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Last Updated :2024/09/20

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Master

Affiliation (Master)

  • Hokkaido University Hospital　Central Clinical Facilities

Affiliation (Master)

  • Hokkaido University Hospital　Central Clinical Facilities

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Profile and Settings

Profile and Settings

  • Name (Japanese)

    Morita

  • Name (Kana)

    Ryo

  • Name

    AAX-4616-2020, 202001002062657960

Achievement

Research Areas

  • Life sciences / Radiology / IVR

Awards

  • 2024/03 2023 JVIR Editor's Award Honoree | Distinguished Laboratory Investigation
     Mechanical Properties of 3D-Printed Transparent Flexible Resin Used for Vascular Model Simulation Compared with Porcine Arteries. 
    受賞者: 森田亮
  • 2021 北大・部局横断シンポジウム助成事業 Gold Award
     高難度医療技術のAIによる難易度解析と超高精細3D血管模型による非侵襲的技術継承を目指した基盤形成
  • 2021 RSNA Certificate of Merit
     Percutaneous Drainage for Postoperative Fluid Collection after Hepato-Biliary Pancreatic Surgery
  • 2019 北海道大学医学研究科 堀田記念基金

Published Papers

  • 膵癌に対する動体追跡放射線治療用の経皮的あるいは経動脈的マーカー留置術の検討
    加藤 大祐, 阿保 大介, 森田 亮, 打浪 雄介, 加藤 徳雄, 山田 亮太, 木野田 直也, 藤井 宝顕, 山崎 康之, 高柳 歩, 青山 英史, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 39 (Suppl.) 191 - 191 1340-4520 2024/04
  • 血管系IVRシミュレーションに適した3Dプリントによる透明柔軟な樹脂を用いた血管モデルの可能性
    森田 亮, 野々山 貴行, 阿保 大介, 曽山 武士, 藤間 憲幸, 今井 哲秋, 高橋 文也, 木野田 直也, 加藤 大祐, 藤井 宝顕, 山崎 康之, 高柳 歩, 濱口 裕行, 亀田 拓人, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 39 (Suppl.) 253 - 253 1340-4520 2024/04
  • 3Dプリント患者個別血管モデルを用いた最適なカテーテル選択 動脈瘤コイル塞栓術の2例
    森田 亮, 阿保 大介, 藤井 宝顕, 木野田 直也, 加藤 大祐, 山崎 康之, 高柳 歩, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 39 (Suppl.) 260 - 260 1340-4520 2024/04
  • 経皮的門脈塞栓術前後門脈4D-flow MRIの評価者間再現性に関する初期検討
    木野田 直也, 阿保 大介, 高柳 歩, 山崎 康之, 藤井 宝顕, 加藤 大祐, 森田 亮, 箕輪 和行, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 39 (Suppl.) 299 - 299 1340-4520 2024/04
  • 当院において経皮経脾静脈アプローチによるIVRを施行した2例
    高柳 歩, 阿保 大介, 森田 亮, 高橋 文也, 木野田 直也, 加藤 大祐, 藤井 宝顕, 山崎 康之, 中西 喜嗣, 荘 拓也, 中井 正人, 平野 聡, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 39 (Suppl.) 304 - 304 1340-4520 2024/04
  • Reimi Suzuki, Yuji Konishi, Kai Makino, Yosuke Wakui, Kazuhiro Mino, Hideki Kawamura, Ryo Morita, Tatsuhiko Kakisaka, Daisuke Abo, Akinobu Taketomi
    Clinical journal of gastroenterology 17 (2) 356 - 362 2024/04 
    We here present a rare case of development of a postoperative pancreatic fistula and breakdown of the pancreaticojejunal anastomosis 8 months after pancreaticoduodenectomy. A 70-year-old man underwent pancreaticoduodenectomy for distal cholangiocarcinoma and initially recovered well. However, 8 months later, he developed abdominal pain and distention and was admitted to our institution with suspected pancreatitis. On the 17th day of hospitalization, he suddenly bled from the jejunal loop and a fluid collection was detected near the pancreaticojejunal anastomosis site. The fluid collection was drained percutaneously. Subsequent fistulography confirmed breakdown of the pancreaticojejunal anastomosis. Considering the patient's overall condition and the presence of postoperative adhesions, we decided to manage him conservatively. An additional drain tube was placed percutaneously from the site of the anastomotic breakdown into the lumen of the jejunum, along with the tube draining the fluid collection, creating a completely new fistula. This facilitated the flow of pancreatic fluid into the jejunum and was removed 192 days after placement. During a 6-month follow-up, there were no recurrences of pancreatitis or a pancreatic fistula. This case highlights the efficacy of percutaneous drainage and creation of an internal fistula as a management strategy for delayed pancreatic fistula and anastomotic breakdown following pancreaticoduodenectomy.
  • SSPPD後の胆管空腸吻合部閉塞に対するsharp recanalizationによる内外瘻化
    岡村 実幸, 阿保 大介, 森田 亮, 松井 あや, 木野田 直也, 加藤 大祐, 藤井 宝顕, 山崎 康之, 高柳 歩, 若林 直人, 平野 聡, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (3) 221 - 221 1340-4520 2024/01
  • 森田 亮, 阿保 大介
    臨床放射線 金原出版(株) 68 (13) 1415 - 1421 0009-9252 2023/12
  • 阿保 大介, 森田 亮
    臨床放射線 金原出版(株) 68 (13) 1435 - 1439 0009-9252 2023/12
  • 森田 亮, 阿保 大介
    臨床放射線 金原出版(株) 68 (13) 1415 - 1421 0009-9252 2023/12
  • 阿保 大介, 森田 亮
    臨床放射線 金原出版(株) 68 (13) 1435 - 1439 0009-9252 2023/12
  • Yusuke Uchinami, Naoki Miyamoto, Daisuke Abo, Ryo Morita, Koji Ogawa, Tatsuhiko Kakisaka, Ryusuke Suzuki, Tomohiko Miyazaki, Hiroshi Taguchi, Norio Katoh, Hidefumi Aoyama
    Journal of radiation research 2023/11/22 
    The SyncTraX series enables real-time tumor-tracking radiotherapy through the real-time recognition of a fiducial marker using fluoroscopic images. In this system, the isocenter should be located within approximately 5-7.5 cm from the marker, depending on the version, owing to the limited field of view. If the marker is placed away from the tumor, the isocenter should be shifted toward the marker. This study aimed to investigate stereotactic body radiotherapy (SBRT) outcomes of primary liver tumors treated with SyncTraX in cases where the isocenter was shifted marginally or outside the planning target volume (PTV). Twelve patients with 13 liver tumors were included in the analysis. Their isocenter was shifted toward the marker and was placed marginally or outside the PTV. The prescribed doses were generally 40 Gy in four fractions or 48 Gy in eight fractions. The overall survival (OS) and local control (LC) rates were calculated using the Kaplan-Meier method. All patients completed the scheduled SBRT. The median distance between the fiducial marker and PTV centroid was 56.0 (interquartile range [IQR]: 52.7-66.7) mm. By shifting the isocenter toward the marker, the median distance between the marker and isocenter decreased to 34.0 (IQR: 33.4-39.7) mm. With a median follow-up period of 25.3 (range: 6.9-70.0) months, the 2-year OS and LC rates were 100.0% (95% confidence interval: 100-100). An isocenter shift makes SBRT with SyncTraX feasible in cases where the fiducial marker is distant from the tumor.
  • 阿保 大介, 森田 亮, 木野田 直也, 加藤 大祐, 藤井 宝顕, 山崎 康之, 高柳 歩, 工藤 與亮
    日本外科感染症学会雑誌 (一社)日本外科感染症学会 20 (3) 289 - 289 1349-5755 2023/11
  • 阿保 大介, 森田 亮, 木野田 直也, 加藤 大祐, 藤井 宝顕, 山崎 康之, 高柳 歩, 工藤 與亮
    日本外科感染症学会雑誌 (一社)日本外科感染症学会 20 (3) 289 - 289 1349-5755 2023/11
  • 短絡路温存門脈-大循環分流術および傍臍静脈塞栓術が有用であった肝硬変合併シャント型肝性脳症の1例
    久居 弘幸, 櫻井 環, 小柴 裕, 飴田 咲貴, 鈴木 慎人, 森田 亮, 木野田 直也, 阿保 大介
    日本門脈圧亢進症学会雑誌 (一社)日本門脈圧亢進症学会 29 (3) 121 - 121 1344-8447 2023/08
  • 短絡路温存門脈-大循環分流術および傍臍静脈塞栓術が有用であった肝硬変合併シャント型肝性脳症の1例
    久居 弘幸, 櫻井 環, 小柴 裕, 飴田 咲貴, 鈴木 慎人, 森田 亮, 木野田 直也, 阿保 大介
    日本門脈圧亢進症学会雑誌 (一社)日本門脈圧亢進症学会 29 (3) 121 - 121 1344-8447 2023/08
  • Naoya Kinota, Hiroyuki Kameda, Bai Xiawei, Takaaki Fujii, Daisuke Kato, Bunya Takahashi, Ryo Morita, Daisuke Abo, Ryusei Majima, Hiroshi Ishii, Kazuyuki Minowa, Kohsuke Kudo
    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2023/05/30 
    PURPOSE: To investigate whether deep cervical lymph node (DCLN) ligation alters intracranial cerebrospinal fluid (CSF) tracer dynamics and outflow using a rat model with intrathecal dynamic contrast-enhanced (DCE) MRI. METHODS: Six bilateral DCLN-ligated and six sham-operated rats were subjected to DCE MRI with Gd-BTDO3A, and dynamic T1-weighted images were acquired. ROIs were collected from the CSF at the C1 level (CSF_C1), CSF between the olfactory bulbs (CSF_OB), CSF at the pituitary recess (CSF_PitR), and CSF at the pineal recess (CSF_PinR), upper nasal turbinate (UNT), olfactory bulbs, cerebrum, and the jugular region. Time-intensity curves were evaluated, and the maximum slope, peak timing, peak signal ratio, and elimination half-life for the four CSF ROIs and UNT were calculated and compared. RESULTS: Delayed tracer arrival in the rostral CSF space and the nasal cavity with tracer retention in the ventral CSF space were observed in the ligation group. The maximum slopes were smaller in the ligation group at UNT (sham: 0.075 ± 0.0061, ligation: 0.044 ± 0.0086/min, P = 0.011). A significant difference was not detected in peak timings. The peak signal ratio values were lower in the ligation group at UNT (sham: 2.12 ± 0.19, ligation: 1.72 ± 0.11, P = 0.011). The elimination half-life was delayed in the ligation group at CSF_C1 (sham: 30.5 ± 2.70, ligation: 44.4 ± 12.6 min, P = 0.043), CSF_OB (sham: 30.2 ± 2.67, ligation: 44.8 ± 7.47 min, P = 0.021), and CSF_PitR (sham: 30.2 ± 2.49, ligation: 41.3 ± 7.57 min, P = 0.021). CONCLUSION: The DCLN ligation in rats blocked CSF outflow into the nasal cavity and caused CSF retention.
  • 腹部手術後門脈狭窄/閉塞に対する門脈ステント留置による血液検査データ変化に関する検討
    木野田 直也, 阿保 大介, 木村 輔, 作原 祐介, 藤井 宝顕, 加藤 大祐, 高橋 文也, 森田 亮, 折茂 達也, 柿坂 達彦, 中村 透, 平野 聡, 箕輪 和行, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 205 - 205 1340-4520 2023/04
  • 肝左葉尾状葉切除術後の門脈狭窄、右肝動脈出血に対しstentgraft留置が奏功した一例
    村本 朋之, 阿保 大介, 森田 亮, 高橋 文也, 木野田 直也, 加藤 大祐, 藤井 宝顕, 田中 公貴, 中西 喜嗣, 野路 武寛, 平野 聡, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 205 - 205 1340-4520 2023/04
  • 高精細3D血管モデルを用いた術前シミュレーションの有用性(The usefulness of preoperative simulation with 3D-printed patient-specific hollow vascular models)
    森田 亮, 阿保 大介, 曽山 武士, 今井 哲秋, 高橋 文也, 吉野 裕紀, 木野田 直也, 加藤 大祐, 藤井 宝顕, 濱口 裕行, 亀田 拓人, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 38 (Suppl.) 236 - 236 1340-4520 2023/04
  • 4D-flow MRIを用いたportosystemic shunt閉塞前後の門脈血流評価
    加藤 大祐, 阿保 大介, 木野田 直也, 常田 慧徳, 石坂 欣也, 森田 亮, 高橋 文也, 藤井 宝顕, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 237 - 237 1340-4520 2023/04
  • 肝エキノコックス症による右肝静脈狭窄に対してcovered stentを留置した一例
    渡辺 祈一, 阿保 大介, 森田 亮, 木野田 直也, 高橋 文也, 加藤 大祐, 藤井 宝顕, 柿坂 達彦, 折茂 達也, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 277 - 277 1340-4520 2023/04
  • 腹部手術後門脈狭窄/閉塞に対する門脈ステント留置による血液検査データ変化に関する検討
    木野田 直也, 阿保 大介, 木村 輔, 作原 祐介, 藤井 宝顕, 加藤 大祐, 高橋 文也, 森田 亮, 折茂 達也, 柿坂 達彦, 中村 透, 平野 聡, 箕輪 和行, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 205 - 205 1340-4520 2023/04
  • 肝左葉尾状葉切除術後の門脈狭窄、右肝動脈出血に対しstentgraft留置が奏功した一例
    村本 朋之, 阿保 大介, 森田 亮, 高橋 文也, 木野田 直也, 加藤 大祐, 藤井 宝顕, 田中 公貴, 中西 喜嗣, 野路 武寛, 平野 聡, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 205 - 205 1340-4520 2023/04
  • 高精細3D血管モデルを用いた術前シミュレーションの有用性(The usefulness of preoperative simulation with 3D-printed patient-specific hollow vascular models)
    森田 亮, 阿保 大介, 曽山 武士, 今井 哲秋, 高橋 文也, 吉野 裕紀, 木野田 直也, 加藤 大祐, 藤井 宝顕, 濱口 裕行, 亀田 拓人, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 38 (Suppl.) 236 - 236 1340-4520 2023/04
  • 4D-flow MRIを用いたportosystemic shunt閉塞前後の門脈血流評価
    加藤 大祐, 阿保 大介, 木野田 直也, 常田 慧徳, 石坂 欣也, 森田 亮, 高橋 文也, 藤井 宝顕, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 237 - 237 1340-4520 2023/04
  • 肝エキノコックス症による右肝静脈狭窄に対してcovered stentを留置した一例
    渡辺 祈一, 阿保 大介, 森田 亮, 木野田 直也, 高橋 文也, 加藤 大祐, 藤井 宝顕, 柿坂 達彦, 折茂 達也, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌 (一社)日本インターベンショナルラジオロジー学会 38 (Suppl.) 277 - 277 1340-4520 2023/04
  • Ryo Morita, Takayuki Nonoyama, Daisuke Abo, Takeshi Soyama, Fujima Noriyuki, Tetsuaki Imai, Hiroyuki Hamaguchi, Takuto Kameda, Osamu Sugita, Bunya Takahashi, Naoya Kinota, Kohsuke Kudo
    Journal of vascular and interventional radiology : JVIR 34 (5) 871 - 878 2023/01/13 [Refereed]
     
    PURPOSE: To develop a vascular intervention simulation model that replicates the characteristics of a human patient, the mechanical properties of a three-dimensional (3D)- printed transparent flexible resin were compared with those of porcine arteries using the elastic modulus (E) and kinetic friction coefficient (μ_k). MATERIALS AND METHODS: Resin plates were created from transparent flexible resin using a 3D printer. Porcine artery plates were prepared by excising the aorta. E, adhesive strength of resin and arterial surface toward polyethylene plate, was measured with a tensile-compressive mechanical tester. The resin transparency was measured with an ultraviolet-visible light spectrometer. μ_k of the resin plate surface after applying silicone spray for 1-5 s and that of the artery were measured with a translational friction tester. RESULTS: E differed significantly between the arteries and resin plates at each curing time (0.20 ±0.04 vs. 8.53 ±2.37 MPa for a curing time of 1 min, P<0.05). The resin was stiffer than the arteries, regardless of the curing times. The visible light transmittance and adhesive strength of the resin decreased as the curing time increased. The adhesive strength of the artery was the lowest. μ_k of the silicone-coated resin surface created by applying silicone for 2-3 s (thickness of the silicone layer: 1.6-2 μm) was comparable with that of the artery, indicating that the coating imparted a similar slippage to the resin as the living artery. CONCLUSION: Transparent flexible resin is useful for creating a transparent and slippery vascular model for vascular intervention simulation.
  • Yusuke Uchinami, Norio Katoh, Daisuke Abo, Ryo Morita, Hiroshi Taguchi, Yoshihiro Fujita, Takahiro Kanehira, Ryusuke Suzuki, Naoki Miyamoto, Seishin Takao, Taeko Matsuura, Takuya Sho, Koji Ogawa, Tatsuya Orimo, Tatsuhiko Kakisaka, Keiji Kobashi, Hidefumi Aoyama
    The British journal of radiology 96 (1144) 20220720 - 20220720 2023/01/12 
    OBJECTIVES: In a previous study of hepatic toxicity, the following three factors were identified to predict the benefits of proton beam therapy (PBT) for hepatocellular carcinomas (HCC) with a maximum diameter of ≤5 cm and Child-pugh grade A (CP-A): number of tumors (one vs ≥2), the location of tumors (hepatic hilum or others), and the sum of the diameters of lesions. The aim of this study is to analyze the association between these three factors and hepatic toxicity. METHODS: We retrospectively reviewed patients of CP-A treated with PBT or photon stereotactic body radiotherapy (X-ray radiotherapy, XRT) for HCC ≤5 cm. For normal liver dose, the V5, V10, V20 (volumes receiving 5, 10, and 20 Gy at least), and the mean dose was evaluated. The albumin-bilirubin (ALBI) and CP score changes from the baseline were evaluated at 3 and 6 months after treatment. RESULTS: In 89 patients (XRT: 48, PBT: 41), those with two or three (2-3) predictive factors were higher normal liver doses than with zero or one (0-1) factor. In the PBT group, the ALBI score worsened more in patients with 2-3 factors than those with 0-1 factor, at 3 months (median 0.26 vs 0.02, p = 0.032) and at 6 months (median: 0.35 vs 0.10, p = 0.009). The ALBI score change in the XRT group and CP score change in either modality were not significantly different in the number of predictive factors. CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT. ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.
  • Ryo Morita, Daisuke Abo, Taisuke Harada, Takeshi Soyama, Bunya Takahashi, Yuki Yoshino, Naoya Kinota, Taichi Yasui, Kohsuke Kudo
    Radiographics : a review publication of the Radiological Society of North America, Inc 42 (6) E171-E172  2022/10
  • Ryo Morita, Daisuke Abo, Takeshi Soyama, Tetsuaki Imai, Bunya Takahashi, Yuki Yoshino, Naoya Kinota, Hiroyuki Hamaguchi, Takuto Kameda, Kohsuke Kudo
    Radiology case reports 17 (10) 3578 - 3586 2022/10 
    The development of three-dimensional printers has facilitated the creation of patient-specific hollow vessel models. Preoperative simulations using these types of models have improved our ability to select appropriate devices and embolic materials before performing complex endovascular procedures. This report describes 2 cases of high-flow renal arteriovenous fistulas (r-AVFs) that were successfully treated via short-segment embolization using the preloading coil-in-plug (p-CIP) technique. To our knowledge, this is the first report of r-AVF being treated using the p-CIP technique. Our findings demonstrate that preoperative simulation has the potential to improve the safety and reliability of complex vascular embolization procedures.
  • Yuriko Ishida, Masaru Suzuki, Hiroshi Horii, Junichi Nakamura, Munehiro Matsumoto, Sho Nakakubo, Takahiro Sato, Ichizo Tsujino, Ryo Morita, Daisuke Abo, Satoshi Konno
    Internal medicine (Tokyo, Japan) 62 (5) 763 - 767 2022/07/22 
    Pulmonary artery agenesis (PAA) is a rare congenital vascular anomaly usually diagnosed during infancy. We herein report a 67-year-old man with PAA manifesting as massive hemoptysis. Contrast-enhanced computed tomography of the chest revealed the diagnosis of PAA, which we speculated to have resulted in the present event. Detailed angiography provided more accurate information on the pulmonary vasculature and collateral circulation, which helped us plan tailored treatment. Although very rare, we must consider the possibility of PAA in adults with unexplained hemoptysis.
  • 藤好 直, 柿坂 達彦, 松澤 文彦, 下國 達志, 木井 修平, 蔵谷 勇樹, 西川 眞, 森田 亮, 中西 勝也, 高木 智史, 高橋 昌宏
    日本消化器外科学会雑誌 (一社)日本消化器外科学会 55 (6) 389 - 398 0386-9768 2022/06 
    症例は69歳の男性で,盲腸癌術後の多発肝転移に対し,化学療法施行後に経皮経肝門脈塞栓術,肝切除目的に入院となった.経皮経肝門脈塞栓術後2日目に新型コロナウイルス感染症の院内クラスターが発生し,症例も経皮経肝門脈塞栓術後4日目に発症した.抗ウイルス薬やステロイド,抗凝固療法などを早期より開始したが,呼吸状態が悪化し一時は人工呼吸器導入を検討した.しかし,症状が改善し,発症後4週目で酸素投与終了となった.発症8週後に全身状態の改善を認め,術前評価を再度施行後,拡大肝右葉切除,部分切除,術中マイクロ波焼灼を施行した.術後は呼吸障害や血栓形成,著明な肝障害を認めなかった.新型コロナ感染症流行期において,患者因子や環境因子を考慮しつつ,罹患後の治癒切除可能な患者に機を逸せず手術を行うことが重要であると考えられた.(著者抄録)
  • 画像データの実体化による画像診断・IVR技術の高精度化を目指した研究
    阿保 大介, 曽山 武士, 森田 亮
    北海道放射線医学雑誌 (NPO)メディカルイメージラボ 2 26 - 28 2022/03 
    Computed tomography(CT)やMagnetic resonance imaging(MRI)といった2次元画像データを3Dプリンターにて実体化して可視化することで、Interventional Radiology(IVR:画像下治療)を実施するために必要な情報をより正確かつ直感的に取得する、即ち現在よりもより治療の実行に則した精緻な画像診断を行えるようなシステムの構築を行うことと、実体化した血管モデルを対象に術者がカテーテル操作を行って修練することにより高精度のIVR技術を短時間で習得できるようなプロセスを構築することを目的として、画像データの実体化による画像診断・IVR技術の高精度化を目指した研究を開始した。中腔型血管モデルに加えて、さらなる発展型として複数臓器を組み合わせた実体化モデルの作成も目指しており、それらを用いたIVR技術習得の基礎作りが可能となることを想定している。(著者抄録)
  • 藤好直, 柿坂達彦, 松澤文彦, 下國達志, 木井修平, 蔵谷勇樹, 西川眞, 森田亮, 中西勝也, 高木智史, 高橋昌宏
    日本消化器外科学会雑誌(Web) 55 (6) 1348-9372 2022
  • Sho Sosogi, Daisuke Abo, Ryo Morita, Takeshi Soyama, Bunya Takahashi, Yuki Yoshino, Koji Yamasaki, Noriyuki Miyamoto, Kohsuke Kudo
    Interventional Radiology 2022
  • Ryo Morita, Daisuke Abo, Naoya Kinota, Takeshi Soyama, Bunya Takahashi, Yuki Yoshino, Satonori Tsuneta, Kohsuke Kudo
    Radiology case reports 16 (8) 2007 - 2011 2021/08 
    A 40-year-old female (gravida 3 para 1) presented with menstrual, urinary, and anal pain. Computed tomography revealed type II acquired uterine arteriovenous malformation, a common dilated venous sac with bilateral uterine arteries, and multiple branches of iliac arteries draining to the bilateral ovarian veins. Venous sac transvenous embolization via the left ovarian vein of dominant outflow was planned, since complete arteriovenous malformation occlusion was difficult with super-selective transarterial embolization of multiple feeders. Therefore, transarterial embolization of the minor feeder was performed before completing transvenous embolization using coils and 50% glue under left iliac artery flow control. Immediately thereafter, angiography confirmed the complete disappearance of the uterine arteriovenous malformation, and all pain symptoms remitted. In conclusion, transvenous embolization combined with adjunctive transarterial embolization can be an effective and radical treatment for type II uterine arteriovenous malformations.
  • Yusuke Uchinami, Norio Katoh, Daisuke Abo, Hiroshi Taguchi, Koichi Yasuda, Kentaro Nishioka, Takeshi Soyama, Ryo Morita, Naoki Miyamoto, Ryusuke Suzuki, Takuya Sho, Masato Nakai, Koji Ogawa, Tatsuhiko Kakisaka, Tatsuya Orimo, Toshiya Kamiyama, Shinichi Shimizu, Hidefumi Aoyama
    Hepatology research : the official journal of the Japan Society of Hepatology 51 (8) 870 - 879 2021/04/24 
    AIM: To report the outcomes of stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system for hepatocellular carcinoma patients. METHODS: From January 2005 to July 2018, 63 patients with 74 lesions with a maximum diameter ≤52 mm were treated by stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system. No patient with a Child-Pugh Score ≥9 was included, and 85.6% had a score of 5 or 6. Using the biological effective dose (BED) with an α/β ratio of 10 (BED10 ), the median dose in BED10 at the reference point was 76.8 Gy (range 60-122.5 Gy). Overall survival (OS) and local control rates were assessed using the Kaplan-Meier method. RESULTS: With a median follow-up period of 24.6 months (range 0.9-118.4 months), the 1-year and 2-year OS rates were 86.8% (95% confidence interval [95% CI] 75.8-93.3) and 71.1% (57.8-81.6), respectively. The 2-year OS was 89.6% in patients with the baseline modified albumin-bilirubin (mALBI) grade =1, and 61.7% in patients with grade ≥2a. In the multivariate analysis, the mALBI grade (=1 vs. ≥2a) was a significant factor for OS (p = 0.028, 95% CI 1.11-6.18). The 1-year and 2-year local control rates were 100% (100-100%) and 92.0% (77.5-97.5%). The local control rates were significantly higher in the BED10 ≥100 Gy group than in the BED10 <100 Gy group (2-year 100% vs. 86.5%, p = 0.049) at the reference point. CONCLUSION: This retrospective study of stereotactic body radiotherapy using real-time tumor-tracking radiotherapy for hepatocellular carcinoma showed favorable outcomes with lower incidence of toxicities, especially in patients treated with BED10 ≥100 Gy to the reference point.
  • Ryo Morita, Daisuke Abo, Yusuke Sakuhara, Takeshi Soyama, Norio Katoh, Naoki Miyamoto, Yuusuke Uchinami, Shinichi Shimizu, Hiroki Shirato, Kohsuke Kudo
    Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy 29 (6) 334 - 343 2020/12 
    Purpose: This study evaluated the success rate and complications of percutaneous implantation of hepatic fiducial true-spherical gold markers for real-time adaptive radiotherapy (RAR), which constitutes real-time image-guided radiotherapy with gating.Material and methods: We retrospectively evaluated 100 patients who underwent 116 percutaneous intrahepatic implantations of 2-mm-diameter, spherical, gold fiducial markers before RAR from 1999 to 2016, with Seldinger's method. We defined technical success as marker placement at the intended liver parenchyma, without mispositioning, and clinical success as successful tracking of the gold marker and completion of planned RAR. Complications related to marker placement were assessed.Results: The technical success rate for true-spherical gold marker implantation was 92.2% (107/116). Nine of 116 markers migrated (intra-procedurally in seven patients, delayed in two patients). Migration out of the liver (n = 4) or intrahepatic vessels (n = 5) occurred without complications; these markers were not retrieved. The clinical success rate was 100.0% (115/115). Abdominal pain occurred in 16 patients, fever and hemorrhage in seven patients each, and pneumothorax and nausea in one patient each. No major complications were encountered.Conclusions: Percutaneous transhepatic implantation of true-spherical gold markers for RAR is feasible and can be conducted with a high success rate and low complication rate.
  • Satonori Tsuneta, Daisuke Abo, Noriko Oyama-Manabe, Chihoko Miyazaki, Yuki Yoshino, Ryo Morita, Takeshi Soyama, Kohsuke Kudo
    Cardiovascular and interventional radiology 43 (10) 1557 - 1560 0174-1551 2020/10 
    A 54-year-old man was admitted to our hospital with dyspnea and heart failure. Contrast-enhanced computed tomography showed a giant pelvic arteriovenous malformation (AVM) fed by the left internal iliac artery (IIA), right IIA, and inferior mesenteric artery. (IMA). The AVM was treated with selective embolization via the left IIA. Time-resolved three-dimensional phase-contrast magnetic resonance imaging (4D-flow MRI) visualized a gradual flow reduction in the left IIA, whereas the flow in the IMA and right IIA increased relatively. After four sessions, the patient experienced symptom relief and the blood level of N-terminal prohormone brain natriuretic peptide decreased. To the best of our knowledge, we present the first reported use of 4D-flow MRI to quantitatively assess flow reduction in the case of pelvic AVM after embolization.
  • Ryo Morita, Daisuke Abo, Takeshi Soyama, Yuki Yoshino, Toru Yoshikawa, Tasuku Kimura, Kohsuke Kudo
    CVIR endovascular 3 (1) 37 - 37 2020/07/26 
    BACKGROUND: Vascular abnormalities in neurofibromatosis type 1 (NF1) are rare, but are the second leading cause of death in persons with NF1. In NF1 vasculopathy (NF-V), fatal bleeding due to a spontaneous arterial rupture sometimes occurs. Ruptured extracranial arteries in patients with NF1 often involve thoracic vessels, such as the intercostal and subclavian arteries; very few reports exist regarding the abdominal region. Herein, we present the first case of intraperitoneal bleeding due to spontaneous pancreatic arcade artery (PAA) rupture associated with NF1, successfully treated by transcatheter arterial embolization (TAE) combined with stent-graft placement and partial intra-aortic balloon occlusion (IABO). CASE PRESENTATION: A 40-year-old woman complained of back and abdominal pain. Upon admission, her blood pressure was 85/41 mmHg and heart rate was 129 beats/min. Computed tomography (CT) showed large intraperitoneal bleeding due to PAA rupture. After CT scanning, her systolic blood pressure decreased to 50 mmHg. Therefore, we performed emergency TAE with partial IABO. She was treated by TAE of the anterior superior pancreaticoduodenal artery, anterior inferior pancreaticoduodenal artery, and inferior pancreaticoduodenal artery. However, even after TAE, minor extravasation around the superior mesenteric artery continued, and her vital signs remained unstable. Stent-graft placement was selected to stop the haemorrhage, preserving normal blood flow of the superior mesenteric artery trunk. Excellent patency of the stent graft was confirmed on follow-up CT, and she was discharged on postoperative day 56. CONCLUSION: PAA rupture associated with NF1 can be successfully treated by TAE combined with partial intra-aortic balloon occlusion, and stent-graft placement.
  • Morita Ryo, Abo Daisuke, Soyama Takeshi, Takahashi Bunya, Yoshino Yuki, Yamasaki Koji, Kudo Kohsuke
    The Official Journal of the Japanese Society of Interventional Radiology 一般社団法人日本インターベンショナルラジオロジー学会 35 (2) 113 - 126 1340-4520 2020 
    Post-operative complications such as abdominal fluid collection, abscess, bile leakage (BL) and pancreatic fistula (PF) can occur after hepato-biliary pancreatic surgery. Effective drainage is essential for these post-operative complications. Here, we describe non-vascular IR techniques for post-operative complications after hepato-biliary pancreatic surgery, showing our cases.
  • N. Katoh, Y. Uchinami, D. Abo, S. Takao, T. Inoue, H. Taguchi, R. Morita, T. Soyama, T. Hashimoto, R. Onimaru, A. Prayongrat, M. Tamura, T. Matsuura, S. Shimizu, H. Shirato
    International Journal of Radiation Oncology*Biology*Physics 105 (1) E222 - E223 0360-3016 2019/09
  • Naoki Miyamoto, Kenichiro Maeda, Daisuke Abo, Ryo Morita, Seishin Takao, Taeko Matsuura, Norio Katoh, Kikuo Umegaki, Shinichi Shimizu, Hiroki Shirato
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) 65 33 - 39 2019/09 
    PURPOSE: To quantitatively evaluate and compare the image recognition performance of multiple fiducial markers available in real-time tumor-tracking radiation therapy (RTRT). METHODS: Clinically available markers including sphere shape, coil shape, cylinder shape, line shape, and ball shape (folded line shape) were evaluated in liver and lung models of RTRT. Maximum thickness of the polymethyl metacrylate (PMMA) phantom that could automatically recognize the marker was determined by template-pattern matching. Image registration accuracy of the fiducial marker was determined using liver RTRT model. Lung RTRT was mimicked with an anthropomorphic chest phantom and a one-dimensional motion stage in order to simulate marker motion in heterogeneous fluoroscopic images. The success or failure of marker tracking and image registration accuracy for the lung model were evaluated in the same manner as that for the liver model. RESULTS: All fiducial markers except for line shape and coil shape of thinner diameter were recognized by the PMMA phantom, which is assumed to have the typical thickness of an abdomen, with two-dimensional image registration accuracy of <2 pixels. Three-dimensional calculation error with the use of real-time stereoscopic fluoroscopy in RTRT was thought to be within 1 mm. In the evaluation using the lung model, the fiducial markers were recognized stably with sufficient accuracy for clinical application. The same was true for the evaluation using the liver model. CONCLUSIONS: The image recognition performance of fiducial markers was quantified and compared. The results presented here may be useful for the selection of fiducial markers.
  • Ryo Morita, Daisuke Abo, Takeshi Soyama, Yusuke Sakuhara, Masayoshi Kajiyama, Kohsuke Kudo
    Interventional Radiology 3 (2) 88 - 92 2018/06/30 [Not refereed]
     
    A 50-year-old woman with liver dysfunction complained of back pain. Computed tomography showed multiple fusiform aneurysms in the right and left hepatic arteries. As she was hemodynamically stable, antihypertensive therapy was selected to reduce the risk of rupture. During hospitalization, spontaneous and progressive thrombosis formation of multiple hepatic artery aneurysms was observed. She was diagnosed with segmental arterial mediolysis based on her clinical course and imaging findings, and she was discharged after 48 days. One year following discharge, computed tomography showed complete recovery and patent, normal hepatic arterial branches. Segmental arterial mediolysis should be considered as a condition that can cause multiple hepatic artery aneurysms, which can be treated successfully with antihypertensive therapy and careful follow-up observation with imaging when the patient's hemodynamic state is stable.
  • Abo Daisuke, Hirano Satoshi, Nakamura Toru, Soyama Takeshi, Morita Ryo, Yoshino Yuki, Kimura Tasuku, Kanaya Motoma, Koizumi Fuki, Kudo Kohsuke
    The Official Journal of the Japanese Society of Interventional Radiology 一般社団法人日本インターベンショナルラジオロジー学会 33 (3) 229 - 235 1340-4520 2018 
    Distal pancreatectomy with en bloc celiac axis resection (DP-CAR) was designed to provide microscopically negative margins of the celiac artery, nerve plexus, and retroperitoneal tissue for patients with locally advanced pancreatic body cancer. We have been routinely performing the preoperative embolization of CHA for those patients scheduled for DP-CAR since August 1998, to limit the post-surgical ischemic complications of the liver, gall bladder and stomach, by maintaining the blood supply through development of collateral pathways via the superior mesenteric artery and pancreatic arcade. When performing preoperative CHA embolization, it is important to preserve the proper hepatic artery and gastroduodenal artery in order to develop the collateral pathways. It is also preferable to preserve a more than 5-mm length of the distal CHA for easier ligation at surgery. We employed several conventional embolization techniques. However, migration of embolic material from CHA occurred in several patients. From these experiences, we developed an embolization technique using two simultaneous microcatheters and interlocking detachable coils (IDCs). We call this a "dual microcatheter-dual IDC (DMDI) technique". The DMDI technique provided an excellent high success rate than conventional technique. Recently, embolization technique using amplatzer vascular plug4 (AVP4) has become an good alternative to DMDI technique due to its excellent ease of positioning of AVP4.
  • Takeshi Soyama, Daisuke Yoshida, Yusuke Sakuhara, Ryo Morita, Daisuke Abo, Kohsuke Kudo
    Cardiovascular and interventional radiology 40 (6) 947 - 952 0174-1551 2017/06 
    The steerable microcatheter (SwiftNINJA, Sumitomo Bakelite, Tokyo, Japan), which has a remote-controlled flexible tip manipulated using a dial in the handgrip, was recently developed and delivered to the market. This device enables the user to change the angle of the microcatheter tip manually, and potentially makes selective catheterisation easier. We evaluated its unique characteristics and utility in selective catheterisation and coil embolization. This article describes: (1) the advantages of this device in catheterisations involving acute angle branches, and (2) a new technique of compact coil packing with the use of intentional folding by the bendable tip of the catheter.
  • Sho Kitagawa, Takahiro Sato, Katsu Yamazaki, Takumi Ohmura, Yoshiyasu Karino, Jouji Toyota, Takashi Hasegawa, Wataru Sakai, Ryo Morita
    Clinical journal of gastroenterology 6 (1) 75 - 9 2013/02 
    Spontaneous hemoperitoneum is an uncommon condition, which may be critical even if treated appropriately. The paraumbilical vein is a portosystemic collateral vein that develops in patients with portal hypertension, and is rarely found to be a source of bleeding. Here we present a case report of spontaneous hemoperitoneum due to rupture of the paraumbilical vein successfully treated with balloon-occluded retrograde transvenous obliteration (B-RTO). A 69-year-old man with cirrhosis due to nonalcoholic steatohepatitis was admitted to our hospital with abdominal distention and pain. Computed tomography revealed hemoperitoneum with a dilated paraumbilical vein, and rupture of the paraumbilical vein was diagnosed to be the cause of anemia. B-RTO was performed via the left femoral vein with upstream embolization using microcoils, and thrombosis of the paraumbilical vein was confirmed after B-RTO. The patient was discharged without complications 20 days after B-RTO and he experienced no further episodes of bleeding during the subsequent 6-month period.
  • Khin K Tha, Satoshi Terae, Akiko Tsukahara, Hiroyuki Soma, Ryo Morita, Ichiro Yabe, Yoichi M Ito, Hidenao Sasaki, Hiroki Shirato
    BMC neurology 12 39 - 39 1471-2377 2012/06/18 
    BACKGROUND: Hyperintense putaminal rim (HPR) is an important magnetic resonance imaging (MRI) sign for multiple system atrophy (MSA). Recent studies have suggested that it can also be observed in normal subjects at 3 T. Whether it can be observed in normal subjects at 1.5 T is not known. This study aimed to determine whether HPR could be observed in normal subjects at 1.5 T; and if so, to establish its prevalence, the MRI characteristics, and the features which distinguish from HPR in MSA patients. METHODS: Axial T2-weighted images of 130 normal subjects were evaluated for the prevalence of HPR, its age and gender distribution, laterality, maximum dimension, association with hypointensity of nearby putamen, and presence of discontinuity. To distinguish from that observed in MSA, axial T2-weighted images of 6 MSA patients with predominant parkinsonism (MSA-P) and 15 MSA patients with predominant cerebellar symptoms (MSA-C) were also evaluated. The characteristics of HPR were compared between these patients and age-matched normal subjects. The mean diffusivity (MD) values of putamen were also compared. Fisher's exact test, t-test, and one way analysis of variance were used to determine significance at corrected p < 0.05. RESULTS: HPR was observed in 38.5% of normal subjects. Age and gender predilection and laterality were not observed. In most cases, it occupied the full length or anterior half of the lateral margin of putamen, and was continuous throughout its length. Maximum transverse dimension was 2 mm. There was no association with hypointensity of nearby putamen. However, in MSA-P, HPR was located predominantly at the posterolateral aspect of putamen, and associated with putaminal atrophy. Discontinuity of HPR was more frequently observed in MSA-P. On visual analysis, the characteristics of HPR were similar between MSA-C patients and normal subjects. Patients with MSA of either type had significantly higher MD values of putamen than normal subjects. CONCLUSIONS: HPR can be observed in 38.5% of normal subjects at 1.5 T. Thin linear hyperintensity without discontinuity, occupying the full length or anterior half of the lateral margin of the putamen, is suggestive of "normal." In doubtful cases, measurement of the MD values of nearby putamen may be valuable.

MISC

Presentations

  • 阿保 大介, 曽山 武士, 森田 亮, 高橋 文也, 木野田 直也, 安井 太一, 工藤 與亮
    日本外科感染症学会雑誌  2021/11  (一社)日本外科感染症学会
  • 宮崎 あすか, 亀田 啓, 大江 悠希, 泉原 里美, 重沢 郁美, 野本 博司, 曹 圭龍, 中村 昭伸, 坂本 圭太, 森田 亮, 曽山 武士, 阿保 大介, 工藤 與亮, 三好 秀明, 渥美 達也
    日本内分泌学会雑誌  2021/10  (一社)日本内分泌学会
  • 肝胆膵術後膵液瘻のドレナージ治療の基本と工夫
    阿保 大介, 曽山 武士, 森田 亮, 高橋 文也, 木野田 直也, 工藤 與亮
    日本医学放射線学会秋季臨床大会抄録集  2021/08  (公社)日本医学放射線学会
  • 開放創部の術後リンパ漏に対しリンパ管塞栓術が有効であった一例(Glue in open wound directly confirmed with intranodal glue embolization for groin lymphorrhea)
    曽々木 昇, 森田 亮, 山崎 康之, 阿保 大介, 曽山 武士, 高橋 文也, 吉野 裕紀, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2021/04  (一社)日本インターベンショナルラジオロジー学会
  • 胃静脈瘤に対する経皮経門脈的塞栓術の経験
    高橋 文也, 阿保 大介, 曽山 武士, 森田 亮, 吉野 裕紀, 山崎 康之, 曽々木 昇, 宮本 憲幸, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2021/04  (一社)日本インターベンショナルラジオロジー学会
  • 肝エキノコックス症による門脈狭窄に対しバルーン拡張型カバードステントを留置した1例
    山崎 康之, 阿保 大介, 森田 亮, 吉野 裕紀, 高橋 文也, 曽山 武士, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2021/04  (一社)日本インターベンショナルラジオロジー学会
  • 肺動静脈奇形に対する4D flow MRIによる血流評価の実行可能性に関する検討
    阿保 大介, 常田 慧徳, 曽山 武士, 森田 亮, 吉野 裕紀, 高橋 文也, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2021/04  (一社)日本インターベンショナルラジオロジー学会
  • Type 3大動脈弓模型の3分枝へのカテーテライゼーション(Catheterization into branches of simplified type 3 arch models)
    曽山 武士, 今井 哲秋, 吉野 裕紀, 高橋 文也, 森田 亮, 阿保 大介, 吉田 大介, 東海林 菊太郎, 長内 俊也, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2021/04  (一社)日本インターベンショナルラジオロジー学会
  • 尿管動脈瘻に対して血管内治療を行なった1例
    杉戸 悠紀, 山田 修平, 千葉 博基, 堀田 記世彦, 木野田 直也, 森田 亮, 阿保 大介, 篠原 信雄
    泌尿器外科  2021/03  医学図書出版(株)
  • 阿保 大介, 曽山 武士, 森田 亮, 高橋 文也, 吉野 裕紀, 工藤 與亮
    日本外科感染症学会雑誌  2020/10  (一社)日本外科感染症学会
  • 肺動静脈奇形に対し卵円孔経由で経静脈的塞栓術を施行した1例
    阿保 大介, 曽山 武士, 永井 利幸, 森田 亮, 吉野 裕紀, 木野田 直也, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2020/08  (一社)日本インターベンショナルラジオロジー学会
  • 外腸骨動脈破裂を来たした子宮頸癌治療後難治性腸管穿孔の1例
    木野田 直也, 森田 亮, 阿保 大介, 曽山 武士, 吉野 裕紀, 工藤 與亮, 野崎 綾子, 加藤 達矢, 渡利 英道
    日本インターベンショナルラジオロジー学会雑誌  2020/08  (一社)日本インターベンショナルラジオロジー学会
  • 子宮動脈-卵巣動脈吻合枝領域からの出血をNBCAで塞栓した1例
    渡辺 祈一, 森田 亮, 阿保 大介, 曽山 武士, 吉野 裕紀, 木野田 直也, 加藤 扶美, 桜井 康雄, 児玉 芳尚, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2020/08  (一社)日本インターベンショナルラジオロジー学会
  • 子宮動静脈奇形に対し動脈塞栓術併用経静脈的塞栓術を施行した1例
    森田 亮, 阿保 大介, 木野田 直也, 曽山 武士, 吉野 裕紀, 常田 慧徳, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2020/08  (一社)日本インターベンショナルラジオロジー学会
  • Up-to-7 inのHCC患者において超選択的TACEは選択的TACEに対しsurvival benefitを有するか?
    吉野 裕紀, 阿保 大介, 森田 亮, 曽山 武士, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2020/08  (一社)日本インターベンショナルラジオロジー学会
  • 巨大骨盤AVMに対する塞栓術の治療効果を4D-flow MRIにより定量的に評価できた一例(Quantitative evaluation of a giant pelvic arteriovenous malformation by 4D-flow MRI: a case report)
    阿保 大介, 常田 慧徳, 真鍋 徳子, 曽山 武士, 森田 亮, 吉野 裕紀, 木野田 直也, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2020/08  (一社)日本インターベンショナルラジオロジー学会
  • コイル塞栓術における先端可動型マイクロカテーテルの先端ロック機構の有用性の基礎的検討
    阿保 大介, 曽山 武士, 森田 亮, 上石 崇史, 金谷 本真, 高柳 歩, 山崎 康之, 吉野 裕紀, 木村 輔, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2019/05  (一社)日本インターベンショナルラジオロジー学会
  • 膵アーケード破裂に対して動脈塞栓術及びステントグラフト留置により救命しえた神経線維腫症1型の1例
    森田 亮, 阿保 大介, 木村 輔, 上石 崇史, 曽山 武士, 吉野 裕紀, 工藤 興亮
    日本インターベンショナルラジオロジー学会雑誌  2019/05  (一社)日本インターベンショナルラジオロジー学会
  • 左下横隔動脈経由で還流されていた脾動脈に対しPSEを施行した1例
    木村 輔, 阿保 大介, 吉野 裕紀, 森田 亮, 曽山 武士, 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌  2019/04  (一社)日本インターベンショナルラジオロジー学会
  • 救命率を向上させる外科とIVRとのコラボレーション 救命率を向上させる外科とIVRとのコラボレーション症例
    森田 亮, 曽山 武士, 阿保 大介, 工藤 與亮
    Japanese Journal of Acute Care Surgery  2017/09  日本Acute Care Surgery学会
  • 肝腫瘍に対する動態追跡照射のための経皮的マーカ留置(Percutaneous hepatic fiducial marker implantation for Real-time Tumor-tracking Radiotherapy(RTRT))
    森田 亮, 作原 祐介, 曽山 武士, 阿保 大介, 加藤 徳雄, 工藤 與亮, 白土 博樹
    IVR: Interventional Radiology  2017/04  (一社)日本インターベンショナルラジオロジー学会

Research Projects

  • 日本学術振興会：科学研究費助成事業 若手研究
    Date (from‐to) : 2022/04 -2025/03 
    Author : 森田 亮
  • 日本学術振興会：科学研究費助成事業 基盤研究(C)
    Date (from‐to) : 2021/04 -2024/03 
    Author : 阿保 大介, 曽山 武士, 森田 亮, 神山 俊哉
     
    研究開始の初年度は、本研究の実施のコアとなる、経皮的門脈塞栓術を含めた門脈系IVR（カテーテル治療/画像下治療）に対する4D Flow-MRIを用いた門脈系の血流評価に関する前向き観察研究の臨床研究のプロトコル作成とIRB申請を行った。 門脈系の4D-Flow MRIの撮像方法は、まだ定まった方法が存在しないというのが現状である。加えて、これまでの既報では造影剤を併用して実施されている方法が一般的である。しかし、我々は、繰り返し実施する際の患者侵襲（静脈注射による疼痛、腎機能への負担、アレルギー発症リスク等）を無くし、より多くの患者に適応できる方法へ発展させたいという観点から、造影剤を使用せずに（非造影で）評価可能な4D-Flow MRI撮像方法の確立を目指している。 研究初年度の今年度は、前述のように、非造影での4D-Flow MRI 撮像方法の確立と最適化を目指し、数名の健常人ボランティアを用いて血管描出と4D-flow MRIの画像を位置合わせの方法（主にパラメーター設定）を模索した。並行して門脈塞栓術を含めた門脈系IVR前後での4D-Flow MRI症例のリクルート・症例集積及び処置前後における撮像を行い、各症例で得られた知見をフィードバックし、それ以降の症例の撮像方法の改良を継続的に実施した。 また4D-Flow MRIの撮像を行う症例については、門脈塞栓術時の血管造影法についても、4D-Flow MRIと比較・検討することを念頭にプロトコールの改良を実施した。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2020/09 -2022/03 
    Author : Morita Ryo
     
    This study was conducted to develop artificial intelligence (AI) capable of determining the difficulty of catheter insertion into the target vessel for endovascular catheterization. AI analysis was performed based on a difficulty evaluation test for visibility using CT VR data from the celiac artery to the common hepatic artery performed by one specialist in 2020. The results showed that the overall accuracy was relatively good at 89.05% when cases were divided into difficult and non-difficult cases. In 2021, an AI analysis based on a visibility evaluation study by three IVR specialists was performed. The overall accuracy was more than 60% when discriminating between difficult and non-difficult catheter insertion cases and more than 80% when selecting non-difficult cases.

Industrial Property Rights

  • 特開WO2018-038223:骨セメントを活用した放射線治療用の病変識別マーカーおよび放射線治療用の病変識別マーカーキット  2018/03/01
    阿保 大介, 作原 祐介, 森田 亮, 宮本 直樹
  • 特開WO2016-137013:射線治療用の病変識別マーカーおよび放射線治療用の病変識別マーカーキット  2016/09/01
    作原祐介, 高橋文也, 宮本直樹, 森田亮

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