SEARCH
Search Details
Kato Izumi
| Faculty of Pharmaceutical Sciences Education Research Center for Clinical Pharmacy | Assistant Professor |
Researcher basic information
■ Degree■ URL
researchmap URL■ Various IDs
J-Global ID■ Research Keywords and Fields
Research KeywordResearch Field■ Educational Organization
- Bachelor's degree program, School of Pharmaceutical Sciences and Pharmacy
- Master's degree program, Graduate School of Life Science
- Doctoral (PhD) degree program, Graduate School of Life Science
Research activity information
■ Papers- Automating the roter interaction analysis system for medication counseling: A transformer-based deep learning approach with generative AI-augmented data
Ayako Mori; Satoshi Watabe; Izumi Kato; Katsuya Narumi; Yoh Takekuma; Hayato Kizaki; Shungo Imai; Keisuke Okamoto; Hinata Ueda; Mitsuru Sugawara; Satoko Hori; Masaki Kobayashi
Research in Social and Administrative Pharmacy, Elsevier BV, Jun. 2026, [Peer-reviewed]
Scientific journal - Corrigendum to "Quantitative analysis of communication changes in online medication counseling using the Roter Interaction System" [Res Soc Adm Pharm 20 (2024) 36-42].
Ayako Mori; Izumi Kato; Katsuya Narumi; Yoh Takekuma; Hitoshi Kashiwagi; Yuki Sato; Mitsuru Sugawara; Masaki Kobayashi
Research in social & administrative pharmacy : RSAP, 19 Dec. 2025, [Peer-reviewed], [International Magazine]
English - A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells.
Yoichiro Fujioka; Shinya Nishide; Toyoyuki Ose; Tadaki Suzuki; Izumi Kato; Hideo Fukuhara; Mari Fujioka; Kosui Horiuchi; Aya O Satoh; Prabha Nepal; Sayaka Kashiwagi; Jing Wang; Mika Horiguchi; Yuko Sato; Sarad Paudel; Asuka Nanbo; Tadaaki Miyazaki; Hideki Hasegawa; Katsumi Maenaka; Yusuke Ohba
Cell host & microbe, 23, 6, 809, 818, 13 Jun. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Influenza A virus (IAV) infection is initiated by the attachment of the viral glycoprotein hemagglutinin (HA) to sialic acid on the host cell surface. However, the sialic acid-containing receptor crucial for IAV infection has remained unidentified. Here, we show that HA binds to the voltage-dependent Ca2+ channel Cav1.2 to trigger intracellular Ca2+ oscillations and subsequent IAV entry and replication. IAV entry was inhibited by Ca2+ channel blockers (CCBs) or by knockdown of Cav1.2. The CCB diltiazem also inhibited virus replication in vivo. Reintroduction of wild-type but not the glycosylation-deficient mutants of Cav1.2 restored Ca2+ oscillations and virus infection in Cav1.2-depleted cells, demonstrating the significance of Cav1.2 sialylation. Taken together, we identify Cav1.2 as a sialylated host cell surface receptor that binds HA and is critical for IAV entry. - Secretion of Legumain Increases in Conditioned Medium from DJ-1-Knockout Cells and in Serum from DJ-1-Knockout Mice
Takuya Yamane; Izumi Kato-Ose; Tatsuji Sakamoto; Yoshihisa Nakano
Open Biochem. J., 12, 29, 35, 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: Asparaginyl endopeptidase, also known as legumain (EC 3.4.22.34) shows strong activity in the mouse kidney. Legumain is also highly expressed in tumors. DJ-1/PARK7 is a Parkinson's disease- and cancer-associated protein. DJ-1 is a coactivator of various transcription factors. Recently, we reported that transcription of the legumain gene is regulated by p53 through DJ-1. Methods: We measured the secretion levels of legumain in a conditioned medium of DJ-1 knockout cells and in serum from DJ-1 knockout mice using Western blotting and ELISA. We performed immunocytochemical staining of legumain to examine the localization of legumain in DJ-1-knockout cells. Results: We found that the secretion levels of legumain were increased in the conditioned medium of DJ-1-knockout cells and in serum from DJ-1-knockout mice. Dot structures of legumain were also increased in DJ-1-knockout cells. Conclusion: The results suggest that legumain secretion from DJ-1-knockout cells and in mice increases through its increased expression and accumulation in membrane-associated vesicles. - DJ-1 activates SIRT1 through its direct binding to SIRT1
Kazuko Takahashi-Niki; Yoko Ganaha; Takeshi Niki; Shota Nakagawa; Izumi Kato-Ose; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 474, 1, 131, 136, May 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal - Epidermal Growth Factor-dependent Activation of the Extracellular Signal-regulated Kinase Pathway by DJ-1 Protein through Its Direct Binding to c-Raf Protein
Kazuko Takahashi-Niki; Izumi Kato-Ose; Hiroaki Murata; Hiroshi Maita; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 29, 17838, 17847, Jul. 2015, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal - Transcriptional regulation of the legumain gene by p53 in HCT116 cells
Takuya Yamane; Sato Murao; Izumi Kato-Ose; Lisa Kashima; Motoki Yuguchi; Miyuki Kozuka; Keisuke Takeuchi; Hisakazu Ogita; Iwao Ohkubo; Hiroyoshi Ariga
Biochemical and Biophysical Research Communications, 438, 4, 613, 618, 06 Sep. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - Identification of DJ-1-associated regions on human genes from SH-SY5Y cells using chromatin immunoprecipitation sequence technique
Takuya Yamane; Naoyuki Sugimoto; Hiroshi Maita; Kazufumi Watanabe; Kazuko Takahashi-Niki; Chinatsu Maita; Izumi Kato-Ose; Shizuma Ishikawa; Jian-Wei Gao; Hirotake Kitaura; Takeshi Niki; Sanae M.M. Iguchi-Ariga; Hiroyoshi Ariga
Mol. Biol., 3, 15, OMICS International, 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal, DJ-1, a cancer- and Parkinson's disease-associated protein, works as a coactivator to various transcription factors. In this study, DNA fragments that bind to DJ-1 complexes were obtained by a chromatin immunoprecipitation sequencing with an anti-human DJ-1 antibody using chromatin from SH-SY5Y cells. We identified 60 different sequences as potential DJ-1 complex-binding sites in genes. Of sequences identified, expression levels of DJ-1-associated sitecontaining genes for DNA polymerase N, estrogen receptor α and S-adenosylhomocysteine hydrolase like-2 were decreased in DJ-1-knockdown cells and in 6-OHDA-treated cells. These studies suggest that DJ-1 regulates the expression of versatile genes at the transcriptional level and that some of the genes are regulated by DJ-1 in an oxidative status-dependent manner - Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner
Izumi Kato; Hiroshi Maita; Kazuko Takahashi-Niki; Yoshiro Saito; Noriko Noguchi; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
MOLECULAR AND CELLULAR BIOLOGY, 33, 2, 340, 359, Jan. 2013, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal - Neuroprotective function of dj-1 in Parkinson's disease
Hiroyoshi Ariga; Kazuko Takahashi-Niki; Izumi Kato; Hiroshi Maita; Takeshi Niki; Sanae M. M. Iguchi-Ariga
Oxidative Medicine and Cellular Longevity, 2013, 683920, 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis
Shiori Yamaguchi; Takuya Yamane; Kazuko Takahashi-Niki; Izumi Kato; Takeshi Niki; Matthew S. Goldberg; Jie Shen; Kenji Ishimoto; Takefumi Doi; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
PLOS ONE, 7, 5, e38144, May 2012, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Scientific journal
- 成人T細胞白血病細胞に細胞死を誘導する新規モノクローナル抗体の分子認識機構
露木貴浩; PABLO Adrian Guillen Poza; 加藤いづみ; 喜多俊介; 長郷巧太; 鷲見正人; 黒木喜美子; 前仲勝実; 前仲勝実; 前仲勝実; 前仲勝実; 前田直良; 前田直良, 日本蛋白質科学会年会(Web), 25th, 2025 - Antigen recognition mechanism of monoclonal antibodies that induce cell death in adult T-cell leukemia cells
露木貴浩; 長郷巧太; POZA Pablo Adrian Guillen; 加藤いづみ; 喜多俊介; 鷲見正人; 黒木喜美子; 前仲勝実; 前仲勝実; 前仲勝実; 前仲勝実; 前田直良; 前田直良, 日本薬学会年会要旨集(Web), 145th, 2025 - The antigen recognition mechanism of antibodies recognizing adult T-cell leukemia cells
長郷巧太; 露木貴浩; POZA Pablo Adrian Guillen; 加藤いづみ; 喜多俊介; 鷲見正人; 黒木喜美子; 前仲勝実; 前仲勝実; 前仲勝実; 前仲勝実; 前田直良, 日本薬学会年会要旨集(Web), 145th, 2025 - 成人T細胞白血病細胞増殖抑制抗体の抗原ペプチド認識の構造基盤
露木貴浩; GUILLEN POZA Pablo Adrian; 加藤いづみ; 喜多俊介; 長郷巧太; 鷲見正人; 黒木喜美子; 前仲勝実; 前仲勝実; 前仲勝実; 前仲勝実; 前田直良; 前田直良, 日本蛋白質科学会年会(Web), 24th, 2024 - HMG-CoAレダクダーゼ活性を阻害するアロニア果汁含有成分の同定
小塚 美由記; 山根 拓也; 今井 ももこ; 加藤 いづみ; 石井 哲夫; 竹中 重雄; 坂本 龍司; 乾 博; 山本 好男; 大久保 岩男; 中垣 剛典; 中野 長久, 日本生化学会大会プログラム・講演要旨集, 91回, [3P, 253], Sep. 2018
(公社)日本生化学会, Japanese - インフルエンザウイルス細胞侵入において鍵となる宿主タンパク質の同定
藤岡 容一朗; 西出 真也; 尾瀬 農之; 加藤 いづみ; 福原 秀雄; 藤岡 真理; 堀内 浩水; 佐藤 絢; Nepal Prabha; 柏木 彩花; Wang Jing; 堀口 美香; Paudel Sarad; 南保 明日香; 宮崎 忠昭; 前仲 勝実; 大場 雄介, 日本細胞生物学会大会講演要旨集, 69回, 61, 61, May 2017
(一社)日本細胞生物学会, Japanese - インフルエンザウイルス細胞侵入において鍵となる宿主タンパク質の同定
藤岡容一朗; 西出真也; 尾瀬農之; 加藤いづみ; 福原秀雄; 藤岡真理; 堀内浩水; 佐藤絢; NEPAL Prabha; 柏木彩花; WANG Jing; 堀口美香; PAUDEL Sarad; 南保明日香; 宮崎忠昭; 前仲勝実; 前仲勝実; 大場雄介, 日本細胞生物学会大会(Web), 69th, ROMBUNNO.T8‐04(P2‐028) (WEB ONLY), 61, May 2017
(一社)日本細胞生物学会, Japanese - Oxidative status of DJ-1-dependent regulation of the p53 signaling
Izumi Kato; Hiroshi Maita; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga, NEUROSCIENCE RESEARCH, 68, E307, E307, 2010
English, Summary international conference
