  花田, 信弘; 萩原, 芳幸; 北川, 昇, 歯科疾患（う蝕, 歯周病, 咀嚼機能低下）と生活習慣病
  口腔保健協会, Oct. 2018, 9784896053494, vii, 137p, Japanese, [Contributor]
• Geriatric Medicine (老年医学) 56巻 8号
  岩﨑 正則, 口腔と全身の関係一疫学調査からみた口腔とフレイルの関連一
  株式会社 ライフ・サイエンス, Aug. 2018, [Contributor]
• 食と医療 ２０１８ ＳＵＭＭＥＲ－ＦＡＬＬ Ｖｏｌ．６
  岩﨑 正則, 抗酸化ビタミンと歯周病
  講談社, Jun. 2018, [Contributor]
• 口腔保健・予防歯科学
  安井, 利一; 宮崎, 秀夫; 鶴本, 明久; 川口, 陽子; 山下, 喜久; 廣瀬, 公治, 第4章 齲蝕
  医歯薬出版, 2017, 9784263458020, xiv, 303p, Japanese, [Contributor]
• 新臨床研修歯科医ハンドブック
  米田, 雅裕; 廣藤, 卓雄; 粟野, 秀慈; 松浦, 尚志; 馬場, 篤子; 西野, 宇信; 國領, 真也; 村岡, 宏祐, 20-2 う蝕の予防・管理
  医歯薬出版, 2016, 9784263457962, x, 390p, Japanese, [Contributor]
• Annual review 腎臓
  越川, 昭三; 長沢, 俊彦; 伊藤, 克己; 御手洗, 哲也; 富野, 康日己; 柏原, 直樹; 成田, 一衛, 歯周病と腎機能
  中外医学社, 冊, Japanese, [Contributor]

• Potential COPD Burden Reduction under Tobacco Control Scenarios: Projections Using GBD Data
  Yamamoto T, Nomura S, Iwasaki M, Tabuchi T.
  The 36th Annual Scientific Meeting of the Japan Epidemiological Association & the 3rd Joint Scientific Meeting with the IEA Western Pacific Region, 28 Jan. 2026
• 北海道における二次医療圏ごとの歯科訪問診療実施状況と関連する要因の検討
  齋藤光紀, 佐藤美寿々, 善徳勇貴, 本田和枝, 岩崎正則
  北海道歯科衛生士会・北海道口腔保健学会学術合同大会, 札幌市, 30 Nov. 2025
• 北海道における小児口腔健康の経年評価とデータモニタリング体制の現状
  山本貴文, Liu Chang Chang, 岩崎正則
  北海道歯科衛生士会・北海道口腔保健学会学術合同大会, 札幌市, 30 Nov. 2025
• Effects of mastication training on resting-state functional connectivity and cognitive preservation in older adults
  Hayashi Y, Shirobe M, Iwasaki M, Motokawa K, Gomi T, Edahiro A, Kawamura J, Kanno S, Okabayashi K, Hirano H, Ono Y.
  Society for Neuroscience (SFN) Annual Meeting 2025, San Diego, California, USA, 15 Nov. 2025
• 歯と口の健康状態と食との関連について
  岩崎正則
  健康講演会, 余市町, 09 Nov. 2025
  [Invited]
• 定期管理型歯科医院における, メインテナンス患者の動向と分析について
  高橋啓, 丸山和久, 岩崎正則
  ヘルスケアミーティング2025, 文京区, 02 Nov. 2025
• 過疎（人口減少）地域における, 定期管理型歯科医院の状況報告
  高橋啓, 丸山和久, 岩崎正則
  ヘルスケアミーティング2025, 文京区, 02 Nov. 2025
• 高齢者の口腔の健康・機能と栄養、腎疾患
  岩崎正則
  第２回老年・フレイル栄養学研究会 研究講演会, web開催, 01 Nov. 2025
  [Invited]
• 地域在住高齢者における超加工食品の摂取と食品摂取の多様性との関連
  本川佳子、早川美知、三上友里江、白部麻樹、岩崎正則、平野浩彦
  第12回日本サルコペニア・フレイル学会大会, 熊本市, 01 Nov. 2025
• COVID-19パンデミック前後の12歳児DMFTの推移：DDDモデルでの検討
  山本貴文, 竹田飛鳥, 福田英輝, 岩崎正則
  第84回日本公衆衛生学会総会, 静岡市, 29 Oct. 2025
• 後期高齢者における主観的口腔機能低下・歯科受診状況と新規要介護認定との関連
  阿部美也子, 佐藤美寿々, 渡邊裕, 大野幸子, 石丸美穂, 岩崎正則, 平田匠,斎藤民, 樺山舞, 田中和美, 飯島勝矢, 津下一代
  第84回日本公衆衛生学会総会, 静岡市, 29 Oct. 2025
• 地域在住高齢者における郵送調査の継続参加と栄養指標との関連
  本川佳子, 白部麻樹, 岩崎正則, 岡村毅, 宇良千秋, 稲垣宏樹, 宮前史子, 枝広あや子, 笹井浩行, 新開省二, 粟田主一, 平野浩彦
  第84回日本公衆衛生学会総会, 静岡市, 29 Oct. 2025
• 地域在住高齢者における咀嚼機能の6年間の軌跡の探索：お達者健診研究
  白部麻樹, 河合恒, 岩崎正則, 本川佳子, 枝広あや子, 渡邊裕, 笹井浩行, 井原一成, 藤原佳典, 大渕修一, 平野浩彦
  第84回日本公衆衛生学会総会, 静岡市, 29 Oct. 2025
• The effects of foods that require frequent chewing on oral function: A pilot study
  Miura K, Inamoto K, Ozaki K, Okumura T, Tamada Y, Hori A, Abe M, Iwasaki M, Aoki F, Karasawa N, Watanabe Y.
  11th Asian Conference of Frailty and Sarcopenia (ACFS) Kaohsiung City, Taiwan, 17 Oct. 2025
• Descriptive study of occlusal force in older adults using a novel pressure-mapping sensor
  Igarashi K, Iwasaki M, Shirobe M, Heki K, Tatsumi S, Motokawa K, Gomi T, Edahiro A, Sasai H, Hirano H.
  11th Asian Conference of Frailty and Sarcopenia (ACFS) Kaohsiung City, Taiwan, 17 Oct. 2025
• Characteristics associated with the development of Oral Frailty After One Year: The Otassha Study
  Shirobe M, Iwasaki M, Motokawa K, Edahiro A, Watanabe Y, Kawai H, Suzuki H, Sasai H, Ihara K, Fujiwara Y, Obuchi S, Hirano H.
  11th Asian Conference of Frailty and Sarcopenia (ACFS) Kaohsiung City, Taiwan, 17 Oct. 2025
• Association between Fat mass index and Ultra-Processed Food Consumption among Community-Dwelling Older Adults
  Motokawa K, Hayakawa M, Mikami Y, Shirobe M, Iwasaki M, Hirano H.
  11th Asian Conference of Frailty and Sarcopenia (ACFS) Kaohsiung City, Taiwan, 17 Oct. 2025
• コロナ禍における児童生徒の口腔内状況に関する分析
  浅尾友里愛, 内藤真理子, 森川和政, 吉岡香絵, 村井雄司, 岩崎正則, 土岐志麻, 水谷成彦, 長沼善美, 柘植紳平
  第89回全国学校歯科保健研究大会, 広島市, 16 Oct. 2025
• 歯周病をスクリーニングするということ
  岩崎正則
  OralStudio Meeting 2025, 札幌市, 12 Oct. 2025
  [Invited]
• Association between Ultra-Processed Food Consumption and Protein-Energy Ratio among Community-Dwelling Older Adults
  Motokawa K, Hayakawa M, Mikami Y, Shirobe M, Iwasaki M, Hirano H.
  PENSA Congress 2025, Singapore, 07 Oct. 2025
• 〔Major achievements〕The prevention of oral frailty extends the healthy life expectancy
  Iwasaki M
  第25回日本歯科医学会学術大会, 横浜市, 26 Sep. 2025
  [Invited]
• 地域在住高齢者の咀嚼能力と栄養素・食品群別摂取量との関連：お達者健診研究
  本川佳子、白部麻樹、岩崎正則、五味達之祐、大渕修一、平野浩彦
  第25回日本歯科医学会学術大会, 横浜市, 26 Sep. 2025
• 高齢者における血漿中抗Porphyromonas gingivalis抗体価と孤立性収縮期高血圧との関連
  星野剛志,金子昇,葭原明弘,岩崎正則,諏訪間加奈,伊藤由美,田中純太,小川祐司
  第25回日本歯科医学会学術大会, 横浜市, 26 Sep. 2025
• 〔Major achievements〕Community-Based Approaches to Geriatric Oral Health in Japan’s Aging Population
  Iwasaki M
  14th Edition of the Hong Kong International Dental Expo And Symposium, Hong Kong, China, 22 Aug. 2025
  [Invited]
• 〔主要な業績〕高齢者の口の健康状態の推移と現状
  岩崎正則
  第67回日本老年医学会学術集会, 千葉市, 29 Jun. 2025
  [Invited]
• 地域在住高齢者における機能歯数と終末糖化産物の関連：お達者健診研究
  細川知隆, 岩崎正則, 白部麻樹, 本川佳子, 五味達之祐, 枝広あや子, 上野結衣, 正木千尋, 細川隆司, 大渕修一, 平野浩彦
  日本老年歯科医学会第36回学術大会, 千葉市, 27 Jun. 2025
• 居宅介護支援事業所における口腔・栄養スクリーニング加算の活用状況に関する調査
  本川佳子, 白部麻樹, 岩崎正則, 渡邊裕, 平野浩彦
  日本老年歯科医学会第36回学術大会, 千葉市, 27 Jun. 2025
• 地域在住高齢者におけるウェアラブル嚥下計による定量評価と嚥下質問紙評価との関連：板橋健康長寿縦断研究
  白部麻樹, 岩崎正則, 本川佳子, 五味達之祐, 岡村毅, 笹井浩行, 鈴木健嗣, 平野浩彦
  日本老年歯科医学会第36回学術大会, 千葉市, 27 Jun. 2025
• フッ化物応用などのう蝕予防について
  岩崎正則
  一般社団法人北海道歯科衛生士会令和７年度トピックス研修会, 札幌市, 25 May 2025
  [Invited]
• 幼少期の逆境体験とポジティブな経験がその後の歯痛に与える影響：横断研究
  山本貴文,佐藤美寿々,岩崎正則,田淵貴大
  第74回日本口腔衛生学会学術大会, 新潟市, 16 May 2025
• 食事摂取におけるNa/K比と現在歯数との関連（魚沼コホート研究）第二報：調味料・食品との関連
  諏訪間加奈, 伊藤由美, 岩崎正則, 中村夢衣, 柴田佐都子, 竹原祥子, 葭原明弘
  第74回日本口腔衛生学会学術大会, 新潟市, 16 May 2025
• 地域在住高齢者における咀嚼困難感と独居およびうつ傾向の関連
  白木光, 角田聡子, 木村友美, 岩崎正則, 安細敏弘
  第74回日本口腔衛生学会学術大会, 新潟市, 16 May 2025
• 食事摂取におけるナトリウム／カリウム（Na/K）摂取比と現在歯数との関連（魚沼コホート研究）第一報
  中村夢衣, 岩崎正則, 伊藤由美, 諏訪間加奈, 柴田佐都子, 竹原祥子, 葭原明弘
  第74回日本口腔衛生学会学術大会, 新潟市, 16 May 2025
• 〔主要な業績〕オーラルフレイルについて
  香川県県民公開講座, 香川市, 22 Mar. 2025
  [Invited]
• Relationship Between Drinking Habits and Tooth Loss: A Five-Year Cohort Study
  Suwama K, Iwasaki M, Ito Y, Tanaka J, Kabasawa K, Yoshihara A.
  2025 AADOCR/CADR Annual Meeting & Exhibition, NY, United States, 12 Mar. 2025
• 〔主要な業績〕口腔の健康と全身の関連
  岩﨑正則
  第27回健康栄養シンポジウム, WEB開催, 15 Feb. 2025
  [Invited]
• 歯・口腔の健康と食事・栄養
  北海道大学歯学部同窓会札幌支部講演会, 札幌市, 07 Dec. 2024
  [Invited]
• 〔主要な業績〕高齢者の口腔機能と食 ・栄養 -疫学的知見のご紹介-
  秋田県栄養士会, 令和6年度生涯教育研修会, WEB開催, 07 Dec. 2024
  [Invited]
• Efforts to maintain and improve nutritional status by using an app to monitor eating habits
  Motokawa K, Shirobe M, Iwasaki M, Hirano H.
  West Pacific Rim Consortium on Healthy Aging 2024, Nagoya, Japan, 28 Nov. 2024
• 高齢者の口腔機能と食 ・栄養 -疫学的知見のご紹介-
  岩崎正則
  福岡高齢者医療研究会（S.O.N.Y-MED）, WEB開催, 19 Nov. 2024
  [Invited]
• OF-5を用いたオーラルフレイル評価における該当項目数と生活機能低下の関連～お達者健診研究～
  白部麻樹, 岩崎正則, 本川佳子, 枝広あや子, 五味達之祐, 渡邊裕, 江尻愛美, 河合恒, 笹井浩行, 井原一成, 藤原佳典, 大渕修一, 平野浩彦
  第11回日本サルコペニア・フレイル学会, 千代田区, 02 Nov. 2024
• フレイル予防に向けた日本人の食事摂取基準2020年版たんぱく質目標量未達成者の食生活に関する記述疫学研究：お達者健診研究
  五味達之祐, 本川佳子, 白部麻樹, 早川美知, 岩崎正則, 枝広あや子, 河合恒, 笹井浩行, 井原一成, 藤原佳典, 大渕修一, 平野浩彦
  第11回日本サルコペニア・フレイル学会, 千代田区, 02 Nov. 2024
• オーラルフレイルおよび食品摂取多様性低値の重積がフレイルに及ぼす影響～お達者研究～
  本川佳子, 白部麻樹, 岩崎正則, 枝広あや子, 五味達之祐, 渡邊裕, 江尻愛美, 河合恒, 笹井浩行, 井原一成, 藤原佳典, 大渕修一, 平野浩彦
  第11回日本サルコペニア・フレイル学会, 千代田区, 02 Nov. 2024
• 複数のたばこ製品使用は歯痛と関連するか：横断研究
  山本貴文, 佐藤美寿々, 岩崎正則, 田淵貴大
  第83回日本公衆衛生学会総会, 札幌市, 29 Oct. 2024
• 〔主要な業績〕口腔機能と栄養・食生活に関するエビデンス
  岩﨑正則
  第83回日本公衆衛生学会総会, 札幌市, 29 Oct. 2024
  [Invited]
• A study on diagnostic algorithm for Oral Hypofunction based on the JSG diagnostic criteria (JSG: Japanese Society of Gerontology)
  Hirano H, Igarashi K, Murakami M, Kugimiya Y, Shirobe M, Edahiro A, Iwasaki M.
  10th Asian Conference of Frailty and Sarcopenia, Bangkok Thailand, 10 Oct. 2024
• Association Between the Oral Frailty 5-item Checklist (OF-5) and Oral Function: The Otassha Study
  Shirobe M, Iwasaki M, Motokawa K, Edahiro A, Gomi T, Watanabe Y, Ejiri M, Kawai H, Sasai H, Ihara K, Fujiwara Y, Obuchi S, Hirano H.
  10th Asian Conference of Frailty and Sarcopenia, Bangkok Thailand, 10 Oct. 2024
• Association between Dietary Inflammatory Index and oral frailty among community-dwelling older adults: The Otassha Study
  Motokawa K, Iwasaki M, Shirobe M, Hayakawa M, Edahiro A, Gomi T, Watanabe Y, Ejiri1 M, Kawai H, Sasai H, Ihara K, Fujiwara Y, Obuchi S, Hirano H.
  10th Asian Conference of Frailty and Sarcopenia, Bangkok Thailand, 10 Oct. 2024
• 認知症重症度と口腔衛生管理の課題との関連
  白部麻樹, 岩崎正則, 本川佳子, 枝広あや子, 五味達之祐, 渡邊裕, 江尻愛美, 河合恒, 笹井浩行, 井原一成, 藤原佳典, 大渕修一, 平野浩彦
  日本歯科衛生学会 第19回学術大会, 新潟市, 21 Sep. 2024
• Is skeletal muscle mass index a clinically useful diagnostic marker for sarcopenia?: Itabashi Longitudinal Study on Aging
  Osuka Y, Hatanaka S, Kojima N, Shida T, Ohta T, Motokawa K, Edahiro A, Shirobe M, Iwasaki M, Hirano H, Awata S, Sasai H.
  20th EuGMS CONGRESS, Valencia, Spain, 18 Sep. 2024
• 新たに整理されたオーラルフレイルの概念と評価指標（OF-5）について
  札幌歯科医師会・役員勉強会, 札幌市, 12 Sep. 2024
  [Invited]
• 通所介護事業所における口腔・栄養への取組と歯科治療ニーズとの関連
  本川佳子, 白部麻樹, 岩佐康行, 岩崎正則, 栗原明子, 渡邊裕, 平野浩彦, 荒井秀典
  第30回日本摂食嚥下リハビリテーション学会学術大会, 福岡市, 30 Aug. 2024
• 〔Major achievements〕The importance of oral function in older adults from the viewpoint of healthy longevity
  Masanori Iwasaki
  Asian Rising Stars Symposium 2024, WEB開催, 27 Jul. 2024
  [Invited]
• Association between regular dental check-ups and oral frailty in community-dwelling older people: the Otassha Study
  Matsubara C, Shirobe M, Motokawa K, Edahiro A, Gomi T, Iwasaki M, Ejiri M, Kawai H, Sasai H, Fujiwara Y, Obuchi S, Hirano H.
  International Symposium on Dental Hygiene, Seoul, South Korea, 11 Jul. 2024
• Oral function in middle-aged and older Japanese adults
  Shirobe M, Iwasaki M, Igarashi K, Motokawa K, Edahiro A, Morishita S, Matsubara C, Gomi T, Ejiri M, Kawai H, Inoue M, Yamaguchi S, Isobe A, Hikiji H, Nishihara T, Sasai H, Fujiwara Y, Obuchi S, Hirano H.
  International Symposium on Dental Hygiene, Seoul, South Korea, 11 Jul. 2024
• 頭部振戦を伴う後期高齢者に認められた下顎大臼歯舌側に穿孔した根管治療器具異物の1例
  原田祥二, 藤田真理, 菅野真人, 浮田万由美, 江端正祐, 岩崎正則, 山崎裕
  日本老年歯科医学会第35回学術大会, 札幌市, 28 Jun. 2024
• 壮年期および高齢期における口腔機能低下に関する実態調査
  白部麻樹, 岩崎正則, 五十嵐憲太郎, 本川佳子, 枝広あや子, 森下志穂, 松原ちあき, 五味達之祐, 江口佳奈, 大渕修一, 平野浩彦
  日本老年歯科医学会第35回学術大会, 札幌市, 28 Jun. 2024
• 地域在住高齢者における定期歯科受診状況とオーラルフレイル（OF-5）の関連性の検討：お達者健診研究
  松原ちあき, 白部麻樹, 本川佳子, 枝広あや子, 五味達之祐, 岩崎正則, 大渕修一, 平野浩彦
  日本老年歯科医学会第35回学術大会, 札幌市, 28 Jun. 2024
• 食習慣サポートアプリの食品多様性への影響
  早川美知, 本川佳子, 坂田穏行, 加藤麻奈, 白部麻樹, 岩﨑正則, 大渕修一, 平野浩彦
  日本老年歯科医学会第35回学術大会, 札幌市, 28 Jun. 2024
• 〔主要な業績〕スポンサードレクチャー 新たに整理されたオーラルフレイルの概念と評価指標（OF-5）について
  岩﨑正則
  日本老年歯科医学会第35回学術大会, 札幌市, 28 Jun. 2024
  [Invited]
• 地域在住高齢者における口腔機能低下症と食品摂取多様性の関連：お達者研究
  五味達之祐, 本川佳子, 白部麻樹, 岩崎正則, 枝広あや子, 早川美知, 河合恒, 藤原佳典, 大渕修一, 平野浩彦
  第66回日本老年医学会学術集会, 名古屋市, 13 Jun. 2024
• Use of machine learning to optimize dietary variety of older adults
  Motokawa K, Arisaka N, Kalantar L, Shirobe M, Iwasaki M, Gomi T, Eguchi K, Hirano H.
  The 19th International Congress of Nutrition and Dietetics, Toronto, Canada, 12 Jun. 2024
• 地域在住高齢者におけるエイジズムと関連要因の分析
  稲垣宏樹,宇良千秋,枝広あや子,杉山美香,宮前史子,岩崎正則,笹井浩行,岡村毅,平野浩彦,粟田主一
  日本老年社会科学会 第66回大会, 奈良市, 01 Jun. 2024
• Relationship Between Alcohol Consumption and Tooth Loss: A Five-year Cohort Study
  Suwama K, Iwasaki M, Ito Y, Tanaka J, Kabasawa K, Yoshihara A.
  International Collaborative Symposium on Development of Human Resources in Practical Oral Health and Treatment 2024, Bangkok,Thailand, 31 May 2024
• 開業医の学術活動 第3報 －学術雑誌への投稿－
  原田祥二, 藤田真理, 菅野真人, 浮田万由美, 江端正祐, 森田学, 岩崎正則
  第73回日本口腔衛生学会学術大会, 盛岡市, 10 May 2024
• Effect of Periodontal Therapy on Glycemic Control in Type2 Diabetes
  Sato M, Ono S, Yamana,H, Okada A, Ishimaru M, Ono Y, Iwasaki M, Aida J, Yasunaga H.
  2024 IADR/AADOCR/CADR General Session & Exhibition, New Orleans, LA, USA, 13 Mar. 2024
• 糖尿病をもつ人における歯科受診状況の推移と糖尿病ガイドライン改定の影響
  佐藤美寿々, 大野幸子, 山名隼人, 石丸美穂, 岡田啓, 大野洋介, 横田勲, 岩崎正則, 康永秀生
  第34回日本疫学会学術総会, 大津市, 31 Jan. 2024
• 地域在住高齢者における日常の食生活の咀嚼行動と年齢の関連
  江口佳奈, 本川佳子, 岩崎正則, 白部麻樹, 五味達之祐, カランタル玲奈, 早川美知, 枝広あや子, 稲垣宏樹, 笹井浩行, 粟田主一, 平野浩彦
  第27回日本病態栄養学会年次学術集会, 京都市, 26 Jan. 2024
• 開業医の学術活動 第2報 －日本口腔衛生学会での発表－
  原田祥二, 藤田真理, 浮田万由美, 菅野真人, 江端正祐, 森田学, 岩崎正則.
  第13回北海道口腔保健学会総会・学術大会, 札幌市, 26 Nov. 2023
• 当科通院中に結核を発症した患者の診療に際して感染症法による接触者健康診断受診勧告となった経験
  原田祥二, 藤田真理, 菅野真人, 江端正祐, 森田学, 岩崎正則.
  第13回北海道口腔保健学会総会・学術大会, 札幌市, 26 Nov. 2023
• Predictive factors for swallowing function decline in older adults with Alzheimer's disease: a 1-year longitudinal study
  Shirobe M, Edahiro A, Motokawa M, Morishita S, Iwasaki M, Watanabe Y, Hirano H.
  Asian Dysphagia Society 2023 International Conference, Seoul, Korea, 09 Nov. 2023
• Association of Serum 25(OH)D Levels with Oral Function in Community-Dwelling Older Adults
  Motokawa K, Iwasaki M, Shirobe M, Sakata Y, Kato M, Kawakami S, Obuchi S, Kawai H, Hirano H.
  Asian Dysphagia Society 2023 International Conference, Seoul, Korea, 09 Nov. 2023
• A study on diagnostic algorithm for Oral Hypofunction based on the JSG diagnostic criteria
  Hirano H, Motokawa K, Shirobe M, Edahiro A, Igarashi K, Iwasaki M.
  Asian Dysphagia Society 2023 International Conference, Seoul, Korea, 09 Nov. 2023
• Antibody Levels against Porphyromonas Gingivalis and Isolated Systolic Hypertension in Japanese Older Adults
  Hoshino T, Kaneko N, Yoshihara A, Iwasaki M, Suwama K, Ito Y, Tanaka J, Narita I, Ogawa H.
  The 15th International Conference of Asian Academy of Preventive Dentistry, Hong Kong, China, 08 Nov. 2023
• 地域在住高齢者における色変わりガムの測定値の分布
  釘宮嘉浩, 岩崎正則, 白部麻樹, 本川佳子, 枝広あや子, 渡邊裕, 五十嵐憲太郎, 阿部巧, 横山友里, 北村明彦, 村山洋史, 平野浩彦.
  第16回日本口腔検査学会学術大会, 千代田区, 04 Nov. 2023
• アルツハイマー病の重症度に応じた嚥下機能評価の実施可否と栄養状態
  白部麻樹, 枝広あや子, 本川佳子, 森下志穂, 岩崎正則, 渡邊裕, 平野浩彦.
  第16回日本口腔検査学会学術大会, 千代田区, 04 Nov. 2023
• 咀嚼機能の客観評価と主観評価の乖離と将来のサルコペニア発症リスクとの関連性について -お達者研究-
  村上正治, 釘宮嘉浩, 中村純也, 岩崎正則, 本川佳子, 枝広あや子, 白部麻樹, 河合恒, 大渕修一, 藤原佳典, 井原一成, 平野浩彦.
  第10回日本サルコペニア・フレイル学会大会, 千代田区, 04 Nov. 2023
• 〔主要な業績〕スポンサードシンポジウム2 サルコペニア・フレイルと口腔機能「オーラルフレイルの評価～新５項目（OF-5）の詳細～」
  岩﨑正則
  第10回日本サルコペニア・フレイル学会大会, 千代田区, 04 Nov. 2023
  [Invited]
• 会食を行う通いの場の参加者減少に関連する要因：ソーシャルマーケティングの視点
  五味達之祐, 本川佳子, 白部麻樹, 岩﨑正則, 枝広あや子, 大渕修一, 藤原佳典, 荒井秀典, 粟田主一, 平野浩彦.
  第82回日本公衆衛生学会総会, つくば市, 31 Oct. 2023
• 〔Major achievements〕Evaluation and management of oral function in an ageing population from the viewpoint of oral frailty and oral hypofunction
  Masanori Iwasaki
  International Association of Gerontology and Geriatrics-Asia/Oceania Regional Congress 2023 Satellite Symposium on Gerodontolog, 26 Oct. 2023
  [Invited]
• Effect of home-visit-based nutritional support by registered dietitian on the dietary habits of home-care residents
  Motokawa K, Shirobe M, Iwasaki M, Hirano H.
  第23回アジア静脈経腸栄養学会議, 台北, 台湾, 19 Oct. 2023
• Nutritional status and feasibility of swallowing function evaluation according to the severity of Alzheimer's disease
  Shirobe M, Edahiro A, Motokawa K, Morishita S, Iwasaki M, Watanabe Y, Hirano H.
  第23回アジア静脈経腸栄養学会議, 台北, 台湾, 19 Oct. 2023
• シンポジウム3「歯科口腔保健と骨の健康・身体機能」
  岩崎正則
  第43回日本骨形態計測学会, 30 Jun. 2023
  [Invited]
• 合同シンポジウム15 高齢者の定義―その後の展開と展望「⼝の⽼化の経時的データ」
  第33回日本老年学会総会, 18 Jun. 2023
  16 Jun. 2023 - 18 Jun. 2023, [Invited]
• 静電容量型感圧センサーシートを用いた咬合力測定の信頼性および成人の基準値の予備的検討
  五十嵐憲太郎, 栗谷川輝, 目黒郁美, 鈴木到, 釘宮嘉浩, 石井智浩, 伊藤誠康, 有川量崇, 岩崎正則, 平野浩彦, 河相安彦.
  日本老年歯科医学会第34回学術大会, 横浜市, 16 Jun. 2023
• 非経口栄養管理中の要介護高齢者に対する口腔衛生管理に関する検討
  松原ちあき, 白部麻樹, 枝広あや子, 本川佳子, 森下志穂, 本橋佳子, 岩崎正則, 渡邊裕, 平野浩彦.
  日本老年歯科医学会第34回学術大会, 横浜市, 16 Jun. 2023
• 要介護高齢者における認知症と歯科治療および口腔衛生管理ニーズの関係
  森下志穂, 白部麻樹, 枝広あや子, 本川佳子, 本橋佳子, 岩崎正則, 渡邊裕, 平野浩彦.
  日本老年歯科医学会第34回学術大会, 横浜市, 16 Jun. 2023
• アルツハイマー型認知症重症度と口腔機能評価実施可否に関する検討
  白部麻樹, 枝広あや子, 本川佳子, 森下志穂, 本橋佳子, 岩崎正則, 渡邊裕, 平野浩彦.
  日本老年歯科医学会第34回学術大会, 横浜市, 16 Jun. 2023
• 地域在住高齢者における社会的孤立と栄養状態に関する横断的検討：板橋健康長寿縦断研究
  カランタル玲奈, 本川佳子, 岩崎正則, 早川美知, 三上友里江, 白部麻樹, 平野浩彦, 笹井浩行, 稲垣宏樹, 宮前史子, 枝広あや子, 岡村毅, 粟田主一.
  第65回日本老年医学会学術集会, 横浜市, 16 Jun. 2023
• 地域在住高齢者のサルコペニア頻度の2012年から2017年の推移：長寿コホートの総合的研究（ILSA-J）
  大塚礼, 西田裕紀子, 牧迫飛雄馬, 鄭丞媛, 阿部巧, 島田裕之, 鈴木隆雄, ILSA-J Group.
  第65回日本老年医学会学術集会, 横浜市, 16 Jun. 2023
• JST版活動能力指標との関連性における身体機能と認知機能の差異：長寿コホートの総合的研究（ILSA-J）
  阿部巧, 藤原佳典, 北村明彦, 野藤悠, 西田裕紀子, 牧迫飛雄馬, 鄭丞媛, 大塚礼, 鈴木隆雄, ILSA-J Group.
  第65回日本老年医学会学術集会, 横浜市, 16 Jun. 2023
• Association of Oral Frailty with Medical Expenditure in Older Japanese Adults
  Arai E, Watanabe Y, Nakagawa S, Ohara Y, Iwasaki M, Hirano H, Ikebe K, Ono T, Iijima K, Adachi A, Watanabe T, Yamazaki Y.
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）, 横浜市, 12 Jun. 2023
• Association between oral health management and maintenance of food form of older adults residing in long-term care facilities under the pandemic of COVID-19
  Inamoto K, Abe T, Watanabe Y, Yamazaki Y, Ohara Y, Iwasaki M, Hirano H, Tsuneishi M, Kodama T, Yoshida M, Minakuchi S.
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）, 横浜市, 12 Jun. 2023
• Relationship between dietary vitamin C and physical performance among older Japanese: Itabashi Longitudinal Study on Aging
  Saito K, Kojima N, Osuka Y, Motokawa K, Hayakawa M, Mikami Y, Iwasaki M, Inagaki H, Miyamae F, Okamura T, Hirano H, Awata S, Sasai H.
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）, 横浜市, 12 Jun. 2023
• Association of polypharmacy with the severity of frailty in community-dwelling older adults: Itabashi Longitudinal Study on Aging
  Daimaru K, Osuka Y, Kojima N, Mizukami K, Motokawa K, Iwasaki M, Inagaki H, Miyamae F, Okamura T, Hirano H, Awata S, Sasai1 H.
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）, 横浜市, 12 Jun. 2023
• Development and validation of a simple equation for identifying sarcopenia using bioelectrical impedance-derived metrics
  Shida T, Osuka Y, Kojima N, Hatanaka S, Ohta T, Motokawa K, Iwasaki M, Inagaki H, Miyamae F, Okamura T, Hirano H, Awata S, Sasai H.
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）, 横浜市, 12 Jun. 2023
• The Questionnaire for medical checkups of old-old in determining frailty is equivalent to the Kihon checklist: equivalence testing.
  Deguchi N, Osuka Y, Kojima N, Motokawa K, Iwasaki M, Inagaki H, Miyamae F, Okamura T, Hirano H, Awata S, Sasai H.
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）, 横浜市, 12 Jun. 2023
• Association between masseter muscle mass and Upper limb muscle mass in older adults requiring long-term care
  Miura K, Iwasaki M, Edahiro A, Motokawa K, Shirobe M, Hayakawa M, Mikami Y, Kalantar L, Motohashi Y, Igarashi K, Ohara Y, Watanabe Y, Hirano H
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）, 横浜市, 12 Jun. 2023
• Association between Functional Assessment Staging of Alzheimer's Disease and oral hygiene management issues for older adults with Alzheimer's disease.
  Shirobe M, Edahiro A, Motokawa K, Morishita M, Ohara Y, Motohashi Y, Iwasaki M, Watanabe Y, Hirano H
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）, 横浜市, 12 Jun. 2023
• Association between serum albumin redox state and dietary protein intake among community-dwelling older adults: Itabashi Longitudinal Study on Aging
  Motokawa K, Mikami Y, Iwasaki M, Wada Y, Tabata F, Hayakawa M, Shirobe M, Kalantar L, Osuka Y, Kojima N, Sasai H, Inagaki H, Miyamae F, Okamura T, Hirano H, Awata S.
  第12回IAGGアジア/オセアニア国際老年学会議（IAGG-AOR2023）, 横浜市, 12 Jun. 2023
• シンポジウム2「歯周疾患検診等を含めた歯科健診の課題と今後」セルフレポートから得られる口腔情報と健診・疫学調査への活用
  岩崎正則
  日本口腔衛生学会第72回学術大会, 大阪府, 20 May 2023, Nominated symposium
  [Invited]
• 握力の測定方法の違いがサルコペニア有病割合に及ぼす影響：欧米式と日本式の比較
  志田隆史, 大須賀洋祐, 小島成実, 本川佳子, 岩崎正則, 稲垣宏樹, 宮前史子, 岡村毅, 平野浩彦, 粟田主一, 笹井浩行
  第24回日本健康支援学会年次学術大会, 福岡市, 04 Mar. 2023
• 都市在住高齢者におけるスマートウォッチへの関心に関連する要因の性差：板橋健康長寿縦断研究
  出口直樹, 小島成実, 大須賀洋祐, 本川佳子, 岩崎正則, 稲垣宏樹, 宮前史子, 岡村毅, 平野浩彦, 粟田主一, 笹井浩行
  第24回日本健康支援学会年次学術大会, 福岡市, 04 Mar. 2023
• 口腔と長寿の文献レヴュー
  岩崎正則
  TUNAGERD会, WEB開催, 28 Feb. 2023
  [Invited]
• 高齢者の口腔機能と食・栄養 -疫学的知見のご紹介-
  秋田県歯科医師会, 口腔と栄養研修会, WEB開催, 15 Jan. 2023
  [Invited]
• 都市に暮らす高齢者の日常生活行動頻度の基礎的研究：板橋健康長寿縦断研究
  佐久間尚子, 稲垣宏樹, 宮前史子, 枝広あや子, 杉山美香, 宇良千秋, 山下真里, 本川佳子, 白部麻樹, 岩崎正則, 小島成実, 大須賀洋祐, 笹井浩行, 平野浩彦, 岡村毅, 粟田主一
  第41回日本認知症学会学術集会 第37回日本老年精神医学会 合同開催, 千代田区, 12 Nov. 2022
• 要介護高齢者における咬筋量と体肢筋量の関連
  三浦和仁, 岩崎正則, 枝広あや子, 本川佳子, 白部麻樹, 早川美知, 三上友里江, カランタル玲奈, 本橋佳子, 五十嵐憲太郎, 小原由紀, 渡邊裕, 平野浩彦
  第15回日本口腔検査学会総会・学術大会, 横浜市, 12 Nov. 2022
• 栄養指標と位相角の関連性の横断的検証：板橋健康長寿縦断研究
  本川佳子, 岩崎正則, 早川美知, 三上友里江, 白部麻樹, 大須賀洋祐, 小島成実, 畑中翔, 笹井浩行, 稲垣宏樹, 宮前史子, 枝広あや子, 岡村毅, 平野浩彦, 粟田主一
  第9回日本サルコペニア・フレイル学会大会, 草津市, 29 Oct. 2022
• 口腔機能とサルコペニアの関係の検討：Otassya・Kusatsu Studyからの知見
  釘宮嘉浩, 岩﨑正則, 本川佳子, 枝広あや子, 白部麻樹, 渡邊裕, 大渕修一, 河合恒, 江尻愛美, 伊藤久美子, 阿部巧, 藤原佳典, 北村明彦, 新開省二, 平野浩彦
  第9回日本サルコペニア・フレイル学会大会, 草津市, 29 Oct. 2022
• Association between masseter muscle mass and skeletal muscle mass in older adults requiring long-term care
  Miura K, Iwasaki M, Edahiro A, Motokawa K, Shirobe M, Hayakawa M, Mikami M, Kalantar L, Motohashi Y, Igarashi K, Ohara Y, Watanabe Y, Hirano H.
  The 8th Asian Conference for Frailty and Sarcopenia, Nagoya, Japan, 27 Oct. 2022
• 口の健康・機能と全身の健康 -栄養状態や運動機能を中心に-
  岩崎正則
  公益財団法人ロッテ財団 第4回噛むこと健康研究会, 21 Oct. 2022, Nominated symposium
  [Invited]
• 認知症の人への歯科診療困難事例の実態調査報告
  白部麻樹, 枝広あや子, 森下志穂, 岩崎正則, 小原由紀, 本川佳子, 井藤佳恵, 粟田主一, 恒石美登里, 平野浩彦
  第81回日本公衆衛生学会総会, 甲府市, 07 Oct. 2022
• 高齢者を対象とした口腔機能低下症のスクリーニング方法の検討：お達者研究
  釘宮嘉浩, 岩崎正則, 小原由紀, 本川佳子, 枝広あや子, 白部麻樹, 渡邊裕, 井原一成, 大渕修一, 藤原佳典, 平野浩彦.
  第81回日本公衆衛生学会総会, 甲府市, 07 Oct. 2022
• 通いの場における管理栄養士・栄養士の関与の実態と効果-全国郵送調査から-
  本川佳子, 白部麻樹, 岩崎正則, 平野浩彦
  第69回日本栄養改善学会学術総会, 岡山市, 16 Sep. 2022
• 〔主要な業績〕地域在住高齢者におけるCDC・AAP歯周病質問票日本語版の妥当性の検討：お達者健診研究
  岩崎正則, 小原由紀, 本川佳子, 白部麻樹, 早川美知, 枝広あや子, 河合恒, 渡邊裕, 井原一成, 藤原佳典, 大渕修一, 平野浩彦
  第65回秋季日本歯周病学会学術大会, 仙台市, 02 Sep. 2022
• Low Dietary Variety and Diabetes Mellitus Are Associated with Frailty among Community-Dwelling Older Japanese Adults: A Cross-Sectional Study
  Hayakawa M, Motokawa K, Mikami Y, Shirobe M, Edahiro A, Iwasaki M, Ohara Y, Watanabe Y, Kawai H, Kojima M, Obuchi S, Fujiwara Y, Kim H, Ihara K, Inagaki H, Shinkai S, Awata S, Araki A, Hirano H.
  The 8th Asian Congress of Dietetics (ACD2022), Kanagawa, Japan, 19 Aug. 2022
• Relationship between Eating Alone and Poor Appetite Using the Simplified Nutritional Appetite Questionnaire
  Mikami Y, Motokawa K, Shirobe M, Edahiro A, Ohara Y, Iwasaki M, Hayakawa M, Watanabe Y, Inagaki H, Kim H, Shinkai S, Awata S, Hirano H.
  The 8th Asian Congress of Dietetics (ACD2022), Kanagawa, Japan, 19 Aug. 2022
• Relationship Between Chewing Ability and Nutritional Status in Japanese Older Adults: A Cross-Sectional Study
  Motokawa M, Mikami Y, Shirobe M, Edahiro A, Ohara Y, Iwasaki M, Watanabe Y, Kawai H, Kera T, Obuchi S, Kim H, Fujiwara Y, Ihara K, Hirano H
  The 8th Asian Congress of Dietetics (ACD2022), Kanagawa, Japan, 19 Aug. 2022
• 高齢者の口腔機能に影響を与える新規歯周組織評価指標の横断調査による検証
  上野結衣, 岩崎正則, 野代知孝, 宗政翔, 向坊太郎, 近藤祐介, 正木千尋, 平野浩彦, 細川隆司
  日本補綴歯科学会第131回学術大会, 大阪市, 15 Jul. 2022
• 静電容量型感圧センサシートを用いた咬合力測定装置による咬合力の基準値の検討
  目黒郁美, 五十嵐憲太郎, 岩崎正則, 伊藤誠康, 河相安彦, 渡邊裕, 平野浩彦
  日本補綴歯科学会第131回学術大会, 大阪市, 15 Jul. 2022
• シンポジウム3「補綴治療は患者の何を改善できるか？：臨床アウトカムを多角的に評価する」健康な口腔から得られるもの -食・栄養を中心に-
  岩崎正則
  日本補綴歯科学会第131 回学術大会, 15 Jul. 2022, Nominated symposium
  [Invited]
• 認知症の人と家族が経験した歯科通院での困りごととそれに対する工夫
  枝広あや子, 白部麻樹, 平野浩彦, 岩崎正則, 本川佳子, 小原由紀, 大堀嘉子, 井藤佳恵, 岡村毅, 粟田主一
  第23回日本認知症ケア学会大会, 広島市, 18 Jun. 2022
• Oral Hygiene Management Issues For Oolder Adults With Alzheimer’s Disease
  Shirobe M, Edahiro A, Motokawa K, Ohara Y, Morishita S, Motohashi Y, Iwasaki M, Watanabe Y, Hirano H.
  The 22nd IAGG World Congress of Gerontology and Geriatrics, 12 Jun. 2022
• 通所介護サービス利用者における低栄養リスクに関連する要因の検討
  小原由紀, 岩崎正則, 白部麻樹, 岩佐康行, 森下志穂, 恒石美登里, 小玉剛, 平野浩彦, 渡邉裕, 吉田光由, 水口俊介
  日本老年歯科医学会第33回学術大会, 新潟市, 10 Jun. 2022
• 脳卒中と現在歯数および身体活動量の関連
  中村夢衣, 諏訪間加奈, 柴田佐都子, 岩崎正則, 葭原明弘
  第71回日本口腔衛生学会・総会, 鹿児島市, 13 May 2022
• 〔主要な業績〕日本人中年期男女における睡眠時間と歯周病の関連
  岩崎正則, 臼井通彦, 有吉渉, 中島啓介, 吉岡香絵, 井上真紀, 小林薫, 西原達次
  第32回日本疫学会学術総会, 東京都, 26 Jan. 2022
• 認知症重症度に注目したアルツハイマー型認知症高齢者の口腔衛生管理課題に関する検討
  白部麻樹, 枝広あや子, 本川佳子, 小原由紀, 森下志穂, 本橋佳子, 岩崎正則, 渡邊裕, 平野浩彦
  第80回日本公衆衛生学会総会, 東京都, 21 Dec. 2021
• 大都市地域在住高齢者における「かかりつけ歯科医」の有無とフレイルとの関連についての検討
  小原由紀, 枝広あや子, 岩崎正則, 本川佳子, 稲垣宏樹, 横山友里, 粟田主一, 北村明彦, 新開省二, 平野浩彦
  第80回日本公衆衛生学会総会, 東京都, 21 Dec. 2021
• 〔主要な業績〕COVID-19流行下の定期的歯科受診の中断が高校生の口腔の健康に与える影響
  岩崎正則, 角田聡子, 安細敏弘
  第80回日本公衆衛生学会総会, 東京都, 21 Dec. 2021
• オーラルフレイル予防
  岩崎正則
  特別区人事・厚生事務組合特別区職員研修所 専門研修「歯科保健」, 01 Dec. 2021, Public discourse
  [Invited]
• 通いの場に参加している地域在住高齢者の口腔機能に関する検討
  白部麻樹, 本川佳子, 小原由紀, 岩崎正則, 枝広あや子, 渡邊裕, 井原一成, 金憲経, 大渕修一, 藤原佳典, 平野浩彦
  第8回日本サルコペニア・フレイル学会大会, 大阪市, 06 Nov. 2021
• サルコペニアが口腔機能に与える影響の縦断的検討：お達者健診研究
  釘宮嘉浩, 岩崎正則, 小原由紀, 本川佳子, 枝広あや子, 白部麻樹, 渡邊裕, 河合恒, 大渕修一, 藤原佳典, 井原一成, 上田貴之, 平野浩彦
  第8回日本サルコペニア・フレイル学会大会, 大阪市, 06 Nov. 2021
• 腸内細菌叢に関連する口腔機能関連指標の探索―20～40代を対象とした予備的検討―
  小原由紀, 松原ちあき, 高橋知佳, 岩崎正則, 平野浩彦
  第8回日本サルコペニア・フレイル学会大会, 大阪市, 06 Nov. 2021
• フレイル予防を目的とした中食の栄養成分表示活用に関する検討
  本川佳子, 奈良一寛, 小林知未, 飯坂真司, 岩崎正則, 早川美知, 三上友里江, 渡邊裕, 大渕修一, 粟田主ー, 平野浩彦
  第8回日本サルコペニア・フレイル学会大会, 大阪市, 06 Nov. 2021
• 地域在住高齢女性におけるフレイル・サルコペニア診断項目と認知機能低下との関連について－お達者健診研究
  上田由美子, 小島成実, 大須賀洋祐, 笹井浩行, 本川佳子, 小原由紀, 岩崎正則, 平野浩彦, 金憲経
  第8回日本サルコペニア・フレイル学会大会, 大阪市, 06 Nov. 2021
• 地域在住高齢女性における身体的フレイルを伴う尿失禁の特徴－お達者健診研究
  金憲経, 小島成実, 大須賀洋祐, 笹井浩行, 本川佳子, 小原由紀, 岩崎正則, 平野浩彦
  第8回日本サルコペニア・フレイル学会大会, 大阪市, 06 Nov. 2021
• 地域在住高齢女性における心理的フレイルの特徴－お達者健診研究
  青木登紀子, 小島成実, 大須賀洋祐, 笹井浩行, 本川佳子, 小原由紀, 岩崎正則, 平野浩彦, 金憲経
  第8回日本サルコペニア・フレイル学会大会, 大阪市, 06 Nov. 2021
• 有料老人ホーム入居におけるフレイル移行の要因に関する検討
  石本恭子, 和田泰三,中本宇彦, 木村友美, 加藤恵美子, 竜野真維, 広崎真弓, 平山貴一, 吉田升, 角田聡子, 岩崎正則, 藤澤道子, 青山薫, 松林公蔵, 坂本龍太
  第8回日本サルコペニア・フレイル学会大会, 大阪市, 06 Nov. 2021
• 〔主要な業績〕咬筋量は全身の骨格筋量および口腔機能と関連するか：日本人地域在住高齢者を対象とした横断研究
  岩崎正則, 平野浩彦, 本川佳子, 白部麻樹, 枝広あや子, 小原由紀, 河合恒, 小島基永, 大渕修一, 村山洋史, 藤原佳典, 井原一成, 新開省二, 北村明彦
  第8回日本サルコペニア・フレイル学会大会, 大阪市, 06 Nov. 2021
• A qualitative analysis of difficulties experienced by people living with dementia and their families while visiting the dentist
  Edahiro A, Shirobe M, Hirano H, Iwasaki M, Motokawa K, Ohara Y, Oohori Y, Ito K, Okamura T, Awata S
  International Psychogeriatric Association International Congress 2021 Virtual Congress, 01 Nov. 2021
• シンポジウム8「口腔機能と血管病」
  岩崎正則
  第53回日本動脈硬化学会総会・学術集会, 23 Oct. 2021, Nominated symposium
  [Invited]
• 歯科口腔保健と全身の健康 - 主に骨の健康に着目して -
  岩崎正則
  都市高齢者の健康長寿医療研究会「医科歯科連携・口腔機能管理」, 板橋区, 16 Sep. 2021
  [Invited]
• 地域在住高齢者の口腔機能低下症の有病率と評価項目間の関連性の検討：お達者健診研究
  五十嵐憲太郎, 釘宮嘉浩, 岩崎正則, 小原由紀, 白部麻樹, 枝広あや子, 本川佳子, 河合恒, 大渕修一, 藤原佳典, 井原一成, 渡邊裕, 伊藤誠康, 河相安彦, 平野浩彦
  第14回日本口腔検査学会総会・学術大会, ウェブ開催, 21 Aug. 2021
• サルコペニアと関連する口腔機能低下症の下位症状の検討：お達者健診研究
  釘宮嘉浩, 五十嵐憲太郎, 岩崎正則, 小原由紀, 本川佳子, 枝広あや子, 白部麻樹, 渡邊裕, 河合恒, 大渕修一, 藤原佳典, 井原一成, 上田貴之, 平野浩彦
  第14回日本口腔検査学会総会・学術大会, ウェブ開催, 21 Aug. 2021
• 〔主要な業績〕日本人高齢者における全身の骨格筋量, 咬筋量, 口腔機能, 歯の状態の関連
  岩崎正則, 平野浩彦, 本川佳子, 白部麻樹, 枝広あや子, 小原由紀, 河合恒, 小島基永, 大渕修一, 村山洋史, 藤原佳典, 井原一成, 新開省二, 北村明彦
  第14回日本口腔検査学会総会・学術大会, WEB, 21 Aug. 2021
• Exploring the effects of oral frailty and malnutrition overlap on frailty in community-dwelling elderly: a 2-year longitudinal study
  Motokawa K, Iwasaki M, Shirobe M, Hayakawa M, Edahiro A, Ohara Y, Inagaki H, Watanabe Y, Awata S, Shinkai S, Hirano H.
  第2回世界嚥下サミット, 名古屋市, 21 Aug. 2021
• Dietary diversity and sarcopenia in Japanese elderly people
  Kakuta S, Park J, Hamasaki T, Iwasaki M, Ansai T.
  2021 IADR/PER General Session & Exhibition, Boston, MASS., U.S., 21 Jul. 2021
• Relationship between alcohol consumption and number of present teeth in community-dwelling Japanese
  Suwama K, Yoshihara A, Kaneko N, Hoshino T, Minagawa K, Iwasaki M, Ito Y, Tanaka J, Narita I.
  2021 IADR/PER General Session & Exhibition, Boston, MASS., U.S., 21 Jul. 2021
• Validation of the Trypsin-like Peptidase Activity Assay for Periodontitis Detection
  Nishihara T, Iwasaki M, Usui M, Ariyoshi W, Nakashima K, Nagai-Yoshioka Y, Inoue M, Kobayashi K.
  2021 IADR/PER General Session & Exhibition, Boston, MASS., U.S., 21 Jul. 2021
• 〔Major achievements〕Validation of Self-reported Measures of Periodontitis in a Japanese Population
  Iwasaki M, Usui M, Ariyoshi W, Nakashima K, Nagai-Yoshioka Y, Inoue M, Kobayashi K, Borgnakke WS, Taylor GW, Nishihara T.
  2021 IADR/PER General Session & Exhibition, Boston, MA, U.S., 21 Jul. 2021
• 特別シンポジウム「人生100年時代に向けての歯科的ロードマップ」口腔と長寿の文献レヴュー -健康長寿社会の実現を目指す戦略を支える 歯科的エビデンスの充実に向けて-
  岩崎正則
  第32回日本老年歯科医学会学術大会, 12 Jun. 2021, Nominated symposium
  [Invited]
• 地域在住高齢者における舌圧低下に関連する因子の検討：2年間の縦断研究
  高橋知佳, 岩崎正則, 小原由紀, 白部麻樹, 枝広あや子, 本橋佳子, 本川佳子, 渡邊裕, 平野浩彦
  日本老年歯科医学会第31回学術大会, ウェブ開催, 11 Jun. 2021
• 高齢者における唾液検査装置に関する調査―口腔内の検査項目と多項目唾液検査結果の比較―
  松原ちあき, 白部麻樹, 古屋純一, 渡邊裕, 本川佳子, 枝広あや子, 小原由紀, 岩崎正則, 大渕修一, 平野浩彦, 水口俊介
  日本老年歯科医学会第31回学術大会, ウェブ開催, 11 Jun. 2021
• 口腔機能低下症とサルコペニアの関連の検討：The Otassha Study
  釘宮嘉浩, 岩崎正則, 小原由紀, 本川佳子, 枝広あや子, 白部麻樹, 渡邊裕, 大渕修一, 平野 浩彦, 上田貴之
  日本老年歯科医学会第31回学術大会, ウェブ開催, 11 Jun. 2021
• 要介護高齢者における義歯不使用 に関連する因子の検討
  目黒郁美, 小原由紀, 枝広あや子, 本川佳子, 白部麻樹, 岩崎正則, 五十嵐憲太郎, 伊藤誠康, 渡邊裕, 河相安彦, 平野浩彦
  日本老年歯科医学会第31回学術大会, ウェブ開催, 11 Jun. 2021
• 口腔乾燥感が身体的フレイル発現に与える影響の検討―地域在住高齢者における5年間の縦断研究―
  小原由紀, 白部麻樹, 岩崎正則, 枝広あや子, 本川佳子, 渡邊裕, 大渕修一, 平野浩彦
  日本老年歯科医学会第31回学術大会, ウェブ開催, 11 Jun. 2021
• 〔主要な業績〕地域在住高齢者における居住状況と認知機能にみた栄養状態と体組成
  岩崎正則, 本川佳子, 渡邊裕, 白部麻樹, 稲垣宏樹, 枝広あや子, 小原由紀, 平野浩彦, 新開省二, 粟田主一
  第63回日本老年医学会学術集会, WEB, 11 Jun. 2021
• 高齢者における日本版地中海食スコアと生命予後との関連性
  朴祗佑, 角田聡子, 濱嵜朋子, 岡田圭子, 青佐泰志, 酒井理恵, 芹田千穂, 茂山博代, 片岡正太, 筒井修一, 岩崎正則, 安細敏弘
  第70回日本口腔衛生学会, ウェブ開催, 27 May 2021
• Oral Hypofunction. Oral hypofunction and malnutrition -Findings from an epidemiological study of community-dwelling older adults-
  Masanori Iwasaki
  3rd International Gerodontology Symposium, 10 Apr. 2021, Nominated symposium
  [Invited]
• Association between dry mouth and physical frailty among community-dwelling older adults in Japan: the Otassha Study
  Ohara Y, Shirobe M, Iwasaki M, Motokawa K, Edahiro A, Kawai H, Kim H, Fujiwara Y, Ihara K, Watanabe Y, Obuchi S, Hirano H.
  European College of Gerodontology, Bern, Switzerland (hybrid), 09 Apr. 2021
• 地域在住高齢者における口腔関連QOLとフレイルの関連についての縦断研究
  角田聡子, 岩崎正則, 木村友美, 廣島屋貴俊, 朴祇佑, 石本恭子, 和田泰三, 坂本龍太, 藤澤道子, 奥宮清人, 松林公蔵, 安細敏弘, 小川祐司
  第7回日本サルコペニア・フレイル学会大会, ウェブ開催, 01 Dec. 2020
• 地域在住高齢者におけるオーラルフレイル・低栄養の重複とフレイルの関連
  本川佳子, 小原由紀, 白部麻樹, 枝広あや子, 岩崎正則, 渡邊裕, 河合恒, 解良武士, 大渕修一, 平野浩彦
  第7回日本サルコペニア・フレイル学会大会, ウェブ開催, 01 Dec. 2020
• 80歳以上の有料老人ホーム入居プレフレイル高齢者における要介護因子の検討
  石本恭子, 和田泰三,中本宇彦, 木村友美, 加藤恵美子, 竜野真維, 広崎真弓, 平山貴一, 吉田升, 角田聡子, 岩崎正則, 藤澤道子, 青山薫, 松林公蔵, 坂本龍太
  第7回日本サルコペニア・フレイル学会大会, ウェブ開催, 01 Dec. 2020
• 地域在住高齢者における歯周疾患リスクとフレイルの関連：2年間の縦断研究
  松原ちあき, 白部麻樹, 岩崎正則, 小原由紀, 枝広あや子, 本川佳子, 稲垣宏樹, 渡邊裕, 平野浩彦, 古屋純一, 水口俊介, 新開省二, 粟田主一
  第7回日本サルコペニア・フレイル学会大会, ウェブ開催, 01 Dec. 2020
• 会食の通いの場の実施内容および参加者の口腔機能に関する実態報告
  白部麻樹, 本川佳子, 小原由紀, 枝広あや子, 岩崎正則, 荒井秀典, 粟田主一, 大渕修一, 小玉剛, 武井典子, 西村一弘, 藤原佳典, 平野浩彦
  第7回日本サルコペニア・フレイル学会大会, ウェブ開催, 01 Dec. 2020
• Remaining Tooth Numbers and Falls in the Community-dwelling Japanese Elderly
  Watanabe M, Nohno K, Hoshino T, Tamura K, Ogawa H, Kakuta S, Iwasaki M, Ishimoto Y, Kimura Y, Wada T, Sakamoto R, Fujisawa M, Okumiya K, Matsubayashi K.
  International Association for Dental Research of South East Asia division, Online, 26 Nov. 2020
• 急性期病院入院患者の口腔状態に影響を与える全身的因子
  柴田佳苗, 近藤祐介, 岩崎正則, 正木千尋, 藤井航, 細川隆司
  日本老年歯科医学会第31回学術大会, オンライン, 07 Nov. 2020
• Factors associated with hyposalivation among community-dwelling older Japanese population in longitudinal study.
  Ohara Y, Kawai H, Shirobe M, Motokawa K, Fujiwara Y, Kim H, Ihara K, Obuchi S, Edahiro A, Iwasaki M, Watanabe Y, Hirano H.
  30th Annual Congress of The European College of Gerodontology, online, 09 Oct. 2020
• 地域在住高齢者の高次ADL低下とフレイルとの関連
  木村友美, 石本恭子, 岩崎正則, 坂本龍太, 笠原順子, 藤澤道子, 加藤恵美子, 竜野真維, 和田泰三, 松林公蔵
  第62回日本老年医学会学術集会, オンライン, 04 Aug. 2020
• 地域在住後期高齢者における残存歯数と転倒の関連
  渡辺真光, 濃野要, 星野剛志, 田村浩平, 角田聡子, 岩崎正則, 石本恭子, 木村友美, 坂本龍太, 小川祐司
  第62回日本老年医学会学術集会, オンライン, 04 Aug. 2020
• 地域在住高齢者は人工的水分・栄養方法についてのアドバンス・ケア・プランニング（ACP）を望んでいるか？
  和田泰三, 竜野真維, 藤澤道子, 木村友美, 岩崎正則, 石本恭子, 加藤恵美子, 平山貴一, 松林公蔵, 坂本龍太
  第62回日本老年医学会学術集会, オンライン, 04 Aug. 2020
• 認知症重症度別の口腔衛生管理に関わる拒否等の症状の実態把握
  白部麻樹, 枝広あや子, 小原由紀, 森下志穂, 本川佳子, 本橋佳子, 五十嵐憲太郎, 岩崎正則, 渡邊裕, 平野浩彦
  日本歯科衛生学会第15回学術大会, 誌上開催, 01 Aug. 2020
• 高校生におけるインターネット依存度と永久歯う蝕との関連
  佐藤美寿々, 皆川久美子, 宮本茜, 岩崎正則
  第69回日本口腔衛生学会, 誌上開催, 24 Apr. 2020
• 国民健康・栄養調査における高齢者の歯の保有状況と歯科疾患実態調査への協力の関連
  安藤雄一, 池田奈由, 田野ルミ, 岩崎正則, 西信雄, 三浦宏子
  第30回日本疫学会学術総会, 京都市, 20 Feb. 2020
• 平成28年歯科疾患実態調査協力者の特性：国民健康・栄養調査リンケージデータの分析
  安藤雄一, 池田奈由, 田野ルミ, 岩崎正則, 西信雄, 三浦宏子
  第78回日本公衆衛生学会総会, 高知市, 23 Oct. 2019
• Qualitative research on nutrition improvement measures at adult daycare facilities in Japan
  Motokawa K, Ohara Y, Shirobe M, Edahiro A, Iwasaki M, Hirano H, Watanabe Y.
  the 11th International Association of Gerontology and Geriatrics Asia/Oceania Regional Congress, Taiwan, 23 Oct. 2019
• 歯科訪問事業参加高齢者を対象とした食品摂取の多様性評価
  岡田圭子, 濱嵜朋子, 朴祇佑, 岩崎正則, 筒井修一, 安細敏弘.
  第41回九州口腔衛生学会総会, 北九州市, 23 Sep. 2019
• 乳幼児のう蝕罹患に関する要因の検討.
  木畠可南子, 邵仁浩, 仲山智恵, 片岡正太, 角田聡子, 岩崎正則, 安細敏弘.
  第41回九州口腔衛生学会総会, 北九州市, 23 Sep. 2019
• バス運転手を対象とした咀嚼機能と栄養摂取に関する横断研究.
  川島芙蓉子, 正木千尋, 福原正代, 角田聡子, 片岡正太, 岩崎正則, 安細敏弘, 細川隆司.
  第41回九州口腔衛生学会総会, 北九州市, 23 Sep. 2019
• 臨床研究 文献検索・文献の読み方・研究方法
  岩崎正則
  公益社団法人 日本歯科衛生士会 認定研修「医科歯科連携・口腔機能管理」, 13 Sep. 2019
  [Invited]
• 口腔保健と栄養 -これまでのエビデンスと今後の展望-
  岩崎正則
  第28回日本健康教育学会学術大会, 29 Jun. 2019
  [Invited]
• Appetite Modifies the Association between Chewing Ability and Dynapenia
  Hiroshimaya T, Iwasaki M, Kakuta S, Ansai T, Ogawa H, Kimura Y, Wada T, Sakamoto R, Ishimoto Y, Fujisawa M, Okumiya K, Matsubayashi M.
  2019 IADR/PER General Session & Exhibition, Vancouver, Canada, 19 Jun. 2019
• 農村地域における高齢者の食行動と健康度との関連
  木村友美, 坂本龍太, 和田泰三, 藤澤道子, 奥宮清人, 石本恭子, 加藤恵美子, 竜野真維, 岩崎正則, 松林公蔵
  第61回日本老年医学会学術集会, 仙台市, 06 Jun. 2019
• 〔主要な業績〕地域在住高齢者における高次生活機能の加齢変化パターンと歯の本数の関連：10年間の前向きコホート研究
  岩崎正則, 佐藤美寿々, 葭原明弘
  第30回日本老年歯科医学会学術大会, 仙台市, 06 Jun. 2019
• 動脈硬化と歯周病との関連: 地域在住高齢者を対象とした横断研究
  佐藤美寿々, 岩崎正則, 皆川久美子, 山賀孝之, 小川祐司
  第68回日本口腔衛生学会・総会, 大津市, 22 May 2019
• バス運転手における糖尿病, 不眠度, 食習慣および歯周病の関連 (第一報)
  芹田千穂, 片岡正太, 廣島家貴俊, 茂山博代, 角田聡子, 福原正代, 正木千尋, 岩崎正則, 安細敏弘
  第68回日本口腔衛生学会・総会, 大津市, 22 May 2019
• 地域在宅超高齢者の食事パターンと栄養状態, 栄養素摂取量および嚥下との関連
  濱嵜朋子, 岩崎正則, 角田聡子, 片岡正太, 濃野要, 葭原明弘, 小川祐司, 安細敏弘, 宮崎秀夫
  第68回日本口腔衛生学会・総会, 大津市, 22 May 2019
• 地域在住高齢者における咀嚼能力, 食欲とダイナベニアとの関連
  廣島家貴俊, 岩崎正則, 角田聡子, 安細敏弘
  第68回日本口腔衛生学会・総会, 大津市, 22 May 2019
• 高齢者の低栄養予防における歯科の役割 -地域に根ざした調査結果を中心に-
  岩崎正則
  島根県歯科医師会・島根県健康福祉部健康推進課 高齢者の低栄養予防対策研修会, 24 Feb. 2019
  [Invited]
• Ten-year survival of immediate-loading implants in fully edentulous maxilla in the Asian population: A multilevel analysis
  Kondo Y, Masaki C, Tamura A, Mukaibo T, Tsuka S, Iwasaki M, Ansai T, Hosokawa R.
  11th Asian Academy of Prosthodontics 2018, Malaysia, 21 Sep. 2018
• 地域在住在宅高齢者の口腔健康と全身的健康との関連
  川畑美沙, 邵仁浩, 本田茂代, 木畠可南子, 仲山智恵, 片岡正太, 角田聡子, 岩崎正則, 安細敏弘
  第40回九州口腔衛生学会総会, 鹿児島市, 09 Sep. 2018
• 乳幼児のう蝕罹患に関する要因の分析
  木畠可南子, 邵仁浩, 本田茂代, 仲山智恵, 片岡正太, 角田聡子, 岩崎正則, 安細敏弘
  第40回九州口腔衛生学会総会, 鹿児島市, 09 Sep. 2018
• 乳幼児のう蝕多発に関する要因の検討
  本田茂代, 邵仁浩, 木畠可南子, 仲山智恵, 片岡正太, 角田聡子, 岩崎正則, 安細敏弘
  第40回九州口腔衛生学会総会, 鹿児島市, 09 Sep. 2018
• 75歳以上在宅要介護高齢者における舌圧と食事摂取量の関連
  廣島屋貴俊, 岩崎正則, 酒井理恵, 角田聡子, 濱嵜朋子, 片岡正太, 筒井修一, 安細敏弘
  第40回九州口腔衛生学会総会, 鹿児島市, 09 Sep. 2018
• 臨床研究 文献検索・文献の読み方・研究方法
  岩崎正則
  公益社団法人 日本歯科衛生士会 認定研修「医科歯科連携・口腔機能管理」, 北九州市, 07 Sep. 2018
  [Invited]
• 〔主要な業績〕歯の本数の加齢に伴う変化の軌跡と生命予後の関連：新潟コホート研究の特徴を活かしたエビデンスの創出
  岩崎正則
  第17回コロキウム, 東京都, 12 Aug. 2018
• Pre-Sarcopenia Was Associated with Oral Function in Older Adults
  Kakuta S, Hiroshimaya T, Iwasaki M, Tomoe M, Ansai T.
  2018 IADR/PER General Session & Exhibition, London, England, 25 Jul. 2018
• The Salivary Microbiota of Patients with Aggressive Periodontitis
  Yoshida A, Nakano Y, Iwasaki M, Shioya K, Bouziane A, Erraji S, Lakhdar L, Rhissassi M, Ansai T, Miyazaki H, Ennibi O.
  2018 IADR/PER General Session & Exhibition, London, England, 25 Jul. 2018
• Olive Oil Intake is Inversely Related to Aggressive Periodontitis Prevalence
  Miyazaki H, Iwasaki M, Bouziane A, Erraji S, Lakhdar L, Rhissassi M, Yoshida A, Ansai T, Ennibi O.
  2018 IADR/PER General Session & Exhibition, London, England, 25 Jul. 2018
• 〔Major achievements〕Simultaneous Adherence to Multiple Healthy Lifestyle Components Can Prevent Periodontitis
  Iwasaki M, Borgnakke WS, Ogawa H, Sato M, Minagawa K, Ansai T, Yoshihara A, Miyazaki H.
  2018 IADR/PER General Session & Exhibition, London, England, 25 Jul. 2018
• The effect of Gli-similar 3 gene polymorphism on the relationship between periodontitis and renal function in postmenopausal Japanese women
  Takamisawa K, Sugita N, Yoshihara A, Iwasaki M, Che Y, Kuroki A, Miyazaki H, Nakamura K, Yoshie H.
  EUROPERIO9, Amsterdam, Netherlands, 20 Jun. 2018
• 施設入所高齢者にみられる全身のサルコペニアと口腔機能の低下との関係
  角田聡子, 廣島屋貴俊, 岩崎正則, 邵仁浩, 片岡正太, 芹田千穂, 巴美樹, 安細敏弘
  第67回日本口腔衛生学会・総会, 札幌市, 18 May 2018
• 平成28年歯科疾患実態調査おける協力状況について
  安藤雄一, 柳澤智仁, 岩崎正則, 北村雅保, 竹内倫子, 玉置洋
  第67回日本口腔衛生学会・総会, 札幌市, 18 May 2018
• 乳幼児のう蝕発生に関する1歳6か月児歯科健診の有効性について
  本田茂代, 邵仁浩, 仲山智恵, 片岡正太, 角田聡子, 岩崎正則, 安細敏弘
  第67回日本口腔衛生学会・総会, 札幌市, 18 May 2018
• 地域在宅超高齢者の栄養状態と栄養素摂取量との関連
  濱嵜朋子, 岩崎正則, 角田聡子, 片岡正太, 濃野要, 葭原明弘, 安細敏弘, 宮崎秀夫
  第67回日本口腔衛生学会・総会, 札幌市, 18 May 2018
• 唾液中揮発性有機化合物の分子情報に基づく非侵襲的口腔がん診断の可能性
  安細敏弘, 茂山博代, 角田聡子, 岩崎正則, 片岡正太, 邵仁浩, 粟野秀慈
  第67回日本口腔衛生学会・総会, 札幌市, 18 May 2018
• 納豆摂取と歯の喪失との関連：地域在住閉経後女性を対象とした縦断研究
  佐藤美寿々, 岩崎正則, 皆川久美子, 葭原明弘, 宮崎秀夫
  第67回日本口腔衛生学会・総会, 札幌市, 18 May 2018
• 〔主要な業績〕Periodontal disease and pneumonia mortality in haemodialysis patients:A 7-year cohort study
  岩崎正則
  第67回日本口腔衛生学会・総会, 札幌市, 18 May 2018
• 〔主要な業績〕高次生活機能の加齢に伴う変化の軌跡と歯の本数の関連についての縦断研究
  岩崎正則, 佐藤美寿々, 皆川久美子, 安細敏弘, 葭原明弘, 小川祐司, 宮崎秀夫
  第67回日本口腔衛生学会・総会, 札幌市, 18 May 2018
• 平成28年歯科疾患実態調査協力者のサンプル特性と住民基本台帳人口データとの比較
  安藤雄一, 柳澤智仁, 岩崎正則, 北村雅保, 竹内倫子, 玉置洋
  第28回日本疫学会総会, 福島市, 01 Feb. 2018
• Consideration of tooth loss in ancient Japanese
  Kataoka S, Iwasaki M, Kakuta S, Soh I, Ansai T.
  17th International Symposium on Dental Morphology (ISDM) & 2nd congress of International Association for Paleodontology (IAPO), Bordeaux, France, 04 Oct. 2017
• 歯・口腔の健康と栄養
  岩崎正則
  長崎市歯科医師会・歯科健診協力歯科医部会・研修会, 21 Sep. 2017, Public discourse
  [Invited]
• 施設利用高齢者の食欲指標SNAQと栄養状態および健康関連QOLとの関連性について
  山田志麻, 岩崎正則, 濱嵜朋子, 増田渉, 田川辰也, 角田聡子, 安細敏弘
  第64回日本栄養改善学会学術集会, 徳島市, 13 Sep. 2017
• 〔主要な業績〕高齢者における口腔保健と栄養
  岩崎正則
  第16回コロキウム, 東京都, 10 Sep. 2017
• 乳幼児のう蝕罹患に関する地域格差について
  本田茂代, 邵仁浩, 仲山智恵, 片岡正太, 角田聡子, 岩崎正則, 安細敏弘
  第39回九州口腔衛生学会総会, 佐賀市, 03 Sep. 2017
• 歯肉炎バイオマーカーとしての洗口吐出液の有用性に関する検討-その2-
  角田聡子, 岩崎正則, 邵仁浩, 片岡正太, 鶴田実穂, 秋山理加, 茂山博代, 廣島屋貴俊, 横田誠, 牛島直文, 安細敏弘
  第39回九州口腔衛生学会総会, 佐賀市, 03 Sep. 2017
• 仮性口臭症傾向に関わる心理特性に関する検討
  安細敏弘, 鶴田実穂, 片岡正太, 角田聡子, 邵仁浩, 岩崎正則
  第39回九州口腔衛生学会総会, 佐賀市, 03 Sep. 2017
• 臨床研究 文献検索・文献の読み方・研究方法
  岩崎正則
  公益社団法人 日本歯科衛生士会 認定研修「医科歯科連携・口腔機能管理」, 北九州市, 01 Sep. 2017
  [Invited]
• THP-1細胞におけるPorphyromonas gingivalis由来LPS刺激によるMAEA発現の解析
  車玉蘭, 杉田典子, 高橋直紀, 岩崎正則, 葭原明弘, 宮崎秀夫, 吉江弘正
  平成29年度新潟歯学会第1回例会, 新潟市, 01 Jul. 2017
• 地域在住高齢者のフレイルと食事摂取状況との関連
  木村友美, 石本恭子, 岩崎正則, 笠原順子, 坂本龍太, 和田泰三, 奥宮清人, 藤津道子, 松林公蔵
  第59回日本老年医学会学術集会, 名古屋市, 14 Jun. 2017
• 地域在住高齢者におけるフレイルスコアと転倒スコアの関連
  石本恭子, 木村友美, 岩崎正則, 和田泰三, 笠原順子, 坂本龍太, 藤澤道子, 奥宮清人, 松林公蔵
  第59回日本老年医学会学術集会, 名古屋市, 14 Jun. 2017
• 刺激唾液分泌量低下と総死亡率との関連：地域在住高齢者における10年間のコホート研究
  佐藤美寿々, 岩崎正則, 伊藤加代子, 濃野要, 葭原明弘, 宮崎秀夫
  第28回日本老年歯科医学会学術大会, 名古屋市, 14 Jun. 2017
• 〔主要な業績〕地域在住高齢者における最大咬合力とフレイルとの関連：5年間の前向きコホート研究
  岩崎正則, 葭原明弘, 佐藤(五十嵐)直子, 佐藤美寿々, 安細敏弘, 小野高裕, 宮崎秀夫
  第28回日本老年歯科医学会学術大会, 名古屋市, 14 Jun. 2017
• 在宅医療利用高齢者における舌圧と骨格筋量の減少の関連
  廣島屋貴俊, 岩崎正則, 角田聡子, 邵仁浩, 酒井理恵, 濱嵜朋子, 石田昌嗣, 平良祥, 松本研一, 筒井修一, 安細敏弘
  第66回日本口腔衛生学会・総会, 山形市, 31 May 2017
• 唾液中揮発性有機化合物の分子情報に基づいた非侵襲的口腔がん診断アプローチ
  茂山博代, 角田聡子, 岩崎正則, 邵仁浩, 粟野秀慈, 安細敏弘
  第66回日本口腔衛生学会・総会, 山形市, 31 May 2017
• Longitudinal association between dentition status and frailty in community-dwelling older adults
  Sato M, Iwasaki M, Minagawa K, Yoshihara A, Miyazaki H.
  第66回日本口腔衛生学会・総会, 山形市, 31 May 2017
• 〔主要な業績〕地域在住高齢者における健康習慣と歯の喪失・歯周病リスクの関連
  岩崎正則, 葭原明弘, 佐藤美寿々, 安細敏弘, 宮崎秀夫
  第66回日本口腔衛生学会・総会, 山形市, 31 May 2017
• 唾液中揮発性有機化合物の分子情報をマーカーとする口腔がん診断のアプローチ
  茂山博代, 角田聡子, 岩崎正則, 邵仁浩, 粟野秀慈, 上原雅隆, 富永和宏, 吉岡泉, 安細敏弘
  第77回九州歯科学会総会・学術大会, 北九州市, 20 May 2017
• ミャンマーネピドー在住の小児を対象とした口腔内状況の実態と課題
  廣島屋貴俊, 岩崎正則, 角田聡子, 邵仁浩, 片岡正太, 安細敏弘, 西原達次
  第77回九州歯科学会総会・学術大会, 北九州市, 20 May 2017
• Influence of social anxiety on pathologic subjective halitosis
  Tsuruta M, Kataoka S, Iwasaki M, Kakuta S, Iwasaki M, Soh I, Awano S, Ansai T.
  Asia-Pacific Conference in Fukuoka 2017, Kitakyushu, Japan, 11 May 2017
• Evaluation of Partially Edentulous Arch in Ancient Japanese
  Kataoka S, Iwasaki M, Kakuta S, Soh I, Ansai T.
  2017 IADR/AADR/CADR General Session & Exhibition, San Fransisco, CA, U.S., 22 Mar. 2017
• Volatile Organic Compounds from Healthy and Oral Cancer Saliva Samples
  Shigeyama H, Wang T, Kakuta S, Iwasaki M, Soh I, Awano S, Uehara M, Yoshioka I, Tominaga K, Lee SW, Ansai T.
  2017 IADR/AADR/CADR General Session & Exhibition, San Fransisco, CA, U.S., 22 Mar. 2017
• 〔Major achievements〕Pneumonia Mortality Is Associated With Periodontitis in Patients Undergoing Hemodialysis
  Iwasaki M, Taylor GW, Awano S, Yoshida A, Hamasaki T, Teratani G, Soh I, Ansai T, Nakamura H.
  2017 IADR/AADR/CADR General Session & Exhibition, San Francisco, CA, U.S., 22 Mar. 2017
• 慢性腎臓病と歯科疾患
  岩崎正則
  食と健康を学ぼう, 05 Mar. 2017, Public discourse
  [Invited]
• 臨床研究 文献検索・文献の読み方・研究方法
  岩崎正則
  公益社団法人 日本歯科衛生士会 認定研修「医科歯科連携・口腔機能管理」, 北九州市, 09 Sep. 2016
  [Invited]
• 縄文人骨における下顎隆起のベイジアンネットワークを用いた考察
  片岡正太, 岩崎正則, 邵仁浩, 角田聡子, 廣島屋貴俊, 安細敏弘
  第38回九州口腔衛生学会総会, 福岡市, 03 Sep. 2016
• 歯肉炎バイオマーカーとしての洗口吐出液の有用性に関する検討
  角田聡子, 岩崎正則, 邵仁浩, 秋山理加, 片岡正太, 茂山博代, 鶴田実穂, 平山綾, 廣島屋貴俊, 横田誠, 午島直文, 安細敏弘
  第38回九州口腔衛生学会総会, 福岡市, 03 Sep. 2016
• 75歳以上在宅高齢者における全身の骨格筋量と舌圧の関連
  廣島屋貴俊, 岩崎正則, 角田聡子, 邵仁浩, 酒井理恵, 濱嵜朋子, 石田昌嗣, 平良祥, 松本研一, 筒井修一, 安細敏弘
  第38回九州口腔衛生学会総会, 福岡市, 03 Sep. 2016
• 乳幼児のう蝕罹患に関する要因分析について（第2報）
  邵仁浩, 森高久恵, 毛利正昭, 板家隆, 土肥直史, 藤井雅洋, 今村均, 仲山智恵, 角田聡子, 岩崎正則, 安細敏弘
  第38回九州口腔衛生学会総会, 福岡市, 03 Sep. 2016
• Effects of ritual tooth extraction on oral disease
  Kataoka S, Ansai T, Iwasaki M
  8th World Archaeological Congress, Kyoto, Japan, 28 Aug. 2016
• Relationship Between Ritual Tooth Extraction and Para-functional Disease
  Kataoka S, Takahashi T, Iwasaki M, Tsuruta M, Kakuta S, Soh I, Ansai T
  IADR/AADR/CADR General Session & Exhibition, Seoul, Republic of Korea, 22 Jun. 2016
• Jikoshu-Kyofu with one's own foul mouth odor and psychological scales
  Tsuruta M, Takahashi T, Kataoka S, Kakuta S, Soh I, Iwasaki M, Ansai T
  IADR/AADR/CADR General Session & Exhibition, Seoul, Republic of Korea, 22 Jun. 2016
• Nutritional status changes in elderly individuals living at home: results of a 2-year study
  Hamasaki T, Iwasaki M, Sakai R, Kakuta S, Soh I, Yoshihara A, Ansai T, Miyazaki H
  IADR/AADR/CADR General Session & Exhibition, Seoul, Republic of Korea, 22 Jun. 2016
• Bidirectional relationship between renal function and periodontal disease in older Japanese women
  Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K
  IADR/AADR/CADR General Session & Exhibition, Seoul, Republic of Korea, 22 Jun. 2016
• Macrophage erythroblast attacher gene polymorphism and periodontitis in postmenopausal women
  Che Y, Sugita N, Takahashi N, Yoshihara A, Hanai Y, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H
  IADR/AADR/CADR General Session & Exhibition, Seoul, Republic of Korea, 22 Jun. 2016
• 在宅高齢者における口腔ケア介入と栄養素摂取との関連
  酒井理恵, 濱嵜朋子, 岩崎正則, 邵仁浩, 角田聡子, 石田昌嗣, 平良祥, 松本研一, 筒井修一, 安細敏弘
  第65回日本口腔衛生学会・総会, 東京都, 27 May 2016
• 風習的抜歯と口腔内パラファンクショナル疾患との関連
  片岡正太, 岩崎正則, 鶴岡実穂, 角田聡子, 邵仁浩, 安細敏弘
  第65回日本口腔衛生学会・総会, 東京都, 27 May 2016
• ベイジアンネットワークを用いた口臭に固執する自己臭恐怖と心理尺度の因果関係解析
  鶴田実穂, 片岡正太, 角田聡子, 邵仁浩, 岩崎正則, 安細敏弘
  第65回日本口腔衛生学会・総会, 東京都, 27 May 2016
• 歯科診療所における子ども参加型職業体験を通した受診への動機づけの試み
  峰岡哲郎, 徳冨順子, 角田聡子, 邵仁浩, 岩崎正則, 吉田明弘, 粟野秀慈, 安細敏弘
  第65回日本口腔衛生学会・総会, 東京都, 27 May 2016
• 唾液中の揮発性口腔がんバイオマーカーの探索および臨床応用に向けたアプローチ
  茂山博代, 角田聡子, 岩崎正則, 邵仁浩, 粟野秀慈, 安細敏弘
  第65回日本口腔衛生学会・総会, 東京都, 27 May 2016
• 在宅高齢者における簡易嚥下状態評価（EAT-10）と2年後の健康状態との関連
  秋山理加, 浜崎朋子, 酒井理恵, 岩崎正則, 角田聡子, 邵仁浩, 葭原明弘, 宮崎秀夫, 安細敏弘
  第65回日本口腔衛生学会・総会, 東京都, 27 May 2016
• 在宅高齢者における体重変化と歯数および栄養素摂取量との関連
  濱嵜朋子, 酒井理恵, 岩崎正則, 角田聡子, 邵仁浩, 葭原明弘, 宮崎秀夫, 安細敏弘
  第65回日本口腔衛生学会・総会, 東京都, 27 May 2016
• 透析患者における健康関連Quality of Lifeと唾液分泌量との関連
  有永靖, 岩崎正則, 粟野秀慈, 片岡正太, 邵仁浩, 角田聡子, 伊藤加代子, 吉田明弘, 安細敏弘
  第65回日本口腔衛生学会・総会, 東京都, 27 May 2016
• The relationship between macrophage erythroblast attacher (MAEA) gene polymorphism and periodontitis in postmenopausal Japanese women
  Che Y, Sugita N, Yoshihara A, Hanai Y, Iwasaki M, Miyazaki H, Yoshie H.
  第59回春季日本歯周病学会学術大会, 鹿児島市, 20 May 2016
• 80歳地域住民における糖尿病と歯周病の生命予後への影響
  田上綾香, 園木一男, 秋房住郎, 高田豊, 福原正代, 粟野秀慈, 角田聡子, 邵仁浩, 岩崎正則, 安細敏弘
  第59回春季日本歯周病学会学術大会, 鹿児島市, 20 May 2016
• Analysis of Volatile Organic Compounds in Human Saliva via Zeolite-Based Thin-Film Micro-extraction Coupled with Gas Chromatography-Mass Spectrometry
  Shigeyama H, Wang T, Kakuta S, Iwasaki M, Soh I, Awano S, Lee SW, Ansai T
  Asia-Pacific Conference in Fukuoka 2016, Kitakyushu, 11 May 2016
• UCP2遺伝子多型が閉経後女性の歯周炎と腎機能の関係に及ぼす影響
  杉田典子, 葭原明弘, 花井悠貴, 岩崎正則, 宮崎秀夫, 吉江弘正
  第58回秋季日本歯周病学会学術大会, 浜松市, 12 Sep. 2015
• 学童期における歯肉炎評価のためのGCFの応用
  角田聡子, 岩崎正則, 邵仁浩, 鶴田実穂, 平山綾, 片岡正太, 茂山博代, 横田誠, 牛島直文, 安細敏弘
  第37回九州口腔衛生学会総会, 長崎市, 06 Sep. 2015
• 認知症等要介護高齢者の口腔ケアと食事支援に関する調査
  邵仁浩, 田中徹, 仲山智恵, 角田聡子, 岩崎正則, 安細敏弘
  第37回九州口腔衛生学会総会, 長崎市, 06 Sep. 2015
• 歯の健康 これだけは知っておきたい口の健康を守るコツ
  岩崎正則
  北九州市立年長者研修大学校周望学舎研修, 29 Jun. 2015, Public discourse
  [Invited]
• 地域在住高齢者におけるフレイル（虚弱）と現在歯数との関連についての横断研究
  佐藤美寿々, 岩崎正則, 葭原明弘, 宮崎秀夫
  甲信越北陸口腔保健研究会 第26回総会・学術大会, 富山市, 13 Jun. 2015
• The effect of macrophage erythroblast attacher (MAEA) gene polymorphism on the relationships between periodontitis and bone mineral density in postmenopausal Japanese women
  Che Y, Sugita N, Yoshihara A, Wang Y, Hanai Y, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  EuroPerio 8, London, 03 Jun. 2015
• Relationships between genetic polymorphisms of inflammatory cytokines, CRP levels and periodontitis
  Hanai Y, Sugita N, Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  EuroPerio 8, London, 03 Jun. 2015
• Variants in uncoupling protein genes associated with severe periodontitis in postmenopausal Japanese women
  Sugita N, Yoshihara A, Hanai Y, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  EuroPerio 8, London, 03 Jun. 2015
• 歯肉上皮細胞におけるADAM17とTNF-αの関係について
  村野綾, 粟野秀慈, 岩崎正則, 邵仁浩, 安細敏弘
  第64回日本口腔衛生学会・総会, つくば市, 27 May 2015
• PDMS/ZSM-5複合薄膜-GC-MS法による唾液分析と疾患診断の可能性
  茂山博代, 岩崎正則, 邵仁浩, 粟野秀慈, 安細敏弘
  第64回日本口腔衛生学会・総会, つくば市, 27 May 2015
• Association between Periodontitis and Cardiovascular Disease-Related Medical Expenditure
  Sato M, Iwasaki M, Yoshihara A, Miyazaki H.
  第64回日本口腔衛生学会・総会, つくば市, 27 May 2015
• 介護施設利用高齢者における簡易嚥下状態評価（EAT-10）と口腔内・栄養・嚥下状態との関連
  秋山理加, 濱嵜朋子, 岩崎正則, 邵仁浩, 山田志麻, 酒井理恵, 巴美樹, 粟野秀慈, 安細敏弘
  第64回日本口腔衛生学会・総会, つくば市, 27 May 2015
• 在宅高齢者における簡易嚥下状態評価（EAT-10）と栄養状態および栄養素摂取との関連
  濱嵜朋子, 広富敏伸, 秋山理加, 岩崎正則, 邵仁浩, 粟野秀慈, 山田志麻, 巴美樹, 葭原明弘, 宮崎秀夫, 安細敏弘
  第64回日本口腔衛生学会・総会, つくば市, 27 May 2015
• The effects of periodontal disease on diabetes-related medical expenditure
  Sato M, Iwasaki M, Yoshihara A, Miyazaki H.
  IADR/AADR/CADR General Session & Exhibition - Boston, Massachusetts, 11 Mar. 2015
• 〔Major achievements〕Association between oral health status and cognitive function among older Japanese
  Iwasaki M, Taylor GW, Sato M, Ogawa H, Yoshihara A, Yamaga T, Kimura Y, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Chen W, Imai H, Fujisawa M, Okumiya K, Otsuka K, Miyazaki H, Matsubayashi K.
  IADR/AADR/CADR General Session & Exhibition - Boston, MA, U.S., 11 Mar. 2015
• 高齢者における歯周病が医療費に及ぼす影響
  佐藤美寿々, 岩崎正則, 葭原明弘, 宮崎秀夫
  第47回新潟歯学会総会, 新潟市, 19 Apr. 2014
• Effects of periodontal disease on medical expenditures in elderly people
  Sato M, Iwasaki M, Yoshihara A, Miyazaki H.
  The 10th World Congress on Preventive Dentistry, Budapest, Hungary, 09 Oct. 2013
• フッ化物洗口の有効性と安全性について
  岩崎正則
  わかりやすいフッ化物応用講座～フッ化物洗口の実際～, 新潟市, 10 May 2013
  [Invited]
• フッ化物応用の有効性と安全性について
  岩崎正則
  歯科専門職のためのフッ化物応用セミナー, 長岡市, 28 Mar. 2013
  [Invited]
• The Relationship Between Metabolic Syndrome and Periodontitis Among Older Japanese
  Minagawa K, Iwasaki M, Ogawa H, Yoshihara A, Miyazaki H.
  IADR/AADR/CADR General Session & Exhibition - Seattle, WAS, U.S., 20 Mar. 2013
• 〔Major achievements〕Oral Health Status: Nutrient and Food Intakes among Older Japanese
  Iwasaki M, Taylor GW, Manz MC, Yoshihara A, Muramatsu K, Watanabe R, Miyazaki H.
  IADR/AADR/CADR General Session & Exhibition - Seattle, WAS, U.S., 20 Mar. 2013
• The relationship between metabolic syndrome and periodontitis in the very old
  Minagawa K, Iwasaki M, Ogawa H, Yoshihara A, Miyazaki H.
  International Symposium on Human Resource Development towards Global Initiative, Thailand, 16 Feb. 2013
• CRP level in postmenopausal women with PPARγ polymorphism and periodontitis
  Wang Y, Sugita N, Yoshihara A, Iwasaki M, Miyazaki H, Nakamura K, Yoshie H.
  第60回国際歯科研究学会日本部会（JADR）総会・学術大会, 新潟市, 14 Dec. 2012
• Molecular biological factors in drug-induced gingival overgrowth
  Shimizu T, Kubota T, Iwasaki M, Morozumi T, Nakasone N, Yoshie H.
  American Academy of Periodontology (AAP), Los Angeles, CA, U.S., 29 Sep. 2012
• 〔Major achievements〕Two-year cohort study for the association between dietary antioxidants and periodontal disease in community-based older Japanese
  Iwasaki M; Moynihan P; Manz MC; Taylor GW; Yoshihara A; Muramatsu K; Watanabe R; Miyazaki H
  International Academy on Nutrition and Aging (IANA), NM, U.S., 12 Jul. 2012
• 地域在住高齢者におけるメタボリックシンドロームと歯周病の関連
  坂入久美子, 岩崎正則, 小川祐司, 葭原明弘, 宮崎秀夫
  第61回日本口腔衛生学会・総会, 横須賀市, 25 May 2012
• 地域在住高齢者におけるメタボリックシンドロームと歯周病の関連
  坂入久美子, 岩崎正則, 小川祐司, 葭原明弘, 宮崎秀夫
  第45回新潟歯学会総会, 新潟市, 16 Apr. 2012
• 〔Major achievements〕Effect of n-6 to n-3 polyunsaturated fatty acids ratio on periodontal health: 3-year follow up study
  Iwasaki M; Taylor GW; Moynihan P; Yoshihara A; Muramatsu K; Watanabe R; Miyazaki H
  第58回 国際歯科研究学会日本部会（JADR）総会・学術大会, 北九州市, 20 Nov. 2010
• Periodontal disease may affect kidney function in a community-based Japanese older population
  Iwasaki M; Yoshihara A; Miyazaki H
  第59回日本口腔衛生学会・総会, 06 Oct. 2010
• 保育園児に対する口腔周囲機能向上の取り組み
  坂口真弓, 葭原明弘, 岩崎正則, 田村卓也, 土屋信人, 佐藤徹, 宮﨑秀夫
  口腔衛生学会甲信越・北陸地方会, 新潟市, 25 Jul. 2009
• 簡易自己式食事歴質問票BDHQによる高齢者の栄養摂取状況と食事摂取状況との関連
  岩﨑正則; 葭原明弘; 宮﨑秀夫
  第20回日本口腔衛生学会甲信越北陸地方会総会, 25 Jul. 2009
• Longitudinal relationship between dietary docosahexaenoic acid and the dental condition
  Iwasaki M; Yoshihara A; Moynihan P; Watanabe R; Miyazaki H
  87th General Session & Exhibition of the IADR, 01 Apr. 2009
• Longitudinal relationship between dietary docosahexaenoic acid and periodontal disease
  Iwasaki M; Yoshihara A; Moynihan P; Watanabe R; Taylor GW; Miyazaki H
  University of Michigan School of Dentistry Research Day, 10 Feb. 2009
• フッ素洗口の有効性と安全性について
  岩﨑正則
  フッ素洗口学習会, 16 Sep. 2008
• 血清アルブミンと歯周病の関係についての経年的評価
  岩崎正則; 葭原明弘; 廣冨敏伸; 小川祐司; 花田信弘; 宮﨑秀夫
  第41回新潟歯学会総会, 26 Apr. 2008
• 栄養とお口の健康状態
  岩崎正則
  高齢者講演会, 新潟市, 24 Apr. 2008
  [Invited]

• 発表・論文執筆法演習Ⅰ, 2024年, 博士後期課程, 歯学院
• 発表・論文執筆法演習Ⅱ, 2024年, 博士後期課程, 歯学院
• 発表・論文執筆法演習Ⅲ, 2024年, 博士後期課程, 歯学院
• 予防歯科学, 2024年, 博士後期課程, 歯学院
• 予防歯科学研究Ⅰ, 2024年, 博士後期課程, 歯学院
• 予防歯科学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅰ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅲ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅳ, 2024年, 博士後期課程, 歯学院
• 口腔健康科学実習Ⅴ, 2024年, 博士後期課程, 歯学院
• 基本技法, 2024年, 博士後期課程, 歯学院
• 社会口腔保健学, 2024年, 博士後期課程, 歯学院
• 社会口腔保健学研究Ⅰ, 2024年, 博士後期課程, 歯学院
• 社会口腔保健学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 歯科学概論Ⅰ, 2024年, 学士課程, 歯学部
• 食の科学, 2024年, 学士課程, 歯学部
• 衛生公衆衛生学・予防歯科学Ⅰ, 2024年, 学士課程, 歯学部
• 衛生公衆衛生学・予防歯科学Ⅱ, 2024年, 学士課程, 歯学部
• 衛生公衆衛生学・予防歯科学基礎実習, 2024年, 学士課程, 歯学部
• 予防歯科学臨床実習Ⅰ, 2024年, 学士課程, 歯学部
• 予防歯科学臨床実習Ⅱ, 2024年, 学士課程, 歯学部
• 社会歯科学, 2024年, 学士課程, 歯学部
• 健康と社会, 2024年, 学士課程, 全学教育

• 2025 - Present
  日本産業衛生学会
• 2020 - Present
  日本補綴歯科学会
• 2019 - Present
  日本サルコペニア・フレイル学会
• 2019 - Present
  日本公衆衛生学会
• 2015 - Present
  日本歯周病学会
• 2015 - Present
  日本老年医学会
• 2015 - Present
  IADR
• Dec. 2014 - Present
  日本老年歯科医学会
• Oct. 2014 - Present
  日本疫学会
• Apr. 2008 - Present
  日本口腔衛生学会

• The role of commensality, oral function, and conversation in disability prevention: a comparative study of Thailand and Japan
  Grants-in-Aid for Scientific Research
  01 Apr. 2025 - 31 Mar. 2030
  木村 友美; 岩崎 正則; 角田 聡子; 石本 恭子; 依田 健志; 寺村 晃
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Tsuda University, 25K03358
• Verification of the effect of oral frailty countermeasures on healthy life expectancy through collaboration between medical care, health, and nursing care prevention
  Grants-in-Aid for Scientific Research
  Apr. 2025 - Mar. 2030
  渡邊 裕; 飯島 勝矢; 平野 浩彦; 白部 麻樹; 池邉 一典; 岩崎 正則
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 25K02834
• 歯周病がサルコペニア発症に与える影響の解明とリスクエンジンの開発：国際共同研究
  科学研究費助成事業
  Apr. 2025 - Mar. 2029
  岩崎 正則; 平野 浩彦; 吉田 明弘; 中村 純也; 佐藤 美寿々; 小川 祐司
  日本学術振興会, 基盤研究(B), 北海道大学, 25K02833
• 血液透析患者の唾液分泌促進を目指した患者参加型口腔ケアプログラムの開発
  科学研究費助成事業
  01 Apr. 2024 - 31 Mar. 2028
  古庄 夏香; 粟野 秀慈; 岩崎 正則; 前田 ひとみ
  日本学術振興会, 基盤研究(C), 下関市立大学, 24K13657
• Development of a method for seamless Oral function management for middle-aged and older adults
  Grants-in-Aid for Scientific Research
  Apr. 2025 - Mar. 2028
  白部 麻樹; 平野 浩彦; 岩崎 正則; 五十嵐 憲太郎
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Tokyo Metropolitan Institute for Geriatrics and Gerontology, 25K00348
• 糖尿病性腎症の改善のための口腔健康プログラムの構築
  科学研究費助成事業
  Apr. 2024 - Mar. 2027
  村岡 宏祐; 粟野 秀慈; 園木 一男; 守下 昌輝; 角田 聡子; 安細 敏弘; 岩崎 正則; 大田 祐子; 福原 正代; 山口 紫乃; 中村 太志
  日本学術振興会, 基盤研究(C), 九州歯科大学, 24K13246
• 口腔機能とサルコペニアを基軸としたベイジアンネットワーク解析による認知症予防戦略
  科学研究費助成事業
  Apr. 2024 - Mar. 2027
  細川 隆司; 近藤 祐介; 平野 浩彦; 笛木 賢治; 正木 千尋; 岩崎 正則
  日本学術振興会, 基盤研究(B), 九州歯科大学, 24K02635
• Systematic Research on a New Elderly-Centered View of Care Prevention.
  Grants-in-Aid for Scientific Research
  Apr. 2023 - Mar. 2027
  石本 恭子; 木村 友美; 依田 健志; 渡辺 長; 岩崎 正則
  本研究の目的は、生活環境が異なる４地域の高齢者を対象とする。異なる地域を比較検討することで、生活機能、心理的側面、社会的背景を踏まえた高齢者主体の介護予防観を示し、さらに身体機能の変化をとらえ介護予防観を系統的探究することである。
  有料老人ホーム居住している高齢者を11名を対象に、インタビュー調査を行った。「介護予防」について、認識している高齢者は、日ごろから運動や散歩など意識して体を動かすようにしていると回答が得られた。一方で、毎日の日常生活動作が「介護予防」であると認識している人もおられた。「介護予防」について認識していない高齢者は、80代と高齢であることが特徴であった。
  タイ、チェンマイにおいて、日常生活機能が低下してない８名の日本人高齢者にインタビューを行った。「介護予防」をタイで行っているという意見、特に何もしていないという意見もあった。「介護予防」よりも、帰国時に介護が必要になった時の対応についての関心を持つ方が多かった。
  タイ、ナコムパトムに住むタイ人高齢者には、「介護予防」という言葉が浸透していない現状であった。地域によっては、高齢者のための運動教室などが行われていた。
  個人、地域によって「介護予防」に対する考えは、異なっていた。有料老人ホームにおいては、介護予防体操教室などが行われており、「介護予防」という言葉を耳にする機会が多い。一方、タイでは介護予防活動に参加する機会は少ない。このような生活環境の違いが「介護予防」の認識に違いを生じていることが考えられた。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kawasaki University of Medical Welfare, 23K10309
• 高齢者の口腔機能低下から摂食嚥下機能障害の包括的評価システム考案に関する調査研究
  科学研究費助成事業
  01 Apr. 2024 - 31 Mar. 2026
  平野 浩彦; 山本 敏之; 福本 裕; 岩崎 正則; 有阪 直哉; 本川 佳子; 枝広 あや子
  本研究では、地域在住高齢者および要介護高齢者（神経筋疾患患者、認知症患者含む）を対象とし、口腔機能低下から摂食嚥下機能低下への変遷、およびそれに伴い生じるリスクの把握を行う。さらに、一連の機能低下進行に沿った系統立った支援・対応策を検討するための「高齢期口腔機能および摂食嚥下機能の包括的評価システム」の考案を最終的な目標としている。本年度は、各調査フィールドにおける調査の実施およびデータベースの構築を行った。
  ①地域在住高齢者を対象とした調査結果
  高齢期のほか、壮年期も対象に調査を行い、年代別の口腔機能低下の様相について検討を行った。対象は677名（男性290名、女性387名）で、40歳代が51名、50歳代が66名、60歳代が168名、70歳代が271名、80歳代が121名であった。口腔機能低下症の有病率は、40歳代で5.9％、50歳代で10.6％、60歳代で16.7％、70歳代で26.2％、80歳代で47.9％であり、加齢とともに上昇する傾向を示した。また口腔機能低下症の下位症状の各項目においては、加齢とともにTCI（Tongue Coating Index）およびEAT-10の値は増加し、咬合力、ODK（オーラルディアドコキネシス）、舌圧、およびグミスコアの値は低下する傾向を示した。
  ②神経筋疾患患者を対象とした調査結果
  対象は、74名（男性37名、女性37名、平均58.3±18.1歳）であった。主病名は、パーキンソン病（20.3％）、筋ジストロフィー（18.9％）、多系統萎縮症（13.5％）の順に多かった。また口腔機能低下症の基準に該当する各下位症状の項目の割合は、ODK（78.9％）、舌圧（55.4％）、TCI（50.0％）の順に高かった。さらにVF検査を行った結果、誤嚥（14.9％）、喉頭蓋谷の残留（36.5％）、梨状陥凹の残留（25.7％）の所見を認めた。
  日本学術振興会, 基盤研究(B), 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 23K27811
• Effect of intensified treatment with urate-lowering drugs on periodontal disease
  Grants-in-Aid for Scientific Research
  01 Apr. 2023 - 31 Mar. 2026
  大田 祐子; 福原 正代; 土橋 卓也; 岩崎 正則; 藤澤 律子; 井上 真紀
  歯周病は生活習慣病として位置づけられており、歯周病による全身性の炎症応答の亢進が血管障害の発症および進行に関与するだけでなく、糖尿病や慢性腎臓病が歯周病に影響を及ぼすという双方向の関連性が報告されている。一方で、我が国で増加傾向にある高尿酸血症は炎症性サイトカインや酸化ストレスを介して血管内皮障害の惹起と動脈硬化の進展に関与することが数多く報告されているものの、高尿酸血症と歯周病との関連性に関しては未だ一定の見解がない。また、高尿酸血症・痛風の治療ガイドラインでは、高尿酸血症患者の血清尿酸値を6.0 mg/dL以下に維持することが推奨されているものの、尿酸降下薬内服者におけるその達成率は低いことが報告されている。本研究課題では、日本人の高尿酸血症患者を対象とし、異なる作用機序を有する尿酸降下薬による治療強化が歯周病に与える影響を検討する。尿酸値の低下が歯周病を改善するのか、あるいは尿酸の低下度に関わらずキサンチンオキシダーゼ阻害が歯周病の改善に関連するのかを検討することにより高尿酸血症と歯周病の関連機序が明らかになると思われる。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kyushu Dental College, 23K09464
• 高齢者の口腔機能低下から摂食嚥下機能障害の包括的評価システム考案に関する調査研究
  科学研究費助成事業
  Apr. 2023 - Mar. 2026
  平野 浩彦; 山本 敏之; 福本 裕; 岩崎 正則; 有阪 直哉; 本川 佳子; 枝広 あや子
  日本学術振興会, 基盤研究(B), 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 23H03121
• 口腔機能と終末糖化産物に焦点を当てた時間生物学的アプローチによる認知症予防戦略
  科学研究費助成事業
  Apr. 2023 - Mar. 2026
  正木 千尋; 近藤 祐介; 平野 浩彦; 細川 隆司; 岩崎 正則
  歯を喪失すると咀嚼能力の低下による脳血流量の低下や栄養状態の悪化が生じ、認知症のリスクが上昇することが複数のコホート研究を集めたメタ分析で示されている。一方、近年、体内に蓄積する終末糖化産物であるadvanced glycation end products (AGEs) が注目されており、AGEsなど糖化がアミロイドβの凝集や沈着を促進させ、アルツハイマー型認知症の独立したリスク因子であることが明らかにされた。そのため、経年的なAGEsの蓄積量が口腔機能と認知機能との関連における交絡因子である可能性があるものの、その影響については全く分かっていない。そこで本研究は東京都での大規模コホート（お達者研究）と協働し、咀嚼能力などの口腔機能やAGEsの蓄積を含めた認知機能低下のリスク因子について検討することを目的とした。
  本年度は東京都板橋区の地域在住65歳以上の高齢者584名を対象とし、口腔機能に関するベースライン調査（現在歯、補綴の状況、残存歯数、機能歯数、咀嚼能力、咬合力、歯周組織検査）、AGEs量の測定（皮膚蛍光法）、などを行った。現在歯数や口腔機能低下症7項目（オーラルディアドコキネシス、口腔湿潤度、咬合力、咀嚼機能、嚥下機能など）の基準値で2値化し、AGEs量とマンホイットニーU検定による2群比較を行ったところ、現在歯数（20本以上/未満）およびオーラルディアドコキネシス（全て6.0回/s以上/いずれか6.0回/s未満）においてAGEs量に有意な相違が見られることが示唆された。
  日本学術振興会, 基盤研究(C), 九州歯科大学, 23K09299
• Study on integrated implementation of public health service and care prevention for the elderly regarding oral frailty
  Grants-in-Aid for Scientific Research
  01 Apr. 2024 - 31 Mar. 2025
  渡邊 裕; 飯島 勝矢; 小原 由紀; 平野 浩彦; 池邉 一典; 岩崎 正則
  ①オーラルフレイルの有病率と低栄養、要介護等の発生要因に関する調査
  2023年度は2022年度に行われた口腔機能に関連する大規模長期コホート研究（板橋）、後期高齢者歯科健診（鳥取県）のデータを2018～2021年のデータと統合し、それぞれ1,517名、5,215名のデータベースを構築した。後期高齢者歯科健診と国保データベースの統合研究では、オーラルフレイルと医療費との関連について論文化した。また、オーラルフレイルと食欲、食品摂取の多様性について分析し、オーラルフレイルと食、食品摂取の多様のほか、年齢、性別、簡易フレイル指数、服薬数に有意な関連があることを明らかにした。さらに本年度から愛知県後期高齢者医療制度加入者の2020年1,039,830名と2021年1,069,381名のデータベースを取得分析し、口腔に問題がある者、歯科受診がなかった者を集計した。
  ②地域包括ケアシステムにおける住民主体の通いの場と歯科診療所との共同によるオーラルフレイル予防のための地域介入研究、③オーラルフレイル改善プログラムの効果検証
  岩見沢市でのオーラルフレイル予防のための地域介入研究は感染対策のため、地域在住高齢者400名に対して保健センターとオンラインでオーラルフレイル改善プログラムを実施した。2022年、2023年の参加者の分析では、半年間のオーラルフレイル改善プログラムによって、77.3％が維持改善していた。以上の結果からオーラルフレイル改善プログラムによる改善効果が期待された。海老名市では848名に対して歯科診療所でオーラルフレイル改善プログラムを実施し、介入前後の比較を行った。また、国保データベースとの突合を行い３年間の総医療費がオーラルフレイル該当者は非該当者よりも有意に高く、3年間の要介護の発生と重度化のリスクが2倍以上高くなることを明らかにした。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 23K20334
• 多歯時代の歯周病：機械学習による将来予測とスクリーニングスコアの開発
  科学研究費助成事業
  01 Apr. 2022 - 31 Mar. 2025
  岩崎 正則; 平野 浩彦; 福田 英輝
  多くの歯が残るようになった高齢者世代での歯周病有病率の上昇が顕著である。しかし高齢者歯周病対策への人的・物的資源の割当の指針となる有病率の将来推計は存在しない。また歯周病疫学研究の国際的ゴールドスタンダードは6点法プロービングであるものの、その実施困難さが高齢期歯周病疫学研究の進展を妨げている。
  本研究では65歳以上高齢者約2,500人からなる国内最大規模の歯周病データベースを構築する。これを基盤として、機械学習を利用し、多くの特徴量を組み合わせた大規模・高次元データ解析を行うことで、高齢者歯周病対策の立案と高齢期歯周病疫学研究の進展・エビデンスの創出に資する知見を生み出すことを目指す。具体的な目的として以下の2つを設定した。
  目的①65歳以上高齢者人口がピークとなる2040年までの高齢者歯周病有病率の将来推計
  目的②申請者が開発した日本語版歯周健康状態評価質問紙をベースとした、プロービングによらない高齢期歯周病スクリーニングスコアの開発
  研究初年度である2022年度には新たな研究対象集団の決定と、リクルートおよびデータ採得の準備を行った。あわせて、既存のデータを用いて日本語版歯周健康状態評価質問紙の高齢者における妥当性評価を行った。結果の一部を第65回秋季日本歯周病学会学術大会にて発表した（岩崎ほか, 2022, 地域在住高齢者におけるCDC・AAP歯周病質問票日本語版の妥当性の検討：お達者健診研究）。現在、論文化に向けて研究を進めている。
  日本学術振興会, 基盤研究(C), 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 22K10331
• A Study on Integrated Implementation of Health Service and Preventive Long-Term Care Service for the Elderly Regarding Oral Frailty
  Grants-in-Aid for Scientific Research
  Apr. 2020 - Mar. 2025
  渡邊 裕; 飯島 勝矢; 小原 由紀; 平野 浩彦; 池邉 一典; 岩崎 正則
  ①オーラルフレイルの有病率と低栄養、要介護等の発生要因に関する調査
  2021年度は2020年度に行われた口腔機能に関連する大規模長期コホート研究（板橋）、後期高齢者歯科健診（神奈川県、鳥取県）のデータを2018年、2019年のデータと統合した。2021年度は草津、高島平の調査と、介入研究（岩見沢）はCOVID-19のため実施できなかった。2018年から2020年までに実施された、板橋、草津、高島平、柏の統合データを用いて、地域在住の日本人高齢者5,083人の舌圧の年齢別および性別別の人口基準値を算出した。結果、男女ともに、高齢になるほど舌圧は有意に減少した。年齢と性別の相互作用は、舌圧に有意な影響を及ぼしていることが明らかになった。これについては論文化し公開した。オーラルフレイルと医療費との関連については、2190名の後期高齢者歯科検診のデータと国保データベースを統合し分析した。結果、オーラルフレイルは医科の年間外来医療費が高額であることと有意な関連を認めた。同様に歯科の年間外来医療費とオーラルフレイルにも有意な関連を認めた。オーラルフレイルの各検査項目と医療費との関連については，客観的咀嚼能力の低下と医科の年間外来医療費が高額であることと有意な関連を認めた。
  ②地域包括ケアシステムにおける住民主体の通いの場と歯科診療所との共同によるオーラルフレイル予防のための地域介入研究、③オーラルフレイル改善プログラムの効果検証
  令和２年度と同様に海老名市では歯科診療所において、岩見沢市では通いの場においてオーラルフレイル改善プログラムを実施する予定であったが、岩見沢市では通いの場がCOVID-19によって自粛となり、自宅でのセルフプログラムでの実施となった。海老名市では予定通りオーラルフレイル改善プログラムを実施し、効果について国保データベースと統合し分析している。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 20H03899
• ベイジアンネットワークによる口腔機能低下リスクの解明とフレイル予防戦略の構築
  科学研究費助成事業
  01 Apr. 2021 - 31 Mar. 2024
  細川 隆司; 近藤 祐介; 木村 友美; 野代 知孝; 坂本 龍太; 宗政 翔; 向坊 太郎; 正木 千尋; 角田 聡子; 安細 敏弘; 岩崎 正則
  歯の支持に関連する指標として，歯根膜を介して歯槽骨と結合している歯根表面積の個人ごとの和(以下 RSA-PL)を算出し，RSA-PLがオーラルフレイルの評価における咀嚼能力・咬合力と関連するか検討した.
  土佐町フィールド医学研究に参加した地域在住高齢者250名(平均年齢82.5歳，男性98名，女性152名)を本研究の対象とした.咀嚼能力評価には咀嚼チェックガムを用い測色計を用いてa*値を指標として評価した，咬合力は，デンタルプレスケールIIおよびバイトフォースアナライザを用いて計測した．また，全顎6点法でのPPD，CALを測定し，各歯の付着の喪失の総面積(以下ALSA)を算出した.先行研究で報告されている各歯の歯根表面積(RSA)からALSAを減ずることで，RSA-PLを算出した. a*値と咬合力のそれぞれを目的変数とし，RSA-PL を主要な説明変数とする単変量・多変量線形回帰分析を実施し，RSA-PLがa*値と咬合力に与える影響を評価した.また，平均PPD，平均CALがa*値と咬合力に与える影響を別途評価した.
  解析の結果，研究対象集団におけるRSA-PLの平均値(標準偏差)は26.3(22.3)cm2であった.年齢，性別，定期歯科受診状況，喫煙状況，身体活動レベル，BMI，抑うつ，脳梗塞の既往，および糖尿病で調整した後も RSA-PLはa*値と咬合力とそれぞれ有意に関連していた(RSA-PL 1cm2増加毎のa*値に対する調整済回帰係数[95%信頼区間]= 0.16 [0.1 to 0.22];咬合力に対する調整済回帰係数[95%信頼区間]= 9.2 [5.3 to 13.1]).一方，平均PPD，平均CALはa*値と咬合力と関連していなかった.
  これらの結果から，RSA-PLはオーラルフレイルを評価する上で優れた指標であることが示唆された.
  日本学術振興会, 基盤研究(B), 九州歯科大学, 21H03134
• Developing community-based programs for frailty in elderly people: an action research on primary care interventions in Thailand and Japan
  Grants-in-Aid for Scientific Research
  01 Apr. 2019 - 31 Mar. 2024
  Kimura Yumi
  This study aimed to explore “frailty” among older adults by the multi-disciplinal research approach and to develop a community-based model of Kaigo-yobo (prevention of being dependent and in need of long-term care) in Thailand and Japan. Although the research plan had to be modified from the original form due to the COVID-19 pandemic, we were able to conduct a survey focusing on the health status and preventive behaviors of the elderly during and after the pandemic, and succeeded to publish the academic results more than expected. On the other hand, the intervention study could not be fully implemented due to the difficulty of conducting interventions targeting a older population due to the infection control, thus individual exercise guidance and health counseling were conducted with local medical staffs in addition to on-site surveys.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Osaka University, 19H04352
• Research on the Relationship between Oral Frailty and Intestinal Microflora in Older Adults
  Grants-in-Aid for Scientific Research
  Apr. 2021 - Mar. 2024
  Ohara Yuki
  Analysis of data from 102 community-dwelling older participants showed that the oral frailty group, which had a combined decline in oral function, had a significantly lower component of the Bacteroidota than the group without oral frailty. The results of multiple regression analysis also showed that the presence of oral frailty was significantly associated with a lower component of the Bacteroidota (β = -2.62, 95% confidence interval -6.2 to -0.86). Our results indicate that in old age, poor oral function may contribute to the composition of the Bacteroidota, which is the most dominant group of intestinal bacteria and is thought to influence intestinal immunity.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 21K10224
• Study on Oral and Swallowing Function in the Elderly and the Design of a Comprehensive Evaluation System
  Grants-in-Aid for Scientific Research
  01 Apr. 2020 - 31 Mar. 2023
  Hirano Hirohiko
  The following two surveys were conducted to clarify the disease structure of oral hypofunction in old age and to construct basic data for its management. (1) Identification of the actual condition of oral and feeding/swallowing hypofunction: An integrated database of 2,503 elderly people (average age 77.0 years; 1,615 women) living in the community was created. (2) Identification of risks associated with oral and feeding and swallowing functional decline: A model of oral hypofunction was reconstructed in order of intensity of association with outcomes, and a four-item model of low tongue pressure, poor masticatory function, poor lingual-lip motor function, and poor bite strength was identified as a candidate model.
  In conclusion, the four-item model is comparable to the current seven-item assessment in terms of outcome discrimination, and will also enable the definition of the severity of oral hypofunction.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 20H03903
• Development of an oral care program to promote saliva secretion and to improve oral hygiene in elderly hemodialysis patients
  Grants-in-Aid for Scientific Research
  01 Apr. 2019 - 31 Mar. 2023
  Furusho Natsuka
  In a fact-finding survey, we investigated intraoral and nutritional-related data and health-related QOL prior to intervention. Both oral-mucosa-fluid volume and awareness of dry mouth were low, indicating drier than average oral conditions. It was also revealed that the nutritional status and health-related QOL were low. After the fact-finding survey, we aimed to develop a program to promote saliva secretion. Our oral-care program was designed to be easily completed within the standard dialysis time used by medical professionals.
  Results from the intervention demonstrated improvements in dry-mouth sensation and nutritional-related data; an amelioration of mouth hemorrhages and oral inflammation; a decrease in the oral-bacterial count; reductions in fluid intake due to improvement of dry mouth, and a tendency to find eating easier. Additionally, positive changes in patient awareness and subsequent behavioral modifications for oral-care among patients were revealed.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), 福岡県立大学, 19K10777
• Development of an oral health program for the prevention of diabetic nephropathy
  Grants-in-Aid for Scientific Research
  01 Apr. 2019 - 31 Mar. 2023
  村岡 宏祐; 角田 聡子; 守下 昌輝; 岩崎 正則; 園木 一男; 福原 正代; 安細 敏弘; 粟野 秀慈
  生活習慣病の一つで患者数が増加の一途を辿っており，患者数が多い疾患が糖尿病である。糖尿病の合併症の一つである糖尿病性腎症がある。血液透析導入の主要な原因疾患は糖尿病の一つである糖尿病性腎症である。糖尿病性腎症の重症化の予防は，患者の口腔内状態，全身状態の維持や医療費削減にも繋がり最も重要な課題となっている。
  本研究の目的は，糖尿病患者ならびに糖尿病性腎症の患者の口腔健康状態の問題点を抽出し，問題点を図ることにより，最終的には糖尿病性腎症重症化予防プログラムの構築をすることである。
  被験者は人工透析を行っている143名を解析した。口腔健康調査項目として，口腔状態，歯周ポケット，クリニカルアタッチメントレベル，歯肉からの出血などを測定した。全身健康調査として，血中ののADLH2遺伝子多型，IL-6遺伝子多型を測定した。ADLH2遺伝子多型，IL-6遺伝子多型の有無と口腔内，全状態を評価した。両パラメーターに有意に関与する因子はクレアチニンフォスフォキナーゼ（CPK）であった。本結果から歯周組織の程度によりCPKが影響し，このCPKが心機能に影響を及ぼすことを示唆した。
  本解析により人工透析患者における口腔内状態と全身状態のサイクルについて考察することが可能になった。このことから，人工透析患者の重症化予防のプログラムの構築することが可能と考える。しかしながら解析中の被験者もいるため，今後詳細に解析，検討を行う予定である。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kyushu Dental College, 19K10468
• 唾液バイオマーカーを用いた社会的フレイル評価法とコミュニティー支援システムの構築
  科学研究費助成事業
  01 Apr. 2019 - 31 Mar. 2023
  角田 聡子; 安細 敏弘; 岩崎 正則; 邵 仁浩; 福原 正代; 濱嵜 朋子
  本研究の目的は大きく次の3つである。①社会的フレイルを唾液を用いて評価すること。②社会的フレイルと身体的フレイル(オーラルフレイル)の関連について調べること。③フレイル予測、予防・介入方法を立案することである。 フレイルの評価方法の標準化と社会的フレイルの客観的評価、さらにそれぞれのフレイルの 相互の影響を判断することでフレイルのリスク診断が可能になると考える。得られたデータを基に、調査期間中の体内組成の変化や口腔・栄養状態の変化、死亡や発症に伴う要介護認定の関連について解析することでフレイルリスク診断、予防プログラム を作成するのが大きな目的である。
  本年度は研究全期間4年中3年目であり、本年度中に最終調査を行う予定であったが、Covid-19の影響により、大規模な集団調査を行うことは不可能であった。 そこで、これまでに収集したデータの解析を主に行い、国内学術学会および国際学術学会にて発表した。
  日本学術振興会, 基盤研究(C), 九州歯科大学, 19K10449
• Association between periodontal disease and cardiovascular diseases in haemodialysis patients: A 10-year cohort study.
  Grants-in-Aid for Scientific Research
  01 Apr. 2019 - 31 Mar. 2023
  大田 祐子; 福原 正代; 岩崎 正則; 粟野 秀慈; 安細 敏弘; 邵 仁浩; 角田 聡子
  日本人の血液透析患者を対象とした心血管病データベースを再構築した疫学研究の成績を用いて、心血管病発症とそれによる死亡を標的として、歯周病重症度および歯周病原細菌感染度との関連を評価し、歯周病が心腎連関進展へ与える影響についての検討を行っている。
  既往歴、家族歴、生活歴（飲酒・喫煙)、服薬状況（降圧薬、糖尿病治療薬など）、透析期間、透析基礎疾患の基本情報、身体計測（身長、体重、基準体重）、透析前後血圧、Kt/V（標準化透析量）、血液検査（血計、脂質、血糖など)の医科項目、残存歯数、歯冠・歯根の状態、咬合状態、歯周病罹患の有無、口臭、口腔粘膜、唾液検査（分泌量、pH）、縁下プラーク、 舌苔、唾液・プラーク・舌苔中の歯周病原性細菌の歯・口腔診査のデータベースの確認を行い、追跡調査として、本研究のエンドポイントである心血管病（心筋梗塞、狭心症、冠攣縮性狭心症、冠動脈バイパス術後、経皮的冠動脈形成術後、脳出 血、脳梗塞、くも膜下出血、心不全、心房細動、高血圧、その他の不整脈、大動脈瘤）発症と死亡のデータ収集中である（①近隣医療機関との緊密な連携のもと、心血管病発症や死亡の有無を定期的に調査する。②転院した者については、郵送・電話による アンケート調査を行い、心血管病発症や死亡の有無について調査する。上記①・②で心血管病が疑われた場合、および脂肪が確認された場合には、医療機関においてその診断に必要な臨床情報を系統的に収集し、心血管病の発症の有無を調査し、死亡の場合は死亡時の臨床情報と死亡 診断書により死因を確定する）。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kyushu Dental College, 19K10423
• Development of a frailty assessment index that includes psycho-social factors.
  Grants-in-Aid for Scientific Research
  01 Apr. 2019 - 31 Mar. 2023
  Ishimoto Yasuko
  We examined frailty-related factors in older residents of a private nursing home at one and two years. Depression scores were a frailty-related factor in both years. The results suggest that psychological factors were associated with frailty. The study also focused on one of the psychological factors, peace of mind behavior. A comparative study of older people living in a private nursing home in Japan and those community-dwelling in Thailand showed that living environment and lifestyle influenced peace of mind behavior. Furthermore, it was suggested that the continuance of peace of mind behavior may be related to the maintenance of basic activities of daily living. Attention to the psychological aspects of older people was necessary for the prevention of frailty.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kawasaki University of Medical Welfare, 19K11160
• The significance of the repetition saliva swallow test for predicting pneumonia death
  Grants-in-Aid for Scientific Research
  01 Apr. 2017 - 31 Mar. 2023
  Fukuhara Masayo
  In 1998，827 80-year-01d residents of Fukuoka Prefecture participated the dental and medical examination, which included the repetitive saliva swallowing test (RSST). The RSST is a safe and simple screening method for the swallowing function and evaluates how many times people can swallow in 30 seconds. Less than 3 cycles is considered as abnormal. We followed up 822, who completed the RSST, and investigated the association between dysphagia and mortality rate from pneumonia. For 12 years 504 died. Eighty-one died of pneumonia. Kaplan-Meier method showed the mortality rate from pneumonia was significantly higher in the subjects with dysphagia compared to the subjects without dysphagia (p<0.05)．In Cox proportional hazard model，dysphagia is a significant and independent risk factor for death of respiratory disease（hazard ratio 1.6）. The mortality rate from pneumonia was significantly higher in the subjects with dysphagia evaluated by RSST.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kyushu Dental College, 17K12017
• 成人期における口腔の健康と全身の健康の関係性の解明のための研究
  厚生労働科学研究費補助金 循環器疾患・糖尿病等生活習慣病対策総合 研究事業
  2021 - Mar. 2022
  小坂 健; 辻 一郎; 斎藤 武仁; 相田 潤; 岩崎 正則; 財津 崇; 大野 幸子
  厚生労働省, 21FA1301
• Role of gene polymorphisms in the association between periodontal disease and cardiovascular disease mortality risk among hemodialysis patients:
  Grants-in-Aid for Scientific Research
  Apr. 2018 - Mar. 2022
  Iwasaki Masanori
  The aim of this study is to investigate the role of gene polymorphisms in the association between periodontal disease and cardiovascular disease mortality risk among hemodialysis patients.
  We could not complete the study due to the coronavirus disease 2019 (COVID-19) pandemic. However, with the use of existing data of epidemiological study, we have demonstrated the association of periodontal disease with kidney function, vascular endothelial function, cognitive function, and health behavior.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), 18K09919
• Cohort study regarding association between oral and systemic health from chronobiology
  Grants-in-Aid for Scientific Research
  01 Apr. 2018 - 31 Mar. 2021
  Ansai Toshihiro
  Many problems have been pointed out regarding the environment surrounding workers in Japan. Although clock-biology-related factors such as shift work and social jet lag are thought to negatively affect oral and systemic health and psychological status, the detailed mechanisms are not clear. We conducted oral health condition and questionnaire survey of 540 employees and bus drivers (average age 47.9 years) to evaluate their oral and general health status, as well as their dietary and nutritional intake. Those with low occlusal strength tended to be insomniacs, suggesting that the intake of vitamin D and vitamin B12 may influence the findings through a mediating effect. Also, the intake of calcium, vitamin D, vitamin B2, and small fish was lower in those with low chewing ability. The number of teeth with periodontal pockets of 4 mm or more was significantly higher in those who ate one or more staple stacked meals per day than in those who ate less than one stacked meal per day.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Kyushu Dental College, 18H03016
• Development and validation of a rehabilitation nutrition program for improvement of oral sarcopenia
  Grants-in-Aid for Scientific Research
  Apr. 2016 - Mar. 2020
  KAKUTA SATOKO
  It is not fully understood that the relation between decline of total body muscles, weakened muscles (sarcopenia) and oral function, nutrition, and also that how they can be prevented or improved. In this study, we investigated the relationship between sarcopenia , oral function and nutrition.
  This study shows that it is related to total body muscle mass and oral muscle strength (tongue pressure: power of the tongue) in the elderly. It was also shown that the functions of tongue and swallowing (power for swallowing)may affect decline nutrient status and nutrient intake.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kyushu Dental College, 16K11868
• Frailty among the Elderly in Asia: A comprehensive study in Thailand and Japan
  Grants-in-Aid for Scientific Research
  Jul. 2016 - Mar. 2019
  Kimura Yumi
  The field survey had carried out in the community in Japan and Thailand and aim to reveal frailty with multiple aspects which include mental status such as depression and QOL, nutrition status, and social backgrounds, as well as physical functions. Frailty of the elderly in Nakhon Pathom in Thailand was associated with oral health status. However, the associations between frailty and other physical health status was not confirmed. The previous tool to screen “frailty” had introduced and studied in Western countries, and it is not confirmed if the tool is applicable to Asian communities or not. Through the quantitative interview to the elderly people, we found that the elderly in Thailand perceive “frailty” as a natural aging process. The keywords to express frailty for the elderly persons were connected with the words of “surroundings with people and society” and it’s not always stand for the physical strangeness or independence status.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Osaka University, 16KT0120
• Epidemiological study regarding association between aggresive periodontitis and the Mediterranean diet in the Moroccan population
  Grants-in-Aid for Scientific Research
  Apr. 2016 - Mar. 2019
  Ansai Toshihiro
  Our aim was to investigate a prevalence of aggressive periodontitis (AgP) and the association between AgP and the Mediterranean diet in the Moroccan population. Olive oil consumption score (a component of MDS) was significantly and inversely associated with AgP (adjusted odds ratio = 0.55, 95% confidence interval = 0.32-0.96). The dietary pattern characterized by frequent consumption of olive oil may have a protective effect against AgP. Further longitudinal studies with data on serum fatty acid composition are required to substantiate our findings.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Kyushu Dental College, 16H05851
• Clinical research on malnutrition prevention effect and prognosis focusing on nutrition management in perioperative period of oral cancer
  Grants-in-Aid for Scientific Research
  Apr. 2015 - Mar. 2019
  SAKAI RIE; BEPPU Megumi
  We recognized the importance of maintaining nutritional status from the survey of inpatients with oral cancer at the Dental University Hospital in 2012-2013. The purpose of this research is to examine the effects and prognosis of malnutrition prevention by professional nutrition management that secures appropriate energy amount and nutrients before and after surgery by the dentist and the registered dietitian in cooperation in 2017-2018.
  As a result, although there are more severe patients in the 2nd term than in the 1st stage, the weight loss rate and the number of hospital days do not differ from those in the 1st stage, and the energy and nutrients that are lacking due to collaboration between the dentist It is surmised that the importance of nutritional management such as supplementation by using nutritional agents and instructing patients on the importance of food at admission and discharge was recognized.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), 15K11439
• Analysis of pathologic subjective halitosis using psychological scales and development of clinical guideline for general practitioners
  Grants-in-Aid for Scientific Research
  Apr. 2016 - Mar. 2018
  Ansai Toshihiro
  Pathologic subjective halitosis is known as a halitosis complaint without objective confirmation of halitosis by others or by halitometer measurements; it has been reported to be associated with social anxiety disorder. However, causal relationship between pathological subjective halitosis and psychological variables remains unclear. Therefore, we investigated potential causal relationships among pathologic subjective halitosis, olfactory reference syndrome, social anxiety, and preoccupations with body part odors. A total of 1360 female students answered a self-administered questionnaire. Bayesian network analysis showed that social anxiety directly influenced pathologic subjective halitosis and olfactory reference syndrome. Preoccupations with mouth and body odors also influenced pathologic subjective halitosis. Social anxiety may be a causal factor of pathologic subjective halitosis and olfactory reference syndrome.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Kyushu Dental College, 16K15857
• Study of drug development targetting ADAMs in gingival epithelium for prevention of peridontal diseases
  Grants-in-Aid for Scientific Research
  Apr. 2015 - Mar. 2018
  Awano Shuji
  A disintegrin and metalloprotease 17 (ADAM17), one of proteases belonging ADAMs family, is a tumor necrosis factor (TNF)-converting enzyme that cleaves the prodomain of TNF-α, a proinflammatory cytokine that plays a central role in immune regulation and a variety of inflammatory responses in destructive periodontal disease. This study verified the possibility of ADAM17 in the gingival epithelium as a target for drug development to prevent periodontal diseases.
  Strong immunoreactivity for ADAM17 was observed in the epithelium of the inflamed gingival tissues and in in human oral keratinocytes (HOKs). Furthermore, treatment with either ADAM17 inhibitor or ADAM17 siRNA inhibited the generation of TNF-α induced by lipopolysaccharide (LPS) in HOKs. The present study demonstrates that ADAM17 is strongly expressed in the epithelium of gingival tissues and suggests that ADAM17 may be a key enzyme that regulates the generation of TNF-α in oral keratinocytes.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kyushu Dental College, 15K11424
• Bacteriological and immunological analysis for the regulatory factors of aggressive periodontitis in Morocco
  Grants-in-Aid for Scientific Research
  Apr. 2015 - Mar. 2018
  YOSHIDA Akihiro
  Aggressive periodontitis (AgP) is particular form of periodontitis which affects adolescent. However, oral microbiota of AgP has not been studied. In this study, salivary microbiota of the AgP and healthy subjects in Moroccan peoples were analyzed. This study includes 130 (AgP and Healthy, 65 each) university students in Morocco. Multiplex 16S rRNA (V3-V4) sequencing of bacterial DNA was performed. The significantly higher levels of Fimicutes, Bacillales, Streptococcaceae, Staphyrococcaceae families were detected in saliva from AgP subjects (P < 0.05). On the contrary, Proteobacteria, Gammaproteobacteria, Lactobacillaceae families were dominant in saliva from non-AgP subjects (P < 0.05). In genera levels, Bacilli, Streptococcus, Staphyrococcus are dominant in patients with AgP, while Lactobacillus, Porphyromonas are dominant in non-AgP subjects (P < 0.05, respectively). HOMD NGS analysis of saliva revealed the characteristic bacterial families/genera in patients with AgP.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Matsumoto Dental University, 15H05297
• Elucidation of social determinants of health associated with regional differences in caries prevalence among children : a multilevel analysis
  Grants-in-Aid for Scientific Research
  Apr. 2014 - Mar. 2018
  SOH INHO
  The purpose of this study was to identify regional differences in a prevalence of dental caries among children.The subjects were 3,243 children of one and a half or three years old, who participated in health checkups at Kitakyushu city. We examined a prevalence of dental caries among children of one and a half or three years old by administrative districts. Furthermore, we evaluated the relationship between a prevalence of caries at age of three and a lifestyle at the age of one and a half by administrative districts, employing logistic regression analysis. Then, we evaluated a prevalence of multiple dental caries among those who had one or more caries at the age of three as well.There were significant differences in a prevalence of multiple dental caries among those who had one or more caries at the age of three by administrative districts in Kitakyushu city. The odds ratio (95%CI) of multiple dental caries among children in C-district to A-district was 3.47 (1.47-8.23).
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kyushu Dental College, 26463170
• Investigating the effect of serum antibodies to periodontal bacteria on cardiorenal association
  Grants-in-Aid for Scientific Research
  Apr. 2014 - Mar. 2017
  Iwasaki Masanori
  Recent epidemiological study confirmed cardiorenal association. Periodontal disease is thought to play important role in cardiovascular and renal function. However, its effect on cardiorenal association has not been fully studied yet.
  We investigated the effect of serum antibodies to periodontal bacteria on cardiorenal association.
  Based on the results of epidemiological survey of community-based population and hemodialysis patient group, we confirmed that periodontal disease was significantly associated with renal and cardiovascular status. Future studies evaluating the potential effect of oral interventions for periodontal health improvement on cardiorenal function in these study population would be of great interest.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Kyushu Dental College, 26861827
• Molecular analyses of volatile organic metabolites identified from human odor and the association with cancer of head, neck and upper digestive organ
  Grants-in-Aid for Scientific Research
  Apr. 2013 - Mar. 2016
  Ansai Toshihiro; LEE SEUNGWOO; YOSHIDA AKIHIRO; TAKATA YUTAKA; IWASAKI MASANORI; SOH INHO; KAKUTA SATOKO; AWANO SHUJI; NAKAMICHI IKUO
  Disease diagnosis based on volatile organic compounds (VOCs) that are excreted from the human body is being realized in recent years. In this study, we report a novel method for analyzing VOCs present in healthy human saliva and urine via thin-film microextraction (TFME) coupled with gas chromatography-mass spectrometry (GC-MS). The VOC extraction was conducted with polydimethylsiloxane (PDMS) films hybridized with ZSM-5 that is one of aluminosilicate zeolites. The saliva and urine samples were collected from 8 healthy volunteers. Approximately 50 to 100 VOCs were obtained from the individual samples, among which 34 and 33 compounds were reproducible for the saliva and the urine samples, respectively. The current study based on TFME using PDMS/ZSM-5 hybrid films would provide a potential methodology for the sensitive analysis of VOCs or new biomarkers present at trace levels in biological samples.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Kyushu Dental College, 25293429
• The association between serum antibody to the periodontal pathogen and chronic kidney disease
  Grants-in-Aid for Scientific Research
  2011 - 2013
  IWASAKI Masanori
  Kidney disease is recognized as a global health problem; the estimated number of the people with chronic kidney disease (CKD) in Japan alone is 13.3 million, which represents 12.9% of the population. The aim of this study was to investigate the association between serum antibody to the periodontal pathogen and CKD in Japanese individuals. Data were available from 215 participants aged 79 yrs. We observed a significant association between elevated serum antibody titer to P. gingivalis and decreased kidney function, after controlling for other important health characteristics. The findings of the present study suggest that there is a significant association between elevated serum antibody titer to P. gingivalis and decreased kidney function in the community-based cohort of elderly Japanese. Future studies should evaluate the contribution of periodontal therapy in reducing the risk for the development or progression of CKD.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Niigata University, 23792504