研究者基本情報

• 博士（医学）, 北海道大学

• https://researchmap.jp/nomy

• 201701010153236816

• 大学生
• 社交不安症
• 摂食障害
• 性格特性
• 気質
• パーソナリティ
• 自殺予防
• 気分障害

• ライフサイエンス, 精神神経科学, 摂食症、社交不安症、うつ病、自殺予防
• 人文・社会, 臨床心理学, パーソナリティ、自尊感情、セルフコンパッション

• 修士課程, 医学院
• 博士課程, 医学院

研究活動情報

• 2025年05月, Neuropsychopharmacology Reports, NPPR レビュー賞
  Antidepressants for social anxiety disorder: A systematic review and meta-analysis

• Enhancing self-esteem and self-compassion to mitigate suicide risk: A feasibility and acceptability study among Japanese university students.
  Nguyen Tan Dat; Nobuyuki Mitsui; Satoshi Asakura; Yuki Kako; Keisuke Takanobu; Yutaka Fujii; Ichiro Kusumi
  Asian journal of psychiatry, 101, 104207, 104207, 2024年08月30日, ［国際誌］
  英語, 研究論文（学術雑誌）, OBJECTIVES: Suicide is a serious mental health problem among university students. The current study aimed to examine the effectiveness of a novel intervention that targets suicide risk by enhancing self-esteem and self-compassion. METHODS: Participants were recruited from the healthcare center at a Japanese University. Measurements of suicidal risk, self-compassion, self-esteem, and other psychological variables were collected at baseline, post-intervention, four-week follow-up, eight-week follow-up, and twelve-week follow-up. Participants also provided feedback on the program's acceptability. RESULTS: A total of 17 participants consented to participate in the intervention, 14 completed post-treatment assessment, 10 completed the four-week follow-up assessment, and 8 completed the eight-week and twelve-week follow-up assessment. Following the intervention, the study observed moderate to large improvements in self-esteem, self-compassion, hopelessness, depression, and suicide risk. The participants also reported reliable changes in clinical outcomes and positive perceptions of the program. CONCLUSIONS: The psychoeducation program exhibited high acceptability and feasibility and promising early outcomes. Despite the small sample size and lack of a control group, these findings suggest potential benefits of the program. Further studies for examining the efficacy of the program are highly warranted.
• 非自殺的な自傷行為(NSSI)と自殺行動障害(SBD)の初診時リスクファクターについて
  澤山 初音; 三井 信幸; 豊島 邦義; 藤井 泰; 賀古 勇輝; 久住 一郎
  精神神経学雑誌, 125, 12, 1080, 1080, (公社)日本精神神経学会, 2023年12月
  日本語
• 重症遷延性摂食障害から回復に至った一例
  三井 信幸; 賀古 勇輝; 渡辺 晋也; 豊島 邦義; 久住 一郎
  心身医学, 63, 6, 566, 567, (一社)日本心身医学会, 2023年11月
  日本語
• 神経性やせ症に先天性プロテインS欠損症が合併した1例
  菱山 真広; 三井 信幸; 渡辺 晋也; 豊島 邦義; 賀古 勇輝; 久住 一郎; 杉田 純一
  心身医学, 63, 6, 567, 567, (一社)日本心身医学会, 2023年11月
  日本語
• クロザピン誘発発作に対する抗痙攣薬の使用 統合失調症患者における後ろ向き研究(Use of Anti-Seizure Medications for Clozapine-Induced Seizures: A Retrospective Study in Patients with Schizophrenia)
  堀之内 徹; 中村 悠一; 石川 修平; 橋本 直樹; 成田 尚; 三井 信幸; 賀古 勇輝; 久住 一郎
  てんかん研究, 41, 2, 319, 319, (一社)日本てんかん学会, 2023年09月
  英語
• Japanese Society of Anxiety and Related Disorders/Japanese Society of Neuropsychopharmacology: Clinical Practice Guideline for Social Anxiety Disorder (2021)
  Satoshi Asakura; Naoki Yoshinaga; Hisashi Yamada; Yutaka Fujii; Nobuyuki Mitsui; Yoshihiro Kanai; Takeshi Inoue; Eiji Shimizu
  Neuropsychopharmacology Reports, 43, 3, 288, 309, 2023年09月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, The development of clinical practice guidelines for social anxiety disorder began in March 2018 when the Joint Clinical Practice Guideline Development Committee for Anxiety and Obsessive-Compulsive Disorders was formed by the Japanese Society of Anxiety and Related Disorders and Japanese Society of Neuropsychopharmacology to jointly develop guidelines for anxiety and obsessive-compulsive disorders. Based on the universal concept of evidence-based medicine, three clinical questions (CQs) about pharmacotherapy and psychotherapy were developed for clinical guidelines for social anxiety disorder, panic disorders, and obsessive-compulsive disorder in accordance with the Minds "Manual for Guidelines Development 2017 by the Japan Council for Quality Health Care: CQ1-"What is the recommended pharmacotherapy for social anxiety disorder in adults?"; CQ2-"What is the recommended psychotherapy (psychological intervention) for social anxiety disorder in adults?"; and CQ3-"What are the recommendations regarding monotherapy and combination therapy for social anxiety disorder in adults in terms of pharmacotherapy and psychotherapy (psychological interventions)?" Summarized recommendations for social anxiety disorder in adults are selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitor for CQ1, cognitive behavioral therapy for CQ2, and there are no recommendations regarding monotherapy and combination therapy for CQ3. These were answered by considering the balance between benefits and harms based on systematic reviews of each. The aim of this brief guideline for the standard-of-care (i.e., medical treatment) for social anxiety disorder in adults (18 years and older) was to help "shared decision making," in which medical professionals, including physicians, and patients share scientific evidence to decide on a course of treatment.
• 医療観察法指定入院医療機関の未整備が地域に及ぼす影響
  賀古 勇輝; 直江 亮; 高信 径介; 三井 信幸; 久住 一郎
  日本社会精神医学会雑誌, 32, 3, 259, 260, (一社)日本社会精神医学会, 2023年08月
  日本語
• 神経性やせ症に対するCVポートを用いた治療の有効性に関する検討
  小川 鴻基; 三井 信幸; 黒鳥 偉作; 豊島 邦義; 藤井 泰; 賀古 勇輝; 久住 一郎
  精神神経学雑誌, 2023特別号, S576, S576, (公社)日本精神神経学会, 2023年06月
  日本語
• Relationship between self-esteem and suicidal ideation before and during COVID-19 in a non-clinical sample: mediating effects of psychological distress and hopelessness.
  Nguyen Tan Dat; Nobuyuki Mitsui; Satoshi Asakura; Yutaka Fujii; Kuniyoshi Toyoshima; Ichiro Kusumi
  Frontiers in psychiatry, 14, 1240715, 1240715, 2023年, ［国際誌］
  英語, 研究論文（学術雑誌）, INTRODUCTION: Several studies have highlighted the impact of the novel coronavirus disease (COVID-19) pandemic on suicide. Accordingly, investigating the risk factors of suicide during this crisis is important. Based on the escape theory of suicide, the current study examined the serial mediating roles of psychological distress and hopelessness in the relationship between self-esteem and suicidal ideation. It also aimed to explore whether or not the COVID-19 pandemic changed the mediation effect in any way. METHODS: Data were collected from 645 university students before and during the pandemic. The study employed mediation and multi-group analyses to test the hypotheses. RESULTS: The results demonstrated that individuals with low self-esteem reported high psychological distress, which further lead to hopelessness and eventually heightened suicidal ideation. Multi-group analysis revealed that psychological distress exerted a greater impact on suicidal ideation during COVID-19. DISCUSSION: The finding suggested that self-esteem, hopelessness, and psychological distress could help elucidate the development of suicidal ideation. Clinicians may target these factors in suicide prevention programs, particularly in the settings of the COVID-19 pandemic or future crisis.
• Comparison of convinced subtype of Taijin-kyofu and schizophrenia on cognitive assessments of Japanese patients.
  Yutaka Fujii; Satoshi Asakura; Nguyen Tan Dat; Keisuke Takanobu; Shinya Watanabe; Kuniyoshi Toyoshima; Nobuyuki Mitsui; Atsuhito Toyomaki; Naoki Hashimoto; Yuki Kako; Ichiro Kusumi
  Asian journal of psychiatry, 75, 103215, 103215, 2022年09月, ［国際誌］
  英語
• Antidepressants for social anxiety disorder: A systematic review and meta‐analysis
  Nobuyuki Mitsui; Yutaka Fujii; Satoshi Asakura; Hissei Imai; Hisashi Yamada; Naoki Yoshinaga; Yoshihiro Kanai; Takeshi Inoue; Eiji Shimizu
  Neuropsychopharmacology Reports, 42, 4, 398, 409, Wiley, 2022年07月18日, ［国際誌］
  英語, 研究論文（学術雑誌）, AIM: This systematic review is aimed to update and reintegrate the pharmacotherapy of social anxiety disorder (SAD), including the Japanese medical database. METHODS: We conducted a systematic review and meta-analysis of pharmacotherapy of SAD according to the Medical Information Distribution Service. We used data from a most recent systematic review, and updated search were conducted using MEDLINE, PubMed, CENTRAL, ICTRP, and ICHUSHI from August 1st, 2017 to January 31st, 2022. The outcome were response rates assessed by Clinical Global Impressions Improvement, efficacy assessed by the Liebowitz Social Anxiety Scale (LSAS), and dropout rates. We performed a random effect of meta-analysis to obtain the differences in each outcome between active medication and placebo. We used RevMan version 5.3 for analyses. RESULTS: We identified 5 studies through update search and performed meta-analysis for 33 studies on selective serotonin reuptake inhibitor (SSRI) and 6 studies on serotonin noradrenalin reuptake inhibitor (SNRI). The response rate (RR = 1.62) and the LSAS score reduction (mean difference = -9.65) of SSRI, and the response rate (RR = 1.57) and the LSAS score reduction (mean difference = -11.72) of SNRI were significantly different from placebo. The dropout rates of SSRI or SNRI were not significant. The response rates of SSRIs in both Japanese studies (RR = 1.44) and countries other than Japan (RR = 1.67) were significant. Most findings were based on low quality of evidence. CONCLUSION: SSRIs are valid option for pharmacotherapy of SAD including Japanese patients. SNRIs are another effective option. However, the results should be interpreted cautiously due to several risk of bias.
• COVID-19流行下における自殺関連行動の特徴 当科通院患者を対象とした後方視的研究
  内藤 大; 三井 信幸; 豊島 邦義; 藤井 奏; 賀古 勇輝; 朝倉 聡; 久住 一郎
  精神神経学雑誌, 124, 7, 503, 503, (公社)日本精神神経学会, 2022年07月
  日本語
• 摂食障害の認知機能障害
  宮野 史也; 豊巻 敦人; 高信 径介; 豊島 邦義; 藤井 泰; 三井 信幸; 賀古 勇輝; 朝倉 聡; 久住 一郎
  精神神経学雑誌, 124, 4付録, S, 380, (公社)日本精神神経学会, 2022年04月
  日本語
• The Effectiveness of Self-Esteem-Related Interventions in Reducing Suicidal Behaviors: A Systematic Review and Meta-Analysis.
  Nguyen Tan Dat; Nobuyuki Mitsui; Satoshi Asakura; Keisuke Takanobu; Yutaka Fujii; Kuniyoshi Toyoshima; Yuki Kako; Ichiro Kusumi
  Frontiers in psychiatry, 13, 925423, 925423, 2022年, ［国際誌］
  英語, 研究論文（学術雑誌）, Suicide is a serious social issue and is often treated using psychological interventions. The current systematic review and meta-analysis aimed to investigate the effectiveness of self-esteem-related interventions on suicidal behaviors. A systematic literature search for randomized controlled trials (RCTs) including a self-esteem component was conducted on 29 May 2021 and updated on 4 April 2022. In total, 12 studies were included in the systematic review and five studies were included in the meta-analysis. Small effect sizes were found for suicidal ideation at post intervention [g = -0.24, 95% CI (-0.48, 0.00)] and a 3-month follow-up [g = -0.36, 95% CI (-0.62, -0.11)]. However, these results should be interpreted cautiously due to the limited number of included studies and varied sample population. In conclusion, the current review suggests that future intervention studies should incorporate self-esteem enhancement in the treatment of suicidal behaviors, especially for suicidal ideation. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=250882.
• The mediating role of hopelessness in the relationship between self-esteem, social anxiety, and suicidal ideation among Japanese university students who visited a university health care center
  Nguyen Tan Dat; Nobuyuki Mitsui; Satoshi Asakura; Shinya Watanabe; Keisuke Takanobu; Yutaka Fujii; Kuniyoshi Toyoshima; Yuki Kako; Ichiro Kusumi
  Journal of Affective Disorders Reports, 6, 100192, 100192, Elsevier BV, 2021年12月
  研究論文（学術雑誌）
• 双極性障害の症状寛解期における主観的認知機能と客観的認知機能との関連
  豊島 邦義; 豊巻 敦人; 高信 径介; 渡辺 晋也; 藤井 泰; 三井 信幸; 賀古 勇輝; 朝倉 聡; 久住 一郎
  精神神経学雑誌, 2021特別号, S555, S555, (公社)日本精神神経学会, 2021年09月
  日本語
• 解離性障害の経過中に発生する自殺企図に関する考察
  三井 信幸; 岩渕 賢嗣; 渡辺 晋也; 高信 径介; 豊島 邦義; 藤井 泰; 賀古 勇輝; 久住 一郎
  精神神経学雑誌, 2021特別号, S617, S617, (公社)日本精神神経学会, 2021年09月
  日本語
• Prevalence of depressive symptoms and psychological distress in Japanese university-enrolled students before and during the coronavirus disease 2019 pandemic.
  Yutaka Fujii; Satoshi Asakura; Keisuke Takanobu; Shinya Watanabe; Kuniyoshi Toyoshima; Nobuyuki Mitsui; Yuki Kako; Satoshi Hashino; Ichiro Kusumi
  Psychiatry and clinical neurosciences, 75, 9, 294, 295, 2021年09月, ［国際誌］
  英語
• 刑法39条事件における被害者支援について
  賀古 勇輝; 高信 径介; 渡辺 晋也; 豊島 邦義; 三井 信幸; 藤井 泰; 朝倉 聡; 久住 一郎
  日本社会精神医学会雑誌, 30, 3, 298, 298, (一社)日本社会精神医学会, 2021年08月
  日本語
• 刑法39条事件における被害者支援について
  賀古 勇輝; 高信 径介; 渡辺 晋也; 豊島 邦義; 三井 信幸; 藤井 泰; 朝倉 聡; 久住 一郎
  司法精神医学, 16, 1, 127, 127, 日本司法精神医学会, 2021年08月
  日本語
• 保佐人の同意による医療保護入院における法的問題点
  高信 径介; 菱山 真広; 浅野 孝太朗; 斉藤 かおり; 三井 信幸; 賀古 勇輝; 久住 一郎
  司法精神医学, 16, 1, 129, 129, 日本司法精神医学会, 2021年08月
  日本語
• Pulverizing medication as a harm reduction and intentional drug overdose prevention strategy: Two case studies.
  Keisuke Takanobu; Daisuke Okazaki; Shinya Watanabe; Nobuyuki Mitsui; Teruaki Tanaka
  Neuropsychopharmacology reports, 41, 3, 430, 433, 2021年06月24日, ［国際誌］
  英語, 研究論文（学術雑誌）, AIMS: We explored the use of pulverized medication as a new method to prevent intentional drug overdose. METHODS: This case study presents data obtained from the medical records of two female patients, aged 19 and 27 years, who presented with schizophrenia and neurodevelopmental disorder, respectively. Both patients provided written informed consent. Medication was administered to the two patients in powdered form, as opposed to in tablet form, in an attempt to prevent intentional drug overdose. RESULTS: This administration method successfully prevented intentional drug overdose for 3 and 5 years in each case, respectively. However, case-control or prospective cohort studies are needed to rule out biases, including cognitive bias. CONCLUSION: Pulverizing medication is a simple and effective means of preventing intentional drug overdose by restricting access to the means of suicide, regardless of the type of mental disorder.
• 銅欠乏により汎血球減少をきたした摂食障害の1例
  岩渕 賢嗣; 藤井 泰; 渡辺 晋也; 豊島 邦義; 三井 信幸; 賀古 勇輝; 久住 一郎
  精神神経学雑誌, 123, 5, 296, 296, (公社)日本精神神経学会, 2021年05月
  日本語
• Effectiveness of suicide prevention gatekeeper training for university teachers in Japan
  Naoki Hashimoto; Hiroko Takeda; Yutaka Fujii; Yuriko Suzuki; Takahiro A. Kato; Daisuke Fujisawa; Kumi Aoyama-Uehara; Kotaro Otsuka; Nobuyuki Mitsui; Satoshi Asakura; Ichiro Kusumi
  Asian Journal of Psychiatry, 60, 102661, 102661, Elsevier BV, 2021年04月, ［国際誌］
  英語, 研究論文（学術雑誌）, Suicide is a leading cause of death among Japanese college and university students. Our previous study showed that the gatekeeper training (GKT) program significantly improved competence and confidence in the management of suicidal students in university administrative staff. However, we could not determine which component of the program was effective, nor if this program was effective for university teachers as well. In the current study, 81 university teachers were recruited; 63 of them received a general mental health lecture (MHL) and 18 of them received a 2.5 -h GKT program based on the Mental Health First Aid program. Competence and confidence in managing suicide intervention and behavioral intention as a gatekeeper were assessed by a self-report questionnaire before and immediately after the intervention. As a result, we found a significant improvement in competence in the management of suicidal students in the GKT group compared to the MHL group. We also found significant improvements in confidence in the management of suicidal students and behavioral intention as gatekeepers in the GKT group, although the questionnaires for these outcomes were not validated. The program satisfaction score was significantly higher in the GKT group than in the MHL group. To our knowledge, this is the first study to evaluate a GKT program for university teachers in Japan. By comparing the two groups, we explicitly confirmed that active involvement of the participants is crucial for effective suicide prevention training.
• Predictors of social anxiety disorder with major depressive episodes among Japanese university students.
  Shinya Watanabe; Nobuyuki Mitsui; Satoshi Asakura; Kuniyoshi Toyoshima; Keisuke Takanobu; Yutaka Fujii; Yuki Kako; Ichiro Kusumi
  PloS one, 16, 9, e0257793, 2021年, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Social anxiety disorder (SAD) develops in the early teens and is a common disorder among university students. Understanding the predictive factors of SAD comorbid with major depressive episode (MDE) is important for student mental health care. The aim of this study was to identify the personality traits that predict SAD with MDE by analyzing longitudinal data of Japanese university students. METHODS: In this retrospective study, Japanese university students who visited the health care center of Hokkaido University for the first time were divided into the following four groups: "Control" (n = 43), "MDE" (n = 16), "SAD" (n = 28), and "SAD with MDE" (n = 61) based on the Patient Health Questionnaire-9 (PHQ-9), the Liebowitz Social Anxiety Scale, and core anxiety symptoms for SAD in the Mini International Neuropsychiatric Interview during screening. Predictors for SAD with MDE were identified by a four-group comparison of the Temperament and Character Inventory and PHQ-9 data previously obtained at the enrollment using analysis of variance and post-hoc tests. RESULTS: Upon comparing the four groups using analysis of variance, there were significant differences in the baseline PHQ-9 summary score, Harm-Avoidance (HA), and Self-Directedness (SD). According to results of the post-hoc test, all three showed a significant difference between the "Control" and "SAD with MDE." Furthermore, there was a significant difference in HA scores between "SAD" and "Control." In all the groups, the mean time from enrollment to the first visit to the center was >2 years. CONCLUSION: A higher HA score at baseline is a predictor of SAD with or without MDE. Higher PHQ-9 summary and lower SD scores at baseline are predictive factors of SAD with MDE.
• Character configuration, major depressive episodes, and suicide-related ideation among Japanese undergraduates.
  Keisuke Takanobu; Nobuyuki Mitsui; Shinya Watanabe; Kuniyoshi Toyoshima; Yutaka Fujii; Yuki Kako; Satoshi Asakura; Ichiro Kusumi
  PloS one, 16, 5, e0251503, 2021年, ［国際誌］
  英語, 研究論文（学術雑誌）, AIM: To enable early identification of university students at high risk for suicide, we examined personality as a predictive factor for major depressive episodes and suicide-related ideation. METHODS: From 2011 to 2013, we administered the Patient Health Questionnaire-9 (PHQ-9) and the Temperament and Character Inventory (TCI) to 1,997 university students at enrollment (T1). We previously conducted a study using the same data set; this is a re-analysis of the dataset. To prevent contamination of data, participants diagnosed with a depressive episode were excluded at T1. Three years after enrollment (T2), we re-administered the PHQ-9 to the same students. We statistically compared TCI scores at T1 among depressive episode groups and suicide-related ideation groups. Two-way ANOVA and Cochran-Armitage trend tests were used to analyze the relationships between personality traits, depressive episodes, and suicide-related ideation. RESULTS: The PHQ-9 summary scores at baseline (T1) were 3.0 (±2.7), with female students scoring 4.6 (±2.9) and male students 2.9 (±2.6, p = 0.025). The major depressive episode group at T2 had lower self-directedness (SD) scores at T1 than the non-depressive episode control group. The suicide-related ideation (SI) group at T2 also had higher harm avoidance (HA), lower SD, and lower cooperativeness (C) scores than the non-SI group at T1. The Cochran-Armitage trend tests revealed significant associations between character configurations composed of SD and C, and both depressive episodes at T2 and SI at T2. CONCLUSION: The temperament feature of high HA at baseline and character configurations of low SD and low C at baseline are the most contributory predictors for the novel development of depressive episodes and SI among Japanese university students.
• Personality traits mediate the association between perceived parental bonding and well-being in adult volunteers from the community
  Akiko Murakoshi; Nobuyuki Mitsui; Jiro Masuya; Yota Fujimura; Shinji Higashi; Ichiro Kusumi; Takeshi Inoue
  BioPsychoSocial Medicine, 14, 1, 28, 28, Springer Science and Business Media LLC, 2020年12月, ［国際誌］
  英語, 研究論文（学術雑誌）,
  
  
  Previous studies reported that subjective well-being in adulthood correlates with perceived parental bonding in childhood as well as personality traits. However, whether personality traits mediate the effect of perceived parental bonding on well-being or not has not been reported to date. In this study, we hypothesized that ‘parental care and overprotection’ in childhood affect ‘well-being’ in adulthood through various ‘personality traits’, and analyzed this using structural equation modeling.
  
  
  
  
  
  A total of 402 adult volunteers from the community provided responses to the following questionnaires: 1) Parental Bonding Instrument, 2) Temperament and Character Inventory, and 3) The Subjective Well-being Inventory. Two structural equation models were designed and the maximum likelihood estimation method was used for covariance structure analysis.
  
  
  
  
  
  Parental care in childhood directly increased well-being in adulthood and indirectly increased it through personality traits (harm avoidance, reward dependence, and self-directedness). Parental overprotection in childhood had no direct effect on well-being in adulthood but decreased well-being in adulthood indirectly through personality traits (harm avoidance, reward dependence, and self-directedness) and increased it through one personality trait (self-transcendence).
  
  
  
  
  
  This study showed that the influences of perceived parental bonding on well-being in adulthood are mediated by self-directedness, harm avoidance, reward dependence, and self-transcendence among the seven personality dimensions evaluated by the Temperament and Character Inventory.
  
  
  
• 双極性障害の症状寛解期における主観的認知機能、服薬、および服薬の効果の自覚
  豊島 邦義; 豊巻 敦人; 高信 径介; 渡辺 晋也; 藤井 泰; 三井 信幸; 賀古 勇輝; 朝倉 聡; 久住 一郎
  総合病院精神医学, 32, Suppl., S, 159, (一社)日本総合病院精神医学会, 2020年11月
  日本語
• 半夏厚朴湯が心理的葛藤の処理に寄与したうつ病の一例
  豊島 邦義; 高信 径介; 渡辺 晋也; 藤井 泰; 三井 信幸; 賀古 勇輝; 朝倉 聡; 久住 一郎
  総合病院精神医学, 32, Suppl., S, 159, (一社)日本総合病院精神医学会, 2020年11月
  日本語
• 双極性障害の症状寛解期における主観的認知機能と社会機能との関連について
  豊島 邦義; 豊巻 敦人; 高信 径介; 渡辺 晋也; 三井 信幸; 賀古 勇輝; 朝倉 聡; 久住 一郎
  精神神経学雑誌, 2020特別号, S290, S290, (公社)日本精神神経学会, 2020年09月
  日本語
• 不安症・強迫症の診療ガイドライン 社交不安症の診療ガイドライン
  朝倉 聡; 山田 恒; 藤井 泰; 三井 信幸; 吉永 尚紀; 金井 嘉宏
  精神神経学雑誌, 2020特別号, S363, S363, (公社)日本精神神経学会, 2020年09月
  日本語
• 双極性障害の症状寛解期における主観的認知機能とQOLに関する検討
  豊島 邦義; 豊巻 敦人; 高信 径介; 渡辺 晋也; 藤井 泰; 三井 信幸; 賀古 勇輝; 朝倉 聡; 久住 一郎
  日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集, 50回・42回・4回, 196, 196, 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会, 2020年08月
  日本語
• 双極性障害の症状寛解期における主観的認知機能と病識に関する検討
  豊島 邦義; 豊巻 敦人; 高信 径介; 渡辺 晋也; 藤井 泰; 三井 信幸; 賀古 勇輝; 朝倉 聡; 久住 一郎
  日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集, 50回・42回・4回, 205, 205, 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会, 2020年08月
  日本語
• 双極性障害の症状寛解期における主観的認知機能と事象関連電位に関する検討
  豊島 邦義; 宮崎 茜; 豊巻 敦人; 高信 径介; 渡辺 晋也; 藤井 泰; 三井 信幸; 賀古 勇輝; 朝倉 聡; 久住 一郎
  日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集, 50回・42回・4回, 213, 213, 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会, 2020年08月
  日本語
• 神経性やせ症に先天性プロテインS欠損症が合併した1例
  菱山 真広; 三井 信幸; 渡辺 晋也; 豊島 邦義; 賀古 勇輝; 久住 一郎; 杉田 純一
  精神神経学雑誌, 122, 5, 394, 394, (公社)日本精神神経学会, 2020年05月
  日本語
• 学童期に低身長・低体重で発症した出産恐怖の1例
  小野 鉄舟; 三井 信幸; 渡辺 晋也; 豊島 邦義; 賀古 勇輝; 久住 一郎
  精神神経学雑誌, 122, 5, 395, 395, (公社)日本精神神経学会, 2020年05月
  日本語
• 北海道における触法精神障害者医療の現状と展望
  高信 径介; 三井 信幸; 賀古 勇輝; 久住 一郎
  司法精神医学, 15, 1, 89, 89, 日本司法精神医学会, 2020年03月
  日本語
• 長期間にわたる全生活史健忘からの自然回復 右内側側頭葉の血流回復が確認された1例
  三井 信幸; 大柳 有加; 賀古 勇輝; 久住 一郎
  精神神経学雑誌, 122, 2, 168, 168, (公社)日本精神神経学会, 2020年02月
  日本語
• Natural recovery from long-lasting generalised dissociative amnesia and of cerebral blood flow.
  Nobuyuki Mitsui; Yuka Oyanagi; Yuki Kako; Ichiro Kusumi
  BMJ case reports, 12, 12, 2019年12月11日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, A 40-year-old man presented with generalised dissociative amnesia. At 2 weeks after onset, N-isopropyl-[123I] p-iodoamphetamine-single-photon emission CT imaging of the brain revealed hypoperfusion in the right medial temporal area. Organic brain damage was ruled out. His inability to recall information was attributed to psychological stress related to his employment. Consistent with this diagnosis, his generalised dissociative amnesia lasted 6 years and 10 months; however, he recovered from amnesia naturally on starting a new job. Perfusion of his right medial temporal area also returned to normal levels. Longitudinal reports for generalised dissociative amnesia with natural recovery are exceedingly rare. It is important to confirm whether dissociative amnesia and cerebral blood flow recover in parallel, even in cases where dissociative amnesia is long-lasting.
• 不安症・強迫症の診療ガイドライン 社交不安症の診療ガイドライン
  朝倉 聡; 山田 恒; 藤井 泰; 三井 信幸; 吉永 尚紀; 金井 嘉宏
  日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 29回・49回, 45, 45, 日本臨床精神神経薬理学会・日本神経精神薬理学会, 2019年10月
  日本語
• 胃切除後のダンピング症候群を合併し、病態が複雑化した神経性やせ症の一例
  黒鳥 偉作; 三井 信幸; 渡辺 晋也; 賀古 勇輝; 久住 一郎
  精神神経学雑誌, 2019特別号, S423, S423, (公社)日本精神神経学会, 2019年06月
  日本語
• 医学的に不安定な摂食障害患者に対する皮下埋め込み型中心静脈ポートの有用性について
  黒鳥 偉作; 三井 信幸; 曽山 武士; 渡辺 晋也; 賀古 勇輝; 久住 一郎
  精神神経学雑誌, 2019特別号, S428, S428, (公社)日本精神神経学会, 2019年06月
  日本語
• 不安症・強迫症の診療ガイドライン 社交不安症の診療ガイドライン
  朝倉 聡; 山田 恒; 藤井 泰; 三井 信幸; 吉永 尚紀; 金井 嘉宏
  精神神経学雑誌, 2019特別号, S362, S362, (公社)日本精神神経学会, 2019年06月
  日本語
• 【過量服薬A to Z】過量服薬への予防介入 本邦におけるものを中心に
  高信 径介; 渡辺 晋也; 三井 信幸; 賀古 勇輝; 朝倉 聡; 久住 一郎
  臨床精神薬理, 22, 3, 285, 292, (株)星和書店, 2019年03月
  日本語
• Predictive factors for hyperglycaemic progression in patients with schizophrenia or bipolar disorder
  Ichiro Kusumi; Yuki Arai; Ryo Okubo; Minoru Honda; YasuhiroMatsuda; Yukihiko Matsuda; Akihiko Tochigi; Yoshiteru Takekita; Hiroyoshi Yamanaka; Keiichi Uemura; Koichi Ito; Kiyoshi Tsuchiya; Jun Yamada; Bunta Yoshimura; Nobuyuki Mitsui; Sigehiro Matsubara; Takayuki Segawa; Nobuyuki Nishi; Yasufumi Sugawara; Yuki Kako; Ikuta Shinkawa; Kaoru Shinohara; Akiko Konishi; Junichi Iga; Naoki Hashimoto; Shinsaku Inomata; Noriko Tsukamoto; Hiroto Ito; Yoichi M. Ito; Norihiro Sato
  BJPsych Open, 4, 6, 454, 460, 2018年11月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, Background: Patients with schizophrenia or bipolar disorder have a high risk of developing type 2 diabetes. Aims: To identify predictive factors for hyperglycaemic progression in individuals with schizophrenia or bipolar disorder and to determine whether hyperglycaemic progression rates differ among antipsychotics in regular clinical practice. Method: We recruited 1166 patients who initially had normal or prediabetic glucose levels for a nationwide, multisite, l-year prospective cohort study to determine predictive factors for hyperglycaemic progression. We also examined whether hyperglycaemic progression varied among patients receiving monotherapy with the six most frequently used antipsychotics. Results: High baseline serum triglycerides and coexisting hypertension significantly predicted hyperglycaemic progression. The six most frequently used antipsychotics did not significantly differ in their associated hyperglycaemic progression rates over the 1-year observation period. Conclusions: Clinicians should carefully evaluate baseline serum triglycerides and coexisting hypertension and perform strict longitudinal monitoring irrespective of the antipsychotic used. Declaration of interest: The authors report no financial or other relationship that is relevant to the subject of this article. Relevant financial activities outside the submitted work are as follows. I.K. has received honoraria from Astellas, Chugai Pharmaceutical, Daiichi Sankyo, Dainippon Sumitomo Pharma, Eisai, Eli Lilly, Janssen Pharmaceutical, Kyowa Hakko Kirin, Meiji Seika Pharma, MSD, Nippon Chemiphar, Novartis Pharma, Ono Pharmaceutical, Otsuka Pharmaceutical, Pfizer, Tanabe Mitsubishi Pharma, Shionogi and Yoshitomiyakuhin; has received research/grant support from AbbVie GK, Asahi Kasei Pharma, Astellas, Boehringer Ingelheim, Chugai Pharmaceutical, Daiichi Sankyo, Dainippon Sumitomo Pharma, Eisai, Eli Lilly, GlaxoSmithKline, Kyowa Hakko Kirin, Meiji Seika Pharma, MSD, Novartis Pharma, Ono Pharmaceutical, Otsuka Pharmaceutical, Pfizer, Takeda Pharmaceutical, Tanabe Mitsubishi Pharma, Shionogi and Yoshitomiyakuhin; and is a member of the advisory boards of Dainippon Sumitomo Pharma and Tanabe Mitsubishi Pharma. Y.T. has received speaker's honoraria from Dainippon-Sumitomo Pharma, Otsuka, Meiji-Seika Pharma, Janssen Pharmaceutical, Daiichi-Sankyo Company, UCB Japan and Ono Pharmaceutical. K.U. has received honoraria from Dainippon Sumitomo Pharma, Eisai, Eli Lilly, Janssen Pharmaceutical, Kyowa Hakko Kirin, Meiji Seika Pharma, MSD, Takeda Pharmaceutical, Hisamitsu Pharmaceutical, Otsuka Pharmaceutical, Pfizer, Tanabe Mitsubishi Pharma, Shionogi and Yoshitomiyakuhin. B.Y. has received speaker's honoraria from Otsuka Pharmaceutical and Janssen Pharmaceutical. J. I. has received honoraria from Dainippon Sumitomo Pharma, Eli Lilly, Janssen Pharmaceutical, Meiji Seika Pharma, MSD, Novartis Pharma, Otsuka Pharmaceutical and Mochida Pharma.
• Prediction of major depressive episodes and suicide-related ideation over a 3-year interval among Japanese undergraduates.
  Mitsui N; Asakura S; Takanobu K; Watanabe S; Toyoshima K; Kako Y; Ito YM; Kusumi I
  PloS one, 13, 7, e0201047, 2018年, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Suicide has been a leading cause of death among young adult populations in Japan. The aim of this study was to predict major depressive episodes (MDEs) and suicide-related ideation among university students using the Patient Health Questionnaire-9 (PHQ-9) and the Temperament and Character Inventory (TCI). METHODS: The subjects were 2194 university students who completed the PHQ-9 and TCI in the 1st year (T1) and the PHQ-9 in the 4th year (T2) of university. Multiple logistic regression analysis was performed to predict MDEs and suicide-related ideation at T2. Moreover, recursive partitioning analyses were conducted to reveal the future risk of MDEs and suicide-related ideation. RESULTS: The multiple logistic regression analyses of MDEs and suicide-related ideation at T2 revealed that depressive episodes, suicide-related ideation, and low self-directedness(SD) scores at T1 were significant predictors. The area under the curve of the model for MDEs was 0.858 and that for suicide-related ideation was 0.741. The recursive partitioning analyses revealed that a PHQ-9 summary score ≥15 at T1 predicted a high risk of MDEs at T2 and that both a PHQ-9 summary score ≥5 and a PHQ-9 #9 score ≥1 predicted a high risk of suicide-related ideation at T2. CONCLUSIONS: MDEs, suicide-related ideation, and low SD scores are significant predictors of future MDEs and suicide-related ideation.
• Validity and reliability of the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) in Japanese patients with bipolar disorder
  Kuniyoshi Toyoshima; Yutaka Fujii; Nobuyuki Mitsui; Yuki Kako; Satoshi Asakura; Anabel Martinez-Aran; Eduard Vieta; Ichiro Kusumi
  PSYCHIATRY RESEARCH, 254, 85, 89, 2017年08月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Association between suicide-related ideations and affective temperaments in the Japanese general adult population
  Nobuyuki Mitsui; Yukiei Nakai; Takeshi Inoue; Niki Udo; Kan Kitagawa; Yumi Wakatsuki; Rie Kameyama; Atsuhito Toyomaki; Yoichi M. Ito; Yuji Kitaichi; Shin Nakagawa; Ichiro Kusumi
  PLOS ONE, 12, 6, e0179952, 2017年06月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Erratum: Temperament and character profiles of Japanese university students with depressive episodes and ideas of suicide or self-harm: a PHQ-9 screening study (Comprehensive Psychiatry (2013) 54: (1215-1221))
  Nobuyuki Mitsui; Satoshi Asakura; Yusuke Shimizu; Yutaka Fujii; Yuki Kako; Teruaki Tanaka; Koji Oba; Takeshi Inoue; Ichiro Kusumi
  Comprehensive Psychiatry, 62, 218, 2015年10月01日, ［査読有り］
  英語, 研究論文（学術雑誌）
• The structural equation analysis of childhood abuse, adult stressful life events, and temperaments in major depressive disorders and their influence on refractoriness.
  Hiroyuki Toda; Takeshi Inoue; Tomoya Tsunoda; Yukiei Nakai; Masaaki Tanichi; Teppei Tanaka; Naoki Hashimoto; Yasuya Nakato; Shin Nakagawa; Yuji Kitaichi; Nobuyuki Mitsui; Shuken Boku; Hajime Tanabe; Masashi Nibuya; Aihide Yoshino; Ichiro Kusumi
  Neuropsychiatric disease and treatment, 11, 2079, 90, 2015年, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, BACKGROUND: Previous studies have shown the interaction between heredity and childhood stress or life events on the pathogenesis of a major depressive disorder (MDD). In this study, we tested our hypothesis that childhood abuse, affective temperaments, and adult stressful life events interact and influence the diagnosis of MDD. PATIENTS AND METHODS: A total of 170 healthy controls and 98 MDD patients were studied using the following self-administered questionnaire surveys: the Patient Health Questionnaire-9 (PHQ-9), the Life Experiences Survey, the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire, and the Child Abuse and Trauma Scale (CATS). The data were analyzed with univariate analysis, multivariable analysis, and structural equation modeling. RESULTS: The neglect scores of the CATS indirectly predicted the diagnosis of MDD through cyclothymic and anxious temperament scores of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire in the structural equation modeling. Two temperaments - cyclothymic and anxious - directly predicted the diagnosis of MDD. The validity of this result was supported by the results of the stepwise multivariate logistic regression analysis as follows: three factors - neglect, cyclothymic, and anxious temperaments - were significant predictors of MDD. Neglect and the total CATS scores were also predictors of remission vs treatment-resistance in MDD patients independently of depressive symptoms. LIMITATIONS: The sample size was small for the comparison between the remission and treatment-resistant groups in MDD patients in multivariable analysis. CONCLUSION: This study suggests that childhood abuse, especially neglect, indirectly predicted the diagnosis of MDD through increased affective temperaments. The important role as a mediator of affective temperaments in the effect of childhood abuse on MDD was suggested.
• The structural equation analysis of childhood abuse, adult stressful life events, and temperaments in major depressive disorders and their influence on refractoriness
  Hiroyuki Toda; Takeshi Inoue; Tomoya Tsunoda; Yukiei Nakai; Masaaki Tanichi; Teppei Tanaka; Naoki Hashimoto; Yasuya Nakato; Shin Nakagawa; Yuji Kitaichi; Nobuyuki Mitsui; Shuken Boku; Hajime Tanabe; Masashi Nibuya; Aihide Yoshino; Ichiro Kusumi
  NEUROPSYCHIATRIC DISEASE AND TREATMENT, 11, 2079, 2090, 2015年, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• The relationship between insight and subjective experience in schizophrenia
  Yuki Kako; Koki Ito; Naoki Hashimoto; Kuniyoshi Toyoshima; Yusuke Shimizu; Nobuyuki Mitsui; Yutaka Fujii; Teruaki Tanaka; Ichiro Kusumi
  Neuropsychiatric Disease and Treatment, 10, 1415, 1422, Dove Medical Press Ltd., 2014年07月29日, ［査読有り］
  英語, 研究論文（学術雑誌）
• [A multicenter study regarding schizophrenia patients' notification of the diagnosis].
  Kako Y; Okubo R; Shimizu Y; Mitsui N; Tanaka T; Kusumi I
  Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 116, 10, 813, 824, 2014年, ［査読有り］, ［国内誌］
  日本語, 研究論文（学術雑誌）, Over 10 years have passed since the Japanese term for "schizophrenia" was changed from "seishin-bunretsu-byo" to "togo-shiccho-sho" in 2002. An awareness survey targeting doctors suggested that notification of the diagnosis has been encouraged since the Japanese name for schizophrenia was changed. However, no heuristic surveys targeting patients themselves have clarified an increased notification rate, and no multicenter studies of the notification rates have been conducted in recent years. This study targeted schizophrenia patients and their attending physicians to investigate the status of notification of the diagnosis at five medical facilities in Hokkaido, Japan. Questionnaires were distributed to the attending physicians of a total of 869 patients; in addition, the patients themselves filled out questionnaires. Questionnaires were collected from 858 physicians, and valid responses were recovered from 529 patients. This study investigated the status of notification of the diagnosis and compared the attributes of patients who were notified (notified group) with those of patients who were not notified (un-notified group). The results of the survey of attending physicians regarding notification of the diagnosis of schizophrenia indicated that a total of 65.0% patients had been notified, with 63.1% of patients being notified that they had "togo-shiccho-sho" and 2.0% of patients being notified that they had "seishin-bunretsu-byo." Physicians were unsure whether patients had been notified in 18.4% of cases. On excluding these cases, the results indicated that over 79.6% of patients had been notified that they had either "togo-shiccho-sho" or "seishin-bunretsu-byo." The patient questionnaire results regarding patients' awareness of the name of their disease showed that 55.2% answered "togo-shiccho-sho," 3.2% answered "seishin-bunretsu-byo," 9.5% answered the name of another disease, 17.4% answered that they did not know the name of their disease, and 14.7% answered that they knew the name of their disease but did not include any specific details. On excluding these unspecified answers, 68.5% of patients were aware that they had either "togo-shiccho-sho" or "seishin-bunretsu-byo." Comparison of the notified with the un-notified group revealed that the period from treatment initiation in the notified group was shorter than that in the un-notified group, and the mean age of the notified group at the time of the survey was lower than that of the un-notified group. Furthermore, significantly more patients started treatment before 2002, when the Japanese name for schizophrenia was changed, in the un-notified group. The results of this study suggested that the change of the Japanese name of schizophrenia to "togo-shiccho-sho" and historical background resulted in more active notification of the diagnosis.
• The association between suicide risk and self-esteem in Japanese university students with major depressive episodes of major depressive disorder
  Nobuyuki Mitsui; Satoshi Asakura; Yusuke Shimizu; Yutaka Fujii; Atsuhito Toyomaki; Yuki Kako; Teruaki Tanaka; Nobuki Kitagawa; Takeshi Inoue; Ichiro Kusumi
  NEUROPSYCHIATRIC DISEASE AND TREATMENT, 10, 811, 816, 2014年, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• The relationship between insight and subjective experience in schizophrenia
  Yuki Kako; Koki Ito; Naoki Hashimoto; Kuniyoshi Toyoshima; Yusuke Shimizu; Nobuyuki Mitsui; Yutaka Fujii; Teruaki Tanaka; Chiro Kusumi
  NEUROPSYCHIATRIC DISEASE AND TREATMENT, 10, 1415, 1422, 2014年, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• The association between suicide risk and self-esteem in Japanese university students with major depressive episodes of major depressive disorder.
  Mitsui N; Asakura S; Shimizu Y; Fujii Y; Toyomaki A; Kako Y; Tanaka T; Kitagawa N; Inoue T; Kusumi I
  Neuropsychiatric disease and treatment, 10, 811, 816, 2014年, ［査読有り］
• Neurocognitive impairments and quality of life in unemployed patients with remitted major depressive disorder
  Yusuke Shimizu; Nobuki Kitagawa; Nobuyuki Mitsui; Yutaka Fujii; Atsuhito Toyomaki; Naoki Hashimoto; Yuki Kako; Teruaki Tanaka; Satoshi Asakura; Ichiro Kusumi
  Psychiatry Research, 210, 3, 913, 918, 2013年12月30日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Temperament and character profiles of Japanese university students with depressive episodes and ideas of suicide or self-harm: a PHQ-9 screening study.
  Nobuyuki Mitsui; Satoshi Asakura; Yusuke Shimizu; Yutaka Fujii; Yuki Kako; Teruaki Tanaka; Koji Oba; Takeshi Inoue; Ichiro Kusumi
  Comprehensive psychiatry, 54, 8, 1215, 21, 2013年11月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, OBJECTIVE: The aim of our study was to reveal the personality traits of individuals with major and other depressive episodes among the young adult population. Furthermore, character traits of individuals with ideas of suicide or self-harm were also investigated in this study. METHODS: The subjects of this study were 1421 university students who completed the Patient Health Questionnaire (PHQ-9) and the Temperament and Character Inventory (TCI). The subjects were divided into three separate groups: the major depressive episode group (N = 41), the other depressive episode group (N = 97), and the non-depressive controls (N = 1283). This separation was achieved using the PHQ-9 algorithm diagnosis. We compared the TCI scores using an analysis of variance. Moreover, the Cochran-Armitage trend test was used to determine the diagnosis, ideas of suicide or self-harm, and analysis of character profiles. RESULTS: The major depressive episode group had significantly higher HA (P < 0.001), lower RD (P < 0.001), lower SD (P < 0.001), and lower C (P < 0.001) scores than non-depressive controls. The other depressive episode group had significantly higher HA scores (P < 0.001) and lower SD scores (P < 0.001) than non-depressive controls. The Cochran-Armitage trend test revealed that the prevalence of depressive episodes decreased as the character profiles matured (χ(2)(trend) = 57.2, P < 0.0001). The same tendency was observed in individuals who had ideas of suicide or self-harm (χ(2)(trend) = 49.3, P < 0.0001). CONCLUSION: High HA and low SD scores were common personality traits among young adults with major depressive episodes. Furthermore, the immaturity of character profiles was clearly associated with depressive episodes and ideas of suicide or self-harm.
• Selegiline remarkably improved stage 5 treatment-resistant major depressive disorder: A case report
  Yuji Kitaichi; Takeshi Inoue; Nobuyuki Mitsui; Shin Nakagawa; Rie Kameyama; Yoshiyuki Hayashishita; Tohru Shiga; Ichiro Kusumi; Tsukasa Koyama
  Neuropsychiatric Disease and Treatment, 9, 1591, 1594, 2013年10月16日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Temperament and character profiles of Japanese university student suicide completers
  Nobuyuki Mitsui; Satoshi Asakura; Takeshi Inoue; Yusuke Shimizu; Yutaka Fujii; Yuki Kako; Teruaki Tanaka; Nobuki Kitagawa; Ichiro Kusumi
  COMPREHENSIVE PSYCHIATRY, 54, 5, 556, 561, 2013年07月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Severity of generalized social anxiety disorder correlates with low executive functioning
  Yutaka Fujii; Nobuki Kitagawa; Yusuke Shimizu; Nobuyuki Mitsui; Atsuhito Toyomaki; Naoki Hashimoto; Yuki Kako; Teruaki Tanaka; Satoshi Asakura; Tsukasa Koyama; Ichiro Kusumi
  Neuroscience Letters, 543, 42, 46, 2013年05月24日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）

• 医療観察法指定入院医療機関におけるclozapine使用状況及び使用ニーズに関する調査
  高信径介; 高信径介; 直江亮; 石川修平; 三井信幸; 賀古勇輝; 賀古勇輝; 橋本直樹; 久住一郎, 臨床精神薬理, 28, 6, 2025年
• 医療観察法指定入院医療機関におけるクロザピン使用状況および使用ニーズに関する調査
  高信径介; 高信径介; 直江亮; 石川修平; 三井信幸; 賀古勇輝; 賀古勇輝; 橋本直樹; 久住一郎, 日本司法精神医学会大会プログラム・抄録集, 20th, 2024年
• 医療観察法関連医療機関におけるクロザピン使用状況および使用ニーズに関する調査
  高信径介; 高信径介; 直江亮; 石川修平; 三井信幸; 賀古勇輝; 賀古勇輝; 橋本直樹; 久住一郎, 日本精神神経学会総会プログラム・抄録集, 120th, 2024年
• 自殺念慮に対する自尊感情の影響について:COVID-19発生後の心理的苦痛と絶望感の媒介効果の変化に関する分析
  NGUYEN TanDat; 三井信幸; 朝倉聡; 朝倉聡; 高信径介; 豊島邦義; 藤井泰; 藤井泰; 賀古勇輝; 久住一郎, 日本不安症学会学術大会プログラム・抄録集, 15th, 2023年
• 改訂版自殺リスクアセスメントシートを用いた精神科入院患者の自殺リスクの定量化と自殺事故予防効果の検討
  高信径介; NGUYEN Tan Dat; 豊島邦義; 三井信幸; 賀古勇輝; 朝倉聡; 久住一郎, 日本自殺予防学会総会プログラム・抄録集, 47th, 2023年
• 大学生における社交不安症およびうつ病発症に与える気質とライフイベントの影響
  藤井泰; 藤井泰; 朝倉聡; 朝倉聡; グエン タンダット; 高信径介; 豊島邦義; 三井信幸; 賀古勇輝; 橋野聡; 久住一郎, 日本不安症学会学術大会プログラム・抄録集, 15th, 2023年
• 社交不安症の診療ガイドライン
  清水 栄司; 井上 猛; 佐々木 司; 熊野 宏昭; 稲田 健; 松永 寿人; 塩入 俊樹; 朝倉 聡; 今井 必生; 竹島 望; 早坂 佑; 馬場 俊明; 山田 恒; 藤井 泰; 三井 信幸; 吉永 尚紀; 金井 嘉宏; 貝谷 久宣; 鈴木 伸一; 奥村 泰之; 有園 正俊; 生坂 政臣; 日本不安症学会, 日本神経精神薬理学会, 不安症研究, 13, 1, 53, 111, 2021年11月
  日本不安症学会, 日本語
• 社交不安症の診療ガイドライン
  清水 栄司; 井上 猛; 佐々木 司; 熊野 宏昭; 稲田 健; 松永 寿人; 塩入 俊樹; 朝倉 聡; 今井 必生; 竹島 望; 早坂 佑; 馬場 俊明; 朝倉 聡; 山田 恒; 藤井 泰; 三井 信幸; 吉永 尚紀; 金井 嘉宏; 貝谷 久宣; 鈴木 伸一; 奥村 泰之; 有園 正俊; 生坂 政臣; 日本不安症学会, 日本神経精神薬理学会, 不安症研究, 13, 1, 53, 111, 2021年11月
  日本不安症学会, 日本語
• 精神科で初療が行われた非けいれん性てんかん重積に関する後ろ向き観察研究
  高柳瞬; 中村悠一; 櫻井高太郎; 三井信幸; 久住一郎, 精神神経学雑誌, 123, 5, 2021年
• 重症神経性やせ症患者に対する皮下埋め込み型中心静脈ポートの有用性に関する検討
  賀古勇輝; 黒鳥偉作; 渡辺晋也; 豊島邦義; 三井信幸; 朝倉聡; 曽山武士; 阿保大介; 久住一郎, 日本摂食障害学会学術集会プログラム・講演抄録集, 23rd, 2019年
• 精神科入院患者に施行した自殺リスクアセスメントシートの有用性の検討
  高信径介; 横浜愛; 渡辺晋也; 豊島邦義; 三井信幸; 三井信幸; 賀古勇輝; 朝倉聡; 朝倉聡; 久住一郎, 日本自殺予防学会総会プログラム・抄録集, 43rd, 2019年
• 緊張病症状にホルモン補充療法が有効であった統合失調症の1例
  岡 松彦; 板橋 彩; 森川 一史; 大宮 友貴; 梅津 弘樹; 三井 信幸, 精神医学, 60, 6, 681, 686, 2018年06月
  (株)医学書院, 日本語
• 行動活性化療法により自己効力感が向上した反復性うつ病性障害の1例
  金子 恭昌; 金子 真由美; 渡邊 智恵; 堀 利奈; 梅津 弘樹; 岡 松彦; 荒井 勇輝; 三井 信幸, 精神医学, 59, 12, 1129, 1134, 2017年12月
  (株)医学書院, 日本語
• 大学生のK-10およびPHQ-9に対する自尊感情および絶望感の影響について
  石原 可愛; 三井 信幸; 朝倉 聡; 武田 弘子; 川島 るい; 小西 優佳; 藤岡 大輔; 橋野 聡, 全国大学保健管理研究集会プログラム・抄録集, 55回, 112, 112, 2017年11月
  (公社)全国大学保健管理協会, 日本語
• 大学生の大うつ病エピソードおよび自殺念慮の予測に関する研究
  三井 信幸; 朝倉 聡; 豊島 邦義; 藤井 泰; 賀古 勇輝; 久住 一郎, 日本うつ病学会総会・日本認知療法・認知行動療法学会プログラム・抄録集, 14回・17回, 266, 266, 2017年07月
  日本うつ病学会・日本認知療法・認知行動療法学会, 日本語
• 食行動異常にて発症し摂食障害との鑑別を要した統合失調症の一例
  袴田 里実; 三井 信幸; 前田 珠希; 豊島 邦義; 藤井 泰; 賀古 勇輝; 柳生 一自; 須山 聡; 斎藤 卓弥; 久住 一郎, 心身医学, 57, 6, 651, 651, 2017年06月
  (一社)日本心身医学会, 日本語
• 当院のうつ病に対するduloxetine、escitalopramの処方調査
  梅津 弘樹; 岡 松彦; 三井 信幸, 精神神経学雑誌, 118, 9, 714, 714, 2016年09月
  (公社)日本精神神経学会, 日本語
• 地方公務員の気質-性格特性とうつ病エピソードの関連について
  三井 信幸; 岡 松彦; 梅津 弘樹, 精神神経学雑誌, 118, 9, 716, 716, 2016年09月
  (公社)日本精神神経学会, 日本語
• SCAP法により多剤大量からaripiprazole単剤へ集約し得た統合失調症の1例
  岡 松彦; 大宮 友貴; 梅津 弘樹; 荒井 勇輝; 三井 信幸, 精神医学, 58, 8, 701, 705, 2016年08月
  (株)医学書院, 日本語
• Screening for diabetes using Japanese blood glucose monitoring guidance in patients with bipolar disorder treated with antipsychotics: A cross-sectional analysis of baseline data
  Ichiro Kusumi; Yuki Arai; Junichi Iga; Yasuhiro Matsuda; Nobuyuki Mitsui; Hiroyuki Muraoka; Kota Ohno; Ryo Okubo; Norihiro Sato; Takayuki Segawa; Kaoru Shinohara; Akihiko Tohigi; Keiichi Uemura; Hiroyoshi Yamanaka, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19, 59, 59, 2016年06月
  英語, 研究発表ペーパー・要旨（国際会議）
• 大学生のうつ病性障害および自殺念慮と性格特性について
  三井 信幸; 朝倉 聡; 清水 祐輔; 藤井 泰; 賀古 勇輝; 田中 輝明; 井上 猛; 久住 一郎, 心身医学, 56, 4, 383, 383, 2016年04月
  (一社)日本心身医学会, 日本語
• 2施設での後方視調査によるblonanserinの用法に関する検討
  岡 松彦; 大宮 友貴; 梅津 弘樹; 高信 径介; 渡辺 晋也; 小川 智生; 古堅 祐行; 岡崎 大介; 三井 信幸, 精神神経学雑誌, 118, 4, 258, 258, 2016年04月
  (公社)日本精神神経学会, 日本語
• Temperament and character profiles of Japanese university student suicide completers (vol 54, pg 556, 2013)
  Nobuyuki Mitsui; Satoshi Asakura; Takeshi Inoue; Yusuke Shimizu; Yutaka Fujii; Yuki Kako; Teruaki Tanaka; Nobuki Kitagawa; Ichiro Kusumi, COMPREHENSIVE PSYCHIATRY, 60, 168, 169, 2015年07月
  英語, その他
• 礼文島における土砂災害後のこころの支援活動に関する報告
  三井 信幸; 荒井 勇輝; 岡 松彦, 精神神経学雑誌, 117, 6, 486, 486, 2015年06月
  (公社)日本精神神経学会, 日本語
• Aripiprazoleにより著明な体重増加を来した症例の検討 ケースシリーズ
  岡 松彦; 大宮 友貴; 橋本 直樹; 荒井 勇輝; 三井 信幸, 精神神経学雑誌, 116, 12, 1040, 1040, 2014年12月
  (公社)日本精神神経学会, 日本語
• 統合失調症患者の病名告知に関する多施設調査
  賀古 勇輝; 大久保 亮; 清水 祐輔; 三井 信幸; 田中 輝明; 久住 一郎, 精神神経学雑誌, 116, 10, 813, 824, 2014年10月
  (公社)日本精神神経学会, 日本語
• 全生活史健忘に関する臨床的検討
  大柳 有加; 賀古 勇輝; 三井 信幸; 久住 一郎, 精神神経学雑誌, 116, 6, 525, 526, 2014年06月
  (公社)日本精神神経学会, 日本語
• うつに対する幼少期ストレス、気質、ライフイベントの影響
  中井 幸衛; 井上 猛; 戸田 裕之; 豊巻 敦人; 中川 伸; 北市 雄士; 仲唐 安哉; 谷知 正章; 林下 善行; 三井 信幸; 橋本 直樹; 久住 一郎, 精神神経学雑誌, 115, 11, 1159, 1159, 2013年11月
  (公社)日本精神神経学会, 日本語
• 大学生の自殺念慮および自傷傾向に関連する気質-性格特性について
  三井 信幸; 朝倉 聡; 小冷 碧; 豊島 邦義; 清水 祐輔; 賀古 勇輝; 田中 輝明; 井上 猛; 久住 一郎, 精神神経学雑誌, 115, 11, 1160, 1160, 2013年11月
  (公社)日本精神神経学会, 日本語
• 統合失調症患者の病名告知に関する多施設調査
  賀古 勇輝; 大久保 亮; 清水 祐輔; 三井 信幸; 田中 輝明; 久住 一郎, 精神神経学雑誌, 2013特別, S, 380, 2013年05月
  (公社)日本精神神経学会, 日本語
• 青年期の大うつ病性障害に伴う自殺念慮に関連する要因について
  三井 信幸; 朝倉 聡; 清水 祐輔; 藤井 泰; 賀古 勇輝; 田中 輝明; 久住 一郎, 精神神経学雑誌, 2013特別, S, 539, 2013年05月
  (公社)日本精神神経学会, 日本語
• 脳炎および認知症との鑑別に苦慮した遅発緊張病の一例
  菊地 未紗子; 三井 信幸; 河合 剛多; 清水 祐輔; 藤井 泰; 賀古 勇輝; 北川 信樹; 中川 伸; 小山 司, 精神神経学雑誌, 2012特別, S, 436, 2012年05月
  (公社)日本精神神経学会, 日本語
• 統合失調症患者の服薬観と関連する要因についての検討
  賀古 勇輝; 石田 七瀬; 清水 祐輔; 三井 信幸; 藤井 泰; 田中 輝明; 北川 信樹; 久住 一郎; 小山 司, 精神神経学雑誌, 2011特別, S, 201, 2011年10月
  (公社)日本精神神経学会, 日本語
• 全般性社交不安障害の顔表情課題遂行時の機能画像に関する研究
  藤井 泰; 北川 信樹; 清水 祐輔; 三井 信幸; 賀古 勇輝; 田中 輝明; 朝倉 聡; 宮本 環; 小山 司, 精神神経学雑誌, 2011特別, S, 236, 2011年10月
  (公社)日本精神神経学会, 日本語
• 統合失調症患者の病名告知と抑うつの関連についての検討
  大久保 亮; 賀古 勇輝; 清水 祐輔; 三井 信幸; 藤井 泰; 田中 輝明; 北川 信樹; 久住 一郎; 小山 司, 精神神経学雑誌, 2011特別, S, 362, 2011年10月
  (公社)日本精神神経学会, 日本語
• 大うつ病性障害患者における認知機能障害と薬物療法の関連性についての検討
  清水 祐輔; 北川 信樹; 豊島 邦義; 三井 信幸; 藤井 泰; 賀古 勇輝; 田中 輝明; 小山 司, 精神神経学雑誌, 2011特別, S, 375, 2011年10月
  (公社)日本精神神経学会, 日本語
• 気分障害患者の自殺傾向と転帰について 北大病院精神科神経科初診患者を対象とした調査
  上川 康友; 清水 祐輔; 三井 信幸; 藤井 泰; 賀古 勇輝; 北川 信樹; 小山 司, 精神神経学雑誌, 113, 4, 422, 422, 2011年04月
  (公社)日本精神神経学会, 日本語
• 統合失調症患者の服薬アドヒアランスと関連する要因についての検討
  石田 七瀬; 賀古 勇輝; 清水 祐輔; 三井 信幸; 藤井 泰; 田中 輝明; 北川 信樹; 久住 一郎; 小山 司, 精神神経学雑誌, 113, 4, 423, 423, 2011年04月
  (公社)日本精神神経学会, 日本語
• 三環系抗うつ薬から選択的セロトニン再取り込み阻害薬へ置換した後に認知機能が改善したうつ病の1例
  豊島 邦義; 清水 祐輔; 三井 信幸; 藤井 泰; 賀古 勇輝; 田中 輝明; 朝倉 聡; 北川 信樹; 小山 司, 精神科, 18, 2, 238, 243, 2011年02月
  三環系抗うつ薬からSSRIへ置換した後、様々な神経認知機能が改善し、職場に適応するなど社会機能回復を認めた大うつ病性障害(MDD)の1例(53歳男性)について報告した。本例のように、抑うつ症状改善後、社会機能障害をきたしてはじめて認知機能障害が疑われるMDD症例は少なくないが、認知機能検査を施行することで、臨床場面では検出困難な軽微な認知機能障害を検出することが可能であると思われた。障害の要因については、疾病そのものの経過や症状レベル、薬剤の影響など様々な側面を考慮する必要があるが、MDDの維持療法を行う際には、認知機能を考慮しながら薬剤変更を試みることには価値があると考えられた。, (有)科学評論社, 日本語
• 三環系抗うつ薬からSSRIへの置換で認知機能が改善したうつ病の1例
  豊島 邦義; 清水 祐輔; 三井 信幸; 藤井 泰; 賀古 勇輝; 北川 信樹; 小山 司, 精神神経学雑誌, 112, 10, 1056, 1056, 2010年10月
  (公社)日本精神神経学会, 日本語
• 修正型電気けいれん療法後のバルプロ酸による維持療法
  三井 信幸; 中川 伸; 黒河 泰夫; 朴 秀賢; 清水 祐輔; 藤井 泰; 賀古 勇樹; 北川 信樹; 井上 猛; 小山 司, 精神神経学雑誌, 2010特別, S, 422, 2010年05月
  (公社)日本精神神経学会, 日本語
• 電気痙攣療法による症状改善後にバルプロ酸単剤による治療で長期間に亘る寛解を維持している精神病性うつ病の1症例
  朴 秀賢; 中川 伸; 三井 信幸; 鈴木 克治; 井上 猛; 小山 司, 精神神経学雑誌, 2010特別, S, 432, 2010年05月
  (公社)日本精神神経学会, 日本語
• 社交不安障害の認知機能 予備的研究(2)
  藤井 泰; 北川 信樹; 清水 祐輔; 三井 信幸; 賀古 勇輝; 朝倉 聡; 小山 司, 不安障害研究, 2, 1, 159, 159, 2010年03月
  日本不安症学会, 日本語
• 医療観察法病棟における入院長期化の要因分析
  三井 信幸; 北川 信樹; 小山 司; 高橋 昇; 石丸 正吾; 中嶋 正人, 精神神経学雑誌, 112, 1, 78, 78, 2010年01月
  (公社)日本精神神経学会, 日本語
• Continuation pharmacotherapy with sodium valproate following successful treatment of electroconvulsive therapy: A 24 week open-label study in depression
  N. Mitsui; S. Nakagawa; S. Boku; Y. Nakatou; K. Suzuki; T. Inoue; T. Koyama, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13, 157, 157, 2010年
  英語, 研究発表ペーパー・要旨（国際会議）
• mECT後の維持療法に抗うつ薬とバルプロ酸の併用投与を行った反復性うつ病性障害の1例
  三井 信幸; 北川 信樹; 中川 伸; 小山 司, 精神科, 15, 5, 488, 492, 2009年11月
  修正型電気けいれん療法(m-ECT)後の早期再燃予防の目的でバルプロ酸(VPA)を追加投与した反復性うつ病性障害の1例(49歳男性)について報告した。m-ECT後には早期に再燃する可能性が高く、確実な維持療法を行うことが課題となっている。本症例では職場復帰に伴う病状の不安定さはみられたが、m-ECT後の早期に抑うつ症状の再燃は認められず、VPAの併用療法が再燃予防に有効であった可能性が考えられた。, (有)科学評論社, 日本語
• 医療観察法病棟における妄想性障害の治療経験
  三井 信幸; 石丸 正吾; 入野 康; 中嶋 正人; 吉住 昭, 精神科, 14, 5, 425, 429, 2009年05月
  医療観察法入院における妄想性障害被害型の症例(40歳代男性)の治療経過について報告した。本症例は持続的な追跡妄想を主症状とし、まったく病識を欠いていたため未治療期間が長く、治療導入が困難であった。しかし、傷害事件を契機として医療観察法入院処遇へと導入され、医療観察法入院の枠組みの中で治療導入し、一定の治療効果が得られた。薬物療法としてはアリピプラゾルを選択し、妄想症状の軽減や病識の獲得などの効果が認められた。以上より、このような妄想性障害に対して医療観察法の入院による治療には一定の効果が期待できることが示唆された。, (有)科学評論社, 日本語
• 医療観察法病棟における妄想性障害の治療経験
  三井 信幸; 石丸 正吾; 中嶋 正人; 吉住 昭, 精神神経学雑誌, 111, 5, 597, 597, 2009年05月
  (公社)日本精神神経学会, 日本語
• 高用量ベンゾジアゼピン投与後にECTを行い寛解に至った緊張型統合失調症の1例
  三井 信幸; 工藤 浩; 黒河 泰夫, 精神神経学雑誌, 110, 6, 508, 508, 2008年06月
  (公社)日本精神神経学会, 日本語
• 治療抵抗性気分障害に対するパルス波治療器を用いた修正型電気痙攣療法における痙攣閾値上昇についての後方視的検討
  Boku Shuken; 梶 直道; 井上 猛; 中川 伸; 鈴木 克治; 田中 輝明; 北市 雄士; 増井 拓哉; 仲唐 安哉; 三井 信幸; 小山 司, 精神神経学雑誌, 2008特別, S, 212, 2008年05月
  (公社)日本精神神経学会, 日本語
• 大うつ病性障害における自殺既遂例の特徴および治療的介入の検討
  三井 信幸; 工藤 浩; 黒河 泰夫, 精神神経学雑誌, 109, 5, 498, 498, 2007年05月
  (公社)日本精神神経学会, 日本語
• 大うつ病性障害における自殺念慮、自殺企図および自殺既遂例の検討
  三井 信幸; 工藤 浩; 黒河 泰夫, 精神神経学雑誌, 2007特別, S146, S146, 2007年05月
  (公社)日本精神神経学会, 日本語
• 大うつ病性障害における自殺既遂例の特徴および治療的介入の検討
  三井 信幸; 工藤 浩; 黒河 泰夫, 岩見沢市立総合病院医誌, 33, 1, 31, 35, 2007年05月
  岩見沢市立総合病院, 日本語
• 大うつ病性障害に対する電気けいれん療法後の維持療法
  三井 信幸; 中川 伸; 北市 雄士; 井上 猛; 小山 司, 岩見沢市立総合病院医誌, 32, 1, 15, 18, 2006年05月
  岩見沢市立総合病院, 日本語
• 単極性うつ病における電気けいれん療法後の維持療法について後方視的研究
  三井 信幸; 中川 伸; 北市 雄士; 井上 猛; 小山 司, 精神神経学雑誌, 108, 5, 539, 539, 2006年05月
  (公社)日本精神神経学会, 日本語
• 完全静脈麻酔(TIVA)による腹部手術の一例
  三井 信幸, 札幌社会保険総合病院医誌, 14, 2, 164, 164, 2005年12月
  (独)地域医療機能推進機構札幌北辰病院, 日本語
• 急性冠症候群の一例
  三井 信幸, 札幌社会保険総合病院医誌, 14, 2, 166, 166, 2005年12月
  (独)地域医療機能推進機構札幌北辰病院, 日本語
• 慢性腎不全から透析導入に至った一例
  三井 信幸, 札幌社会保険総合病院医誌, 14, 1, 72, 72, 2005年04月
  (独)地域医療機能推進機構札幌北辰病院, 日本語
• 特発性下部消化器管穿孔を来した一例
  三井 信幸, 札幌社会保険総合病院医誌, 14, 1, 75, 75, 2005年04月
  (独)地域医療機能推進機構札幌北辰病院, 日本語

• 基本医学研究, 2024年, 修士課程, 医学院
• 基本医学総論, 2024年, 修士課程, 医学院
• 基本医学研究, 2024年, 修士課程, 医学院
• 基本医学総論, 2024年, 修士課程, 医学院
• 応用社会行動科学, 2024年, 修士課程, 医学院
• 医学総論, 2024年, 博士後期課程, 医学院
• 基盤医学研究, 2024年, 博士後期課程, 医学院
• 臨床医学研究, 2024年, 博士後期課程, 医学院
• 医学総論, 2024年, 博士後期課程, 医学院
• 基盤医学研究, 2024年, 博士後期課程, 医学院
• 臨床医学研究, 2024年, 博士後期課程, 医学院

• 2018年10月 - 現在
  日本精神科診断学会
• 日本総合病院精神医学会
• 日本自殺予防学会
• 日本うつ病学会
• 日本精神神経学会
• 日本神経精神薬理学会
• 日本摂食障害学会
• 日本心身医学会
• 日本司法精神医学会