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研究者情報

マスター

アカウント（マスター）

  • 氏名

    舘野　高(タテノ　タカシ), タテノ　タカシ

所属（マスター）

  • 情報科学研究院　生命人間情報科学部門　バイオエンジニアリング分野

所属（マスター）

  • 情報科学研究院　生命人間情報科学部門　バイオエンジニアリング分野

独自項目

syllabus

  • 2021, 生体制御工学特論, Biosystems control and engineering, 修士課程, 情報科学研究科, 中枢神経系，神経シグナル伝達，感覚情報処理とその補償器，脳刺激法，学習・記憶，運動プログラムと制御，神経活動の大規模計測，計算論的神経科学，神経活動の制御技術，脳の機能補償と機能拡張
  • 2021, 神経制御工学特論, Neural Control Engineering, 修士課程, 情報科学院, 中枢神経系，神経シグナル伝達，感覚情報処理とその補償器，脳刺激法，学習・記憶，運動プログラムと制御，神経活動の大規模計測，計算論的神経科学，神経活動の制御技術，脳の機能補償と機能拡張
  • 2021, 生体制御工学特論, Biosystems control and engineering, 博士後期課程, 情報科学研究科, 中枢神経系，神経シグナル伝達，感覚情報処理とその補償器，脳刺激法，学習・記憶，運動プログラムと制御，神経活動の大規模計測，計算論的神経科学，神経活動の制御技術，脳の機能補償と機能拡張
  • 2021, 神経制御工学特論, Neural Control Engineering, 博士後期課程, 情報科学院, 中枢神経系，神経シグナル伝達，感覚情報処理とその補償器，脳刺激法，学習・記憶，運動プログラムと制御，神経活動の大規模計測，計算論的神経科学，神経活動の制御技術，脳の機能補償と機能拡張
  • 2021, シミュレーション工学, Simulation Engineering, 学士課程, 工学部, シミュレーション，数値解析，連立方程式，数値積分，微分方程式，補間法，近似法，行列の固有値
  • 2021, 情報学 Ⅰ, Introduction to Informatics I, 学士課程, 全学教育, 情報活用，情報社会，情報科学，プログラミング，データサイエンス
  • 2021, 神経工学, Neural Engineering, 学士課程, 工学部, 脳・神経系の構造　神経細胞　シナプス　感覚系の情報処理　記憶と学習　情動と精神疾患　脳活動の記録と制御　脳刺激法　運動の制御

researchmap

プロフィール情報

学位

  • 博士（工学）（大阪大学）

プロフィール情報

  • 姓

    舘野

  • 名

    高

  • ID各種

    201101063301228960

対象リソース

業績リスト

研究キーワード

  • 動的安定性   多電極アレイ   高頻度発火   信号検出   ダイナミッククランプ法   背景雑音   神経細胞   神経回路網   多点計測システム   神経科学   聴覚野   ハイブリッドシステム   電気生理学   神経モデル   大脳皮質神経細胞   ランダムダイナミカルシステム   聴覚系   

研究分野

  • ライフサイエンス / 生体材料学
  • ライフサイエンス / 生体医工学
  • 情報通信 / 知能情報学
  • 情報通信 / 生命、健康、医療情報学

学歴

  • 1992年04月 - 1994年03月   大阪大学   大学院基礎工学研究科   生物工学専攻 博士課程前期
  • 1990年04月 - 1992年03月   大阪大学   基礎工学部   生物工学科

受賞

  • 2024年09月 一般社団法人 日本神経回路学会 令和６年 日本神経回路学会 優秀研究賞
     近赤外光刺激がマウス下丘に及ぼす in vivo神経活動の変調効果 
    受賞者: 佐藤 広務 (指導学生 [当時]),舘野 高(共同受賞)
  • 2024年09月 北海道大学 第10回北海道大学部局横断シンポジウムベストポスター賞
     麻酔薬特異的に表出する脳波バイオマーカーの特徴：Oddball課題が誘発するミスマッチ応答の解析 
    受賞者: 川勝 孝基 (指導学生[当時])
  • 2024年09月 電気学会 電子・情報・システム部門 電気学会 電子・情報・システム部門大会 学生ポスターセッション
     マウス聴覚皮質における局所電気刺激が誘発するスパイク応答の時空間的解析 
    受賞者: 下村 桃子(指導学生 [当時])
  • 2024年03月 電子情報通信学会(IEICE)北海道支部 令和５年度 電子情報通信学会 北海道支部 インターネットシンポジウム 優秀発表賞
     音響圧空間分布推定に基づく超音波駆動の神経可塑性誘発法の開発 ー神経細胞間結合の低侵襲的な制御方法の開発に向けて一 
    受賞者: 柴公晟(指導学生[当時])
  • 2023年09月 電気学会 電子・情報・システム部門 Outstanding Student Presentation Award (Student Competition Session)
     "Construction and evaluation of millimeter-sized coils for modulating mice auditory cortex by magnetic stimulation" 
    受賞者: 吉川隆洋(指導学生 [当時])
  • 2023年09月 電気学会 電子・情報・システム部門 優秀ポスター賞
     「小動物の機能的神経結合の推定を目指した in vivo 局所電磁気刺激と脳波多点計測」 
    受賞者: 川勝孝基(指導学生 [当時])
  • 2023年 令和4年度電子情報通信学会北海道支部学生会インターネットシンポジウム 優秀発表賞
     
    受賞者: 川勝孝基 (指導学生 [当時])
  • 2023年 15th International Conference on Biomedical Electronics and Devices (BioDevices) Best Poster Award
     
    受賞者: 古川凌 (指導学生 [当時])
  • 2022年03月 電子情報通信学会北海道支部学生会 令和3年度電子情報通信学会北海道支部学生会インターネットシンポジウム 優秀発表賞
     
    受賞者: 吉川隆洋 (指導学生 [当時])
  • 2022年 2022 IEEE Sapporo Section Student Paper Contest Best Presentation Award
     
    受賞者: 坂上雅明 (指導学生 [当時])
  • 2022年 IEEE Sapporo Section Best Presentation Award
     2022 IEEE Sapporo Section Student Paper Contest 
    受賞者: 吉川隆洋 (指導学生 [当時])
  • 2022年 令和４年度電気・情報関係学会北海道支部連合大会 若手優秀論文発表賞
     
    受賞者: 佐藤広務 (指導学生[当時])
  • 2021年11月 第36回老化促進モデルマウス（SAM）学会学術大会 若手研究奨励賞
     老化促進モデルマウスにおける難聴および時間処理障害の評価：聴性脳幹反応および音響驚愕反射ギャッププレパルス抑制を用いた研究 
    受賞者: 石坂駿人(指導学生 [当時])
  • 2021年09月 電気学会 電子・情報・システム部門 優秀ポスター賞
     
    受賞者: 古川凌 (指導学生 [当時])
  • 2021年 令和２年度電子情報通信学会北海道支部学生会インターネットシンポジウム 優秀発表賞
     
    受賞者: 古川凌 (指導学生 [当時])
  • 2020年12月 日本神経回路学会 優秀研究賞
     
    受賞者: 須貝俊介氏;および;西川淳氏との共同受賞
  • 2020年 老化促進モデルマウス（SAM）学会 大会長奨励賞
     
    受賞者: 石坂駿人 (指導学生 [当時])
  • 2019年05月 一般社団法人電気学会 電子・情報・システム部門大会 企画賞（2018年）
     
    受賞者: 舘野高
  • 2019年 IEEE Computational Intelligence Society Japan Chapter Young Researcher Award
     
    受賞者: 長内尚之 (指導学生 [当時])
  • 2016年 23rd International Conference on Neural Information Processing (ICONIP2016) Best Student Paper Award
     
    受賞者: 三幣俊輔 (指導学生 [当時])
  • 2010年12月 Daiwa Adrian Daiwa Adrian Prize 2010
     
    受賞者: 合原一幸教授,および,他数名との共同受賞
  • 1999年09月 日本神経回路学会 奨励賞
     
    受賞者: 舘野高

論文

  • Ryo Furukawa, Kouta Kume, Takashi Tateno
    Frontiers in Neruoscience 18 1448365.  2024年09月 [査読有り]
  • Hiromu Sato, Futoshi Sugimoto, Ryo Furukawa, Takashi Tateno
    eNeuro ENEURO.0521 - 23.2024 2024年04月16日 [査読有り]
     
    Infrared neural stimulation (INS) is a promising area of interest for the clinical application of a neuromodulation method. This is in part because of its low invasiveness, whereby INS modulates the activity of neural tissue mainly through temperature changes. Additionally, INS may provide localized brain stimulation with less tissue damage. The inferior colliculus (IC) is a crucial auditory relay nuclei, and a potential target for clinical application of INS to treat auditory diseases and develop artificial hearing devices. Here, using continuous INS with low to high power density, we demonstrate laminar modulation of neural activity in the mouse IC in the presence and absence of sound. We investigated stimulation parameters of INS to effectively modulate neural activity in a facilitatory or inhibitory manner. A mathematical model of INS-driven brain tissue was first simulated, temperature distributions were numerically estimated, and stimulus parameters were selected from the simulation results. Subsequently, INS was administered to the IC of anesthetized mice, and the modulation effect on neural activity was measured using an electrophysiological approach. We found that the modulatory effect of INS on spontaneous neural activity was bidirectional between facilitatory and inhibitory effects. The modulatory effect on sound-evoked responses produced only an inhibitory effect to all examined stimulus intensities. Thus, this study provides important physiological evidence on the response properties of IC neurons to INS. Overall, INS can be used for the development of new therapies for neurological diseases and functional support devices for auditory central processing. Significance statementUsing continuous infrared neural stimulation (INS) of low to high power density, we sought to examine laminar modulation of neural activity in the mouse inferior colliculus (IC) in the presence and absence of sound. We found that the modulatory effect of INS on spontaneous neural activity was bidirectional between facilitatory and inhibitory effects. Additionally, the modulatory effect on sound-evoked responses produced only an inhibitory effect at all examined stimulus intensities. Thus, this study provides important physiological evidence on the response properties of IC neurons to INS. Moreover, INS can be used for the development of new therapies for neurological diseases and functional support devices for auditory central processing.
  • Ryo Furukawa, Shuichi Murakami, Takashi Tateno
    Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies (BIODEVICE 2024) 95 - 102 2024年 [査読有り]
  • Ryo Furukawa, Takahiro Yoshikawa, Shuichi Murakami, Takashi Tateno
    Journal of neuroscience methods 110048 - 110048 2023年12月25日 [査読有り]
     
    BACKGROUND: Ultrasound stimulation is used to noninvasively stimulate the local and deep areas of the brain. However, the detailed cellular mechanisms of neural activation are still unclear because studies on micro-stimulation at the cellular level are lacking. NEW METHOD: To modulate neural activity at the cellular level, we developed a piezoelectric micromachined ultrasound transducer (PMUT), having circular diaphragms for application on acute brain slice preparations. To monitor neural activities, additionally, we fabricated recording microelectrodes onto the same PMUT device for future closed-loop application. RESULTS: To examine the PMUT-driven cellular responses of a brain slice, intracellular calcium signals in individual cells were measured using two calcium indicators. We successfully observed the intracellular responses triggered by the ultrasound of our novel PMUT. In addition, we performed recordings of local field potentials in a brain slice, demonstrating its usefulness as a simultaneous recording interface. COMPARISON WITH EXISTING METHOD(S): Conventional ultrasound stimulators are open-loop systems that risk inducing excessive neural activity because of the absence of neural activity monitoring. In contrast, our PMUT is packaged in a single device with both stimulation and sensor interface for neuromodulation. Further, there are no published reports on in vitro microdevices that can be used for ultrasound stimulation in rodent cortical slices that are several hundred micrometers thick, which maintain the cortical laminar structure and intrinsic neural networks. CONCLUSIONS: Our findings suggest that this novel PMUT device has the potential for being a powerful tool for in vitro brain slice applications and effective closed loop ultrasound stimulation.
  • Takahiro Yoshikawa, Hiromu Sato, Koki Kawakatsu, Takashi Tateno
    Journal of Visualized Experiments 195 2023年05月26日 [査読有り]
  • Takahiro Yoshikawa, Hisaya Higuchi, Ryo Furukawa, Takashi Tateno
    Brain Research 1796 148092 - 148092 2022年12月 [査読有り]
  • Ryo Furukawa, Hiroki Kaneta, Takashi Tateno
    Frontiers in Neuroscience 16 2022年02月22日 [査読有り]
     
    Ultrasound stimulation is expected to be useful for transcranial local and deep stimulation of the brain, which is difficult to achieve using conventional electromagnetic stimulation methods. Previous ultrasound stimulation experiments have used various types of acute in vitro preparations, including hippocampus slices from rodents and Caenorhabditis elegans tissue. For in vivo preparations, researchers have used the cortices of rodents as targets for transcranial ultrasound stimulation. However, no previous studies have used in vitro ultrasound stimulation in rodent cortical slices to examine the mechanisms of ultrasound-driven central neural circuits. Here we demonstrate the optimal experimental conditions for an in vitro ultrasound stimulation system for measuring activity in brain slices using a multielectrode array substrate. We found that the peak amplitudes of the ultrasound-evoked cortical responses in the brain slices depend on the intensities and durations of the ultrasound stimulation parameters. Thus, our findings provide a new in vitro experimental setup that enables activation of a brain slice via ultrasound stimulation. Accordingly, our results indicate that choosing the appropriate ultrasound waveguide structure and stimulation parameters is important for producing the desired intensity distribution in a localized area within a brain slice. We expect that this experimental setup will facilitate future exploration of the mechanisms of ultrasound-driven neural activity.
  • Ryo Furukawa, Takashi Tateno
    Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies 1 196 - 203 2022年 [査読有り][通常論文]
  • Hisaya Higuchi, Ryo Furukawa, Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 16 7 1035 - 1037 2021年07月 [査読有り]
     
    Transcranial magnetic stimulation (TMS) is used for neuromodulation of the human brain. However, the technique is not widely used for small animal models. Here, we propose millimeter-sized coils for brain stimulation of small animals. To estimate the electric field distributions of TMS coils, we performed magnetic flux density measurements and computer simulation using a simplified model combining a mouse head and a TMS coil. Our results indicate the millimeter-sized TMS coils produce electrical field with sufficient magnitude to activate the cortex under the skull in vivo. (C) 2021 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
  • Takumi Kuwano, Hiroki Kaneta, Jun Nishikawa, Kazuo Satoh, Shuichi Murakami, Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 15 12 1816 - 1823 2020年12月 [査読有り]
     
    We have developed a piezoelectric acoustic sensor that responds to rodents' audible frequency range as a front-end device for a small hearing prosthesis system appropriate for animal experiments. The proposed piezoelectric transducer uses a biomimetic hearing mechanism that mimics bandpass-filtering functions realized biologically in the cochlear membranes and hair cells of rodents via a frequency-selective piezoelectric cantilever beam array that will be used to stimulate auditory neurons in future applications to humans. First, to examine the frequency selectivity and response sensitivity, a piezoelectric acoustic transducer having a cantilever array structure with multiple beams were designed, and the mechanical resonance properties of the sensor-device structure were analyzed using a numerical calculation method. Next, on the basis of the numerical results, we proposed a practical acoustic sensor design and sensor construction method using a multiple cantilever array structure and piezoelectric material. We built the sensor using standard microfabrication techniques and evaluated its piezoelectric properties in terms of sound sensitivity. Finally, we addressed future applications of an integrated system containing the proposed acoustic sensor, which could be combined with an electrical stimulation system and used as an auditory prosthesis system to compensate hearing losses in rodent models with hearing disorders and diseases. (c) 2020 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
  • Shunsuke Sugai, Hisaya Higuchi, Jun Nishikawa, Kazuo Satoh, Shuichi Murakami, Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 15 11 1672 - 1680 2020年11月 [査読有り]
     
    Magnetic stimulation is widely used as a medical treatment for neurological diseases. A reduction in the size of magnetic stimulation devices is desirable, however, because the coils are relatively large compared with electrode stimulation devices. Furthermore, in transcranial magnetic stimulation, the exact magnetically evoked areas in the brain and the mechanisms of neural activation are largely unknown. This study aimed to develop a new implantable microcoil device that stimulates the brain locally, on the order of several tens of micrometers, as well as to understand the mechanisms of micromagnetic stimulation-induced neural activity. First, to investigate the effects of microcoil shape on neural activation, the induced electric fields of semicircular microcoils with different diameters were calculated numerically in a microcoil model using the standard finite element method. Next, on the basis of the obtained numerical results from the microcoil model with different diameters, we compared the spatial properties of the possible activated areas in neural tissue and examined the most effective microcoil shape for neural activation. Finally, we measured microcoil-evoked responses using autofluorescent flavoprotein imaging of the mouse brainin vivo, evaluated the validity of our proposed microcoil devices, and discussed possible future improvements for a chronic implant. (c) 2020 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
  • Masato Toda, Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 15 8 1246 - 1247 2020年08月 [査読有り]
     
    Ultrasound stimulation is expected to be capable of transcranial deep and local stimulation to the brain, which is difficult to achieve using conventional electromagnetic stimulation. Once an ultrasound transducer is determined, however, its physical characteristics are hard to change. For obtaining the appropriate irradiation properties, we used a computer simulation of our experimental setup to characterize the optimal shape and size of a waveguide attached to the tip of an ultrasound transducer to target a specific brain region. We obtained an optimal waveguide structure to produce the desired intensity distribution. Our next challenge is to test in our physical setup. (c) 2020 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.
  • Shuto Muramatsu, Masato Toda, Jun Nishikawa, Takashi Tateno
    Brain Research 1721 146312 - 146312 2019年10月 [査読有り]
  • Minusa S, Muramatsu S, Osanai H, Tateno T
    Journal of neural engineering 16 6 066014  2019年10月 [査読有り][通常論文]
  • Takasu K, Tateno T
    Hearing research 377 208 - 223 2019年06月 [査読有り][通常論文]
  • Laminar Responses in the Auditory Cortex Using a Multielectrode Array Substrate for Simultaneous Stimulation and Recording
    Sota Takahashi, Shuto Muramatsu, Jun Nishikawa, Kazuo Satoh, Shuichi Murakami, Takashi Tateno
    2019年01月 [査読有り][通常論文]
  • 総説： 聴覚神経活動動態の計測と制御 ―神経制御工学の展開―
    舘野高
    生物物理 58 3 139 - 143 2018年06月 [査読有り][招待有り]
  • Hisayuki Osanai, Shunsuke Minusa, Takashi Tateno
    Neuroscience 371 346 - 370 2018年02月10日 [査読有り][通常論文]
     
    Magnetic stimulation is widely used in neuroscience research and clinical treatment. Despite recent progress in understanding the neural modulation mechanism of conventional magnetic stimulation methods, the physiological mechanism at the cortical microcircuit level is not well understood due to the poor stimulation focality and large electric artifact in the recording. To overcome these issues, we used a sub-millimeter-sized coil (micro-coil) to stimulate the mouse auditory cortex in vivo. To determine the mechanism, we conducted the first direct electrophysiological recording of micro-coil-driven neural responses at multiple sites on the horizontal surface and laminar areas of the auditory cortex. The laminar responses of local field potentials (LFPs) to the magnetic stimulation reached layer 6, and the spatiotemporal profiles were very similar to those of the acoustic stimulation, suggesting the activation of the same cortical microcircuit. The horizontal LFP responses to the magnetic stimulation were evoked within a millimeter-wide area around the stimulation coil. The activated cortical area was dependent on the coil orientation, providing useful information on the effective position of the coil relative to the brain surface for modulating cortical circuitry activity. In addition, numerical calculation of the induced electric field in the brain revealed that the inhomogeneity of the horizontal electric field to the surface is critical for micro-coil-induced cortical activation. The results suggest that our micro-coil technique has the potential to be used as a chronic, less-invasive and highly focal neuro-stimulator, and is useful for investigating microcircuit responses to magnetic stimulation for clinical treatment.
  • Jun Nishikawa, Yuto Ohtaka, Yuishi Tachibana, Yasutaka Yanagawa, Hisayuki Osanai, Takeaki Haga, Takashi Tateno
    Journal of Neuroscience Methods 293 77 - 85 2018年01月01日 [査読有り][通常論文]
     
    Background Chronic neural recording in freely moving animals is important for understanding neural activities of cortical neurons associated with various behavioral contexts. In small animals such as mice, it has been difficult to implant recording electrodes into exact locations according to stereotactic coordinates, skull geometry, or the shape of blood vessels. The main reason for this difficulty is large individual differences in the exact location of the targeted brain area. New methods We propose a new electrode implantation procedure that is combined with transcranial flavoprotein fluorescence imaging. We demonstrate the effectiveness of this method in the auditory cortex (AC) of mice. Results Prior to electrode implantation, we executed transcranial flavoprotein fluorescence imaging in anesthetized mice and identified the exact location of AC subfields through the skull in each animal. Next, we surgically implanted a microdrive with a tungsten electrode into exactly the identified location. Finally, we recorded neural activity in freely moving conditions and evaluated the success rate of recording auditory responses. Comparison with existing method(s) These procedures dramatically improved the success rate of recording auditory responses from 21.1% without imaging to 100.0% with imaging. We also identified large individual differences in positional relationships between sound-driven response areas and the squamosal suture or blood vessels. Conclusions Combining chronic electrophysiology with transcranial flavoprotein fluorescence imaging before implantation enables the realization of reliable subfield-targeted neural recording from freely moving small animals.
  • Minoru Namikawa, Ayaka Sano, Takashi Tateno
    FRONTIERS IN AGING NEUROSCIENCE 9 395  2017年12月 [査読有り][通常論文]
     
    The prevalence of tinnitus is known to increase with age. The age-dependent mechanisms of tinnitus may have important implications for the development of new therapeutic treatments. High doses of salicylate can be used experimentally to induce transient tinnitus and hearing loss. Although accumulating evidence indicates that salicylate induces tinnitus by directly targeting neurons in the peripheral and central auditory systems, the precise effect of salicylate on neural networks in the auditory cortex (AC) is unknown. Here, we examined salicylate-induced changes in stimulus-driven laminar responses of AC slices with salicylate superfusion in young and aged senescence-accelerated-prone (SAMP) and -resistant (SAMR) mice. Of the two strains, SAMP1 is known to be a more suitable model of presbycusis. We recorded stimulus-driven laminar local field potential (LFP) responses at multi sites in AC slice preparations. We found that for all AC slices in the two strains, salicylate always reduced stimulus-driven LFP responses in all layers. However, for the amplitudes of the LFP responses, the two senescence-accelerated mice (SAM) strains showed different laminar properties between the pre-and post-salicylate conditions, reflecting strainrelated differences in local circuits. As for the relationships between auditory brainstem response (ABR) thresholds and the LFP amplitude ratios in the pre-vs. post-salicylate condition, we found negative correlations in layers 2/ 3 and 4 for both older strains, and in layer 5 (L5) in older SAMR1. In contrast, the GABAergic agonist muscimol (MSC) led to positive correlations between ABR thresholds and LFP amplitude ratios in the prevs. post-MSC condition in younger SAM mice from both strains. Further, in younger mice, salicylate decreased the firing rate in AC L4 pyramidal neurons. Thus, salicylate can directly reduce neural excitability of L4 pyramidal neurons and thereby influence AC neural circuit activity. That we observed age-dependent effects of salicylate and varied GABAergic sensitivity in the AC among mouse strains with hearing loss implies that potential therapeutic mechanisms for tinnitus may operate differently in young vs. aged subjects. Therefore, scientists developing new therapeutic modalities for tinnitus treatment should consider using both aged and young animals.
  • Minusa S, Osanai H, Tateno T
    IEEE transactions on bio-medical engineering 65 6 1301 - 1310 2017年09月 [査読有り][通常論文]
     
    Objective: Recent studies have reported that micromagnetic stimulation (mu MS), which can activate neurons and neural networks via submillimeter inductors, may address several limitations of conventional magnetic stimulation methods. Previous studies have examined the effects of mu MS on single neurons, yet little is known about how mu MS can affect brain tissue including local neural networks. Here, we propose a new, readily available implantable mu MS system and computationally and experimentally evaluate its validity. Methods: We conducted numerical calculations and experiments to evaluate the physical characteristics, including magnetic flux density, temperature, coil impedance, and structural integrity of the flexible board supporting the mu MS coils. We then compared sound-and mu MS-driven neural responses in the mouse auditory cortex using flavoprotein autofluorescence imaging. Results: Our system successfully activated neural tissue, and we observed activity propagation in local neural networks on the brain surface beyond restricted activation of single neurons. Examining the relationships between stimulation parameters and response characteristics, we found that stimulation amplitude and pulse width were the two most important parameters to effectively induce neural activity. Conclusion: Our mu MS device has sufficient potential to drive the brain as an implantable magnetic stimulator for basic neuroscience and clinical applications, although further investigation is required. Significance: mu MS can selectively drive and modulate activity in local neural network even at an in vivo tissue level.
  • Yasutaka Yanagawa, Kengo Takasu, Hisayuki Osanai, Takashi Tateno
    HEARING RESEARCH 351 98 - 115 2017年08月 [査読有り][通常論文]
     
    Salicylate is the active ingredient in aspirin, and in high-doses it is used as an experimental tool to induce transient hearing loss, tinnitus, and hyperacusis. These salicylate-induced perceptual disturbances are associated with tonotopic-map reorganization and neural activity modulation, and such neural correlates have been examined in the central auditory pathway, including the auditory cortex (AC). Although previous studies have reported that salicylate induces increases in noise-burst-evoked neural responses and reorganization of tonotopic maps in the primary AC, little is known about the effects of salicylate on other frequency-organized AC subfields such as the anterior auditory, secondary auditory, and dorsomedial fields. Therefore, to examine salicylate-induced spatiotemporal effects on AC subfields, we measured sound-evoked neural activity in mice before and after the administration of sodium salicylate (SS, 200 mg/kg), using flavoprotein auto-fluorescence imaging. SS-treatment gradually reduced responses driven by tone-bursts with lower (<= 8 kHz) and higher (>= 25 kHz) frequencies over 3 h, whereas evoked responses to tone-bursts within middle-range frequencies (e.g., 12 and 16 kHz) were sustained and unchanged in the four subfields. Additionally, in each of the four subfields, SS-treatment induced similar reorganization of tonotopic maps, and the response areas selectively driven by the middle-range frequencies were profoundly expanded. Our results indicate that the SS-induced tonotopic map reorganizations in each of the four AC subfields were similar, and only the extent of the activated areas responsive to tone-bursts with specific frequencies was subfield-dependent. Thus, we expect that examining cortical reorganization induced by SS may open the possibility of new treatments aimed at altering cortical reorganization into the normative functional organization. (C) 2017 Elsevier B.V. All rights reserved.
  • Daiki Yamamura, Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 12 S164 - S170 2017年06月 [査読有り][通常論文]
     
    All sensory cortical areas, including the auditory cortex, are considered to be wired according to the same general laminar structure schema, commonly referred to as the canonical model of cortical circuitry. The auditory cortex in vivo, however, is functionally anisotropic; the functional organization along the tonotopic axis is qualitatively different from that orthogonal to this axis. In the current study, we examined whether the functional anisotropy of the auditory cortex observed in vivo is reflected in propagation activity driven by electric stimulation in the local microcircuitry in vitro. Using in vitro preparations of coronal and angled horizontal brain slices, we directly investigated their isotropic versus anisotropic properties using microstimulation and multi-site recording with a multielectrode array substrate. Our results clearly demonstrated the isotropic properties of the circuits in slice preparations of the auditory cortex. Additionally, we found that driven by stimulation current in layer 4, the horizontal velocity of activity propagation in layer 2/3 was faster than the vertical velocity from layer 4 to layer 2/3 and the horizontal velocity in layer 4. On the basis of these results, we discuss the local network and its possible functions in the auditory cortex. (C) 2017 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
  • Daiki Yamamura, Ayaka Sano, Takashi Tateno
    BRAIN RESEARCH 1659 96 - 112 2017年03月 [査読有り][通常論文]
     
    To examine local network properties of the mouse auditory cortex in vitro, we recorded extracellular spatiotemporal laminar profiles driven by short electric local stimulation on a planar multielectrode array substrate. The recorded local field potentials were subsequently evaluated using current source density (CSD) analysis to identify sources and sinks. Current sinks are thought to be an indicator of net synaptic current in the small volume of cortex surrounding the recording site. Thus, CSD analysis combined with multielectrode arrays enabled us to compare mean synaptic activity in response to small current stimuli on a layer-by-layer basis. We also used senescence-accelerated mice (SAM), some strains of which show earlier onset of age-related hearing loss, to examine the characteristic spatiotemporal CSD profiles stimulated by electrodes in specific cortical layers. Thus, the CSD patterns were classified into several clusters based on stimulation sites in the cortical layers. We also found some differences in CSD patterns between the two SAM strains in terms of aging according to principle component analysis with dimension reduction. For simultaneous two-site stimulation, we modeled the obtained CSD profiles as a linear superposition of the CSD profiles to individual single-site stimulation. The model analysis indicated the nonlinearity of spatiotemporal integration over stimulus-driven activity in a layer-specific manner. Finally, on the basis of these results, we discuss the auditory cortex local network properties and the effects of aging on these mouse strains. (C) 2017 Elsevier B.V. All rights reserved.
  • Yasutaka Yanagawa, Hisayuki Osanai, Takashi Tateno
    NEUROSCIENCE LETTERS 633 189 - 195 2016年10月 [査読有り][通常論文]
     
    The effects of anesthesia on the functional auditory characteristics of cortical neurons, such as spatial and temporal response properties, vary between an anesthetized and an awake subject. However, studies have shown that an appropriate anesthetic method that approaches the awake condition is still useful because of its greater stability and controllability. The present study compared neural response properties from two core fields of the mouse auditory cortex under three anesthetic conditions: urethane; ketamine and xylazine hydrochloride (KX) mixture; and a combination of medetomidine, midazolam, and butorphanol (MMB). To measure sound stimulation in vivo, we recorded flavoprotein-autofluorescent images of endogenous green fluorescence. Under all conditions, fluorescence changes in auditory core subfields in response to tones were observed, and response properties, such as peak intensity, latency, duration, and activated areas were analyzed. Results showed larger response peak intensity, latency, and duration in the core subfields under urethane compared with KX and MMB, with no significant differences between KX and MMB. Conversely, under KX anesthesia the activated areas showed characteristic response properties in a subfield-dependent manner. These results demonstrated the varied effects of anesthesia on response properties in the core subfields of the auditory cortex. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
  • Hisayuki Osanai, Takashi Tateno
    HEARING RESEARCH 339 69 - 79 2016年09月 [査読有り][通常論文]
     
    Anesthesia affects central auditory processing. However, it is unclear to what extent the choice of anesthetic agent affects neural responses to sound stimulation. A mixture of three anesthetics (medetomidine, midazolam and butorphanol; MMB) was recently developed as an alternative to lcetamine owing to the latter's addictive potential, yet the effect of this combination of anesthetics on neural responses is not known. Here, we compared the spontaneous activity, tuning properties and temporal responses of primary auditory cortical neurons under these two anesthetic conditions, using electro-physiological and flavoprotein autofluorescence imaging methods. Frequency tuning properties were not significantly different between ketamine and MMB anesthesia. However, neural activity under MMB showed decreases in the spontaneous and tone-evoked firing rates in a layer-dependent manner. Moreover, the temporal response patterns were also different between the anesthetics in a layer dependent manner, which may reflect differences in the anesthetic mechanisms. These results demonstrated how response properties in the primary auditory cortex are affected by the choice of anesthesia. (C) 2016 Elsevier B.V. All rights reserved.
  • Noto M, Nishikawa J, Tateno T
    Neuroscience 318 58 - 83 2016年03月 [査読有り][通常論文]
  • Osanai, Hisayuki, Tateno, Takashi
    NEURAL INFORMATION PROCESSING, ICONIP 2016, PT II 9948 363 - 371 2016年 [査読有り][通常論文]
     
    Neural oscillations are considered to reflect the activity of neural populations, and are thus closely associated with brain function. However, the extent to which different anesthetic agents exert unique effects on such oscillations is unclear. A mixture of three anesthetics (medetomidine, midazolam, and butorphanol) was recently developed as an alternative to ketamine, which has potential addictive effects. Yet, little is known about the effects of this combination of anesthetics on neural oscillations. In this study, we used multi-channel electro-physiological recording and flavoprotein endogenous imaging to compare sound-driven oscillations in primary auditory cortical neurons after administration of ketamine vs. a medetomidine, midazolam, and butorphanol mixture. We observed differences in high gamma activities (over 120 Hz) between these two anesthetics, independent of cortical layers, but found no differences in activities including lower frequency components (<120 Hz). Our results provide new information about how specific anesthetics influence sound-driven neural oscillations.
  • Shunsuke Minusa, Takashi Tateno
    NEURAL INFORMATION PROCESSING, ICONIP 2016, PT II 9948 372 - 380 2016年 [査読有り][通常論文]
     
    Although electromagnetic stimulation is widely used in neurological studies and clinical applications, conventional electromagnetic stimulation methods have several limitations. Recent studies have reported that micro magnetic stimulation (mu MS), which can directly activate neural tissue and cells via sub-millimeter solenoids, has the possibility to overcome such limitations. However, the development and application of mu MS using implantable sub-millimeter solenoids has not yet been reported. Here, we proposed a new implantable mu MS system and evaluated its validity. In particular, using flavoprotein fluorescence imaging with a high spatial resolution, we evaluated if the stimuli delivered by our system were large enough to activate the mouse auditory cortex in vivo. The results indicated that our system successfully activated neural tissue, and the activity propagation was observed on the brain surface. Thus, this study is the first step to applying mu MS implantable devices in investigating basic neuroscience and clinical application tools.
  • Daiki Yamamura, Sano Ayaka, Takashi Tateno
    NEURAL INFORMATION PROCESSING, ICONIP 2016, PT II 9948 353 - 362 2016年 [査読有り][通常論文]
     
    To examine microcircuit properties of the mouse auditory cortex (AC) in vitro, we extracellularly recorded spatiotemporal laminar profiles driven by short electric microstimulation on a planar multielectrode array (MEA) substrate. The recorded local field potentials (LFPs) were subsequently evaluated using current source density (CSD) analysis to identify sources and sinks. Current sinks are thought to be an indicator of net synaptic current in a small volume of cortex surrounding the recording site. Thus, CSD analysis combined with MEAs enabled us to compare mean synaptic activity in response to current stimuli on a layer-bylayer basis. Here, we used senescence-accelerated mice (SAM), some strains of which show age-related hearing loss, to examine characteristic spatiotemporal CSD patterns stimulated by electrodes in specific cortical layers. Thus, the CSD patterns were classified into several clusters based on the stimulation sites in the cortical layers. We also found, in a reduced space obtained by principle component analysis, some CSD pattern differences between the two SAM strains in terms of aging and stimulation layers. Finally, on the basis of these results, we discuss the effects of aging on AC microcircuit properties.
  • Takashi Tateno, Jun Nishikawa
    Frontiers in Neuroengineering 7 39  2014年10月10日 [査読有り][通常論文]
     
    In this report, we describe the system integration of a complementary metal oxide semiconductor (CMOS) integrated circuit (IC) chip, capable of both stimulation and recording of neurons or neural tissues, to investigate electrical signal propagation within cellular networks in vitro. The overall system consisted of three major subunits: a 5.0 × 5.0 mm CMOS IC chip, a reconfigurable logic device (field-programmable gate array, FPGA), and a PC. To test the system, microelectrode arrays (MEAs) were used to extracellularly measure the activity of cultured rat cortical neurons and mouse cortical slices. The MEA had 64 bidirectional (stimulation and recording) electrodes. In addition, the CMOS IC chip was equipped with dedicated analog filters, amplification stages, and a stimulation buffer. Signals from the electrodes were sampled at 15.6 kHz with 16-bit resolution. The measured input-referred circuitry noise was 10.1 μ V root mean square (10 Hz to 100 kHz), which allowed reliable detection of neural signals ranging from several millivolts down to approximately 33 μ Vpp. Experiments were performed involving the stimulation of neurons with several spatiotemporal patterns and the recording of the triggered activity. An advantage over current MEAs, as demonstrated by our experiments, includes the ability to stimulate (voltage stimulation, 5-bit resolution) spatiotemporal patterns in arbitrary subsets of electrodes. Furthermore, the fast stimulation reset mechanism allowed us to record neuronal signals from a stimulating electrode around 3 ms after stimulation. We demonstrate that the system can be directly applied to, for example, auditory neural prostheses in conjunction with an acoustic sensor and a sound processing system.
  • Takashi Tateno, Jun Nishikawa, Nobuyoshi Tsuchioka, Hirofumi Shintaku, Satoyuki Kawano
    Frontiers in neuroengineering 6 12 - 12 2013年 [査読有り][通常論文]
     
    To improve the performance of cochlear implants, we have integrated a microdevice into a model of the auditory periphery with the goal of creating a microprocessor. We constructed an artificial peripheral auditory system using a hybrid model in which polyvinylidene difluoride was used as a piezoelectric sensor to convert mechanical stimuli into electric signals. To produce frequency selectivity, the slit on a stainless steel base plate was designed such that the local resonance frequency of the membrane over the slit reflected the transfer function. In the acoustic sensor, electric signals were generated based on the piezoelectric effect from local stress in the membrane. The electrodes on the resonating plate produced relatively large electric output signals. The signals were fed into a computer model that mimicked some functions of inner hair cells, inner hair cell-auditory nerve synapses, and auditory nerve fibers. In general, the responses of the model to pure-tone burst and complex stimuli accurately represented the discharge rates of high-spontaneous-rate auditory nerve fibers across a range of frequencies greater than 1 kHz and middle to high sound pressure levels. Thus, the model provides a tool to understand information processing in the peripheral auditory system and a basic design for connecting artificial acoustic sensors to the peripheral auditory nervous system. Finally, we discuss the need for stimulus control with an appropriate model of the auditory periphery based on auditory brainstem responses that were electrically evoked by different temporal pulse patterns with the same pulse number.
  • Ryouhei Iwahashi, Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 7 S71 - S76 2012年12月 [査読有り][通常論文]
     
    Concentrations of free intracellular calcium ions ([Ca2+]i) in excitable cells are often measured using indicator dyes, such as fura-2. Of note, however, these indicator dyes are divalent metal ion chelators that affect intrinsic changes in [Ca2+]i. To examine whether indicator dyes alter calcium signaling, we estimated [Ca2+]i using a novel statistical inference method that examines fluorescence signals and the calcium current through the cell membrane. We first constructed a model of transient [Ca2+]i, which was then translated into a state-space model with such state variables as [Ca2+]i, endogenous calcium buffer, and calcium indicators. Then, a self-organizing state-space model was defined by augmenting a state vector with unknown parameters from the original state-space model. In the model, some unknown parameters were estimated with the original state vector. Next, we used a recursive Bayesian estimation to obtain a set of state vectors and the unknown parameters associated with a set of observation vectors. To calculate the recursive Bayesian estimation, we used a sequential Monte Carlo method, which is referred to as a particle filter method. To verify the effectiveness of the proposed method, we carried out experiments with a set of test data from a model with known parameters. The results show that our proposed method properly estimated the temporal profiles of [Ca2+]i, the indicator dye concentration, and certain model parameters in a noisy environment. (c) 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
  • Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 7 3 283 - 290 2012年05月 [査読有り][通常論文]
     
    To examine the functional role of hyperpolarization-activated and cyclic nucleotide-gated (HCN) current observed in mesencephalic dopaminergic neurons, we constructed a conductance-based model that can mimic the electrical properties obtained in electrophysiological recordings of rat brain slices. In the model, blocking the HCN current resulted in a reduction of spontaneous firing rate and a change in the properties of autonomous pacemaking. In addition, reduced one-dimensional phase equations and their coupled oscillators were analyzed. The analysis indicated that HCN channels can regulate the extent of synchronization of coupled dopaminergic neurons through gapjunction connections. Thus, the HCN current can effectively shape the autonomous and cooperative firing of dopaminergic neurons in the midbrain. (C) 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
  • Simple dynamical models to understand the mechanisms of drug addiction
    舘野高
    Advances in Cognitive Neurodynamics III 2012年 [査読有り][通常論文]
  • Hugo Zeberg, Nathan W. Gouwens, Kunichika Tsumoto, Takashi Tateno, Kazuyuki Aihara, Hugh P.C. Robinson
    Phase Response Curves in Neuroscience: Theory, Experiment, and Analysis 489 - 509 2012年01月01日 [査読有り][通常論文]
     
    Synchronous firing of cortical fast-spiking (FS) interneurons is important in generating gamma frequency (30-80 Hz) oscillations. These cells connect with each other, both through inhibitory chemical synapses and through gap junctions. To understand how these synaptic interactions control synchronization, we injected artificial synaptic conductances in FS cells, and measured the phase resetting produced by synaptic inputs, the synaptic phase-resetting function (SPRF), during gamma-frequency firing. We found that artificial GABAA receptor and gap junctional conductances made distinct contributions to the SPRF, which had a remarkably simple, piecewise linear form, with a sharp break between regions of phase delay and advance. Analysing the SPRF shows how the intrinsic properties of FS neurons and their synaptic connections allow synchronization of firing over a wide gamma frequency band, and upper and lower frequency limits of this band are shown to be controlled by gap junctions and GABAergic inhibition, respectively. This phase-resetting model gives insight into how FS cells synchronize so effectively at gamma oscillations, and can be a building block in large-scale simulations of the FS cell networks, in order to understand the onset and stability of patterns of gamma oscillation in the cortex.
  • Takashi Tateno, Hugh P. C. Robinson
    JOURNAL OF NEUROPHYSIOLOGY 106 4 1901 - 1922 2011年10月 [査読有り][通常論文]
     
    Tateno T, Robinson HP. The mechanism of ethanol action on midbrain dopaminergic neuron firing: a dynamic-clamp study of the role of I h and GABAergic synaptic integration. J Neurophysiol 106: 1901-1922, 2011. First published June 22, 2011; doi:10.1152/jn.00162.2011.-Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are expressed in dopaminergic (DA) neurons of the ventral tegmental area (VTA) as well as in DA and GABAergic neurons of the substantia nigra (SN). The excitation of DA neurons induced by ethanol has been proposed to result from its enhancing HCN channel current, I h. Using perforated patch-clamp recordings in rat midbrain slices, we isolated I h in these neurons by voltage clamp. We showed that ethanol reversibly increased the amplitude and accelerated the activation kinetics of I h and caused a depolarizing shift in its voltage dependence. Using dynamic-clamp conductance injection, we injected artificial I h and fluctuating GABAergic synaptic conductance inputs into neurons following block of intrinsic I h. This demonstrated directly a major role of I h in promoting rebound spiking following phasic inhibition, which was enhanced as the kinetics and amplitude of I h were changed in the manner induced by ethanol. Similar effects of ethanol were observed on I h and firing rate in non-DA, putatively GABAergic interneurons, indicating that in addition to its direct effects on firing, ethanol will produce large changes in the inhibition and disinhibition (via GABAergic interneurons) converging on DA neurons. Thus the overall effects of ethanol on firing of DA cells of the VTA and SN in vivo, and hence on phasic dopamine release in the striatum, appear to be determined substantially by its action on I h in both DA cells and GABAergic interneurons.
  • 舘野高
    IEE Japan Transactions on Electronics, Information and Systems 131 1 5 - 55 2011年 [査読有り][通常論文]
     
    In this study, I aim to understand morphological changes in dopaminergic neurons of the rat midbrain during early developmental stages and their computational properties in the dendrites. To this end, firstly, I measured morphological details of dopaminergic neurons using an immunochemical double-staining technique. In the viewpoint of the Rail's equivalent-cylinder model, secondly, I tested if the data satisfied one of conditions (3/2 power law) of the Rail's model. On the basis of the experimental data, I next investigated if some branches in the individual dendrites had special selectivity in efficient passive propagation of membrane potentials between the branches of individual cells and different cells. The results show that the Rail's 3/2 power law was not satisfied in many branch points and that among branches of each dendrite, specific selectivity in efficient propagation was not found. In addition, I note an implementation method in which the finite element method is applied to one-dimensional cable model of dendrites and give some numerical examples. © 2011 The Institute of Electrical Engineers of Japan.
  • Nathan W. Gouwens, Hugo Zeberg, Kunichika Tsumoto, Takashi Tateno, Kazuyuki Aihara, Hugh P.C. Robinson
    PLoS Computational Biology 6 9 1 - 13 2010年09月 [査読有り][通常論文]
     
    Fast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic interactions control synchronization, artificial synaptic conductances were injected in FS cells, and the synaptic phase-resetting function (SPRF), describing how the compound synaptic input perturbs the phase of gamma-frequency spiking as a function of the phase at which it is applied, was measured. GABAergic and gap junctional conductances made distinct contributions to the SPRF, which had a surprisingly simple piecewise linear form, with a sharp midcycle break between phase delay and advance. Analysis of the SPRF showed how the intrinsic biophysical properties of FS neurons and their interconnections allow entrainment of firing over a wide gamma frequency band, whose upper and lower frequency limits are controlled by electrical synapses and GABAergic inhibition respectively. © 2010 Gouwens et al.
  • Takashi Tateno
    NEUROREPORT 21 10 667 - 674 2010年07月 [査読有り][通常論文]
     
    To analyze the small-conductance calcium-dependent K+ current observed in dopaminergic neurons of the rat midbrain, we have developed a new dynamic current clamping method that incorporates recording of intracellular Ca2+ levels. As reported earlier, blocking the small-conductance current with apamin shifted the firing modes of dopaminergic neurons and changed the firing rate and spike afterhyperpolarization. We modeled the kinetic properties of the current and assessed the model in a real-time computational system. Here, we show that the spike afterhyperpolarization is regulated by the small-conductance current, an effect that is observed in dopaminergic neurons. Thus, this current can effectively shape the autonomous firing patterns of dopaminergic neurons. NeuroReport 21:667-674 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
  • Hirofumi Shintaku, Takashi Tateno, Nobuyoshi Tsuchioka, Harto Tanujaya, Takayuki Nakagawa, Juichi Ito, Satoyuki Kawano
    Journal of Biomechanical Science and Engineering 5 3 229 - 235 2010年 [査読有り][通常論文]
     
    In this paper, we report an in vitro study on the biocompatibility of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) films for the implantable artificial cochlea. The implantable artificial cochlea comprises a piezoelectric membrane made of P(VDF-TrFE), platinum (Pt) thin film electrodes, and a silicon substrate which are designed to stimulate neurons in a cochlea and fabricated by microelectromechanical systems (MEMS) and thin film technologies. The biocompatibility of P(VDF-TrFE) film is evaluated by culturing cerebral cortical neurons from rats on it. The fibronectin from human plasma and the collagen from the calf skin are used as the cell adhesion factors. Since neurons extend dendrites and axons from the somata, it is found that the neurons are successfully cultured on the surface of P(VDF-TrFE) films modified both by the fibronectin and by the collagen. Furthermore, it is also found that the neurons are also successfully cultured over the Pt electrode on the P(VDF-TrFE) of the implantable artificial cochlea modified by the fibronectin. Consequently, the biocompatibility and the applicability of the MEMS fabricated P(VDF-TrFE) films and the implantable artificial cochlea are confirmed. © 2010 by JSME.
  • T. Tateno, H.P.C. Robinson
    Journal of Neurophysiology 101 2 1056 - 1072 2009年02月 [査読有り][通常論文]
     
    Tateno T, Robinson HPC. Integration of broadband conductance input in rat somatosensory cortical inhibitory interneurons: an inhibition-controlled switch between intrinsic and input-driven spiking in fast-spiking cells. J Neurophysiol 101: 1056-1072, 2009. First published December 17, 2008; doi: 10.1152/jn.91057.2008. Quantitative understanding of the dynamics of particular cell types when responding to complex, natural inputs is an important prerequisite for understanding the operation of the cortical network. Different types of inhibitory neurons are connected by electrical synapses to nearby neurons of the same type, enabling the formation of synchronized assemblies of neurons with distinct dynamical behaviors. Under what conditions is spike timing in such cells determined by their intrinsic dynamics and when is it driven by the timing of external input? In this study, we have addressed this question using a systematic approach to characterizing the input-output relationships of three types of cortical interneurons (fast spiking [FS], low-threshold spiking [LTS], and nonpyramidal regular-spiking [NPRS] cells) in the rat somatosensory cortex, during fluctuating conductance input designed to mimic natural complex activity. We measured the shape of average conductance input trajectories preceding spikes and fitted a two-component linear model of neuronal responses, which included an autoregressive term from its own output, to gain insight into the input-output relationships of neurons. This clearly separated the contributions of stimulus and discharge history, in a cell-type dependent manner. Unlike LTS and NPRS cells, FS cells showed a remarkable switch in dynamics, from intrinsically driven spike timing to input-fluctuation-controlled spike timing, with the addition of even a small amount of inhibitory conductance. Such a switch could play a pivotal role in the function of FS cells in organizing coherent gamma oscillations in the local cortical network. Using both pharmacological perturbations and modeling, we show how this property is a consequence of the particular complement of voltage-dependent conductances in these cells.
  • T. Tateno, H. P. C. Robinson
    BIOSYSTEMS 89 1-3 110 - 116 2007年05月 [査読有り][通常論文]
     
    Population oscillations in neural activity in the gamma (>30 Hz) and higher frequency ranges are found over wide areas of the mammalian cortex. Recently, in the somatosensory cortex, the details of neural connections formed by several types of GABAergic interneurons have become apparent, and they are believed to play a significant role in generating these oscillations through synaptic and gap-junctional interactions. However, little is known about the mechanism of how such oscillations are maintained stably by particular interneurons and by their local networks, in a noisy environment with abundant synaptic inputs. To obtain more insight into this, we studied a fast-spiking (FS)-cell model including Kv3-channel-like current, which is a distinctive feature of these cells, from the viewpoint of nonlinear dynamical systems. To examine the specific role of the Kv3-channel in determining oscillation properties, we analyzed basic properties of the FS-cell model, such as the bifurcation structure and phase resetting curves (PRCs). Furthermore, to quantitatively characterize the oscillation stability under noisy fluctuations mimicking small fast synaptic inputs, we applied a recently developed method from random dynamical system theory to estimate Lyapunov exponents, both for the original four-dimensional dynamics and for a reduced one-dimensional phase-equation on the circle. The results indicated that the presence of the Kv3-channel-like current helps to regulate the stability of noisy neural oscillations and a trans ient-peri od length to stochastic attractors. (C) 2007 Published by Elsevier Ireland Ltd.
  • T. Tateno, H. P. C. Robinson
    BIOPHYSICAL JOURNAL 92 2 683 - 695 2007年01月 [査読有り][通常論文]
     
    Synchronous oscillations in neural activity are found over wide areas of the cortex. Specific populations of interneurons are believed to play a significant role in generating these synchronized oscillations through mutual synaptic and gap-junctional interactions. Little is known, though, about the mechanism of how oscillations are maintained stably by particular types of interneurons and by their local networks. To obtain more insight into this, we measured membrane-potential responses to small current-pulse perturbations during regular firing, to construct phase resetting curves (PRCs) for three types of interneurons: nonpyramidal regular-spiking (NPRS), low-threshold spiking (LTS), and fast-spiking (FS) cells. Within each cell type, both monophasic and biphasic PRCs were observed, but the proportions and sensitivities to perturbation amplitude were clearly correlated to cell type. We then analyzed the experimentally measured PRCs to predict oscillation stability, or. ring reliability, of cells for a complex stochastic input, as occurs in vivo. To do this, we used a method from random dynamical system theory to estimate Lyapunov exponents of the simplified phase model on the circle. The results indicated that LTS and NPRS cells have greater oscillatory stability ( are more reliably entrained) in small noisy inputs than FS cells, which is consistent with their distinct types of threshold dynamics.
  • Takashi Tateno
    NEUROSCIENCE RESEARCH 58 S186 - S186 2007年 [査読有り][通常論文]
  • Takashi Tateno
    Complex Medical Engineering 565 - 572 2007年 [査読有り][通常論文]
     
    Neurons and dynamical models of spike generation display two different classes of threshold behavior, with steady current stimulation: type 1 and type 2. The dynamics at threshold could have profound effects on the encoding of input as spikes, the sensitivity of spike generation to noisy input, and the coherence of population firing. To comprehend the consequences of spike timing variability during more natural fluctuating input, we compared the postsynaptic firing variability of type-1 regular-spiking pyramidal cells and type-2 fast-spiking interneurons, applying a conductance injection method to rat acute slice preparations in vitro. Using two statistics, the reliability of spike occurrence and the spike jitter, we studied the sensitivity of firing variability to the rate of independent, shunting inhibition and to the correlation in time of synthesized synaptic inputs. The results indicate that differences between the two cell types are consistent with a role of regular-spiking neurons as rate-coding integrators, and a role of fast-spiking neurons as resonators controlling the coherence of synchronous firing.
  • T Tateno, HPC Robinson
    JOURNAL OF NEUROPHYSIOLOGY 95 4 2650 - 2663 2006年04月 [査読有り][通常論文]
     
    Neurons and dynamical models of spike generation display two different classes of threshold behavior: type 1 [firing frequency vs. current (f-I) relationship is continuous at threshold] and type 2 (discontinuous f-I). With steady current or conductance stimulation, regular-spiking (RS) pyramidal neurons and fast-spiking (FS) inhibitory interneurons in layer 2/3 of somatosensory cortex exhibit type 1 and type 2 threshold behaviors, respectively. We compared the postsynaptic firing variability of type 1 RS and type 2 FS cells, during naturalistic, fluctuating conductance input. In RS neurons, increasing the level of independently random, shunting inhibition caused a monotonic increase in spike reliability, whereas in FS interneurons, there was an optimum level of shunting inhibition for achieving the most reliable spike generation and the most precise spike-time encoding. This was observed over a range of different degrees of synchrony, or correlation, in the input. RS cells displayed a progressive rise in spike jitter during natural-like transient burst inputs, whereas for FS cells, jitter was mostly kept low. Furthermore, RS cells showed encoding of the input level in the spike shape, whereas FS cells did not. These differences between the two cell types are consistent with a role of RS neurons as rate-coding integrators, and a role of FS neurons as resonators controlling the coherence of synchronous firing.
  • T Tateno, Y Jimbo, HPC Robinson
    NEUROSCIENCE 134 2 439 - 448 2005年 [査読有り][通常論文]
     
    We studied the effects of carbachol, a cholinergic agonist, on extracellularly evoked firing of networks in mature cultures of rat cortical neurons, using multi-electrode arrays to monitor the activity of large numbers of neurons simultaneously. These cultures show evoked burst firing which propagates through dense synaptic connections. When a brief voltage pulse was applied to one extracellular electrode, spiking electrical responses were evoked in neurons throughout the network. The response had two components: an early phase, terminating within 30-80 ms, and a late phase which could last several hundreds of milliseconds. Action potentials evoked during the early phase were precisely timed, with only small jitter. In contrast, the late phase characteristically showed clusters of electrical activity with significant spatio-temporal fluctuations. The late phase was suppressed by applying a relatively small amount of carbachol (5 mu M) in the external solution, even though the spontaneous firing rate was not significantly changed. Carbachol increased both the spike-timing precision and the speed of propagation of population spikes, and selectively increased the firing coincidence in a subset of neuron pairs in the network, while suppressing late variable firing in responses. Hence, the results give quantitative support for the idea that cholinergic activation in the cortex has a general role of focusing or enhancing significant associative firing of neurons. (c) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.
  • T Tateno, Y Jimbo, HPC Robinson
    NEUROSCIENCE 134 2 425 - 437 2005年 [査読有り][通常論文]
     
    Activation of the cholinergic innervation of the cortex has been implicated in sensory processing, learning, and memory. At the cellular level, acetylcholine both increases excitability and depresses synaptic transmission, and its effects on network firing are hard to predict. We studied the effects of carbachol, a cholinergic agonist, on network firing in cultures of rat cortical neurons, using electrode arrays to monitor the activity of large numbers of neurons simultaneously. These cultures show stable spontaneous synchronized burst firing which propagates through dense synaptic connections. Carbachol (10-50 mu M), acting through muscarinic receptors, was found to induce a switch to asynchronous single-spike firing and to result in a loss of regularity and fragmentation of the burst structure. To obtain a quantitative measure of cholinergic actions on cortical networks, we applied a cluster Poisson-process model to sets of paralleled spike-trains in the presence and absence of carbachol. This revealed that the time series can be well-characterized by such a simple model, consistent with the observed 1/f(b)-like spectra (0.04 < b < 2.08). After applying higher concentrations of carbachol the property of the spectra shifted toward a Poisson-process (white) spectrum. These results indicate that cholinergic neurotransmitters have a strong and reliable desynchronizing action on cortical neural activity. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.
  • T Tateno, A Harsch, HPC Robinson
    JOURNAL OF NEUROPHYSIOLOGY 92 4 2283 - 2294 2004年10月 [査読有り][通常論文]
     
    Neurons and dynamical models of spike generation display two different types of threshold behavior, with steady current stimulation: type 1 [the firing frequency vs. current (f-I) relationship is continuous at threshold) and type 2 (discontinuous f-I)]. The dynamics at threshold can have profound effects on the encoding of input as spikes, the sensitivity of spike generation to input noise, and the coherence of population firing. We have examined the f-I and frequency-conductance (f-g) relationships of cells in layer 2/3 of slices of young (15-21 DIV) rat somatosensory cortex, focusing in detail on the nature of the threshold. Using white-noise stimulation, we also measured firing frequency and inter-spike interval variability as a function of noise amplitude. Regular-spiking (RS) pyramidal neurons show a type 1 threshold, consistent with their well-known ability to fire regularly at very low frequencies. In fast-spiking (FS) inhibitory interneurons, although regular firing is supported over a wide range of frequencies, there is a clear discontinuity in their f-I relationship at threshold (type 2), which has not previously been highlighted. FS neurons are unable to support maintained periodic firing below a critical frequency f(c), in the range of 10 to 30 Hz. Very close to threshold, FS cells switch irregularly between bursts of periodic firing and subthreshold oscillations. These characteristics mean that the dynamics of RS neurons are well suited to encoding inputs into low-frequency firing rates, whereas the dynamics of FS neurons are suited to maintaining and quickly synchronizing to gamma and higher-frequency input.
  • T Tateno, K Pakdaman
    CHAOS 14 3 511 - 530 2004年09月 [査読有り][通常論文]
     
    Determining the response characteristics of neurons to fluctuating noise-like inputs similar to realistic stimuli is essential for understanding neuronal coding. This study addresses this issue by providing a random dynamical system analysis of the Morris-Lecar neural model driven by a white Gaussian noise current. Depending on parameter selections, the deterministic Morris-Lecar model can be considered as a canonical prototype for widely encountered classes of neuronal membranes, referred to as class I and class II membranes. In both the transitions from excitable to oscillating regimes are associated with different bifurcation scenarios. This work examines how random perturbations affect these two bifurcation scenarios. It is first numerically shown that the Morris-Lecar model driven by white Gaussian noise current tends to have a unique stationary distribution in the phase space. Numerical evaluations also reveal quantitative and qualitative changes in this distribution in the vicinity of the bifurcations of the deterministic system. However, these changes notwithstanding, our numerical simulations show that the Lyapunov exponents of the system remain negative in these parameter regions, indicating that no dynamical stochastic bifurcations take place. Moreover, our numerical simulations confirm that, regardless of the asymptotic dynamics of the deterministic system, the random Morris-Lecar model stabilizes at a unique stationary stochastic process. In terms of random dynamical system theory, our analysis shows that additive noise destroys the above-mentioned bifurcation sequences that characterize class I and class II regimes in the Morris-Lecar model. The interpretation of this result in terms of neuronal coding is that, despite the differences in the deterministic dynamics of class I and class II membranes, their responses to noise-like stimuli present a reliable feature. (C) 2004 American Institute of Physics.
  • T Tateno, Y Jimbo, HPC Robinson
    2004 IEEE INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS, VOLS 1-4, PROCEEDINGS 3213 - 3218 2004年 [査読有り][通常論文]
     
    We investigated cholinergic modulation effects on synchronized burst activity of neurons in rat dissociated cortical cultures on electrode arrays, using a cholinergic agonist, Carbachol (CCh). Application of CCh resulted in a loss of regularity, a less precise synchronization, and a fragmentation of the burst structure. We found that temporal properties of spike trains were well-characterized by a simple Poisson cluster-process model, which provided a precise insight into the temporal structure of spike trains and allowed quantitative fitting of the spectral changes induced by CCh. These results should help to elucidate the complex actions of cholinergic modulation on cortical cells in intact neural networks.
  • Y Jimbo, N Kasai, K Torimitsu, T Tateno, HPC Robinson
    IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 50 2 241 - 248 2003年02月 [査読有り][通常論文]
     
    The capability for multisite stimulation is one of the biggest potential advantages of microelectrode arrays (MEAs). There remain, however, several technical problems which have hindered the development of a practical stimulation system. An important design goal is to allow programmable multisite stimulation, which produces minimal interference with simultaneous extracellular and patch or whole cell clamp recording. Here, we describe a multisite stimulation and recording system with novel interface circuit modules, in which preamplifiers; and transistor transistor logic-driven solid-state switching devices are integrated. This integration permits PC-controlled remote switching of each substrate electrode. This allows not only flexible selection of stimulation sites, but also rapid switching. of the selected sites between stimulation and recording, within 1.2 ms. This allowed almost continuous monitoring of extracellular signals at all the substrate-embedded electrodes, including those used for. stimulation. In addition, the vibration-free solid-state switching made it possible to record whole-cell synaptic currents in one neuron, evoked from multiple sites in the network. We have used this system to visualize spatial propagation patterns. of evoked responses in cultured networks of cortical neurons. This MEA-based stimulation system is a useful tool for studying neuronal signal processing in biological neuronal networks, as well as the process of synaptic integration within single neurons.
  • Takashi Tateno, Akio Kawana, Yasuhiko Jimbo
    Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 65 5 051924/16  2002年05月 [査読有り][通常論文]
     
    We have used a multiunit electrode array in extracellular recording to investigate changes in the firing patterns in networks of developing rat cortical neurons. The spontaneous activity of continual asynchronous firing or the alternation of asynchronous spikes and synchronous bursts changed over time so that activity in the later stages consisted exclusively of synchronized bursts. The spontaneous coordinated activity in bursts produced a variability in interburst interval (IBI) sequences that is referred to as "form." The stochastic and nonlinear dynamical analysis of IBI sequences revealed that these sequences reflected a largely random process and that the form for relatively immature neurons was largely oscillatory while the form for the more mature neurons was Poisson-like. The observed IBI sequences thus showed changes in form associated with both the intrinsic properties of the developing cells and the neural response to correlated synaptic inputs due to interaction between the developing neural circuits. © 2002 The American Physical Society.
  • T Tateno
    PHYSICAL REVIEW E 65 2 021901  2002年02月 [査読有り][通常論文]
     
    This study provides a method for calculating first-order approximations of the Lyapunov exponents of systems with discontinuity in the presence of noise in order to characterize the stability of motions in those systems. This paper in particular illustrates the results of the ways in which noise influences period-doubling bifurcation in the parameter space of an integrate-and-fire model with a periodically modulated reset level. For evaluating a stochastic version of period-doubling bifurcation, the first-passage-time problem of the Ornstein-Uhlenbeck process is used to define a Markov operator governing the transition of a reset-level phase density. The results on the stochastic bifurcation are thus compared with numerical computations of angles and moduli of eigenvalues of the Markov operator that describes the firing properties of the model.
  • T Tateno, Y Jimbo
    PHYSICS LETTERS A 271 4 227 - 236 2000年07月 [査読有り][通常論文]
     
    We investigated the ways in which noise influences lower-order mode-locked regions (Arnold tongues) in the parameter space of an integrate-and-fire model with a periodically modulated threshold. To study the stochastic mode-locking in the model, we use the first-passage-time problem of the Ornstein-Uhlenbeck process with a periodic boundary to define the Markov operator governing the transition of a threshold phase density. We present a numerical method for evaluating stochastic bifurcation by spectral analysis of the operator and briefly discuss the implications for biological systems. (C) 2000 Elsevier Science B.V. All rights reserved.
  • T Tateno, Y Jimbo
    IEEE-EMBS ASIA PACIFIC CONFERENCE ON BIOMEDICAL ENGINEERING - PROCEEDINGS, PTS 1 & 2 139 - 140 2000年 [査読有り][通常論文]
     
    Several linear signal methods for estimation of the propagating time between two extracellular recording sites were compared using compartmental and cell-electrode junction models. The simulation results show that the maximum likelihood estimation gives reliable values and that the signal-to-noise ratio of extracellularly recorded signals increases monotonically as the sealing resistance of electrodes increases over 10 k Omega.
  • Y Jimbo, T Tateno, HPC Robinson
    BIOPHYSICAL JOURNAL 76 2 670 - 678 1999年02月 [査読有り][通常論文]
     
    Activity-dependent modification of synaptic efficacy is widely recognized as a cellular basis of learning, memory, and developmental plasticity. Little is known, however, of the consequences of such modification on network activity. Using electrode arrays, we examined how a single, localized tetanic stimulus affects the firing of up to 72 neurons recorded simultaneously in cultured networks of cortical neurons, in response to activation through 64 different test stimulus pathways. The same tetanus produced potentiated transmission in some stimulus pathways and depressed transmission in others. Unexpectedly, responses were homogeneous: for any one stimulus pathway, neuronal responses were either all enhanced or all depressed. Cross-correlation of responses with the responses elicited through the tetanized site revealed that both enhanced and depressed responses followed a common principle: activity that was closely correlated before tetanus with spikes elicited through the tetanized pathway was enhanced, whereas activity outside a 40-ms time window of correlation to tetanic pathway spikes was depressed. Response homogeneity could result from pathway-specific recurrently excitatory circuits, whose gain is increased or decreased by the tetanus, according to its cross-correlation with the tetanized pathway response. The results show how spatial responses following localized tetanic stimuli, although complex, can be accounted for by a simple rule for activity-dependent modification.
  • T Tateno, Y Jimbo
    BIOLOGICAL CYBERNETICS 80 1 45 - 55 1999年01月 [査読有り][通常論文]
     
    To study the use-dependent modification of activity in neural networks, we investigated the spike timing by simultaneously recording activity at multiple sites in a network of cultured cortical neurons. We used dynamical analysis to study the temporal structure of spike trains and the activity-dependent changes in the reliability and reproducibility of spike patterns evoked by a stimulus. We also used cross-correlation analysis to evaluate the interactions of neuron pairs. Our main conclusions are that even when no obvious change in spike numbers can be seen, use-dependent modification occurs, either enhancing or reducing in the reliability and reproducibility of spike trains evoked by a stimulus, and the fine temporal structure of stimulus-evoked spike trains and interactions between neurons are also modified by tetanic stimulation.
  • T Tateno
    JOURNAL OF STATISTICAL PHYSICS 92 3-4 675 - 705 1998年08月 [査読有り][通常論文]
     
    This study of the effect of noise on bifurcations in a simple biological oscillator with a periodically modulated threshold uses the first-passage-time problem of the Ornstein-Uhlenbeck process with a periodic boundary to define the operator governing the transition of a threshold phase: density. Stochastic phase locking is analyzed numerically by evaluating the evolution of the probability density function of the threshold phase. A firing phase map in a noisy environment is extended to a stochastic kernel ss that stochastic bifurcations can be investigated by spectral analysis of the kernel.
  • T Tateno, Y Jimbo, A Kawana
    ICONIP'98: THE FIFTH INTERNATIONAL CONFERENCE ON NEURAL INFORMATION PROCESSING JOINTLY WITH JNNS'98: THE 1998 ANNUAL CONFERENCE OF THE JAPANESE NEURAL NETWORK SOCIETY - PROCEEDINGS, VOLS 1-3 1563 - 1566 1998年 [査読有り][通常論文]
     
    The self-organization in immature neuronal networks and the characteristics of spike trains during the early period of spontaneous activity are studied by culturing rat dissociated cortical neurons on substrates containing multi-electrode arrays. We use nonlinear forecasting to search series of interspike or interburst interval times for evidence of determinism. This analysis yields evidence of weak determinism in two of seven early stage cultures. Neuron activity is also analyzed by hidden Markov models to estimate the number of neuronal groups forming local assemblies via synchronization during network development.
  • T TATENO, S DOI, S SATO, LM RICCIARDI
    NUOVO CIMENTO DELLA SOCIETA ITALIANA DI FISICA D-CONDENSED MATTER ATOMIC MOLECULAR AND CHEMICAL PHYSICS FLUIDS PLASMAS BIOPHYSICS 17 7-8 949 - 958 1995年07月 [査読有り][通常論文]
     
    Noise effects on phase lockings in a system consisting of a piecewise-linear van der Pol relaxation oscillator driven by a periodic input are studied. The problem of finding the period of the oscillator is reduced to the first-passage-time problem of the Ornstein-Uhlenbeck process with time-varying boundary. Using the probability density functions of the first-passage time, the operator which governs a transition of an input phase density after one cycle of the oscillator is defined. Phase lockings in a stochastic sense are investigated on the basis of the density evolution by the operator.
  • T TATENO, SJ DOI, S SATO, LM RICCIARDI
    JOURNAL OF STATISTICAL PHYSICS 78 3-4 917 - 935 1995年02月 [査読有り][通常論文]
     
    Noise effects on phase lockings in a system consisting of a piecewise-linear van der Pol relaxation oscillator driven by a periodic input are studied. The problem of finding the period of the oscillator is reduced to the first-passage-time problem of the Ornstein-Uhlenbeck process with time-varying boundary. The probability density functions of the first-passage time are used to define the operator which governs a transition of an input phase density after one cycle of the oscillator. Phase lockings in a stochastic sense are investigated on the basis of the density evolution by the operator.
  • Hybrid-type modeling of the peripheral auditory system using a piezoelectric acoustic sensor as a front-end transducer for sound processing
    T. Tateno
    [査読有り][通常論文]
  • Developing technology that integrates microdevices and the auditory central nervous system ― Microstructure devices and functional artificial auditory organs
    舘野高
    [査読有り][通常論文]

MISC

  • 長内尚之, 三幣俊輔, 舘野高 電子情報通信学会技術研究報告 117 (508(NC2017 67-98)) 2018年
  • 村上 修一, 佐藤 和郎, 高橋 壮太, 舘野 高 「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編] 34 1 -4 2017年10月31日
  • 三幣 俊輔, 舘野 高 電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 116 (521) 143 -148 2017年03月13日
  • 三幣俊輔, 長内尚之, 舘野高 電気学会電子・情報・システム部門大会講演論文集(CD-ROM) 2017 2017年
  • 橘 唯至, 舘野 高, 西川 淳 電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 115 (514) 173 -178 2016年03月22日
  • 岩城 遼, 村上 修一, 佐藤 和郎, 舘野 高 電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 115 (514) 179 -184 2016年03月22日
  • 羽賀 健亮, 舘野 高, 西川 淳 電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 115 (384) 19 -24 2015年12月19日
  • 能登 雅成, 西川 淳, 舘野 高 聴覚研究会資料 = Proceedings of the auditory research meeting 43 (8) 651 -656 2013年11月28日
  • Takashi Tateno, Robinson Hugh NEUROSCIENCE RESEARCH 71 E314 -E314 2011年 [査読無し][通常論文]
  • 岩橋 亮平, 舘野 高 電子情報通信学会技術研究報告. NC, ニューロコンピューティング 109 (461) 39 -44 2010年03月02日 
    Caイメージングに用いられるCaプローブは,それ自体がキレータとして働くため,高濃度のCaプローブを用いると,本来の細胞内Ca^<2+>動態を乱す.そのため,Caプローブが細胞内Ca^<2+>動態に与える影響を定量的に測り,Caプローブの影響を考慮してCa^<2+>動態を推定する必要がある.本研究は,その第一段階として,Ca^<2+>電流と蛍光信号強度の同時計測結果から,細胞内Caプローブ濃度を推定する手法を提案する.本手法では,細胞内Ca^<2+>動態と膜電流計測過程,および,蛍光信号強度の計測過程を状態空間モデルとして記述する.次に,状態変数と未知パラメータを同時に推定するために,状態空間モデルを自己組織型状態空間モデルに拡張する.このモデルは非線形・非ガウス型となるため,状態推定には粒子フィルタ法を用いる.さらに,数値実験により,提案手法の有効性を検証する.最後に,本手法の具体的な応用例と今後の拡張法について述ペる.
  • 河野通太, 舘野高 電子情報通信学会技術研究報告. NC, ニューロコンピューティング 108 (480) 87 -92 2009年03月04日 [査読無し][通常論文]
     
    本研究では,大脳基底核黒質緻密部におけるドーパミン作動性(DA)細胞の時空間的シナプス入力の統合とその符号化様式を理解するために,まず,二重免疫染色法を用いて,ラット黒質部のDA細胞形態を詳細に計測した.次に,Rallの等価シリンダモデルの観点から,実際に計測した細胞形態データが,そのモデル化の条件を満たすか否かを検討した.さらに,DA細胞を受動的膜と見なした場合に,樹状突起の分岐点で膜電位伝達の効率性を理解することを試みた.特に,細胞間,あるいは,細胞内で膜電位を効率的に伝播する特異的樹状突起を有しているかについて実験データを基に検証した.また,有限要素法を応用した樹状突起モデルの一構成法の計算機による実装方法とその具体的な応用例を述べる.
  • 岩橋亮平, 舘野高 電子情報通信学会技術研究報告. NC, ニューロコンピューティング 107 (542) 255 -260 2008年03月05日 [査読無し][通常論文]
     
    本研究では,大脳基底核黒質緻密部の局所回路特性の理解を目指して,ラット脳切片を用いて神経細胞の電気的特性を実験的に調べた.特に,黒質の神経細胞の電気生理学特性に基づく細胞分類の可能性を検討する為に,ホールセルパッチクランプ法を用いて細胞の膜電位と電流を計測した.その結果,まず,先行研究が示すように,活動電位の幅が広く低周波数で発火する神経細胞(第一細胞)と活動電位の幅が狭く高周波数で発火する神経細胞(第二細胞)の二種類に分類できた.次に,免疫組織化学法を用いて,電気活動を計測した第一細胞がドーパミン作動性(DA)であるかを調べた.その結果,第一細胞には,DAと非DAが混在していることが判った.さらに,第二細胞群をいくつかの電気的特徴からサブタイプに分類できるかを検討した.細胞間には,その特徴が大きく異なっているものが存在するが,細胞群全体の特徴パラメータはその空間上に連続的に分布しており,単純な基準ではサブタイプに分類することが困難であることが判明した.
  • Ryohei Iwahashi, Takashi Tateno NEUROSCIENCE RESEARCH 61 S214 -S214 2008年 [査読無し][通常論文]
  • 阿登正憲, 舘野高 電子情報通信学会技術研究報告. NC, ニューロコンピューティング 106 (588) 43 -48 2007年03月07日 [査読無し][通常論文]
     
    近年,大脳皮質体性感覚野において,抑制性介在細胞が細胞種毎に特異的な細胞間結合を形成することが明らかになってきた.しかし,現在,各細胞種が神経回路網の中でどのような役割を果たしているかは明確ではない.本研究では,抑制性介在細胞の中でfast spiking細胞とよばれる神経細胞とそのK^+チャネルに着目した.まず,生理実験と計算機シミュレーションによって,周期的な発火活動中に摂動電流を印加し,動的特性を知る為に位相反応曲線を計測,および,推定した.得られた位相反応曲線を基に,周期振動における一次元位相方程式モデルを作成した.そして,確率的力学系理論に基づき,白色雑音下の位相方程式の振動安定性の指数を計算した.その結果,イオンチャネル種の相対的な寄与の大きさによって,振動安定性に違いがあることが判明した.本稿では,こうした結果を基に,神経回路網におけるfast spiking細胞とそのK^+チャネル電流の役割を議論する.
  • 舘野高 電子情報通信学会技術研究報告. NC, ニューロコンピューティング 105 (658) 13 -18 2006年03月09日 [査読無し][通常論文]
     
    近年,大脳皮質体性感覚野において,抑制性介在細胞が細胞種毎に特異的な細胞間結合を形成することが明らかになってきた.しかし,それらの細胞種に関して,神経振動における安定性が定量的にどの程度かは知られていない.本研究では,まず,非線形力学系の観点から,細胞種分類が可能か否かを検討した.そして,周期的な発火活動中に微小な電流外乱を印加し,実験的に位相反応曲線を計測した.得られた位相反応曲線を下に,周期振動における一次元位相方程式モデルを作成した.そして,確率的力学系理論に基づき,白色雑音下の位相方程式の振動安定性指数を計算した.その結果,細胞種間に振動安定性の違いがあることが判明した.本稿では,こうした結果を基に,神経回路網における細胞種の役割を議論する.
  • Takashi Tateno, Hugh P. C. Robinson NEUROSCIENCE RESEARCH 55 S137 -S137 2006年 [査読無し][通常論文]
  • 舘野高 電子情報通信学会技術研究報告. NLP, 非線形問題 100 (608) 71 -78 2001年01月25日 [査読無し][通常論文]
     
    本研究では, 単位円上の単純な一次元2状態系を扱う。この系は振動, 興奮, 双(多)安定な振舞いを示す。システムの確率的現象の性質を知るために, 信号対雑音比, パワー・スペクトル, Lyapunov指数などの道具を準備する。システムの分岐点近傍での確率的現象と出力コヒーレンスとの関係を理解することを目的とし, その第一歩として, これらの道具を用いて数値解析を行った結果を本稿では述べる。
  • 鶴賀英高, 舘野高, 佐藤俊輔 電子情報通信学会技術研究報告. MBE, MEとバイオサイバネティックス 100 (98) 133 -140 2000年05月19日 [査読無し][通常論文]
     
    本研究では, 神経束の情報伝達を調べるために, 並列構造をもつ多数の神経モデルの応答の全体効果を評価する.我々は, ノイズ存在下での周期的シナプス入力を受けるleaky integrate-and-fire神経モデル(LIFM)集合の応答特性を調べる.LIFM集合の応答は各ユニットの出力スパイク列の総和からなる点過程であり, その発火分布を数値計算し, 入力とノイズのパラメータによる発火特性を調べる.さらに, ポアソン過程に基づく発火間隔分布とLIFMの微分方程式から得たスパイク列の分布を, Kullback-Leibler情報量を用いて比較する.我々の結果は, 神経束による情報伝達と符号化を評価するために, 感覚末梢系のモデルとして応用することができる.
  • Y Jimbo, T Tateno, HPC Robinson EUROPEAN JOURNAL OF NEUROSCIENCE 10 222 -222 1998年 [査読無し][通常論文]
  • 舘野 高, 神保 泰彦, 川名 明夫 生体・生理工学シンポジウム論文集 12 65 -68 1997年09月04日
  • 舘野 高, 平原 達也 日本音響学会研究発表会講演論文集 1996 (1) 447 -448 1996年03月01日
  • 舘野 高, 平原 達也 日本音響学会研究発表会講演論文集 1995 (2) 423 -424 1995年09月01日
  • 舘野 高, 平原 達也 電子情報通信学会技術研究報告. EA, 応用音響 95 (207) 9 -16 1995年08月21日 
    聴覚系の音響情報処理機構を理解することを目的として、聴覚末梢系の中の外耳,中耳,基底膜振動系モデルを計算機上に実現する。既存の実体モデルの中から聴覚末梢系の伝達特性や物理的な運動をある程度忠実に再現すると考えられるものをとりあげ,それらを計算機上で模擬するための計算方法やそのモデルのパラメータ決定法について検討した結果を述べる。

書籍等出版物

  • 生物音響学会 (担当:分担執筆)
    朝倉書店 2019年11月 (ISBN: 9784254171679) xii, 441, 4p, 図版 [4] p
  • Phase-resetting analysis of gamma-frequency synchronization of cortical fast-spiking interneurons using synaptic-like conductance injection”, in Phase response curves in neuroscience: theory, experiment and analysis
    P. Zeberg, N. W. Gouwens, K. Tsumoto, T. Tateno, K. Aihara, H. P. C. Robinson (担当:共著)
    2012年
  • Dynamics of Cortical Neurons and Spike Timing Variability”, in Complex Medical Engineering
    舘野高 (担当:単著範囲:565-572)
    2007年
  • Simple dynamical models to understand the mechanisms of drug addiction
    舘野高 (担当:単著範囲:Chap. 93, Advances in Cognitive Neurodynamics (III))
    Springer

講演・口頭発表等

  • 簡易シナプスモデルの効率的なパラメータ推定によるマウス聴覚皮質内の長期可塑性における主要なシナプス受容体の探索  [通常講演]
    古川凌, 舘野高
    第46回情報理論とその応用シンポジウム 2023年12月 口頭発表（一般）
  • Bidirectional modulation effects on neural activity induced by near-infrared light stimulation to the mouse inferior colliculus in vivo  [通常講演]
    T. TATENO, F. SUGIMOTO, H. SATO
    Neuroscience 2023 (Society for Neuroscience) 2023年11月 ポスター発表
  • 小動物の機能的神経結合の推定を目指した in vivo 局所電磁気刺激と脳波多点計測  [通常講演]
    川勝 孝基, 舘野 高
    2023年電気学会 電子・情報・システム部門大会 2023年08月 ポスター発表
  • 近赤外光温熱刺激が in vivoマウス下丘の音誘発と自発の神経活動に及ぼす変調効果  [通常講演]
    佐藤 広務, 杉本 太, 舘野 高
    第46回日本神経科学大会 2023年08月
  • 数値解析および動物実験に基づく電気刺激極性が特徴づけるマウス脳波誘発応答の解析  [通常講演]
    川勝 孝基, 舘野 高
    第46回日本神経科学学会 2023年08月 ポスター発表
  • 耳毒性難聴マウスを用いた超音波脳刺激における聴覚の末梢系と中枢系の神経応答解析  [通常講演]
    舘野 高, 石川 瑛大, 坂上 雅明
    第46回日本神経科学学会 2023年08月
  • 簡易的可塑性モデルがin vitroマウス聴覚皮質の受容体拮抗薬下の長期抑圧の時間的動態を明らかにする  [通常講演]
    古川凌, 舘野高
    第46回日本神経科学大会 2023年08月
  • 局所的な電気刺激が誘発する小動物脳波応答の時空間的解析 -脳内電場分布推定とフレキシブル基板多点計測との比較-  [通常講演]
    川勝 孝基, 舘野 高
    令和4年度電子情報通信学会北海道支部学生会インターネットシンポジウム 2023年02月
  • 経頭蓋超音波刺激における齧歯類の頭蓋振動と聴性脳幹誘発応答の相関解析  [通常講演]
    坂上雅明, 舘野 高
    2022年 電気学会 電子・情報・システム部門大会 2022年08月 広島大学東広島キャンパス
  • A piezoelectric micromachined ultrasound transducer with the interface of simultaneous measurement of neural activity in vitro  [通常講演]
    Ryo Furukawa, Takashi Tateno
    2022 Annual Conference on Electronics,Information and Systems Institute of Electrical Engineers of Japan(IEEJ) 2022年08月
  • Magnetic Stimulation Conditions Needed for Localized Electrophysiological Responses in Mouse Auditory Cortex in vivo  [通常講演]
    Takahiro Yoshikawa, Takashi Tateno
    2022 Annual Conference on Electronics,Information and Systems Institute of Electrical Engineers of Japan(IEEJ) 2022年08月
  • In vivo近赤外光神経刺激によって誘発されるマウス下丘での双方向性の神経活動変調効果  [通常講演]
    佐藤 広務, 舘野高
    第45回日本神経科学大会 2022年07月 沖縄県 宜野湾市
  • 音響圧分布と in vitroマウス脳スライスの皮質回路網を反映した超音波誘発応答の時空間的解析  [通常講演]
    古川凌, 金田弘貴, 舘野高
    第45回日本神経科学大会 2022年07月 沖縄県 宜野湾市
  • 脳内電場分布計算に基づく局所パルス磁気刺激のマウス大脳皮質誘発応答特性 －効果的な経頭蓋可塑性誘導法の開発に向けて－  [通常講演]
    吉川隆洋, 舘野高
    令和3年度電子情報通信学会北海道支部学生会インターネットシンポジウム
  • Development of a Piezoelectric Micromachined Ultrasound Transducer using Microfabrication Technology for in Vitro Neuromodulation  [通常講演]
    Ryo Furukawa, Takashi Tateno
    BIODEVICES 2022 2022年02月
  • 微細加工技術による圧電型マイクロ超音波トランスデューサの開発－In vitro超音波神経刺激実験への応用－  [通常講演]
    古川凌, 舘野高
    令和３年度電気・情報関係学会北海道支部連合大会 2021年11月 その他
  • MEMS圧電性トランスデューサの開発：超音波ニューロモジュレーションへの応用  [通常講演]
    古川凌, 舘野高
    北海道大学部局横断シンポジウム 2021年10月
  • 老化促進モデルマウスにおける難聴および時間処理障害の評価：聴性脳幹反応および音響驚愕反射ギャッププレパルス抑制を用いた研究  [通常講演]
    石坂 駿人, 舘野 高, 西川 淳
    第36回老化促進モデルマウス(SAM)学会学術大会 2021年09月
  • Development of a piezoelectric micromachined ultrasound transducer using microfabrication technology -Aiming to realize the efficient induction of responses in local neural networks  [通常講演]
    Ryo Furukawa, Takashi Tateno
    電気学会 電子・情報・システム部門大会 2021年09月
  • Spatio-temporal analysis of cortical response properties induced by the magnetic stimulation of millimeter-sized coils to mouse brain in vivo  [通常講演]
    Takashi Tateno
    Neuroscience 2021,the 44th Annual Meeting of the Japan Neuroscience Society 2021年07月
  • Evaluation of hearing loss and temporal processing deficits in senescence-accelerated mice: a study using auditory brainstem response and gap pre-pulse inhibition of acoustic startle reflex  [通常講演]
    Hayato Ishizaka, Takashi Tateno, Jun Nishikawa
    Neuroscience 2021,the 44th Annual Meeting of the Japan Neuroscience Society 2021年07月
  • 超音波脳刺激に適した圧電性マイクロトランスデューサの一構成法ー物理モデルの数値計算と構造サイズ間の近似式の提案ー  [通常講演]
    古川凌, 舘野高
    電子情報通信学会 北海道支部 学生会 インターネットシンポジウム 2021年02月
  • 騒音誘発性耳鳴りはマウス聴覚皮質においてgap-in-noise音に対する神経応答を変化させる  [通常講演]
    中島 優花, 舘野 高, 西川 淳
    第30回 日本神経回路学会 全国大会 (JNNS2020) 2020年12月
  • マウス脳に応用するミリサイズコイルの経頭蓋磁気刺激法の開発とその評価  [通常講演]
    樋口 久也, 舘野 高
    令和2年度電気・情報関係学会北海道支部連合大会 2020年11月
  • Noise-induced tinnitus causes changes of neural responses to gap-in-noise sound in the mouse auditory cortex  [通常講演]
    Yuka Nakajima, Takashi Tateno, Jun Nishikawa
    The 43rd Annual Meeting of the Japan Neuroscience Society 2020年07月
  • Developing a transcranial ultrasound brain stimulation method to highly localized evoked response area in the mouse auditory cortex: numerical simulation and experimental evaluation  [通常講演]
    Takashi Tateno, Masato Toda, Hiroki, Kaneta, Jun Nishikawa
    The 43rd Annual Meeting of the Japan Neuroscience Society 2020年07月
  • Neural correlates of gap detection deficits related to tinnitus in the mouse auditory corte  [通常講演]
    Jun Nishikawa, Motoki Yanada, Takashi Tateno
    The 43rd Annual Meeting of the Japan Neuroscience Society 2020年07月
  • Development and evaluation of a transcranial magnetic stimulation method with millimeter-size coils applied to the mouse brain  [通常講演]
    Hisaya Higuchi, Takashi Tateno
    The 43rd Annual Meeting of the Japan Neuroscience Society 2020年07月
  • Construction of a multielectrode-array-based measuring system to elucidate the mechanism of ultrasound-driven neural activity in mouse cortical slice  [通常講演]
    Hiraki Kaneta, Takashi Tateno
    The 43rd Annual Meeting of the Japan Neuroscience Society 2020年07月
  • 老化促進モデルマウス2系統(SAMP1とSAMR1) における難聴および時間処理障害の評価  [通常講演]
    石坂駿人, 舘野高, 西川淳
    第35回 老化促進モデルマウス（SAM）学会学術大会 2020年06月
  • In vivo神経活動を誘発するマイクロ磁気刺激法の基礎的検討  [通常講演]
    須貝 俊介, 西川 淳, 佐藤 和郎, 村上 修一, 舘野 高
    令和２年電気学会全国大会 2020年03月
  • 齧歯類可聴域に周波数選択性を有する圧電性音響センサの開発  [通常講演]
    桑野 拓巳, 西川 淳, 佐藤 和郎, 村上 修一, 舘野 高
    令和２年電気学会全国大会 2020年03月 その他
  • マイクロ磁気刺激におけるコイル誘導電場の数値解析と神経誘発応答に基づく評価  [通常講演]
    須貝俊介, 西川淳, 舘野高
    電子情報通信学会，ニューロコンピューティング研究会 2019年12月
  • 齧歯類動物可聴域に周波数選択的を有する圧電性音響センサの開発とその特性評価  [通常講演]
    桑野拓巳, 西川淳, 舘野高
    電子情報通信学会，ニューロコンピューティング研究 2019年12月
  • 聴覚系における集団符号化の簡易計算モデル ―2つの目的関数における最適受容野の比較―  [通常講演]
    舘野高
    電気学会 電子・情報・システム部門大会 2019年09月
  • In vivo ラット聴覚皮質の時間周波数受容野における多点電極刺激に誘発され可塑的変化  [通常講演]
    菊池大夢, 舘野高, 西川淳
    令和元年電気学会電子・情報・システム部門大会 2019年09月
  • マウス聴覚皮質におけるgap誘発神経応答の耳鳴り状態依存的な変化  [通常講演]
    簗田元揮, 中島優花, 舘野高, 西川淳
    令和元年電気学会電子・情報・システム部門大会 2019年09月
  • In vitro神経回路を局所的に活動誘発させる超音波刺激条件のFDTD法を用いた探索  [通常講演]
    金田弘貴, 舘野高
    電気学会 電子・情報・システム部門大会 2019年09月
  • In vivoマウス聴覚皮質における音誘発応答を模擬した電気的刺激法の開発  [通常講演]
    Takashi Tateno, Shuto Muramatsu, Masato Toda, Jun Nishikawa
    日本神経科学会大会 2019年07月
  • Salicylate-induced tinnitus suppresses neural responses evoked by gap onset in the mouse auditory cortex  [通常講演]
    Motoki Yanada, Takashi Tateno, Jun Nishikawa
    Neuroscience2019 (The 42th Annual Meeting of the Japan Neuroscience Society 2019年07月
  • 耳鳴り状態のマウスでは聴覚皮質におけるgap誘発応答が変化する  [通常講演]
    簗田元揮, 舘野高, 西川淳
    第4回 北海道大学 部局横断シンポジウム 2019年01月
  • 聴覚損傷モデルマウスにおける経頭蓋フラビンタンパク質自家蛍光イメージングを用いた聴覚皮質音誘発応答の経時的計測  [通常講演]
    鷹巣健吾, 舘野高
    電気学会 電子・情報・システム部門大会 2018年09月
  • 音響驚愕反射を用いた耳鳴り評価法における音刺激パラメータ依存性 –背景雑音に埋め込まれるギャップのfade-inとfade-outの効果-  [通常講演]
    簗田元揮, 舘野高, 西川淳
    電気学会 電子・情報・システム部門大会 2018年09月
  • 超音波脳刺激システムにおけるFDTD法を用いたwaveguide形状の最適化  [通常講演]
    戸田聖人, 舘野高
    電気学会 電子・情報・システム部門大会 2018年09月
  • In vivoマウス聴覚皮質の層選択的微小電気刺激に誘発される皮質神経活動の層依存的特徴  [通常講演]
    村松修斗, 舘野高
    電気学会 電子・情報・システム部門大会 2018年09月
  • マウス聴覚皮質第 4 層における活動依存的な長期抑圧の時空間的な特徴解析： NMDA and GABAA受容体の依存性  [通常講演]
    久米航太, 舘野高
    平成30年 電気学会 電子・情報・システム部門大会 2018年09月
  • Layer-dependent changes of the responses induced by electric microstimulation in the mouse auditory cortex in vivo  [通常講演]
    Shuto Muramatsu, Takashi Tateno
    The 41st Annual Meeting of the Japan Neuroscience Society 2018年07月
  • Repetitive recordings of sound-driven responses in individual mice for a hearing-impaired model using transcranial flavoprotein autofluorescence imaging in vivo  [通常講演]
    Takasu, K, Tateno, T
    The 41st Annual Meeting of the Japan Neuroscience Society 2018年07月
  • 微小コイル磁気刺激法における大脳皮質誘発応答の空間局所性 ～ 電気生理学的評価 ～  [通常講演]
    長内尚之, 三幣俊輔, 舘野 高
    2018年03月
  • Microcoil-driven responses induced by magnetic stimulation spatially restricted to the local surface of the mouse auditory cortex in vivo  [通常講演]
    H. OSANAI, S. MINUSA, T. TATENO
    Annual meeting of Society for Neuroscience 2017 2017年11月
  • MEMS中枢神経刺激用多電極インターフェースの 作製とその評価  [通常講演]
    村上修一, 佐藤和郎, 高橋壮太, 舘野高
    第34回「センサ・マクロマシンと応用システム」シンポジウム 2017年10月
  • 耳鳴の周波数地図再組織化 －効率的符号化原理と聴覚系秩序の崩壊－  [通常講演]
    舘野高, 西川淳
    第27回 日本数理生物学会年会 2017年10月
  • 耳鳴り誘導剤投与下のラット聴覚皮質における音刺激誘発電位応答のスペクトル解析  [通常講演]
    戸田聖人, 長内尚之, 舘野高
    平成29年 電気学会 電子・情報・システム部門大会 2017年09月
  • 聴覚皮質における時間周波数受容野の実時間推定法とそのFPGAへの実装  [通常講演]
    小杉倭弘, 西川淳, 浅井哲也, 舘野高
    平成29年 電気学会 電子・情報・システム部門大会 2017年09月
  • 神経刺激のための埋込型微小磁気刺激システムの開発とその評価  [通常講演]
    三幣俊輔, 長内尚之, 舘野高
    平成29年 電気学会 電子・情報・システム部門大会 2017年09月
  • 齧歯類動物向け聴覚中枢系補綴器の開発  [通常講演]
    村上修一, 高橋壮太, 岩城 遼, 佐藤和郎, 田中恒久, 宇野真由美, 舘野 高
    第8回集積化MEMS技術研究ワークショップ 2017年07月
  • In vitroマウス聴覚皮質第4/5層の錐体細胞における磁気刺激誘発応答  [通常講演]
    並川 稔, 舘野高
    第40回日本神経科学大会 2017年07月
  • 埋込型微小磁気刺激装置における神経活動誘発可能性の理論計算と実験による検討  [通常講演]
    三幣 俊輔, 舘野高
    第40回日本神経科学大会 2017年07月
  • マウス聴覚野の領域と層構造に特化したインターフェスにおける多点刺激デバイスの開発  [通常講演]
    高橋 壮太, 村上修一, 佐藤和郎, 舘野高
    第40回日本神経科学大会 2017年07月
  • 聴覚皮質内因性信号の光計測法を用いた埋込型微小磁気刺激法による誘発神経応答評価  [通常講演]
    三幣俊輔, 舘野 高
    2017年03月
  • Combining multi-unit recording and flavoprotein fluorescence imaging reveals field- and layer-specific sound-evoked neural responses in the rodent auditory cortex  [通常講演]
    Jun Nishikawa, Takeaki Haga, Yuishi Tachibana, Yuto Ohtaka, Yasutaka Yanagawa, Hisayuki Osanai, Takashi Tateno
    The 46th Annual meeting of Society for Neuroscience (Neuroscience 2016) 2016年11月
  • Neural response differences in the rat primary auditory cortex under anesthesia with ketamine versus the mixture of medetomidine, midazolam and butorphanol  [通常講演]
    H. Osanai, T. Tateno
    The 46th Annual meeting of Society for Neuroscience (Neuroscience 2016) 2016年11月 口頭発表（一般）
  • 聴覚皮質局所回路における誘発応答の計測とその制御  [通常講演]
    西川淳, 舘野高
    計測自動制御学会 ライフエンジニアリング部門シンポジウム2016 2016年11月
  • Developing an Implantable Micro Magnetic Stimulation System to Induce Neural Activity in Vivo  [通常講演]
    S. Minusa, T. Tateno
    The 23rd International Conference on Neural Information Processing (ICONIP 2016 2016年10月
  • Differential Effect of Two Types of Anesthesia on Sound-Driven Oscillations in the Rat Primary Auditory Cortex  [通常講演]
    H. Osanai, T. Tateno
    The 23rd International Conference on Neural Information Processing (ICONIP 2016) 2016年10月
  • An Analysis of Current Source Density Profiles Activated by Local Stimulation in the Mouse Auditory Cortex in Vitro  [通常講演]
    D. Yamamura, S. Ayaka, T. Tateno
    The 23rd International Conference on Neural Information Processing (ICONIP 2016) 2016年10月
  • 齧歯類実験動物における特定音波検知MEMSセンサの作製  [通常講演]
    村上 修一, 岩城 遼, 佐藤 和郎, 田中 恒久, 宇野真由美, 舘野 高
    77回 応用物理学会秋季学術講演会 2016年09月
  • 3種の麻酔薬における経頭蓋フラビンタンパク質自家蛍光イメージングを用いたマウス聴覚皮質の音刺激誘発応答計測  [通常講演]
    柳川 康貴, 舘野 高
    第39回日本神経科学大会 2016年07月
  • 多点電極計測とフラビンタンパク質蛍光イメージングにより明らかにされる齧歯類聴覚皮質における脳領域および層依存的な音誘発応答  [通常講演]
    西川 淳, 羽賀 健亮, 橘 唯至, 大高 友斗, 柳川 康貴, 長内尚之, 舘野 高
    第39回日本神経科学大会 2016年07月
  • ラット聴覚野における聴覚誘導に関連した神経活動：膜電位感受性色素を用いた光計測による検討  [通常講演]
    能登将成, 西川淳, 舘野高
    社団法人 日本音響学会 聴覚研究会 2013年11月 ポスター発表
  • Multielectrode array recording of propagation of activity evoked by electrical micro-stimulation in horizontal and coronal slices of the mouse auditory cortex  [通常講演]
    H. Kitamura, J. Nishikawa, T. Tateno
    The 43rd Annual Meeting of the Society for Neuroscience (Neuroscience 2013) 2013年11月
  • Unidirectional dual-component propagation of neural activity evoked by sound and electrical stimulation in rat multiple auditory cortical fields revealed by optical imaging with voltage-sensitive dye  [通常講演]
    J. Nishikawa, M. Noto, H. Kitamura, T. Tateno
    The 43rd Annual Meeting of the Society for Neuroscience (Neuroscience 2013) 2013年11月
  • Voltage-sensitive dye imaging of unidirectional dual-component propagation of activity evoked by sound and electrical stimulation in rat multiple auditory cortical fields  [通常講演]
    Jun Nnishikawa, Masanari Noto, Hiroyuki Kitamura, Takashi Tateno
    The 43rd Annual Meeting of the Society for Neuroscience (Neuroscience 2013) 2013年11月 ポスター発表
  • Multielectrode array recording of propagation of activity evoked by electrical micro-stimulation in horizontaland coronal slices of the mouse auditory cortex  [通常講演]
    Hiroyuki Kitamura, Jun Nishikawa, Takashi Tateno
    The 43rd Annual Meeting of the Society for Neuroscience (Neuroscience 2013) 2013年11月 ポスター発表
  • ラット聴覚皮質における機能的な異方性：音及び電気刺激に対する神経活動伝搬方向の解析  [通常講演]
    西川淳, 能登将成, 北村宏幸, 舘野高
    電気学会 電子・情報・システム部門大会 2013年09月 ポスター発表
  • 音及び電気刺激が誘発するラット聴覚皮質の神経活動伝搬特性-膜電位感受性色素による光計測  [通常講演]
    西川淳, 能登将成, 舘野高
    第36回 日本神経科学大会 2013年06月 ポスター発表
  • 老化促進マウス（SAM）海馬CA1における時間的・空間的シグナル伝達異常―多電極アレイ計測  [通常講演]
    北村宏幸, 舘野高
    第36回 日本神経科学大会(Neuro 2013) 2013年06月 ポスター発表
  • 情報科学から知る医療応用 大学研究の最前線～最先端の科学と医療を学んでみよう～  [通常講演]
    平田拓, 近野敦, 舘野高
    2013年06月 公開講演，セミナー，チュートリアル，講習，講義等
  • Recording and evaluating electrically evoked responses in hippocampal slices using a planar multielectrode array and standard and inverse current-source destiny analysis  [通常講演]
    H. Kitamura, T. Tateno
    The 42st Annual Meeting of Society of Neuroscience 2012年10月
  • やさしい情報科学とライフイノベーション  [通常講演]
    平田拓, 近野敦, 舘野高
    北海道大学大学院情報科学研究科 公開講座サスティナビリティーウィーク 2012年10月 公開講演，セミナー，チュートリアル，講習，講義等
  • Recording and evaluatng electrically evoked responses in hippocampal slices usind a planar multielectrode array and standard and inverse current-souce destiny analysis  [通常講演]
    H.Kitamura, T.Tateno
    The 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012) 2012年10月 ポスター発表
  • 音情報処理フロントエンド変換機としての圧電素子音響センサと内毛細胞・聴神経複合モデルの統合  [通常講演]
    舘野高, 北村宏幸
    第35回 日本神経科学大会 (Neuro 2012) 2012年09月 ポスター発表
  • 急性海馬スライスにおける局所電気刺激に対する誘発応答の多点記録―標準及び逆電流源密度解析法の評価―  [通常講演]
    北村宏幸, 紺野雄輝, 西川淳
    電気学会 電子・情報・システム部門大会 2012年09月
  • 急性海馬スライスにおける局所電気刺激に対する誘発応答の他店記録―標準及び逆電流源密度解析法の評価―  [通常講演]
    北村宏幸, 紺野雄輝, 西川淳, 舘野高
    電気学会 電子・情報・システム部門大会 2012年09月 ポスター発表
  • Hybrid-type computational modeling of the peripheral auditory system using a piezoelectric acoustic sensor as a front-end transducer for sound processing  [通常講演]
    Takashi Tateno
    8th FENS Forum of Neuroscience 2012年07月 ポスター発表
  • Developing a thin-film electrode system to record in-vivo cortical responses evoke by an artificial peripheral auditory device  [通常講演]
    H. Kitamura, J. Nishikawa, T. Tateno
    MEA Meeting 2012, Reutlingen 2012年07月
  • Developing a thin-film electrode system to record in-vivo cortical responses evoked by an artifical peripheral auditory device  [通常講演]
    H. Kitamura, J.Nishikawa, T.Tatno
    MEA Meeting 2012 8th International Meeting on Substrate-Integrated Microelectrode Arrays 2012年07月 ポスター発表
  • The mechanism of ethanol action on midbrain dopaminergic neuron firing: A dynamic-clamp study of the role of Ih and GABAergic synaptic integration  [通常講演]
    T. Tateno, H.P.C. Robinson
    The 41th Annual Meeting of Society of Neuroscience 2011年11月
  • The mechanism of ethanol action on midbrain dopaminergic neuron firing: A dynamic-clamp study of the role of I_h and GABAergic synaptic integration  [通常講演]
    T. Tateno, H.P.C. Robinson
    The 41st Annual Meeting of Society for Neuroscience (Neuroscience 2011) 2011年11月 口頭発表（一般）
  • 彩都科学体験教室  [通常講演]
    舘野高
    彩都科学体験教室 2011年11月 公開講演，セミナー，チュートリアル，講習，講義等
  • The mechanism of ethanol action on mesencephalic dopaminergic neuron firing: the roles of hyperpolarization-activated inward current and GABAergic synaptic integration,  [通常講演]
    T. Tateno
    The 34th Annual Meeting of the Japan Neuroscience Society (Neuroscience2011) 2011年09月
  • The mechanism of ethanol action on mesencephalic dopaminergic neuron firing: the roles of hyperpolarization-activated inward current and GABAergic synaptic integration,"  [通常講演]
    T. Tateno, H.P.C. Robinson
    第34回 日本神経科学大会 2011年09月 口頭発表（一般）
  • Modeling of peripheral auditory systems using a piezoelectric acoustic sensor  [通常講演]
    T. Tateno
    2011 Annual Conference of Electronics, Information and Systems Society, IEE of Japan 2011年09月
  • 圧電音響センサを応用した聴覚末梢系モデリング  [通常講演]
    舘野高
    電気学会 電子・情報・システム部門大会 2011年09月 口頭発表（一般）
  • The mechanism of ethanol action on mesencephalic dopaminergic neuron firing: the roles of hyperpolarization-activated inward current and GABAergic synaptic integration  [通常講演]
    T. Tateno, H.P.C. Robinson
    第34回日本神経科学大会 2011年09月 口頭発表（一般）
  • Simple dynamical models to understand the mechanisms of drug addiction  [通常講演]
    舘野高
    The 3rd International Conference on Cognitive Neurodynamics 2011年06月 口頭発表（一般）
  • Analysis of ethanol effects on hyperpolarization-activated cation current in rat dopamine neurons and its influence to midbrain local circuits  [通常講演]
    T. Tateno
    The 40th Annual Meeting of Society of Neuroscience 2010年11月
  • 音と耳の織りなす諸現象―聴覚イリュージョンの仕掛けと耳の仕組み－  [通常講演]
    舘野高
    大阪大学大学院基礎工学研究科公開講座 2010年08月 公開講演，セミナー，チュートリアル，講習，講義等
  • Computational modeling of molecular networks underlying postsynaptic plasticity in striatal medium spiny neurons  [通常講演]
    Y. Inui, T. Tateno
    The 7th Forum of European Neuroscience 2010年07月
  • Hybrid-system modeling in electrophysiology - Application of a dynamic-clamp technique  [通常講演]
    舘野高
    Workshop on Computational Neuroscience in Ritsumei University 2010年03月 公開講演，セミナー，チュートリアル，講習，講義等
  • 自己組織型状態空間モデルに基づく蛍光性指示薬濃度と細胞内イオン濃度の統計的推定法について  [通常講演]
    岩橋亮平, 舘野高
    電子情報通信学会信学技法，ニューロコンピューティング 2010年
  • Analysis of an inhibitory and hyperpolarization-activated current (Ih) controlled switch between firing modes in dopaminergic neurons and inhibitory interneurons of rat substantia nigra and their computational modeling,  [通常講演]
    T. Tateno
    The 39th Annual Meeting of Society of Neuroscience 2009年10月
  • Analysis of an inhibitory and hyperpolarization-activated current (Ih) controlled switch between single-spiking and burst firing modes in dopaminergic neurons of rat substantia nigra pars compacta  [通常講演]
    T. Tateno
    The 32 Annual Meeting of the Japan Neuroscience Society (Neuroscience 2009) 2009年09月
  • 黒質緻密部における神経細胞形態の特徴とその受動的膜モデルの一構成法
    河野通太, 舘野高
    電子情報通信学会技術研究報告，ニューロコンピューティング(NC) 2009年
  • 線条体中型有棘細胞の後シナプス可塑性における大規模分子ネットワークからの主要シグナル伝達経路の計算的抽出法について  [通常講演]
    乾洋輔, 舘野高
    電子情報通信学会信学技報，ニューロコンピューティング 2009年
  • マイクロデバイスを応用した神経細胞活動計測  [通常講演]
    舘野高
    数理医療セミナー 2008年12月 公開講演，セミナー，チュートリアル，講習，講義等
  • Firing-mode analysis of neurons in rat substantia nigra pars compacta using a conductance-injection method and conductance-based models  [通常講演]
    T. Tateno
    The 38th Annual Meeting of Society of Neuroscience 2008年11月
  • Firing-mode analysis of neurons in rat substantia nigra pars compacta using a conductance-injection method  [通常講演]
    R. Iwahashi, T. Tateno
    The 31st Annual Meeting of the Japan Neuroscience Society (Neuroscience 2008) 2008年07月
  • 細胞膜の電気的生理学特性に基づくラット黒質緻密部の神経細胞分類について  [通常講演]
    岩橋亮平, 舘野高
    電子情報通信学会技術研究報告，ニューロコンピューティング(NC) 2008年
  • Influence of conductance-input signal on spike generation and stability of rhythmic action-potential oscillations in rat somatosensory fast-spiking neurons  [通常講演]
    T. Tateno
    The 37th Annual Meeting of Society of Neuroscience 2007年11月
  • 神経振動子の位相反応曲線推定法と振動安定性解析  [通常講演]
    阿登正徳, 舘野高
    電子情報通信学会技術研究報告，ニューロコンピューティング(NC) 2007年
  • Influence of conductance input signal and prior activation history on spike generation in rat somatosensory cortical neurons  [通常講演]
    T. Tateno, H.P.C. Robinson
    The 36th Annual Meeting of Society of Neuroscience 2006年10月
  • 大脳皮質神経細胞の振動安定性解析 : 確率的力学系理論に基づくアプローチ  [通常講演]
    舘野高
    電子情報通信学会技術研究報，ニューロコンピューティング 2006年
  • Quantifying oscillatory stability under noisy perturbation in interneurons of rat somatosensory cortex  [通常講演]
    T. Tateno, H.P.C. Robinson
    The 35th Annual Meeting of Society of Neuroscience 2005年11月
  • Random dynamics and stability of cortical neurons  [通常講演]
    T. Tateno, H.P.C. Robinson
    6th International Neural Coding Workshop 2005年09月
  • Spike-time response curves in interneurons of rat samatosensory cortex  [通常講演]
    T. Tateno, H.P.C. Robinson
    Neural Coding 2005, 6th International Neural Coding Workshop 2005年08月
  • Optimization of spike reliability and precision with the level of shunting inhibision in cortical fast-spiking cells  [通常講演]
    T. Tateno, H.P.C. Robinson
    The 4th Forum of European Neuroscience, Lisbon, Portugal 2004年07月
  • Rate coding and spike-timing variability in regular-spiking and fast-spiking cells in rat somatosensory cortex
    T. Tateno, H.P.C. Robinson
    The 34th Annual Meeting of Society of Neuroscience 2004年
  • Class 1 and Class 2 threshold dynamics of neurons in rat somatosensory cortex  [通常講演]
    T. Tateno, A. Harsch, H.P.C. Robinson
    The 33th Annual Meeting of Society of Neuroscience 2003年11月
  • Numerical analysis of stochastic phenomena in one-dimensional two-state systems,  [通常講演]
    T. Tateno
    International conference of noise and fluctuations 2001 2001年10月
  • 周期的なシナプス入力を受ける神経モデル集合の確率共振  [通常講演]
    鶴賀英高, 舘野高, 佐藤俊輔
    電子情報通信学会MBE 2001年
  • 1次元2状態遷移モデルにおける確率現象の数値解析  [通常講演]
    舘野高
    電子情報通信学会研究会，非線形現象(NLP) 2001年
  • Cholinergic Modulation of Network Activity in Cultures of Rat Cortical Neurons  [通常講演]
    T. Tateno, Y. Jimbo
    CREST Workshop on Metalearning and Neuromodulation 2001年
  • 聴覚末梢系計算機モデルを用いた聴覚確率共振現象解析  [通常講演]
    島田知幸, 舘野高, 佐藤俊輔
    第１０回日本神経回路学会 2001年
  • Estimation of propagation delay in neuronal cultures using multi-electrode array recordings  [通常講演]
    T. Tateno, Y. Jimbo
    the International Conference on Dynamical Aspects of Complex Systems from Cells to Brain 2000年
  • 培養神経回路網可塑性の多点計測  [通常講演]
    舘野高, 神保泰彦
    第１０回日本神経回路学会 2000年
  • 細胞外多点計測による培養神経回路網の可塑性の解析  [通常講演]
    舘野高, 神保泰彦, 川名明夫
    生物物理学会第35回年会 1997年
  • 培養神経細胞活動の多点計測とその解析  [通常講演]
    舘野高, 神保泰彦, 川名明夫
    第12回生体生理シンポジウム 1997年
  • 伝送線路型基底膜振動系モデルの問題点について  [通常講演]
    舘野高, 平原達也
    日本音響学会平成8年度秋季研究会 1996年
  • 聴覚末梢系モデルの一構成法  [通常講演]
    舘野高, 平原達也
    日本音響学会平成7年度秋季研究会 1995年

担当経験のある科目（授業）

  • 脳科学研究の展開I（分担）北海道大学
  • 神経制御工学特論北海道大学
  • 神経工学北海道大学
  • 生体工学概論・生体医工学基礎（分担）
  • シミュレーション工学北海道大学
  • 情報エレクトロニクス概論（分担）
  • 全学教育科目「ロボットは感情を持つか」（分担）
  • 情報学Ⅰ北海道大学
  • 生体制御工学特論北海道大学
  • 細胞情報学特論北海道大学
  • 神経情報科学特論北海道大学
  • バイオサイバネティクス北海道大学
  • システムバイオロジー大阪大学

所属学協会

  • 日本数理生物学会   Society for Neuroscience   日本神経科学会   電子情報通信学会   電気学会   システム制御情報学会   老化促進モデルマウス（SAM）学会   

共同研究・競争的資金等の研究課題

  • 日本学術振興会：科学研究費助成事業 挑戦的研究(萌芽)
    研究期間 : 2021年07月 -2024年03月 
    代表者 : 舘野 高
     
    本研究課題では，機械的振動で効率的に中枢神経系を低侵襲的に刺激し，体内臓器や末梢系効果器に神経信号を送信する新技術の開発を目指している．その実現に向けて，脳の局所領域に対し，弱強度の超音波を放射して低侵襲的に神経活動を誘起する小型のデバイスを製作し，その実験系，および，実験プロトコルを開発することを目的としている． 本年度は，本計画期間の初年度であることから，超音波刺激による脳活動誘発に関する基本的な予備実験を行った．まず，先行研究では，機械的振動が脳活動を直接的に誘起するのではなく，聴覚経路を間接的に刺激した後の二次的な神経活動伝播によって生じているとの報告がある．この点を確認するために，聴覚末梢系の神経活動を誘発せずに，超音波刺激によって中枢神経系のみを活動させる刺激条件を広範囲に探索した． また，局所的な脳領域に対して，弱強度の超音波を放射して低侵襲的に神経活動を誘起する小型の刺激デバイスを微細加工技術で製作し，そのデバイスの物理特性を評価する実験系を構築した．具体的には，超音波領域周波数の機械的振動によって，神経細胞活動を誘起するナノメートル厚の圧電材料薄膜と小型ダイアフラムから成るトランスデューサを微細加工技術で製作した．試作に当たっては，事前にその試作物の物理モデルを計算機上に構築し，数値計算によって振動特性を解析した後に，構造を設計して実際にそのデバイスを製作した．これらの結果について国際会議で発表した． さらに，機械的振動が脳活動を誘起する細胞レベルでの作用機序を明らかにする目的で，小型ダイアフラム上に脳組織切片を置き，脳切片底部から超音波を印加する実験系を構築した．加えて，細胞内のカルシウムイオン変動を観察して誘発神経活動の有無を確認するために，カルシウム指示薬に短波長の可視光を照射し，画像をイメージングする計測系を構築した．
  • 日本学術振興会：科学研究費助成事業 基盤研究(B)
    研究期間 : 2019年04月 -2022年03月 
    代表者 : 舘野 高, 神保 泰彦
     
    本研究では低侵襲的に中枢神経系を局所的に磁気刺激して，体内臓器や末梢系効果器に神経信号を正確に送信し，体内合成物質を効果的に放出させる新技術の開発を目指した．そのため，モデル動物の実験用として従来の磁気刺激コイルよりも小型で高効率のコイルを開発した．特に，刺激デバイスとして，ミリサイズからマイクロサイズのコイルを微細加工技術など利用して製作した．また，それらのコイルを用いた磁気刺激で脳内誘発応答の有無を動物実験によって評価した．その結果，当初の設計に沿った磁気刺激デバイスを得ることが可能となった．本研究の結果は，将来的に空間局在性に優れたヒトへの磁気刺激装置の応用開発に寄与するものと思われる．
  • 日本学術振興会：科学研究費助成事業 挑戦的研究(萌芽)
    研究期間 : 2018年06月 -2021年03月 
    代表者 : 舘野 高, 村上 修一
     
    本研究課題では，非侵襲的に中枢神経系を刺激して，中枢系や末梢系に神経信号を正確に送信する新技術の開発を目指している．その実現に向け，ミリサイズの脳領域に対して，超音波（ウルトラサウンド）の機械的な振動を用い，低侵襲的に神経活動を誘起する方法をデバイスレベルから開発することを目的としている．さらに，電気生理学的実験や光学的計測によって，試作デバイスと装置の性能をモデル動物の脳刺激で実験的に評価する．最終的に，ヒトに医療応用するために，空間高分解能の特性をもつ中枢神経系の低侵襲性の刺激システムを構築する基盤技術を確立することを目的としている．研究課題全体では，その実現に向けて，今年度は，次の３つの小課題を実施した．
    【課題１】昨年度の数値計算結果に基づき，微細加工技術を用いて脳刺激に応用する超音波微小デバイス試作し，基本性能を評価した．【課題２】超音波振動に誘発される神経細胞活動の機序解明するために，脳切片の神経活動を計測するin vitro実験系を構築し，神経刺激に適した超音波刺激の物理パラメータを探索した．その結果，超音波刺激で神経細胞の活動誘発が可能な物理パラメータを得ることができた．【課題３】経頭蓋用超音波トランスデューサを用いたin vivo実験系を構築し，脳刺激に適した超音波刺激の物理パラメータを探索した．その結果，超音波刺激で脳活動の誘発が可能な物理パラメータを同様に得ることができた．本年度研究の実施によって，各課題の実験系が構築され，それらを用いて本格的な実験に取り組む準備が整ってきた．また，学会大会や研究会等で，各課題における結果の一部を研究成果として報告した．
  • 日本学術振興会：科学研究費助成事業 基盤研究(B)
    研究期間 : 2015年04月 -2018年03月 
    代表者 : 舘野 高, 神保 泰彦
     

    本研究では，耳鳴りのモデル動物を利用してその生理学的な機序の解明を目指した．また，耳鳴りに関連する神経活動を抑制する脳刺激法の開発に取り組んだ． 近年，耳鳴りは中枢神経系にその疾患原因が深く関与していることが次第に明らかになってきた．本研究課題では，特に，麻酔下の聴覚皮質の脳活動イメージングによって，耳鳴り誘発剤の投与後に特定の周波数に応答する脳のサブ領域が大きく拡張されることが判明した．このような特徴的な神経活動を抑制するため，小型磁気刺激デバイスを開発した．また，本デバイスの脳刺激における有効性が実験的に確認された．今後，耳鳴りモデル動物に適用してその抑制効果をさらに検証する予定である．
  • 日本学術振興会：科学研究費助成事業 基盤研究(C)
    研究期間 : 2015年04月 -2018年03月 
    代表者 : 西川 淳, 舘野 高, 大高 友斗, 橘 唯至, 羽賀 健亮
     
    本研究では，閉ループ電気生理を用いて特定の脳領域における神経応答特性を制御する新規手法を提案した．まず，フラビンタンパク質蛍光イメージングと局所電場電位計測を用いて齧歯類聴覚皮質における各サブ領域および層における時間周波数受容野(STRF)を体系的に調べた．特に，覚醒自由行動下のマウス聴覚皮質では，異なる２つの行動文脈においてSTRFの特性が動的に遷移することを明らかにした．得られた知見をもとに，各サブ領域および層にまたがる多点シリコン電極を刺入し，聴覚応答を計測しながらSTRFを実時間で推定し，その結果に応じて特定のチャンネルを多点電流刺激できるシステムを構築することに成功した．
  • 日本学術振興会：科学研究費助成事業 挑戦的萌芽研究
    研究期間 : 2015年04月 -2018年03月 
    代表者 : 舘野 高, 村上 修一, 佐藤 和郎
     

    本研究では，生体内で生成される数10 mVの微小な電位を利用して，体内埋め込み機器とその蓄電系に電力を供給する非常用体内システムの基盤技術開発を目的とした．また，技術応用として，生体の組織・細胞内電位を実時間で計測し，その電圧源を用いて他の機器に電力を供給する技術の開発を目指した．特に，本研究では，開発したシステムを応用する対象として神経細胞インターフェースと音響センサを具体的に取り上げ，昇圧コンバータ回路を用いて生体内の微小電位を高電位に昇圧し，それらの機器に電力供給する基礎的な技術を開発した．その結果，数10 mVの直流電圧成分を数Vに昇圧し，電子機器を駆動する基盤的な技術を開発できた．
  • 聴覚中枢神経マイクロ・インプラントにおける システム・インテグレーションの基盤形成
    内閣府：次世代・最先端研究開発支援プロジェクト
    研究期間 : 2010年02月 -2014年03月 
    代表者 : 舘野高
  • 神経幹細胞の膜動態を誘導するリバース・エンジニアリング法の開発
    科学研究費補助金 萌芽研究
    研究期間 : 2008年04月 -2013年03月 
    代表者 : 舘野高
  • 次世代人工感覚器の為のマイクロデバイス・システムインテグレーションの基盤形成
    科学研究費補助金 基盤研究(B)
    研究期間 : 2009年04月 -2012年03月 
    代表者 : 舘野高
  • 大脳基底核回路網のハイブリッドシステムモデリング
    JSTさきがけ：JSTさきがけ研究
    研究期間 : 2007年04月 -2012年03月 
    代表者 : 舘野高
  • MEMS/NEMS技術を用いた人工感覚上皮の開発に関する研究
    厚生労働省：厚生労働科学研究費補助金
    研究期間 : 2010年04月 -2011年03月 
    代表者 : 舘野高
  • 発現遺伝子と細胞動態の相関情報から探る細胞集団の同期的活動生起と崩壊の統合的理解
    科研費新学術領域研究 公募研究
    研究期間 : 2010年04月 -2011年03月 
    代表者 : 舘野高
  • ナノテクノロジー，神経生理学および臨床医学を融合した細胞機能診断技術の創成
    大阪大学基礎工学研究科：「未来研究ラボシステム」助成
    研究期間 : 2007年04月 -2010年03月 
    代表者 : 舘野高
  • ダイナミッククランプ法による神経回路網ハイブリッドシステムの構築と動的安定性解析
    科学研究費補助金 萌芽研究
    研究期間 : 2006年04月 -2009年03月 
    代表者 : 舘野高
  • 日本学術振興会：科学研究費助成事業
    研究期間 : 2007年 -2009年 
    代表者 : 野村 泰伸, 舘野 高, 中村 亨, 浅井 義之, 野村 国彦, 東 道年, 田坂 優一, 鈴木 康之, 河津 俊宏, 竹内 康浩, 小松 一貴
     
    ヒトの身体運動,すなわち運動学的計測データ,およびそれに伴う筋電図などの動力学的変量の計測データを,身体運動の数理モデルとリンクさせることで,階層的に記述することが可能なデータ構造をXMLに基づく標準様式として策定した.ヒト立位および歩行運動計測系を構築し,ヒト静止立位および二足歩行に関する仮説検証型の実験を実施した.特に,ヒト静止立位の神経制御に関して,間欠制御仮説という新仮説を提案した.これらの実験で得られた計測データを,上記標準様式に基づきデータベース化し,第三者利用が可能な形式で公開した.
  • デジタルプロセッサと神経細胞のハイブリッドシステム相互作用から理解する脳の可塑的潜在能力
    大川情報通信：大川情報通信基金助成金
    研究期間 : 2007年04月 -2008年03月 
    代表者 : 舘野高
  • 量子ドットプローブを用いたパーキンソン病関連タンパク質の可視化とドーパミン細胞の電気的活動計測
    村田財団学術振興財団：村田財団学術振興財団助成金
    研究期間 : 2007年04月 -2008年03月 
    代表者 : 舘野高
  • 音環境の情報処理系としての聴覚末梢・中枢系の統合的理解の研究
    科学研究費補助金，基盤研究(B)
    研究期間 : 2006年04月 -2008年03月 
    代表者 : 舘野高
  • 多電極アレイ記録システムを用いた聴覚中枢系における神経伝達物質による活動修飾の可視化に関する研究
    千里ライフサイエンス振興財団：千里ライフサイエンス振興財団助成金
    研究期間 : 2006年03月 -2007年04月 
    代表者 : 舘野高
  • 日本学術振興会：科学研究費助成事業
    研究期間 : 2005年 -2006年 
    代表者 : 野村 泰伸, 館野 高, 下川 哲也
     
    本研究の目的は,興奮性細胞膜のチャネル構造とその変化と膜電位動態の関連を,マルチエージェント型膜動態シミュレーションモデルを用いて明らかにすることであった.この目的に対する萌芽研究として,ヤリイカ巨大軸索のモデル化を試行した.これは,チャネルタンパク,イオン,イオン交換ポンプ,脂質二重膜をエージェント(計算機内オブジェクト)としモデル化し,これら多数のエージェントの複合体で膜モデルを構成するための基盤創成となる.この基盤が実現できれば,各エージェントが3次元構造を有し,物理法則に従い自律的に自身の構造や位置を更新する細胞動態シミュレーションが可能になる.最終年度である本年度は,種々のイオンチャネルの構造とその変化の動態をオブジェクトとしてモデル化する作業を効率的に実施できるシステム開発を実施し,それを用いて詳細な形態・構造を取り入れた細胞膜の構造・動態モデルのシミュレーションを実施した.実際にシミュレーションを実施したところ予想以上に膨大な計算時間を要することが明らかになったため,細胞膜全体の動態シミュレーションは今後の課題として残し,シングルチャネル(ポタシウムチャネル)動態のみを考慮した.具体的には,イオンチャネルやイオンの3次元的位置の状態更新を0.1ナノ秒という荒い時間ステップで実施した.ここまでの成果はIEEE-EMBSのannual conferenceで発表した.しかしながら,対象をシングルチャネルに限定した場合でも,活動電位生成の時間スケールである数百ミリ秒のシミュレーションには膨大な計算時間を要する.そこで,動態シミュレーションをPCクラスタを用いた並列計算で実現することを試み,計算の高速化を図った.このように,単一細胞膜の動態シミュレーションの実現に繋がるシミュレーション基盤を構築することができた.
  • 大脳皮質神経活動のマルチスケーリング現象の測定と解析
    日本学術振興会海外特別研究員
    研究期間 : 2002年09月 -2004年08月 
    代表者 : 舘野高
  • 聴覚情報処理における背景雑音が信号検出に果たす機能的役割
    科学研究費補助金，基盤研究(B)
    研究期間 : 2000年04月 -2002年03月 
    代表者 : 舘野高
  • 日本学術振興会：科学研究費助成事業
    研究期間 : 2001年 -2002年 
    代表者 : 野村 泰伸, 牧川 方昭, 舘野 高, 佐藤 俊輔
     
    ヒトの二足歩行運動は,ヒトの筋骨格系を脳神経系による制御と床反力を介した外界との相互作用により,動的安定性を確保している.このとき脳神経系がどのような方略で動的安定性を維持しているかを2つの視点から検討した.1つ目は,定常歩行中の被験者に転倒を引き起こすようなインパルス状外乱を加え,それに対する運動応答,特に歩行リズムの変調(位相リセット)が転倒を回避するのにどのような役割を果たしているかを,歩行の非線形力学系モデルのダイナミクスと実験結果の比較から明らかにした.特に,実験的に計測された外乱のタイミング依存的な応答は,非線形力学系のダイナミクスの意味でも動的に安定な歩行状態を維持する目的にとって最適化されたものである可能性を示唆した.もう1つは,パーキンソン病患者を被験者とした自転車漕ぎ実験における左右脚のペダリングリズムと運動パターンを生成する神経回路の数理モデルのダイナミクスの比較研究である.ここでは左右のペダルが独立に回転する特殊な自転車を用いているが,健常被験者は通常の自転車と同様な左右逆相の周期的ペダリングを行う.しかし協調運動に失調が現れるパーキンソン病患者では,左右のペダリングパターンが逆相からズレて非定常で不規則になる.この現象を上位中枢からトニックな入力を受ける相互抑制型非線形結合2振動子モデルで再現し,上位中枢からの入力の大きさや2つの振動子への入力の大きさの非対称性に依存して,健常者では動的に安定な逆相振動が不安定化して発生しうることを示した.以上の結果は,ヒトの歩行運動の動的安定性を維持するためには,脳が身体および脊髄神経系が示す自律的ダイナミクスを考慮した高度な制御を行わなければならいことを示唆している.
  • 日本学術振興会：科学研究費助成事業
    研究期間 : 1999年 -1999年 
    代表者 : 佐藤 俊輔, 館野 高, PAKDAMAN Khashayar, 野村 泰伸
     
    生体信号の解釈を容易にするために,2つの方向への研究の拡張がなされてきた.1つは,時間方向である.たとえば,長時間計測が可能になり,生体信号が決して定常ではないこと,したがって,それを生成する生体は時不変ではなく、時変であることがわかってきた.もう1つは信号解析に非線形力学系の考え方が導入されたことであある.本研究課題ではまず,第1の方向の研究として,「時系列から分岐構造の解析」というテーマをあつかった.制御可能なパラメータを持つ力学系が与えられたとする.その力学系のそのパラメータに関する分岐構造と同様な分岐構造を持つパラメータ化された関数(予測関数)を種々の方法で求めた.この関数のパラメータ空間の領域(射影領域)のパラメータ値に対して,この関数(モデル)のダイナミックスは与えられた力学系のそれと同じである.いいかえれば,この領域でモデルの分岐構造を与えられた力学系の分岐構造とみなせる。このことを利用して,未知の力学系が生成した時系列からその力学系の分岐構造を再構成した. 以上の成果をふまえ,心循環系,内分泌系の生理学の知識を総合してホメオダイナミクスの概念について検討した.複雑なダイナミクスをもつ生体の部分システムは相互作用して全体で安定性を保っている.ホメオダイナミクスを実現するためには生体システムが非線系力学系として機能していることを示唆する.このような例をヒトの二足歩行の動力学と中枢制御機構にもとめ,考察した.

産業財産権

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  • 特願PCT/JP2011/052164:電気生理測定装置及び方法  2011年02月02日
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    国際出願
  • 特願2010-032646:電気生理測定装置及び方法  2010年02月07日
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