研究活動情報

• Preoperative humeral computed tomography may be a useful indicator of low bone mineral density in patients undergoing rotator cuff repair.
  Yuki Matsui; Yusuke Menjo; Yoshihiro Hojo; Daisuke Momma; Norimasa Iwasaki
  JSES reviews, reports, and techniques, 6, 2, 100624, 100624, 2026年05月, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Bone fragility can compromise rotator cuff repair, particularly in patients with osteoporosis. Although previous studies have demonstrated correlations between systemic bone mineral density (BMD) and bone quality, only a few have focused on the anchor-relevant regions in patients with rotator cuff tears. We hypothesized that preoperative computed tomography (CT)-based Hounsfield unit (HU) values at anchor-relevant areas in the proximal humerus could be used to estimate systemic BMD in these patients. METHODS: This retrospective study included 58 patients (62 shoulders) who underwent arthroscopic rotator cuff repair and had both preoperative shoulder CT and dual energy X-ray absorptiometry scans. HU values were measured in 4 regions of interest within the proximal humerus: medial, central, lateral, and greater tuberosity (GT). Systemic BMD was assessed using femoral neck and lumbar spine T-scores and BMD values. Pearson correlation coefficients were used to evaluate the association between the HU values and systemic T-score/BMD. Multivariate linear regression analyses were performed using HU values at the GT after adjusting for age, sex, and rotator cuff tear size. RESULTS: HU values were significantly lower in the lateral and GT regions than in the medial and central regions (P < .01). Among regions, the HU values at the GT showed the highest correlations with the systemic T-scores and BMD (all moderate): femoral neck T-score (r = 0.57), lumbar spine T-score (r = 0.55), femoral neck BMD (r = 0.60), and lumbar spine BMD (r = 0.56) (all P < .01). Multivariate regression confirmed that GT values were independently associated with both femoral and lumbar T-score/BMD (adjusted R2 = 0.37-0.45, P < .001), even after controlling age, sex, and tear size. CONCLUSION: Preoperative CT-derived HU values, particularly at the GT, have a moderate correlation with systemic T-scores and BMD in patients with rotator cuff tears. Given the lower HU values observed at the anchor insertion sites (GT and lateral regions), clinicians should consider the risk of bone fragility during surgical planning.
• Stage-Based Surgical Strategies and Outcomes for Preiser Disease: A Single-Center Experience.
  Hiroaki Kida; Yuichiro Matsui; Akio Minami; Daisuke Kawamura; Takeshi Endo; Daisuke Momma; Tsutomu Endo; Hirofumi Miyaji; Norimasa Iwasaki
  Hand (New York, N.Y.), 15589447251391379, 15589447251391379, 2025年12月01日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The optimal surgical approach for Preiser disease, a rare avascular necrosis of the scaphoid, remains unclear. Our institution employs a stage-based strategy: vascularized bone grafting (VBG) or closing radial wedge osteotomy (CRWO) for early disease (Herbert classification stages 1-2) and proximal row carpectomy (PRC) for advanced disease (stages 3-4). This study evaluates this stage-based surgical approach. METHODS: We retrospectively analyzed 8 patients (mean age: 60.6 years) who underwent surgical treatment for Preiser disease between 2000 and 2019. Preoperative evaluation included Herbert and Kalainov classifications. Outcome measures included the range of motion (ROM), grip strength (GS), pain (numeric rating scale [NRS] score), Modified Mayo Wrist Score (MMWS), and radiological parameters. Mean follow-up was 50 months. RESULTS: Five patients had stage 2, 1 had stage 3, and 2 had stage 4 disease. Seven patients were treated according to our strategy; 1 stage 4 patient deviated. In those treated per protocol, the VBG/CRWO group (n = 5) and the PRC group (n = 2) showed improvements across all clinical outcomes. Despite clinical gains, radiographic disease progression occurred in 4 of the 5 patients in the VBG/CRWO group. The patient treated outside the standard approach experienced clinical deterioration and developed dorsal intercalated segment instability deformity. CONCLUSION: Our stage-based surgical strategy for Preiser disease yields favorable clinical outcomes. While radiographic progression may occur regardless of treatment, clinical improvements are generally maintained when procedures are appropriately selected based on disease stage.
• バイオマテリアル研究の実用化へ向けて アルギン酸ゲルを用いた軟骨再生医療の最前線 低侵襲化と臨床応用
  小野寺 智洋; 岩崎 浩司; 松岡 正剛; 近藤 英司; 門間 太輔; 岩崎 倫政
  日本整形外科学会雑誌, 99, 8, S1601, S1601, (公社)日本整形外科学会, 2025年09月
  日本語
• PSI and navigation system improve consistency of baseplate placement in reverse shoulder arthroplasty regardless of surgical experience.
  Hiroaki Kida; Daisuke Momma; Atsushi Urita; Yuki Matsui; Tomoaki Suzuki; Akihito Sotome; Tomoyo Irie; Hidemasa Terao; Kyosuke Numaguchi; Eiji Kondo; Yuichiro Matsui; Norimasa Iwasaki
  Journal of shoulder and elbow surgery, 2025年08月07日, ［査読有り］, ［責任著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The success of reverse shoulder arthroplasty (rTSA) relies on accurate glenoid baseplate positioning. Patient-specific instrumentation (PSI) and navigation systems are computer-assisted technologies introduced to improve positioning accuracy; however, no direct comparison of these technologies has been conducted in the same clinical setting. This study aimed to compare baseplate positioning accuracy of conventional technique, PSI, and navigation systems and to investigate whether these computer-assisted technologies enable consistent placement regardless of the surgeon's experience. METHODS: This retrospective study analyzed 110 shoulders of 108 patients who underwent rTSA between November 2017 and April 2024. Patients were divided into Conventional (n = 36), PSI (n = 24), and Navigation (n = 50) groups. Procedures were performed by eight surgeons classified as novice (<10 rTSA cases) or experienced (≥20 rTSA cases). Postoperative CT was used to evaluate baseplate alignment based on version and inclination. Positioning accuracy was compared among groups and between experience levels. RESULTS: Mean version and inclination showed no significant differences among the groups (P = .552 and P = .051, respectively). Precision in version was significantly higher in the PSI and Navigation groups than in the Conventional group (PSI: P = .014, Navigation: P < .001). Precision in inclination was also higher in these two groups (both P < .001). In the Conventional group, novice surgeons showed significantly lower precision in inclination than experienced surgeons (P = .042), whereas the PSI and Navigation groups showed no significant differences between experience levels. The Navigation group achieved significantly longer screw lengths in multiple positions than the Conventional group, and augmented baseplate use was significantly higher in the PSI group. CONCLUSION: Both PSI and navigation systems provide better precision in baseplate positioning than conventional techniques and help eliminate the experience gap between novice and experienced surgeons. These computer-assisted technologies may help standardize surgical outcomes across different levels of surgical experience in rTSA.
• 再生医療 モチジェル(高純度硬化性ゲル)の再生医療応用と製品化の進展
  小野寺 智洋; 岩崎 浩司; 松岡 正剛; 江畑 拓; 佐藤 大; 原 健人; 近藤 英司; 門間 太輔; 鈴木 孝治; 井上 雅之; 岩崎 倫政
  東日本整形災害外科学会雑誌, 37, 3, 177, 177, 東日本整形災害外科学会, 2025年08月
  日本語
• 手関節外科の20年後を見据えて 関節リウマチおよび変形性関節症に対する全人工関節手根骨ステムの至適エントリーポイントの検討
  遠藤 健; 河村 太介; 木田 博朗; 寺尾 英将; 入江 朋世; 松井 雄一郎; 門間 太輔; 岩崎 倫政
  日本関節病学会誌, 44, 2, 169, 169, (一社)日本関節病学会, 2025年06月
  日本語
• Long-Term Outcomes of Radial Shortening Osteotomy for Kienböck Disease: Minimum 20-Year Follow-Up Study.
  Tomoaki Suzuki; Yuichiro Matsui; Daisuke Momma; Takeshi Endo; Hirofumi Miyaji; Norimasa Iwasaki
  The Journal of hand surgery, 2025年05月27日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, PURPOSE: We have been performing radial shortening osteotomies for patients with negative ulnar variance and Lichtman stage 2 or higher Kienböck disease. Although we previously reported the results of this procedure 10 years after surgery, reports on follow-up beyond 10 years remain scarce. This study aimed to investigate the results of radial shortening osteotomy for Kienböck disease based on long-term clinical and radiographic outcomes for a minimum of 20 years after surgery. METHODS: The cohort comprised seven patients with eight wrists treated between 1991 and 2002, whose average age at the time of surgery was 25.9 years (range: 17-44 years). The preoperative Lichtman classification was stage 3A in one wrist, 3B in five, and stage 4 in one; the mean preoperative ulnar variance was -2.2 mm (range: -1.0 to -3.5 mm). Changes in pain, range of motion, grip strength, modified Mayo Wrist Score, Disabilities of the Arm, Shoulder, and Hand (DASH) score, and radiographs were evaluated from 10 years after surgery to the last follow-up at least 20 years after surgery. RESULTS: Pain remained reduced in all patients at 20 years after surgery. Improvements in wrist extension and flexion observed 10 years after surgery were maintained at the last follow-up. Grip strength at 10 years after surgery was maintained at the last follow-up. The mean modified Mayo wrist score and the mean DASH score were maintained from 10 years after surgery to the last follow-up. Radiography showed no progression of lunate collapse in any case, although one case showed progression of degeneration in the radiocarpal joint and the distal radioulnar joint. CONCLUSIONS: Good clinical results observed in patients 10 years after radial shortening osteotomy are likely to remain stable at 20 years after surgery. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic V.
• A 10-year follow-up of autogenous osteochondral transplantation combined with medial opening-wedge high tibial osteotomy for large medial femoral condyle chondral delamination: A case report.
  Takuma Kaibara; Eiji Kondo; Akihito Sotome; Takaaki Fukui; Masatake Matsuoka; Koji Iwasaki; Tomohiro Onodera; Daisuke Momma; Norimasa Iwasaki
  Joint diseases and related surgery, 36, 2, 444, 455, 2025年04月05日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, Chondral delamination, characterized by separation between the articular cartilage and subchondral bone, commonly affects middle-aged adults and can evolve into cartilage defects. Management of extensive chondral delamination presents a significant challenge, particularly in preserving the delaminated yet structurally intact cartilage. Despite its clinical importance, there is no standardized treatment protocol for this condition, and there are few long-term follow-up studies of its surgical management. This case report presents the long-term clinical and radiological outcomes of a novel combined surgical approach for large chondral delamination in a neutrally aligned knee, and discuss the benefits and potential complications of this treatment strategy. In conclusion, autogenous osteochondral transplantation combined with medial opening-wedge high tibial osteotomy shows excellent long-term functional outcomes for large medial femoral condyle chondral delamination.
• Double-bundle posterior cruciate ligament reconstruction procedure leads to better restoration of posterior knee laxity in isolated and multiple ligament knee injuries than single-bundle procedure.
  Eiji Kondo; Yoshio Nishida; Zenta Joutoku; Daisuke Kawamura; Koji Iwasaki; Masatake Matsuoka; Tomohiro Onodera; Daisuke Momma; Tomonori Yagi; Norimasa Iwasaki; Kazunori Yasuda
  Journal of experimental orthopaedics, 12, 2, e70295, 2025年04月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, PURPOSE: The purpose of the study was to determine whether the knee stability is better with single-bundle (SB) or double-bundle (DB) posterior cruciate ligament (PCL) reconstruction. The hypothesis was that DB PCL reconstruction in isolated and multiple ligament knee injuries may be significantly better in the posterior laxity than SB procedure. METHODS: A retrospective study was conducted with 51 patients who underwent PCL reconstruction. Seventeen cases required isolated PCL reconstruction, and the others had the following additional ligament reconstruction; 25 cases required anterior cruciate ligament reconstruction, 11 cases required posteromedial corner reconstruction, and eight cases required posterolateral corner reconstruction. All patients were divided into two groups: In Group S, 20 patients underwent SB PCL reconstruction. In Group D, 31 patients underwent DB PCL reconstruction. Clinical outcomes were evaluated at 2 years or more after surgery. The paired Student t-test, Mann-Whitney U-test and chi-square test were used to test for significance. RESULTS: The postoperative anterior-posterior (AP) translation at 20° and 70° and the relative femur-tibia position in the anterior and posterior stress radiographs at 90° significantly improved postoperatively in both groups. The postoperative side-to-side differences in AP translation at 20° and 70° showed no significant difference between the groups. The relative femur-tibia position in the posterior stress radiographs at 90° was significantly less (p < 0.0001) in Group D (mean, SD, 95% confidence interval; 54.0%, 5.2%, 52.1%-55.8%) than in Group S (43.8%, 5.7%, 41.3%-46.3%). There were no significant differences in the valgus and varus laxities, Lysholm score, International Knee Documentation Committee (IKDC) evaluation, Knee Injury and Osteoarthritis Outcome Score (KOOS), Tegner scale, and complications between the two procedures. CONCLUSIONS: There were no significant differences in the Lysholm score, IKDC evaluation, and KOOS, Tegner scale between both groups although there was significantly better posterior stability in 90° flexion with DB reconstruction. LEVEL OF EVIDENCE: Level III.
• 膝関節再生医療の現状と課題 バイオマテリアルを用いた軟骨再生治療の低侵襲化の試みと未来への展望
  小野寺 智洋; 岩崎 浩司; 松岡 正剛; 江畑 拓; 佐藤 大; 細川 吉暁; 近藤 英司; 門間 太輔; 鈴木 孝治; 井上 雅之; 岩崎 倫政
  日本整形外科学会雑誌, 99, 2, S377, S377, (公社)日本整形外科学会, 2025年03月
  日本語
• Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation.
  Takuma Kaibara; Eiji Kondo; Masatake Matsuoka; Koji Iwasaki; Tomohiro Onodera; Daisuke Momma; Zen-Ichi Tanei; Shinya Tanaka; Norimasa Iwasaki
  BMC musculoskeletal disorders, 26, 1, 115, 115, 2025年02月04日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Subchondral bone cysts (SBCs) can significantly impact the outcomes of cartilage repair procedures such as autologous chondrocyte implantation (ACI). However, the etiology and progression of SBCs following ACI remain poorly understood. This case report highlights a progressively enlarging SBC following ACI using all-suture anchors, treated with autologous osteochondral transplantation (AOT). CASE PRESENTATION: A 58-year-old female with progressive right knee pain, varus alignment, and Kellgren-Lawrence grade 3 osteoarthritis underwent atelocollagen-associated ACI combined with medial opening wedge high tibial osteotomy. Longitudinal radiological assessment revealed bone hole enlargement corresponding to all-suture anchor sites, with one hole continuing to expand up to 15 months postoperatively, reaching a size of 11 × 13 × 13 mm. This expanding SBC exhibited a connection to the joint cavity via a tiny fissure, scant osteosclerotic rim on CT, and fluid intensity on MRI. Histological analysis of tissue obtained during subsequent AOT revealed several findings. The SBC was located at the anterior portion of the medial femoral condyle, just beneath the all-suture anchor. Osteochondral necrosis was observed surrounding the anchor site, with no evidence of foreign body reaction. The cyst was filled with a mucoid substance and featured an aggregation of foamy macrophages. A sclerotic wall indicative of a strain response was observed. Notably, the presence of osteoclasts along the adjacent bone surface indicated ongoing bone resorption. The patient underwent AOT, which resulted in confirmed bone union. Postoperative follow-up demonstrated successful integration of the osteochondral graft and improved knee function scores over three years. CONCLUSION: This case report documents SBC formation following knee surgery with all-suture anchors and provides histological evaluation of such a cyst. The observed histological findings may contribute to our understanding of SBC pathophysiology in the context of cartilage repair procedures. This case underscores the importance of secure suturing techniques in high-stress areas and suggests the potential benefit of extended post-operative monitoring of SBC progression beyond one year. These observations may inform future strategies for the early detection of SBC formation and its progression, as well as timely intervention to prevent further joint damage in similar cases, though further research is needed to establish broader clinical implications.
• 高純度アルギン酸ゲルを用いた肘離断性骨軟骨炎に対する治療
  門間 太輔; 沼口 京介; 近藤 英司; 小野寺 智洋; 岩崎 倫政
  日本肘関節学会雑誌, 32, 1, S74, S74, 日本肘関節学会, 2025年
  日本語
• Stress Distribution Patterns of the Femorotibial Joint After Medial Closing-Wedge Distal Femoral Varus Osteotomy: An Evaluation Using Computed Tomography Osteoabsorptiometry.
  Masanari Hamasaki; Eiji Kondo; Koji Iwasaki; Yuki Suzuki; Masatake Matsuoka; Tomohiro Onodera; Koji Yabuuchi; Daisuke Momma; Masayuki Inoue; Kazunori Yasuda; Tomonori Yagi; Norimasa Iwasaki
  The American journal of sports medicine, 52, 13, 3255, 3265, 2024年11月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Distal femoral varus osteotomy (DFVO) is an established surgical procedure for addressing valgus malalignment across various knee conditions. However, the effect of DFVO on stress distribution within the femorotibial joint has not been explored through in vivo studies. PURPOSE: To (1) explore the distribution pattern of subchondral bone density across the proximal tibia in nonarthritic knees without arthritis and in those of patients with valgus knees, (2) assess changes in the pattern of bone density distribution in patients with valgus knees before and after medial closing-wedge (MCW) DFVO, and (3) determine the correlation between leg alignment and changes in bone density distribution. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: The authors retrospectively analyzed clinical and radiographic data from 14 patients (14 knees; mean age, 44 years; 3 men, 11 women) treated with MCW-DFVO for lateral compartment osteoarthritis (OA) due to valgus malalignment, alongside a control group of 18 patients (18 knees; mean age, 21 years; 4 men, 14 women) without OA. The distribution patterns of subchondral bone density distribution on the femorotibial articular surface of the tibia were examined both preoperatively and >1 year postoperatively using computed tomography osteoabsorptiometry. Quantitative analyses were conducted on the locations and percentages of the high-density areas (HDAs) on the articular surface. The mean time between surgery and the postoperative radiograph and computed tomography absorptiometry imaging was 13.6 months (range, 11-19 months). The mean length of clinical follow-up was 28.7 months (range, 14-62 months) after surgery. RESULTS: The mean proportion of HDA in the lateral compartment relative to the total HDA (lateral ratio) was significantly greater in the preoperative OA group (58.8%) compared with the control group (41.1%) (P < .001). After MCW-DFVO, the mean lateral ratio in the OA group notably declined to 45.3% (P < .001). The lateral ratio exhibited a significant correlation with the hip-knee-ankle angle in both the control (r = 0.630; P = .011) and OA (r = 0.537; P = .047) groups. Moreover, the alteration in the lateral ratio after MCW-DFVO showed a significant relationship with changes in the hip-knee-ankle angle (r = 0.742; P = .002) and the mechanical lateral distal femoral angle (r = -0.752; P = .002). Within the lateral compartment, HDAs in the 3 lateral regions of the 4 lateral subregions diminished after MCW-DFVO, whereas in the medial compartment, HDAs in the 3 lateral subregions saw an increase. CONCLUSION: The mean lateral ratio was significantly greater in the preoperative OA group compared with the control group. MCW-DFVO resulted in a redistribution of HDA from the lateral to the medial compartment of the proximal tibial articular surface. The extent of alignment correction after MCW-DFVO was closely linked to the shifts in HDA distribution, reflecting changes in stress distribution.
• Natural Recovery of Very Limited Elbow Flexion After Rare Lateral Humeral Condylar Fracture in a 4-Year-Old Boy: A Case Report.
  Koki Ohta; Yuichiro Matsui; Hiroyuki Kato; Daisuke Kawamura; Takeshi Endo; Daisuke Momma; Tamotsu Kamishima; Tatsunori Horie; Hirofumi Miyaji; Norimasa Iwasaki
  JBJS case connector, 14, 4, 2024年10月01日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, CASE: A 4-year-old boy developed malunion after open reduction and internal fixation (ORIF) of a rare lateral condylar humeral fracture running from the lateral humerus, through the trochlear cartilage, to the medial trochlea. Five months after ORIF, the active elbow flexion was limited to 50°. Magnetic resonance imaging (MRI) showed a step-off of the anterior trochlear cartilage, causing the limited flexion. After conservative observation for 5 years, the flexion improved to 135° and MRI showed that the step-off had disappeared. CONCLUSION: This case indicates that it is possible for pediatric patients to recover their range of motion following malunion of an elbow fracture.
• Effect of the Sauvé-Kapandji method on the wrist contact surface for distal radial ulnar joint disorders.
  Tomoaki Suzuki; Daisuke Momma; Nozomu Inoue; Eiji Kondo; Yuichiro Matsui; Norimasa Iwasaki
  BMC musculoskeletal disorders, 25, 1, 532, 532, 2024年07月11日, ［査読有り］, ［責任著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The Sauvé-Kapandji (S-K) method is a surgical procedure performed for chronic deformities of the distal radial ulnar joint (DRUJ). Changes to the joint contact surface from pre- to postoperatively under physiological in vivo conditions have not yet been determined for this useful treatment. The aim of the present study was therefore to compare the articular contact area of the wrist joint between before and after the S-K method for DRUJ disorders. METHODS: The SK method was performed for 15 patients with DRUJ osteoarthritis and ulnar impaction syndrome. We calculated the Mayo Wrist Score as the patient's clinical findings and created 3-dimensional bone models of cases in which the S-K method was performed and calculated the contact area and shift in the center of the contact area using customized software. RESULTS: The Mean modified Mayo Wrist Score improved significantly from 60.3 preoperatively to 80.3 postoperatively (P < 0.01). Scaphoid contact area to the radius increased significantly from 112.6 ± 37.0 mm2 preoperatively to 127.5 ± 27.8 mm2 postoperatively (P = 0.03). Lunate contact area to radius-ulna was 121.3 ± 43.3 mm2 preoperatively and 112.5 ± 37.6 mm2 postoperatively, but this decrease was not significant (P = 0.38). Contact area ratio of scaphoid to lunate increased significantly from 1.01 ± 0.4 preoperatively to 1.20 ± 0.3 postoperatively (P = 0.02). Postoperative translations of the center of the scaphoid and lunate contact areas were decomposed into ulnar and proximal directions. Ulnar and proximal translation distances of the scaphoid contact area were 0.8 ± 1.7 mm and 0.4 ± 0.6 mm, respectively, and those of the lunate contact area were 1.1 ± 1.7 mm and 0.4 ± 1.1 mm, respectively. This study revealed changes in wrist contact area and center of the contact area before and after the S-K method. CONCLUSION: These results may accurately indicate changes in wrist joint contact area from pre- to postoperatively using the S-K method for patients with DRUJ disorder. Evaluation of changes in contact area due to bone surface modeling of the wrist joint using 3DCT images may be useful in considering surgical methods.
• Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis.
  Kentaro Homan; Tomohiro Onodera; Hisatoshi Hanamatsu; Jun-Ichi Furukawa; Daisuke Momma; Masatake Matsuoka; Norimasa Iwasaki
  eLife, 12, 2024年03月11日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, This study aimed to investigate the glycan structural changes that occur before histological degeneration in osteoarthritis (OA) and to determine the mechanism by which these glycan conformational changes affect cartilage degeneration. An OA model was established in rabbits using mannosidase injection, which reduced high-mannose type N-glycans and led to cartilage degeneration. Further analysis of glycome in human OA cartilage identified specific corefucosylated N-glycan expression patterns. Inhibition of N-glycan corefucosylation in mice resulted in unrecoverable cartilage degeneration, while cartilage-specific blocking of corefucosylation led to accelerated development of aging-associated and instability-induced OA models. We conclude that α1,6 fucosyltransferase is required postnatally to prevent preosteoarthritic deterioration of articular cartilage. These findings provide a novel definition of early OA and identify glyco-phenotypes of OA cartilage, which may distinguish individuals at higher risk of progression.
• Simultaneous medial closing wedge distal femoral varus osteotomy and double-bundle anterior cruciate ligament reconstruction in the symptomatic femoral valgus deformity: A case report.
  Masatake Matsuoka; Eiji Kondo; Koji Iwasaki; Tomohiro Onodera; Ryuichi Nakamura; Hiroshi Nakayama; Takenori Akiyama; Daisuke Momma; Norimasa Iwasaki
  Joint diseases and related surgery, 35, 2, 422, 432, 2024年02月13日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, Distal femoral varus osteotomy (DFVO) is a widely recognized surgical procedure used to address valgus malalignment in patients with knee joint disorders. However, it still remains unclear whether anterior cruciate ligament (ACL) reconstruction can be performed in a single procedure along with DFVO. Herein, we present a 73-year-old female patient who developed lateral osteoarthritis of the knee with valgus alignment due to chronic ACL deficiency following a twisting injury during skiing. She was physiologically very active, and strongly demanded to return to sports. We performed a combined procedure involving a medial closing wedge DFVO using an anatomical locking plate, along with double-bundle ACL reconstruction. The postoperative radiograph confirmed successful correction of knee alignment, specifically achieving varus alignment with precise conformance of the anatomical plate to the medial contour of the distal femur following the osteotomy. The patient resumed her previous sports activities without experiencing knee pain. The operated knee demonstrated restored anterior stability, as indicated by negative Lachman test results, and regained full range of motion. Both the Knee Injury and Osteoarthritis Outcome Score and the 2011 Knee Society score demonstrated continuous postoperative improvements over the three-year follow-up period, indicating positive functional outcomes and joint preservation. To the best of our knowledge, this is the first case of medial closing wedge DFVO with anatomic double-bundle ACL reconstruction in the symptomatic femoral valgus deformity with chronic ACL deficiency in the literature.
• Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee: Results at three to seven years.
  Takuma Kaibara; Eiji Kondo; Masatake Matsuoka; Koji Iwasaki; Tomohiro Onodera; Keita Sakamoto; Yoshitaka Oda; Zen-Ichi Tanei; Daisuke Momma; Shinya Tanaka; Norimasa Iwasaki
  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 29, 1, 207, 216, 2024年01月, ［査読有り］, ［国内誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Recently, various types of engineered autologous chondrocyte implantation (ACI) have been developed. Atelocollagen-associated ACI (A-ACI) is the only ACI procedure covered by Japanese Health Insurance since 2013. The indications of the A-ACI are traumatic cartilage defects and osteochondral dissecans (OCD) for knee joints. PURPOSE: To evaluate midterm clinical results after A-ACI for the treatment for full-thickness cartilage defects of the knee. METHODS: Thirteen consecutive patients who underwent A-ACI between 2014 and 2018 had been prospectively enrolled in this study. There were 11 men and 2 women with a mean age of 34 years at the time of surgery. The causes of the cartilage defect were trauma in 10 knees and OCD in 3 knees. The total number of lesions was 15, which were comprised of the medial femoral condyle in 5 knees, the lateral femoral condyle in 5 knees, and the femoral trochlea in 5 knees. The mean size of the lesion was 5.3 cm2. Each knee was clinically and radiologically evaluated preoperatively and postoperatively. RESULTS: The mean Lysholm score improved significantly from 74.0 points to 94.0 points (p = 0.008) and each subscale in Knee injury and Osteoarthritis Outcome Score improved significantly (p < 0.001) at the mean final follow-up period of 51 months (range, 36-84 months). The magnetic resonance observation of cartilage repair tissue 2.0 score at the mean follow-up of 38 months was significantly higher than that at 2 months postoperatively (p = 0.014). According to the International Cartilage Repair Society (ICRS) grading scale, 3 knees were graded as normal, 3 knees as nearly normal, and 1 knee as severely abnormal in second-look arthroscopic evaluation at a mean of 22 months (range, 8-41 months) after A-ACI. CONCLUSION: The present study showed a significant subjective and objective clinical improvement in the A-ACI for large cartilage defects of the knee at a mean follow-up of 51 months (range, 36-84 months).
• Median neuropathy after multiple punctures of the forearm for catheterization: A case report.
  Tomoaki Suzuki; Yuichiro Matsui; Daisuke Momma; Takeshi Endo; Norimasa Iwasaki
  World journal of clinical cases, 11, 25, 5941, 5946, 2023年09月06日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Neuropathy may occur at some sites after catheterization for close examination of cardiac disease. Although the radial artery is considered a relatively uncom-plicated site for catheterization, the radial artery and median nerve are in relatively close proximity, with the risk of median nerve injury depending on the angle of puncture. The purpose of this study was to report the outcomes of surgery performed for conservative therapy-resistant median neuropathy following forearm catheterization. CASE SUMMARY: A 50-year-old woman experienced palsy from the right thumb to the radial side of the ring finger after catheterization from the radial artery of the right forearm. Paresthesia developed at the same site and a positive tinel-like sign was seen for the median nerve area at the high level of the puncture site. Nerve conduction study showed reduced compound muscle action potentials and loss of sensory nerve action potentials. Symptoms did not improve despite pharmacotherapy and the patient gradually developed flexion restrictions of the index and middle fingers. Median nerve injury and associated flexor tendon adhesion was diagnosed, and the patient was referred for surgery at 3 mo after injury. When the same area was opened, no injury to the median nerve epithelium was obvious, but the area of the positive tinel-like sign was highly adherent to surrounding tissue and to the flexor digitorum superficialis of the index and middle fingers. The surgery was terminated with adequate adhesion release. Rehabilitation was initiated postoperatively, improving neurological symptoms and range of motion of the fingers. Six months after surgery, the patient returned to daily activities without discomfort. CONCLUSION: This case provides the appropriate diagnosis and treatment for a suspected peripheral nerve injury.
• Single-step ultra-purified alginate gel implantation in patients with knee chondral defects.
  Tomohiro Onodera; Daisuke Momma; Masatake Matsuoka; Eiji Kondo; Koji Suzuki; Masayuki Inoue; Masaki Higano; Norimasa Iwasaki
  The bone & joint journal, 105-B, 8, 880, 887, 2023年08月01日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, AIMS: Implantation of ultra-purified alginate (UPAL) gel is safe and effective in animal osteochondral defect models. This study aimed to examine the applicability of UPAL gel implantation to acellular therapy in humans with cartilage injury. METHODS: A total of 12 patients (12 knees) with symptomatic, post-traumatic, full-thickness cartilage lesions (1.0 to 4.0 cm2) were included in this study. UPAL gel was implanted into chondral defects after performing bone marrow stimulation technique, and assessed for up to three years postoperatively. The primary outcomes were the feasibility and safety of the procedure. The secondary outcomes were self-assessed clinical scores, arthroscopic scores, tissue biopsies, and MRI-based estimations. RESULTS: No obvious adverse events related to UPAL gel implantation were observed. Self-assessed clinical scores, including pain, symptoms, activities of daily living, sports activity, and quality of life, were improved significantly at three years after surgery. Defect filling was confirmed using second-look arthroscopy at 72 weeks. Significantly improved MRI scores were observed from 12 to 144 weeks postoperatively. Histological examination of biopsy specimens obtained at 72 weeks after implantation revealed an extracellular matrix rich in glycosaminoglycan and type II collagen in the reparative tissue. Histological assessment yielded a mean overall International Cartilage Regeneration & Joint Preservation Society II score of 69.1 points (SD 10.4; 50 to 80). CONCLUSION: This study provides evidence supporting the safety of acellular UPAL gel implantation in facilitating cartilage repair. Despite being a single-arm study, it demonstrated the efficacy of UPAL gel implantation, suggesting it is an easy-to-use, one-step method of cartilage tissue repair circumventing the need to harvest donor cells.
• Bilateral Humeral Retrotorsion Angle Measured Using an Ultrasound-Assisted Technique in Asian Baseball Players.
  Shota Ike; Daisuke Momma; Kyosuke Numaguchi; Yuki Matsui; Masashi Yokota; Jun Oohinata; Eiji Kondo; Norimasa Iwasaki
  Orthopaedic journal of sports medicine, 11, 5, 23259671231166927, 23259671231166927, 2023年05月, ［査読有り］, ［責任著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Repetitive pitching is thought to restrict the physiological derotation process of the humeral head. Some studies have reported that side-to-side differences in the humeral retrotorsion angle (ΔHRA) occur between the ages of 9 and 11 years in baseball players. However, it remains unclear whether the ΔHRA in Asian baseball players depends on pitching skill or competitive level. PURPOSE: To evaluate the ΔHRA in Asian collegiate and professional baseball players and to determine the effects of pitching activity on the physiological derotation process of the humeral head. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: We evaluated 128 shoulders in 64 Asian baseball players who were stratified into 4 groups as follows: 13 professional pitchers; 9 professional fielders; 8 collegiate pitchers; and 34 collegiate fielders. The throwing and nonthrowing side HRA was assessed using an ultrasound-assisted technique, and the ΔHRA was compared among the 4 groups. In addition, Pearson correlation analysis was used to assess the relationship between ΔHRA and glenohumeral range of motion, baseball starting age, and fastball velocity in pitchers. RESULTS: The HRA was significantly greater in the throwing arm than in the nonthrowing arm in each group, with no significant differences among the groups. There was no correlation between ΔHRA and range of motion or fastball velocity. There was a significant negative correlation between baseball starting age and ΔHRA in professional fielders (r = -0.633; P = .036). CONCLUSION: The findings of the present study provide evidence that in Asian baseball players, the HRA was significantly greater in the throwing arm than in the nonthrowing arm. There were no clear associations between HRA and pitching ability or competitive level.
• Symptomatic bilateral complete discoid medial menisci of the knee in a child: A case report.
  Yuki Suzuki; Eiji Kondo; Takuma Kaibara; Masatake Matsuoka; Ryosuke Hishimura; Koji Iwasaki; Tomohiro Onodera; Daisuke Momma; Shinya Tanaka; Norimasa Iwasaki
  Joint diseases and related surgery, 34, 2, 455, 462, 2023年04月26日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, Bilateral complete discoid medial menisci are extremely rare congenital anatomic variants of the knee. Currently, arthroscopic partial meniscectomy with or without peripheral suture repair is performed for symptomatic discoid meniscus. However, most of the outcomes are short-term. In this article, we present a pediatric case of symptomatic bilateral complete discoid medial menisci and highlight the effectiveness of arthroscopic partial meniscectomy with or without peripheral suture on symptomatic complete discoid medial menisci based on 60-month excellent clinical and functional results.
• Deep fibrous histiocytoma of the index finger: a case report.
  Hiroki Shibayama; Yuichiro Matsui; Daisuke Kawamura; Daisuke Momma; Takeshi Endo; Yuki Matsui; Yasutaka Yawaka; Kanako C Hatanaka; Emi Takakuwa; Hirokazu Sugino; Yutaka Hatanaka; Tadashi Hasegawa; Norimasa Iwasaki
  Case reports in plastic surgery & hand surgery, 10, 1, 2207637, 2207637, 2023年, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, Our patient presented with an elastic soft mass of his left index finger. Hematoxylin and eosin staining showed a high cellular density with spindle-shaped cells in a storiform pattern. Immunohistochemical staining was positive for CD68, factor XIIIa and α-smooth muscle actin, and negative for CD34, STAT6, S100 protein, and desmin.
• Implications of navigation system use for glenoid component placement in reverse shoulder arthroplasty.
  Hiroaki Kida; Atsushi Urita; Daisuke Momma; Yuki Matsui; Takeshi Endo; Daisuke Kawamura; Hiroshi Taneichi; Norimasa Iwasaki
  Scientific reports, 12, 1, 21190, 21190, 2022年12月07日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, Recently, three-dimensional (3D) planning, patient-specific instruments, and navigation system have been developed to improve the accuracy of baseplate placement in reverse shoulder arthroplasty (RSA). The purpose of this study was to evaluate baseplate placement using the navigation system. Sixty-four shoulders in 63 patients who underwent RSA for rotator cuff tear arthropathy or irreparable rotator cuff tears were enrolled. Conventional RSA was performed in 31 shoulders and navigated RSA using pre-operative planning software was performed in 33 shoulders. The use of augmented baseplates, the version and inclination of the baseplate, and screw length were compared between conventional RSA and navigated RSA. Augmented baseplates were used more frequently in navigated RSA than in conventional RSA (20 vs 9 shoulders, p = 0.014). Baseplate alignment was 1.0° (SD 5.1) of retroversion and 2.4° (SD 6.8) of superior inclination in conventional RSA and 0.2° (SD 1.9) of anteversion and 0.3° (SD 1.7) of superior inclination in navigated RSA. Compared with conventional RSA, precision of baseplate version and inclination were higher in navigated RSA (both p < 0.001). Superior, inferior, and posteroinferior screws were significantly longer in navigated RSA than in conventional RSA (p = 0.021, 0.001 and < 0.001, respectively). Precision of superior and inferior screw lengths was significantly higher in navigated RSA than in conventional RSA (both p = 0.001). Our results suggest that adoption of pre-operative planning software increased augmented baseplate use to minimize the glenoid reaming. The navigation system allows placement of the baseplate accurately, according to the pre-operative plan. Furthermore, the navigation system enables monitoring of screw length and direction in real time.
• Occurrence Rate of Cyclops Lesion After Anatomic Double-Bundle ACL Reconstruction: Comparison Between Remnant Tissue Preservation and Resection Methods.
  Ryosuke Hishimura; Eiji Kondo; Yuki Suzuki; Masatake Matsuoka; Koji Iwasaki; Tomohiro Onodera; Daisuke Momma; Tomonori Yagi; Kazunori Yasuda; Norimasa Iwasaki
  Orthopaedic journal of sports medicine, 10, 10, 23259671221130688, 23259671221130688, 2022年10月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The occurrence rate of cyclops lesion after anatomic double-bundle anterior cruciate ligament (ACL) reconstruction with remnant tissue preservation remains unclear. HYPOTHESIS: The study hypotheses were as follows: (1) the occurrence rate of cyclops lesion will be comparable between the remnant-preserving and remnant-resecting ACL reconstruction methods, and (2) there will be no significant differences in clinical outcomes between the remnant-preserving and remnant-resecting procedures. METHODS: This retrospective comparative study involved 177 patients who underwent unilateral anatomic double-bundle ACL reconstruction using hamstring tendon autografts from 2014 to 2018 at our hospital. According to the Crain classification of ACL remnant tissue, 98 patients with remnant types I, II, or III underwent the remnant-preserving procedure (group A), and the remaining 79 patients with remnant type IV underwent the remnant-resecting procedure (group B). All patients underwent second-look arthroscopy. Patients were evaluated according to arthroscopic and clinical results at postoperative 15.2 ± 8.4 months (mean ± SD). Statistical comparisons between groups were made using the paired Student t test, chi-square test, and Fisher exact test. STUDY DESIGN: Cohort study; Level of evidence, 3. RESULTS: At second-look arthroscopy, the incidence of cyclops lesions was significantly higher in group B than in group A (29.1% vs 13.3%; P = .0139). Cyclops lesions were divided into 4 locations: femoral side (type 1), midsubstance (type 2), tibial side (type 3), and anterior (type 4) of the ACL graft. The ratio of the tibial-side cyclops lesion (type 3) was significantly higher in group B than in group A (P = .0354). There were no significant differences in the clinical evaluation scores between the procedures. Side-to-side anterior laxity was significantly less in group A than in group B (0.7 vs 1.6 mm; P = .0035). Concerning postoperative laceration and synovium coverage of the grafts, group A was significantly better than group B (P < .0001). CONCLUSION: In this cohort of patients undergoing double-bundle ACL reconstruction, resection of the ACL remnant was associated with a significantly higher rate of cyclops lesion formation when compared with preservation of the remnant.
• Effect of the Inverted V-Shaped Osteotomy on Patellofemoral Joint and Tibial Morphometry as Compared With the Medial Opening Wedge High Tibial Osteotomy.
  Eiji Kondo; Koji Yabuuchi; Zenta Joutoku; Shinji Matsubara; Koji Iwasaki; Masatake Matsuoka; Tomohiro Onodera; Daisuke Momma; Masayuki Inoue; Tomonori Yagi; Norimasa Iwasaki; Kazunori Yasuda
  The American journal of sports medicine, 50, 9, 2439, 2452, 2022年07月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Recent studies have reported that medial opening wedge (OW) high tibial osteotomy (HTO) induces patella baja, resulting in degenerative changes in the patellofemoral joint. We have developed an inverted V-shaped (iV) HTO, which is classified as a neutral wedge osteotomy. HYPOTHESES: The study hypotheses were as follows: (1) patellar height, posterior tibial slope, and tibial length will not change between pre- and postoperative evaluations after iV-HTO; (2) the lateral shift ratio of the patella and the distance between the tibial tubercle and the trochlear groove may be significantly decreased after iV-HTO. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A total of 191 patients (220 knees) who underwent HTO for medial osteoarthritis were enrolled retrospectively in this study: 107 knees underwent OW-HTO and 113 knees underwent iV-HTO. Clinical and radiological evaluations were performed before and at least 3 years after surgery. RESULTS: Postoperatively, the mean Caton-Deschamps ratio was significantly decreased (P < .0001) from 0.95 to 0.79 in the OW group, while there were no significant changes in the iV group. The mean posterior tibial slope was significantly increased (P < .0001) from 8.5° to 10.5° in the OW group, while there were no significant differences in the iV group. Although the entire leg length was significantly increased (P < .0003) in both groups after HTO, there were no significant differences in tibial length between the pre- and postoperative periods in the iV group. Regarding the congruity of the patellofemoral joint, the mean lateral shift ratio did not significantly change in the OW group, whereas it was significantly decreased (P = .0012) from 11.5% to 8.8% in the iV group. The mean tibial tubercle-trochlear groove distance was significantly decreased (P < .0001) from 12.8 to 9.7 mm in the iV group, while it was significantly increased in the OW group (P < .0001). Concerning the clinical outcome, the Japanese Orthopaedic Association (JOA) and Lysholm knee scores at final follow-up (OW vs iV: JOA, 91.2 vs 90.1; Lysholm, 92.5 vs 89.0) were significantly increased (P < .0001) as compared with the preoperative values (OW vs iV: JOA, 68.3 vs 66.8; Lysholm, 67.9 vs 61.0). CONCLUSION: Patellar height, posterior tibial slope, and tibial length did not change after the iV-HTO, while they were significantly changed after the OW-HTO. Although the preoperative degrees of varus knee and patellofemoral osteoarthritis were more severe in the iV group than the OW group, the iV-HTO led to altered patellofemoral joint congruity.
• Minimum 5-Year Outcomes of Dorsal Intercarpal Ligament Capsulodesis With Scapholunate Interosseous Ligament Repair for Subacute and Chronic Static Scapholunate Instability: A Clinical Series of 5 Patients.
  Hiroki Shibayama; Yuichiro Matsui; Daisuke Kawamura; Daisuke Momma; Takeshi Endo; Norimasa Iwasaki
  Journal of hand surgery global online, 4, 3, 162, 165, 2022年05月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, PURPOSE: Treatment of subacute and chronic static scapholunate instability remains challenging. We aimed to determine 5- to 10-year outcomes of dorsal intercarpal ligament capsulodesis with scapholunate interosseous ligament repair for subacute and chronic static scapholunate instability. METHODS: Six patients with subacute and chronic static scapholunate instability underwent dorsal intercarpal ligament capsulodesis with scapholunate interosseous ligament repair between 2011 and 2015, and 5 of them were followed for at least 5 years after surgery. The clinical and radiological results were retrospectively investigated. All patients were male, and the mean age at surgery was 37 years (range, 21-47 years). The mean period from injury to surgery was 26.2 months (range, 2-113 months). The surgical procedure was a modification of a method reported by Szabo et al. RESULTS: The mean postoperative follow-up period was 8.1 years (range, 5.1-9.5 years). Median Disabilities of the Arm, Shoulder, and Hand and Mayo wrist scores improved from 23.3 to 1.7 and from 55 to 80, respectively, from before surgery to the final follow-up. Although the median flexion angle tended to be smaller, the median extension angle tended to be greater than before surgery. The median percent grip strength increased from 72.3% before surgery to 99.2% at the final follow-up. The median scapholunate gap improved from 4.2 mm before surgery to 2.1 mm at the final follow-up. The median scapholunate angle also improved from 95.7° before surgery to 71.3° at the final follow-up. Osteoarthritic changes were observed in 2 of 5 patients at the final follow-up. CONCLUSIONS: The scapholunate gap in all patients was within the normal range after a mean of 8.1 years of follow-up. Dorsal intercarpal ligament capsulodesis with scapholunate interosseous ligament repair is considered a good alternative for subacute and chronic static scapholunate instability based on these 5- to 10-year outcomes. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.
• Diagnostic Utility of Superb Microvascular Imaging and Power Doppler Ultrasonography for Visualizing Enriched Microvascular Flow in Patients With Carpal Tunnel Syndrome
  Takeshi Endo; Yuichiro Matsui; Daisuke Kawamura; Atsushi Urita; Daisuke Momma; Mitsutoshi Ota; Hiroki Shibayama; Takahito Iwai; Mutsumi Nishida; Norimasa Iwasaki
  Frontiers in Neurology, 13, 832569, 832569, Frontiers Media SA, 2022年03月31日, ［国際誌］
  英語, 研究論文（学術雑誌）, Recent studies suggest that blood flow changes in the median nerve may help confirm a diagnosis of carpal tunnel syndrome (CTS). Herein, we examined the utility of superb microvascular imaging (SMI), a new ultrasonographic (US) technique for visualizing microvascular flow, for detecting blood flow differences between CTS patients and healthy controls. We performed a retrospective analysis of 28 hands with suspected CTS. Patients received both nerve conduction and US examinations. Ten healthy volunteers were enrolled as the control group. The nerve compression ratio and the blood flow signal area were quantified using color Doppler US (CDUS), power Doppler US (PDUS), and SMI. Correlation analyses between the blood flow signal area, the compound muscle action potential of the thenar muscle, and the nerve compression ratio were performed. As a result, the mean nerve compression ratio was found to be significantly higher in the CTS group. There were no differences in the blood flow signal area between the groups using CDUS, while PDUS and SMI showed higher blood flow signals in the CTS group. The blood flow signal area measured by SMI had stronger correlations with the compound muscle action potential amplitude and the nerve compression ratio than those for PDUS. The diagnostic utility of SMI was equivalent to PDUS, but superior to conventional CDUS. Nevertheless, the blood flow signal by SMI was more strongly correlated with the electrophysiological severity and compression ratio than for PDUS. Use of SMI in future studies may help clarify the underlying mechanisms of blood flow changes in CTS.
• Changes in wrist joint contact area following radial shortening osteotomy for Kienböck's disease.
  Junki Shiota; Daisuke Momma; Yuichiro Matsui; Nozomu Inoue; Eiji Kondo; Norimasa Iwasaki
  Scientific reports, 12, 1, 4001, 4001, 2022年03月07日, ［査読有り］, ［責任著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, We hypothesized that the contact area of the articular surface of the wrist joint could be evaluated using a custom-designed analytical program. The aim of the study was to compare the articular contact area of the wrist joint before and after radial shortening osteotomy for Kienböck's disease. Nine wrists of 9 patients underwent radial shortening osteotomy for Kienböck's disease. Computed tomography (CT) images of the wrist joint were reconstructed using a 3D reconstruction software package. Radioscaphoid and radiolunate joint contact areas and translation of the joint contact area from preoperative to postoperative were calculated using customized software. The mean Modified Mayo Wrist Score was significantly improved from 50.6 preoperatively to 83.3 at final follow-up (p < .001). Preoperatively, the pain was reported as severe in five wrists and moderate in four wrists, while at final follow-up, five patients were free from pain and four patients had mild pain with vigorous activity. The preoperative radioscaphoid joint contact area was 133.4 ± 49.5 mm2 and the postoperative radioscaphoid joint contact area was 156.4 ± 73.1 mm2. The preoperative radiolunate joint contact area was 194.8 ± 92.1 mm2 and the postoperative radiolunate joint contact area was 148.3 ± 97.9 mm2. The radial translation distance was 0.4 ± 1.2 mm, the dorsal translation distance was 0.6 ± 1.2 mm, and the proximal translation distance was 0.2 ± 0.4 mm. CT-based analysis revealed that the center of the contact area translated radially following radial shortening.
• Double-bundle anterior cruciate ligament reconstruction using autologous hamstring tendon hybrid grafts in a patient with hypermobile Ehlers-Danlos Syndrome: A case report.
  Ryosuke Hishimura; Eiji Kondo; Masatake Matsuoka; Koji Iwasaki; Yasuyuki Kawaguchi; Yuki Suzuki; Tomohiro Onodera; Daisuke Momma; Norimasa Iwasaki
  The Knee, 35, 81, 86, 2022年03月, ［国際誌］
  英語, BACKGROUND: Ehlers-Danlos syndrome (EDS) is a connective tissue disorder characterized by skin hyperextensibility, joint hypermobility, and tissue friability. Hypermobile type Ehlers-Danlos syndrome (hEDS) is considered one of the EDS subtypes characterized by generalized joint hypermobility. Although there have been a few case reports which described surgical considerations for anterior cruciate ligament (ACL) reconstructions in patients with other types of EDS, no reports have described those in patients with hEDS. CASE PRESENTATION: We report a case of ACL injury in an 18-year-old male patient with hEDS. The patient was successfully treated with an anatomic double-bundle ACL reconstruction using autologous hamstring tendon hybrid grafts which consist of hamstring tendons connected in a series with commercially available polyester tape. The autogenous tendon portion of the anteromedial and posterolateral bundles were composed of 4 and 2 strands of hamstring tendons, respectively. After 2 weeks of knee joint immobilization, continuous passive motion exercise of the knee joint and partial weight-bearing was allowed. A hinged knee brace was used for a period of 5 months postoperatively. Second-look arthroscopy at 30 months showed that the ACL graft had no laceration and an excellent coverage of the synovium. At 36 months after surgery, the side-to-side differences in the anterior laxity was remarkably improved. The operated knee showed negative Lachman test and had a full range of motion. CONCLUSIONS: To the best of our knowledge, this represents the first report of anatomic double-bundle ACL reconstruction in patients with hEDS and demonstrates excellent clinical and functional outcomes.
• Four-dimensional computed tomography evaluation of shoulder joint motion in collegiate baseball pitchers.
  Daisuke Momma; Alejandro A Espinoza Orías; Tohru Irie; Tomoyo Irie; Eiji Kondo; Norimasa Iwasaki; Nozomu Inoue
  Scientific reports, 12, 1, 3231, 3231, 2022年02月25日, ［査読有り］, ［筆頭著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, The purpose of this study is to evaluate the glenohumeral contact area, center of glenohumeral contact area, and center of humeral head during simulated pitching motion in collegiate baseball pitchers using four-dimensional computed tomography (4D CT). We obtained 4D CT data from the dominant and non-dominant shoulders of eight collegiate baseball pitchers during the cocking motion. CT image data of each joint were reconstructed using a 3D reconstruction software package. The glenohumeral contact area, center of glenohumeral contact area, center of humeral head, and oblateness of humeral head were calculated from 3D bone models using customized software. The center of glenohumeral contact area translated from anterior to posterior during maximum external rotation to maximum internal rotation (0.58 ± 0.63 mm on the dominant side and 0.99 ± 0.82 mm on the non-dominant side). The center of humeral head translated from posterior to anterior during maximum external rotation to maximum internal rotation (0.76 ± 0.75 mm on the dominant side and 1.21 ± 0.78 mm on the non-dominant side). The increase in anterior translation of the center of glenohumeral contact area was associated with the increase in posterior translation of the center of humeral head. Also, the increase in translation of the center of humeral head and glenohumeral contact area were associated with the increase in oblateness of the humeral head. 4D CT analyses demonstrated that the center of humeral head translated in the opposite direction to that of the center of glenohumeral contact area during external rotation to internal rotation in abduction in the dominant and non-dominant shoulders. The oblateness of the humeral head may cause this diametric translation. 4D CT scanning and the software for bone surface modeling of the glenohumeral joint enabled quantitative assessment of glenohumeral micromotion and be used for kinematic evaluation of throwing athletes.
• Stress distribution pattern in the distal radioulnar joint before and after ulnar shortening osteotomy in patients with ulnar impaction syndrome
  Kazutoshi Hontani; Yuichiro Matsui; Daisuke Kawamura; Atsushi Urita; Daisuke Momma; Hiroki Hamano; Norimasa Iwasaki
  Scientific Reports, 11, 1, 17891, 17891, Springer Science and Business Media LLC, 2021年12月, ［国際誌］
  英語, 研究論文（学術雑誌）, Ulnar shortening osteotomy (USO) for ulnar impaction syndrome potentially leads to degenerative changes of the distal radioulnar joint (DRUJ). This study was performed to evaluate the effect of the sigmoid notch morphology on the stress distribution pattern of the DRUJ using computed tomography (CT) osteoabsorptiometry (CT-OAM). We reviewed the pre- and postoperative transverse CT images of 15 wrists that had undergone USO. The examined wrists were classified into two groups based on the sigmoid notch morphology: the linear-type notch (type L) and the curved-type notch (type C). We calculated and statistically compared the percentage of the high-density area (%HDA) in each divided region of the sigmoid notch. In type L, %HDA was significantly larger in the distal-dorsal region of the sigmoid notch before USO. Postoperatively, in type L, no specific regions showed a significantly different %HDA. In type C, %HDA was significantly larger in the distal-volar region of the sigmoid notch before USO. Postoperatively, %HDA of type C was significantly larger in the proximal-volar region. Our results suggest that in patients with ulnar impaction syndrome, morphological evaluation of the sigmoid notch can serve as a predictor of osteoarthritis in the DRUJ with or without USO.
• Computed tomography revealed the correlation between radiolucency and alignment of all-polyethylene pegged glenoid component more than 10 years after total shoulder arthroplasty in the Japanese population.
  Yuki Matsui; Daisuke Momma; Naoki Suenaga; Atsushi Urita; Chika Yoshioka; Naomi Oizumi; Norimasa Iwasaki
  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 28, 1, 131, 137, 2021年11月24日, ［国内誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Anatomical total shoulder arthroplasty (TSA) provides successful long-term outcomes but complications can occur after 10 years that require revision. Computed tomography (CT) is a useful tool for assessing radiolucent lines around the glenoid component of TSA; however, the merits of long-term post-TSA follow up with CT are unclear. The purpose of this study was to evaluate the long-term outcomes after TSA of Japanese population and to identify factors related to radiolucency around the glenoid component using CT. METHODS: A retrospective review was conducted of TSA patients who had completed at least 10 years of clinical follow up. Radiographs and CT images of the affected shoulder obtained at the last follow up were evaluated for radiolucent lines around the stem and each peg, superior inclination and retroversion of the glenoid component, subluxation index, and critical shoulder angle (CSA). Shoulder ROM, Constant-Murley score and UCLA score were compared between the preoperative and last follow up period. RESULTS: Eighteen shoulders in 16 patients met the inclusion criteria. Mean patient age was 61 years, mean follow up period was 137 months, and mean Yian CT score was 19%. CT score was significantly highest in pegs located inferiorly (p < 0.05). Mean glenoid superior inclination was 12.6°, retroversion was -0.3°, subluxation index was 46%, and CSA was 33.7°. Glenoid superior inclination was significantly lower (p = 0.007) in shoulders with possible loosening than in cases with no loosening (5.0° vs 15.6°). Mean Constant score and UCLA score improved significantly after TSA, from 25.8 to 10.7 points preoperatively to 70.1 and 28.9 points postoperatively, respectively. Mean shoulder flexion, internal rotation, and external rotation also showed improvement postoperatively. CONCLUSION: TSA provides good long-term outcomes. Radiolucency was present most frequently around the inferior pegs of the glenoid component. Glenoid superior inclination may affect the formation of radiolucent lines around glenoid pegs. LEVEL OF EVIDENCE: Level IV; Case Series; Treatment study.
• Changes in elbow joint contact area in symptomatic valgus instability of the elbow in baseball players.
  Kyosuke Numaguchi; Daisuke Momma; Yuki Matsui; Jun Oohinata; Takayoshi Yamaguchi; Nozomu Inoue; Eiji Kondo; Norimasa Iwasaki
  Scientific reports, 11, 1, 19782, 19782, 2021年10月05日, ［査読有り］, ［責任著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, The aim of this study was to evaluate the joint contact area of the dominant side and that of the non-dominant side without valgus instability in symptomatic pitchers. Ten symptomatic elbow medial ulnar collateral ligament (UCL) deficient baseball pitchers participated in this study. Computed tomography (CT) data from the dominant and non-dominant elbows were obtained with and without elbow valgus stress. The CT imaging data of each elbow joint were reconstructed using a 3D reconstruction software package, and the radiocapitellar and ulnohumeral joint contact areas were calculated. The center of the contact area and the translation from the position without stress to the position with valgus stress were also calculated. With elbow valgus stress, the contact area changed, and the center of the radiocapitellar joint contact area translated significantly more laterally in the dominant elbow than in the non-dominant elbow (p = 0.0361). In addition, the center of the ulnohumeral joint contact area translated significantly more posteriorly in the dominant elbow than in the non-dominant elbow (p = 0.0413). These changes in contact areas could be the reason for cartilage injury at the posterior trochlea in pitchers with UCL deficiency.
• Medial closed-wedge distal femoral osteotomy with local bone grafts for large collapsed steroid-induced osteonecrosis of the lateral femoral condyle: A case report.
  Takuma Kaibara; Eiji Kondo; Masatake Matsuoka; Koji Iwasaki; Tomohiro Onodera; Daisuke Momma; Norimasa Iwasaki
  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 28, 6, 1470, 1477, 2021年08月04日, ［国内誌］
  英語
• Stress-Distribution Pattern Across the Glenohumeral Joint in Collegiate and Professional Baseball Players: A Computed Tomography Osteoabsorptiometry Study.
  Kyosuke Numaguchi; Daisuke Momma; Yuki Matsui; Masashi Yokota; Jun Oohinata; Eiji Kondo; Norimasa Iwasaki
  Orthopaedic journal of sports medicine, 9, 6, 23259671211009185, 23259671211009185, 2021年06月, ［査読有り］, ［責任著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The influence of long-term loading conditions on the articular surfaces of the glenohumeral joint can be determined by measuring stress-distribution patterns. Long-term pitching activity changes the stress distribution across the glenohumeral joint surface; however, the influence of competitive level on stress-distribution patterns remains unclear. PURPOSE: To use computed tomography (CT) osteoabsorptiometry (CTOAM) to evaluate the distribution of subchondral bone density across the glenohumeral joint in collegiate and professional baseball players as well as to determine the effects of pitching activity on the articular surfaces. STUDY DESIGN: Descriptive laboratory study. METHODS: We evaluated 73 shoulders in 50 baseball players. CT imaging data were obtained from the dominant-side shoulder of 12 professional pitchers (PP group) and 15 professional fielders (PF group). CT imaging data were also obtained from both shoulders of 12 asymptomatic collegiate pitchers (CP group) and 11 collegiate fielders (CF group). The pattern of distribution of subchondral bone density across the articular surfaces of each glenohumeral joint was assessed by CTOAM. As a measure of bone density, the mean Hounsfield units (HU) were obtained for each joint surface, and the absolute values of the dominant shoulder were compared for each group. RESULTS: Stress-distribution patterns over the articular surfaces differed between the dominant and nondominant sides in the CP group as well as between both collegiate groups versus the PP group. In the CP group, the mean HU of the humeral head surface were greater on the nondominant versus dominant side (P = .035). On the dominant side, the mean HU of the humeral head surface and glenoid were greater in the CP versus the PP group (P = .001 and .027, respectively). CONCLUSION: Stress distribution on the articular surface of the glenohumeral joint was affected by pitching ability and competitive level. Our analysis indicates that the traction force on the glenohumeral joint surface might be greater than compression force during pitching. CLINICAL RELEVANCE: The present findings suggest that pitching activity results in low stress to the articular surfaces of the glenohumeral joint. This supports the notion that mechanical conditions play a crucial role in the etiology of disorders specific to pitching activity.
• Acellular Cartilage Repair Technique Based on Ultrapurified Alginate Gel Implantation for Advanced Capitellar Osteochondritis Dissecans.
  Daisuke Momma; Tomohiro Onodera; Daisuke Kawamura; Atsushi Urita; Yuichiro Matsui; Rikiya Baba; Tadanao Funakoshi; Makoto Kondo; Toshiya Endo; Eiji Kondo; Norimasa Iwasaki
  Orthopaedic journal of sports medicine, 9, 3, 2325967121989676, 2325967121989676, 2021年03月, ［査読有り］, ［筆頭著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: One of the most important limitations of osteochondral autograft transplant is the adverse effect on donor sites in the knee. Ultrapurified alginate (UPAL) gel is a novel biomaterial that enhances hyaline-like cartilage repair for articular defects. To avoid the need for knee cartilage autografting when treating osteochondritis dissecans (OCD) of the capitellum, we developed a surgical procedure involving a bone marrow stimulation technique (BMST) augmented by implantation of UPAL gel. HYPOTHESIS: BMST augmented by UPAL gel implantation improves the cartilage repair capacity and provides satisfactory clinical outcomes in OCD of the capitellum. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: A total of 5 athletes with advanced capitellar OCD in the dominant elbow underwent BMST augmented by implantation of UPAL gel. The osteochondral defects were filled with UPAL gel after BMST. At a mean follow-up of 97 weeks, all patients were evaluated clinically and radiographically. RESULTS: At final follow-up, all 5 patients had returned to competitive-level sports, and 4 patients were free from elbow pain. The mean Timmerman-Andrews score significantly improved from 100 to 194 points. Radiographically, all patients exhibited graft incorporation and a normal contour of the subchondral cortex. Magnetic resonance imaging showed that the preoperative heterogeneity of the lesion had disappeared, and the signal intensity had returned to normal. Arthroscopic examinations consistently exhibited improvement in the International Cartilage Regeneration and Joint Preservation Society (ICRS) grade of lesions from 3 or 4 to 1 or 2 in 4 patients at 85 weeks postoperatively. Histologic analysis of biopsy specimens revealed an average total ICRS Visual Assessment Scale II histologic score of 1060. CONCLUSION: The acellular cartilage repair technique using UPAL gel for advanced capitellar OCD provided satisfactory clinical and radiographic results. The present results suggest that this novel technique is a useful, minimally invasive approach for treating cartilaginous lesions in athletes.
• 3次元computed tomographyを用いた高位脛骨骨切り術前後の膝蓋骨高位の評価 内側楔状開大式と逆V字型の比較
  土橋 晋也; 菱村 亮介; 松岡 正剛; 小野寺 智洋; 藤田 勝久; 岩崎 倫政; 岩崎 浩司; 門間 太輔; 近藤 英司; 井上 望
  北海道整形災害外科学会雑誌, 63, 140th suppl, 75, 75, 北海道整形災害外科学会, 2021年
  日本語
• Stress Distribution Patterns Across the Shoulder Joint in Gymnasts: A Computed Tomography Osteoabsorptiometry Study.
  Daisuke Momma; Wataru Iwamoto; Kaori Endo; Kazuki Sato; Norimasa Iwasaki
  Orthopaedic journal of sports medicine, 8, 11, 2325967120962103, 2325967120962103, 2020年11月, ［査読有り］, ［筆頭著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The distribution pattern of subchondral bone density is an indicator of stress distribution over a joint surface under long-term physiologic loading. The biomechanical characteristics of the articular surfaces of the shoulder joint in gymnasts can be determined by measuring this distribution pattern. PURPOSE: To evaluate the distribution of subchondral bone density across the shoulder joint in male collegiate gymnasts and to determine the effects of gymnastic activities on its articular surfaces under long-term loading conditions using computed tomography osteoabsorptiometry (CTOAM). STUDY DESIGN: Descriptive laboratory study. METHODS: CT image data were obtained from both shoulders of 12 asymptomatic male collegiate gymnasts (gymnast group; mean age, 19.4 years; range, 18-22 years) and 10 male collegiate volunteers (control group; mean age, 20.2 years; range, 18-22 years). The distribution pattern of subchondral bone density across the articular surfaces of each shoulder joint was assessed by CTOAM. Quantitative analysis was performed of the locations and percentages of high-density areas on the articular surface. RESULTS: Stress distribution patterns over the articular surfaces differed between the gymnasts and the controls. In the gymnasts, high-density areas were detected on the posterosuperior articular surface of the humeral head and the anterosuperior and/or posterosuperior articular surface of the glenoid. Mean bone density was greater in the gymnasts than in the controls (P < .0001). CONCLUSION: Stress distribution over the articular surfaces of the shoulder joint was affected by gymnastic activities. Stress was concentrated over the superior part of the glenohumeral joint in male collegiate gymnasts. CLINICAL RELEVANCE: The present findings suggest that gymnastic activities increase stress to the articular surfaces of the superior glenohumeral joint. This supports the notion that mechanical conditions play a crucial role in the origin of disorders particular to gymnastic activities.
• Long-term Stress Distribution Patterns Across the Ankle Joint in Soccer Players: A Computed Tomography Osteoabsorptiometry Study.
  Junki Shiota; Daisuke Momma; Takayoshi Yamaguchi; Norimasa Iwasaki
  Orthopaedic journal of sports medicine, 8, 11, 2325967120963085, 2325967120963085, 2020年11月, ［査読有り］, ［責任著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The distribution pattern of subchondral bone density is considered to accurately reflect the stress distribution over a joint under long-term physiologic loading. The biomechanical characteristics of the surface of the ankle joint in soccer players can be determined by measuring this distribution pattern under long-term loading. PURPOSE: To evaluate the distribution of subchondral bone density across the ankle joint in soccer players and to determine the effects of soccer activities, including kicking motion, on the ankle joint surface under long-term loading conditions by computed tomography (CT) osteoabsorptiometry (CTOAM). STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: CT imaging data were obtained from both ankles of 10 soccer players (soccer group) and 10 nonathletic volunteers (control group). The distribution patterns of subchondral bone density across the articular surface of the ankle joints were assessed by CTOAM. Quantitative analysis was performed of the locations and percentages of high-density areas on the articular surface. RESULTS: Stress distribution patterns over the ankle joint differed between the soccer players and controls. In the soccer players, the high-density areas were found in the anterior part of the distal tibia and proximal talus as well as the distal fibula. The percentages of high-density areas were greater in the soccer players compared with controls (P < .0001). CONCLUSION: Stress distribution over the articular surface of the ankle joint was affected by soccer activities. A high stress concentration was seen in soccer players in the anterior part of the tibia and talus and in the fibula; such excessive stress may lead to anterior impingement.
• Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction.
  Takuma Kaibara; Eiji Kondo; Masatake Matsuoka; Koji Iwasaki; Tomohiro Onodera; Daisuke Momma; Naoki Seito; Susumu Mikami; Norimasa Iwasaki
  BMC musculoskeletal disorders, 21, 1, 494, 494, 2020年07月27日, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Articular surface damage commonly associated with rupture of the anterior cruciate ligament (ACL). Large osteochondral defect, which consists of a severe depression fracture and a large cartilage defect, need to be treated due to deformation of the articular surface as it can impact the clinical outcome of ACL reconstruction. Although autologous chondrocyte implantation is one of the useful options in such cases, it can be questioned whether the reconstruction of the ACL and osteochondral defect should be performed in one procedure alone. CASE PRESENTATION: We report a case of a 38-year-old male with a deep depression fracture extending to the edge of the lateral femoral condyle associated with ACL injury after twisting his right knee while skiing. The patient was successfully treated with tissue-engineered cartilage transplantation covered by the periosteum with an iliac bone graft combined with anatomic double-bundle ACL reconstruction. Histopathological examination of the transplanted cartilage taken at second-look arthroscopy showed a cartilage-like tissue in the middle to deep zone in which the extracellular matrix was largely stained with Safranin O. The patient was able to return to his previous level of skiing activity without any experience of knee pain. Magnetic resonance imaging at 4 years after surgery showed that the graft integrated to the border zone and subchondral bone. The operated knee showed negative Lachman test and had a full range of motion. CONCLUSIONS: To our knowledge, this is the first report of anatomic double-bundle ACL reconstruction with tissue-engineered cartilage transplantation and an iliac bone graft to restore the lateral edge of the femoral condyle.
• Long-term stress distribution patterns across the wrist joint in gymnasts assessed by computed tomography osteoabsorptiometry.
  Daisuke Momma; Wataru Iwamoto; Norimasa Iwasaki
  The Journal of hand surgery, European volume, 44, 10, 1098, 1100, 2019年12月, ［査読有り］, ［筆頭著者］, ［国際誌］
  英語
• Depletion of glycosphingolipids induces excessive response of chondrocytes under mechanical stress
  Matsubara S; Onodera T; Maeda E; Momma D; Matsuoka M; Homan K; Ohashi T; Iwasaki N
  Journal of Biomechanics, 94, 22, 30, 2019年09月20日, ［査読有り］, ［国際誌］
  英語, Glycosphingolipids (GSLs) are ubiquitous membrane components that play an indispensable role in maintaining chondrocyte homeostasis. To gain better insight into roles of GSLs, we studied the effects of GSL-deletion on the physiological responses of chondrocytes to mechanical stress. Mice lacking Ugcg gene (Ugcg-/-) were genetically generated to obtain GSL-deficient mice, and their chondrocytes from the joints were used for functional analyses in vitro culture experiments. The cells were seeded in a three-dimensional collagen gel and subjected to 5%, 10% or 16% cyclic tensile strain for either 3 or 24 h. The gene expressions of chondrocyte anabolic and catabolic factors, and the induction of Ca2+ signaling were analyzed. Our results revealed that chondrocytes derived from GSL-deficient mice exhibited an elevation in the expression of catabolic factors (ADAMTS-5, MMP-13) following the exposure to strain with amplitudes of 10%. Likewise, applying cyclic tensile strain with these amplitudes resulted in an increased Ca2+ oscillation ratio in chondrocytes from GSL-deficient as compared to the ratio from control mice. These results demonstrated that deletion of GSL stimulated the catabolic responses of chondrocytes to mechanical stress via the augmentation of the sensitivity to mechanical stress that may lead to the cartilage deterioration. These findings suggest that the regulation of the physiological responses of chondrocytes by GSLs could be a potential target in a therapeutic intervention in osteoarthritis.
• Chondrogenic differentiation of mouse induced pluripotent stem cells (iPSCs) using the three-dimensional culture with ultra-purified alginate gel (UPAL gel).
  Hontani K; Onodera T; Terashima M; Momma D; Matsuoka M; Baba R; Joutoku Z; Matsubara S; Homan K; Hishimura R; Xu L; Iwasaki N
  Journal of biomedical materials research. Part A, 107, 5, 1086, 1093, 2019年05月, ［査読有り］, ［国際誌］
  英語, As articular cartilages have rarely healed by themselves because of their characteristics of avascularity and low cell density, surgical intervention is ideal for patients with cartilaginous injuries. Because of structural characteristics of the cartilage tissue, a three-dimensional culture of stem cells in biomaterials is a favorable system on cartilage tissue engineering. Induced pluripotent stem cells (iPSCs) are a new cell source in cartilage tissue engineering for its characteristics of self-renewal capability and pluripotency. However, the optimal cultivation condition for chondrogenesis of iPSCs is still unknown. Here we show that a novel chondrogenic differentiation method of iPSCs using the combination of three-dimensional cultivation in ultra-purified alginate gel (UPAL gel) and multi-step differentiation via mesenchymal stem cell-like cells (iPS-MSCs) could efficiently and specifically differentiate iPSCs into chondrocytes. The iPS-MSCs in UPAL gel culture sequentially enhanced the expression of chondrogenic marker without the upregulation of that of osteogenic and adipogenic marker and histologically showed homogeneous chondrogenic extracellular matrix formation. Our results suggest that the pluripotency of iPSCs can be controlled when iPSCs are differentiated into iPS-MSCs before embedding in UPAL gel. These results lead to the establishment of an efficient three-dimensional system to engineer artificial cartilage tissue from iPSCs for cartilage regeneration. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1086-1093, 2019.
• CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults.
  Joutoku Z; Onodera T; Matsuoka M; Homan K; Momma D; Baba R; Hontani K; Hamasaki M; Matsubara S; Hishimura R; Iwasaki N
  Scientific reports, 9, 1, 5165, 5165, 2019年03月26日, ［査読有り］, ［国際誌］
  英語, Juvenile tissue healing is capable of extensive scarless healing that is distinct from the scar-forming process of the adult healing response. Although many growth factors can be found in the juvenile healing process, the molecular mechanisms of juvenile tissue healing are poorly understood. Here we show that juvenile mice deficient in the chemokine receptor CCR7 exhibit diminished large-scale healing potential, whereas CCR7-depleted adult mice undergo normal scar-forming healing similar to wild type mice. In addition, the CCR7 ligand CCL21 was transiently expressed around damaged cartilage in juvenile mice, whereas it is rarely expressed in adults. Notably, exogenous CCL21 administration to adults decreased scar-forming healing and enhanced hyaline-cartilage repair in rabbit osteochondral defects. Our data indicate that the CCL21/CCR7 axis may play a role in the molecular control mechanism of juvenile cartilage repair, raising the possibility that agents modulating the production of CCL21 in vivo can improve the quality of cartilage repair in adults. Such a strategy may prevent post-traumatic arthritis by mimicking the self-repair in juvenile individuals.
• Alteration in stress distribution patterns through the elbow joint in professional and college baseball pitchers: Using computed tomography osteoabsorptiometry.
  Daisuke Momma; Tadanao Funakoshi; Kaori Endo; Masashi Yokota; Kazuhiro Fujisaki; Norimasa Iwasaki
  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 23, 6, 948, 952, 2018年11月, ［査読有り］, ［筆頭著者］, ［国内誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Long-term pitching activities change the stress distribution across the elbow joint surface in living subjects, however the influence of the different strength of stress on the stress distribution patterns remain unclear. The aims of this study were to evaluate the distribution of subchondral bone density across the elbow joint in different levels of pitchers, and to reveal the influence of the strength of stress on the elbow joint surface under long-term loading conditions of baseball pitching. METHODS: The current analysis was performed using computed tomography (CT) image data obtained from the throwing side elbow of 12 nonthrowing athletes (controls), 15 college baseball pitchers (college group) and 13 professional baseball pitchers (professional group). The distribution patterns of subchondral bone density through the articular surface of the elbow joints were assessed using a CT osteoabsorptiometry method. The quantitative analysis was based on location and percentages of high-density area on the articular surface. RESULTS: High-density area in the college and professional groups were found in the anterior part of the captellum, posterior part of the trochlea and radial head. In the professional group, the percentages of high-density area in the anterior part of the capitellum, posterior part of the trochlea, radial head and olecranon were significantly greater than in the college group. CONCLUSIONS: Stress distribution on the articular surface of the elbow joint was affected by pitching abilities or competitive levels. Our analysis indicates that high strength of stress in professional baseball players produce potential risk of elbow injuries.
• Coordinated existence of multiple gangliosides is required for cartilage metabolism.
  Momma D; Onodera T; Homan K; Matsubara S; Sasazawa F; Furukawa J; Matsuoka M; Yamashita T; Iwasaki N
  Osteoarthritis and cartilage, 2018年11月, ［査読有り］, ［筆頭著者］
• Autologous Osteochondral Mosaicplasty for Centrally and Laterally Located, Advanced Capitellar Osteochondritis Dissecans in Teenage Athletes: Clinical Outcomes, Radiography, and Magnetic Resonance Imaging Findings.
  Funakoshi T; Momma D; Matsui Y; Kamishima T; Matsui Y; Kawamura D; Nagano Y; Iwasaki N
  The American journal of sports medicine, 46, 8, 1943, 1951, 2018年07月, ［査読有り］
• Anatomic analysis of the whole articular capsule of the shoulder joint, with reference to the capsular attachment and thickness.
  Momma D; Nimura A; Muro S; Fujishiro H; Miyamoto T; Funakoshi T; Mochizuki T; Iwasaki N; Akita K
  Journal of experimental orthopaedics, 5, 1, 16, 2018年06月, ［査読有り］, ［筆頭著者］
• Optimal administration frequency and dose of teriparatide for acceleration of biomechanical healing of long-bone fracture in a mouse model.
  Ota M; Takahata M; Shimizu T; Momma D; Hamano H; Hiratsuka S; Amizuka N; Hasegawa T; Iwasaki N
  Journal of bone and mineral metabolism, 37, 2, 256, 263, 2018年05月, ［査読有り］
• Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice
  Masatake Matsuoka; Tomohiro Onodera; Kentaro Homan; Fumio Sasazawa; Jun-ichi Furukawa; Daisuke Momma; Rikiya Baba; Kazutoshi Hontani; Zenta Joutoku; Shinji Matsubara; Tadashi Yamashita; Norimasa Iwasaki
  SCIENTIFIC REPORTS, 7, 43729, 2017年03月, ［査読有り］
  英語, 研究論文（学術雑誌）
• Alteration of Stress Distribution Patterns in Symptomatic Valgus Instability of the Elbow in Baseball Players: A Computed Tomography Osteoabsorptiometry Study
  Tadanao Funakoshi; Kozo Furushima; Daisuke Momma; Kaori Endo; Yuichiro Abe; Yoshiyasu Itoh; Kazuhiro Fujisaki; Shigeru Tadano; Norimasa Iwasaki
  AMERICAN JOURNAL OF SPORTS MEDICINE, 44, 4, 989, 994, 2016年04月, ［査読有り］
  英語, 研究論文（学術雑誌）
• A Novel Bone Marrow Stimulation Technique Augmented by Administration of Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model.
  Baba R; Onodera T; Momma D; Matsuoka M; Hontani K; Elmorsy S; Endo K; Todoh M; Tadano S; Iwasaki N
  Tissue engineering. Part C, Methods, 21, 12, 1263, 1273, 2015年12月, ［査読有り］
• An Articular Cartilage Repair Model in Common C57Bl/6 Mice.
  Matsuoka M; Onodera T; Sasazawa F; Momma D; Baba R; Hontani K; Iwasaki N
  Tissue engineering. Part C, Methods, 21, 8, 767, 772, 2015年08月, ［査読有り］
• Alterations in stress distribution patterns through the forearm joint surface of the elbow in baseball players assessed using computed tomography osteoabsorptiometry.
  Momma D; Iwasaki N; Oizumi N; Fujisaki K; Funakoshi T; Abe Y; Kamishima T; Tadano S; Minami A
  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 17, 3, 253, 260, 2012年05月, ［査読有り］, ［筆頭著者］, ［国内誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The distribution of subchondral bone density well reflects long-term resultant stress acting on an articular surface in living joints. Consequently, a measurement of the distribution pattern can determine the stress distribution across the elbow joint surface under long-term loading conditions of baseball pitching. Our purpose was to elucidate the characteristic alterations in the distribution pattern of subchondral bone density across the forearm bones of the elbow with pitching activities. The hypothesis is that pitching activities would change the stress distribution in living subjects. METHODS: The analysis was performed using computed tomography (CT) images obtained from the dominant elbow of ten nonthrowing athletes (control group), ten college baseball fielders (fielder group), and ten college baseball pitchers (pitcher group). The distribution pattern of subchondral bone density through the articular surface of the proximal radius and ulna bones was assessed using CT osteoabsorptiometry. RESULTS: The maximum density area was located in the posterior part of the trochlea notch in all study participants. This maximum density area was significantly increased in the baseball groups compared with that in the control group. The pitcher group also showed a significant distribution of the maximum density area in the anterior part of the radial head. CONCLUSION: Our analysis indicates that pitching activities increase actual stress on the articular surface not only in the posterior part of the trochlea notch but also in the anterior part of the radial head. The stress across the elbow may be expanded from the ulnohumeral to the radiohumeral joint by repetitive pitching activities in living subjects.
• Long-term stress distribution patterns across the elbow joint in baseball players assessed by computed tomography osteoabsorptiometry.
  Daisuke Momma; Norimasa Iwasaki; Naomi Oizumi; Hiroki Nakatsuchi; Tadanao Funakoshi; Tamotsu Kamishima; Shigeru Tadano; Akio Minami
  The American journal of sports medicine, 39, 2, 336, 41, 2011年02月, ［査読有り］, ［筆頭著者］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: The distribution pattern of subchondral bone density is considered to highly reflect the stress distribution across a joint under long-term physiologic loading conditions. Therefore, the biomechanical characteristics over the elbow joint surface under long-term loading conditions of baseball pitching can be determined by a measurement of the distribution pattern. HYPOTHESIS: Stress distribution over the elbow joint surface alters with long-term pitching activities. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: Computed tomography (CT) imaging data from the dominant elbow of 10 nonthrowing athletes, 10 college baseball fielders, and 10 college baseball pitchers were collected for the current analysis. The distribution of subchondral bone density through the distal articular surface of the humerus was measured using a CT osteoabsorptiometry method. The quantitative analysis of the obtained data focused on location and size of the maximum density area at the articular surface. RESULTS: The maximum density area of subchondral bone across the articular surface of the distal humerus was located in the posterior part of the trochlea in all subjects. This maximum density area was significantly increased in the pitcher group, compared with that in other groups. Additionally, the pitcher group demonstrated a significant distribution of the maximum density area in the anterior part of the capitellum. CONCLUSION: The results indicate that actual stress across the elbow is concentrated in the posterior part of the trochlea in humans. Baseball pitching may produce excessive or repetitive stress against not only this part, but also the anterior part of the capitellum. The majority of osteochondritis dissecans lesions affecting the elbow are found in the anterior part of the capitellum in throwing athletes. The results may support an important role of mechanical conditions in the cause of elbow osteochondritis dissecans.
• Giant-cell tumor of the distal ulna treated by wide resection and ulnar support reconstruction: a case report.
  Akio Minami; Norimasa Iwasaki; Kinya Nishida; Makoto Motomiya; Katsuhisa Yamada; Daisuke Momma
  Case reports in medicine, 2010, 871278, 871278, 2010年, ［国際誌］
  英語, 研究論文（学術雑誌）, Giant-cell tumor of bone occurred in the distal end of the ulna is extremely uncommon. A 23-year-old male had a giant-cell tumor occurred in the distal end of the ulna. After wide resection of the distal segment of the ulna including giant-cell tumor, ulnar components of the wrist joint were reconstructed with modified Sauvé-Kapandji procedure using the iliac bone graft, preserving the triangular fibrocartilage complex and ulnar collateral ligament in order to maintain ulnar support of the wrist, and the proximal stump of the resected ulna was stabilized by tenodesis using the extensor carpi ulnaris tendon. One year after operation, the patient's wrist was pain-free and had a full range of motion. Postoperative X-rays showed no abnormal findings including recurrence of the giant-cell tumor and ulnar translation of the entire carpus. The stability of the proximal stump of the distal ulna was also maintained.

• 変形性関節症発症の初期段階を捉える糖鎖生物学-高マンノース型N型糖鎖の変化とコアフコシル化による軟骨恒常性維持機構の新展開
  宝満健太郎; 小野寺智洋; 花松久寿; 古川潤一; 古川潤一; 門間太輔; 松岡正剛; 岩崎倫政, 北海道整形災害外科学会雑誌(Web), 66, 2, 2025年
• 変形性手関節症に対する全人工手関節手根骨ステムの至適なエントリーポイントの検討
  遠藤健; 河村太介; 松井雄一郎; 門間太輔; 河村太介; 松井雄一郎; 門間太輔; 鈴木智亮; 木田博朗; 五月女慧人; 岩崎倫政, 日本整形外科学会雑誌, 98, 2, 2024年
• 肘頭骨折術後に多様な神経障害を呈した1例
  吉野豪起; 遠藤健; 鈴木智亮; 木田博朗; 五月女慧人; 門間太輔; 松井雄一郎; 岩崎倫政, 北海道整形外科外傷研究会会誌, 39, 2024年
• 当科におけるSNAC wristの治療成績
  五月女慧人; 松井雄一郎; 松井雄一郎; 木田博朗; 鈴木智亮; 遠藤健; 門間太輔; 岩崎倫政, 日本整形外科学会雑誌, 98, 3, 2024年
• RSAのベースプレート設置におけるPSIおよびナビゲーションの有用性の検討
  木田博朗; 門間太輔; 瓜田淳; 松居祐樹; 鈴木智亮; 五月女慧人; 岩崎倫政, 日本整形外科学会雑誌, 98, 3, 2024年
• 当院におけるプライザー病の治療成績に関する検討
  木田博朗; 遠藤健; 遠藤努; 岩崎倫政; 松井雄一郎; 河村太介; 門間太輔, 北海道整形災害外科学会, 143rd, 2024年
• リバース型人工肩関節置換術における関節内止血剤投与の効果検討
  五月女慧人; 木田博朗; 鈴木智亮; 遠藤健; 松井雄一郎; 岩崎倫政; 門間太輔; 松居祐樹, 北海道整形災害外科学会, 143rd, 2024年
• GPSガイド下RSAにおける上腕骨後方関節包剥離の重要性
  五月女慧人; 木田博朗; 鈴木智亮; 松井雄一郎; 岩崎倫政; 門間太輔, 北海道整形災害外科学会, 143rd, 2024年
• 変形性手関節症に対する全人工手関節手根骨ステムの至適なエントリーポイントの検討
  遠藤健; 鈴木智亮; 木田博朗; 五月女慧人; 岩崎倫政; 河村太介; 松井雄一郎; 門間太輔, 北海道整形災害外科学会, 143rd, 2024年
• RSAのベースプレート設置におけるPSIおよびナビゲーション使用の有用性
  木田博朗; 門間太輔; 瓜田淳; 松居祐樹; 五月女慧人; 岩崎倫政, 日本関節病学会誌(Web), 43, 2, 2024年
• 4D-CTを用いた肩鎖関節不安定性の評価
  門間太輔; 木田博朗; 沼口京介; 五月女慧人; 入江朋世; 近藤英司; 岩崎倫政, 日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集, 51st-21st, 2024年
• RSAにおける上腕骨後方関節包剥離の重要性-GPSガイドでの検証-
  五月女慧人; 門間太輔; 木田博朗; 入江朋世; 岩崎倫政, 日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集, 51st-21st, 2024年
• リバース型人工肩関節置換術における関節内止血剤投与の効果検討
  五月女慧人; 門間太輔; 木田博朗; 松居祐樹; 岩崎倫政, 日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集, 51st-21st, 2024年
• 青少年テニス選手における上腕骨後捻角の左右差の調査
  木田博朗; 門間太輔; 池翔太; 沼口京介; 近藤英司; 八木知徳; 岩崎倫政, 日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集, 51st-21st, 2024年
• 当科で過去18年間に経験したPreiser病症例の検討
  木田博朗; 松井雄一郎; 松井雄一郎; 河村太介; 遠藤健; 門間太輔; 遠藤努; 岩崎倫政, 日本手外科学会雑誌(Web), 41, 1, 2024年
• 変形性手関節症に対する全人工手関節手根骨ステムの至適なエントリーポイントの検討
  遠藤健; 河村太介; 松井雄一郎; 松井雄一郎; 門間太輔; 門間太輔; 鈴木智亮; 木田博朗; 五月女慧人; 岩崎倫政, 日本手外科学会雑誌(Web), 41, 1, 2024年
• 当科の過去13年間におけるSNAC wristの治療成績
  五月女慧人; 松井雄一郎; 松井雄一郎; 木田博朗; 鈴木智亮; 遠藤健; 門間太輔; 岩崎倫政, 日本手外科学会雑誌(Web), 41, 1, 2024年
• 当科の過去13年間におけるSNAC wristの治療成績
  五月女慧人; 松井雄一郎; 木田博朗; 遠藤健; 門間太輔; 岩崎倫政, 日本手外科学会雑誌(Web), 41, 3, 2024年
• 高純度硬化性ゲルを用いた軟骨再生医療法の開発
  小野寺智洋; 門間太輔; 松岡正剛; 岩崎浩司; 近藤英司; 鈴木孝治; 井上雅之; 岩崎倫政, 日本整形外科学会雑誌(CD-ROM), 98, 8, 2024年
• RSAにおけるPSIおよびナビゲーションの有用性の検討
  木田博朗; 門間太輔; 瓜田淳; 松居祐樹; 五月女慧人; 岩崎倫政, 日本肩関節学会学術集会・日本肩の運動機能研究会学術集会抄録集, 50th-20th, 2023年
• リバース型人工肩関節における術前計画ソフトウェアおよび術中ナビゲーションの有用性
  瓜田淳; 木田博朗; 河村太介; 松井雄一郎; 門間太輔; 太田光俊; 芝山浩樹; 岩崎倫政, 日本整形外科学会雑誌, 95, 2, 2021年
• リバース型人工肩関節置換術におけるナビゲーションの有用性
  瓜田淳; 木田博朗; 門間太輔; 松居祐樹; 岩崎倫政; 種市洋, 東日本整形災害外科学会雑誌(Web), 33, 3, 2021年
• ナビゲーションを用いたリバース型人工肩関節の有用性
  木田博朗; 瓜田淳; 門間太輔; 松居祐樹; 岩崎倫政, 日本肩関節学会抄録集, 47th, 2020年
• マウスiPS細胞からの軟骨分化誘導と糖鎖解析を用いた新規バイオマーカーの探索
  本谷 和俊; 小野寺 智洋; 寺島 理代; 門間 太輔; 松岡 正剛; 馬場 力哉; 上徳 善太; 松原 新史; 宝満 健太郎; 菱村 亮介; 金 佑泳; 濱崎 雅成; 徐 亮; 岩崎 倫政, 北海道整形災害外科学会雑誌, 60, 1, 145, 145, 2018年08月
  北海道整形災害外科学会, 日本語
• The candidates of glyco-biomarker of chondrocyte hypertrophy detected by Comprehensive N-glycan profiling.
  Kentaro Homan; Tomohiro Onodera; Jun-ichi Furukawa; Masatake Matsuoka; Daisuke Momma; Rikiya Baba; Kazutoshi Hontani; Zenta Joutoku; Shinji Matsubara; Ryosuke Hishimura; Kim WooYoung; Masanari Hamasaki; Liang Xu; Yuan Tian; Norimasa Iwasaki, The 64th Annual Meeting of Orthopaedic Research Society (ORS), 43, PS2-104, 2018年03月
  英語
• Depletion of Glycoshingolipids Induces the Exvessive Response of Chondrocytes under Mechanical Stress Condition.
  Shinji Matsubara; Tomohiro Onodera; Eijiro Maeda; Momma Daisuke; Masatake Matsuoka; Rikiya Baba; Kazutoshi Hontani; Zenta Joutoku; Kentaro Homan; Toshiro Ohashi; Norimasa Iwasaki, The 64th Annual Meeting of Orthopaedic Research Society (ORS), 43, 19, 2018年03月
  英語
• 高マンノース型糖鎖の変化は早期OAに類似した可逆的軟骨変性を生じさせる
  宝満 健太郎; 小野寺 智洋; 古川 潤一; 門間 太輔; 松岡 正剛; 馬場 力哉; 本谷 和俊; 上徳 善太; 松原 新史; 菱村 亮介; 金 佑泳; 濱崎 雅成; 徐 亮; 田 園; 岩崎 倫政, 北海道整形災害外科学会雑誌, 59, 2, 253, 253, 2018年03月
  北海道整形災害外科学会, 日本語
• CCL21/CCR7 Axis Regulating Juvenile Cartilage Repair Can Enhance Cartilage Healing In Adult.
  Zenta Joutoku; Tomohiro Onodera; Daisuke Momma; Masatake Matsuoka; Rikiya Baba; Kazutoshi Hontani; Shinji Matsubara; Ryosuke Hishimura; Norimasa Iwasaki, The 64th Annual Meeting of Orthopaedic Research Society (ORS), 43, 12, 2018年03月
  英語
• 軟骨細胞肥大分化の包括的N型糖鎖プロファイリングによる糖鎖バイオマーカー探索
  宝満健太郎; 小野寺智洋; 花松久寿; 古川潤一; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 上徳善太; 松原新史; 菱村亮介; 金佑泳; 濱崎雅成; 岩崎倫政, 北海道整形災害外科学会, 134th, 36, 2018年
  日本語
• 関節軟骨の再生医療 CCL21/CCR7は幼若個体での軟骨修復に重要である
  上徳 善太; 小野寺 智洋; 門間 太輔; 松岡 正剛; 馬場 力哉; 本谷 和俊; 松原 新史; 宝満 健太郎; 菱村 亮介; 金 佑泳; 濱崎 雅成; 徐 亮; 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1467, S1467, 2017年08月
  (公社)日本整形外科学会, 日本語
• 関節軟骨の再生医療 マウスiPS細胞の軟骨分化誘導と糖鎖解析を用いた新規バイオマーカーの探索
  本谷 和俊; 小野寺 智洋; 寺島 理代; 門間 太輔; 松岡 正剛; 上徳 善太; 松原 新史; 宝満 健太郎; 菱村 亮介; 濱崎 雅成; 金 佑泳; 徐 亮; 田 園; 岩崎 倫政, 日本整形外科学会雑誌, 91, 8, S1469, S1469, 2017年08月
  (公社)日本整形外科学会, 日本語
• 糖鎖解析を用いたiPS細胞からの軟骨分化における新規バイオマーカーの探索
  本谷和俊; 小野寺智洋; 寺島理代; 門間太輔; 松岡正剛; 馬場力哉; 上徳善太; 松原新史; 宝満健太郎; 菱村亮介; 金佑泳; 濱崎雅成; 徐亮,田園; 岩崎倫政, 第30回日本軟骨代謝学会, 101, 2017年03月
• Identification Of Differentiation Biomarkers For The Chondrogenic Differentiation Of Induced Pluripotent Stem Cells.
  Kazutoshi Hontani; Tomohiro Onodera; Daisuke Momma; Masatake Matsuoka; Rikiya Baba; Zenta Joutoku; Shinji Matsubara; Kentaro Homan; Kentaro Homan; Ryosuke Hishimura; Kim WooYoung; Masanari Hamasaki; Liang Xu; Yuan Tian; Norimasa Iwasaki, The 63th Annual Meeting of Orthopaedic Research Society (ORS), 2017年03月
  英語
• 三次元培養下における伸張ストレス負荷モデルの確立
  松原 新史; 小野寺 智洋; 門間 太輔; 松岡 正剛; 馬場 力哉; 本谷 和俊; 上徳 善太; 宝満 健太郎; キム・ウヨン; 岩崎 倫政, 北海道整形災害外科学会雑誌, 58, 2, 270, 271, 2017年03月
  北海道整形災害外科学会, 日本語
• ガングリオシド欠損はIndian Hedgehog pathwayを介し軟骨の肥大化を抑制する
  松岡 正剛; 小野寺 智洋; 笹沢 史生; 門間 太輔; 馬場 力哉; 本谷 和俊; 上徳 善太; 宝満 健太郎; 岩崎 倫政, 北海道整形災害外科学会雑誌, 58, 2, 269, 270, 2017年03月
  北海道整形災害外科学会, 日本語
• 高マンノース型糖鎖の減少は可逆的軟骨変性を引き起こす
  宝満健太郎; 小野寺智洋; 古川潤一; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 上徳善太; 松原新史; 菱村亮介; KIM Wooyoung; 濱崎雅成; XU Liang; TIAN Yuan; 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 30th, 112, 2017年03月
  日本語
• 軟骨自然治癒過程に発現するCCL21による軟骨修復の検討
  上徳善太; 小野寺智洋; 古川潤一; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 松原新史; 宝満健太郎; 菱村亮介; 岩崎倫政, 第30回日本軟骨代謝学会, 94, 2017年03月
• 高マンノース型糖鎖の減少は可逆的軟骨変性を引き起こす
  宝満健太郎; 小野寺智洋; 古川潤一; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 上徳善太; 松原新史; 菱村亮介; 金佑泳; 濱崎雅成; 徐亮,田園; 岩崎倫政, 第30回日本軟骨代謝学会, 120, 2017年03月
• Depletion Of Gangliosides Enhances Articular Cartilage Repair By Suppressing The Chondrocyte Hypertrophy.
  Masatake Matsuoka; Tomohiro Onodera; Kentaro Homan; Fumio Sasazawa; Daisuke Momma; Rikiya Baba; Kazutoshi Hontani; Zenta Joutoku; Shinji Matsubara; Ryosuke Hishimura; Norimasa Iwasaki, The 63th Annual Meeting of Orthopaedic Research Society (ORS), 2017年03月
  英語
• CCL21 Expressed in Cartilage Repair Process in Immature Mice and Accelerated Cartilage Repair.
  Zenta Joutoku; Tomohiro Onodera; Daisuke Momma; Masatake Matsuoka; Rikiya Baba; Kazutoshi Hontani; Shinji Matsubara; Kentaro Homan; Ryosuke Hishimura; Norimasa Iwasaki, The 63th Annual Meeting of Orthopaedic Research Society (ORS), 2017年03月
  英語
• The enzymatic cleavage of high-mannose type N-glycan induces recoverable cartilage degradation.
  Kentaro Homan; Tomohiro Onodera; Jun-ichi Furukawa; Daisuke Momma; Masatake Matsuoka; Rikiya Baba; Kazutoshi Hontani; Zenta Joutoku; Shinji Matsubara; Ryosuke Hishimura; Kim WooYoung; Masanari Hamasaki; Liang Xu; Norimasa Iwasaki, The 63th Annual Meeting of Orthopaedic Research Society (ORS), 2017年03月
  英語
• 有頭骨部分切除・腱球置換術を施行した有頭骨壊死の1例
  木田博朗; 松井雄一郎; 河村太介; 永野裕介; 船越忠直; 岩崎倫政; 門間太輔; 桑原健; 畑中佳奈子, 北海道整形災害外科学会, 132nd, 2017年
• ultra-purified alginate gel (UPAL gel) を用いたマウスiPS細胞からの軟骨分化誘導
  本谷和俊; 小野寺智洋; 寺島理代; 門間太輔; 松岡正剛; 馬場力哉; 上徳善太; 松原新史; 宝満健太郎; 菱村亮介; 金佑泳; 徐亮; 岩崎倫政, 日本バイオマテリアル学会シンポジウム, 13, 2016年10月
• 骨軟骨再生に特異的に作用するケモカインの網羅的解析
  上徳善太; 小野寺智洋; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 松原新史; 宝満健太郎; 岩崎倫政, 北海道整形災害外科学会雑誌, 58, 1, 82, 83, 2016年10月
  日本語, 会議報告等
• Ultra-purified alginate gel(UPAL gel)を用いたiPS細胞からの軟骨誘導
  本谷 和俊; 小野寺 智洋; 寺島 理代; 門間 太輔; 松岡 正剛; 馬場 力哉; 上徳 善太; 松原 新史; 宝満 健太郎, 北海道整形災害外科学会雑誌, 58, 1, 83, 84, 2016年10月
  北海道整形災害外科学会, 日本語
• 高マンノース型糖鎖構造変化に伴う軟骨変性へのアプローチ
  宝満 健太郎; 小野寺 智洋; 門間 太輔; 松岡 正剛; 馬場 力哉; 本谷 和俊; 松原 新史; 上徳 善太; 岩崎 倫政, 北海道整形災害外科学会雑誌, 58, 1, 83, 83, 2016年10月
  北海道整形災害外科学会, 日本語
• 軟骨細胞の力学的ストレス応答におけるスフィンゴ糖脂質の機能解析
  松原新史; 小野寺智洋; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 上徳善太; 宝満健太郎; 菱村亮介; キムウヨン; 岩崎倫政, 第43回日本臨床バイオメカニクス学会, 2016年09月
  日本語
• The Efficacy of Chondrogenic differentiation with ultra-purified alginate gel (UPAL gel) for mouse iPS cells in vitro and in vivo.
  K. Hontani; T. Onodera; D. Momma; M. Matsuoka; R. Baba; Z. Joutoku; S. Matsubara; K. Homan; R. Hishimura; N. Iwasaki, The13th World Congress of International Chemical Reference Substances (ICRS), 2016年09月
  英語
• 野球選手における肘内側側副靱帯損傷および靱帯再建術が肘関節応力分布に与える影響
  門間太輔; 船越忠直; 古島弘三; 遠藤香織; 但野茂; 藤崎和弘; 岩崎倫政, 日本整形外科学会雑誌, 90, 3, S608, 2016年03月31日
  日本語
• Chondrogenic Differentiation Of Mouse Induced Pluripotent Stem Cells (iPSCs) Using The Three Dimensional Culture With Ultra-purified Alginate Gel (UPAL Gel).
  Kazutoshi Hontani; Tomohiro Onodera; Daisuke Momma; Masatake Matsuoka; Rikiya Baba; Zenta Joutoku; Shinji Matsubara; Kentaro Homan; Ryosuke Hishimura; Kim WooYoung; Norimasa Iwasaki, The 62th Annual Meeting of Orthopaedic Research Society (ORS), 2016年03月
  英語
• Comprehensive Screening of Chemokines Related to Articular Cartilage Repair.
  Zenta Joutoku; Tomohiro Onodera; Daisuke Momma; Masatake Matsuoka; Rikiya Baba; Kazutoshi Hontani; Shinji Matsubara; Kentaro Homan; Ryosuke Hishimura; WooYoung Kim; Norimasa Iwasaki, The 62th Annual Meeting of Orthopaedic Research Society (ORS), 2016年03月
  日本語
• Depletion of Gangliosides Accelerated the Articular Cartilage Repair Through Indian Hedgehog Pathway.
  Masatake Matsuoka; Tomohiro Onodera; Fumio Sasazawa; Daisuke Momma; Rikiya Baba; Kazutoshi Hontani; Zenta Joutoku; Shinji Matsubara; Kentaro Homan; Norimasa Iwasaki, The 62th Annual Meeting of Orthopaedic Research Society (ORS), 2016年03月
  英語
• Depletion of High-mannose Type N-glycans Lead to Cartilage Degradation.
  Kentaro Homan; Tomohiro Onodera; Rikiya Baba; Daisuke Momma; Masatake Matsuoka; Kazutoshi Hontani; Shinji Matsubara; Zenta Joutoku; Ryosuke Hishimura; Kim WooYoung; Norimasa Iwasaki, The 62th Annual Meeting of Orthopaedic Research Society (ORS), 2016年03月
  英語
• ガングリオシド欠損はIndian hedgehog pathwayを介し軟骨の肥大化を抑制する
  松岡正剛; 小野寺智洋; 笹沢史生; 門間太輔; 馬場力哉; 本谷和俊; 上徳善太; 松原新史; 宝満健太郎; 岩崎倫政, 日本軟骨代謝学会プログラム・抄録集, 29th, 136, 2016年02月
  日本語
• 軟骨修復に関連するケモカインの網羅的解析
  上徳善太; 小野寺智洋; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 松原新史; 宝満健太郎; 菱村亮介; 岩崎倫政, 第29回日本軟骨代謝学会, 90, 8, 138, 2016年02月
  日本語
• 三次元培養下における伸長ストレス負荷モデルの確立
  松原新史; 小野寺智洋; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 上徳善太; 宝満健太郎; 菱村亮介; キムウヨン; 岩崎倫政, 第29回日本軟骨代謝学会, 129, 2016年02月
  日本語
• Ultra-purified alginate gel (UPAL gel)と多段階分化誘導法を併用したマウスiPS細胞の生体内における軟骨分化誘導
  本谷和俊; 小野寺智洋; 寺島理代; 門間太輔; 松岡正剛; 馬場力哉; 上徳善太; 松原新史; 宝満健太郎; 菱村亮介; 岩崎倫政, 第29回日本軟骨代謝学会, 114, 2016年02月
  日本語
• 軟骨細胞の高マンノース型糖鎖の減少は生体内で軟骨変性を惹起する
  宝満健太郎; 小野寺智洋; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 松原新史; 上徳善太; 菱村亮介; 金佑泳; 岩崎倫政, 第29回日本軟骨代謝学会, 109, 2016年02月
  日本語
• 野球選手における肘内側側副靱帯損傷および靱帯再建術が肘関節応力分布に与える影響
  門間太輔; 船越忠直; 古島弘三; 遠藤香織; 但野茂; 藤崎和弘; 伊藤恵康; 岩崎倫政, 日本肘関節学会雑誌, 23, 1, S26, 2016年01月05日
  日本語
• 高純度アルギン酸ゲルと多段階分化誘導法を併用したマウスiPS細胞軟骨分化誘導
  本谷和俊; 小野寺智洋; 寺島理代; 門間太輔; 松岡正剛; 馬場力哉; 上徳善太; 松原新史; 宝満健太郎; 菱村亮介; 金佑泳; 岩崎倫政, 北海道整形災害外科学会雑誌, 58, suppl-2, 27, 2016年
  日本語
• In vivoにおける高純度アルギン酸ゲルと多段階分化誘導法を併用したマウスiPS細胞軟骨分化誘導
  本谷和俊; 小野寺智洋; 寺島理代; 門間太輔; 松岡正剛; 馬場力哉; 上徳善太; 松原新史; 宝満健太郎; 菱村亮介; 岩崎倫政, 日本整形外科学会雑誌, 90, 8, S1486, 2016年
  日本語
• 骨軟骨修復に関連するケモカインの網羅的解析
  上徳善太; 小野寺智洋; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 松原新史; 宝満健太郎; 岩崎倫政, 北海道整形災害外科学会雑誌, 58, suppl-2, 26, 2016年
  日本語
• 投球動作が与える肩甲上腕関節の前方不安定性および後方拘縮―CT osteoabsorptiometry法を用いて―
  門間太輔; 船越忠直; 遠藤香織; 瓜田淳; 河村太介; 松井雄一郎; 亀田裕亮; 大泉尚美; 但野茂; 藤崎和弘; 岩崎倫政, 日本整形外科学会雑誌, 89, 8, S1650, 2015年09月10日
  日本語
• 高純度アルギン酸ゲルを併用した骨髄刺激法の効果 家兎骨軟骨欠損モデルを用いて
  馬場 力哉; 小野寺 智洋; 門間 太輔; 松岡 正剛; 本谷 和俊; 遠藤 香織; 東藤 正浩; 但野 茂; 岩崎 倫政, 日本整形外科学会雑誌, 89, 8, S1592, S1592, 2015年09月
  (公社)日本整形外科学会, 日本語
• 野球選手における肘内側側副靭帯損傷および靭帯再建術が肘関節応力分布に与える影響
  門間太輔; 船越忠直; 古島弘三; 遠藤香織; 但野茂; 藤崎和弘; 大泉尚美; 岩崎倫政, 北海道整形災害外科学会, 129th, 28, 2015年
  日本語
• 高純度アルギン酸ゲルと多段階分化誘導法を併用したマウスiPS細胞軟骨分化誘導法の確立
  本谷和俊; 小野寺智洋; 寺島理代; 門間太輔; 松岡正剛; 馬場力哉; 上徳善太; 松原新史; 宝満健太郎; 岩崎倫政, 日本整形外科学会雑誌, 89, 8, S1730, 2015年
• ガングリオシド欠損は軟骨の肥大化を抑制することにより関節軟骨修復を促進する
  松岡正剛; 小野寺智洋; 笹沢史生; 門間太輔; 馬場力哉; 本谷和俊; 上徳善太; 松原新史; 宝満健太郎; 岩崎倫政, 日本整形外科学会雑誌, 89, 8, S1710, 2015年
  日本語
• 軟骨細胞上の高マンノース型糖鎖構造の減少は軟骨変性を促進する
  宝満健太郎; 小野寺智洋; 門間太輔; 松岡正剛; 馬場力哉; 本谷和俊; 松原新史; 上徳善太; 岩崎倫政, 日本整形外科学会雑誌, 89, 8, S1533, 2015年
  日本語
• Long-term stress distribution patterns across the elbow joint in baseball players assessed by computed tomography osteoabsorptiometry (vol 39, pg 336, 2011)
  D. Momma; N. Iwasaki; N. Oizumi; H. Nakatsuchi; T. Funakoshi; T. Kamishima; S. Tadano; A. Minami, AMERICAN JOURNAL OF SPORTS MEDICINE, 40, 1, NP4, NP4, 2012年01月
  英語, その他

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