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Kaneko Hirofumi

Faculty of Dental MedicineAssistant Professor

Researcher basic information

■ Degree
  • Doctor of Dental Surgery, Hokkaido University, Mar. 2025
■ URL
researchmap URLホームページURL■ Various IDs
Researcher number
  • 71019065
J-Global ID■ Research Keywords and Fields
Research Keyword
  • cetylpyridinium chloride
  • evaluation of shade integration
  • Resin Composite
Research Field
  • Life Science, Conservative dentistry
■ Educational Organization

Career

■ Career
Career
  • Apr. 2025 - Present
    Hokkaido University, Restorative Dentistry, Faculty of Dental Medicine, Assistant Professor, Japan
Educational Background
  • Apr. 2021 - Mar. 2025, Hokkaido University, 大学院歯学院, 博士課程口腔医学専攻, Japan
  • Apr. 2012 - Mar. 2019, Hokkaido University, School of Dental Medicine, Japan

Research activity information

■ Papers
  • Comprehensive Evaluation of Oral Diseases in Patients with Gastrointestinal Cancers: Epidemiological Evidence from a 10-Year Retrospective Study.
    Chiharu Kawamoto; Hirofumi Kaneko; Ryotaro Yago; Yudai Matsuo; Yuto Nakamura; Takuma Mirokuin; Shuhei Hoshika; Hidehiko Sano; Atsushi Tomokiyo; Naoya Sakamoto
    Cancers, 18, 12, 14 Jun. 2026, [Peer-reviewed], [International Magazine]
    English, Scientific journal, Background: The association between oral health and gastrointestinal (GI) cancers has been primarily investigated within a periodontitis-centered framework. However, the potential contribution of cumulative oral disease burden, including dental caries and apical pathology, remains insufficiently explored. The Decayed, Missing, and Filled Teeth (DMFT) index reflects lifetime exposure to oral microbial dysbiosis and chronic inflammation. Methods: This retrospective exploratory study included patients with GI cancers referred for perioperative oral screening and management at a tertiary care center between 2015 and 2025. Oral health was evaluated using the DMFT index, periodontal probing depth, and radiographically diagnosed apical periodontitis. Age-stratified DMFT and periodontal parameters were compared with national reference data, while apical periodontitis prevalence was descriptively assessed. Results: Patients with GI cancers demonstrated higher DMFT values than national averages across most adult age groups. The prevalence of periodontal pockets (≥4 mm and ≥6 mm) was also elevated. Apical periodontitis was common, affecting 46.3% of patients, with some age groups exceeding 50%. Overall, these findings indicate oral disease clustering with coexisting chronic oral conditions. Conclusions: Patients with GI cancers exhibit substantial oral disease burden, including increased caries experience, periodontal pathology, and apical lesions. These findings suggest that the oral-gastrointestinal cancer relationship may extend beyond a periodontitis-centered paradigm, and that cumulative oral disease burden-including cariogenic processes-may represent an underrecognized component of this axis. The DMFT index may serve as a surrogate marker of lifelong oral inflammatory exposure. While causal relationships cannot be established, this study provides a basis for future mechanistic and longitudinal investigations.
  • Prevention of Tooth Discoloration Using Fluoride Varnish Immediately After Bleaching
    Ryotaro Yago; Chiharu Kawamoto; Rafiqul Islam; Hirofumi Kaneko; Monica Yamauti; Masayuki Otsuki; Hidehiko Sano; Atsushi Tomokiyo
    Journal of Functional Biomaterials, 16, 7, 245, 245, MDPI AG, 03 Jul. 2025, [Peer-reviewed]
    Scientific journal, Tooth bleaching is a widely used esthetic treatment; however, bleaching agents can temporarily alter the surface morphology of enamel, increasing surface roughness and porosity, which may lead to increased susceptibility to discoloration. This in vitro study investigated the effectiveness of fluoride varnish in preventing immediate discoloration of bovine incisors after bleaching. Specimens were bleached with 35% hydrogen peroxide and treated with either Clinpro White Varnish (CW) or Enamelast Fluoride Varnish (EN), whereas control specimens received no treatment after bleaching. The samples were immersed in coffee for 24 h, and the color difference (ΔE00) was calculated using the CIEDE2000 formula. The surface morphology of enamel was examined using SEM. The fluoride varnish groups showed significantly lower color difference values than the control group (p < 0.05), with ΔE00 reduced by approximately two-thirds in both the CW and EN groups. SEM observations showed that the enamel surfaces in the varnish-treated groups exhibited reduced surface irregularities compared to the untreated group, suggesting remineralization. These results suggest that the immediate application of fluoride varnish after bleaching can effectively reduce short-term discoloration by providing physical protection and promoting remineralization. Fluoride varnish may serve as a simple and effective strategy to maintain whitening outcomes and minimize early discoloration.
  • Evaluation of Shade Integration of a Novel Universal-Shade Flowable Bulk-Filling Resin Composite.
    Hirofumi Kaneko; Chiharu Kawamoto; Yu Toida; Ryotaro Yago; Di Wu; Yuan Yuan; Fei Chen; Monica Yamauti; Hidehiko Sano; Atsushi Tomokiyo
    Materials (Basel, Switzerland), 17, 23, 04 Dec. 2024, [Peer-reviewed], [Lead author], [International Magazine]
    English, Scientific journal, BACKGROUND: This study aimed to evaluate the color-matching and light transmission properties of a newly developed aesthetic flowable resin composite, OCFB-001. METHODS: Rubber molds containing cylindrical cavities were filled with Estelite Sigma Quick, and 40 resin composite (CR) molds with simulated Class I cavities were prepared in shades A1, A2, A3, and A4, resulting in a total of 160 samples. Following bonding procedures, four different flowable resin composites (n = 10) were introduced into the cavities. The color difference (ΔE00) was calculated using two methods. A two-way analysis of variance was performed, and the interaction was significant, so a post hoc analysis was performed for each shade using Bonferroni's correction. The morphology of the filler in each material was observed via scanning electron microscopy (SEM). RESULTS: In the A1 shade, OCFB-001 demonstrated color differences comparable to those of other materials. However, in the A2, A3, and A4 shades, OCFB-001 exhibited significantly lower color differences (ΔE00) than the other materials, with a more consistent distribution. SEM analysis revealed that the OCFB-001 structure resembled that of Estelite Bulk Fill Flowable. CONCLUSIONS: OCFB-001 showed excellent shade matching in the A2, A3, and A4 ranges and good matching in the A1 shade, on par with existing universal-shade flowable bulk-fill resin composites.
■ Lectures, oral presentations, etc.
  • Evaluation of Shade Matching of a Novel Universal Shade Flowable Bulk-Filling Resin Composite
    兼子 裕史; 川本 千春; 戸井田 侑; 呉 迪; 矢後 亮太朗; 袁 媛; 遠山 晏梨; 國井 理恵子; 松尾 友太; 弥勒院 択良; 山内 モニカ; 佐野 英彦; 友清 淳
    日本歯科保存学会秋季学術大会（第159回）, Japanese, Poster presentation
    11 Nov. 2023 - 12 Nov. 2023
■ Affiliated academic society
  • Sep. 2025 - Present
    日本歯科審美学会
  • Apr. 2021 - Present
    北海道歯学会
  • Apr. 2021 - Present
    日本歯科保存学会
■ Research Themes