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西岡　典子 (ニシオカ　ノリコ)

北海道大学病院助教

研究者基本情報

■ 学位
  • 学士（医学）, 北海道大学, 2005年03月
  • 博士（医学）, 北海道大学, 2025年03月
■ URL
researchmap URLホームページURL■ ID 各種
ORCID IDJ-Global ID■ 研究キーワード・分野
研究キーワード
  • MRI
  • 画像診断学
研究分野
  • ライフサイエンス, 放射線科学

経歴

■ 経歴
経歴
  • 2025年04月 - 現在
    北海道大学病院, 核医学診療科, 助教, 日本国

研究活動情報

■ 受賞
  • 2024年10月, 日本医学放射線学会, 優秀賞
    第60回日本医学放射線学会秋季臨床大会
■ 論文
  • 前立腺T2WIにおける深層学習再構成の画質改善と撮像時間短縮
    西岡 典子; 藤間 憲幸; 常田 慧徳; 坂本 圭太; 濱口 裕行; 松本 隆児; 工藤 與亮
    日本医学放射線学会秋季臨床大会抄録集, 61回, S449, S449, (公社)日本医学放射線学会, 2025年09月
    日本語
  • Comparative evaluation of four reconstruction techniques for prostate T2-weighted MRI: Sensitivity encoding, compressed sensing, deep learning, and super-resolution
    Noriko Nishioka; Noriyuki Fujima; Satonori Tsuneta; Daisuke Kato; Takashi Kamiishi; Masato Yoshikawa; Rina Kimura; Keita Sakamoto; Ryuji Matsumoto; Takashige Abe; Jihun Kwon; Masami Yoneyama; Kohsuke Kudo
    European Journal of Radiology Open, 2025年07月, ［査読有り］, ［筆頭著者, 責任著者］
    英語, 研究論文（学術雑誌）
  • The Impact of Model-based Deep-learning Reconstruction Compared with that of Compressed Sensing-Sensitivity Encoding on the Image Quality and Precision of Cine Cardiac MR in Evaluating Left-ventricular Volume and Strain: A Study on Healthy Volunteers.
    Satonori Tsuneta; Satoru Aono; Rina Kimura; Jihun Kwon; Noriyuki Fujima; Kinya Ishizaka; Noriko Nishioka; Masami Yoneyama; Fumi Kato; Kazuyuki Minowa; Kohsuke Kudo
    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2025年05月30日, ［査読有り］, ［国内誌］
    英語, 研究論文（学術雑誌）, PURPOSE: To evaluate the effect of model-based deep-learning reconstruction (DLR) compared with that of compressed sensing-sensitivity encoding (CS) on cine cardiac magnetic resonance (CMR). METHODS: Cine CMR images of 10 healthy volunteers were obtained with reduction factors of 2, 4, 6, and 8 and reconstructed using CS and DLR. The visual image quality scores assessed sharpness, image noise, and artifacts. Left-ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) were manually measured. LV global circumferential strain (GCS) was automatically measured using the software. The precision of EDV, ESV, SV, EF, and GCS measurements was compared between CS and DLR using Bland-Altman analysis with full-sampling data as the gold standard. RESULTS: Compared with CS, DLR significantly improved image quality with reduction factors of 6 and 8. The precision of EDV and ESV with a reduction factor of 8, and GCS with reduction factors of 6 and 8 measurements improved with DLR compared with CS, whereas those of SV and EF measurements were not different between DLR and CS. CONCLUSION: The effect of DLR on cine CMR's image quality and precision in evaluating quantitative volume and strain was equal or superior to that of CS. DLR may replace CS for cine CMR.
  • Accelerating FLAIR imaging via deep learning reconstruction: potential for evaluating white matter hyperintensities
    Noriko Nishioka; Yukie Shimizu; Yukio Kaneko; Toru Shirai; Atsuro Suzuki; Tomoki Amemiya; Hisaaki Ochi; Yoshitaka Bito; Masahiro Takizawa; Yohei Ikebe; Hiroyuki Kameda; Taisuke Harada; Noriyuki Fujima; Kohsuke Kudo
    Japanese Journal of Radiology, 2024年09月, ［査読有り］, ［筆頭著者］
    英語, 研究論文（学術雑誌）
  • Enhancing the image quality of prostate diffusion-weighted imaging in patients with prostate cancer through model-based deep learning reconstruction.
    Nishioka N; Fujima N; Tsuneta S; Yoshikawa M; Kimura R; Sakamoto K; Kato F; Miyata H; Kikuchi H; Matsumoto R; Abe T; Kwon J; Yoneyama M; Kudo K
    European journal of radiology open, 2024年07月05日, ［査読有り］, ［筆頭著者］
    英語, 研究論文（学術雑誌）,

    Purpose

    To evaluate the utility of model-based deep learning reconstruction in prostate diffusion-weighted imaging (DWI).

    Methods

    This retrospective study evaluated two prostate diffusion-weighted imaging (DWI) methods: deep learning reconstruction (DL-DWI) and traditional parallel imaging (PI-DWI). We examined 32 patients with radiologically diagnosed and histologically confirmed prostate cancer (PCa) lesions ≥10 mm. Image quality was evaluated both qualitatively (for overall quality, prostate conspicuity, and lesion conspicuity) and quantitatively, using the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and apparent diffusion coefficient (ADC) for prostate tissue.

    Results

    In the qualitative evaluation, DL-DWI scored significantly higher than PI-DWI for all three parameters (p<0.0001). In the quantitative analysis, DL-DWI showed significantly higher SNR and CNR values compared to PI-DWI (p<0.0001). Both the prostate tissue and the lesions exhibited significantly higher ADC values in DL-DWI compared to PI-DWI (p<0.0001, p=0.0014, respectively).

    Conclusion

    Model-based DL reconstruction enhanced both qualitative and quantitative aspects of image quality in prostate DWI. However, this study did not include comparisons with other DL-based methods, which is a limitation that warrants future research.
  • Comparison of Echo-Planar Imaging and Compressed Sensing in the Estimation of Flow Metrics from Aortic 4D Flow MR Imaging: A Healthy Volunteer Study.
    Aono S; Tsuneta S; Nishioka N; Aoike T; Hirayama H; Ishizaka K; Jihun Kwon; Yoneyama M; Fujima N; Kudo K
    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2024年03月29日, ［査読有り］
    研究論文（学術雑誌）,

    Purpose

    Prolonged scanning of time-resolved 3D phase-contrast MRI (4D flow MRI) limits its routine use in clinical practice. An echo-planar imaging (EPI)-based sequence and compressed sensing can reduce the scan duration. We aimed to determine the impact of EPI for 4D flow MRI on the scan duration, image quality, and quantitative flow metrics.

    Methods

    This was a prospective study of 15 healthy volunteers (all male, mean age 33 ± 5 years). Conventional sensitivity encoding (SENSE), EPI with SENSE (EPI), and compressed SENSE (CS) (reduction factors: 6 and 12, respectively) were scanned.Scan duration, qualitative indexes of image quality, and quantitative flow parameters of net flow volume, maximum flow velocity, wall shear stress (WSS), and energy loss (EL) in the ascending aorta were assessed. Two-dimensional phase-contrast cine MRI (2D-PC) was considered the gold standard of net flow volume and maximum flow velocity.

    Results

    Compared to SENSE, EPI and CS12 shortened scan durations by 71% and 73% (EPI, 4 min 39 sec; CS6, 7 min 29 sec; CS12, 4 min 14 sec; and SENSE, 15 min 51 sec). Visual image quality was significantly better for EPI than for SENSE and CS (P < 0.001). The net flow volumes obtained with SENSE, EPI, and CS12 and those obtained with 2D-PC were correlated well (r = 0.950, 0.871, and 0.850, respectively). However, the maximum velocity obtained with EPI was significantly underestimated (P < 0.010). The average WSS was significantly higher with EPI than with SENSE, CS6, and CS12 (P < 0.001, P = 0.040, and P = 0.012, respectively). The EL was significantly lower with EPI than with CS6 and CS12 (P = 0.002 and P = 0.007, respectively).

    Conclusion

    EPI reduced the scan duration, improved visual image quality, and was associated with more accurate net flow volume than CS. However, the flow velocity, WSS, and EL values obtained with EPI and other sequences may not be directly comparable.
  • Automated Detection of Cerebral Microbleeds on Two-dimensional Gradient-recalled Echo T2* Weighted Images Using a Morphology Filter Bank and Convolutional Neural Network.
    Nishioka N; Shimizu Y; Shirai T; Ochi H; Yoshitaka Bito; Watanabe K; Kameda H; Harada T; Kudo K
    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2024年03月15日, ［査読有り］, ［筆頭著者］
    英語, 研究論文（学術雑誌）,

    Purpose

    We present a novel algorithm for the automated detection of cerebral microbleeds (CMBs) on 2D gradient-recalled echo T2* weighted images (T2*WIs). This approach combines a morphology filter bank with a convolutional neural network (CNN) to improve the efficiency of CMB detection. A technical evaluation was performed to ascertain the algorithm's accuracy.

    Methods

    In this retrospective study, 60 patients with CMBs on T2*WIs were included. The gold standard was set by three neuroradiologists based on the Microbleed Anatomic Rating Scale guidelines. Images with CMBs were extracted from the training dataset comprising 30 cases using a morphology filter bank, and false positives (FPs) were removed based on the threshold of size and signal intensity. The extracted images were used to train the CNN (Vgg16). To determine the effectiveness of the morphology filter bank, the outcomes of the following two methods for detecting CMBs from the 30-case test dataset were compared: (a) employing the morphology filter bank and additional FP removal and (b) comprehensive detection without filters. The trained CNN processed both sets of initial CMB candidates, and the final CMB candidates were compared with the gold standard. The sensitivity and FPs per patient of both methods were compared.

    Results

    After CNN processing, the morphology-filter-bank-based method had a 95.0% sensitivity with 4.37 FPs per patient. In contrast, the comprehensive method had a 97.5% sensitivity with 25.87 FPs per patient.

    Conclusion

    Through effective CMB candidate refinement with a morphology filter bank and FP removal with a CNN, we achieved a high CMB detection rate and low FP count. Combining a CNN and morphology filter bank may facilitate the accurate automated detection of CMBs on T2*WIs.
  • 低血糖発作を合併した胸膜孤立性線維性腫瘍の1例
    村本 朋之; 中川 純一; 常田 慧徳; 高橋 文也; 木村 理奈; 西岡 典子; 坂本 圭太; 加藤 扶美; 氏家 秀樹; 加藤 達哉; 大藤 悠里; 亀田 啓; 中村 昭伸; 若林 健人; 松野 吉宏; 工藤 與亮
    Japanese Journal of Radiology, 42, Suppl., 4, 4, (公社)日本医学放射線学会, 2024年02月
    日本語
  • Gastrointestinal: Solid pseudopapillary neoplasm of the pancreas with high-grade malignant transformation.
    Naoto Wakabayashi; Rina Kimura; Masaki Kuwatani; Aya Matsui; Ino N; Mitsuhashi T; Kazuma Kishi; Satonori Tsuneta; Nakagawa J; Nishioka N; Sakamoto K; Fumi Kato; Shimizu A; Satoshi Hirano; Kohsuke Kudo
    Journal of gastroenterology and hepatology, 2024年01月15日, ［査読有り］
    英語, 研究論文（学術雑誌）
  • Clinical utility of single-shot echo-planar diffusion-weighted imaging using L1-regularized iterative sensitivity encoding in prostate MRI.
    Nishioka N; Fujima N; Noriyuki Fujima; Tsuneta S; Yoneyama M; Matsumoto R; Abe T; Kimura R; Sakamoto K; Kato F; Kudo K
    Medicine, 2023年04月01日, ［査読有り］, ［筆頭著者］
    英語, 研究論文（学術雑誌）, We investigated the ability of echo-planar imaging with L1-regularized iterative sensitivity encoding-based diffusion-weighted imaging (DWI) to improve the image quality and reduce the scanning time in prostate magnetic resonance imaging. We retrospectively analyzed 109 cases of prostate magnetic resonance imaging. We compared variables in the quantitative and qualitative assessments among 3 imaging groups: conventional parallel imaging-based DWI (PI-DWI) with an acquisition time of 3 minutes 15 seconds; echo-planar imaging with L1-regularized iterative sensitivity encoding-based DWI (L1-DWI) with a normal acquisition time (L1-DWINEX12) of 3 minutes 15 seconds; and L1-DWI with a half acquisition time (L1-DWINEX6) of 1 minute 45 seconds. As a quantitative assessment, the signal-to-noise ratio (SNR) of DWI (SNR-DWI), the contrast-to-noise ratio (CNR) of DWI (CNR-DWI), and the CNR of apparent diffusion coefficient were measured. As a qualitative assessment, the image quality and visual detectability of prostate carcinoma were evaluated. In the quantitative analysis, L1-DWINEX12 showed significantly higher SNR-DWI than PI-DWI (P = .0058) and L1-DWINEX6 (P < .0001). In the qualitative analysis, the image quality score for L1-DWINEX12 was significantly higher than those of PI-DWI and L1-DWINEX6. A non-inferiority assessment demonstrated that L1-DWINEX6 was non-inferior to PI-DWI in terms of both quantitative CNR-DWI and qualitative grading of image quality with a <20% inferior margin. L1-DWI successfully demonstrated a reduced scanning time while maintaining good image quality.
  • Estimation of Amyloid-β Positivity Using QSM Images Considering Age Information.
    Tsubasa Kunieda; Ren Togo; Noriko Nishioka; Yukie Shimizu; Shiro Watanabe; Kenji Hirata; Keisuke Maeda; Takahiro Ogawa 0001; Kohsuke Kudo; Miki Haseyama
    ICCE-Taiwan, 165, 166, 2023年
    研究論文（国際会議プロシーディングス）
  • Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy.
    Ueki Masahiro; Sakamoto K; Nishioka N; Ohata H; Nobuta T; Takezaki S; Manabe A; Yamada M
    Modern rheumatology case reports, 2023年01月01日, ［査読有り］
    英語, 研究論文（学術雑誌）, Symptomatic vitamin C deficiency, scurvy, is a relatively rare disease in developed countries, but it has been reported in patients with autism spectrum disorder or developmental delay who tend to have selective diets. Patients with scurvy often demonstrate musculoskeletal manifestations with unknown pathophysiology. Herein, we report a case of scurvy in an 11-year-old boy who presented with iron-deficiency anaemia, systemic osteomyelitis, myositis predominantly in the lower extremities, and right ventricular volume overload with mild pulmonary hypertension and was diagnosed with scurvy. He had a mild developmental disorder and a selective diet, which resulted in severe vitamin C deficiency. He received intravenous and oral vitamin C supplementation, which relieved his arthralgia and muscle pain in a week. Following 4 months of vitamin C supplementation, he demonstrated no abnormal manifestations on laboratory or imaging examination and recovered without sequelae. Inflammatory cytokine and chemokine evaluations demonstrated elevated levels of interleukin (IL)-6, IL-17A, and IL-23, which are associated with T-helper (Th) 17 cell activation. This study is the first to suggest the association between the inflammation seen in scurvy, rheumatic manifestations in the patient, and Th17 cell activation. Further analysis of the association between the inflammation and vitamin C supplementation may contribute to new insights for the comprehension and treatment of other inflammatory diseases, such as rheumatic diseases.
  • Prediction of Amyloid-β Positivity Using QSM Images Based on Bootstrap Your Own Latent.
    Tsubasa Kunieda; Ren Togo; Noriko Nishioka; Yukie Shimizu; Shiro Watanabe; Kenji Hirata; Keisuke Maeda; Takahiro Ogawa 0001; Kohsuke Kudo; Miki Haseyama
    GCCE, 137, 138, IEEE, 2022年
    研究論文（国際会議プロシーディングス）
  • Relationship between diseased lung tissues on computed tomography and motion of fiducial marker near lung cancer.
    Onodera Y; Nishioka N; Yasuda K; Fujima N; Torres M; Tamotsu Kamishima; Ooyama N; Rikiya Onimaru; Terae S; Ooizumi S; Masaharu Nishimura; Shirato H
    International journal of radiation oncology, biology, physics, 2010年06月03日, ［査読有り］
    英語, 研究論文（学術雑誌）,

    Purpose

    For lung cancer patients with poor pulmonary function because of emphysema or fibrosis, it is important to predict the amplitude of internal tumor motion to minimize the irradiation of the functioning lung tissue before undergoing stereotactic body radiotherapy.

    Methods and materials

    Two board-certified diagnostic radiologists independently assessed the degree of pulmonary emphysema and fibrosis on computed tomography scans in 71 patients with peripheral lung tumors before real-time tumor-tracking radiotherapy. The relationships between the computed tomography findings of the lung parenchyma and the motion of the fiducial marker near the lung tumor were investigated. Of the 71 patients, 30 had normal pulmonary function, and 29 had obstructive pulmonary dysfunction (forced expiratory volume in 1 s/forced vital capacity ratio of <70%), 6 patients had constrictive dysfunction (percentage of vital capacity <80%), and 16 had mixed dysfunction.

    Results

    The upper region was associated with smaller tumor motion, as expected (p = .0004), and the presence of fibrosis (p = .088) and pleural tumor contact (p = .086) were weakly associated with tumor motion. The presence of fibrotic changes in the lung tissue was associated with smaller tumor motion in the upper region (p <.05) but not in the lower region. The findings of emphysema and pulmonary function tests were not associated with tumor motion.

    Conclusion

    Tumors in the upper lung region with fibrotic changes have smaller motion than those in the upper region of the lungs without fibrotic changes. The tumor motion in the lower lung region was not significantly different between patients with and without lung fibrosis. Emphysema was not associated with the amplitude of tumor motion.
  • Intra-articular nodular fasciitis in the elbow joint, with an emphasis on MR imaging findings.
    Noriko Nishioka; Tamotsu Kamishima; Tatsuya Masuko; Kanako C. Kubota; Miki Komatsu; Norimasa Iwasaki; Takayuki Nojima; Tomoo Itoh; Ardene A. Harris; Akio Minami; Hiroki Shirato
    European Journal of Radiology Extra, 69, e33, e36, 2009年, ［査読有り］, ［筆頭著者］
    英語
■ その他活動・業績
■ 所属学協会
  • 北米放射線学会
  • 日本核医学会
  • 日本腹部放射線学会
  • 日本磁気共鳴学会
  • 日本医学放射線学会
■ 共同研究・競争的資金等の研究課題