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Yamasaki Masahiro
| Faculty of Veterinary Medicine Veterinary Medicine Clinical Sciences | Professor |
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■ Papers- Prognostic Value of Intrarenal Venous Flow Analysis Using Pulsed-Wave Doppler Ultrasonography in Dogs with Myxomatous Mitral Valve Disease
Tomoya Morita; Hiroki Terukina; Masahiro Yamasaki
Journal of Veterinary Internal Medicine, 39, 6, Oxford University Press (OUP), 01 Nov. 2025, [Peer-reviewed], [Last author]
Scientific journal, Abstract
Background
The predictive value of intrarenal Doppler ultrasonography (IRD) analysis using pulsed-wave Doppler for survival in dogs with myxomatous mitral valve disease (MMVD) remains unknown.
Hypothesis/Objectives
Impaired IRD indices, such as a high venous impedance index (VII), are associated with a short survival time in dogs with MMVD.
Animals
Seventy-one client-owned dogs with MMVD.
Methods
Prospective cohort study. Dogs diagnosed with various stages of MMVD between July 2019 and February 2024 were enrolled. Echocardiography and an IRD analysis were performed. Resistance index and VII were estimated using the following formula: (maximum flow velocity—minimum flow velocity)/maximum flow velocity from renal interlobar arteries and veins, respectively. Intrarenal venous flow waveforms were categorized into continuous and discontinuous patterns. Discontinuous IRVF pattern is defined as a minimum velocity of 0. The primary endpoint was defined as a composite of cardiac- and renal-related death.
Results
During the follow-up period, 18 dogs met the primary endpoint. A multivariable Cox proportional hazard analysis adjusted for the Mitral INsufficiency Echocardiographic score and plasma creatinine concentrations identified VII > 0.37 (hazard ratio, at least 4.62; 95% CI, 1.47–14.56) and discontinuous intrarenal venous pattern (hazard ratio, at least 3.62; 95% CI, 1.22–10.73) as an independent predictors of cardiac- and renal-related death. No association between resistance index and outcomes was observed in the multivariable analysis.
Conclusions and Clinical Importance
Worse outcomes in dogs with MMVD could be predicted by an intrarenal venous flow analysis. - Analysis of gene expression of <i>Babesia gibsoni</i> cultured with diminazene aceturate using RNA sequencing
Nami MATSUDA; Minori ITO; Yuka NUKADA; Miyuki TOYOMA; Kazuya NAGAI; Tomoki MOTEGI; Tomoya MORITA; Masahiro YAMASAKI
Journal of Veterinary Medical Science, 87, 2, 181, 188, Japanese Society of Veterinary Science, 2025, [Peer-reviewed], [Corresponding author]
English, Scientific journal - Computed tomographic characteristics of testicular teratoma in a cat
Takahiro Nagumo; Rika Yoshii; Yuji Uzuka; Yuki Hoshino; Kohei Nakata; Masaaki Katayama; Masahiro Yamasaki
Veterinary Radiology & Ultrasound, 65, 5, 496, 500, Wiley, 06 May 2024, [Peer-reviewed]
English, Scientific journal, Abstract
A 5‐year‐old intact male mixed‐breed cat weighing 4.5 kg was referred to our hospital with a left testicular mass. CT revealed mild heterogeneous contrast enhancement and calcification in the testicular mass. A well‐defined, contrast‐enhancing, multiloculated mass with fluid‐filled areas was extended from the testicular mass in the scrotum to the caudal aspect of the left kidney. The abdominal mass extended to the right crus of the diaphragm, and the gastrointestinal tract was compressed dorsally. Histopathology was consistent with teratoma. Characteristic CT findings in a feline testicular teratoma may include calcification and cystic areas. - A Case Study of Methemoglobinemia in a Toy Poodle
Kazuya NAKAYAMA; Masahiro YAMASAKI; Tomoki SAITO; Yuji FUJII; Takashi MORI
Journal of the Japan Veterinary Medical Association, 77, 12, e167, e172, Japan Veterinary Medical Association, 2024, [Peer-reviewed]
Japanese, Scientific journal - Suspected renal interstitial cell tumor causing polycythemia in two dogs
Kaori IDE; Masaaki KATAYAMA; Ikki MITSUI; Hiroshi SATOH; Ryuji FUKUSHIMA; Yoshio YAMAMOTO; Masahiro YAMASAKI
Journal of Veterinary Medical Science, 86, 4, 368, 373, Japanese Society of Veterinary Science, 2024, [Peer-reviewed]
Scientific journal - The role of heat shock protein 90 in the proliferation of Babesia gibsoni in vitro.
Hiroka Tsutsumi; Moeko Abe; Naohiro Uchida; Mitsuyoshi Takiguchi; Masahiro Yamasaki
Experimental parasitology, 251, 108567, 108567, Aug. 2023, [International Magazine]
English, Scientific journal, The present study investigated the role of heat shock protein 90 (HSP90) in the proliferation and survival of Babesia gibsoni in vitro. To detect the effect on the entry of B. gibsoni into host erythrocytes, the parasite was incubated with an antibody against B. gibsoni HSP90 (BgHSP90) for 24 h. The results of this experiment demonstrated that both the incorporation of [3H]hypoxanthine into the nucleic acids of B. gibsoni and the number of parasites were not altered, indicating that an anti-BgHSP90 antibody did not directly inhibit the entry of the parasite into erythrocytes. Moreover, two HSP90 inhibitors, geldanamycin (GA) and tanespimycin (17-AAG), were used to evaluate the function of BgHSP90. GA and 17-AAG decreased both the incorporation of [3H]hypoxanthine and the number of infected erythrocytes, suggesting that BgHSP90 plays important roles in DNA synthesis and the proliferation of B. gibsoni. The effect of 17-AAG on the parasites was weaker than that of GA. Additionally, the effect of GA on the survival and superoxide generation of canine neutrophils was assessed. The survival of canine neutrophils was not affected. The superoxide generation was strongly suppressed by GA. This result indicated that GA inhibited the function of canine neutrophils. Additional studies are necessary to elucidate the role of BgHSP90 in the proliferation of the parasite. - Effects of Alfaxalone on the Induction and Maintenance of Total Intravenous Anesthesia in Gentoo Penguins (Pygoscelis papua)
Koji Ono; Masahiro Yamasaki; Toshihiro Ichijo; Hiroshi Satoh
Journal of Avian Medicine and Surgery, 37, 1, Association of Avian Veterinarians (AAV), 21 Jun. 2023, [Peer-reviewed]
English, Scientific journal - Three cases of canine babesiosis caused by Babesia odocoilei-like parasites in Japan
Masahiro Yamasaki; Yuka Nukada; Minori Ito; Naohiro Uchida; Aiko Iguchi; Hisashi Inokuma
Parasitology International, 102384, 102384, Elsevier BV, May 2021
Scientific journal - Repeatable and objective method for evaluating angiogenesis using real‐time RT‐PCR of endoglin expression in canine tumours
Mayu Kimura; Masahiro Yamasaki; Hiroshi Satoh; Naohiro Uchida
Veterinary and Comparative Oncology, 19, 1, 34, 43, Wiley, Mar. 2021, [Peer-reviewed]
Scientific journal - Reduced expression levels of heat shock protein 90 in a diminazene aceturate-resistant Babesia gibsoni isolate.
Masahiro Yamasaki; Natsuki Idaka; Moeko Abe; Mitsuyoshi Takiguchi
Experimental parasitology, 221, 108050, 108050, Feb. 2021, [International Magazine]
English, Scientific journal, Heat shock protein 90 (HSP90) is a molecular chaperon and an essential component for stage differentiation and intracellular growth inside the host cells of many protozoans. HSP90 of Babesia gibsoni (BgHSP90) was suggested to function in the development of diminazene aceturate (DA)-resistance. Therefore, we examined the expression level of BgHSP90 in a DA-resistant B. gibsoni isolate. Transcription of the BgHSP90 gene in the DA-resistant isolate and wild-type B. gibsoni was assessed by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). As a result, the copy number and relative amount of BgHSP90 transcripts in the DA-resistant isolate were significantly lower than those in the wild-type. Moreover, a rabbit anti-recombinant BgHSP90 antibody was developed, and the protein synthesis of BgHSP90 in the DA-resistant isolate was compared with that in the wild-type by Western blot analysis and indirect fluorescence assay. There was significantly less BgHSP90 protein than in the wild-type. Additionally, the relative intensity of BgHSP70 in DA-resistant isolate was also lower than that in the wild-type. This suggested that the expression of BgHSP90 and BgHSP70 in the DA-resistant B. gibsoni isolate was suppressed and that the reduced amount of BgHSP90 and BgHSP70 might cause the weak proliferation of the DA-resistant isolate. Further studies are necessary to elucidate the function of BgHSP90. - Intracellular diminazene aceturate content and adenosine incorporation in diminazene aceturate-resistant Babesia gibsoni isolate in vitro
Masahiro Yamasaki; Nao Watanabe; Natsuki Idaka; Tohru Yamamori; Ken-ichi Otsuguro; Naohiro Uchida; Aiko Iguchi; Hiroshi Ohta; Mitsuyoshi Takiguchi
EXPERIMENTAL PARASITOLOGY, 183, 92, 98, Dec. 2017, [Peer-reviewed]
English, Scientific journal - Assessment of contrast-enhanced ultrasonography of the hepatic vein for detection of hemodynamic changes associated with experimentally induced portal hypertension in dogs
Keitaro Morishita; Akira Hiramoto; Asuka Michishita; Satoshi Takagi; Yuki Hoshino; Takaharu Itami; Sue Yee Lim; Tatsuyuki Osuga; Sayuri Nakamura; Kenji Ochiai; Kensuke Nakamura; Hiroshi Ohta; Masahiro Yamasaki; Mitsuyoshi Takiguchi
AMERICAN JOURNAL OF VETERINARY RESEARCH, 78, 4, 465, 471, Apr. 2017, [Peer-reviewed]
English, Scientific journal - Contrast-enhanced ultrasonography of the hepatic vein in normal dogs.
Morishita K; Hiramoto A; Osuga T; Lim SY; Khoirun N; Sasaki N; Nakamura K; Ohta H; Yamasaki M; Takiguchi M
The Journal of veterinary medical science, 78, 12, 1753, 1758, Jan. 2017, [Peer-reviewed] - Molecular cloning, phylogenetic analysis and heat shock response of Babesia gibsoni heat shock protein 90.
Masahiro Yamasaki; Yoshihiro Tsuboi; Yusuke Taniyama; Naohiro Uchida; Reeko Sato; Kensuke Nakamura; Hiroshi Ohta; Mitsuyoshi Takiguchi
The Journal of veterinary medical science, 78, 8, 1355, 60, 01 Sep. 2016, [Peer-reviewed], [Domestic magazines]
English, The Babesia gibsoni heat shock protein 90 (BgHSP90) gene was cloned and sequenced. The length of the gene was 2,610 bp with two introns. This gene was amplified from cDNA corresponding to full length coding sequence (CDS) with an open reading frame of 2,148 bp. A phylogenetic analysis of the CDS of HSP90 gene showed that B. gibsoni was most closely related to B. bovis and Babesia sp. BQ1/Lintan and lies within a phylogenetic cluster of protozoa. Moreover, mRNA transcription profile for BgHSP90 exposed to high temperature were examined by quantitative real-time reverse transcription-polymerase chain reaction. BgHSP90 levels were elevated when the parasites were incubated at 43°C for 1 hr. - Hypercalcemia in a Dog with Chronic Ingestion of Maxacalcitol Ointment.
Nakamura K; Tohyama N; Yamasaki M; Ohta H; Morishita K; Takiguchi M
Journal of the American Animal Hospital Association, 52, 4, 256, 258, Jul. 2016, [Peer-reviewed] - Quantitative contrast-enhanced ultrasonographic assessment of naturally occurring pancreatitis in dogs.
Lim SY; Nakamura K; Morishita K; Sasaki N; Murakami M; Osuga T; Yokoyama N; Ohta H; Yamasaki M; Takiguchi M
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 29, 1, 71, 78, Jan. 2015, [Peer-reviewed] - Contrast-enhanced ultrasonographic findings in three dogs with pancreatic insulinoma.
Nakamura K; Lim SY; Ochiai K; Yamasaki M; Ohta H; Morishita K; Takagi S; Takiguchi M
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 56, 1, 55, 62, Jan. 2015, [Peer-reviewed] - In vitro and in vivo safety and efficacy Studies of amphotericin B on Babesia gibsoni
Masahiro Yamasaki; Eriko Harada; Yu Tamura; Sue Yee Lim; Tatsuyuki Ohsuga; Nozomu Yokoyama; Keitaro Morishita; Kensuke Nakamura; Hiroshi Ohta; Mitsuyoshi Takiguchi
VETERINARY PARASITOLOGY, 205, 3-4, 424, 433, Oct. 2014, [Peer-reviewed]
English, Scientific journal - Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis
Yu Tamura; Hiroshi Ohta; Nozomu Yokoyama; Sue Yee Lim; Tatsuyuki Osuga; Keitaro Morishita; Kensuke Nakamura; Masahiro Yamasaki; Mitsuyoshi Takiguchi
JOURNAL OF VETERINARY MEDICAL SCIENCE, 76, 10, 1407, 1410, Oct. 2014, [Peer-reviewed]
English, Scientific journal - Case report: Protein-losing enteropathy caused by Mesocestoides vogae (syn. M. corti) in a dog
Yu Tamura; Hiroshi Ohta; Takuya Kashiide; Jun Matsumoto; Tatsuya Sakurai; Nozomu Yokoyama; Keitaro Morishita; Kensuke Nakamura; Masahiro Yamasaki; Mitsuyoshi Takiguchi
VETERINARY PARASITOLOGY, 205, 1-2, 412, 415, Sep. 2014, [Peer-reviewed]
English, Scientific journal - Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease
Hiroshi Ohta; Yuji Sunden; Nozomu Yokoyama; Tatsuyuki Osuga; Sue Yee Lim; Yu Tamura; Keitaro Morishita; Kensuke Nakamura; Masahiro Yamasaki; Mitsuyoshi Takiguchi
AMERICAN JOURNAL OF VETERINARY RESEARCH, 75, 8, 746, 751, Aug. 2014, [Peer-reviewed]
English, Scientific journal - Qualitative and Quantitative Contrast-Enhanced Ultrasonographic Assessment of Cerulein-Induced Acute Pancreatitis in Dogs
S. Y. Lim; K. Nakamura; K. Morishita; N. Sasaki; M. Murakami; T. Osuga; H. Ohta; M. Yamasaki; M. Takiguchi
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28, 2, 496, 503, Mar. 2014, [Peer-reviewed]
English, Scientific journal - CD4(+) T Cell Cytokine Gene and Protein Expression in Duodenal Mucosa of Dogs with Inflammatory Bowel Disease
Hiroshi Ohta; Kanae Takada; Yuji Sunden; Yu Tamura; Tatsuyuki Osuga; Sue Yee Lim; Masahiro Murakami; Noboru Sasaki; Bandula Kumara Wickramasekara Rajapakshage; Kensuke Nakamura; Masahiro Yamasaki; Mitsuyoshi Takiguchi
JOURNAL OF VETERINARY MEDICAL SCIENCE, 76, 3, 409, 414, Mar. 2014, [Peer-reviewed]
English, Scientific journal - Ultrasound image-guided therapy enhances antitumor effect of cisplatin.
Noboru Sasaki; Nobuki Kudo; Kensuke Nakamura; Sue Yee Lim; Masahiro Murakami; W R Bandula Kumara; Yu Tamura; Hiroshi Ohta; Masahiro Yamasaki; Mitsuyoshi Takiguchi
Journal of medical ultrasonics (2001), 41, 1, 11, 21, Jan. 2014, [Peer-reviewed], [Domestic magazines]
English, PURPOSE: The aim of this study was to clarify whether ultrasound image-guided cisplatin delivery with an intratumor microbubble injection enhances the antitumor effect in a xenograft mouse model. METHODS: Canine thyroid adenocarcinoma cells were used for all experiments. Before in vivo experiments, the cisplatin and microbubble concentration and ultrasound exposure time were optimized in vitro. For in vivo experiments, cells were implanted into the back of nude mice. Observed by a diagnostic ultrasound machine, a mixture of cisplatin and ultrasound contrast agent, Sonazoid, microbubbles was injected directly into tumors. The amount of injected cisplatin and microbubbles was 1 μg/tumor and 1.2 × 10(7) microbubbles/tumor, respectively, with a total injected volume of 20 μl. Using the same diagnostic machine, tumors were exposed to ultrasound for 15 s. The treatment was repeated four times. RESULTS: The combination of cisplatin, microbubbles, and ultrasound significantly delayed tumor growth as compared with no treatment (after 18 days, 157 ± 55 vs. 398 ± 49 mm(3), P = 0.049). Neither cisplatin alone nor the combination of cisplatin and ultrasound delayed tumor growth. The treatment did not decrease the body weight of mice. CONCLUSION: Ultrasound image-guided anticancer drug delivery may enhance the antitumor effects of drugs without obvious side effects. - Prognostic Value of Left Atrial Function in Dogs with Chronic Mitral Valvular Heart Disease
Nakamura K; Osuga T; Morishita K; Suzuki S; Morita T; Yokoyama N; Ohta H; Yamasaki M; Takiguchi M
Journal of Veterinary Internal Medicine, 28, 6, 1746, 1752, 2014, [Peer-reviewed] - Qualitative and quantitative contrast enhanced ultrasonography of the pancreas using bolus injection and continuous infusion methods in normal dogs.
Lim SY; Nakamura K; Morishita K; Sasaki N; Murakami M; Osuga T; Ohta H; Yamasaki M; Takiguchi M
The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 75, 12, 1601, 1607, Dec. 2013, [Peer-reviewed] - Markedly increased expression of interleukin-8 in the colorectal mucosa of inflammatory colorectal polyps in miniature dachshunds.
Tamura Y; Ohta H; Torisu S; Yuki M; Yokoyama N; Murakami M; Lim SY; Osuga T; Morishita K; Nakamura K; Yamasaki M; Takiguchi M
Veterinary immunology and immunopathology, 156, 1-2, 32, 42, Nov. 2013, [Peer-reviewed] - LC-MS/MS analysis of canine lipoproteins fractionated using the ultracentrifugation-precipitation method.
Suto A; Yamasaki M; Takasaki Y; Fujita Y; Abe R; Shimizu H; Ohta H; Takiguchi M
The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 75, 1471, 1477, 11, Nov. 2013, [Peer-reviewed] - Expression of CD4+ T cell cytokine genes in the colorectal mucosa of inflammatory colorectal polyps in miniature dachshunds.
Ohta H; Takada K; Torisu S; Yuki M; Tamura Y; Yokoyama N; Osuga T; Lim SY; Murakami M; Sasaki N; Nakamura K; Yamasaki M; Takiguchi M
Veterinary immunology and immunopathology, 155, 4, 259, 263, Oct. 2013, [Peer-reviewed] - Increased intratumoral fluorothymidine uptake levels following multikinase inhibitor sorafenib treatment in a human renal cell carcinoma xenograft model
Masahiro Murakami; Songji Zhao; Yan Zhao; Wenwen Yu; Chowdhury Nusrat Fatema; Ken-Ichi Nishijima; Masahiro Yamasaki; Mitsuyoshi Takiguchi; Nagara Tamaki; Yuji Kuge
Oncology Letters, 6, 3, 667, 672, Sep. 2013, [Peer-reviewed]
English, Scientific journal - Repeatability and reproducibility of measurements obtained via two-dimensional speckle tracking echocardiography of the left atrium and time-left atrial area curve analysis in healthy dogs.
Osuga T; Nakamura K; Lim SY; Tamura Y; Kumara WR; Murakami M; Sasaki N; Morishita K; Ohta H; Yamasaki M; Takiguchi M
American journal of veterinary research, 74, 6, 864, 869, Jun. 2013, [Peer-reviewed] - Involvement of Mitochondrial Genes of Babesia gibsoni in Resistance to Diminazene Aceturate
Bandula Kumara Wickramasekara Rajapakshage; Masahiro Yamasaki; Shiang-Jyi Hwang; Noboru Sasaki; Masahiro Murakami; Yu Tamura; Sue Yee Lim; Kensuke Nakamura; Hiroshi Ohta; Mitsuyoshi Takiguchi
JOURNAL OF VETERINARY MEDICAL SCIENCE, 74, 9, 1139, 1148, Sep. 2012, [Peer-reviewed]
English, Scientific journal - Bilateral Segmental Aplasia with Unilateral Uterine Horn Torsion in a Pomeranian Bitch
Kensuke Nakamura; Masahiro Yamasaki; Tomohiro Osaki; Hiroshi Ohta; Noboru Sasaki; Keisuke Aoshima; Takashi Kimura; Mitsuyoshi Takiguchi
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 48, 5, 327, 330, Sep. 2012, [Peer-reviewed]
English, Scientific journal - Analysis of energy generation and glycolysis pathway in diminazene aceturate-resistant Babesia gibsoni isolate in vitro
Bandula Kumara Wickramasekara Rajapakshage; Masahiro Yamasaki; Masahiro Murakami; Yu Tamura; Sue Yee Lim; Tatsuyuki Osuga; Noboru Sasaki; Kensuke Nakamura; Hiroshi Ohta; Mitsuyoshi Takiguchi
JAPANESE JOURNAL OF VETERINARY RESEARCH, 60, 2-3, 51, 61, Aug. 2012, [Peer-reviewed]
English, Scientific journal - Intestinal Tritrichomonas suis (=T. foetus) Infection in Japanese Cats
Junko Doi; Junichi Hirota; Akihiko Morita; Kanae Fukushima; Hiromi Kamijyo; Hiroshi Ohta; Masahiro Yamasaki; Toru Takahashi; Ken Katakura; Yuzaburo Oku
JOURNAL OF VETERINARY MEDICAL SCIENCE, 74, 4, 413, 417, Apr. 2012, [Peer-reviewed]
English, Scientific journal - ACTIVATION OF MICROBUBBLES BY SHORT-PULSED ULTRASOUND ENHANCES THE CYTOTOXIC EFFECT OF CIS-DIAMMINEDICHLOROPLATINUM (II) IN A CANINE THYROID ADENOCARCINOMA CELL LINE IN VITRO
Noboru Sasaki; Nobuki Kudo; Kensuke Nakamura; Sue Yee Lim; Masahiro Murakami; W. R. Bandula Kumara; Yu Tamura; Hiroshi Ohta; Masahiro Yamasaki; Mitsuyoshi Takiguchi
ULTRASOUND IN MEDICINE AND BIOLOGY, 38, 1, 109, 118, Jan. 2012, [Peer-reviewed]
English, Scientific journal - Enhanced Cytotoxic Effect of Cisplatin Using Diagnostic Ultrasound and Microbubbles In Vitro
Sasaki Noboru; Nakamura Kensuke; Murakami Masahiro; Lim Sue Yee; Ohta Hiroshi; Yamasaki Masahiro; Takiguchi Mitsuyoshi
11TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND, 1481, 307, 310, 2012, [Peer-reviewed] - Effects and Mechanisms of Action of Polyene Macrolide Antibiotic Nystatin on Babesia gibsoni In Vitro
Masahiro Yamasaki; Norihisa Tamura; Kensuke Nakamura; Noboru Sasaki; Masahiro Murakami; Wickramasekara Rajapakshage; Bandula Kumara; Yu Tamura; Sue Yee Lim; Hiroshi Ohta; Mitsuyoshi Takiguchi
JOURNAL OF PARASITOLOGY, 97, 6, 1190, 1192, Dec. 2011, [Peer-reviewed]
English, Scientific journal - Rapid detection of GM1 ganglioside in cerebrospinal fluid in dogs with GM1 gangliosidosis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry
Hiroyuki Satoh; Toyofumi Yamauchi; Masahiro Yamasaki; Yoshimitsu Maede; Akira Yabuki; Hye-Sook Chang; Taketoshi Asanuma; Osamu Yamato
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 23, 6, 1202, 1207, Nov. 2011, [Peer-reviewed]
English, Scientific journal - Effects of sildenafil citrate on five dogs with Eisenmenger's syndrome
K. Nakamura; M. Yamasaki; H. Ohta; N. Sasaki; M. Murakami; W. R. Bandula Kumara; M. Takiguchi
JOURNAL OF SMALL ANIMAL PRACTICE, 52, 11, 595, 598, Nov. 2011, [Peer-reviewed]
English, Scientific journal - Pathological correlations between podocyte injuries and renal functions in canine and feline chronic kidney diseases.
Ichii O; Yabuki A; Sasaki N; Otsuka S; Ohta H; Yamasaki M; Takiguchi M; Namiki Y; Hashimoto Y; Endoh D; Kon Y
Histology and histopathology, 26, 10, 1243, 1255, Oct. 2011, [Peer-reviewed] - Two dogs having infiltration of eosinophils into the subcorneal layer and dermis according to dermatohistopathology.
Chiba, E; Yamasaki, M; Ohta, H; Nakamura, K; Sasaki, N; Murakami, M; Tamura, Y; Yee, L-S; Bandula Kumara; W. R; Honda, H; Nasuno, T; Ochiai, K; Takiguchi, M
Jpn. J. Vet. Dermatol., 17, 3, 177, 182, Sep. 2011, [Peer-reviewed] - Detection of anti-Babesia gibsoni heat shock protein 70 antibody and anti-canine heat shock protein 70 antibody in sera from Babesia gibsoni-infected dogs
Masahiro Yamasaki; Mikiko Ishida; Kensuke Nakamura; Noboru Sasaki; Masahiro Murakami; Wickramasekara Rajapakshage Bandula Kumara; Yu Tamura; Sue Yee Lim; Hiroshi Ohta; Mitsuyoshi Takiguchi
VETERINARY PARASITOLOGY, 180, 3-4, 215, 225, Aug. 2011, [Peer-reviewed]
English, Scientific journal - Expression and subcellular localization of apical junction proteins in canine duodenal and colonic mucosa
Hiroshi Ohta; Tomoki Yamaguchi; B. K. Wickramasekara Rajapakshage; Masahiro Murakami; Noboru Sasaki; Kensuke Nakamura; Shiang-Jyi Hwang; Masahiro Yamasaki; Mitsuyoshi Takiguchi
AMERICAN JOURNAL OF VETERINARY RESEARCH, 72, 8, 1046, 1051, Aug. 2011, [Peer-reviewed]
English, Scientific journal - Babesia gibsoni: Detection in blood smears and formalin-fixed, paraffin-embedded tissues using deoxyribonucleic acid in situ hybridization analysis
Masahiro Yamasaki; Yusuke Kobayashi; Kensuke Nakamura; Noboru Sasaki; Masahiro Murakami; Bandula Kumara Wickramasekara Rajapakshage; Hiroshi Ohta; Osamu Yamato; Yoshimitsu Maede; Mitsuyoshi Takiguchi
EXPERIMENTAL PARASITOLOGY, 127, 1, 119, 126, Jan. 2011
English, Scientific journal - Altered expression of miR-146a correlates with the development of chronic renal inflammation.
Ichii O; Yabuki A; Sasaki N; Otsuka S; Ohta H; Yamasaki M; Takiguchi M; Namiki Y; Hashimoto Y; Endoh D; Kon Y
Kidney Int., 81, 3, 280, 292, 2011, [Peer-reviewed]
English, Scientific journal - Reduced transcript levels of the heat shock protein 70 gene in diminazene aceturate-resistant Babesia gibsoni variants under low concentrations of diminazene aceturate
Shiang-Jyi Hwang; Masahiro Yamasaki; Kensuke Nakamura; Noboru Sasaki; Masahiro Murakami; Bandula Kumara Wickramasekara Rajapakshage; Hiroshi Ohta; Yoshimitsu Maede; Mitsuyoshi Takiguchi
JAPANESE JOURNAL OF VETERINARY RESEARCH, 58, 3-4, 155, 164, Nov. 2010
English, Scientific journal - Reduced transcript levels of the heat shock protein 70 gene in diminazene aceturate-resistant Babesia gibsoni variants under low concentrations of diminazene aceturate
Shiang-Jyi Hwang; Masahiro Yamasaki; Kensuke Nakamura; Noboru Sasaki; Masahiro Murakami; Bandula Kumara Wickramasekara Rajapakshage; Hiroshi Ohta; Yoshimitsu Maede; Mitsuyoshi Takiguchi
JAPANESE JOURNAL OF VETERINARY RESEARCH, 58, 3-4, 155, 164, Nov. 2010, [Peer-reviewed]
English, Scientific journal - Contrast-enhanced ultrasonography for characterization of focal splenic lesions in dogs.
Nakamura K; Sasaki N; Murakami M; Bandula Kumara WR; Ohta H; Yamasaki M; Takagi S; Osaki T; Takiguchi M
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 24, 6, 1290, 1297, 6, Nov. 2010, [Peer-reviewed]
Nakamura K, Sasaki N, Murakami M, Bandula Kumara WR, Ohta H, Yamasaki M, Takagi S, Osaki T, Takiguchi M, <i>Journal of veterinary internal medicine / American College of Veterinary Internal Medicine</i>, 2010, vol. 24, no. 6, pp. 1290-1297 - Development and Characterization of a Strain of Babesia gibsoni Resistant to Diminazene Aceturate In Vitro
Shiang-Jyi Hwang; Masahiro Yamasaki; Kensuke Nakamura; Noboru Sasaki; Masahiro Murakami; Bandula Kumara Wickramasekara Rajapakshage; Hiroshi Ohta; Yoshimitsu Maede; Mitsuyoshi Takiguchi
JOURNAL OF VETERINARY MEDICAL SCIENCE, 72, 6, 765, 771, Jun. 2010
English, Scientific journal - Contrast-enhanced ultrasonography for characterization of canine focal liver lesions.
Nakamura K; Takagi S; Sasaki N; Bandula Kumara WR; Murakami M; Ohta H; Yamasaki M; Takiguchi M
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 51, 1, 79, 85, Jan. 2010, [Peer-reviewed] - EFFECTS AND MECHANISMS OF ACTION OF IONOPHOROUS ANTIBIOTICS VALINOMYCIN AND SALINOMYCIN-NA ON BABESIA GIBSONI IN VITRO
Masahiro Yamasaki; Kensuke Nakamura; Norihisa Tamura; Shiang-Jyi Hwang; Muneyoshi Yoshikawa; Noboru Sasaki; Hiroshi Ohta; Osamu Yamato; Yoshimitsu Maede; Mitsuyoshi Takiguchi
JOURNAL OF PARASITOLOGY, 95, 6, 1532, 1538, Dec. 2009
English, Scientific journal - EFFECTS AND MECHANISMS OF ACTION OF IONOPHOROUS ANTIBIOTICS VALINOMYCIN AND SALINOMYCIN-NA ON BABESIA GIBSONI IN VITRO
Masahiro Yamasaki; Kensuke Nakamura; Norihisa Tamura; Shiang-Jyi Hwang; Muneyoshi Yoshikawa; Noboru Sasaki; Hiroshi Ohta; Osamu Yamato; Yoshimitsu Maede; Mitsuyoshi Takiguchi
JOURNAL OF PARASITOLOGY, 95, 6, 1532, 1538, Dec. 2009, [Peer-reviewed]
English, Scientific journal - Primary splenic torsion in a Boston terrier.
OHTA H; TAKAGI S; MURAKAMI M; SASAKI N; YOSHIKAWA M; NAKAMURA K; HWANG SJ; YAMASAKI M; TAKIGUCHI M
The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 71, 11, 1533, 1535, Nov. 2009, [Peer-reviewed] - Isolation of Antibabesial Compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis
Kazuaki Yamada; Subeki; Kensuke Nabeta; Masahiro Yamasaki; Ken Katakura; Hideyuki Matsuura
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73, 3, 776, 780, Mar. 2009
English, Scientific journal - QUANTITATIVE CONTRAST-ENHANCED ULTRASONOGRAPHY OF CANINE SPLEEN
Kensuke Nakamura; Noboru Sasaki; Muneyoshi Yoshikawa; Hiroshi Ohta; Shiang-Jyi Hwang; Takahiro Mimura; Masahiro Yamasaki; Mitsuyoshi Takiguchi
VETERINARY RADIOLOGY & ULTRASOUND, 50, 1, 104, 108, Jan. 2009
English, Scientific journal - Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis
Ryo Nakao; Chiaki Mizukami; Yuta Kawamura; Subeki; Saw Bawm; Masahiro Yamasaki; Yoshimitsu Maede; Hideyuki Matsuura; Kensuke Nabeta; Nariaki Nonaka; Yuzaburo Oku; Ken Katakura
Journal of Veterinary Medical Science, 71, 1, 33, 41, Jan. 2009
English, Scientific journal - In vitro evaluation of the growth inhibitory activities of 15 drugs against Babesia gibsoni (Aomori strain)
Aya Matsuu; Masahiro Yamasaki; Xuenan Xuan; Hiromi Ikadai; Yoshiaki Hikasa
VETERINARY PARASITOLOGY, 157, 1-2, 1, 8, Oct. 2008
English, Scientific journal - Retrospective diagnosis of feline GM2 gangliosidosis variant 0 (Sandhoff-Like disease) in Japan: Possible spread of the mutant allele in the Japanese domestic cat population
Osamu Yamato; Daisuke Hayashi; Hiroyuki Satoh; Toru Shoda; Keiko Uchida; Hiroyuki Nakayama; Hiroki Sakai; Toshiaki Masegi; Atsuko Murai; Tsuneyoshi IIda; Hiromi Hisada; Atsunori Hisada; Masahiro Yamasaki; Yoshimitsu Maede; Toshiro Arai
JOURNAL OF VETERINARY MEDICAL SCIENCE, 70, 8, 813, 818, Aug. 2008
English, Scientific journal - Heat shock response of Babesia gibsoni heat shock protein 70
Masahiro Yamasaki; Motoshi Tajima; Osamu Yamato; Shiang-Jyl Hwang; Hiroshi Ohta; Yoshimitsu Maede
JOURNAL OF PARASITOLOGY, 94, 1, 119, 124, Feb. 2008
English, Scientific journal - Flow cytometry to evaluate the level of Babesia gibsoni parasitemia in vivo and in vitro by using the fluorescent nucleic acid stain SYTO16
Masahiro Yamasaki; Shiang-Jyi Hwang; Hiroshi Ohta; Osamu Yamato; Yoshimitsu Maede; Mitsuyoshi Takiguchi
JAPANESE JOURNAL OF VETERINARY RESEARCH, 55, 4, 129, 136, Feb. 2008
English, Scientific journal - Molecular screening of canine GM1 gangliosidosis using blood smear specimens after prolonged storage: detection of carriers among Shiba dogs in northern Japan
Osamu Yamato; Eun-Og Jo; Hye-Sook Chang; Hiroyuki Satoh; Toru Shoda; Reeko Sato; Masami Uechi; Naomi Kawasaki; Yoshihisa Naito; Masahiro Yamasaki; Yoshimitsu Maede; Toshiro Arai
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 20, 1, 68, 71A, Jan. 2008
English, Scientific journal - Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica
Subeki; Hideyuki Matsuura; Kosaku Takahashi; Kensuke Nabeta; Masahiro Yamasaki; Yoshimitsu Maede; Ken Katakura
JOURNAL OF NATURAL PRODUCTS, 70, 10, 1654, 1657, Oct. 2007
English, Scientific journal - Suppressive effect of culture supernatant of erythrocytes and serum from dogs infected with Babesia gibsoni on the morphological maturation of canine reticulocytes in vitro
Mohammad Alamgir Hossain; Osamu Yamato; Gonhyung Kim; Masahiro Yamasaki; Yoshimitsu Maede
JOURNAL OF VETERINARY SCIENCE, 8, 2, 169, 174, Jun. 2007
English, Scientific journal - Clinical and molecular analysis of GM2 gangliosidosis in two apparent littermate kittens of the Japanese domestic cat
Daisuke Hasegawa; Osamu Yamato; Masanori Kobayashi; Michio Fujita; Shinichiro Nakamura; Kimimasa Takahashi; Hiroyuki Satoh; Toru Shoda; Daisuke Hayashi; Masahiro Yamasaki; Yoshimitsu Maede; Toshiro Arai; Hiromitsu Orima
JOURNAL OF FELINE MEDICINE AND SURGERY, 9, 3, 232, 237, Jun. 2007
English, Scientific journal - Clinico-pathological findings in peripartum dairy cows fed anion salts lowering the dietary cation-anion difference: Involvement of serum inorganic phosphorus, chloride and plasma estrogen concentrations in milk fever
Naotoshi Kurosaki; Osamu Yamato; Yoshihiko Sasamoto; Fuminobu Mori; Seiichi Imoto; Toshiyuki Kojima; Masahiro Yamasaki; Yoshimitsu Maede
JAPANESE JOURNAL OF VETERINARY RESEARCH, 55, 1, 3, 12, May 2007
English, Scientific journal - Comparison and phylogenetic analysis of the heat shock protein 70 gene of Babesia parasites from dogs
Masahiro Yamasaki; Hisashi Inokuma; Chihiro Sugimoto; Susan E. Shaw; Munir Aktas; Michael J. Yabsley; Osamu Yamato; Yoshimitsu Maede
VETERINARY PARASITOLOGY, 145, 3-4, 217, 227, Apr. 2007
English, Scientific journal - Cerebrospinal fluid biomarkers showing neurodegeneration in dogs with GM1 gangliosidosis: Possible use for assessment of a therapeutic regimen
Hiroyuki Satoh; Osamu Yamato; Tomoya Asano; Madoka Yonemura; Toyofumi Yamauchi; Daisuke Hasegawa; Hiromitsu Orima; Toshiro Arai; Masahiro Yamasaki; Yoshimitsu Maede
BRAIN RESEARCH, 1133, 1, 200, 208, Feb. 2007
English, Scientific journal - Anti-babesial compounds from Rosa damascena mill.
Ahmed Elkhateeb; Hideyuki Matsuura; Masahiro Yamasaki; Yoshimitsu Maede; Ken Katakura; Kensuke Nabeta
NATURAL PRODUCT COMMUNICATIONS, 2, 7, 765, 769, 2007
English, Scientific journal - Anti-babesial compounds from Berberis vulgaris
A. Elkhateeb; K. Yamada; K. Takahashi; H. Matsuura; M. Yamasaki; Y. Maede; K. Katakura; K. Nabeta
NATURAL PRODUCT COMMUNICATIONS, 2, 2, 173, 176, 2007
English, Scientific journal - Anti-babesial compounds from Curcuma xanthorrhiza
Hideyuki Matsuura; Shinkichi Nomura; Subeki; Kazuaki Yamada; Masahiro Yamasaki; Osamu Yamato; Yoshimitsu Maede; Ken Katakura; Trimurningsih; Chairul; Teruhiko Yoshihara; Kensuke Nabeta
NATURAL PRODUCT RESEARCH, 21, 4, 328, 333, 2007, [Peer-reviewed]
English, Scientific journal - Use of amnion and placenta in neonatal screening for canine GM1-gangliosidosis and the risk of diagnostic misclassifications
Osamu Yamato; Eun-Og Jo; Hiroyuki Satoh; Toyofumi Yamauchi; Asogi Kobayashi; Masahiro Yamasaki; Yoshimitsu Maede
Veterinary Clinical Pathology, 35, 1, 91, 94, Mar. 2006, [Peer-reviewed]
English, Scientific journal - Inhibition of Na,K-ATPase activity reduces Babesia gibsoni infection of canine erythrocytes with inherited high K, low Na concentrations
M Yamasaki; A Takada; O Yamato; Y Maede
JOURNAL OF PARASITOLOGY, 91, 6, 1287, 1292, Dec. 2005
English, Scientific journal - Anti-babesial ellagic acid rhamnosides from the bark of Elaeocarpus parvifolius
A. Elkhateeb; Subeki; K. Takahashi; H. Matsuura; M. Yamasaki; O. Yamato; Y. Maede; K. Katakura; T. Yoshihara; K. Nabeta
Phytochemistry, 66, 21, 2577, 2580, Nov. 2005, [Peer-reviewed], [International Magazine]
English, Scientific journal - Evaluation of the Inhibitory Activities of the Extracts of Indonesian Traditional Medicinal Plants against Plasmodium falciparum and Babesia gibsoni
Tri MURNIGSIH; Subeki; Hideyuki MATSUURA; Kosaku TAKAHASHI; Masahiro YAMASAKI; Osamu YAMATO; Yoshimitsu MAEDE; Ken KATAKURA; Mamoru SUZUKI; Sumiko KOBAYASHI; Chairul; Teruhiko YOSHIHARA
Journal of Veterinary Medical Science, 67, 8, 829, 831, Japanese Society of Veterinary Science, Aug. 2005, [Peer-reviewed], [International Magazine]
English, Scientific journal, Twenty-four kinds of water extracts derived from 22 plants that are traditionally used for the treatment of malaria on Java Island, Indonesia, were screened for their antibabesial and antimalarial activities. Among the extracts, 8 extracts displayed strong antimalarial activity, with an inhibition range from 89.6 to 100%, and 15 showed strong antibabesial activity, with an inhibition range from 84.2 to 98.1%. The extracts of Achillea millefolium, Baeckea frutenscens, Brucea javanica, Curcuma xanthorrhiza, Strychnos lucida and Swietenia macrophylla showed both strong antibabesial and antimalarial activities. The antimalarial activities paralleled the antibabesial activities, but the converse was not true. - Identification of heat shock protein 70 in canine reticulocytes and mature erythrocytes
Ja-Ryong Jeong; Masahiro Yamasaki; Tomohiko Komatsu; Mutsumi Inaba; Osamu Yamato; Yoshimitsu Maede
Japanese Journal of Veterinary Research, 53, 1-2, 37, 46, Aug. 2005, [Peer-reviewed]
English, Scientific journal - Growth inhibitory effect of alk(en)yl thiosulfates derived from onion and garlic in human immortalized and tumor cell lines
HS Chang; O Yamato; M Yamasaki; M Ko; Y Maede
CANCER LETTERS, 223, 1, 47, 55, Jun. 2005
English, Scientific journal - Anti-Babesial Compounds fromCurcuma zedoaria
Ken Kasahara; Shinkichi Nomura; Subeki; Hideyuki Matsuura; Masahiro Yamasaki; Osamu Yamato; Yoshimitsu Maede; Ken Katakura; Mamoru Suzuki; Trimurningsih; Chairul; Teruhiko Yoshihara
Planta Medica, 71, 5, 482, 484, Georg Thieme Verlag KG, May 2005, [Peer-reviewed], [International Magazine]
English, Scientific journal, Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 microg/mL, while those of zedoalactones A, B, and C were 16.5, 1.6 and 4.2 microg/mL, respectively. - Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri.
Subeki S; Matsuura H; Takahashi K; Yamasaki M; Yamato O; Maede Y; Katakura K; Kobayashi S; Trimurningsih T; Chairul C; Yoshihara T
Journal of natural products, 68, 4, 537, 539, 4, Apr. 2005, [Peer-reviewed] - Antibabesial Activity of Protoberberine Alkaloids and 20-Hydroxyecdysone from Arcangelisia flava against Babesia gibsoni in Culture
SUBEKI; Hideyuki MATSUURA; Kosaku TAKAHASHI; Masahiro YAMASAKI; Osamu YAMATO; Yoshimitsu MAEDE; Ken KATAKURA; Mamoru SUZUKI; TRIMURNINGSIH; CHAIRUL; Teruhiko YOSHIHARA
Journal of Veterinary Medical Science, 67, 2, 223, 227, Japanese Society of Veterinary Science, Feb. 2005, [Peer-reviewed], [International Magazine]
English, Scientific journal, Bioassay-guided fractionation of the boiled extract from the stems of Arcangelisia flava led to the isolation of palmatine (1), berberine (2), jatrorrhizine (3), dihydroberberine (4) and 20-hydroxyecdysone (5). The chemical structures of these compounds were elucidated on the basis of their chemical and spectral evidence. The isolated compounds were evaluated for their growth inhibiting effects on Babesia gibsoni in culture for a week. Compounds (1-4) showed significant inhibitions at concentrations from 100 to 1.0 microg/ml, while compound 5 at a concentration of 100 microg/ml, only. - Kasahara K, Nomura S, Subeki, Matsuura H, Yamasaki M, Yamato O, Maede Y, Katakura K, Suzuki M, Trimurningsih, Chairul and Yoshihara T; Anti-babesial compounds from Curcuma zedoaria. Planta Med. 71: 482-484, 2005*
2005 - Murnigsih T, Subeki, Matsuura H, Takahashi K, Yamasaki M, Yamato O, Maede Y, Katakura K, Suzuki M, Kobayashi S, Chairul and Yoshihara T; Evaluation of the inhibitory activities of the extracts of Indonesian traditional medical plants against Plasmodium・・・
2005
Murnigsih T, Subeki, Matsuura H, Takahashi K, Yamasaki M, Yamato O, Maede Y, Katakura K, Suzuki M, Kobayashi S, Chairul and Yoshihara T; Evaluation of the inhibitory activities of the extracts of Indonesian traditional medical plants against Plasmodium falciparum and Babesia gibsoni. J. Vet. Med. Sci. 67: 829-831, 2005* - Jeong JR, Yamasaki M, Komatsu T, Inaba M, Yamato O and Maede Y. Identification of heat shock protein 70 in canine reticulocytes and mature erythrocytes. Jpn. J. Vet. Res. 53: 37-46, 2005.*
2005 - Subeki S, Matsuura H, Takahashi K, Yamasaki M, Yamato O, Maede Y, Katakura K, Kobayashi S, Trimurningsih T, Chairul C and Yoshihara T; Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri. J. Nat. Prod. 68: 537-539, 2005.*
2005 - Anti-Babesial Activity of Some Central Kalimantan Plant Extracts and Active Oligostilbenoids fromShorea balangeran
Subeki; Shinkichi Nomura; Hideyuki Matsuura; Masahiro Yamasaki; Osamu Yamato; Yoshimitsu Maede; Ken Katakura; Mamoru Suzuki; Trimurningsih; Chairul; Teruhiko Yoshihara
Planta Medica, 71, 5, 420, 423, Georg Thieme Verlag KG, 2005
Scientific journal, Subeki, Nomura S, Matsuura H, Yamasaki M, Yamato O, Maede Y, Katakura K, Suzuki M, Trimurningsih, Chairul and Yoshihara T; Anti-babesial activity of some central Kalimantan plant extracts and active oligostilbenoids from Shorea balangeran. Planta Med. 71: 420-423, 2005* - Modulatory influence of sodium 2-propenyl thiosulfate from garlic on cyclooxygenase activity in canine platelets: Possible mechanism for the anti-aggregatory effect
H.S. Chang; O. Yamato; M. Yamasaki; Y. Maede
Prostaglandins, Leukotrienes and Essential Fatty Acids, 72, 5, 351, 355, Elsevier BV, 2005
Scientific journal, Chang HS, Yamato O, Yamasaki M and Maede Y. Modulatory influence of sodium 2-propenyl thiosulfate from garlic on cyclooxygenase activity in canine pletelets: Possible mechanism for the anti-aggregatory effect. Prostaglandins, Leukotrienes and Essential Fatty Acids (Prostaglandins Leukot. Essent. Fatty Acids) 72: 351-355, 2005.* - Subeki, Matsuura H, Takahashi K, Yamasaki M, Yamato O, Maede Y, Katakura K, Suzuki M, Trimurningsih, Chairul and Yoshihara T; Antibabesial activity of protoberberine alkaloids and 20-hydroxyecdysone from Arcangelisia flava against Babesia gibsoni in cu・・・
2005
Subeki, Matsuura H, Takahashi K, Yamasaki M, Yamato O, Maede Y, Katakura K, Suzuki M, Trimurningsih, Chairul and Yoshihara T; Antibabesial activity of protoberberine alkaloids and 20-hydroxyecdysone from Arcangelisia flava against Babesia gibsoni in culture. J. Vet. Med. Sci. 67: 223-227, 2005* - Heinz body hemolytic anemia with eccentrocytosis due to ingestion of Chinese chive (Allium tuberosum) and garlic (A. sativum) in a dog.
Yamato, O; Kasai, E; Katsura, T; Takahashi, S; Shiota, T; Tajima, M; Yamasaki, M; Maede, Y
Journal of American Animal Hospital Association, 41, 68, 73, 2005, [Peer-reviewed]
English, Scientific journal - Rapid and simple mutation screening of G(M1) gangliosidosis in Shiba dogs by direct amplification of deoxyribonucleic acid from various forms of canine whole-blood specimens
O Yamato; EO Jo; T Shoda; M Yamasaki; Y Maede
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 16, 5, 469, 472, Sep. 2004
English, Scientific journal - Long-term Clinical Remission in Response to Glucocorticoid Therapy in a Chihuahua with Granulomatous Meningoencephalitis
KONTANI Yuko; YAMATO Osamu; OCHIAI Kenji; YAMASAKI Masahiro; MAEDE Yoshimitsu
Journal of the Japan Veterinary Medical Association, 57, 7, 446, 450, 日本獸医師会, 20 Jul. 2004
肉芽腫性髄膜脳炎を発症した4歳齢、雌のチワワに対し、糖質コルチコイドによる治療を行い、長期の寛解状態を維持することができた。発病時の運動失調、四肢麻痺、右半身の強直、左側への斜頸および眼振などの神経症状は、デキサメサゾンによる2週間の治療により改善した。その後、プレドニゾロン0.2-0.5mg/kgを2日に1回経口投与することにより、2年半の間、寛解状態を維持することができた。しかし、治療開始後2年8-9ヵ月目には、重度の運動障害、痙攣および情動異常が認められたため、予後不良と判断し安楽死後病理検査を実施した。肉眼所見では左小脳半球の髄膜肥厚を伴う矮小化が認められ、組織学的に本症例は播種性の肉芽腫性髄膜脳炎と診断された。 - Inhibitory effect of pyrimidine and purine nucleotides on the multiplication of Babesia gibsoni: Possible cause of low parasitemia and simultaneous reticulocytosis in canine babesiosis
MA Hossain; O Yamato; M Yamasaki; Y Maede
JOURNAL OF VETERINARY MEDICAL SCIENCE, 66, 4, 389, 395, Apr. 2004
English, Scientific journal - Chang, H. S., Yamato, O., Sakai, Y., Yamasaki, M. and Maede, Y.:"Acceleration of superoxide generation in polymorphonuclear leukocytes and inhibition of platelet aggregation by alk(en)yl thiosulfates derived from onion and garlic in dogs and humans",Pr・・・
2004
Chang, H. S., Yamato, O., Sakai, Y., Yamasaki, M. and Maede, Y.:"Acceleration of superoxide generation in polymorphonuclear leukocytes and inhibition of platelet aggregation by alk(en)yl thiosulfates derived from onion and garlic in dogs and humans",Prostaglandins Leukot. Essent. Fatty Acids 70 : 77-83(2004)* - Yamato, O., Satoh, H., Matsuki, N., Ono, K., Yamasaki, M. and Maede,Y:"Laboratory diagnosis of canine GM2-gangliosidosis using blood and cerebrospinal fluid",J. Vet. Diagn. Invest. 16 : 39-44(2004)*
2004 - Yamato, O., Matsunaga, S., Takata, K., Uetsuka, K., Satoh, H., Shoda, T., Baba, Y., Yasoshima, A., Kato, K., Takahashi, K., Yamasaki, M., Nakayama, H., Doi, K., Maede, Y. and Ogawa, H.:"GM2-gangliosidosis variant 0 (Sandhoff-like disease) in a family o・・・
2004
Yamato, O., Matsunaga, S., Takata, K., Uetsuka, K., Satoh, H., Shoda, T., Baba, Y., Yasoshima, A., Kato, K., Takahashi, K., Yamasaki, M., Nakayama, H., Doi, K., Maede, Y. and Ogawa, H.:"GM2-gangliosidosis variant 0 (Sandhoff-like disease) in a family of Japanese domestic cats",Vet. Rec. 155 : 739-744(2004)* - Subeki, Matsuura, H., Yamasaki, M., Yamato, O., Maede, Y., Katakura, K., Suzuki, M., Trimurningsih, Chairul and Yoshihara, T.:"Effects of central Kalimantan plant extracts on intraerythrocytic Babesia gibsoni in culture",J. Vet. Med. Sci. 66 : 871-874(・・・
2004
Subeki, Matsuura, H., Yamasaki, M., Yamato, O., Maede, Y., Katakura, K., Suzuki, M., Trimurningsih, Chairul and Yoshihara, T.:"Effects of central Kalimantan plant extracts on intraerythrocytic Babesia gibsoni in culture",J. Vet. Med. Sci. 66 : 871-874(2004)* - Yamato, O., Kobayashi, A., Satoh, H., Endoh, D., Shoda, T., Masuoka, Y., Hatakeyama, A., Jo, E. O., Asano, T., Yonemura, M., Yamasaki, M. and Maede, Y.:"Comparison of polymerase chain reaction-restriction fragment length polymorphism assay and enzyme a・・・
2004
Yamato, O., Kobayashi, A., Satoh, H., Endoh, D., Shoda, T., Masuoka, Y., Hatakeyama, A., Jo, E. O., Asano, T., Yonemura, M., Yamasaki, M. and Maede, Y.:"Comparison of polymerase chain reaction-restriction fragment length polymorphism assay and enzyme assay for diagnosis of GM1-gangliosidosis in Shiba dogs",J. Vet. Diagn. Invest. 16 : 299-304(2004)* - Kontani, Y., Yamato, O., Ochiai, K., Yamasaki, M. and Maede, Y.:"A long-term clinical remission in response to corticosteroid therapy in a Chihuahua dog with granulomatous meningoencephalitis",J. Jpn. Vet. Med. Assoc. 57 : 446-450. (in Japanese with En・・・
2004
Kontani, Y., Yamato, O., Ochiai, K., Yamasaki, M. and Maede, Y.:"A long-term clinical remission in response to corticosteroid therapy in a Chihuahua dog with granulomatous meningoencephalitis",J. Jpn. Vet. Med. Assoc. 57 : 446-450. (in Japanese with English summary)(2004)* - Satoh, H., Yamato, O., Asano, T., Yamasaki, M. and Maede, Y.:"Increased concentration of GM1-ganglioside in cerebrospinal fluid in dogs with GM1- and GM2-gangliosidoses and its clinical application for diagnosis",J. Vet. Diagn. Invest. 16 : 223-226(2004)*
2004 - Comparison of polymerase chain reaction-restriction fragment length polymorphism assay and enzyme assay for diagnosis of GM1- gangliosidosis in Shiba dogs
Osamu Yamato; Asogi Kobayashi; Hiroyuki Satoh; Daiji Endoh; Toru Shoda; Yukiko Masuoka; Ayano Hatakeyama; Eun-Og Jo; Tomoya Asano; Madoka Yonemura; Masahiro Yamasaki; Yoshimitsu Maede
Journal of Veterinary Diagnostic Investigation, 16, 4, 299, 304, American Assoc. of Veterinary Laboratory Diagnosticians, 2004, [Peer-reviewed]
English, Scientific journal - Increased concentration of GM1-ganglioside in cerebrospinal fluid in dogs with GM1- and GM2-gangliosidoses and its clinical application for diagnosis
Hiroyuki Satoh; Osamu Yamato; Tomoya Asano; Masahiro Yamasaki; Yoshimitsu Maede
Journal of Veterinary Diagnostic Investigation, 16, 3, 223, 226, American Assoc. of Veterinary Laboratory Diagnosticians, 2004, [Peer-reviewed]
English, Scientific journal - Laboratory diagnosis of canine GM2-gangliosidosis using blood and cerebrospinal fluid
Osamu Yamato; Hiroyuki Satoh; Naoaki Matsuki; Kenichiro Ono; Masahiro Yamasaki; Yoshimitsu Maede
Journal of Veterinary Diagnostic Investigation, 16, 1, 39, 44, American Assoc. of Veterinary Laboratory Diagnosticians, 2004, [Peer-reviewed]
English, Scientific journal - Serum from dogs infected with Babesia gibsoni inhibits maturation of reticulocytes and erythrocyte 5′-nucleotidase activity in vitro
Mohammad Alamgir Hossain; Osamu Yamato; Masahiro Yamasaki; Ja-Ryong Jeong; Hye-Sook Chang; Yoshimitsu Maede
Journal of Veterinary Medical Science, 65, 12, 1281, 1286, Dec. 2003, [Peer-reviewed]
English, Scientific journal - Babesia gibsoni-specific isoenzymes related to energy metabolism of the parasite in infected erythrocytes
Masahiro Yamasaki; Mohammad Alamgir Hossain; Ja-Ryong Jeong; Hye-Sook Chang; Hiroyuki Satoh; Osamu Yamato; Yoshimitsu Maede
Journal of Parasitology, 89, 6, 1142, 1146, Dec. 2003, [Peer-reviewed]
English, Scientific journal - Clinical and clinico-pathologic characteristics of Shiba dogs with a deficiency of lysosomal acid beta-galactosidase: a canine model of human GM1 gangliosidosis.
Yamato O; Masuoka Y; Yonemura M; Hatakeyama A; Satoh H; Kobayashi A; Nakayama M; Asano T; Shoda T; Yamasaki M; Ochiai K; Umemura T; Maede Y
The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 65, 2, 213, 217, 2, Feb. 2003, [Peer-reviewed] - Yamato, O., Satoh, H., Matsuki, N., Ono, K., Yamasaki, M. and Maede, Y.:"Laboratory diagnosis of canine GM2-gangliosidosis using blood and cerebrospinal fluid",J. Vet. Diagn. Invest. 16:39-44(2003)*
2003 - Yamasaki, M., Yamato, O., Hossain, M. A., Jeong, J. R., Chang, H. S., Satoh, H. and Maede, Y.:"Babesia gibsoni: preferantial multiplication in reticulocytes is related to the presence of mitochondria and a high concentration of adenosine 5'-triphosphat・・・
2003
Yamasaki, M., Yamato, O., Hossain, M. A., Jeong, J. R., Chang, H. S., Satoh, H. and Maede, Y.:"Babesia gibsoni: preferantial multiplication in reticulocytes is related to the presence of mitochondria and a high concentration of adenosine 5'-triphosphate in the cells", Exp. Parasitol. 102 : 164-169(2003)* - Yamasaki, M., Tajima, M., Lee, K. W., Joeng, J. R., Yamato, O. and Maede, Y.:"Molecular cloning and phylogenetic analysis of Babesia gibsoni heat shock protein 70",Vet. Parasitol. 110 : 123-129(2003)*
2003 - Hossain,MA., Yamato,O., Yamasaki,M., Otsuka,Y.and Maede,Y. : "Relation between Reticulocyte Count and substrate specificity of Erythrocyte 5'-Nucleotidase in Dogs, Cats, Cattle and Humans",J. Vet. Med. Sci. 65(2):193-197(2003)*
2003 - Yamasaki,M.,Hossain,M.A.,Jeong,J.R.,Chang,H.S.,Satoh,H.,Yamato,O.and Maede,Y.:" Babesia gibsoni-specific isozymes related to energy metabolism of the parasite in the infected erythrocytes"J.Parasitol.89,1142-1146(2003)*
2003 - Hossain,M.A.,Yamato,O.,Yamasaki,M.,Joeng,J.R.,Chang,H.S.and Maede,Y.:"Serum from dogs infected with Babesia gibsoni inhibits maturation of reticulocytes and erythrocyte 5`-nucleotidase activity in vitro"J.Vet.Med.Sci.65,1281-1286(2003)*
2003 - Yamato,O.,Masuoka,Y.,Yonemura,M.,Hatakeyama,A.,Kobayashi,A.,Satoh,H.,Nakayama,M., Asano,T.,Shoda,T.,Yamasaki,M.,Ochiai,K.,Umemura,T.and Maede,Y.:"Clinical and clinico-pathologic characteristics of Shiba dogs with a deficiency of lysosomal acid β-galact・・・
2003
Yamato,O.,Masuoka,Y.,Yonemura,M.,Hatakeyama,A.,Kobayashi,A.,Satoh,H.,Nakayama,M., Asano,T.,Shoda,T.,Yamasaki,M.,Ochiai,K.,Umemura,T.and Maede,Y.:"Clinical and clinico-pathologic characteristics of Shiba dogs with a deficiency of lysosomal acid β-galactosidase: A canine model of human GM1 gangliosidosis", J. Vet. Med. Sci. 65, 213-217(2003)* - Hossain,M.A.,Yamato,O.,Yamasaki,M.and Maede,Y.:"Clinical and haematobiochemical studies on experimentally induced chronic babesiosis in splenectomized adult dogs",Bangl.J.Vet.Med.1,53-56(2003)*
2003 - Clinical and Haematobiochemical Studies on Experimentally Induced Chronic Babesiosis in Splenectomized Adult Dogs
MA Hossain; O Yamato; M Yamasaki; Y Maede
Bangladesh Journal of Veterinary Medicine, 1, 1, 53, 56, Bangladesh Journals Online (JOL), Jan. 2003, [Peer-reviewed]
English, Scientific journal, The pathogenicity of the carrier Babesia gibsoni organism was studied in the experimentally inoculated carrier blood into the three susceptible splenectomized adult dogs during the period between 2000 to 2002. The pathogenic effect was assessed on clinical pictures and haematobiochemical changes. All the three experimentally infected dogs showed signs of depression, anorexia and anaemia (pale visible mucous membrane) at 2 years of post-infection. Haematological effects included macrocytic normochromic anemia with polychromasia, anisocytosis and a marked increased in nucleated erythrocytes. Biochemical changes included significant (p < 0.05) increase in mean total serum protein (8.27 ± 2.37), serum bilirubin (1.02 ± 0.11), total serum iron (279 ± 142.03) in comparison to control healthy dogs. It may be concluded from this study that the chronic canine babesiosis caused by B. gibsoni is highly pathogenic associated with anaemia and haematobiochemical alteration. Key words: Haematobiochemical changes chronic babesiosis, experimentally induced, splenectomized dog DOI = 10.3329/bjvm.v1i1.1919 Bangl. J. Vet. Med. (2003). 1(1) : 53 - 56 - Relation between reticulocyte count and characteristics of erythrocyte 5′-nucleotidase in dogs, cats, cattle and humans
Mohammad Alamgir Hossain; Osamu Yamato; Masahiro Yamasaki; Yayoi Otsuka; Yoshimitsu Maede
Journal of Veterinary Medical Science, 65, 2, 193, 197, Maruzen Co. Ltd., 2003, [Peer-reviewed]
English, Scientific journal - Babesia gibsoni: Preferential multiplication in reticulocytes is related to the presence of mitochondria and a high concentration of adenosine 5′-triphosphate in the cells
Masahiro Yamasaki; Osamu Yamato; Mohammad Alamgir Hossain; Ja-Ryong Jeong; Hye-Sook Chang; Hiroyuki Satoh; Yoshimitsu Maede
Experimental Parasitology, 102, 3-4, 164, 169, Academic Press Inc., 01 Nov. 2002, [Peer-reviewed]
English, Scientific journal - Sandhoff disease in a golden retriever dog
O. Yamato; N. Matsuki; H. Satoh; M. Inaba; K. Ono; M. Yamasaki; Y. Maede
Journal of Inherited Metabolic Disease, 25, 4, 319, 320, Wiley, Jun. 2002, [Peer-reviewed], [International Magazine]
English, Scientific journal, A golden retriever dog is described with total hexosaminidase deficiency and raised GM2-ganglioside in CSF. The animal represents a model for human Sandhoff disease. - Isolation and Identification of Organosulfur Compounds Oxidizing Canine Erythrocytes from Garlic (Allium Sativum)
Qiuhui Hu; Qing Yang; Osamu Yamato; Masahiro Yamasaki; Yoshimitsu Maede; Teruhiko Yoshihara
Journal of Agricultural and Food Chemistry, 50, 5, 1059, 1062, American Chemical Society (ACS), 01 Feb. 2002, [Peer-reviewed], [International Magazine]
English, Scientific journal, Five compounds oxidizing canine erythrocytes were isolated from an aqueous ethanol garlic extract by silica gel column chromatography and preparative thin-layer chromatography. On the basis of nuclear magnetic resonance, infrared spectroscopy, and mass spectrometry, they were identified as three known compounds: bis-2-propenyl trisulfide (1), bis-2-propenyl tetrasulfide (2), and bis-2-propenyl pentasulfide (3) as well as two novel compounds, bis-2-propenyl thiosulfonate (4) and trans-sulfuric acid allyl ester 3-allylsulfanyl-allyl ester (5). A mixture of compounds 1-3 and compounds 4 and 5 induced methemoglobin formation in canine erythrocyte suspension in vitro resulting in the oxidation of canine erythrocytes. These groups of characteristic organosulfur compounds contained in garlic probably contribute to oxidations in blood. The constituents of garlic have the potential to oxidize erythrocytes and hemoglobin, suggesting that foods containing quantities of garlic should be avoided for feeding dogs. - Hu, Q., Yang, Q., Yamato, O., Yamasaki, M., Maede, Y. and Yoshihara, T.:"Isolation and identification of organosulfur compounds oxidizing canine erythrocytes from garlic (Allium sativum)", J. Agri. Food Chem., 50:1059-1062(2002)*
2002 - Zhou, J., Mulenga, A., Yamasaki, M., Ohashi, K., Maede, Y. and Onuma, M.:"Babesia gibsoni: molecular cloning and characterization of Rab6 and Rab11 homologues", Exp. Parasitol., 101:210-214(2002)*
2002 - Yamato, O., Endoh, D., Kobayashi, A., Masuoka, Y., Hatakeyama, A., Yonemura, M., Satoh, H., Tajima, M., Yamasaki, M. and Maede, Y.:"A novel mutation in the gene of canine acid b-galactosidase that causes GM1-gangliosidosis in Shiba dogs", J. Inherit. ・・・
2002
Yamato, O., Endoh, D., Kobayashi, A., Masuoka, Y., Hatakeyama, A., Yonemura, M., Satoh, H., Tajima, M., Yamasaki, M. and Maede, Y.:"A novel mutation in the gene of canine acid b-galactosidase that causes GM1-gangliosidosis in Shiba dogs", J. Inherit. Metab. Dis., 25:525-526 (2002)* - The Effect of Macrophages on the Erythrocyte Oxidative Damage and the Pathogenesis of Anemia in Babesia gibsoni-Infected Dogs with Low Parasitemia.
Yayoi OTSUKA; Masahiro YAMASAKI; Osamu YAMATO; Yoshimitsu MAEDE
Journal of Veterinary Medical Science, 64, 3, 221, 226, Japanese Society of Veterinary Science, 2002
Scientific journal - Yamato, O., Matsuki, N., Satoh, H., Inaba, M., Ono, K., Yamasaki, M. and Maede, Y.:"Sandhoff disease in a golden retriever dog", J. Inherit. Metab. Dis., 25:319-320(2002)*
2002 - Molecular cloning and phylogenetic analysis of Babesia gibsoni heat shock protein 70
Yamasaki,M; Tajima,M.,Lee; K.W; Joeng,J.R; Yamato,O; Maede,Y
Veterynary Parasitology, 110, 123, 129, 2002, [Peer-reviewed]
English, Scientific journal - A novel mutation in the gene for canine acid β-galactosidase that causes GM1-gangliosidosis in Shiba dogs
Yamato,O; Endoh,D; Kobayashi ,A; Masuoka,Y; Yonemura ,M; Hatakeyama ,A; Satoh.H; Tajima,M; Yamasaki ,M; Maede,Y
J. Inherit. Metab. Dis., 25, 6, 525, 526, 2002, [Peer-reviewed]
English, Scientific journal, Yamato,O.,Endoh,D.,Kobayashi ,A.,Masuoka,Y.,Yonemura ,M.,Hatakeyama ,A.,Satoh.H.,Tajima,M., Yamasaki ,M. and Maede,Y. : "A novel mutation in the gene for canine acid β-galactosidase that causes GM1-gangliosidosis in Shiba dogs", Journal of Inherited Metabolic Disease 25: 525-526(2002)* - Increased Generation of Superoxide in Erythrocytes infected with Babesia gibsoni
Yayoi Otsuka; Masahiro Yamasaki; Osamu Yamato; Yoshimitsu Maede
Journal of Veterinary Medical Science, 63, 10, 1077, 1081, Oct. 2001, [Peer-reviewed]
English, Scientific journal - Otsuka,Y.,Yamasaki,M.,Yamato,O.and Maede,Y.:"Increased generation of superoxide in erythrocytes infected with Babesia gibsoni", J.Vet.Med.Sci.,63:1077-1081(2001)*
2001 - Use of canine red blood cell with high concentrations of potassium, reduced glutathione, and free amino acid as host cells for in vitro cultivation of Babesia gibsoni
M Yamasaki; H Asano; Y Otsuka; O Yamato; M Tajima; Y Maede
AMERICAN JOURNAL OF VETERINARY RESEARCH, 61, 12, 1520, 1524, Dec. 2000
English, Scientific journal - Yamasaki, M., Otsuka, Y., Yamato, O., Tajima, M. and Maede, Y.:" The cause of the predilection of Babesia gibsoni for reticulocytes ", J. Vet. Med. Sci. 62: 737-741 (2000)*
2000 - The cause of the predilection of Babesia gibsoni for reticulocytes
Yamasaki,M; Otsuka,Y; Yamato,O; Tajima,M; Maede,Y
J.Vet.Med.Sci., 62, 7, 737, 741, 2000, [Peer-reviewed]
English, Scientific journal - Reduced glutathione accelerates the oxidative damage produced by sodium n-propylthiosulfate, one of the causative agents of onion-induced hemolytic anemia in dogs
Osamu Yamato; Morihiko Hayashi; Ei Kasai; Motoshi Tajima; Masahiro Yamasaki; Yoshimitsu Maede
Biochimica et Biophysica Acta - General Subjects, 1427, 2, 175, 182, 19 Apr. 1999, [Peer-reviewed]
English, Scientific journal - Yamato, O., Hayashi, M., Kasai, E., Tajima, M., Yamasaki, M. and Maede, Y. :"Reduced glutathione accelerates oxidative damages produced by sodium n-propylthiosulfate, one of the causative agents in onion-induced hemolytic anemia in dogs", Biochim. Biop・・・
1999
Yamato, O., Hayashi, M., Kasai, E., Tajima, M., Yamasaki, M. and Maede, Y. :"Reduced glutathione accelerates oxidative damages produced by sodium n-propylthiosulfate, one of the causative agents in onion-induced hemolytic anemia in dogs", Biochim. Biophys. Acta, 1427(2): 175-182. (1999)* - Induction of onion-induced haemolytic anaemia in dogs with sodium n -propylthiosulphate
O. Yamato; M. Hayashi; M. Yamasaki; Y. Maede
Veterinary Record, 142, 9, 216, 219, Wiley, Feb. 1998, [Peer-reviewed], [International Magazine]
English, Scientific journal, The haemolytic effect of sodium n-propylthiosulphate, which had been isolated from boiled onions, was studied to determine whether it could be one of the agents responsible for induced haemolytic anaemia in dogs. The oral administration of 500 mumol/kg bodyweight of the compound to dogs resulted in a haemolytic anaemia associated with an increase of Heinz body formation in erythrocytes, which was more severe in dogs with the hereditary condition which results in erythrocytes with high concentrations of reduced glutathione and potassium than in normal dogs. In the affected dogs there was a 10-fold increase in the concentration of oxidised glutathione in their erythrocytes 12 hours after the administration of the compound, whereas in normal dogs there was almost no change.
- 犬バベハア症治療における熱ショック蛋白質90の薬剤標的としての可能性
ABE MOEKO; YAMASAKI MASAHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 157th, 361, 11 Aug. 2014
Japanese - 犬の非感染性髄膜脳炎症例の脳脊髄液中におけるサイトカインの発現解析
OTA HIROSHI; KAMADA MAYUMI; MORISHITA KEITARO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医神経病学会, 40th, 19, 05 Jul. 2014
Japanese - 犬胃癌10症例における超音波検査所見
YOKOYAMA NOZOMI; OTA HIROSHI; NAKAMURA KENSUKE; MORISHITA KEITARO; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 45, Suppl.1, 261, 261, Jun. 2014
(一社)日本獣医麻酔外科学会, Japanese - 徐脈性不整脈に対してピモベンダンを投与し失神の改善を認めた犬の1例
MORITA TOMOYA; SUZUKI SHUJI; NAKAMURA KENSUKE; OSUGA TATSUYUKI; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 45, Suppl.1, 248, 248, Jun. 2014
(一社)日本獣医麻酔外科学会, Japanese - 造影超音波検査による腎機能評価の基礎的検討
MORISHITA KEITARO; RIN SU・I; OSUGA TATSUYUKI; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 45, Suppl.1, 262, 262, Jun. 2014
(一社)日本獣医麻酔外科学会, Japanese - 2D Speckle Tracking法を用いた左心房機能評価による犬心筋症の重症度評価
OSUGA TATSUYUKI; NAKAMURA KENSUKE; SUZUKI SHUJI; MORISHITA KEITARO; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医師会雑誌, 67, 5, 367, 20 May 2014
Japanese - プレドニゾロンを主とする免疫抑制療法実施症例における犬膵特異的リパーゼの推移
OTA HIROSHI; MORISHITA KEITARO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医師会雑誌, 67, 5, 369, 20 May 2014
Japanese - セルレイン誘発膵炎犬における造影超音波検査の定量的および定性的評価
LIM SUE YEE; NAKAMURA KENSUKE; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医畜産新報, 1113, 286, 288, 01 Apr. 2014
Japanese - Dual pulsed‐wave doppler法による右室Tei‐index測定の再現性
MORITA TOMOYA; NAKAMURA KENSUKE; OSUGA TATSUYUKI; SUZUKI SHUJI; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 44, Suppl.2, 250, 250, Dec. 2013
(一社)日本獣医麻酔外科学会, Japanese - 猫心筋症において2D Speckle Tracking法を用いた左心房機能評価は可能であるのか
OSUGA TATSUYUKI; NAKAMURA KENSUKE; SUZUKI SHUJI; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 44, Suppl.2, 249, 249, Dec. 2013
(一社)日本獣医麻酔外科学会, Japanese - LC-MS/MS Analysis of Canine Lipoproteins Fractionated Using the Ultracentrifugation-Precipitation Method (vol 75, pg 1471, 2013)
Asuka Suto; Masahiro Yamasaki; Yukari Takasaki; Yasuyuki Fujita; Riichiro Abe; Hiroshi Shimizu; Hiroshi Ohta; Mitsuyoshi Takiguchi, JOURNAL OF VETERINARY MEDICAL SCIENCE, 75, 12, 1678, 1678, Dec. 2013
English, Others - 両側性尿管閉塞を呈した犬の1例
TOOYAMA NOBUO; NAKAMURA KENSUKE; KAGAWA YUMIKO; MORISHITA KEITARO; OTA HIROSHI; TAKAGI SATOSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 34th, 2, 3, 4, 15 Nov. 2013
Japanese - 非典型的溶血性尿毒症症候群(D‐HUS)が疑われた犬の1例
MORISHITA KEITARO; TOOYAMA NOBUO; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 34th, 2, 141, 142, 15 Nov. 2013
Japanese - 慢性特発性偽性腸閉塞症が疑われた犬の1例
YOKOYAMA NOZOMU; OTA HIROSHI; HASHIBA KANO; MORISHITA KEITARO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; OCHIAI KENJI; TERAMOTO HIDESHI; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 34th, 2, 59, 60, 15 Nov. 2013
Japanese - 市販フードの給餌によって病的骨折を起こした栄養性二次性上皮小体機能亢進症の犬の1例
HASHIBA KANO; MORISHITA KEITARO; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 34th, 2, 119, 120, 15 Nov. 2013
Japanese - 組織奇形が疑われた膀胱粘膜下嚢胞の犬の1例
MORISHITA KEITARO; HOSOYA KENJI; OSUGA TATSUYUKI; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 34th, 2, 9, 10, 15 Nov. 2013
Japanese - 超音波検査により診断が可能であった子宮捻転の犬の1例
中村 健介; 山崎 真大; 大田 寛; 森下 啓太郎; 木村 享史; 滝口 満喜, 日本獣医画像診断学会抄録, 54回, 28, 28, Sep. 2013
日本獣医画像診断学会, Japanese - ジミナゼン耐性Babesia gibsoniの熱ショック蛋白質90遺伝子発現量の測定
IDAKA NATSUKI; YAMASAKI MASAHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 156th, 236, 30 Aug. 2013
Japanese - プレドニゾロンを主とする免疫抑制療法実施症例における犬膵特異的リパーゼの推移
OTA HIROSHI; MORISHITA KEITARO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 57, 8, 402, 10 Aug. 2013
Japanese - 輪状咽頭アカラシアの犬の1例
UENO TAKASHI; OTA HIROSHI; TAKAGI SATOSHI; HOSHI KIYOTAKA; MORISHITA KEITARO; NAKAMURA TAKESHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 57, 8, 401, 10 Aug. 2013
Japanese - 2D Speckle Tracking法を用いた左心房機能評価による犬心筋症の重症度評価
OSUGA TATSUYUKI; NAKAMURA KENSUKE; HOSOYA KENJI; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 57, 8, 396, 10 Aug. 2013
Japanese - 非典型的溶血性尿毒症症候群(D‐HUS)が疑われた犬の1例
TOOYAMA NOBUO; MORISHITA KEITARO; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 57, 8, 395, 10 Aug. 2013
Japanese - 閉鎖式持続吸引ドレーンにて良好にコントロールできた膵膿瘍の犬の1例
YAMAGUCHI TOMOO; MORISHITA KEITARO; HOSOYA KENJI; MUKAIDANI RYUSUKE; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 57, 8, 400, 10 Aug. 2013
Japanese - 特発性収縮性心膜炎の犬の1例
OSUGA TATSUYUKI; NAKAMURA KENSUKE; HOSOYA KENJI; MORITA TOMOYA; KAGAWA YUMIKO; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 44, Suppl.1, 245, 245, Jun. 2013
(一社)日本獣医麻酔外科学会, Japanese - 肝静脈血流波形解析による右心不全の重症度評価
NAKAMURA KENSUKE; OSUGA TATSUYUKI; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医師会雑誌, 66, 5, 346, 347, 20 May 2013
Japanese - MARKED INCREASED EXPRESSION OF INTERLEUKIN 8 IN THE COLORECTAL MUCOSA OF DOGS WITH INFLAMMATORY COLORECTAL POLYPS BUT NOT WITH LYMPHOCYTIC-PLASMACYTIC COLITIS
Y. Tamura; H. Ohta; N. Yokoyama; K. Morishita; K. Nakamura; M. Yamasaki; M. Takiguchi, JOURNAL OF VETERINARY INTERNAL MEDICINE, 27, 3, 706, 706, May 2013
English, Summary international conference - ミニチュア・ダックスフンドの炎症性結直腸ポリープの病態
OTA HIROSHI; TAMURA YU; YOKOYAMA NOZOMI; MORISHITA KEITARO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 155th, 153, 04 Mar. 2013
Japanese - Babesia gibsoni熱ショック蛋白質90の遺伝子クローニングおよび系統樹解析
YAMASAKI MASAHIRO; TSUBOI YOSHIHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本寄生虫学会大会プログラム・抄録集, 82nd, 84, Feb. 2013
Japanese - 末梢肺動脈狭窄症と診断した高齢猫の1例
OSUGA TATSUYUKI; NAKAMURA KENSUKE; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 43, Suppl.2, 213, 213, Dec. 2012
(一社)日本獣医麻酔外科学会, Japanese - Diminazene aceturate耐性Babesia gibsoniの核酸取り込み量の測定
WATANABE NATSUO; YAMASAKI MASAHIRO; KUMARA W; R. BANDULA; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 154th, 215, 31 Aug. 2012
Japanese - ミニチュア・ダックスフンドの炎症性結直腸ポリープ病変における炎症性サイトカインの発現解析
田村悠; 大田寛; 村上正紘; BANDULA Kumara WR; SUE Yee Lim; 大菅辰幸; 森下啓太郎; 中村健介; 山崎真大; 滝口満喜, 日本獣医学会学術集会講演要旨集, 154th, 307, 31 Aug. 2012
Japanese - 好酸球増多症候群を伴った消化器型リンパ腫の猫の1例
TOOYAMA NOBUO; HOSOYA KENJI; NAKAMURA KENSUKE; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 56, 8, 399, 10 Aug. 2012
Japanese - 下垂体性副腎皮質機能亢進症とクロム親和性細胞腫を併発した犬の1例
KANAZAWA TOMONORI; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; OTA HIROSHI; TAKAGI SATOSHI; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 56, 8, 410, 10 Aug. 2012
Japanese - 麻酔後の全脳虚血が疑われた2症例のMRI所見
OTA HIROSHI; MORISHITA KEITARO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 56, 8, 429, 10 Aug. 2012
Japanese - 肝静脈血流波形解析による右心不全の重症度評価
NAKAMURA KENSUKE; OSUGA TATSUYUKI; MORISHITA KEITARO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 56, 8, 409, 10 Aug. 2012
Japanese - 両側性子宮分節性無形成から片側性子宮角捻転に至った犬の1例
YOKOYAMA NOZOMI; NAKAMURA KENSUKE; KIMURA TAKASHI; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 56, 8, 418, 10 Aug. 2012
Japanese - 下垂体性副腎皮質機能亢進症と中枢性尿崩症を併発し,放射線治療を行った下垂体腫瘍の犬の1例
田村悠; 山崎真大; 森下啓太郎; 中村健介; 大田寛; 滝口満喜, 北海道獣医師会雑誌, 56, 8, 410, 10 Aug. 2012
Japanese - 房室ブロックの犬2例に認められた低速僧帽弁逆流と高速左室駆出血流
NAKAMURA KENSUKE; TOOYAMA NOBUO; UENO TAKASHI; MORISHITA KEITARO; OSUGA TATSUYUKI; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 43, Suppl.1, 245, 245, Jun. 2012
(一社)日本獣医麻酔外科学会, Japanese - 犬の頭蓋内疾患診断における経頭蓋超音波ドプラ法の有用性の検討
SASAOKA KAZUYOSHI; NAKAMURA KENSUKE; MORISHITA KEITARO; OSUGA TATSUYUKI; LIM SUE YEE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 43, Suppl.1, 270, 270, Jun. 2012
(一社)日本獣医麻酔外科学会, Japanese - CT検査を実施した肝葉捻転の犬の2例
MORISHITA KEITARO; HOSOYA KENJI; TAKAGI SATOSHI; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 43, Suppl.1, 267, 267, Jun. 2012
(一社)日本獣医麻酔外科学会, Japanese - INTERLEUKIN-17A GENE EXPRESSION IN THE INTESTINAL MUCOSA IN DOGS WITH LYMPHOCYTIC-PLASMACYTIC ENTERITIS AND INFLAMMATORY COLORECTAL POLYP
H. Ohta; K. Takada; Y. Tamura; K. Nakamura; M. Yamasaki; M. Takiguchi, JOURNAL OF VETERINARY INTERNAL MEDICINE, 26, 3, 772, 773, May 2012
English, Summary international conference - ジミナゼン耐性株および野生株におけるBabesia gibsoniミトコンドリアDNAの塩基配列の比較
ウイクラマセカラ B.K.; ラジャパク・シャゲ; 山崎 真大; 中村 健介; 佐々木 東; 村上 正紘; 田村 悠; リン S.Y.; 大田 寛; 滝口 満喜, 獣医寄生虫学会誌, 10, 1-2, 34, 34, Mar. 2012
日本獣医寄生虫学会, Japanese - Babesia gibsoniにおけるdiminazene aceturate抵抗性の安定性(Stability of characteristic of the diminazene aceturate resistance in Babesia gibsoni)
Rajapakshage Bandula Kumara Wickramasekara; 山崎 真大; Hwang Shiang-Jyi; 中村 健介; 佐々木 東; 村上 正紘; 田村 悠; Lim Sue Yee; 大田 寛; 滝口 満喜, 日本獣医学会学術集会講演要旨集, 153回, 221, 221, Mar. 2012
(公社)日本獣医学会, English - 麻酔後の全脳虚血が疑われた猫2例のMRI所見
大田 寛; 山崎 真大; 滝口 満喜, 日本獣医画像診断学会抄録, 50回, 94, 94, Jan. 2012
日本獣医画像診断学会, Japanese - 心エコー図検査にて心内膜心筋線維症と診断した猫4例
NAKAMURA KENSUKE; YAMASAKI MASAHIRO; OTA HIROSHI; MURAKAMI MASAHIRO; MATSUYAMA ARATA; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 42, Suppl.2, 233, 233, Dec. 2011
(一社)日本獣医麻酔外科学会, Japanese - 活性型ビタミンD3外用薬(マキサカルシトール軟膏)常用患者の飼育犬に認められた高カルシウム血症
TOOYAMA NOBUO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 32nd, 2, 149, 150, 18 Nov. 2011
Japanese - 小型犬における下垂体性副腎皮質機能亢進症の超音波診断基準
MATSUYAMA ARATA; TOOYAMA NOBUO; MURAKAMI MASAHIRO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 32nd, 3, 14, 18, 18 Nov. 2011
Japanese - 犬の肝臓腫瘤診断におけるソナゾイド造影超音波検査―4年間の検討―
NAKAMURA KENSUKE; YAMASAKI MASAHIRO; OTA HIROSHI; HOSOYA KENJI; TAKAGI SATOSHI; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 32nd, 3, 6, 9, 18 Nov. 2011
Japanese - ポリエン系抗生物質アムホテリシンBのイヌバベシア症治療薬としての応用に関する研究
YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 32nd, 3, 91, 94, 18 Nov. 2011
Japanese - 超音波診断装置および超音波造影剤による抗がん剤のソノポレーションの抗腫瘍効果
SASAKI NOBORU; NAKAMURA KENSUKE; MURAKAMI MASAHIRO; BANDULA KUMARA WR; LIM SUE YEE; TAMURA YU; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 152nd, 302, 31 Aug. 2011
Japanese - 犬の慢性腸炎症例の腸粘膜におけるIL‐17A遺伝子の発現解析
TAKADA KANAE; OTA HIROSHI; NAKAMURA KENSUKE; SASAKI NOBORU; MURAKAMI MASAHIRO; KUMARA W.R. BANDULA; TAMURA YU; LIM SUE YEE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 152nd, 298, 31 Aug. 2011
Japanese - プロテオーム解析を用いた犬リポ蛋白質測定法の評価
SUDO ASUKA; YAMASAKI MASAHIRO; NAKAMURA KENSUKE; SASAKI NOBORU; MURAKAMI MASAHIRO; KUMARA W.R. BANDULA; TAMURA YU; LIM SUE YEE; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 152nd, 291, 31 Aug. 2011
Japanese - 犬の慢性腸炎症例の結腸粘膜における細胞接着分子クローディンの発現変動
OTA HIROSHI; TAMURA YU; LIM SUE YEE; KUMARA WR BANDULA; MURAKAMI MASAHIRO; SASAKI NOBORU; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 152nd, 298, 31 Aug. 2011
Japanese - 犬の僧房弁閉鎖不全症におけるLeft atrial tracking法を用いた左心房機能評価の有用性
OSUGA TATSUYUKI; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 55, 8, 386, 10 Aug. 2011
Japanese - 後鼻孔領域に炎症性ポリープを認めた若齢犬の1例
WATANABE TAKESHI; OTA HIROSHI; SONO FUMIO; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 55, 8, 387, 10 Aug. 2011
Japanese - 胃癌の犬5例における超音波検査および内視鏡検査所見の特徴
TOOYAMA NOBUO; OTA HIROSHI; TAKAGI SATOSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 55, 8, 397, 10 Aug. 2011
Japanese - 心エコー図検査とD‐dimer測定により診断し得た肺血栓塞栓症の犬の1例
OGI NAOKO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 55, 8, 385, 10 Aug. 2011
Japanese - ジミナゼンアセチュレート耐性Babesia gibsoni株と野生型におけるミトコンドリアDNA配列の比較(Comparison of the sequence of mitochondrial DNA from diminazene aceturate resistance Babesia gibsoni strain with those from wild type)
Rajapakshage Bandula Kumara Wickramasekara; 山崎 真大; 中村 健介; 佐々木 東; 村上 正紘; 田村 悠; Lim Sue Yee; 大田 寛; 滝口 満喜, 日本獣医学会学術集会講演要旨集, 152回, 203, 203, Aug. 2011
(公社)日本獣医学会, English - 仮想気管支鏡検査が診断に有用であった肺葉捻転の犬の2例
MURAKAMI MASAHIRO; NAKAMURA KENSUKE; SASAKI NOBORU; MATSUYAMA SHIN; TAMURA YU; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 42, Suppl.1, 264, 264, Jun. 2011
(一社)日本獣医麻酔外科学会, Japanese - 犬の肝カルチノイド4症例におけるソナゾイド造影超音波検査所見
NAKAMURA KENSUKE; HOSOYA KENJI; YAMASAKI MASAHIRO; OTA HIROSHI; YEE LIM SUE; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 42, Suppl.1, 261, 261, Jun. 2011
(一社)日本獣医麻酔外科学会, Japanese - 犬の心疾患におけるLeft atrial tracking法を用いた左心房機能評価の有用性
OSUGA TATSUYUKI; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 42, Supplement 1, 243, 01 Jun. 2011
Japanese - パルス超音波と微小気泡によるシスプラチンの抗腫瘍効果増強の基礎的知見
SASAKI NOBORU; NAKAMURA KENSUKE; MURAKAMI MASAHIRO; OTA HIROSHI; YAMASAKI MASAHIRO; KUDO NOBUKI; TAKIGUCHI MITSUYOSHI, 超音波医学, 38, 3, 338, 15 May 2011
Japanese - 診断用超音波とマイクロバブルによるドラッグデリバリーのin vitroでの最適化
SASAKI NOBORU; NAKAMURA KENSUKE; MURAKAMI MASAHIRO; KUMARA BADULA; OTA HIROSHI; YAMASAKI MASAHIRO; KUDO NOBUKI; TAKIGUCHI MITSUYOSHI, 超音波医学, 38, S316, 15 Apr. 2011
Japanese - シトシンアラビノシドにより良好に維持されている特発性脳炎の犬の2例
OTA HIROSHI; SASAKI NOBORU; MURAKAMI MASAHIRO; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医皮膚科学会学術大会・総会, 14th, Vol.1, 117, 11 Mar. 2011
Japanese - アムホテリシンBによるイヌバベシア症の治療に関する研究
YAMASAKI MASAHIRO; O KOJAKU; BANDULA KUMARA W. R; TANIYAMA YUSUKE; TSUBOI YOSHIHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 151st, 216, 01 Mar. 2011
Japanese - 第二世代超音波造影剤ソナゾイドを用いた造影超音波検査による犬の肝臓および脾臓腫瘤の診断に関する研究
NAKAMURA KENSUKE; TAKAGI SATOSHI; YAMASAKI MASAHIRO; OTA HIROSHI; SASAKI NOBORU; MURAKAMI MASAHIRO; TAMURA YU; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 151st, 82, 01 Mar. 2011
Japanese - 日本の飼猫におけるTritrichomonas suisの同定と感染状況調査
土井 純子; 廣田 淳一; 森田 明彦; 大田 寛; 山崎 真大; 高橋 徹; 福島 奏絵; 上條 弘美; 片倉 賢; 奥 祐三郎, 獣医寄生虫学会誌, 9, 2, 164, 164, Mar. 2011
日本獣医寄生虫学会, Japanese - アムホテリシンBのin vivoにおける抗バベシア効果に関する研究
YAMASAKI MASAHIRO; HWANG SHIANG-JYI; KUMARA W.R.BANDULA; TANIYAMA YUSUKE; TSUBOI YOSHIHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本寄生虫学会大会プログラム・抄録集, 80th, 73, Feb. 2011
Japanese - シトシンアラビノシドが奏効した肉芽腫性髄膜脳脊髄炎疑いの犬の1例
OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 55, 1, 9, 11, 10 Jan. 2011
Japanese - 微小気泡存在下での診断用超音波照射によるシスプラチンの抗腫瘍効果増強の検討
SASAKI AZUMA; NAKAMURA KENSUKE; MURAKAMI MASAHIRO; BANDULA KUMARA; TAMURA YU; OTA HIROSHI; YAMASAKI MASAHIRO; KUDO NOBUKI; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 150th, 297, 01 Sep. 2010
Japanese - 日本の飼猫におけるTritrichomonas suisの同定と感染状況調査
土井純子; 廣田淳一; 森田明彦; 大田寛; 山崎真大; 高橋徹; 福島奏絵; 上條弘美; 片倉賢; 奥祐三郎, 日本獣医学会学術集会講演要旨集, 150th, 191, 191, 01 Sep. 2010
(公社)日本獣医学会, Japanese - 造影超音波検査により病変の特定が可能であったインスリノーマの犬2例
NAKAMURA KENSUKE; TAKAGI SATOSHI; YAMASAKI MASAHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 54, 8, 460, 10 Aug. 2010
Japanese - 胆嚢粘液嚢腫の犬19症例の回顧的解析
MURATA NAOMITSU; TAKAGI SATOSHI; HOSOYA KENJI; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI; SATO KOTA; OKUMURA MASAHIRO, 北海道獣医師会雑誌, 54, 8, 462, 10 Aug. 2010
Japanese - 細菌性心内膜炎の犬の1例
MORI SHINSUKE; OTA HIROSHI; SAKAI HIDEFUMI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 54, 8, 459, 10 Aug. 2010
Japanese - 犬の皮膚無菌性肉芽腫/化膿性肉芽腫症候群と診断した1症例
WAKAKI NOZOMI; YAMASAKI MASAHIRO; OTA HIROSHI; NASUNO TOYOHIKO; OCHIAI KENJI; TAKEBAYASHI KENSAKU; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 54, 8, 464, 10 Aug. 2010
Japanese - リンパ管拡張症を疑う胸水貯留に続発して肺葉捻転を起こした犬の1例
MURAKAMI MASAHIRO; NAKAMURA KENSUKE; SASAKI AZUMA; OTA HIROSHI; YAMASAKI MASAHIRO; TAKAGI SATOSHI; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 54, 8, 464, 10 Aug. 2010
Japanese - 造影3DCTにより確定診断し得た犬の重複大動脈弓の1例
MATSUYAMA SHIN; KANEKO KAZUNARI; YAMANE YOSHIHISA; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 54, 8, 458, 10 Aug. 2010
Japanese - 心房中隔欠損症と僧帽弁閉鎖不全症を併発した犬の1例
OGI NAOKO; NAKAMURA KENSUKE; MATSUYAMA SHIN; HASHIBA MINORU; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 54, 8, 458, 10 Aug. 2010
Japanese - 経皮的エコーガイド下胆嚢穿刺により確定診断した細菌性胆嚢炎の犬と猫の2例
UKAI AYAKO; KANEKO KAZUNARI; OKAWA MINAKO; OTA HIROSHI; KOBAYASHI HIDEAKI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 54, 8, 461, 10 Aug. 2010
Japanese - 二次性赤血球増加症を伴ったEisenmenger症候群の犬に対するシルデナフィルの有効性の検討
NAKAMURA KENSUKE; YAMASAKI MASAHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 41, Suppl.1, 294, 294, Jul. 2010
(一社)日本獣医麻酔外科学会, Japanese - CONTRAST-ENHANCED ULTRASONOGRAPHY WITH SONAZOID (R) FOR CHARACTERIZATION OF FOCAL SPLENIC LESIONS
K. Nakamura; H. Ohta; M. Yamasaki; M. Takiguchi, JOURNAL OF VETERINARY INTERNAL MEDICINE, 24, 3, 733, 734, May 2010
English, Summary international conference - 培養Babesia gibsoniの末梢血単核球への侵入と増殖の検討
TANIYAMA YUSUKE; YAMASAKI MASAHIRO; HWANG SHIANG-JYI; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本寄生虫学会大会プログラム・抄録集, 79th, 70, May 2010
Japanese - 超音波診断装置と微小気泡によるシスプラチンの抗腫瘍効果の増強
SASAKI NOBORU; NAKAMURA KENSUKE; MURAKAMI MASAHIRO; KUMARA BANDULA; OTA HIROSHI; YAMASAKI MASAHIRO; KUDO NOBUKI; TAKIGUCHI MITSUYOSHI, 超音波医学, 37, S322, 15 Apr. 2010
Japanese - Diminazene aceturate耐性Babesia gibsoni株に対する他の抗バベシア原虫薬の効果
黄 香寂; 谷山 裕介; 山崎 真大; 大田 寛; 滝口 満喜, 獣医寄生虫学会誌, 8, 2, 149, 149, Mar. 2010
日本獣医寄生虫学会, Japanese - 犬の肝臓腫瘤30例に対するソナゾイド造影超音波検査
NAKAMURA KENSUKE; TAKAGI SATOSHI; YAMASAKI MASAHIRO; OTA HIROSHI; SASAKI NOBORU; TAKIGUCHI MITSUYOSHI, 日本獣医師会三学会年次大会講演要旨集, 2009, 237, 07 Jan. 2010
Japanese - 外科手術を実施した犬の肝細胞癌17症例の検討
TAKAGI SATOSHI; TAKIGUCHI MITSUYOSHI; YAMASAKI MASAHIRO; OTA HIROSHI; NAKAMURA KENSUKE; OSAKI TOMOHIRO; HOSOYA YOSHITSUGU; OKUMURA MASAHIRO, 獣医麻酔外科学雑誌, 40, Suppl.2, 196, 196, Dec. 2009
(一社)日本獣医麻酔外科学会, Japanese - 犬のリンパ球プラズマ細胞性腸炎における細胞接着分子クローディンの発現変動
OTA HIROSHI; MURAKAMI MASAHIRO; KUMARA BANDURA; SASAKI NOBORU; NAKAMURA KENSUKE; KO KOJAKU; YAMAZAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 148回, 261, 261, Sep. 2009
(公社)日本獣医学会, Japanese - 犬の肝臓腫瘤28結節に対するソナゾイド造影超音波検査
NAKAMURA KENSUKE; TAKAGI SATOSHI; SASAKI AKIRA; MURAKAMI MASAHIRO; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 53, 8, 479, 01 Aug. 2009
Japanese - 大脳辺縁系の壊死が疑われた猫の1症例
KAMIJO HIROMI; OTA HIROSHI; MATSUMOTO MASANORI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 53, 8, 481, 01 Aug. 2009
Japanese - 筋炎の併発が疑われた劇症型重症筋無力症の犬の1例
UKAI AYAKO; YOSHIKAWA MUNEYOSHI; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; NAKAO KIICHI; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 53, 8, 476, 01 Aug. 2009
Japanese - 本態性高Na血症が疑われた神経症状を示した犬と猫の2例
MURAKAMI MASAHIRO; OTA HIROSHI; NAKAMURA KENSUKE; SASAKI AKIRA; YAMASAKI MASAHIRO; ETO MASAYUKI; KOSEKI YUMI; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 53, 8, 475, 01 Aug. 2009
Japanese - 気管支内視鏡検査で気管支狭窄を認めた慢性発咳の犬の1症例
SASAKI AKIRA; OTA HIROSHI; ANDO REMI; NAKAMURA KENSUKE; MURAKAMI MASAHIRO; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 53, 8, 466, 01 Aug. 2009
Japanese - ボストンテリアの脾臓捻転の1症例
OTA HIROSHI; TAKAGI SATOSHI; NAKAZAWA SHIGEKI; MURAKAMI MASAHIRO; SASAKI AKIRA; NAKAMURA KENSUKE; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 53, 8, 467, 01 Aug. 2009
Japanese - 培養Babesia gibsoniのストレス環境下におけるheat shock protein 70の役割に関する研究
YAMASAKI MASAHIRO; HWANG SHIANG-JYI; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本寄生虫学会大会プログラム・抄録集, 78th, 86, Feb. 2009
Japanese - 小腸の再発性肉芽腫に対して十二指腸空腸吻合術を行ったミニチュアダックスフントの1症例
大崎智弘; 小川修治; 山崎真大; 寸田裕嗣; 梅村孝司; 高木哲; 奥村正裕, 北海道獣医師会雑誌, 53, 8, 2009 - Diminazene aceturate耐性Babesia gibsoni株に対する他の抗バベシア原虫薬の効果
KO KOJAKU; TANIYAMA YUSUKE; YAMASAKI MASAHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 148th, 188, 2009
Japanese - 犬の脾臓腫瘤におけるソナゾイド造影超音波検査の有用性
NAKAMURA KENSUKE; YAMASAKI MASAHIRO; OTA HIROSHI; SASAKI NOBORU; MURAKAMI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 148th, 268, 2009
Japanese - SLEが疑われた血球貪食症候群の猫の1例
YOSHIKAWA MUNEYOSHI; NAKAMURA KENSUKE; SASAKI AZUMA; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医師会三学会年次大会講演要旨集, 2008, 296, 25 Dec. 2008
Japanese - ポリエン系抗生物質アムホテリシンBの抗Babesia gibsoni効果
原田 絵梨子; 山崎 真大; 黄 寂香; 大田 寛; 滝口 満喜, 獣医寄生虫学会誌, 7, 2, 90, 90, Dec. 2008
日本獣医寄生虫学会, Japanese - Diminazene aceturate耐性Babesia gibsoni株の作成
黄 香寂; 山崎 真大; 大田 寛; 滝口 満喜, 獣医寄生虫学会誌, 7, 2, 92, 92, Dec. 2008
日本獣医寄生虫学会, Japanese - 簡便な犬リポ蛋白質の測定法の開発と臨床例への応用
TAKASAKI YUKARI; YAMASAKI MASAHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 29th, 3, 37, 40, 14 Nov. 2008
Japanese - 超音波検査により求めた正常なビーグル犬の甲状腺体積と体重の相関
SASAKI NOBORU; NAKAMURA KENSUKE; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 動物臨床医学会年次大会プロシーディング, 29th, 3, 29, 32, 14 Nov. 2008
Japanese - 犬の肝臓における造影超音波検査の有用性の検討
NAKAMURA KENSUKE; SASAKI HIGASHI; YOSHIKAWA MUNEYOSHI; O KOJAKU; OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 146th, 265, 05 Sep. 2008
Japanese - 犬の消化菅粘膜におけるクローディン分子群の発現:十二指腸を中心として
YAMAGUCHI TOMOO; OTA HIROSHI; NAKAMURA KENSUKE; O KOJAKU; SASAKI HIGASHI; YOSHIKAWA MUNEYOSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 146th, 258, 05 Sep. 2008
Japanese - Diminazene aceturate耐性Babesia gibsoni株の作成
O KOJAKU; YAMASAKI MASAHIRO; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 146th, 173, 05 Sep. 2008
Japanese - ポリエン系抗生物質アムホテリシンBの抗Babesia gibsoni効果
HARADA ERIKO; YAMASAKI MASAHIRO; O KOJAKU; OTA HIROSHI; TAKIGUCHI MITSUYOSHI, 日本獣医学会学術集会講演要旨集, 146th, 172, 05 Sep. 2008
Japanese - 抗リン脂質抗体症候群が疑われた不明熱のミニチュア・ダックスフンドの1例
NAKAMURA KENSUKE; SASAKI NOBORU; YOSHIKAWA MUNEYOSHI; OTA HIROSHI; YAMAZAKI MASAHIRO; OBA MASAYO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 52, 8, 410, 01 Aug. 2008
Japanese - 犬の無菌性好酸球性膿疱症と診断した2症例
MINAMIYAMA ERI; YAMAZAKI MASAHIRO; OTA HIROSHI; HONDA HIDETAKA; NASUNO TOYOHIKO; OCHIAI KENJI; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 52, 8, 413, 01 Aug. 2008
Japanese - 気胸を併発した先天性肺葉性肺気腫の犬の1例
KAMIJO HIROMI; TAKAGI SATOSHI; OTA HIROSHI; YAMAZAKI MASAHIRO; KIMURA TAKASHI; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 52, 8, 420, 01 Aug. 2008
Japanese - エリスロポエチン依存性の二次性多血症が疑われた腎リンパ腫の犬の1例
SASAKI AZUMA; YOSHIKAWA MUNEYOSHI; NAKAMURA KENSUKE; OTA HIROSHI; YAMAZAKI MASAHIRO; SATO KOTA; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 52, 8, 415, 01 Aug. 2008
Japanese - SLEが疑われた血球貪食症候群の猫の1例
YOSHIKAWA MUNEYOSHI; SHODA MASATO; NAKAMURA KENSUKE; SASAKI NOBORU; OTA HIROSHI; YAMAZAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 52, 8, 410, 01 Aug. 2008
Japanese - 犬の炎症性腸疾患:リンパ球形質細胞性腸炎・結腸炎を中心に
OTA HIROSHI; YAMASAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 北海道獣医師会雑誌, 52, 7, 263, 265, 01 Jul. 2008
Japanese - 第二世代超音波造影剤ソナゾイドによる肝臓腫瘤の診断
NAKAMURA KENSUKE; OTA HIROSHI; YAMAZAKI MASAHIRO; TAKIGUCHI MITSUYOSHI, 獣医麻酔外科学雑誌, 39, Supplement 1, 227, 20 Jun. 2008
Japanese - Chemical deicer poisoning was suspected as a cause of the 2005-2006 wintertime mortality of small wild birds in Hokkaido
Tomohisa Tanaka; Ginpei Tanoue; Masahiro Yamasaki; Ikuo Takashima; Yoshihiro Sakoda; Kenji Ochiai; Takashi Umemura, JOURNAL OF VETERINARY MEDICAL SCIENCE, 70, 6, 607, 610, Jun. 2008
English - 薬用植物由来天然化合物bruceine Aのイヌ・バベシア症に対する治療効果
中尾 亮; 水上 智秋; 川村 悠太; スベキ; S.・ボン; 山崎 真大; 前出 吉光; 松浦 英幸; 高橋 公咲; 鍋田 憲助; 野中 成晃; 奥 祐三郎; 片倉 賢, 獣医寄生虫学会誌, 6, 2, 92, 92, Mar. 2008
日本獣医寄生虫学会, Japanese - Anti-babesial quassinoids from the fruits of Brucea javanica
Ahmed Elkhateeb; Masahiro Yamasaki; Yoshimitsu Maede; Ken Katakura; Kensuke Nabeta; Hideyuki Matsuura, NATURAL PRODUCT COMMUNICATIONS, 3, 2, 145, 148, 2008
English - 抗Babesia gibsoni熱ショックタンパク質70抗体のイヌ熱ショックタンパク質70との反応性の検討
YAMAZAKI MASAHIRO; ISHIDA MIKIKO; OTA HIROSHI; MAEDE YOSHIMITSU, 日本獣医学会学術集会講演要旨集, 144th, 61, 27 Aug. 2007
Japanese - 正常犬の血中遊離サイロキシン濃度および血中TSH濃度の生理的変動の評価
SASAKI AZUMA; YAMAZAKI MASAHIRO; OTA HIROSHI; MAEDE YOSHIMITSU, 日本獣医学会学術集会講演要旨集, 144th, 152, 27 Aug. 2007
Japanese - 薬用植物由来天然化合物bruceine Aのイヌ・バベシア症に対する治療効果
中尾亮; 水上智秋; 川村悠太; SUBEKI Subeki; BAWM Saw; 山崎真大; 前出吉光; 松浦英幸; 高橋公咲; 鍋田憲助; 片倉賢, 日本獣医学会学術集会講演要旨集, 144th, 61, 27 Aug. 2007
Japanese - Clinical and molecular analysis of GM2 gangliosidosis in two apparent littermate kittens of the Japanese domestic cat
Daisuke Hasegawa; Osamu Yamato; Masanori Kobayashi; Michio Fujita; Shinichiro Nakamura; Kimimasa Takahashi; Hiroyuki Satoh; Toru Shoda; Daisuke Hayashi; Masahiro Yamasaki; Yoshimitsu Maede; Toshiro Arai; Hiromitsu Orima, JOURNAL OF FELINE MEDICINE AND SURGERY, 9, 3, 232, 237, Jun. 2007
English - 2‐Benzoxazolinone類縁体の抗バベシア活性
山田一明; 野村信吉; 松浦英幸; SU Beki; 山崎真大; 前出吉光; 片倉賢; 吉原照彦; 鍋田憲助, 日本農芸化学会大会講演要旨集, 2007, 250, 05 Mar. 2007
Japanese - インドネシア産薬用植物から抽出したbrucein Aのイヌ・バベシア症に対する治療効果
中尾亮; 水上智秋; 川村悠太; SUBEKI Subeki; SAW Bawm; 山崎真大; 前出吉光; 松浦英幸; 高橋公咲; 鍋田憲助; 片倉賢, 日本寄生虫学会大会プログラム・抄録集, 76th, 64, 23 Feb. 2007
Japanese - 犬の甲状腺機能低下症の診断基準としての化学発光免疫測定法(CLIA法)による甲状腺ホルモン値
SASAKI AKIRA; YAMAZAKI MASAHIRO; OTA HIROSHI; TAJIMA TAKASHI; MAEIDE YOSHIMITSU, 北海道獣医師会雑誌, 50, 8, 333, 01 Aug. 2006
Japanese - 犬の皮膚病における血清アレルギー検査の臨床的意義
HARADA ERIKO; YAMAZAKI MASAHIRO; SATO HIROYUKI; OTA HIROSHI; TAJIMA TAKASHI; MAEIDE YOSHIMITSU, 北海道獣医師会雑誌, 50, 8, 332, 01 Aug. 2006
Japanese - Curcuma xanthorrhizaからの抗バベシア化合物の単離
山田一明; 野村信吉; 松浦英幸; SUBEKI; 山崎真大; 大和修; 前出吉光; 片倉賢; TRIMURNINGSIH; CHAIRUL; 吉原照彦; 鍋田憲助, 日本農芸化学会北海道支部・日本土壌肥料学会北海道支部・日本生物工学会北日本支部・日本応用糖質科学会北海道支部・北海道農芸化学協会合同学術講演会講演要旨, 2006, 14, 2006
Japanese - 多発性の皮膚転移が疑われた犬の移行上皮癌の1症例
高木 哲; 松村 淳; 山崎 真大; 大崎 智弘; 星野 有希; 横川 美穂; 田崎 竜也; 奥村 正裕; 藤永 徹, 北海道獣医師会雑誌, 49, 8, 56, 56, Aug. 2005
(公社)北海道獣医師会, Japanese - 動物の感染症Infectious Diseases of Animals＜第二版＞
（株）近代出版, 2005 - Effects of Central Kalimantan Plant Extracts on Intraerythrocytic Babesia gibsoni in Culture(Internal Medicine)
SUBEKI SUBEKI; MATSUURA Hideyuki; YAMASAKI Masahiro; YAMATO Osamu; MAEDE Yoshimitsu; KATAKURA Ken; SUZUKI Mamoru; TRIMURNINGSIH TRIMURNINGSIH; CHAIRUL CHAIRUL; YOSHIHARA Teruhiko, The journal of veterinary medical science, 66, 7, 871, 874, 25 Jul. 2004
The inhibitory effects of 45 plant extracts selected from Central Kalimantan, Indonesia on Babesia gibsoni in vitro and their acute toxicity to mice were evaluated. Of these plant extracts studied, Arcangelisia flava, Curcuma zedoaria, Garcinia benthamiana, Lansium domesticum and Peronema canescens were found to have appreciable antibabesial activity with IC_<50> values from 5.3 to 49.3 μg/ml without acute toxicity in mice at the intraperitoneal dose of 0.7 g/kg of body weight., Japanese Society of Veterinary Science, English - インドネシア産植物における抗Babesia gibson活性物質の探索
野村信吉; SUBEKI; 松浦英幸; 山崎真大; 大和修; 片倉賢; 鈴木守; TRIMURNINGSIH; CHAIRUL, 日本農芸化学会大会講演要旨集, 2004, 283, 05 Mar. 2004
Japanese - インドネシア産薬用植物Curcuma zedoariaにおける抗バベシア・マラリア活性化合物の探索
笠原堅; 野村信吉; SUBEKI; 松浦英幸; 山崎真大; 大和修; 前出吉光; 片倉賢; 鈴木守; 小林寿美子; TRIMURNINGSIH; CHAIRUL; 吉原照彦, 日本農芸化学会北海道支部・日本土壌肥料学会北海道支部・日本生物工学会北日本支部・日本応用糖質科学会北海道支部・北海道農芸化学協会合同学術講演会講演要旨, 2004, 27, 2004
Japanese - 『猫の臨床』<前出吉光監修>
デーリィマン社, 2004 - Histological, immunohistochemical and electron-microscopic features of lien in dog babesiosis ( Babesia gibsoni infectious disease ) acute phase.
OMAE SHOGO; YAMAZAKI MASAHIRO; TAJIMA TAKASHI; YAMATO OSAMU; MAEDE YOSHIMITSU, 日本獣医学会学術集会講演要旨集, 126th, 161, Aug. 1998
Japanese - On reason of proliferation of Babesia gibsoni heightened in reticulocyte.
YAMAZAKI MASAHIRO; TAJIMA TAKASHI; YAMATO OSAMU; MAEDE YOSHIMITSU, 日本獣医学会学術集会講演要旨集, 125th, 111, Mar. 1998
Japanese - Babesia gibsoni growth promoting substance in reticulocyte.
YAMAZAKI MASAHIRO; TAJIMA TAKASHI; YAMATO OSAMU; MAEDE YOSHIMITSU, 日本獣医学会学術集会講演要旨集, 123rd, 252, Mar. 1997
Japanese - Research on explanting culture of Babesia gibsoni. Especially, on protozoa growth stimulation substance.
ASANO TAKAYUKI; YAMAZAKI MASAHIRO; YAMATO OSAMU; TAJIMA TAKASHI; MAEDE YOSHIMITSU, 日本獣医学会学術集会講演要旨集, 121st, 113, Mar. 1996
Japanese
■ Affiliated academic society
■ Research Themes
- 犬バベシア原虫の薬剤耐性獲得機序の解明とそれを基盤とした新規治療法の開発
科学研究費助成事業
01 Apr. 2023 - 31 Mar. 2026
山崎 真大; 岡村 匡史; 井口 愛子
令和5年度には、まず培養維持しているBabesia gibsoniの野生株から、限界希釈方を用いてジミナゼン・アセチュレートおよびアトバコンに対する感受性の高い薬剤感受性株を分離し、維持を行なった。この薬剤感受性株は今後、本研究において遺伝子組み換えを行うことで薬剤耐性株を作成する上でその元となる重要な株である。次に、本研究課題にして申請していたエレクトロポレーションシステム（スーパーエレクトロポーターType Ⅱ、ネッパジーン）を購入し遺伝子組み換えに取り組んだ。過去にB. gibsoniに対してエレクトロポレーションを用いた遺伝子組み換えを実施した論文が存在するため、その論文の著者である帯広畜産大学原虫病研究センターの玄学南先生に遺伝子組み換え用のプラスミドを分与していただいた。まず、こちらのプラスミドを使用して遺伝子組み換えの検証を試みたが、玄先生らの使用した機器におけるエレクトロポレーションの条件が公表されていないため、計画を変更してB. gibsoniに対するエレクトロポレーションの条件設定から始めることにし、現在も条件設定を行なっているところである。また、分与していただいたプラスミドを基に、研究分担者の岡村匡史先生がトレハロース6リン酸合成酵素の遺伝子を組み込んだプラスミドの作成に成功した。トレハロース6リン酸はこれまでの研究によりB. gibsoniのジミナゼン・アセチュレート耐性に関与することが疑われている遺伝子であり、今後このプラスミドを使用して遺伝子組み換えを行うことにより、ジミナゼン・アセチュレート耐性B. gibsoniの作出を試みる予定である。
日本学術振興会, 基盤研究(C), 岩手大学, 23K05550 - Babesia gibsoniの感染により引き起こされる犬バベシア症の病態解明および治療薬開発。
Competitive research funding - Canine Babesiosis
Competitive research funding
