研究者基本情報

• Ph.D. in Physics and Chemistry of Materials, Sorbonne University, Paris, 2019年09月
• Master 2 in Chemistry of Materials, Sorbonne University, Paris, 2016年09月
• French Engineering Diploma in Urban Engineering, Ecole des Ingénieurs de la Ville de Paris (EIVP Grad School), Paris, 2015年09月

• https://researchmap.jp/lama

• https://orcid.org/0000-0001-8373-6336
• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202301019294984977

• 70985051

• https://orcid.org/0000-0001-8373-6336

• 202301019294984977

• soft matter, hydrogels, self-assembly, photonics, biomimetism, mechanical properties

• ライフサイエンス, 生体材料学, Biomimetic collagen materials, biomineralization
• 自然科学一般, 生物物理、化学物理、ソフトマターの物理, Physics and Chemistry of Materials

研究活動情報

• 2020年04月, 日本学術振興会, 外国人特別研究員 一般 (24ヶ月)
• 2019年12月, Société Chimique de France (French Society of Chemistry), PhD Thesis Prize in Chemistry of Materials
• 2018年12月, Doctoral School Physics and Chemistry of Materials (Sorbonne University), Best oral presentation

• Porous and Tough Polyacrylamide/Carboxymethyl Cellulose Gels Chemically Crosslinked via Cryo-UV Polymerization for Sustained Drug Release
  Duangkamon Viboonratanasri; Daniel Rudolf King; Tsuyoshi Okumura; Mohamad Alaa Terkawi; Yoshinori Katsuyama; Milena Lama; Tomoki Yasui; Takayuki Kurokawa
  Gels, 11, 6, 453, 453, MDPI AG, 2025年06月13日, ［査読有り］
  研究論文（学術雑誌）, While carboxymethyl cellulose (CMC)—a biocompatible and water-soluble cellulose derivative—holds promise for biomedical applications, challenges remain in synthesizing CMC-based hydrogels with covalent crosslinking through free radical polymerization without requiring complex, multi-step processes. In this study, we introduce a facile one-pot strategy that combines CMC with acrylamide (AAm) under cryogelation and low-intensity UV irradiation to achieve covalent bonding and a high polymerization yield. The resulting polyacrylamide/carboxymethyl cellulose (PAAm/CMC) porous gels were systematically evaluated for their chemical, physical, thermal, and drug-release properties, with a focus on the effects of AAm concentration and polymerization temperature (frozen vs. room temperature). Notably, the cryogel synthesized with 2.5 M AAm (PC2.5) exhibited significantly enhanced mechanical properties—that is, an 8.4-fold increase in tensile modulus and a 26-fold increase in toughness—compared with the non-cryo gel. Moreover, PC2.5 demonstrated excellent cyclic compression stability in water and phosphate-buffered saline (PBS), with less than 10% reduction in modulus after 100 cycles. These increases in the mechanical properties of PC2.5 are attributed to the formation of macropores with high polymer density and high crosslinking density at the pore walls. PC2.5 also showed slower drug release in PBS and good cytocompatibility. This study presents a simplified and efficient route for fabricating mechanically robust, covalently crosslinked PAAm/CMC cryogels, highlighting their strong potential for biomedical applications in drug delivery systems.
• Hierarchical Collagen/Apatite Co-assembly for Injection of Mineralized Fibrillar Tissue Analogues
  Milena Lama; Marion Merle; Elora Besso; Camila Bussola Tovani; Guillaume Lauren; Nicole Bouland; Halima Kerdjoudj; Thierry Azaïs; Guylaine Ducoure; Tissiana Bortolotto; Nadine Nassif
  ACS Biomaterials Science & Engineering, 2025年01月13日, ［査読有り］, ［筆頭著者］
  研究論文（学術雑誌）
• Soft hydrogel-embedded ceramic skeleton mimicking bone structure via sacrificial bond concept
  Sukamto; Milena Lama; Jian Ping Gong; Takayuki Nonoyama
  Soft Matter, 2025年, ［査読有り］
  英語, 研究論文（学術雑誌）, Bone, consisting of calcium phosphate minerals, rigid collagen fibrils, and acidic proteins, exhibits stiff and tough mechanical properties. On a molecular scale, covalent cross-linking in proteins, ionic interactions within proteins...
• Fatigue Behaviors of Anisotropic Hydrogels with a Macroscopic Lamellar Bilayer Structure and Swelling Effects
  Most Laboni Begum; Milena Lama; Wenqi Yang; Xiang Li; Md. Anamul Haque; Xueyu Li; Jian Ping Gong
  Macromolecules, American Chemical Society (ACS), 2024年11月26日, ［査読有り］
  研究論文（学術雑誌）
• Structural Color Materials with Color Mixing Effect Using Noble Metal‐Free Plasmonic Particles in SiO2–ZrN System
  Shinji Noguchi; Milena Lama; Yuta Fujii; Akira Miura; Kiyoharu Tadanaga
  Advanced Optical Materials, 2024年07月, ［査読有り］
  研究論文（学術雑誌）
• Mechanical Reinforcement of Lamellar Bilayer Hydrogels by Small Amounts of Co-surfactants
  Milena Lama; Jian Ping Gong
  ACS Omega, 2023年07月03日, ［査読有り］, ［筆頭著者］
  研究論文（学術雑誌）
• Biomimetic Tough Gels with Weak Bonds Unravel the Role of Collagen from Fibril to Suprafibrillar Self‐Assembly
  Milena Lama; Biravena Raveendranathan; Julie Brun; Francisco M. Fernandes; Cédric Boissière; Nadine Nassif; Alba Marcellan
  Macromolecular Bioscience, 21, 6, 2000435, 2000435, Wiley, 2021年04月21日, ［査読有り］, ［筆頭著者］
  研究論文（学術雑誌）
• Origin of transparency in scattering biomimetic collagen materials
  Chrystelle Salameh; Flore Salviat; Elora Bessot; Miléna Lama; Jean-Marie Chassot; Elodie Moulongui; Yan Wang; Marc Robin; Arnaud Bardouil; Mohamed Selmane; Franck Artzner; Alba Marcellan; Clément Sanchez; Marie-Madeleine Giraud-Guille; Marco Faustini; Rémi Carminati; Nadine Nassif
  Proceedings of the National Academy of Sciences, 117, 22, 11947, 11953, Proceedings of the National Academy of Sciences, 2020年05月18日, ［査読有り］
  研究論文（学術雑誌）, Significance
  
  Disordered materials with heterogeneities at scales ranging from nano- to micrometers usually scatter visible light and become opaque beyond a certain thickness. However, transparent materials are found in nature. The physical origin of transparency in natural and artificial biopolymer materials is still not fully understood. Here, a gap of transparency is found in synthetic fibrillar collagen matrices within a very narrow range of concentration. The transparency results from structural partial order inhibiting light scattering, while preserving mechanical stability, stiffness, and nonlinearity. The potential to produce biomimetic hydrogels with such striking optical properties by self-assembly opens an interesting route in the study of photonic materials and provides new elements in the understanding of the appearance of transparency in natural materials.
• Self‐Assembled Collagen Microparticles by Aerosol as a Versatile Platform for Injectable Anisotropic Materials
  Milena Lama; Francisco M. Fernandes; Alba Marcellan; Juliette Peltzer; Marina Trouillas; Sébastien Banzet; Marion Grosbot; Clément Sanchez; Marie‐Madeleine Giraud‐Guille; Jean‐Jacques Lataillade; Bernard Coulomb; Cédric Boissière; Nadine Nassif
  Small, 16, 4, 1902224, 1902224, Wiley, 2019年12月27日, ［査読有り］, ［筆頭著者］
  研究論文（学術雑誌）
• Structure-properties relationship in dense collagen gels produced by injection of spray-dried collagen
  Milena Lama
  2019年09月16日, ［査読有り］, ［筆頭著者］
  英語, 学位論文（博士）, Injection of dense collagen to obtain 3D biomimetic scaffolds in terms of structure and mechanical properties is challenging for regenerative medicine since it would avoid open-surgery. It is well-known that highly concentrated collagen solutions can form liquid crystal mesophases with tissue-like geometries. Thus, it is possible to obtain 3D collagen gels in vitro with better mechanical properties, without widely used chemical crosslinkers that may lead to inflammatory responses. Nevertheless, the injection of highly concentrated collagen solutions is unlikely due to their high viscosity.How to combine biomimetism and injectability of dense collagen gels?To achieve this goal we concentrate acidic collagen solutions by spray-drying, forming dense collagen beads. A simple weighing of the beads determines the concentration of the gels. Mixed with an aqueous solvent, the beads are injected into a mold mimicking a tissue defect. The fibrillogenesis in vitro is induced within the collagen solutions that transform into stiff gels. Electron and polarized light microscopies show organizations resulting from collagen self-assembly at macroscopic length scale depending on the collagen concentration i.e. from 3wt% to 8wt%. Mechanical tests results reveal tissue-like properties strongly linked to collagen fibrils ultrastructure. This study opens perspectives in tissue repair in setting the framework of a library made of biomimetic (anisotropic, dense and stiff) and injectable collagen gels, enabling minimally invasive procedures.

• Mechanical reinforcement of self-assembled photonic hydrogels by small amounts of co-surfactants
  Milena Lama; Jian Ping Gong
  SPSJ 34th Annual Meeting of Research Group on Polymer Gels (Tokyo, Japan), 2023年01月19日, 英語, 口頭発表（一般）
• Mechanical reinforcement of lamellar bilayer hydrogels by small amounts of co-surfactants
  Milena Lama; Jian Ping Gong
  10th Conference on Exploring Next-Generation Materials Science and Nanoscience & Workshop on Soft and Nano Materials (Sapporo, Japan), 2023年01月08日, 英語, 口頭発表（一般）
• Role of co-surfactants on improving the mechanical response of lamellar photonic hydrogels
  Milena Lama; Jian Ping Gong
  SPSJ 71st Fall Meeting (Sapporo, Japan), 2022年09月05日, 英語, 口頭発表（一般）
• Modification of the mechanical response of self-assembled photonic hydrogels by small amounts of co-surfactants
  Milena Lama; Jian Ping Gong
  SPSJ 37th Summer University in Hokkaido (Sapporo, Japan), 2022年08月15日, 英語, ポスター発表
• Modification of the mechanical response of self-assembled photonic hydrogels by small amounts of co-surfactants
  Milena Lama; Jian Ping Gong
  Soft Matter Summer School (Cargese, France), 2022年07月16日, 英語, ポスター発表
• Mechanical properties of biomimetic hydrogels produced by injection of spray-dried collagen
  Milena Lama; Francisco M. Fernandes; Cedric Boissiere; Alba Marcellan; Nadine Nassif
  Multifunctional, Hybrid and Nanomaterials (Sitges, Spain), 2019年03月12日, 英語, 口頭発表（一般）
• Mechanical properties of tissue-like hydrogels produced by injection of spray-dried collagen
  Milena Lama; Francisco M. Fernandes; Cedric Boissiere; Nadine Nassif; Alba Marcellan
  Doctoral School Days (Paris, France), 2018年12月13日, 英語, 口頭発表（一般）
• From collagen self-assembly to biomimetic materials: Applications in biomineralization and tissue engineering
  Milena Lama; replacing Nadine Nassif
  Design of Soft Green Materials (workshop at MIT) (Cambridge, MA, USA), 2018年11月15日, 英語, 口頭発表（招待・特別）
  ［招待講演］
• Mechanical properties of tissue-like hydrogels produced by injection of spray-dried collagen
  Milena Lama; Francisco M. Fernandes; Cedric Boissiere; Nadine Nassif; Alba Marcellan
  Polymer Networks & Gels (Praha, Czech Republic), 2018年06月18日, 英語, 口頭発表（一般）
• Mechanical properties of dense collagen scaffolds produced by injection of spray-dried collagen in suspension
  Milena Lama; Francisco M. Fernandes; Cedric Boissiere; Alba Marcellan; Nadine Nassif
  Collagen in all its forms (Lyon, France), 2017年11月09日, 英語, 口頭発表（一般）
• Spray-dried collagen for injecting dense collagen scaffolds with tunable mechanical properties
  Milena Lama; Francisco M. Fernandes; Cedric Boissiere; Nadine Nassif; Alba Marcellan
  Soft Matter Days (Gif-sur-Yvette, France), 2017年06月26日, 英語, ポスター発表

• Elucidation of polyurethane degradation via high-throughput experimentation and X-ray scattering
  2026年04月 - 2027年03月
  Milena Lama; Melody M. Morris
  Hokkaido University, University of Massachussets Amherst, 研究代表者
• 非イオン性界面活性剤の六方相により得られたフォトニックヒドロゲルの構造と特性
  科学研究費助成事業
  2021年01月 - 2023年03月
  LAMA Milena
  日本学術振興会, 特別研究員奨励費, 北海道大学, 研究代表者, 21F20769

• ポリウレタン複合体、ポリウレタン複合体の製造方法、および、原料キット
  特許権, ラマ ミレナ; 中島 祐; グン チェンピン; 松本 友孝; 景岡 正和; 中野 隆志, 三井化学, 北海道大学
  特願2025-173829, 2025年10月15日
• ポリマー複合体、ポリマー複合体の製造方法、および、原料キット
  特許権, 松本 友孝; 景岡 正和; 中野 隆志; ラマ ミレナ; 中島 祐; グン チェンピン, 三井化学, 北海道大学
  特願2025-173824, 2025年10月15日
• Compositions for use as dentine substitute
  特許権, Tissiana Bortolotto; I. Krejci; Nadine Nassif; Milena Lama; Camila Bussola Tovani
  2023年09月28日
  WO 2023180479A1, 2022年03月23日
• Compositions for mineralized tissues repair and regeneration
  特許権, Nadine Nassif; Milena Lama; Camila Bussola Tovani; Marc Robin, Sorbonne Université
  2023年09月28日
  WO 2023180783A1, 2022年03月23日