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稲尾 翼 (イナオ タスク)
| 遺伝子病制御研究所 病因研究部門 | 特任助教 |
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- 91035732
研究キーワード研究分野
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■ 受賞- 2025年10月, 生理学研究所・北海道大学遺伝子病制御研究所ジョイントシンポジウム ベストディスカッサー賞
- 2024年09月, 音羽博次奨学基金
- 2022年05月, 日本計量生物学会年会若手優秀発表賞(学生会員部門)
- 2021年07月, 日本分類学会奨励賞
- 2020年11月, 日本分類学会優秀学生発表賞
- Associations between animal and plant protein intakes and the mortality and hospitalization of patients with chronic heart failure.
Tasuku Inao; Yoichi M Ito; Takashi Yokota; Arata Fukushima; Taisuke Ono; Takeshi Sota; Yoshiharu Kinugasa; Masashige Takahashi; Ryuichi Matsukawa; Ichiro Yoshida; Shigeo Kakinoki; Kazuya Yonezawa; Yoshihiro Himura; Isao Yokota; Kazuhiro Yamamoto; Miyuki Tsuchihashi-Makaya; Shintaro Kinugawa
Clinical nutrition ESPEN, 103307, 103307, 2026年04月29日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND & AIMS: Associations between dietary animal and plant protein intakes and the mortality and morbidity in non-HF (heart failure) populations have been reported, but no study has evaluated these intakes' association with adverse events in patients with HF. We determined the associations of chronic HF patients' intakes of animal and plant proteins with mortality and hospitalization. METHODS: This prospective study enrolled 146 patients with chronic HF who were treated between Dec. 2012 and Sept. 2014 at 10 hospitals across Japan. Their dietary intake information was collected at baseline by a validated brief self-administered diet-history questionnaire. The primary outcomes were (i) all-cause death and hospitalization and (ii) cardiac death and HF hospitalization. We divided the total HF cohort into high and low animal and plant protein intakes, using the cut-off values of 10.3% and 6.0% of total energy consumption for animal and plant protein respectively, based on the spline's trends. RESULTS: During the 1-year follow-up, six patients died and 28 patients were hospitalized. A multivariable analysis demonstrated that compared to a high plant protein intake, a low plant protein intake was associated with all-cause death and hospitalization with a 1.93 risk ratio (95% CI: 1.03-3.60); no significant association of animal protein intake with the primary outcomes was observed. The combination of high animal protein and low plant protein intake was associated with both primary outcomes. CONCLUSIONS: Dietary plant protein intake was inversely associated with all-cause mortality and hospitalization in patients with chronic HF. - Treatment Effects of Genital Mycoplasma Species in High-Risk Pregnant Individuals: A Retrospective Cohort Study.
Takashi Yoshimasu; Tasuku Inao; Tetsuya Kawakita
Cureus, 17, 11, e98095, 2025年11月, ［国際誌］
英語, 研究論文（学術雑誌）, Objective We aimed to estimate the causal effect of treatment for genital Mycoplasma species on preterm birth (PTB) and spontaneous abortion (SA). We also evaluated treatment effects separately for cases with co-infection of Ureaplasma and Mycoplasma species. Methods This was a retrospective observational cohort study at a single center. Singleton mothers with one or more risk factors for PTBs were screened and treated for genital Mycoplasma species. The treatment was repeated based on polymerase chain reaction (PCR) results after each course. We applied inverse probability treatment weighting, and risk differences (RDs) of the treatment effect on pregnancy outcomes were estimated with the generalized estimating equations. A combination of PTB and SA was used as the primary outcome. Secondary analysis was conducted, focusing on treatment for co-infection of both Mycoplasma and Ureaplasma species. Results From January 2014 to December 2020, 696 individuals tested positive for genital Mycoplasma species. Of the individuals, 566 were treated with azithromycin, whereas 62 were not. Among them, 269 received a second treatment, whereas 40 did not. The first treatment effect on PTB and SA was RD (95% CI) of 0.037 (-0.104, 0.178), and the second treatment effect was RD (95% CI) of -0.049 (-0.220, 0.123). When focusing on co-infection of Ureaplasma and Mycoplasma, the first effect was RD (95% CI) of -0.005 (-0.274, 0.264), and the second treatment effect was RD (95% CI) of -0.545 (-0.739, -0.350). Conclusions Routine treatment for genital Mycoplasma species is not recommended. However, the results suggest potential benefits in treating co-infections. - Estimating Future Obstetrics and Gynecology Workforce Needs in Japan.
Takashi Yoshimasu; Tasuku Inao; Isao Yokota
Cureus, 17, 1, e78269, 2025年01月, ［国際誌］
英語, 研究論文（学術雑誌）, Introduction The Ministry of Health, Labour, and Welfare of Japan (MHLW) introduced a regulation on physician overtime work in 2024, limiting overtime hours to a maximum of 960 annually. This regulation has raised concerns that the quality of medical care may decline. On the other hand, the shifting demographics of Japan, characterized by an aging population and declining birth rates, suggest a potential decrease in demand for obstetrics and gynecology (OBGYN) services in the future. In Japan, there is no feasible study regarding how many OBGYN doctors are currently lacking and how many of them will be necessary. Herein, we conduct simulations using Japanese insurance claims data to estimate the required number of OBGYN doctors. Methods This is a simulation study. We project future demand based on the current demand, working hours, and demographic changes. Using health insurance claims data, we estimate how many OBGYN doctors will be necessary in the future within the overtime work limit. Results The required number of doctors shows a declining trend that mirrors the declining population. Presently, there is a shortage of 1,500 doctors to comply with the 960-hour limit, and it is anticipated to be until 2040 or later before all doctors adhere to this limit. Several sensitivity analyses consistently support this trend. Conclusions Despite the existing shortage of obstetricians and gynecologists, future demands are expected to decrease. Inter-hospital and regional communication should be promoted for systemic innovations. - Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery.
Takahiro Abe; Tasuku Inao; Yasushige Shingu; Akira Yamada; Shingo Takada; Arata Fukushima; Noriko Oyama-Manabe; Isao Yokota; Satoru Wakasa; Shintaro Kinugawa; Takashi Yokota
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2024年12月17日, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: Sarcopenia and malnutrition often occur simultaneously in adults with cardiovascular diseases. Our objective was to determine the associations of preoperative sarcopenia and malnutrition with major adverse cardiac and cerebral events (MACCE) after cardiac surgery. METHODS: We retrospectively analyzed 154 consecutive patients who underwent elective cardiac surgery between January 2015 and June 2018 at two institutions in Japan. Sarcopenia and nutritional status were preoperatively assessed by bilateral psoas muscle volume index (PMVI) using CT scans and the prognostic nutritional index (PNI), respectively. RESULTS: The median age in the total cohort was 69 years, and 43% were women. Within 30 days after surgery, 20 patients developed in-hospital MACCE and 7 patients died of any cause. Low PMVI (<72.25 cm3/m2) and low PNI (<48.15) were each independent predictors of postoperative MACCE occurrence with odds ratios (95% confidence interval) of 3.58 (1.22-10.53) and 3.73 (1.25-11.09) when adjusted for age and sex, and 3.25 (1.07-9.87) and 3.27 (1.08-9.89) when adjusted for preoperative left ventricular ejection fraction, angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker, and anticoagulant. In addition, the combination of low PMVI and low PNI conferred the highest risk of in-hospital MACCE among the 4 groups (ie, the low PMVI, low PNI, low PMVI+low PNI, and neither low PMVI nor low PNI groups). CONCLUSIONS: Preoperative low PMVI and low PNI were respectively associated with 30-day in-hospital MACCE occurrence after cardiac surgery. Notably, coexistence of these reductions further enhanced the risk of postoperative MACCE. - Event-free survival at 36 months is a suitable endpoint for diffuse large B-cell lymphoma patients treated with immunochemotherapy: real-world evidence from the North Japan Hematology Study Group.
Koh Izumiyama; Tasuku Inao; Hideki Goto; Shinpei Harada; Hajime Senjo; Keito Suto; Junichi Hashiguchi; Reiki Ogasawara; Tomoyuki Saga; Tetsuyuki Igarashi; Kentaro Wakasa; Ikumi Kasahara; Yukari Takeda; Keisuke Yamaguchi; Akio Shigematsu; Mutsumi Takahata; Katsuya Fujimoto; Yoshihito Haseyama; Takahiro Nagashima; Hajime Sakai; Yasutaka Kakinoki; Mitsutoshi Kurosawa; Isao Yokota; Takanori Teshima
Haematologica, 2024年06月13日, ［国際誌］
英語, 研究論文（学術雑誌）, Information regarding follow-up duration after treatment for newly diagnosed diffuse large B-cell lymphoma (DLBCL) is important. However, a clear endpoint has yet to be established. We totally enrolled 2182 patients newly diagnosed with DLBCL between 2008 and 2018. The median age of the patients was 71 years. All patients were treated with rituximab- and anthracycline-based chemotherapies. Each overall survival (OS) was compared with the age- and sex-matched Japanese general population (GP) data. At a median follow-up of 3.4 years, 985 patients experienced an event and 657 patients died. Patients who achieved an event-free survival (EFS) at 36 months (EFS36) had an OS equivalent to that of the matched GP (standard mortality ratio [SMR], 1.17; P=0.1324), whereas those who achieved an EFS24 did not have an OS comparable to that of the matched GP (SMR, 1.26; P=0.0095). Subgroup analysis revealed that relatively old patients (>60 years), male patients, those with limited-stage disease, those with a good performance status, and those with low levels of soluble interleukin 2 receptor already had a comparable life expectancy to the matched GP at an EFS24. In contrast, relatively young patients had a shorter life expectancy than matched GP, even with an EFS36. In conclusion, an EFS36 was shown to be a more suitable endpoint for newly diagnosed DLBCL patients than an EFS24. Of note, younger patients require a longer EFS period than older patients in order to obtain an equivalent life expectancy to the matched GP. - Longitudinal mortality risks and kidney functional outcomes in Japanese living kidney donors.
Takayuki Hirose; Kiyohiko Hotta; Takahiro Osawa; Isao Yokota; Tasuku Inao; Tatsu Tanabe; Naoya Iwahara; Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 2024年01月19日, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: Previous studies suggested that living kidney donors do not have a higher risk of death or kidney failure than the general population. However, living kidney donor risk is controversial. Furthermore, only a few studies have evaluated long-term kidney function after kidney donation. METHODS: This study evaluated Japanese kidney donor' long-term outcomes, including mortality and kidney function. From 1965 to 2015, 230 donors (76 males, 154 females, and a median age of 54) were enrolled in this study. The median observation period was 11.0 (range, 0.3-41.0) years. RESULTS: In total, 215 donors were still alive, and 15 had died. Causes of death included malignancies, cardiovascular disease, pneumonia, suicide, gastrointestinal bleeding, and kidney failure. Actual donor survival rates at 10, 20, and 30 years were 95.3%, 90.7%, and 80.9%, respectively. These values were comparable to age- and gender-matched expected survival. Long-term kidney function after donation was evaluated in 211 donors with serum creatinine data. Two donors developed kidney failure 24 and 26 years post-donation, respectively. The percentage of donors whose estimated glomerular filtration rate (eGFR) remained ≥45 mL/min/1.73 m2 at 10, 20, and 30 years after donation were 84.2%, 73.0%, and 63.9%, respectively. Survival rates of donors with eGFR <45 mL/min/1.73 m2 were comparable to those in persons with eGFR >45 mL/min/1.73 m2 . CONCLUSION: Our findings revealed that kidney donors did not have a higher long-term risk of death than the general population. Although some donors showed decreased kidney function after donation, kidney function did not impact their survival. - Evaluation of the Loopamp SARS-CoV-2 detection kit using saliva for the detection of SARS-CoV-2 Omicron
Oguri Satoshi; Iwasaki Sumio; Inao Tasuku; Yokota Isao; Murakami Kaoru; Tanaka Kumiko; Hayasaka Kasumi; Fujisawa Shinichi; Watanabe Chiaki; Konno Satoshi; Murakami Masaaki; Teshima Takanori
Laboratory Medicine International, 3, 3, 70, 73, Japanese Society of Laboratory Medicine, 2024年
英語, Aims: The Omicron variant of SARS-CoV-2 spreads more rapidly than ancestral lineages. Reverse-transcription loop-mediated isothermal amplification (RT-LAMP) provides results more rapidly than reverse-transcription
polymerase chain reaction (RT-PCR). However, the reliability in detecting omicrons variant is still unclear due
to possible differences in target sequences.
Methods: Fifty-one saliva specimens, which were positive for the Omicron variant SARS-CoV-2 by real-time RT-PCR and sequencing of the S region, were subjects for this study. The RT-LAMP assay was performed using
the Loopamp SARS-CoV-2 detection kit with (n=51) or without it (n=50).
Results: The RT-LAMP assay following RNA extraction from saliva specimens had a sensitivity of 100% (95%CI: 93.0–100.0%) with 0.969 Kendall’s coefficient of concordance between LAMP threshold time and PCR cycle
threshold value. Forty-five of fifty (90.0%, 95%CI: 78.2–96.7%) specimens positive were also positive by RTLAMP
without RNA extraction.
Conclusions: The Omicron variant was effectively detected in saliva by RT-LAMP using saliva specimens and RNA extraction could improve its efficacy. - Simulation studies on the estimation of sensitivity and specificity in the absence of a gold standard and with rare positive frequencies
Tasuku Inao; Kazufumi Okada; Yichi Yang; Isao Yokota
COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION, 2023年03月
英語, 研究論文（学術雑誌） - Potential determinants of T helper 2 markers and their distribution in school-aged children.
Houman Goudarzi; Atsuko Ikeda-Araki; Yu Ait Bamai; Sachiko Ito; Tasuku Inao; Isao Yokota; Chihiro Miyashita; Reiko Kishi; Satoshi Konno
Allergology international : official journal of the Japanese Society of Allergology, 72, 1, 100, 106, 2022年08月30日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: There is growing data on T helper 2 (Th2) biomarker determinants in adult populations. However, the determinants and typical range of these biomarkers have not been well studied in general populations of children. Therefore, we assessed the determinants and typical range of three Th2 biomarkers, including blood eosinophils, FeNO, and serum total IgE in 9-11-year-old children in a prospective birth cohort. METHODS: We examined the pre- and postnatal factors associated with Th2 biomarkers using multivariable logistic regression analysis (n = 428) and extended the results to the original cohort (n = 17,009) using inverse probability weighting. We also measured typical Th2 biomarker distribution in all examined children and healthy participants without allergic diseases (n = 180). RESULTS: At age 9-11, wheeze (odds ratio (OR) 7.63), rhinitis (OR 3.14), and eczema (OR 2.46) were significantly associated with increased blood eosinophils. All three allergic conditions were associated with FeNO and total serum IgE, but the ORs were smaller than those for blood eosinophils. Secondhand smoking was inversely associated with the blood eosinophils (OR, 0.38). Similar results were found in the original cohort. Male sex and prenatal factors (maternal smoking and parental history of allergies) were not independent predictors of high Th2 levels. CONCLUSIONS: In addition to wheezing and rhinitis, eczema and secondhand smoke exposure are independent factors for Th2 biomarker interpretation in children. Furthermore, the typical values and cutoff values of blood eosinophils in adults may not be applicable to children. - Mass Screening of Asymptomatic Persons for Severe Acute Respiratory Syndrome Coronavirus 2 Using Saliva.
Isao Yokota; Peter Y Shane; Kazufumi Okada; Yoko Unoki; Yichi Yang; Tasuku Inao; Kentaro Sakamaki; Sumio Iwasaki; Kasumi Hayasaka; Junichi Sugita; Mutsumi Nishida; Shinichi Fujisawa; Takanori Teshima
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73, 3, e559-e565, 2021年08月02日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Coronavirus disease 2019 (COVID-19) has rapidly evolved to become a global pandemic, largely owing to the transmission of its causative virus through asymptomatic carriers. Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic people is an urgent priority for the prevention and containment of disease outbreaks in communities. However, few data are available in asymptomatic persons regarding the accuracy of polymerase chain reaction testing. In addition, although self-collected saliva samples have significant logistical advantages in mass screening, their utility as an alternative specimen in asymptomatic persons is yet to be determined. METHODS: We conducted a mass screening study to compare the utility of nucleic acid amplification, such as reverse-transcription polymerase chain reaction testing, using nasopharyngeal swab (NPS) and saliva samples from each individual in 2 cohorts of asymptomatic persons: the contact-tracing cohort and the airport quarantine cohort. RESULTS: In this mass screening study including 1924 individuals, the sensitivities of nucleic acid amplification testing with NPS and saliva specimens were 86% (90% credible interval, 77%-93%) and 92% (83%-97%), respectively, with specificities >99.9%. The true concordance probability between the NPS and saliva tests was estimated at 0.998 (90% credible interval, .996-.999) given the recent airport prevalence of 0.3%. In individuals testing positive, viral load was highly correlated between NPS and saliva specimens. CONCLUSION: Both NPS and saliva specimens had high sensitivity and specificity. Self-collected saliva specimens are valuable for detecting SARS-CoV-2 in mass screening of asymptomatic persons.
- 当科のサルコイドーシス組織診断症例における悪性腫瘍発症に関する研究
中村 友彦; 佐藤 隆博; 稲尾 翼; 小森 卓; 吉川 修平; 中村 順一; 辻野 一三; 横田 勲; 今野 哲, 日本サルコイドーシス/肉芽腫性疾患学会雑誌, 45, サプリメント号, 69, 69, 2025年10月
日本サルコイドーシス, 日本語 - 生体腎移植ドナーの長期生命予後と腎機能推移の検討
広瀬 貴行; 堀田 記世彦; 大澤 崇宏; 横田 勲; 稲尾 翼; 田邉 起; 岩原 直也; 篠原 信雄, 泌尿器外科, 38, 9, 993, 994, 2025年09月
医学図書出版(株), 日本語 - 人口動態を用いた必要産婦人科医指数の推定
吉増 崇志; 稲尾 翼; 横田 勲, 日本周産期・新生児医学会雑誌, 60, Suppl.1, P241, P241, 2024年06月
(一社)日本周産期・新生児医学会, 日本語 - DLBCLにおける適切なエンドポイントはEFS36である
泉山 康; 稲尾 翼; 後藤 秀樹; 原田 晋平; 千丈 創; 須藤 啓斗; 橋口 淳一; 小笠原 励起; 佐賀 智之; 五十嵐 哲祥; 若狭 健太郎; 笠原 郁美; 武田 紫; 山口 圭介; 重松 明男; 高畑 むつみ; 藤本 勝也; 長谷山 美仁; 永嶋 貴博; 酒井 基; 柿木 康孝; 黒澤 光俊; 横田 勲; 豊嶋 崇徳, 日本血液学会学術集会, 85回, 916, 916, 2023年10月
(一社)日本血液学会, 英語 - Exact sequential single-arm trial design with curtailment for binary endpoint
Tasuku Inao; Isao Yokota, 2023年03月30日
Due to ethical and economical reasons, sequential single-arm trial designs
are used for assessing the therapeutic efficacy of new treatments in phase II
trials. Simon's 2-stage design and Lan-DeMets' $\alpha$-spending function
method with O'Brien-Fleming type are widely recognized as the traditional
methods for futility stopping and efficacy stopping, respectively. These
methods have two practical problems, which are the difficulty of interpretation
for stopping under staggered entry and the inflation of error rate due to a
small-sample trial. In this research, we propose the exact sequential design
making the threshold value for efficacy fixed, and compare with traditional
designs in sample size. Since the maximum sample size and average sample number
of the proposed design are generally smaller than those of traditional designs
containing fixed design, the proposed design is expected to be enrolled fewer
subjects. In addition, we evaluate several kinds of point estimators and
confidence intervals at the end of trials in the proposed design. If one is
concerned with bias, the bias-adjusted estimator may be better. As for a
confidence interval, the mid-p approach will be a good choice. - 二値エンドポイントに対する早期中止を行う正確な単群逐次試験デザインの提案
稲尾翼; 横田勲, 日本計量生物学会年会講演予稿集, 2022, 2022年 - 生体腎移植ドナーの長期生命予後と腎機能推移の検討
堀田 記世彦; 大澤 崇宏; 横田 勲; 稲尾 翼; 田邉 起; 岩原 直也; 篠原 信雄, 日本泌尿器科学会総会, 109回, 総会臨時, OP56, 07, 2021年12月
(一社)日本泌尿器科学会総会事務局, 日本語 - 生体腎移植ドナーの腎機能と透析導入リスク 生体腎移植ドナーの長期生命予後と腎機能推移の検討
堀田 記世彦; 大澤 崇宏; 横田 勲; 稲尾 翼; 田邉 起; 岩原 直也; 篠原 信雄, 移植, 56, 総会臨時, SSY2, 4, 2021年09月
(一社)日本移植学会, 日本語
- Exact sequential single-arm trial design with curtailment for binary endpoint
Tasuku Inao; Isao Yokota
ENAR 2023 Spring Meeting, 2023年03月19日, 英語, ポスター発表
2023年03月19日 - 2023年03月22日 - 二値エンドポイントに対する早期中止を行う正確な単群逐次試験デザインの提案
稲尾 翼; 横田 勲
2022年度 計量生物学会年会, 2022年05月14日, 日本語, 口頭発表（一般）
2022年05月13日 - 2022年05月14日 - 二値アウトカムにおける逐次検定手法の性能比較
稲尾 翼; 横田 勲
2021年度 日本分類学会シンポジウム, 2021年12月12日, 日本語, 口頭発表（一般）
2021年12月11日 - 2021年12月12日 - 陽性の頻度が稀な診断結果データに対するgold standardな検査法がない場合の感度・特異度推定
稲尾 翼; 岡田 和史; 楊 一馳; 横田 勲
日本分類学会 第39回大会, 2020年11月08日, 日本語, 口頭発表（一般）
2020年11月07日 - 2020年11月08日 - 陽性の頻度が稀な診断結果データに対するgold standard がない場合の感度・特異度推定
稲尾 翼; 岡田 和史; 楊 一馳; 横田 勲
第15回 Biostatistics Network, 2020年09月05日, 日本語, 公開講演，セミナー，チュートリアル，講習，講義等
2020年09月05日 - 2020年09月05日
