博士（水産科学）, 北海道大学

地域共創

地域振興

水産植物

水産増養殖

Life Science, Aquatic bioproduction science

May 2006, 平成18年度マリンバイオテクノロジー学会賞
福田覚;北出幸広;遠藤博寿;嵯峨直恆

Electroporation-Mediated Gene Delivery in Pyropia yezoensis (Rhodophyta) Without Cell Wall Removal.
Hikari Izumi; Toshiki Uji; Kojiro Matsumoto; Kaz Nagaosa; Satoru Fukuda
Marine biotechnology (New York, N.Y.), 27, 5, 123, 123, 16 Aug. 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, This study aimed to assess the potential of a gene delivery technique in the red macroalga Pyropia yezoensis (Rhodophyta) using electroporation without removing the cell wall. An antibiotic resistance gene was introduced into P. yezoensis tissues containing cells with intact cell walls through electroporation, followed by selection with the corresponding antibiotic. No germlings survived in the non-electroporated control tissue fragments under antibiotic selection. In contrast, some germlings were observed to survive in the electroporated group. Furthermore, the presence of antibiotic resistance genes was confirmed in the genomic DNA of several antibiotic-resistant germlings. Although reporter genes such as β-glucuronidase (GUS) and green fluorescent protein (GFP) were also introduced as supplementary markers, their expression was not detectable under the tested conditions. These findings provide evidence supporting the successful introduction of antibiotic resistance genes into P. yezoensis cells via electroporation. This study offers a preliminary assessment of a gene delivery strategy in P. yezoensis that bypasses cell wall removal, presenting a straightforward method for introducing foreign genes into Pyropia. To the best of our knowledge, this is the first report to demonstrate successful gene transfer via electroporation in a macroalga without cell wall removal. These results provide valuable insights for the development of genetic transformation systems in red macroalgae.

Isolation and characterization of a spore development mutant in Pyropia yezoensis (Rhodophyta) induced via insertional mutagenesis.
Hikari Izumi; Yuji Nakai; Toshiki Uji; Kaz Nagaosa; Satoru Fukuda; Hiroyuki Mizuta; Naotsune Saga
Journal of phycology, 05 May 2025, [Peer-reviewed], [International Magazine]
English, Scientific journal, Mechanistic elucidation of spore development is essential for understanding reproductive strategies and improving seaweed cultivation. In this study, we isolated a mutant with spore development defects in Pyropia yezoensis (Rhodophyta) from among genetic transformants generated via insertional mutagenesis. We characterized the mutant phenotype and identified the genomic region containing the mutation. The mutant produced spores (archeospores, zygotospores, and conchospores) at every relevant stage of the life history. No evident differences were observed in the appearance of the released spores at any stage under light microscopy between the wild-type and mutant strains; however, the mutant exhibited a trend of reduced spore release compared with the wild-type. Additionally, the archeospores released by the mutant remained round after being released from the sporangium, failed to adhere to the substratum, did not germinate, and showed no cell wall development after 4 days of standard culture, in contrast to the wild-type. Similar results were observed for the zygotospores and conchospores. These findings indicate that the main characteristic of this mutant was poor spore release, and the released spores failed to germinate. Whole-genome sequencing revealed the introduction of exogenous DNA into the nuclear genome of the mutant and suggested the presence of duplications, deletion, and inversion in the mutant genome. Notably, a deletion of approximately 13 kb was detected in the mutant genome flanking the insertion, and this region contained a plant homeodomain, suggesting that homeodomain-containing proteins may regulate spore development in P. yezoensis.

Ishimozuku (Sphaerotrichia firma) lipids containing fucoxanthin suppress fatty liver and improve short chain fatty acid production in obese model mice
Masaki Shibata; Satoru Fukuda; Masaru Terasaki; Hayato Maeda
Frontiers in Sustainable Food Systems, Jan. 2024, [Peer-reviewed], [International Magazine]
English, Scientific journal

Comparative Analysis of Nutritional Compounds in Frozen Farmed Scallop and Bottom-Cultured Japanese Scallop in Mutsu Bay
前多隼人; 前多隼人; 最知美友; 福田覚
日本冷凍空調学会論文集, 38, 3, 2021, [Peer-reviewed]

Promotion of Export and Market Evaluation of Salmon Trout from Aomori Prefecture, Japan
福田覚; 鈴木宏介; 泉ひかり; 前田穣; 永長一茂; 中井雄治; 前多隼人; 岡村恒一; 嵯峨直恆
産学連携学, 17, 2, 2021, [Peer-reviewed]

Characterization and expression profiles of small heat shock proteins in the marine red alga Pyropia yezoensis.
Toshiki Uji; Yohei Gondaira; Satoru Fukuda; Hiroyuki Mizuta; Naotsune Saga
Cell stress & chaperones, 24, 1, 223, 233, Jan. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Small heat shock proteins (sHSPs) are found in all three domains of life (Bacteria, Archaea, and Eukarya) and play a critical role in protecting organisms from a range of environmental stresses. However, little is known about their physiological functions in red algae. Therefore, we characterized the sHSPs (PysHSPs) in the red macroalga Pyropia yezoensis, which inhabits the upper intertidal zone where it experiences fluctuating stressful environmental conditions on a daily and seasonal basis, and examined their expression profiles at different developmental stages and under varying environmental conditions. We identified five PysHSPs (PysHSP18.8, 19.1, 19.2, 19.5, and 25.8). Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis showed that expression of the genes PysHSP18.8, PysHSP19.5, and PysHSP25.8 was repressed at all the developmental stages under normal conditions, whereas PysHSP19.1 and PysHSP19.2 were overexpressed in mature gametophytes and sporophytes. Exposure of the gametophytes to high temperature, oxidative stress, or copper significantly increased the mRNA transcript levels of all the five genes, while exogenous application of the ethylene precursor 1-aminocylopropane-1-carboxylic acid (ACC) significantly increased the expression levels of PysHSP19.2, PysHSP19.5, and PysHSP25.8. These findings will help to further our understanding of the role of PysHSP genes and provide clues about how Pyropia species can adapt to the stressful conditions encountered in the upper intertidal zone during their life cycle.

カシスの魅力と健康機能性
前多 隼人; 西山 広亮; 小舘 めい; 福田 覚; 七島 直樹; 堀江 香代; 冨澤 登志子; 藤田 俊文; 北島 麻衣子; 加藤 陽治
New food industry = ニューフードインダストリー : 食品加工および資材の新知識, 60, 9, 11, 18, エヌエフアイ, Sep. 2018, [Peer-reviewed]
Japanese

Anti-Oxidant and Fucoxanthin Contents of Brown Alga Ishimozuku (Sphaerotrichia divaricata) from the West Coast of Aomori, Japan.
Hayato Maeda; Satoru Fukuda; Hikari Izumi; Naotsune Saga
Marine drugs, 16, 8, 30 Jul. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Fucoxanthin is a specific carotenoid in brown seaweeds with remarkable biological properties. Ishimozuku (Sphaerotrichia divaricata), an edible brown alga from northern Japan, has morphology that is almost identical to that of Okinawa-mozuku (Cladosiphon okamuranus) harvested off Okinawa, Japan. However, because of Ishimozuku's lower availability compared to Okinawa-mozuku, the contents of its nutrient compounds remain unclear. The present study analyzed fucoxanthin and anti-oxidant compound contents of Ishimozuku harvested off the northern coast of Japan from 2014 to 2016. First, 80% ethanol extract solutions were prepared from Ishimozuku harvested from several west coast areas of Aomori, Japan. Then, polyphenol content was analyzed using the Folin⁻Ciocalteu method. Then anti-oxidative effects were analyzed by their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and hydrogen peroxide scavenging activity. Furthermore, fucoxanthin contents were measured using high performance liquid chromatography (HPLC) analysis. Fucoxanthin contents of Ishimozuku were 105.6⁻1148.5 μg/g dry weight. Total polyphenol contents of Ishimozuku were of 0.296⁻0.958 mg/g dry weight: higher than Okinawa-mozuku (0.082 ± 0.011 mg/g dry weight). The anti-oxidation effects of Ishimozuku accompanied the polyphenol content. These results suggest that Ishimozuku contains various anti-oxidant components and has high potential to provide the promotion of human health.

Development of a nuclear transformation system with a codon-optimized selection marker and reporter genes in Pyropia yezoensis (Rhodophyta)
Ryo Hirata; Toshiki Uji; Satoru Fukuda; Hiroyuki Mizuta; Asao Fujiyama; Satoshi Tabata; Naotsune Saga
JOURNAL OF APPLIED PHYCOLOGY, 26, 4, 1863, 1868, Aug. 2014, [Peer-reviewed]
English, Scientific journal

A codon-optimized bacterial antibiotic gene used as selection marker for stable nuclear transformation in the marine red alga Pyropia yezoensis.
Toshiki Uji; Ryo Hirata; Satoru Fukuda; Hiroyuki Mizuta; Naotsune Saga
Marine biotechnology (New York, N.Y.), 16, 3, 251, 5, Jun. 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal, Marine macroalgae play an important role in marine coastal ecosystems and are widely used as sea vegetation foodstuffs and for industrial purposes. Therefore, there have been increased demands for useful species and varieties of these macroalgae. However, genetic transformation in macroalgae has not yet been established. We have developed a dominant selection marker for stable nuclear transformation in the red macroalga Pyropia yezoensis. We engineered the coding region of the aminoglycoside phosphotransferase gene aph7″ from Streptomyces hygroscopicus to adapt codon usage of the nuclear genes of P. yezoensis. We designated this codon-optimized aph7″ gene as PyAph7. After bombarding P. yezoensis cells with plasmids containing PyAph7 under the control of their endogenous promoter, 1.9 thalli (or individuals) of hygromycin-resistant strains were isolated from a 10-mm square piece of the bombarded thallus. These transformants were stably maintained throughout the asexual life cycle. Stable expression of PyAph7was verified using Southern blot analysis and genomic PCR and RT-PCR analyses. PyAph7 proved to be a new versatile tool for stable nuclear transformation in P. yezoensis.

Structural features and gene-expression profiles of actin homologs in Porphyra yezoensis (Rhodophyta).
Yukihiro Kitade; Michiko Nakamura; Toshiki Uji; Satoru Fukuda; Hirotoshi Endo; Naotsune Saga
Gene, 423, 1, 79, 84, 15 Oct. 2008, [Peer-reviewed], [International Magazine]
English, Scientific journal, The marine red alga Porphyra yezoensis contains an actin gene family consisting of at least four isoforms (PyACT1, 2, 3 and 4). The amino acid identity between isoforms exceeds 83%, and each contains a putative nuclear export signal (NES). We scanned the sequences for amino acids in regions homologous to the intermonomeric interface of actin filaments. Few residues expected to engage in cross-linking were conserved between the four isoforms. The results of the sequence analyses suggest that PyACT2 probably functions in the nucleus as a monomer (G-actin) or in other unconventional forms. In addition, the distribution and position of the introns were different from those in florideophycean actin genes. The expression level of PyACT3 in matured gametophytes was significantly higher than in those in a vegetative state, although the mRNA was detected at similar levels in both apical and basal parts of thalli. The expression levels of PyACT2 and 4, on the other hand, did not change significantly between the matured and vegetative gametophytes. The PyACT3 may serve as a molecular marker for monitoring thallus maturation in this species.

IDENTIFICATION OF CROSS-FERTILIZED CONCHOCELIS USING CLEAVED AMPLIFIED POLYMORPHIC SEQUENCE MARKERS IN CROSS-EXPERIMENTS OF PORPHYRA YEZOENSIS (BANGIALES, RHODOPHYTA)(1).
Eun-Jeong Park; Satoru Fukuda; Hirotoshi Endo; Yukihiro Kitade; Naotsune Saga
Journal of phycology, 44, 2, 331, 4, Apr. 2008, [Peer-reviewed], [International Magazine]
English, Scientific journal, As a part of the construction of a Porphyra yezoensis Ueda genetic linkage map, we conducted intraspecific cross-experiments and subsequent screening of cross-fertilized conchocelis by cleaved amplified polymorphic sequence (CAPS) analysis. The cross-experiments were carried out between males of the wildtype (KGJ) and females of the recessive green mutant (TU-2) using two methods, controlled and random crosses. A total of 42 and 186 wildtype-colored conchocelis colonies were obtained from the former and latter experiments, respectively. Among those, 49 DNA samples (14% and 23% obtained from the former and latter crosses, respectively) showed biparental CAPS patterns in the two gene regions (EF-1α open reading frame [ORF] region and V-ATPase). This study represents the first report in which the cross-fertilized conchocelis of P. yezoensis has been directly confirmed by molecular marker. The combination of the simple DNA extraction and CAPS analysis may be applicable in genetic studies of other macroalgae that are monoecious and/or grow slowly in laboratory culture.

Factors influencing efficiency of transient gene expression in the red macrophyte Porphyra yezoensis
Satoru Fukuda; Koji Mikami; Toshiki Uji; Eun-Jeong Park; Toshiharu Ohba; Kiyozo Asada; Yukihiro Kitade; Hirotoshi Endo; Ikunoshin Kato; Naotsune Saga
PLANT SCIENCE, 174, 3, 329, 339, Mar. 2008, [Peer-reviewed]
English, Scientific journal

IDENTIFICATION OF GENES PREFERENTIALLY EXPRESSED DURING ASEXUAL SPORULATION IN PORPHYRA YEZOENSIS GAMETOPHYTES (BANGIALES, RHODOPHYTA)(1).
Yukihiro Kitade; Erika Asamizu; Satoru Fukuda; Maiko Nakajima; Shuuji Ootsuka; Hirotoshi Endo; Satoshi Tabata; Naotsune Saga
Journal of phycology, 44, 1, 113, 23, Feb. 2008, [Peer-reviewed], [International Magazine]
English, Scientific journal, Asexual reproduction via archeospores in Porphyra yezoensis Ueda gametophytes is a very valuable character to nori farming; however, there is little information available on the molecular basis of the developmental process. To identify genes involved in the Porphyra asexual sporulation, we compared the gene expression profiles derived from four developmental stages of the life cycle (three from gametophytes; one from sporophytes) using cDNA macroarray, which includes 4,896 nonredundant expressed sequence tag (EST) groups. Candidate genes were screened by two different macroarray data analyses combined with reverse transcription-PCR (RT-PCR) analysis or Northern analysis. RT-PCR analysis revealed that nine genes (one: similarity to 5'-3' exoribonuclease; the other eight: no sequence similarity to known proteins) were expressed with a gametophyte (G)-specific manner, and two genes (named ASPO2608, ASPO1527) were expressed only in gametophytes that formed archeospores. The deduced amino acid sequences for the latter two genes are predicted to contain signal peptides for secretion at their N-termini. Northern analysis revealed that expression levels of Calvin cycle genes in the gametophytic stage that formed archeospores (G-A stage) were higher than those of the gametophyte blade with no archeospores (G-NA stage). In the macroarray analysis based on the rank data of G-preferentially expressed genes, which were detected in the previous P. yezoensis EST analysis, one gene encoding the cyclase associated protein (CAP) exhibited a change upwardly in the G-A stage >1,000 ranks to the G-NA stage. We propose that ASPO2608 and CAP may function in a signaling pathway of asexual sporulation.

Genetic polymorphism within Porphyra yezoensis (Bangiales, Rhodophyta) and related species from Japan and Korea detected by cleaved amplified polymorphic sequence analysis
Eun-Jeong Park; Satoru Fukuda; Hirotoshi Endo; Yukihiro Kitade; Naotsune Saga
EUROPEAN JOURNAL OF PHYCOLOGY, 42, 1, 29, 40, 2007, [Peer-reviewed]
English, Scientific journal

Functional complementation of an arginine auxotrophic yeast mutant by an argininosuccinate synthetase from Porphyra yezoensis (Rhodophyta)
Hirotoshi Endo; Shuuji Ootsuka; Satoru Fukuda; Yukihiro Kitade; Naotsune Saga
JOURNAL OF PHYCOLOGY, 42, 5, 1066, 1071, Oct. 2006, [Peer-reviewed]
English, Scientific journal

Characterization of a cDNA encoding a homolog of actin-related protein 4 from a marine red alga Porphyra yezoensis
Yukihiro Kitade; Michiko Nakamura; Hirotoshi Endo; Satoru Fukuda; Kazuyoshi Kuwano; Naotsune Saga
FISHERIES SCIENCE, 72, 3, 639, 645, Jun. 2006, [Peer-reviewed]
English, Scientific journal

Preparation of Abalone Enzymes Capable of Cell Wall Degradation of a Marine Red Alga Porphyra yezoensis (Bangiales, Rhodophyta)
OOTSUKA Shuuji; FUKUDA Satoru; SHIBATA Daisuke; SAGA Naotsune; OJIMA Takao
Aquaculture Science, 54, 1, 83, 88, Japanese Society for Aquaculture Science, 20 Mar. 2006, [Peer-reviewed]
Japanese, We extracted a xylanase and a mannanase from Ezo abalone Haliotis discus hannai, and examined the enzyme activity and the ability for cell wall degradation of Porphyra yezoensis. Abalone xylanase was partially purified from the crude enzyme prepared from the digestive fluid by column chromatography on a TOYOPEARL CM-650M. Abalone mannanase was successfully purified from the crude enzyme by column chromatographies on TOYOPEARL CM-650M, hydroxyapatite, and TOYOPEARL HW-50E The gametophytic thalli of P.yezoensis could not be degraded by the xylanase alone. The purified mannanase could degrade the thalli into cell masses consisting of 10-20 cells; however, it produced practically no protoplasts from the thalli. When the thalli were incubated both with the xylanase and the purified mannanase, some protoplasts could be produced from the thalli. The two enzymes may be useful for the studies on cell engineering and asexual seedling production of this alga.

A Preliminary Genetic Analysis of Several Industrially Important Traits in Porphyra yezoensis (Bangiales, Rhodophyta)
UEKI Chika; IITSUKA Osamu; FUKUDA Satoru; ENDO Hirotoshi; KITADE Yukihiro; YASUI Hajime; SAGA Naotsune
Aquaculture Science, 53, 3, 231, 237, Japanese Society for Aquaculture Science, 20 Sep. 2005, [Peer-reviewed]
Japanese, Inheritance of several phenotypes of Porphyra yezoensis was investigated by a cross experiment. The following phenotypes, regarded as important characters in layer cultivation, were subjected in the present study: color, twist, corrugation, hardness, amount of monospores, maturing pattern, maturing rate, thallus collapse and thallus form. Among those, color, twist, hardness and maturing pattern were appeared to be stable and reliable genetic traits. Furthermore, linkage of two phenotypes, twist and maturing pattern, was suggested. This is the first report of a genetic analysis focusing on the important characters for industrial quality, except for color inheritance, and it may be helpful for further investigation of improvement of breeds in Porphyra.

海産紅藻スサビノリの配偶体における薬剤感受性に関する研究
福田 覚; 永田 直樹; 大塚 周二
水産育種, 34, 2, 129, 141, 水産育種研究会, Jul. 2005, [Peer-reviewed]
Japanese

Effect of Two Symbiotic Bacteria for Growth of Porphyra yezoensis (Rhodophyta, Bangiales) in Axenic Culture
MORI Shunsuke; YAMAZAKI Ayano; MATSUYAMA SERISAWA Kazuyo; FUKUDA Satoru; MIZUTA Hiroyuki; SAGA Naotsune
Aquaculture Science, 52, 3, 239, 244, Japanese Society for Aquaculture Science, 20 Sep. 2004, [Peer-reviewed]
Japanese, Symbiotic bacteria BPY-W6 and BPY-W8 were added to an axenic culture strain (TU-1) of Porphyra yezoensis, and the length and width of gametophyte of the organism were measured. Axenic cultures of the gametophyte were used as a control. Area and morphological index value (MIV) were calculated on the basis of the length and width measured. After culture for 42 days, the form of the control strain became the callus-like masses, and the strains which added bacteria became monostromatic gametophytes. The strain in which the average length was most lengthened was one added BPY-W8. The strain in which the average width was most lengthened was one added BPY-W6. The strain in which the average area increased most was one added BPY-W6. Throughout the measurement period, MIV for the strain added BPY-W8 was bigger than that of the strain added BP-YW6. It was suggested that BPY-W6 was the bacteriostrain of which the effect for the elongation of the width is big and tended to form the ova-like gametophyte, and BPY-W8 was the bacteriostrain of which the effect for the elongation of the length is big and tended to form the elliptical-like gametophyte from these results.

Isolation and characterization of an elongation factor-1α gene in Porphyra yezoensis (Rhodophyta)
Satoru Fukuda; Yukihiro Kitade; Hiroshi Miyamoto; Sawako Nagashima; Shuichi Takahashi; Toshiharu Ohba; Kiyozo Asada; Ikunoshin Kato; Naotsune Saga
Journal of Applied Phycology, 15, 1, 81, 86, Springer Science and Business Media LLC, 2003, [Peer-reviewed]
Scientific journal

Isolation, characterization and expression of a cDNA encoding an elongation factor-1α from Porphyra yezoensis (Bangiales, Rhodophyta)
Satoru Fukuda; Shuuji Ootsuka; Yukihiro Kitade; Toshiki Watanabe; Naotsune Saga
Phycological Research, 50, 1, 11, 15, Blackwell Publishing, 2002, [Peer-reviewed]
English, Scientific journal

Isolation of a cDNA encoding a homologue of actin fromPorphyra yezoensis(Rhodophyta)
Yukihiro Kitade; Satoru Fukuda; Maiko Nakajima; Toshiki Watanabe; Naotsune Saga
Journal of Applied Phycology, 14, 2, 135, 141, Springer Science and Business Media LLC, 2002, [Peer-reviewed]
Scientific journal

Research note Rapid extraction of high-quality genomic DNA from Porphyra yezoensis (Bangiales, Rhodophyta)
Maiko Nakajima; Yukihiro Kitade; Osamu Iitsuka; Satoru Fukuda; Naotsune Saga
Phycological Research, 48, 1, 15, 17, Wiley, 07 Mar. 2000, [Peer-reviewed]
Scientific journal

A Double Staining Method for Determining Viability of Protoplasts in Enteromorpha intestinalis(Ulvales ,Chlorophyta)
嵯峨 直恆; 塚田 ゆき; 福田 覚
Bulletin of Institute of Oceanic Research and Development,Tokai University., 21, 51, 55, 東海大学海洋研究所, 2000, [Peer-reviewed]
English

Preliminary Study on Early Development of Monospore of Porphyra yezoensis(Bangiales,Rhodophyta)
北出 幸広; 福田 覚; 嵯峨 直恆
Fish genetics and breeding science, 28, 27, 34, 水産育種研究会, Oct. 1999, [Peer-reviewed]
English

ソルト-シリカビーズ法 : 海産紅藻アマノリ属植物からの簡易DNA抽出法
中嶋 舞子; 北出 幸広; 福田 覚
水産育種, 28, 131, 135, 水産育種研究会, Oct. 1999, [Peer-reviewed]
Japanese

A Preliminary Study on Phylogenetic Position of Bangia atropurpurea Strain OM-1(Bangiales,Rhodophyta)Based on the SSU rDNA Sequence
Shimomura, Kengo.; Yamazaki, Satoru.; Fukuda, Satoru.; Miyata, Tatsuo.; Saga, Naotsune
Bulletin of Institute of Oceanic Research and Development,Tokai University., 20, 99, 102, 東海大学海洋研究所, 1999, [Peer-reviewed]
English

Large-scale smolt production in a semi-recirculating aquaculture system for commercial salmon farming in Aomori Prefecture, north Japan
鈴木宏介; 泉ひかり; 福田覚; 福田覚, 水産増殖, 73, 3, 2025

北海道大学地域水産業共創センターが取組むCREEN人材育成プログラムの紹介
福田覚; 三瓶真; 阿部義之; 今村聖祐; 鈴木宏介; 佐藤哲生; 浦和寛; 大木淳之; 向井徹; 藤森康澄; 細川雅史; 綿貫豊; 都木靖彰, 産学連携学会大会講演予稿集(CD-ROM), 22nd, 2024

Studies on the molecular mechanism of spore development in Neopyropia yezoensis, using mutants
泉ひかり; 福田覚; 嵯峨直恆, アグリバイオ, 8, 9, 2024

産学官連携による青森県のサーモン養殖実証事業と大規模養殖技術の活用
福田覚; 泉ひかり; 鈴木宏介, JMOAレポート, 25, 2023

北海道大学地域水産業共創センターと産学官連携事業の紹介
福田覚; 三瓶真; 阿部義之; 今村聖祐; 佐藤哲生; 浦和寛; 大木淳之; 向井徹; 藤森康澄; 細川雅史; 綿貫豊; 都木靖彰, 産学連携学会大会講演予稿集(CD-ROM), 21st, 2023

マーケットイン型養殖業に向けた青森サーモンのマーケティング調査研究の取組み
福田覚; 泉ひかり; 永長一茂; 鈴木宏介, 産学連携学会大会講演予稿集(CD-ROM), 20th, 2022

ミズダコの内臓および表皮に含まれる脂質の分析
鈴木莉那; 角勇悦; 高田偲帆; 福田覚; 松原久; 樋口智之, 脂質栄養学, 31, 2, 2022

青森県産海藻の潜在的ながん予防作用の解析
永長一茂; 永長一茂; 櫛引雅子; 前多隼人; 前多隼人; 泉ひかり; 泉ひかり; 福田覚; 福田覚; 加藤陽治, がん予防学術大会プログラム・抄録集, 2022, 2022

養殖技術講座-トラウト-5000tの大規模生産を目指す青森県の日本サーモンファーム
福田覚; 泉ひかり; 嵯峨直恆; 鈴木宏介, 月刊養殖ビジネス, 59, 2, 2022

ショウジョウバエを用いたカシスの細胞競合促進作用の解析
永長一茂; 櫛引雅子; 山本歩; 泉ひかり; 福田覚, がん予防学術大会プログラム・抄録集, 2021 (CD-ROM), 2021

青森県産トラウトサーモン大規模養殖の産業化に向けた調査研究の取組み
福田覚; 若狹幸; 吉田曉弘; 久保田健; 永長一茂; 前多隼人; 岡村恒一; 鈴木宏介, 産学連携学会大会講演予稿集(CD-ROM), 19th, 2021

イシモズク脂質成分による高脂肪食投与マウスに対する脂質代謝改善作用
柴田真樹; 福田覚; 前多隼人, 日本栄養・食糧学会大会講演要旨集, 75th, 2021

スサビノリの野生株と外来遺伝子導入株の交雑
泉ひかり; 宇治利樹; 水田浩之; 嵯峨直恆; 福田覚, 日本水産学会大会講演要旨集, 2020, 2020

食品由来の細胞競合促進成分の特定
永長一茂; 福田覚; 泉ひかり, がん予防学術大会プログラム・抄録集, 2020, 2020

青森県産サーモン養殖に資する屋外循環式の大規模中間育成魚高密度生産システムの研究開発
福田覚; 鈴木宏介; 泉ひかり; 永長一茂; 嵯峨直恆; 岡村恒一, 産学連携学会大会講演予稿集(CD-ROM), 18th, 2020

Anti-chronic inflammation effects of carotenoids and seasonality change of fucoxanthin contents in algae
前多 隼人; 泉 ひかり; 福田 覚, アグリバイオ = Agricultural biotechnology, 3, 9, 872, 876, Aug. 2019
北隆館, Japanese

Health functionality of carotenoids and research for useful food resources
前多 隼人; 泉 ひかり; 福田 覚, 地域ケアリング, 21, 6, 92, 96, Jun. 2019
北隆館, Japanese

低・未利用海藻(イシモズク)を活用した共同研究・商品開発の事例紹介
福田覚; 泉ひかり; 永長一茂; 嵯峨直恆; 前多隼人, 産学連携学会大会講演予稿集(CD-ROM), 17th, 2019

変異細胞の除去をターゲットとした潜在的ながん予防食品探索
永長一茂; 福田覚; 泉ひかり, がん予防学術大会プログラム・抄録集, 2019

Health functionality of carotenoids and research for useful food resources
前多 隼人; 泉 ひかり; 福田 覚, アグリバイオ = Agricultural biotechnology, 2, 8, 800, 804, Jul. 2018
北隆館, Japanese

Health functionality of carotenoids and research for useful food resources
前多 隼人; 泉 ひかり; 福田 覚, アグリバイオ = Agricultural biotechnology, 2, 6, 580, 584, Jun. 2018
北隆館, Japanese

青森市産完熟トマトを利用した加工品開発の事例紹介
福田覚; 泉慎也; 泉慎也; 泉ひかり; 嵯峨直恆; 前多隼人, 産学連携学会大会講演予稿集(CD-ROM), 16th, 2018

白神の水を活用した青森県産サーモン中間育成システムの研究開発
福田覚; 泉ひかり; 小坂善信; 前田穣; 鈴木宏介; 岡村恒一; 嵯峨直恆, 産学連携学会大会講演予稿集(CD-ROM), 16th, 2018

陸奥湾産ホタテガイの付加価値化に資する評価調査の試み
福田覚; 室館麻衣子; 泉慎也; 泉ひかり; 嵯峨直恆, 産学連携学会大会講演予稿集(CD-ROM), 15th, 2017

イシモズクがショウジョウバエ遺伝子発現に与える影響:DNAマイクロアレイ解析
中井雄治; 福田覚; 永長一茂, 日本農芸化学会大会講演要旨集(Web), 2017, 2017

産学官金連携によるサーモン養殖実証事業の取組み
嵯峨直恆; 福田覚; 泉ひかり; 泉慎也; 室館麻衣子; 前田穣; 鈴木宏介; 岡村恒一, 産学連携学会大会講演予稿集(CD-ROM), 15th, 2017

青森県産サーモントラウトの輸出に関する予備的知見の報告
福田覚; 泉ひかり; 泉慎也; 室館麻衣子; 岡村恒一; 嵯峨直恆, 産学連携学会大会講演予稿集(CD-ROM), 15th, 2017

青森市産食の総合プロデュースに関する取組み
福田覚; 泉慎也; 室館麻衣子; 泉ひかり; 嵯峨直恆, 産学連携学会大会講演予稿集(CD-ROM), 15th, 2017

食のブランドで地域振興 サーモン養殖で市場を拓く
福田覚, 産学官連携ジャーナル(Web), 13, 6, 2017

ホタテ加工残渣(ホタテウロ)の畜産用飼料化技術開発の取組み
福田覚; 関秀司; 川辺雅生, 産学連携学会大会講演予稿集(CD-ROM), 14th, 2016

青森県産農林水産物の高機能ブランド化(高付加価値化)に向けた取組
福田覚; 嵯峨直恆, 産学連携学会大会講演予稿集, 13th, 2015

紅藻スサビノリにおける改変ハイグロマイシン耐性遺伝子を選択マーカーとした形質転換技術の開発
宇治利樹; 平田遼; 福田覚; 水田浩之; 嵯峨直恆, 日本水産学会大会講演要旨集, 2014, 2014

函館市国際水産・海洋総合研究センターと産学官連携事業の紹介
仲川昇一; 伊藤晶; 福田覚; 福田覚, 産学連携学会大会講演予稿集, 12th, 2014

産学官連携による水産加工残渣(イカゴロ)の飼料化技術の研究開発
福田覚; 関秀司; 川辺雅生, 産学連携学会大会講演予稿集, 11th, 2013

国際水産・海洋総合研究センター開設に向けた函館市の産学官連携の取組
福田覚, 産学連携学会大会講演予稿集, 10th, 2012

函館市における国際水産・海洋総合研究センター開設に向けて~函館国際水産・海洋都市構想の実現~
福田覚, 産学連携学会大会講演予稿集, 9th, 2011

函館国際水産・海洋都市推進機構における産学官連携の取組
福田覚, 産学連携学会大会講演予稿集, 8th, 2010

紅藻スサビノリにおける一過的遺伝子発現系の開発
宇治利樹; 三上浩司; 福田覚; 大場利治; 浅田起代蔵; 北出幸広; 遠藤博寿; 朴恩貞; 加藤郁之進; 嵯峨直恆, 日本植物生理学会年会要旨集, 49th, 2008

海洋モデル植物スサビノリの大量培養技術の開発
福田覚; 福田覚; 北出幸広; 遠藤博寿; 嵯峨直恆, マリンバイオテクノロジー学会大会講演要旨集, 10th, 2007

紅藻スサビノリ配偶体の成熟をモニターする分子マーカーの探索
北出幸広; 中村理湖; 宇治利樹; 福田覚; 遠藤博寿; 嵯峨直恆, 生化学, 2007

海産紅藻スサビノリのアクチン関連タンパク質4ホモログをコードするcDNAの解析
北出幸広; 中村理湖; 遠藤博寿; 福田覚; 桑野和可; 嵯峨直恒, 日本水産学会大会講演要旨集, 2006, 2006

海産紅藻スサビノリのARG1遺伝子を用いた酵母栄養要求性突然変異体のレスキュー実験
遠藤博寿; 大塚周二; 福田覚; 北出幸広; 嵯峨直恒, マリンバイオテクノロジー学会大会講演要旨集, 8th, 2005

海産紅藻スサビノリの配偶体における薬剤感受性について
永田直樹; 福田覚; 大塚周二; 嵯峨直恒, 日本水産学会大会講演要旨集, 2005, 2005

海藻由来の有用物質生産に向けたモデル海洋植物スサビノリの利用
福田覚; 福田覚; 大塚周二; 遠藤博寿; 北出幸広; 嵯峨直恒; 尾島孝男, 日本分子生物学会年会講演要旨集, 28th, 2005

スサビノリ研究へのマイクロアレイ手法の導入
森島輝; 吉川美和子; 福田覚; 川津美保子; 新妻亜希子; 小林敬典; 岡崎登志夫; 中山一郎, 日本水産学会大会講演要旨集, 2004, 2004

海産紅藻スサビノリの単胞子形成に関する遺伝子の探索
北出幸広; 浅水恵理香; 中嶋舞子; 福田覚; 田畑哲之; 嵯峨直恒, 日本水産学会大会講演要旨集, 2003, 2003

海産紅藻スサビノリのエロンゲーションファクター-1α遺伝子のクローニング
福田覚; 北出幸広; 宮本裕史; 長島佐和子; 高橋秀一; 大場利治; 浅田起代蔵; 加藤郁之進; 嵯峨直恒, 日本水産学会大会講演要旨集, 2003, 2003

海産紅藻スサビノリのアクチン遺伝子のクローニング
北出幸広; 福田覚; 中嶋舞子; 渡辺俊樹; 嵯峨直恒, 日本水産学会大会講演要旨集, 2000, 2000

紅色植物スサビノリにおける発現ベクターの開発に関する予備的研究
福田覚; 中嶋舞子; 北出幸広; 宮本裕史; 嵯峨直恒, 日本植物学会大会研究発表記録, 63rd, 1999

Lineage of primitive red alga Porphyra by 18S rDNA. Pre-report.
福田覚; 山崎悟; 下村謙悟; 宮田達夫; 嵯峨直恒, マリンバイオテクノロジー学会大会講演要旨集, 1st, 1997

SDGsを足許から考えかたちにする
平井太郎; 北原啓司; 小岩直人; 福田 覚; 今田匡彦; 佐々木純一郎; 内山大史; 金目哲郎; 土井良浩; 杉山祐子, 第2章 北日本の水産資源を利活用した地域振興
弘前大学出版会, 14 Mar. 2022, 9784907192983, [Joint work]

生徒のキャリア教育と漁業担い手確保に向けた調査を両立させる研究開発
科学研究費助成事業
01 Apr. 2025 - 31 Mar. 2028
福田 覚; 山下 俊介; 宮下 和士
日本学術振興会, 基盤研究(C), 北海道大学, 25K06214

Research and development of new breeding basic technology by genome editing in the marine red alga Neopyropia yezoensis (Rhodophyta)
Grants-in-Aid for Scientific Research
01 Apr. 2017 - 31 Mar. 2020
Fukuda Satoru
The purpose of this study is to establish the genome editing technology of Neopyropia yezoensis by applying our gene transfer technology. Although this study could not demonstrate genome editing by the microinjection method, it was confirmed that the reporter gene introduced by the method was transiently expressed in Neopyropia yezoensis cells. It was suggested that the microinjection method contributes to gene transfer technology including genome editing of Neopyropia yezoensis.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hirosaki University, 17K07902

Research and development of new breeding base technology to contribute to the breeding of marine plant Pyropia yezoensis
Grants-in-Aid for Scientific Research
29 Aug. 2014 - 31 Mar. 2016
Fukuda Satoru
The purpose of this study, using the transformation techniques of Pyropia yezoensis, was to research and develop new breeding base technology to contribute to the nori breeding. In this study, we tried to produce transformants with a reporter gene. However, transformant candidates to clearly express the reporter gene was not confirmed. As a result, transformant candidates available for demonstration of meiosis P. yezoensis was not obtained. In conclusion, to increase the transformation efficiency, it is suggested that the gene transfer technology of P. yezoensis be still improved.
Japan Society for the Promotion of Science, Grant-in-Aid for Research Activity Start-up, Hirosaki University, 26892003

ホタテ加工残渣(ホタテウロ)の畜産用飼料化技術の研究開発
2014 - 2015
福田 覚
目標達成するため、初めにホタテウロが可溶化（スラリー状）となる適切な条件を探索し、スラリー状にする条件を確立することに成功した。次に競争吸着法により、脱カドミウムしたホタテウロはカドミウム濃度が1.7mg/kgを示し、飼料安全法の3.0mg/kgを下回った。したがって、目標である競争吸着法によるホタテウロのカドミウム分離条件の確立を達成した。脱カドミウムしたホタテウロは液状のため乾燥する必要があり、脱脂米糠に吸着させ乾燥後、大豆粕の代替として利用できるかどうかの検討を行った結果、代替できることが分かった。今後は実際に畜産用飼料として利活用可能か実証への展開が考えられる。
科学技術振興機構, 産学が連携した研究開発成果の展開/研究成果展開事業/研究成果最適展開支援プログラム(A-STEP)/探索タイプ, 14540278