研究者基本情報

• 博士(生命科学), 北海道大学

• https://researchmap.jp/1983nana

• 201101006895582519

• 細胞生物学
• 創薬スクリーニング
• 分子間相互作用
• 酸化ストレス
• 包括脳ネットワーク

• ライフサイエンス, 機能生物化学

• 学士課程, 薬学部
• 修士課程, 生命科学院
• 博士課程, 生命科学院

研究活動情報

• Automating the roter interaction analysis system for medication counseling: A transformer-based deep learning approach with generative AI-augmented data
  Ayako Mori; Satoshi Watabe; Izumi Kato; Katsuya Narumi; Yoh Takekuma; Hayato Kizaki; Shungo Imai; Keisuke Okamoto; Hinata Ueda; Mitsuru Sugawara; Satoko Hori; Masaki Kobayashi
  Research in Social and Administrative Pharmacy, Elsevier BV, 2026年06月, ［査読有り］
  研究論文（学術雑誌）
• Corrigendum to "Quantitative analysis of communication changes in online medication counseling using the Roter Interaction System" [Res Soc Adm Pharm 20 (2024) 36-42].
  Ayako Mori; Izumi Kato; Katsuya Narumi; Yoh Takekuma; Hitoshi Kashiwagi; Yuki Sato; Mitsuru Sugawara; Masaki Kobayashi
  Research in social & administrative pharmacy : RSAP, 2025年12月19日, ［査読有り］, ［国際誌］
  英語
• A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells.
  Yoichiro Fujioka; Shinya Nishide; Toyoyuki Ose; Tadaki Suzuki; Izumi Kato; Hideo Fukuhara; Mari Fujioka; Kosui Horiuchi; Aya O Satoh; Prabha Nepal; Sayaka Kashiwagi; Jing Wang; Mika Horiguchi; Yuko Sato; Sarad Paudel; Asuka Nanbo; Tadaaki Miyazaki; Hideki Hasegawa; Katsumi Maenaka; Yusuke Ohba
  Cell host & microbe, 23, 6, 809, 818, 2018年06月13日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, Influenza A virus (IAV) infection is initiated by the attachment of the viral glycoprotein hemagglutinin (HA) to sialic acid on the host cell surface. However, the sialic acid-containing receptor crucial for IAV infection has remained unidentified. Here, we show that HA binds to the voltage-dependent Ca2+ channel Cav1.2 to trigger intracellular Ca2+ oscillations and subsequent IAV entry and replication. IAV entry was inhibited by Ca2+ channel blockers (CCBs) or by knockdown of Cav1.2. The CCB diltiazem also inhibited virus replication in vivo. Reintroduction of wild-type but not the glycosylation-deficient mutants of Cav1.2 restored Ca2+ oscillations and virus infection in Cav1.2-depleted cells, demonstrating the significance of Cav1.2 sialylation. Taken together, we identify Cav1.2 as a sialylated host cell surface receptor that binds HA and is critical for IAV entry.
• Secretion of Legumain Increases in Conditioned Medium from DJ-1-Knockout Cells and in Serum from DJ-1-Knockout Mice
  Takuya Yamane; Izumi Kato-Ose; Tatsuji Sakamoto; Yoshihisa Nakano
  Open Biochem. J., 12, 29, 35, 2018年, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, Background: Asparaginyl endopeptidase, also known as legumain (EC 3.4.22.34) shows strong activity in the mouse kidney. Legumain is also highly expressed in tumors. DJ-1/PARK7 is a Parkinson's disease- and cancer-associated protein. DJ-1 is a coactivator of various transcription factors. Recently, we reported that transcription of the legumain gene is regulated by p53 through DJ-1. Methods: We measured the secretion levels of legumain in a conditioned medium of DJ-1 knockout cells and in serum from DJ-1 knockout mice using Western blotting and ELISA. We performed immunocytochemical staining of legumain to examine the localization of legumain in DJ-1-knockout cells. Results: We found that the secretion levels of legumain were increased in the conditioned medium of DJ-1-knockout cells and in serum from DJ-1-knockout mice. Dot structures of legumain were also increased in DJ-1-knockout cells. Conclusion: The results suggest that legumain secretion from DJ-1-knockout cells and in mice increases through its increased expression and accumulation in membrane-associated vesicles.
• DJ-1 activates SIRT1 through its direct binding to SIRT1
  Kazuko Takahashi-Niki; Yoko Ganaha; Takeshi Niki; Shota Nakagawa; Izumi Kato-Ose; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 474, 1, 131, 136, 2016年05月, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Epidermal Growth Factor-dependent Activation of the Extracellular Signal-regulated Kinase Pathway by DJ-1 Protein through Its Direct Binding to c-Raf Protein
  Kazuko Takahashi-Niki; Izumi Kato-Ose; Hiroaki Murata; Hiroshi Maita; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
  JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 29, 17838, 17847, 2015年07月, ［査読有り］, ［筆頭著者］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Transcriptional regulation of the legumain gene by p53 in HCT116 cells
  Takuya Yamane; Sato Murao; Izumi Kato-Ose; Lisa Kashima; Motoki Yuguchi; Miyuki Kozuka; Keisuke Takeuchi; Hisakazu Ogita; Iwao Ohkubo; Hiroyoshi Ariga
  Biochemical and Biophysical Research Communications, 438, 4, 613, 618, 2013年09月06日, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Identification of DJ-1-associated regions on human genes from SH-SY5Y cells using chromatin immunoprecipitation sequence technique
  Yamane Takuya; Sugimoto Naoyuki; Maita Hiroshi; Watanabe Kazufumi; Takahashi-Niki Kazuko; Maita Chinatsu; Kato-Ose Izumi; Ishikawa Shizuma; Gao Jian-wei; Kitaura Hirotake; Niki Takeshi; Iguchi-Ariga Sanae MM; Ariga Hiroyoshi
  Mol. Biol., 3, 15, OMICS International, 2013年, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）, DJ-1, a cancer- and Parkinson's disease-associated protein, works as a coactivator to various transcription factors. In this study, DNA fragments that bind to DJ-1 complexes were obtained by a chromatin immunoprecipitation sequencing with an anti-human DJ-1 antibody using chromatin from SH-SY5Y cells. We identified 60 different sequences as potential DJ-1 complex-binding sites in genes. Of sequences identified, expression levels of DJ-1-associated sitecontaining genes for DNA polymerase N, estrogen receptor α and S-adenosylhomocysteine hydrolase like-2 were decreased in DJ-1-knockdown cells and in 6-OHDA-treated cells. These studies suggest that DJ-1 regulates the expression of versatile genes at the transcriptional level and that some of the genes are regulated by DJ-1 in an oxidative status-dependent manner
• Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner
  Izumi Kato; Hiroshi Maita; Kazuko Takahashi-Niki; Yoshiro Saito; Noriko Noguchi; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
  MOLECULAR AND CELLULAR BIOLOGY, 33, 2, 340, 359, 2013年01月, ［査読有り］, ［筆頭著者］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Neuroprotective function of dj-1 in Parkinson's disease
  Hiroyoshi Ariga; Kazuko Takahashi-Niki; Izumi Kato; Hiroshi Maita; Takeshi Niki; Sanae M. M. Iguchi-Ariga
  Oxidative Medicine and Cellular Longevity, 2013, 683920, 2013年, ［査読有り］, ［国際誌］
  英語, 研究論文（学術雑誌）
• Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis
  Shiori Yamaguchi; Takuya Yamane; Kazuko Takahashi-Niki; Izumi Kato; Takeshi Niki; Matthew S. Goldberg; Jie Shen; Kenji Ishimoto; Takefumi Doi; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
  PLOS ONE, 7, 5, e38144, 2012年05月, ［査読有り］, ［国際共著］, ［国際誌］
  英語, 研究論文（学術雑誌）

• 成人T細胞白血病細胞に細胞死を誘導する新規モノクローナル抗体の分子認識機構
  露木貴浩; PABLO Adrian Guillen Poza; 加藤いづみ; 喜多俊介; 長郷巧太; 鷲見正人; 黒木喜美子; 前仲勝実; 前仲勝実; 前仲勝実; 前仲勝実; 前田直良; 前田直良, 日本蛋白質科学会年会(Web), 25th, 2025年
• 成人T細胞白血病細胞に細胞死を誘導するモノクローナル抗体の抗原認識機構
  露木貴浩; 長郷巧太; POZA Pablo Adrian Guillen; 加藤いづみ; 喜多俊介; 鷲見正人; 黒木喜美子; 前仲勝実; 前仲勝実; 前仲勝実; 前仲勝実; 前田直良; 前田直良, 日本薬学会年会要旨集(Web), 145th, 2025年
• 成人T細胞白血病細胞を認識する抗体の抗原認識機構
  長郷巧太; 露木貴浩; POZA Pablo Adrian Guillen; 加藤いづみ; 喜多俊介; 鷲見正人; 黒木喜美子; 前仲勝実; 前仲勝実; 前仲勝実; 前仲勝実; 前田直良, 日本薬学会年会要旨集(Web), 145th, 2025年
• 成人T細胞白血病細胞増殖抑制抗体の抗原ペプチド認識の構造基盤
  露木貴浩; GUILLEN POZA Pablo Adrian; 加藤いづみ; 喜多俊介; 長郷巧太; 鷲見正人; 黒木喜美子; 前仲勝実; 前仲勝実; 前仲勝実; 前仲勝実; 前田直良; 前田直良, 日本蛋白質科学会年会(Web), 24th, 2024年
• HMG-CoAレダクダーゼ活性を阻害するアロニア果汁含有成分の同定
  小塚 美由記; 山根 拓也; 今井 ももこ; 加藤 いづみ; 石井 哲夫; 竹中 重雄; 坂本 龍司; 乾 博; 山本 好男; 大久保 岩男; 中垣 剛典; 中野 長久, 日本生化学会大会プログラム・講演要旨集, 91回, [3P, 253], 2018年09月
  (公社)日本生化学会, 日本語
• インフルエンザウイルス細胞侵入において鍵となる宿主タンパク質の同定
  藤岡 容一朗; 西出 真也; 尾瀬 農之; 加藤 いづみ; 福原 秀雄; 藤岡 真理; 堀内 浩水; 佐藤 絢; Nepal Prabha; 柏木 彩花; Wang Jing; 堀口 美香; Paudel Sarad; 南保 明日香; 宮崎 忠昭; 前仲 勝実; 大場 雄介, 日本細胞生物学会大会講演要旨集, 69回, 61, 61, 2017年05月
  (一社)日本細胞生物学会, 日本語
• インフルエンザウイルス細胞侵入において鍵となる宿主タンパク質の同定
  藤岡容一朗; 西出真也; 尾瀬農之; 加藤いづみ; 福原秀雄; 藤岡真理; 堀内浩水; 佐藤絢; NEPAL Prabha; 柏木彩花; WANG Jing; 堀口美香; PAUDEL Sarad; 南保明日香; 宮崎忠昭; 前仲勝実; 前仲勝実; 大場雄介, 日本細胞生物学会大会(Web), 69th, ROMBUNNO.T8‐04(P2‐028) (WEB ONLY), 61, 2017年05月
  (一社)日本細胞生物学会, 日本語
• Oxidative status of DJ-1-dependent regulation of the p53 signaling
  Izumi Kato; Hiroshi Maita; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga, NEUROSCIENCE RESEARCH, 68, E307, E307, 2010年
  英語, 研究発表ペーパー・要旨（国際会議）

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