Researcher basic information

• 博士（歯学）, 北海道大学

• https://researchmap.jp/read0055084?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901081496243453

• 200901081496243453

• 咀嚼運動
• 主成分分析
• 下顎運動
• 下顔面皮膚の運動
• 主成分
• 非習慣性咀嚼側
• 運動パターン
• 身体重心動揺
• Maximum peak
• 動的咬合
• 咬合
• 3次元・多点同時時系列解析
• 側帯域波
• Spectrum
• 運動リズム
• 個体内評価
• 下顔面皮膚上の運動
• 咀嚼リズム
• 下肢長差
• 咬合と全身
• 全身姿勢
• 頭位
• 咬合バランス
• 頭頸部筋筋活動
• 咬合接触圧
• 咬合接触圧分布値
• 身体機能
• リアルタイム3次元座標計測
• 全身機能
• 握力
• 歯科補綴学

• Life Science, Prosthodontics

• Bachelor's degree program, School of Dental Medicine
• Doctoral (PhD) degree program, Graduate school of Dental Medicine

Research activity information

• Effects of Composite Resin Teeth Versus Porcelain Teeth in Complete Dentures on Oral Health-Related Quality of Life, Masticatory Function, and Patient Satisfaction: A Randomized Controlled Trial.
  Asuka Kodama; Toshifumi Nogawa; Yoshiyuki Takayama; Kiwamu Sakaguchi; Atsuro Yokoyama
  Dentistry journal, 14, 2, 03 Feb. 2026, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Background/Objectives: Artificial teeth in complete dentures are classified according to the materials used: porcelain (PO) or composite resin (CR). However, these materials' effects on function, patient satisfaction, and quality of life (QOL), as well as occlusal wear, remain unclear. We compared PO and CR complete dentures in edentulous patients by assessing masticatory function, patient satisfaction, and oral health-related QOL at 3, 6, and 12 months post-insertion, as well as occlusal surface morphology owing to material differences. Methods: In this open-label, randomized, single-center, parallel-group study, participants were edentulous patients who visited our hospital and underwent treatment with new complete dentures. The outcomes were oral health-related QOL; subjective satisfaction, assessed using a visual analog scale; and masticatory performance, evaluated with gummy jelly and were assessed at baseline and 3, 6, and 12 months post-denture insertion. Occlusal surface impressions were taken twice, digitized as STL models, superimposed, and analyzed for wear. The Wilcoxon rank-sum test was used to compare between groups. Results: All evaluated items showed improvement. However, no significant differences were observed between the PO and CR groups, including between the amount of wear observed in the two groups. However, the PO group showed a tendency toward less wear. Extended observation may be required to clarify the long-term effects of artificial tooth materials. Conclusions: In the short term, the artificial tooth material did not influence masticatory function, oral health-related QOL, or patient satisfaction.
• Carbon nanohorn coating on titanium promotes M2 macrophage polarization.
  Sadahito Kimura; Eri Hirata; Yuta Takano; Miho Ibi; Natsumi Ushijima; Eijiro Miyako; Masako Yudasaka; Yukari Maeda; Daisuke Konishi; Kiwamu Sakaguchi; Atsuro Yokoyama
  Dental materials journal, 44, 5, 564, 571, 30 Sep. 2025, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, This study investigated the effects of carbon nanohorns (CNHs) coated on titanium surfaces on macrophage responses. The CNHs were electrodeposited on titanium discs to create a uniform coating with a thickness of 0.2-0.3 µm. Analysis of macrophages cultured on CNH-modified titanium (CNH/Ti) revealed decreased production of pro-inflammatory cytokines (TNFα and IL6) and increased IL10 gene expression compared to unmodified titanium. Immunofluorescence analysis showed higher expression of the M2 marker CD206 and lower expression of the M1 marker CD86 on the CNH/Ti surfaces. Gene expression analysis indicated downregulation of genes involved in DNA transcription, repair, and replication, correlating with controlled cell proliferation on CNH/Ti. These findings demonstrate that CNH modification on titanium surfaces influences macrophage cytokine production and phenotype marker expression, suggesting its potential application in dental implant development.
• Histochemical assessment of the femora of Spontaneously Diabetic Torii-Leprfa (SDT-fa/fa) rats that mimic type II diabetes.
  Qi Yao; Kanako Tsuboi; Hiromi Hongo; Mako Sakakibara; Tomomaya Yamamoto; Mai Haraguchi-Kitakamae; Hotaka Ishizu; Xuanyu Liu; Yan Shi; Weisong Li; Jiaxin Cui; Tomohiro Shimizu; Norio Amizuka; Atsuro Yokoyama; Tomoka Hasegawa; Kiwamu Sakaguchi
  Journal of oral biosciences, 67, 1, 100602, 100602, 18 Dec. 2024, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal
• Mechanical Effect of an Implant Under Denture Base in Implant-Supported Distal Free-End Removable Partial Dentures.
  Naomichi Murashima; Yoshiyuki Takayama; Toshifumi Nogawa; Atsuro Yokoyama; Kiwamu Sakaguchi
  Dentistry journal, 12, 11, 11 Nov. 2024, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal, Background: In recent years, implant-assisted removable partial dentures (IARPDs) have been used clinically. However, the extent to which additional implants reduce the burden of supporting tissues is unclear. The aim of this study was therefore to investigate the influence of implanted IARPDs on stress sharing among supporting tissues, using finite element (FE) analysis. Methods: FE models were constructed based on the computed tomography (CT) of a patient with a unilateral defect of the mandibular premolars and molars and the surface data of an RPD with cuspids as abutments, designed using computer-aided design software. A titanium implant was placed in the area equivalent to the first premolar, second premolar, or first molar (IARPD4, IARPD5, and IARPD6, respectively). FE analysis was performed for laterally symmetrical models, i.e., bilateral distal free-end IARPDs. A vertical load of 200 N was applied to the central fossa of the artificial premolars or molars (L4, L5, or L6). Results: Equivalent stress in the alveolar mucosa and vertical displacement of the denture was smaller, with IARPDs under L5 and L6 loads, compared to RPDs. However, abutment teeth were displaced upward under an L6 load in the IARPD5 model. Conclusions: Within the limitations of this study, the area corresponding to the first molar was recommended as the location for an implant under the denture base of bilateral distal free-end IARPDs. Implants located in the area corresponding to the second premolar may apply non-physiological extrusion force on abutment teeth under the load on the artificial second molar.
• Effect of masticatory movements on head and trunk sways, and sitting and foot pressure distributions during sitting position.
  Kiwamu Sakaguchi; Noshir R Mehta; Tomoaki Maruyama; Leopoldo P Correa; Atsuro Yokoyama
  Journal of oral rehabilitation, 50, 11, 1253, 1260, Nov. 2023, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, BACKGROUND: The head plays an important role in the postural control. Chewing co-activates jaw and neck muscles leading to coordinated jaw and head-neck movements. Therefore, to examine effect of masticatory movements on head and trunk sways, and sitting and foot pressure distributions during mastication is helpful in the attempt to understand the interrelationship between stomatognathic function and posture control system in the sitting position. OBJECTIVES: The purpose of this study was to test the hypothesis in healthy subjects that masticatory movements affect head and trunk sways and sitting and foot pressure distributions during sitting position. METHODS: A total of 30 healthy male subjects with an average age of 25.3  years (range, 22-32  years) were evaluated. The CONFORMat™ and MatScan™ system were used to analyse changes in sitting pressure distribution center of sitting pressure (COSP) and changes in foot pressure distribution center of foot pressure (COFP), respectively, and the three-dimensional motion analysis system was used to analyse changes in head and trunk postures while subjects remained sitting position with rest position, centric occlusion and chewing. The total trajectory length of COSP/COFP, COSP/COFP area, and head and trunk sway values were compared between the three conditions to evaluate whether masticatory movement affected the stability of head and trunk sways and sitting and foot pressure distributions. RESULTS: Total trajectory length of COSP and COSP area during chewing were significantly shorter and smaller respectively than it was in rest position and centric occlusion (p  ⟨  .016). Head sway value during chewing was significantly larger than it was in rest position and centric occlusion (p  ⟨  .016). CONCLUSION: Masticatory movements affect sitting pressure distribution and head movements during sitting position.
• Effect of sitting posture with and without sole-ground contact on chewing stability and masticatory performance.
  Kiwamu Sakaguchi; Noshir R Mehta; Tomoaki Maruyama; Leopoldo P Correa; Atsuro Yokoyama
  Journal of oral science, 65, 4, 251, 256, 01 Oct. 2023, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
  English, Scientific journal, PURPOSE: To verify the effect of sitting posture with and without sole-ground contact on chewing stability and masticatory performance. METHODS: Thirty healthy subjects were evaluated. The Conformat was used to analyze the center of sitting pressure (COSP), and the three-dimensional motion analysis system was used to analyze changes in head and trunk postures while subjects remained in a sitting position with and without sole-ground contact. The parameters of masticatory performance and movement were calculated as follows. For evaluating masticatory performance, the amount of glucose extraction (AGE) during chewing of a gummy jelly was measured. For evaluating masticatory movements, the movement of the mandibular incisal point was recorded using the Motion Visi-Trainer V1, and parameters of the stabilities of movement path and rhythm were calculated. RESULTS: Head and trunk sway values and the displacement of COSP were significantly smaller with sole-ground contact than those without sole-ground contact. The masticatory movement path with sole-ground contact showed less variation in the opening distance and more stable movement path compared to those without sole-ground contact. The AGE was significantly greater with sole-ground contact than that without sole-ground contact. CONCLUSION: Sitting posture with and without sole-ground contact affects chewing stability and masticatory performance.
• Effects of masticatory movements on the head, trunk and body sway during the standing position
  Keiko Shima; Kiwamu Sakaguchi; Noshir R. Mehta; Tomoaki Maruyama; Leopoldo P. Correa; Atsuro Yokoyama
  STOMATOLOGY EDU JOURNAL, 9, 3-4, Nov. 2022, [Peer-reviewed], [Corresponding author]
  English, Scientific journal
• Effect of body posture on stability and balance of occlusal contacts.
  Ken-Ichi Abe; Kiwamu Sakaguchi; Noshir R Mehta; Leopoldo P Correa; Emad F Abdallah; Atsuro Yokoyama
  Cranio : the journal of craniomandibular practice, 1, 11, 13 Sep. 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal
• Effects of Experimental Leg Length Discrepancies on Body Posture and Dental Occlusion
  Nozomi Maeda; Kiwamu Sakaguchi; Noshir R. Mehta; Emad F. Abdallah; Albert G. Forgione; Atsuro Yokoyama
  CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE, 29, 3, 194, 203, Jul. 2011, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal
• Examination of lower facial skin movements during left- and right-side chewing
  Kiwamu Sakaguchi; Nozomi Maeda; Atsuro Yokoyama
  JOURNAL OF PROSTHODONTIC RESEARCH, 55, 1, 32, 39, Jan. 2011, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
  English, Scientific journal
• Finite element model based on a mandibular cast and a waxed complete denture: Evaluation of the accuracy and the reproducibility of analysis
  Yoshiyuki Takayama; Hiroko Sasaki; Masayasu Saito; Kiwamu Sakaguchi; Kentaro Mizuno; Marie Goto; Atsuro Yokoyama
  JOURNAL OF PROSTHODONTIC RESEARCH, 53, 1, 33, 37, Jan. 2009, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal
• Examination of the relationship between mandibular position and body posture
  Kiwamu Sakaguchi; Noshir R. Mehta; Emad F. Abdallah; Albert G. Forgione; Hiroshi Hirayama; Takao Kawasaki; Atsuro Yokoyama
  CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE, 25, 4, 237, 249, Oct. 2007, [Peer-reviewed], [Lead author], [International Magazine]
  English, Scientific journal
• Time-series analyses of mandibular and perioral soft tissue movements during mastication
  K. Sakaguchi; T. Kawasaki; O. Araki
  Journal of Oral Rehabilitation, 30, 3, 270, 277, 01 Mar. 2003, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Spaciostructural analyses of mandibular and perioral soft tissue movements during mastication
  K. Sakaguchi; T. Kawasaki; T. Nakagawa; O. Araki; T. Kanayama; T. Kawashima
  Journal of Oral Rehabilitation, 28, 10, 982, 990, Oct. 2001, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Application of principal component analysis to the elucidation of perioral soft tissue movements during mastication
  K. Sakaguchi; T. Kawasaki; T. Kawashima; M. Toda; T. Nakagawa; T. Yamada; O. Araki
  Journal of Oral Rehabilitation, 28, 3, 286, 293, Mar. 2001, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal

• 頭蓋骨欠損モデルにおけるカーボンナノホーンチタンに対する初期生体応答の解析
  天野 元; 平田 恵理; 坂口 究; 横山 敦郎, 日本歯科理工学会誌, 45, Special Issue84, 70, 70, Apr. 2026
  (一社)日本歯科理工学会, Japanese
• 旧義眼を用いた効率的な義眼製作アプローチ
  山本 莉紗; 若林 侑輝; 川村 碧; 道田 共博; 前田 拓; 上田 康夫; 坂口 究, 日本口腔顎顔面技工学会会誌, 25, 1, 54,64, 55,64, Dec. 2025
  日本口腔顎顔面技工学会, Japanese
• ミノサイクリン-カーボンナノホーン複合体の生体内における光熱効果ならびに生体適合性の評価
  前田 由佳利; 平田 恵理; 高野 勇太; 小西 大輔; 横山 敦郎; 坂口 究, 日本口腔インプラント学会誌, 38, 4, E260, E261, Dec. 2025
  (公社)日本口腔インプラント学会, Japanese
• 歯科用卓上3Dスキャナーを用いた義眼の製作方法
  山本 莉紗; 若林 侑輝; 川村 碧; 道田 共博; 前田 拓; 上田 康夫; 坂口 究, 日本口腔顎顔面技工学会雑誌 = Journal of Japanese Academy of Oral and Maxillofacial Rehabilitation Technology, 25, 1, 7, 11, Dec. 2025
  [仙台] : [日本口腔顎顔面技工学会], Japanese
• 上顎洞癌術後の広範な骨欠損に対して分割型顎義歯を適用した一症例 構音機能と義歯安定性に配慮した補綴設計
  道田 共博; 川村 碧; 若林 侑輝; 山本 莉紗; 渡辺 さら; 後藤 まりえ; 坂口 究; 横山 敦郎, 日本口腔顎顔面技工学会学術大会プログラム・抄録集, 27回, np9, np9, Sep. 2025
  日本口腔顎顔面技工学会, Japanese
• 咬合・咀嚼の再考と有床義歯補綴診療の展望
  坂口 究, 日本補綴歯科学会誌, 17, 東北・北海道支部学術大会特別号, 23, 23, Sep. 2025
  (公社)日本補綴歯科学会, Japanese
• 全部床義歯の人工歯の材質が口腔関連QOLに及ぼす影響 装着後12ヵ月の評価
  古玉 明日香; 野川 敏史; 高山 芳幸; 横山 敦郎; 藤井 法博; 坂口 究, 日本補綴歯科学会誌, 17, 東北・北海道支部学術大会特別号, 37, 37, Sep. 2025
  (公社)日本補綴歯科学会, Japanese
• 咬合・咀嚼と有床義歯補綴診療の再考
  坂口 究, 日本補綴歯科学会誌, 17, 特別号, 140, 140, May 2025
  (公社)日本補綴歯科学会, Japanese
• 間接法による支台築造において材料とフェルールの高さがコアの生存率に及ぼす影響
  山下 小依花; 古玉 明日香; 野川 敏史; 高山 芳幸; 坂口 究, 日本補綴歯科学会誌, 17, 特別号, 255, 255, May 2025
  (公社)日本補綴歯科学会, Japanese
• カーボンナノチューブの直径が細胞接着性に与える影響
  屈 俊げつ; 平田 恵理; 坂口 究; 横山 敦郎, 日本歯科理工学会誌, 44, Special Issue83, 41, 41, Apr. 2025
  (一社)日本歯科理工学会, Japanese
• 旧義眼を用いた効率的な義眼製作アプローチ
  山本 莉紗; 若林 侑輝; 川村 碧; 道田 共博; 前田 拓; 上田 康夫; 坂口 究, 日本口腔顎顔面技工学会会誌, 24, 2, 23, 23, Nov. 2024
  日本口腔顎顔面技工学会, Japanese
• Effect of changes in body posture on head position and occlusal contacts
  小山拳人; 坂口究; 丸山智章; 前田望; 横山敦郎, 日本補綴歯科学会誌(Web), 16, 2024
• セメント固定方式における粘膜縁下へのセメント流入と取り残し防止の検討
  道田 智宏; 佐伯 和紀; 黒田 真司; 坂口 究; 横山 敦郎, 日本口腔インプラント学会誌, 36, 特別号, O, 2, Sep. 2023
  (公社)日本口腔インプラント学会, Japanese
• Effect of changes in body posture on mandibular movement during chewing
  小山拳人; 坂口究; 丸山智章; 横山敦郎, 日本補綴歯科学会誌(Web), 15, 2023
• 姿勢が咬合接触の安定性とバランスに及ぼす影響
  坂口 究; 丸山 智章; 横山 敦郎, 日本補綴歯科学会誌, 14, 特別号, 300, 300, Jul. 2022
  (公社)日本補綴歯科学会, Japanese
• 「有床義歯咀嚼機能検査について」 検査および評価から次のステップを目指して!
  坂口 究, 日本補綴歯科学会誌, 13, 東北・北海道支部学術大会特別号, 24, 24, Oct. 2021
  (公社)日本補綴歯科学会, Japanese
• 足底接地の有無が咀嚼運動と咀嚼能力に及ぼす影響
  坂口 究; 丸山 智章; 横山 敦郎, 日本補綴歯科学会誌, 13, 特別号, 252, 252, Jun. 2021
  (公社)日本補綴歯科学会, Japanese
• Effect of Grounding the Foot Bottom on Masticatory Movement and Masticatory Performance
  坂口究; 丸山智章; 横山敦郎, 日本補綴歯科学会誌(Web), 13, 2021
• 姿勢の変化が咀嚼能力に及ぼす影響
  坂口 究; 丸山 智章; 横山 敦郎, 日本補綴歯科学会誌, 12, 特別号, 246, 246, Jun. 2020
  (公社)日本補綴歯科学会, Japanese
• 咀嚼時における下顎、頭部、体幹、下肢の運動の関連性
  坂口 究; 丸山 智章; 横山 敦郎, 日本補綴歯科学会誌, 11, 特別号, 308, 308, May 2019
  (公社)日本補綴歯科学会, Japanese
• グミ咀嚼時における頭部と体幹の運動および足底圧の定量的評価 立位と座位の比較
  坂口 究; 丸山 智章; 横山 敦郎, 日本顎口腔機能学会雑誌, 25, 2, 122, 123, Mar. 2019
  日本顎口腔機能学会, Japanese
• 咀嚼が立位と座位の姿勢制御に及ぼす影響
  坂口 究; 丸山 智章; 横山 敦郎, 日本補綴歯科学会誌, 10, 特別号, 261, 261, Jun. 2018
  (公社)日本補綴歯科学会, Japanese
• 咀嚼運動と姿勢の同時計測
  知野 圭佑; 坂口 究; 丸山 智章; 横山 敦郎, 日本咀嚼学会雑誌, 27, 2, 109, 109, Nov. 2017
  (NPO)日本咀嚼学会, Japanese
• 咀嚼運動が座位姿勢に及ぼす影響 頭部、体幹および下肢の動揺の関連性
  知野 圭佑; 坂口 究; 丸山 智章; 横山 敦郎, 日本顎口腔機能学会雑誌, 24, 1, 32, 33, Sep. 2017
  日本顎口腔機能学会, Japanese
• 座位姿勢の変化が咀嚼機能に及ぼす影響
  知野 圭佑; 坂口 究; 丸山 智章; 横山 敦郎, 日本補綴歯科学会誌, 9, 特別号, 160, 160, Jun. 2017
  (公社)日本補綴歯科学会, Japanese
• 下顎位ならびに咀嚼運動が座位姿勢に及ぼす影響
  坂口 究; 知野 圭佑; 横山 敦郎, 日本全身咬合学会雑誌, 23, 1, 23, 23, May 2017
  (一社)日本全身咬合学会, Japanese
• 有床義歯装着者の機能評価のガイドライン(2016改訂版)
  皆木 省吾; 山崎 要一; 矢谷 博文; 志賀 博; 山口 泰彦; 服部 佳功; 吉田 教明; 石垣 尚一; 加藤 均; 三浦 宏之; 荒川 一郎; 岡本 和彦; 小野 高裕; 横山 正起; 岡田 和樹; 小川 徹; 菅沼 岳史; 藤澤 政紀; 沖 和広; 坂口 究; 重本 修伺; 瑞森 崇弘; 小見山 道; 田中 恭恵; 堀 一浩; 渡邉 明; 宮脇 正一; 山田 一尋; 斉藤 一誠; 長谷川 信乃; 早崎 治明; 井上 富雄; 井上 誠; 大川 周治; 川良 美佐雄; 祇園白 信仁; 小林 博; 古谷野 潔; 佐々木 啓一; 田中 昌博; 田村 康夫; 野村 修一; 藤村 哲也; 増田 裕次; 鱒見 進一; 倉持 淳子; 昆 はるか; 櫻井 直樹; 山本 早織; 日本顎口腔機能学会, 日本顎口腔機能学会ガイドライン統括委員会, 日本顎口腔機能学会雑誌, 23, 2, E3, E35, Mar. 2017
  日本顎口腔機能学会, Japanese
• 顎関節症患者の機能評価のガイドライン(2016改訂版)
  皆木 省吾; 山崎 要一; 矢谷 博文; 志賀 博; 山口 泰彦; 服部 佳功; 吉田 教明; 石垣 尚一; 加藤 均; 三浦 宏之; 荒川 一郎; 岡本 和彦; 小野 高裕; 横山 正起; 岡田 和樹; 小川 徹; 菅沼 岳史; 藤澤 政紀; 沖 和広; 坂口 究; 重本 修伺; 瑞森 崇弘; 小見山 道; 田中 恭恵; 堀 一浩; 渡邉 明; 宮脇 正一; 山田 一尋; 斉藤 一誠; 長谷川 信乃; 早崎 治明; 井上 富雄; 井上 誠; 大川 周治; 川良 美佐雄; 祇園白 信仁; 小林 博; 古谷野 潔; 佐々木 啓一; 田中 昌博; 田村 康夫; 野村 修一; 藤村 哲也; 増田 裕次; 鱒見 進一; 倉持 淳子; 昆 はるか; 櫻井 直樹; 山本 早織; 日本顎口腔機能学会, 日本顎口腔機能学会ガイドライン統括委員会, 日本顎口腔機能学会雑誌, 23, 2, E37, E109, Mar. 2017
  日本顎口腔機能学会, Japanese
• Current status of clinical examinations for dental occlusion and masticatory function
  坂口 究; 知野 圭佑; 横山 敦郎, 北海道歯学雑誌, 37, 2, 177, 180, Mar. 2017
  健康寿命（2000年にWHOが提唱した「健康上の問題で 日常生活が制限されることなく生活できる期間」）は，男 性が約71歳，女性が約74歳（厚生労働省，2013年）であ り，平均寿命（男性：約80歳，女性：約86歳）との差が約 10年もあると報告されている．この差を解消し，健康寿命の延伸を図るために多くの試みが実施されている．厚生労働省の「健康日本21」（第２次：2013～2022年度）では，「健全な口腔機能を生涯にわたり維持することができるよう，疾病予防の観点から，歯周病予防，う蝕予防に着目するとともに，歯の喪失防止に加え，口腔機能の維持・向上について設定する」としている．健全な口腔機能を維持するためには，良好に咀嚼できることが必須である．また，健康やQOLに関する国民の意識レベルの向上に伴い，質の高い医療と治療効果を客観的に評価し，患者に呈示するエビデンスに基づいた医療が求められている． 平成23年から実施されていた先進医療技術「有床義歯補綴治療における総合的咬合・咀嚼機能検査」が，平成28年度診療報酬改定により，「有床義歯咀嚼機能検査」として保険導入された．本検査は，咀嚼時の下顎運動と咀嚼能力の検査を行うことにより，咬合と咀嚼機能の状態を総合的に評価するものである．これらの検査により，口腔機能，特に咀嚼機能について，治療前の障害程度，治療後の回復程度，および定期検査時の維持程度に関する客観的評価が可能となるため，患者の口腔の健康を維持・増進するために活用することができる． 北大病院歯科診療センターにおいても本検査の施設基準に係る届出が，厚生労働省北海道厚生局に受理されている．本稿においては，本検査法の概要とその臨床応用について紹介する．, 北海道歯学会, Japanese
• 咀嚼運動が座位姿勢保持時の座圧と足底圧に及ぼす影響
  知野 圭佑; 坂口 究; 横山 敦郎, 日本補綴歯科学会誌, 8, 特別号, 125, 125, Jul. 2016
  (公社)日本補綴歯科学会, Japanese
• ガム咀嚼が姿勢制御に及ぼす影響 頭部、体幹、身体重心動揺の関連性について
  坂口 究; 島 恵子; 丸山 智章; 横山 敦郎, 日本補綴歯科学会誌, 7, 特別号, 147, 147, May 2015
  (公社)日本補綴歯科学会, Japanese
• 口腔疾患の治療や口腔機能の維持・回復が全身の健康に与える影響に関するプロジェクト研究 歯科治療による口腔機能の改善が健康に及ぼす影響に関する臨床データベースの構築
  志賀 博; 横山 正起; 横山 敦郎; 坂口 究; 服部 佳功; 依田 信裕; 赤川 安正; 川良 美佐雄; 大川 周治; 祇園白 信仁; 小野 高裕; 前田 芳信; 皆木 省吾; 津賀 一弘; 鱒見 進一; 佐々木 啓一, 日本歯科医学会誌, 34, 69, 73, Mar. 2015
  日本歯科医学会, Japanese
• 咀嚼運動が頭部動揺,体幹動揺,身体重心動揺に及ぼす影響
  島恵子; 坂口究; 丸山智章; 横山敦郎, 日本補綴歯科学会学術大会プログラム・抄録集, 123rd, 特別号, 116, 116, 01 Apr. 2014
  (公社)日本補綴歯科学会, Japanese
• 咀嚼機能が重心動揺に及ぼす影響
  島 恵子; 坂口 究; 前田 望; 横山 敦郎, 日本補綴歯科学会誌, 5, 特別号, 140, 140, May 2013
  (公社)日本補綴歯科学会, Japanese
• 立位における咀嚼機能の客観的評価に関する研究
  島 恵子; 坂口 究; 阿部 賢一; 前田 望; 横山 敦郎, 日本補綴歯科学会誌, 5, 1, E134, E134, Jan. 2013
  (公社)日本補綴歯科学会, Japanese
• Time-series analysis of occlusal contacts with the change of body posture
  Abe K.; Sakaguchi K.; Maeda N.; Shima K.; Yokoyama A., The Journal of Japanese Society of Stomatognathic Function, 19, 2, 164, 165, 2013
  Japanese Society of Stomatognathic Function, Japanese
• 姿勢の変化が咬合接触に及ぼす影響
  阿部 賢一; 坂口 究; 前田 望; 島 恵子; 横山 敦郎, 日本補綴歯科学会誌, 4, 特別号, 257, 257, May 2012
  (公社)日本補綴歯科学会, Japanese
• Effect of habitual chewing side on masticatory function
  SAKAGUCHI Kiwamu; YOKOYAMA Masaoki; WATANABE Atsushi; ABE Kenichi; IWASHITA Hayato; URATA Kentaro; KUMASAKI Yohei; KAWANO Toshihiro; KOBARI Hiromori; TAMAKI Junichiro; FUKUI Yusuke; FUJISHITA Ayumi; MIYAGI Hiroshi; SHIGA Hiroshi, The Journal of Japanese Society of Stomatognathic Function, 18, 2, 152, 160, 28 Feb. 2012
  Purpose: The purpose of this study was to elucidate the effect of the habitual chewing side on masticatory performance by examining the functional difference between chewing on the habitual and the non-habitual chewing sides. Methods: Ten asymptomatic subjects (ages 26-33 years, mean age 28.7 years) who participated in the 7^th seminar of the Japanese Society of Stomatognathic Function were included in this study. The stability of masticatory path and rhythm and the patterns of masticatory movement path were compared between the habitual chewing side and the non-habitual chewing side during gum chewing. The glucose extraction as the indicator for masticatory function was compared between the two sides. Results: The values of the three indicators representing the stability of masticatory path and rhythm on the habitual chewing side were smaller compared to those on the non-habitual chewing side in 6 of 10 subjects. The glucose extraction on the habitual chewing side was significantly larger than that on the non-habitual chewing side. The majority of subjects, 8 of 10 subjects, showed Pattern I and Pattern III during chewing on the habitual chewing side. When the frequent pattern on the two sides was scored in order to evaluate quantitatively the stability of masticatory movement, the score for the habitual chewing side was larger than it for the non-habitual chewing side in 5 of 10 subjects, and the scores on the two sides were equal in 3 of 10 subjects. Conclusion: The present results suggested the following possibility: 1. Functional differences were found between chewing on the habitual chewing side and chewing on the non-habitual chewing side. Moreover, it was concluded that masticatory performance for chewing on the habitual chewing side was superior to it for chewing on the non-habitual chewing side. 2. Measurement of the glucose extraction as the indicator for ability of mastication, the pattern of masticatory movement path and the stability of masticatory path and rhythm (the values of the indicators representing the stability of masticatory path and rhythm) were useful for the quantitative evaluation of masticatory performance., Japanese Society of Stomatognathic Function, Japanese
• Effect of habitual chewing side on dental occlusion and masticatory function
  SAKAGUCHI Kiwamu; YOKOYAMA Masaoki; WATANABE Atsushi; ABE Kenichi; IWASHITA Hayato; URATA Kentaro; KUMASAKI Yohei; KAWANO Toshihiro; KOBARI Hiromori; TAMAKI Junichiro; FUKUI Yusuke; FUJISHITA Ayumi; MIYAGI Hiroshi; SHIGA Hiroshi, The Journal of Japanese Society of Stomatognathic Function, 18, 2, 182, 183, 28 Feb. 2012
  Japanese Society of Stomatognathic Function, Japanese
• 客観的咬合評価のパラメータと標準値確立への試み 自然直立姿勢時の標準値について
  阿部 賢一; 坂口 究; 前田 望; 島 恵子; 横山 敦郎, 日本補綴歯科学会誌, 4, 1, E16, E16, Jan. 2012
  (公社)日本補綴歯科学会, Japanese
• Dr. Giuseppe Perinetti comments on Dr. Nozomi Maeda, et al.'s article (pps. 194-203) in CRANIO's July, 2011 issue. Response
  Kiwamu Sakaguchi; Nozomi Maeda; Atsuro Yokoyama; Noshir R. Mehta; Emad F. Abdallah; Albert G. Forgione, CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE, 29, 4, 254, 254, Oct. 2011
  English, Report scientific journal
• 【開業医のための明快咬合臨床 診査・診断から治療まで】(第2章)咬合にかかわる検査と診断 咬合と全身 咬合と全身姿勢の関連性
  坂口 究; 前田 望; 阿部 賢一; 島 恵子; 横山 敦郎, DENTAL DIAMOND, 36, 10, 78, 83, Jul. 2011
  (株)デンタルダイヤモンド社, Japanese
• 【開業医のための明快咬合臨床 診査・診断から治療まで】(第4章)症例集 客観的咬合データをもとにしたスプリントタイプの治療用義歯による咬合及び補綴治療の実際
  坂口 究; 西川 圭吾; 前田 望; 大澤 孝; 横山 敦郎, DENTAL DIAMOND, 36, 10, 118, 126, Jul. 2011
  (株)デンタルダイヤモンド社, Japanese
• 実験的に付与した脚長差が直立姿勢,頭位および顎口腔機能に及ぼす影響について
  前田望; 坂口究; 丸山智章; 横山敦郎, 日本補綴歯科学会学術大会プログラム・抄録集, 120th, 特別号, 252, 252, 01 May 2011
  (公社)日本補綴歯科学会, Japanese
• 顎関節症患者の機能評価のガイドライン
  志賀 博; 井上 富雄; 津賀 一弘; 山崎 要一; 吉田 教明; 山口 泰彦; 岡田 和樹; 小林 博; 藤澤 政紀; 坂口 究; 瑞森 崇弘; 矢谷 博文; 佐々木 啓一; 田中 昌博; 服部 佳功; 古屋 良一; 中野 雅徳; 松本 敏彦; 日本顎口腔機能学会; 顎口腔機能評価検討委員会; 顎関節症患者の機能評価のガイドライン作成委員会, 日本顎口腔機能学会雑誌, 17, ガイドライン, E48, E110, Sep. 2010
  日本顎口腔機能学会, Japanese
• Effect of Experimental Leg Length Discrepancy on Body Sway, Head Posture, Head and Neck Muscle Activity and Occlusion
  MAEDA N; SAKAGUCHI K; MARUYAMA T; YOKOYAMA A, 日本補綴歯科学会誌. 特別号, 社団法人日本補綴歯科学会学術大会プログラム・抄録集 = Program and abstracts, the ... scientific meeting of Japan Prosthodontic Society, 1, 118, 174, 174, 16 Aug. 2010
  Japanese
• 実験的な姿勢変化が重心動揺,頭部動揺および顎口腔機能に及ぼす影響について
  前田望; 坂口究; 丸山智章; 横山敦郎, 日本補綴歯科学会学術大会プログラム・抄録集, 119th, 103, 15 May 2010
  Japanese
• Effect of changing body posture on body sway, head posture, head and neck muscle activity and occlusion
  MAEDA Nozomi; SAKAGUCHI Kiwamu; MARUYAMA Tomoaki; YOKOYAMA Atsuro, The Journal of Japanese Society of Stomatognathic Function, 16, 2, 146, 147, 28 Feb. 2010
  Japanese Society of Stomatognathic Function, Japanese
• 咬合検査機器を活用したスプリント型治療用義歯による咬合治療の実際
  坂口 究; 横山 敦郎, 歯科技工 38, 38, 9, 1020, 1030, 2010
  医歯薬出版(株), Japanese
• 5. Effect of experimental leg length discrepancy on body posture and occlusion
  Maeda Nozomi; Sakaguchi Kiwamu; Yokoyama Atsuro, The Journal of Japanese Society of Stomatognathic Function, 15, 2, 150, 151, 28 Feb. 2009
  Japanese Society of Stomatognathic Function, Japanese
• A Case Report of Complete Denture with a Favorable Prognosis through Improvements of the Mandibular Position and the Unilateral Mastication
  SAKAGUCHI Kiwamu, Annals of Japan Prosthodontic Society, 1, 1, 101, 104, 10 Jan. 2009
  Patient: The patient was a 75 years edentulous male with the chief complaint of chewing difficulty. The anterior half of the maxillary alveolar ridge was flabby-gum tissue, and both maxillary and mandibular alveolar ridges inclined anteriorly. Mandibular position was deviated to the anterior right side, and the patient had a habit of unilateral mastication. Treatment dentures were used to improve mandibular position, unilateral mastication and masticatory function.
  Discussion: Some methods to arrange the artificial teeth were adopted in order to avoid vertical and horizontal dislodgement of dentures when new dentures were fabricated. Moreover, stability and satisfaction with new dentures were obtained by improvements of mandibular position and unilateral mastication.
  Conclusion: As a result of appropriate distribution of occlusal force by considering impression taking, registration of inter-occlusal relation and arrangement of artificial teeth, a favorable prognosis was obtained., Japan Prosthodontic Society, Japanese
• 北海道大学病院歯科診療センターにおけるインプラント症例の補綴学的考察
  小松原 浩実; 堀内 留美; 坂口 究; 山本 悟; 飯田 俊二; 斎藤 正恭; 横山 敦郎, 日本補綴歯科学会誌, 1, 1, E42, E42, Jan. 2009
  (公社)日本補綴歯科学会, Japanese
• 咬合検査機器を用いた客観的データに基づく補綴治療の新展開咬合接触圧分布測定システム"T-Scan"を用いて動的咬合評価を行った症例から
  坂口 究; 前田 望; 横山 敦郎, 歯界展望 114, 114, 3, 534, 536, 2009
  医歯薬出版(株), Japanese
• A Case Report of Complete Denture with a Favorable Prognosis through Improvements of the Mandibular Position and the Unilateral Mastication
  Sakaguchi Kiwamu, Annals of Japan Prosthodontic Society, 1, 1, 101, 104, 2009
  Patient: The patient was a 75 years edentulous male with the chief complaint of chewing difficulty. The anterior half of the maxillary alveolar ridge was flabby-gum tissue, and both maxillary and mandibular alveolar ridges inclined anteriorly. Mandibular position was deviated to the anterior right side, and the patient had a habit of unilateral mastication. Treatment dentures were used to improve mandibular position, unilateral mastication and masticatory function.
  Discussion: Some methods to arrange the artificial teeth were adopted in order to avoid vertical and horizontal dislodgement of dentures when new dentures were fabricated. Moreover, stability and satisfaction with new dentures were obtained by improvements of mandibular position and unilateral mastication.
  Conclusion: As a result of appropriate distribution of occlusal force by considering impression taking, registration of inter-occlusal relation and arrangement of artificial teeth, a favorable prognosis was obtained., Japan Prosthodontic Society, Japanese
• Finite element model based on a mandibular cast and a waxed complete denture: Evaluation of the accuracy and the reproducibility of analysis
  Yoshiyuki Takayama; Hiroko Sasaki; Masayasu Saito; Kiwamu Sakaguchi; Kentaro Mizuno; Marie Goto; Atsuro Yokoyama, JOURNAL OF PROSTHODONTIC RESEARCH, 53, 1, 33, 37, Jan. 2009
  English
• The Effect of Changing whole Body Posture on Occlusion
  MAEDA N; SAKAGUCHI K; YOKOYAMA A, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 52, 117, 110, 110, 06 Jun. 2008
  Japanese
• Time-Series Analyses of Body Sway and Occlusion : The Comparison of Asymptomatic Subjects and TMD Patients with Myofacial Pain
  SAKAGUCHI K; MEHTA Noshir R; MAEDA N; YOKOYAMA A, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 51, 116, 84, 84, 18 May 2007
  (公社)日本補綴歯科学会, Japanese
• Examination of the Relationship between Mandibular Position and Body Posture
  SAKAGUCHI K; NOSHIR R Mehta; YOKOYAMA A, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 50, 115, 222, 222, 08 Jul. 2006
  (公社)日本補綴歯科学会, Japanese
• 有限要素解析に基づく下顎無歯顎堤の分類 主成分分析とクラスター分析の応用
  高山 芳幸; 佐々木 紘子; 齋藤 正恭; 坂口 究; 水野 健太郎; 後藤 まりえ; 横山 敦郎, 日本補綴歯科学会雑誌, 49, 114回特別, 76, 76, Oct. 2005
  (公社)日本補綴歯科学会, Japanese
• 下顎位と全身姿勢の相互関係の解明
  坂口 究; Mehta Noshir R; Abdallah Emad F; Forgione Albert G; 平山 洋; 川崎 貴生, 日本補綴歯科学会雑誌, 49, 113回特別, 57, 57, May 2005
  (公社)日本補綴歯科学会, Japanese
• Elucidation of Movements of the Lower Face Skin during Mastication : Evaluation of the Motion Function on the Left and Right Chewing Sides between Individuals
  SAKAGUCHI K; KAWASAKI T, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 46, 108, 67, 67, 11 Oct. 2002
  (公社)日本補綴歯科学会, Japanese
• Elucidation of the Skin Movements of the Lower Face during Masticatory Movements : Analyses on Habitual Chewing Side and Non-habitual Chewing Side
  KAWASAKI T; SAKAGUCHI K; ARAKI O; TANAHASHI S, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 45, 106, 141, 141, 26 Oct. 2001
  (公社)日本補綴歯科学会, Japanese
• Time-Series Analyses of the Skin of the Lower Face and Mandibular Movements during Mastication
  KAWASAKI T; SAKAGUCHI K; ARAKI O, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 44, 104, 72, 72, 10 Nov. 2000
  (公社)日本補綴歯科学会, Japanese
• Kinematic Analyses of the Rythm between Perioral Soft Tissue and Mandibular Movements during Mastication
  ARAKI O; SAKAGUCHI K; KAWASAKI T, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 44, 104, 73, 73, 10 Nov. 2000
  (公社)日本補綴歯科学会, Japanese
• Spaciostructural Analyses of Perioral Soft Tissue and Mandibular Movements during Mastication
  KAWASAKI T; SAKAGUCHI K; ARAKI O; NAKAGAWA T; KAWASHIMA T, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 44, 103, 84, 84, 09 Jun. 2000
  (公社)日本補綴歯科学会, Japanese
• A spatiostructural analysis of perioral soft tissue movement during mastication : Application of the principal component analysis
  Sakaguchi Kiwamu; Kawasaki Takao, The Journal of Japanese Society of Stomatognathic Function, 5, 2, 101, 114, 30 Mar. 1999
  The first aim of this study was clarify whether principal component analysis(PCA), one of the multivariate analysis, can reduce the number of degrees of freedom of perioral skin movement(i.e., time-siries data with 45 degrees of freedom). The second was to evident whether the analysis of the movement of perioral soft tissue during mastication by the application of PCA is useful to evaluate masticatory movement and stomatognathic functions. The subjects were 15 persons with natural dentition and 4 complete denture wearers. The chosen experimental food for this study was sufficiently softened..., Japanese Society of Stomatognathic Function, Japanese
• 咀嚼時口唇付近の動きに関する空間的構造分析 主成分分析の応用
  坂口 究, 北海道歯学雑誌, 19, 2, 286, 286, Dec. 1998
  北海道歯学会, Japanese
• Time-Series Analysis of Multi-Point Movements of Lips and Adjacents Regions during Mastication : Application of Principal Component Analysis Part2
  SAKAGUCHI K; TODA M; SETAKA M; YAMADA T; KAWASAKI T; NAGASAKI K; KAWASHIMA T; AOKI Y, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 41, 98, 146, 146, 16 Oct. 1997
  (公社)日本補綴歯科学会, Japanese
• Time-Series Analysis of Multi-Point Movements of Lips and Adjacents Regions during Mastication : Application of Principal Component Analysis
  SAKAGUCHI K; SETAKA M; TAKAYAMA Y; YAMADA T; KAWASAKI T; TODA M; NAGASAKI K; KAWASHIMA T; AOKI Y, 日本補綴歯科学会雑誌. 特別号, 日本補綴歯科学会学術大会抄録集 = Proceedings of the ... conference, the Japan Prosthodontic Society, 41, 97, 169, 169, 30 May 1997
  (公社)日本補綴歯科学会, Japanese
• Time-series analysis of multi-point movements of lips and adjacent regions during mastication : Part 2. Analysis of individual targets
  SETAKA Masashi; SAKAGUCHI Kiwamu; KAWASAKI Takao; NAGASAKI Takeshi; KAWASHIMA Toshio; AOKI Yoshinao, 北海道歯学雑誌, 17, 1, 72, 80, 15 Jun. 1996
  本解析法を用いて顎口腔系の機能評価を行う場合には,咀嚼側口角結節部標点と非咀嚼側頬部下方標点の2つが運動の円滑さの差を認めやすい標点であり,全ての標点を用いずとも,これらの2つの標点を用いれば顎口腔機能の評価を行えた.咀嚼側上唇部標点,正中上唇部標点,下唇正中部標点,非咀嚼側上唇部標点といった口唇周囲の標点は有意差を生じにくい標点であった.更に,本研究の解析項目の中で加速度のピーク数は最も感度の高い解析法であった, 北海道歯学会, Japanese

• 有床義歯補綴学, 2024年, 博士後期課程, 歯学院
• 咀嚼機能回復学, 2024年, 博士後期課程, 歯学院
• 有床義歯補綴学, 2024年, 博士後期課程, 歯学院
• 発表・論文執筆法演習Ⅰ, 2024年, 博士後期課程, 歯学院
• 発表・論文執筆法演習Ⅱ, 2024年, 博士後期課程, 歯学院
• 発表・論文執筆法演習Ⅲ, 2024年, 博士後期課程, 歯学院
• 有床義歯補綴学, 2024年, 博士後期課程, 歯学院
• 口腔機能学実習Ⅰ, 2024年, 博士後期課程, 歯学院
• 口腔機能学実習Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔機能学実習Ⅲ, 2024年, 博士後期課程, 歯学院
• 口腔機能学実習Ⅳ, 2024年, 博士後期課程, 歯学院
• 口腔機能学実習Ⅴ, 2024年, 博士後期課程, 歯学院
• 有床義歯補綴学研究Ⅰ, 2024年, 博士後期課程, 歯学院
• 有床義歯補綴学, 2024年, 博士後期課程, 歯学院
• 咀嚼機能回復学研究Ⅰ, 2024年, 博士後期課程, 歯学院
• 咀嚼機能回復学, 2024年, 博士後期課程, 歯学院
• 咀嚼機能回復学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 有床義歯補綴学研究Ⅱ, 2024年, 博士後期課程, 歯学院
• 口腔生物学と医学, 2024年, 博士後期課程, 歯学院
• 歯科学概論Ⅰ, 2024年, 学士課程, 歯学部
• 有床義歯補綴学臨床実習Ⅰ, 2024年, 学士課程, 歯学部
• 有床義歯補綴学臨床実習Ⅱ, 2024年, 学士課程, 歯学部
• 有床義歯補綴学, 2024年, 学士課程, 歯学部
• アクティブラーニング科目Ⅴ, 2024年, 学士課程, 歯学部
• アクティブラーニング科目Ⅵ, 2024年, 学士課程, 歯学部
• 健康と社会, 2024年, 学士課程, 全学教育
• 有床義歯補綴学基礎実習, 2024年, 学士課程, 歯学部
• 一般教育演習(ﾌﾚｯｼｭﾏﾝｾﾐﾅｰ), 2024年, 学士課程, 全学教育
• フロンティア発展科目, 2024年, 学士課程, 歯学部
• 健康と社会, 2024年, 学士課程, 全学教育
• 内科学, 2024年, 学士課程, 歯学部

• 北海道歯学会
• 日本補綴歯科学会
• 国際歯科研究学会
• International Association of Dental Research
• 日本顎口腔機能学会
• 日本口腔インプラント学会
• 日本歯科理工学会
• 日本咀嚼学会
• 日本全身咬合学会

• Establishment of a foundation for AI-based prosthodontic diagnosis, treatment support, and clinical implementation based on dynamic causal inference between stomatognathic and systemic functions
  Grants-in-Aid for Scientific Research
  01 Apr. 2026 - 31 Mar. 2029
  坂口 究; 丸山 智章; 横山 敦郎
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 26K12771
• 顎口腔と全身の機能の因果：生体データ、シミュレーション、機械学習の応用による検証
  科学研究費助成事業
  01 Apr. 2023 - 31 Mar. 2026
  坂口 究; 丸山 智章; 横山 敦郎
  我々はこれまでに，咀嚼運動は，立位と座位ともに姿勢の安定性を高める可能性があることを報告してきた．しかしながら，それぞれの姿勢において，咀嚼運動が姿勢制御にどのような影響を及ぼし，姿勢の安定化が図られるのかについては不明な点が残されていた．今年度は，立位における咀嚼運動が頭部動揺，体幹動揺，足底圧荷重分布に及ぼす影響とこれらの関連性について明らかにすることを目的とした．
  立位（自然直立姿勢）において，下顎安静位，咬頭嵌合位，グミ咀嚼時の各条件下，頭部動揺，体幹動揺，足底圧荷重分布の同時計測を行った．頭部動揺と体幹動揺の計測は，3次元画像解析システムを用いて，頭部と体幹にそれぞれ設定した4計測点の動作解析を行った．頭部動揺の安定性評価の定量的指標には，頭部に設定した4計測点の重心の平均座標を仮想中心として，仮想中心と各重心座標との平均距離を頭部動揺値と定義して用いた．体幹動揺の安定性評価についても同様の計算を行い，体幹動揺値と定義して用いた．足底圧荷重分布は足底圧分布測定システムを用いて計測した．足底圧荷重分布の安定性評価の定量的指標には，足底圧荷重中心移動の総軌跡長と面積を用いた．
  立位における頭部動揺値と体幹動揺値は，下顎安静位，咬頭嵌合位，グミ咀嚼の順に小さくなった．足底圧荷重中心移動の総軌跡長と面積は，下顎安静位，咬頭嵌合位，グミ咀嚼の順に，それぞれ短く，かつ小さくなった．立位におけるグミ咀嚼時には，頭部動揺と体幹動揺，頭部動揺と足底圧荷重分布，体幹動揺と足底圧荷重分布それぞれの間に正の相関が認められた．これらの結果から，立位では，下顎安静位，咬頭嵌合位を保持した時と比較して，グミ咀嚼時には，頭部動揺，体幹動揺，足底圧荷重分布がすべて小さくなり，それぞれの動揺が相関をもって姿勢の安定性に関係することが明らかとなった．
  日本学術振興会, 基盤研究(C), 北海道大学, 23K09286
• Elucidation of interrelationship and consequence between postural control, stomatognathic and body functions using biomechanical techniques
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  Apr. 2019 - Mar. 2022
  坂口 究; 横山 敦郎
  初年度は，ヒトが咀嚼を行う一般的な姿勢である座位において，咀嚼が姿勢制御に影響を及ぼし，姿勢の安定性を高める可能性があることを明らかにした．一方，座位姿勢の変化が咀嚼能力に及ぼす影響についての報告は少なく，十分には解明されていなかった．顎口腔機能と姿勢制御の相互連関性を解明するうえで，「顎口腔機能が姿勢に及ぼす影響」のみならず，「姿勢の変化が顎口腔機能に及ぼす影響」についても検討することはきわめて有意義である．
  本年度は，姿勢の変化が咀嚼能力に及ぼす影響について明らかにすることを目的とした．足底接地の座位姿勢（両足底が床面に全面接地した端座位）と足底非接地の座位姿勢（両足底が床面から浮いた端座位）の2つの姿勢の条件下において，グミ咀嚼時における頭部運動，体幹運動，座圧荷重分布および咀嚼能力の測定を行った．その結果，1．足底接地の座位姿勢における頭部動揺値，体幹動揺値，ならびに平均中心変位は，足底非接地の座位姿勢時と比較してそれぞれ小さかった（p<0.05）．2．足底接地の座位姿勢におけるグルコース溶出量は，足底非接地の座位姿勢時と比較して多かった（p<0.01）．これらの結果から，咀嚼時の座位姿勢は，足底が接地しているほうが非接地と比較して安定していることが示された．また，足底接地の座位姿勢における咀嚼能力は，足底非接地の座位姿勢時と比較して高いことがわかった．
  以上のことから，足底接地の座位姿勢における咀嚼時には，足底非接地の座位姿勢時と比較して，姿勢の安定化が図られるとともに，高い咀嚼能力を発揮することが明らかとなった．すなわち，座位姿勢の変化は，咀嚼能力に影響を及ぼすことが示唆された．
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 19K10219
• Comprehensive approaches for the interrelationship between dental occlusion, masticatory function and body posture
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  01 Apr. 2015 - 31 Mar. 2018
  SAKAGUCHI KIWAMU; Mehta Noshir; MARUYAMA Tomoaki; CHINO Keisuke
  The purpose of this study was to examine the effect of masticatory movements on the postural control in sitting posture. When subjects masticated gummy jelly with sitting position, head sway during mastication was larger than it in the rest position and centric occlusion (p<0.05), trunk sway during mastication was smaller than it in the two mandibular positions (p<0.05), while fluctuations of the lower limbs during mastication was showing a tendency to increase compared to those in the two mandibular positions. There were found to have correlations in head and trunk sways, seat and plantar pressure distributions during mastication (p<0.05). These findings suggest that masticatory movements affect the postural control by enhancing the postural stability during sitting position, evoking the interrelationship between movements of head, trunk and lower limbs.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 15K11188
• Comprehensive analysis of the interrelationship between dental occlusion, masticatory function and whole-body posture
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  2012 - 2012
  SAKAGUCHI KIWAMU; YOKOYAMA Atsuro; MEHTA Noshir; MARUYAMA Tomoaki; MAEDA Nozomi; SHIMA Keiko; ABE Kenichi; AZUMA Teruaki
  The purpose of this study was to evaluate to the effect of masticatory movements on head, trunk and body sways during standing position. When subjects maintained standing position with masticating chewing gum, head, trunk and body sways were significantly smaller than when they maintained their mandibles in the rest position and centric occlusion (p<0.05). No significant differences were found in the weight distribution between the 2 mandibular positions and masticating chewing gum. It was founded that masticating chewing gum affected the stability of head, trunk and body sways during standing position. These findings suggest that masticatory movements affect the postural control by enhancing the postural stability during standing position.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, Competitive research funding, 24592893
• Examination of the relationship among dental occlusion, body posture, body sway and the general health of the body using time-series analyses
  Grants-in-Aid for Scientific Research(基盤研究(C))
  2008 - 2010
  Kiwamu SAKAGUCHI; Atsuro YOKOYAMA; Mehta NOSHIR; Nozomi MAEDA; Tomoaki MARUYAMA; Teruaki AZUMA
  We built the simultaneous measurements of body sway and head position, and those of the electromyographic (EMG) activity of craniocervical muscles and dental occlusion in order to establish the methodology for the quantitative evaluation elucidating the interrelationship between stomatognathic function and the general health of the body. The result of our examination clearly showed that there was a significant correlation between body posture, head position and dental occlusion. Moreover, we were able to establish the methodology for the quantitative evaluation elucidating the interrelation...
  Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(C), 北海道大学, Principal investigator, Competitive research funding, 20592252
• Classification of edentulous mandibular alveolar ridges based on the finite element analysis on the dynamic behavior of the complete dentures.
  Grants-in-Aid for Scientific Research(基盤研究(C))
  2003 - 2004
  Yoshiyuki TAKAYAMA; 川崎 貴生; 坂口 究
  The purpose of this study was twofold : development of a new method to make finite element model from digitized 3-dimensional shape of the alveolar ridge and a wax denture automatically as much as possible, and classification of the mandibular alveolar ridge based on the dynamic behavior of the denture calculated by finite element method.We measured three-dimensional shape of a master cast and a wax denture with 3D laser scanner LPX-250 (Roland DG Co.Ltd.). It was posssible to make FE model quasi-automatically with a software we developed in C++ programming language. The FE models was consi...
  Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(C), 北海道大学, Coinvestigator not use grants, Competitive research funding, 15592039
• MEMスペクトル解析による咀嚼機能および顎口腔機能評価
  科学研究費補助金(若手研究(B))
  2002 - 2003
  坂口 究
  まずは、現有システムのバージョンアップを図った。具体的には、現有パソコンにリアルタイム3次元座標計測ソフト(ライブラリー・Radish)を搭載することにより、3次元計測のリアルタイム化が可能となった。得られる計測値とこれまでの計測結果との精度検定を行ったところ、左右・上下方向成分で1/1000mm、前後方向成分で1/100mmオーダーの誤差が確認された。しかし、咀嚼運動解析結果の検証を行ったところ、これまでの報告と同様の結果が得られ、リアルタイム化に伴う影響は無かった。次に、咀嚼運動時の下顎運動と下顔面皮膚上の運動の時系列データに対して、MEMスペクトル解析(ジー・エム・エス・MemCalc/Win)を行った。1.下顎運動咀嚼運動のspectrumで最も大きなpowerを示すmaximum peakが出現する周波数は、これまでの時間領域における咀嚼周期の報告と比較検討した結果、ほぼ同じであった。このことから、maximum peakが出現する周波数は、咀嚼運動の最も基本的な周波数である咀嚼周期と考えられる。また、spectrumのpeakは、maximum peakの高周波域にみられたが、低周波域には認められなかった。2.下顔面皮膚上の運動下顎運動のspectrumとは異なり、maximum peakの低周波域と高周波域にたくさんの側帯域波が認められた。しかし、maximum...
  文部科学省, 若手研究(B), 北海道大学, Principal investigator, Competitive research funding, 14771075
• 咀嚼運動時の下顔面皮膚表面の時空間的構造解析による顎口腔機能評価
  科学研究費補助金(奨励研究(A))
  2000 - 2001
  坂口 究
  これまで、咀嚼時における下顔面皮膚上の動態解析を行い、その咀嚼運動評価法としての有効性を報告してきた。そして、健常有歯顎者の習慣性咀嚼側における咀嚼では、下顔面皮膚上の運動は下顎運動と協調し、運動周期は同じであるが運動パターンは測定点によって異なることを明らかにした。しかし、咀嚼運動の巧緻性は、健常者であれば非習慣性咀嚼側であっても存在すると考えられるが、それを咀嚼側間で比較した研究は極めて少なく、下顔面皮膚上の運動解析に至っては皆無である。そこで本研究では、個体内における咀嚼時下顔面皮膚上の運動巧緻性を咀嚼側間で比較することにより、その運動機能的差異を評価することとした。解析パラメータとして、時間的評価に咀嚼周期を、そして、空間的評価に測定点間の咀嚼経路の平均2乗誤差と平均差分ベクトルを用いた。咀嚼側間における各パラメータの有意差検定は、ウイルコクソン順位和検定(p<0.01)を行った。その結果、それぞれの咀嚼側における下顔面皮膚上の運動は、時間的に安定しており、かつ下顎運動と同じく正確なリズムで協調していることが分かった。空間的には、運動の経路と方向の類似性(運動パターン)が安定しており、咀嚼側間で鏡像関係にあることが分かった。さらに、咀嚼側間での運動安定性の評価を行ったところ、時間的に有意差はなく、空間的にも運動経路と方向の安定性に有意差はなかった。以上のことから、個体...
  文部科学省, 奨励研究(A), 北海道大学, Principal investigator, Competitive research funding, 12771164
• Time series analyses on the mandibular and perioral soft tissue movement during the mastication
  Grants-in-Aid for Scientific Research(基盤研究(B))
  1999 - 2001
  Takao KAWASAKI; 山田 亨; 坂口 究; 高山 芳幸
  Though the research on the chewing movement is large in number, the most is the research on the jaw movement. The movement of tongue and buccal mucosa that cooperated for the lower jaw movement accompanies the mastication. So, we analyzed that movement in order to utilize the movement of the skin for the mastication function evaluation during mastication.We concluded the followings;(l) Over 95 % of perioral soft tissue movements can be expressed by PCA using the first three PCs. (2) The movements of mandibular and perioral soft tissue were closely related in the first and third PC. (3) The ...
  Ministry of Education, Culture, Sports, Science and Technology, 基盤研究(B), 北海道大学, Coinvestigator not use grants, Competitive research funding, 11470410