研究者基本情報

• 博士（歯学）, 北海道大学, 2021年03月

• https://researchmap.jp/yasuhito-moritani

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202501011804840774

• 21024506

• 202501011804840774

• ライフサイエンス, 外科系歯学

• 学士課程, 歯学部
• 博士課程, 歯学院

研究活動情報

• 2014年03月, 北海道大学歯学部同窓会賞
• 2013年08月, 日本歯科医師会, スチューデント・クリニシャン・リサーチ・プログラム日本代表選抜大会入賞

• Nonspecific inflammatory pseudotumor of the maxillary and temporal fossa: a study of seven cases.
  Wataru Kakuguchi; Yuichi Ashikaga; Yasuhito Moritani; Shintaro Nakano; Naohiro Ogawa; Rieko Yoshitatsu; Aya Yanagawa-Matsuda; Nako Maishi; Akihiko Kudo; Nanase Okazaki; Yuji Nakamaru; Ichiro Yabe; Yoshihiro Matsuno; Yoichi Ohiro
  Oral surgery, oral medicine, oral pathology and oral radiology, 138, 4, 494, 501, 2024年10月, ［国際誌］
  英語, 研究論文（学術雑誌）, OBJECTIVE: Inflammatory pseudotumor (IPT) is a rare, locally aggressive, benign neoplasm of unknown etiology. Because of its aggressive clinical behavior and locally destructive or infiltrative features, it may be mistaken for a malignant tumor. Approximately 5%-44% of extrapulmonary IPT occur in the head and neck, primarily affecting the orbit. STUDY DESIGN: Between 2008 and 2021, our hospital received referrals for seven patients (three men and four women, aged 42-73 years) with pain, swelling, mass, and trismus. Computed tomography, magnetic resonance imaging, and biopsy were performed on all patients to diagnose IPT. RESULTS: Of the seven patients, four received low-dose prednisolone (PSL), one underwent surgery, and two were left untreated. The IPT disappeared in one of the two untreated cases, whereas it improved and later deteriorated in the other. The surgical patient had no recurrence. Low-dose PSL was effective in two patients; however, high-dose PSL and immunosuppressants were required in the remaining two cases owing to infiltration into each orbit or brain region. CONCLUSIONS: Low-dose PSL treatment was applicable in IPT cases affecting the maxillary to temporal fossa region, wherein symptoms did not improve without treatment. However, when low-dose PSL was ineffective, high-dose PSL and immunosuppressants were required.
• ビスホスホネート内服に関連した上顎骨の広範な骨壊死:病変検出のための骨シンチグラフィーの利用およびHBO療法と手術の併用:症例報告および仮説
  MORITANI Yasuhito; MORITANI Yasuhito; DONEN Masaki; FUJIMORI Masaki; TEI Kanchu; TEI Kanchu; OHIRO Yoichi
  北海道歯学雑誌, 45, 2024年
• 多発性骨髄腫にて骨吸収抑制薬服用中の歯周病患者の残存歯を抜歯してIODに変更し骨関連事象を回避した症例
  吉谷夏純; 吉谷夏純; 吉谷夏純; 川邊功弥; 川邊功弥; 森谷康人; 森谷康人; 松沢祐介; 松沢祐介; 本淨学; 三冨純一; 長谷川健; 和田麻友美; 和田麻友美; 長太一; 長太一; 板橋基雅; 吉谷正純; 北川善政
  日本口腔インプラント学会誌, 37, 2, 2024年
• Histochemical assessment of accelerated bone remodeling and reduced mineralization in Il-6 deficient mice.
  Yasuhito Moritani; Tomoka Hasegawa; Tomomaya Yamamoto; Hiromi Hongo; Yimin; Miki Abe; Hirona Yoshino; Ko Nakanishi; Haruhi Maruoka; Hotaka Ishizu; Tomohiro Shimizu; Masahiko Takahata; Norimasa Iwasaki; Minqi Li; Kanchu Tei; Yoichi Ohiro; Norio Amizuka
  Journal of oral biosciences, 64, 4, 410, 421, 2022年12月, ［国際誌］
  英語, 研究論文（学術雑誌）, OBJECTIVES: Interleukin-6 (IL-6) contributes to the regulation of functions in various tissues and organs. Even though IL-6 has been reported to modulate bone metabolism in previous studies, this finding is controversial. This study aims to evaluate the possible involvement of IL-6 in bone metabolism by examining the histological activity of osteoblasts and osteoclasts in the femora of Il-6 deficient (Il-6-/-) mice. METHODS: Eight-week-old male Il-6-/- mice and their wild-type littermates were fixed with a paraformaldehyde solution, and their femora were extracted for micro-CT analysis, immunohistochemistry, and real-time PCR analysis. RESULTS: Il-6-/- femora showed an increased bone volume/tissue volume (TV) but a reduced bone mineral density compared with the wild-type. Furthermore, the tissue-nonspecific alkaline phosphatase positive area/TV ratio, the expression of Runx2, Osterix, and Rankl, and the number of tartrate-resistant acid phosphatase-positive osteoclasts were all increased in the Il-6-/- mice. A considerable number of unmineralized areas within the bone matrix and abundant sclerostin-reactive osteocytes were observed in Il-6-/- femoral metaphyses but not in the wild-type. Interestingly, the gene expression of Cd206 was elevated in Il-6-/- femora, and many F4/80-positive macrophages/monocytes and CD206-immunoreactive macrophages in the primary trabeculae had migrated closer to the growth plate, where intense RANKL immunoreactivity was detected. These results suggest that, in an IL-6-deficient state, CD206-positive macrophages may differentiate into osteoclasts when in contact with RANKL-reactive osteoblastic cells. CONCLUSION: In a state of IL-6 deficiency, the population and cell activities of osteoblast, osteoclasts, and macrophages seemed to be facilitated, except for the reduced mineralization in bone.
• 歯原性角化嚢胞の患者への“反復処置法”の適用
  OHIRO Yoichi; KAKUGUCHI Wataru; MORITANI Yasuhito; MORITANI Yasuhito; KITAMURA Tetsuya; MAISHI Nako; HIDA Kyoko
  北海道歯学雑誌, 43, 2022年
• 中年期以降に外科的矯正治療を行った骨格性下顎前突の2例
  道念正樹; 森谷康人; 嶋崎康相; 松下和裕; 宮上雄希; 武藤麻未; 高草木祐理; 佐藤嘉晃
  日本顎変形症学会雑誌, 32, 3, 2022年
• Biological application of focus ion beam-scanning electron microscopy (FIB-SEM) to the imaging of cartilaginous fibrils and osteoblastic cytoplasmic processes
  Hasegawa, Tomoka; Endo, Takashi; Tsuchiya, Erika; Kudo, Ai; Zhao, Shen; Moritani, Yasuhito; Abe, Miki; Yamamoto, Tomomaya; Hongo, Hiromi; Tsuboi, Kanako; Yoshida, Taiji; Nagai, Tomoya; Khadiza, Naznin; Yokoyama, Ayako; Luiz de Freitas, Paulo Henrique; Li, Minqi; Amizuka, Norio
  Journal of Oral Biosciences, 59, 1, 55, 62, 2017年02月
  英語, 研究論文（学術雑誌）, Objectives: The aim of this study is a biological application of focused ion beam-scanning electron microscopy (FIB-SEM) to demonstrate serial sectional images of skeletal tissues, here presenting the ultrastructure of 1) cartilaginous extracellular fibrils and 2) osteoblastic cytoplasmic processes.
  Methods: Seven weeks-old female wild-type mice were fixed with half-Karnovsky solution and subsequent OsO4, and the tibiae were extracted for block staining prior to observation under transmission electron microscope (TEM) and FIB-SEM.
  Results: TEM showed the fine fibrillar, but somewhat amorphous ultrastructure of the intercolumnar septa in the growth plate cartilage. Alternatively, FIB-SEM revealed bundles of stout fibrils at regular intervals paralleling the septa’s longitudinal axis, as well as vesicular structures embedded in the cartilaginous matrix of the proliferative zone. In the primary trabeculae, both TEM and FIB-SEM showed several osteoblastic cytoplasmic processes on the osteoid, with numbers higher than those seen in the bone matrix. FIB-SEM revealed the agglomeration of cytoplasmic processes beneath the osteoblasts, which formed a tubular continuum extending from those cells. Based on these findings, we postulated that osteoblasts not only extend their cytoplasmic processes through to the bone matrix, but also stack these cell processes on the osteoid of the primary trabeculae.
  Conclusion: Taken together, it is likely that FIB-SEM imaging strategy on serial sections may successfully deliver new insights on the ultrastructure of cartilage and bone tissues.
• Histochemical assessment for osteoblastic activity coupled with dysfunctional osteoclasts in c-src deficient mice.
  Hisashi Toray; Tomoka Hasegawa; Naoko Sakagami; Erika Tsuchiya; Ai Kudo; Shen Zhao; Yasuhito Moritani; Miki Abe; Taiji Yoshida; Tomomaya Yamamoto; Tsuneyuki Yamamoto; Kimimitsu Oda; Nobuyuki Udagawa; Paulo Henrique Luiz de Freitas; Minqi Li
  Biomedical research (Tokyo, Japan), 38, 2, 123, 134, 2017年, ［国内誌］
  英語, 研究論文（学術雑誌）, Since osteoblastic activities are believed to be coupled with osteoclasts, we have attempted to histologically verify which of the distinct cellular circumstances, the presence of osteoclasts themselves or bone resorption by osteoclasts, is essential for coupled osteoblastic activity, by examining c-fos-/- or c-src-/- mice. Osteopetrotic c-fos deficient (c-fos-/-) mice have no osteoclasts, while c-src deficient (c-src-/-) mice, another osteopetrotic model, develop dysfunctional osteoclasts due to a lack of ruffled borders. c-fos-/- mice possessed no tartrate-resistant acid phosphatase (TRAPase)-reactive osteoclasts, and showed very weak tissue nonspecific alkaline phosphatase (TNALPase)-reactive mature osteoblasts. In contrast, c-src-/- mice had many TNALPase-positive osteoblasts and TRAPase-reactive osteoclasts. Interestingly, the parallel layers of TRAPase-reactive/osteopontin-positive cement lines were observed in the superficial region of c-src-/- bone matrix. This indicates the possibility that in c-src-/- mice, osteoblasts were activated to deposit new bone matrices on the surfaces that osteoclasts previously passed along, even without bone resorption. Transmission electron microscopy demonstrated cell-to-cell contacts between mature osteoblasts and neighboring ruffled border-less osteoclasts, and osteoid including many mineralized nodules in c-src-/- mice. Thus, it seems likely that osteoblastic activities would be maintained in the presence of osteoclasts, even if they are dysfunctional.

• 舌下面に生じた膿原性肉芽腫の1例
  川邊功弥; 森谷康人; 高橋(永森)秀佳; 高橋(永森)秀佳; 小野貢伸, 日本口腔科学会雑誌(Web), 73, 3, 2024年
• Application of the dredging method in a case of recurrent ameloblastoma that had spread over a large region of the mandible
  Wataru Kakuguchi; Yoichi Ohiro; Seitaro Nakazawa; Ryo Naito; Yasuhito Moritani; Yoshiyuki Nakamichi; Hiromasa Horimukai; Tetsuya Kitamura; Kanchu Tei, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 32, 1, 44, 48, 2020年01月
  Abstract Ameloblastomas have a high post-surgical recurrence rate. They often recur after simple conservative surgeries, such as enucleation. The dredging method was thus developed as an alternative, conservative treatment of ameloblastoma. This method accelerates new bone formation and enable s surgeons to remove all tumors, leading to lower recurrence rates than deflation and/or enucleation alone. However, no reports have examined whether the dredging method is effective in recurrent cases of ameloblastomas. A 49-year-old male was referred to our hospital due to right mandibular swelling. This patient had been treated for ameloblastoma with the dredging method until 25 years ago at our hospital. The patient was not seen again after 1 year from the last surgery. A clinical and histopathological diagnosis of recurrent ameloblastoma of the right mandible was made. We applied the dredging method, judging it to be adequate for tumor removal while preserving the jaw bone. A panoramic radiograph revealed mandibular bone restoration with each surgery and removal of all tumor cells had been completed. The patient was followed-up and no recurrence of ameloblastoma was found by 1.5 years following his final surgery. Additionally, the patient was permitted to wear dentures. In the present report, we show that the dredging method was applicable for a case of recurrent ameloblastoma that had spread over a large region of the mandible. The dredging method further allowed the patient to restore denture occlusion by preserving the jaw bone., Elsevier BV
• リン酸三カルシウム(TCP)およびリン酸化プルラン(PPL)含有新規骨補填剤による新生骨誘導における組織学的解析
  森本康仁; 長谷川智香; 邱紫せん; 松本愛子; 桐越晶子; 森谷康人; 橋本圭司; 趙申; 前壮功仁; 本郷裕美; 菅谷勉; 吉田靖弘; 網塚憲生, 日本解剖学会総会・全国学術集会講演プログラム・抄録集, 124th, 2019年
• IL-6遺伝子欠損マウスの骨組織における組織化学的解析
  森谷康人; 伊敏; 邱紫せん; 山本知真也; 鄭漢忠; 網塚憲生; 長谷川智香, 日本解剖学会総会・全国学術集会講演プログラム・抄録集, 124th, 2019年
• 地域外傷医療における病院歯科口腔外科の病院相互連携
  藤盛真樹; 小川仁; 西田佳織; 嶋崎康相; 森谷康人; 道念正樹, 口腔顎顔面外傷, 16, 2, 2017年

• 口腔外科小手術ビデオシンポジウム「下顎埋伏智歯抜歯」ストレートハンドピースを駆使した抜歯
  森谷 康人
  令和7年度第3回例会 北海道病院歯科医会 臨床検討会, 2025年11月29日
  2025年11月29日, ［招待講演］
• 上顎洞内に生じた空洞を伴う骨腫の１例
  森谷康人; 川邊功弥; 永森(髙橋)秀佳; 山口響子; 小野貢伸
  第70回日本口腔外科学会総会・学術大会, 2025年11月15日, 日本語, ポスター発表
  2025年11月14日 - 2025年11月16日
• 反復処置法を適用した高齢者下顎エナメル上皮腫の1例
  森谷康人; 川邊功弥; 永森(髙橋)秀佳; 山口響子; 小野貢伸
  第69回日本口腔外科学会総会・学術大会, ポスター発表
  2024年11月22日 - 2024年11月24日
• 反復処置法を適用した高齢者下顎エナメル上皮腫の1例
  森谷康人; 川邊功弥; 永森(髙橋)秀佳; 山口響子; 小野貢伸
  令和6年第2回例会 北海道病院歯科医会 臨床検討会, 2024年09月07日, ポスター発表
  2024年09月07日
• 経時的変化を観察できた外傷性骨嚢胞の1例
  森谷康人; 道念正樹; 篠原早紀
  第68会日本口腔外科学会総会・学術大会, 口頭発表（一般）
  2023年11月10日 - 2023年11月12日
• 病病連携下に反復処置法で治療を行ったエナメル上皮腫
  森谷康人; 道念正樹; 藤盛真樹; 足利雄一
  第66回日本口腔外科学会総会・学術大会, 口頭発表（一般）
  2021年11月12日 - 2021年11月14日
• 乳児に生じた舌下型ガマ腫の1例
  森谷康人; 髙橋秀佳; 中村英司; 小野貢伸
  第46回日本口腔外科学会北日本支部学術集会, 2020年11月02日, 口頭発表（一般）
• 上顎骨骨折が原因と思われた骨吸収抑制薬関連顎骨壊死
  森谷康人; 道念正樹; 藤盛真樹; 嶋崎康相; 角伸博; 小川仁; 鄭漢忠
  第45回日本口腔外科学会北日本支部学術集会, 2019年05月18日, 口頭発表（一般）
• IL-6遺伝子欠損マウスの骨組織における組織化学的解析
  森谷康人; 伊敏; 邱紫旋; 山本智真也; 網塚憲生; 長谷川智香
  第124回日本解剖学会総会・全国学術集会, ポスター発表
  2019年03月27日 - 2019年03月29日